29:
325:(in both children and adults). The old Rexar facility underwent extensive renovations and improvements, and continued to manufacture the drug for several years. During these years, the drug Adderall was identical to the most recent formulation of Obetrol, except that the inscription on the pills was changed to "AD".
292:
Because FDA considered combinations of amphetamine and dextroamphetamine salt a single entity, Rexar simply reformulated
Obetrol to exclude methamphetamine salts and continued to sell this new formulation under the same Obetrol brand name. This new unapproved formulation was later rebranded and sold
273:
In 1970 the FDA issued an order requiring new drug applications for previously approved amphetamine products. The FDA was critical of combinations of amphetamines and non-amphetamines, but also considered amphetamine and methamphetamine mixtures a combination drug, and required the ingredients to be
328:
Sometime after 2000, Shire closed the Rexar manufacturing facility, discontinued immediate-release
Adderall and outsourced Adderall XR (extended-release) to a manufacturer in North Carolina. Other companies had begun manufacturing generic versions of Adderall, and the trade name was eventually sold
269:
Obetrol was also available in 20 mg tablets which contained twice the quantity of its ingredients, in the same proportions. The 10 mg tablets were blue, and the 20 mg were orange. Both were inscribed with the letters, "OP".
297:
by
Richwood after it acquired Rexar resulting in FDA warning in 1994. Richwood resubmitted this formulation as NDA 11-522 and Adderall gained FDA approval for the treatment of attention-deficit/hyperactivity disorder on February 13, 1996.
218:. The company later became a division of Rexar Pharmacal Corporation, which was also headquartered in Brooklyn. Sometime prior to 1972, Rexar Pharmacal moved its manufacturing facilities, including its Obetrol Pharmaceutical Division, to
197:, between 1965 and 1973, Obetrol was marketed in 10 mg and 20 mg strength through Obetrol Pharmaceuticals division of the American pharmaceutical company Rexar. When sold directly to physicians, Obetrol used the brand name
476:
222:. By the 1990s, Obetrol Pharmaceuticals had been wholly absorbed by Rexar Pharmacal and was no longer noted as a division of Rexar. In 1993, Rexar was acquired by Richwood Pharmaceuticals of
278:
program. The FDA cited the research submitted was vague, subjective, lacking controls or poorly controlled, incomplete, did not test individual ingredients, and had other deficiencies.
541:
425:
358:. "Obetrolling" or "doubling" were the terms used by the character to refer to getting wired on Obetrol, which increased his self-awareness and made him feel alive.
147:
488:'Obetrol' was the trade name when the drug was sold to wholesalers, while 'Oby-Rex' was the trade name used when the same drug was sold to doctors.
175:. It was originally sold by the American company Obetrol Pharmaceuticals. Obetrol was a popular diet pill in America in the 1950s and 1960s.
321:
When
Richwood acquired Rexar, the drug's name was changed from Obetrol to Adderall, and the drug was marketed for use in the treatment of
397:
549:
322:
649:
332:
There is no drug commercially marketed called
Obetrol at this time, nor has there been since Richwood acquired Rexar Pharmacal.
659:
622:
418:
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274:
effective and safe individually and in combination. In
September 1973 the FDA withdrew approval for Obetrol under the FDA
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154:
424:. Center for Drug Evaluation and Research (CDER) – United States Food and Drug Administration (FDA). 2006-02-01.
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These tablets were also blue and orange, and were inscribed with the numbers "32" and "33" respectively.
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The ready availability of methamphetamine-based medications in the 1960s led to their use and abuse as
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419:"Adverse events reported with immediate-release mixed amphetamine salt products"
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475:. Vol. 28. U.S. Government Printing Office. 1975. p. 13586.
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In the 1950s, Obetrol was manufactured by
Obetrol Pharmaceuticals, in
301:
The reformulated
Obetrol (and Adderall) contained equal portions of:
294:
190:(FDA) on January 19, 1960, under the name Obetrol. Indicated for
28:
256:
252:
194:
172:
386:. New York: New York University Press. p. 148, fig.33.
344:. Obetrol was the recreational drug of choice for artist
348:. Obetrol was abused by a character named Chris Fogle in
459:(25 ed.). Medical Economics. 1973. p. 1027.
452:(20 ed.). Medical Economics. 1966. p. 811.
329:
226:, which in 1995 merged with Shire Pharmaceuticals.
613:Wallace DF (2011). "Chapter 22 or subsection 22".
636:
608:
606:
167:was the brand name of a drug combining several
235:lists Obetrol containing (10 mg tablet):
384:On speed : the many lives of amphetamine
603:
411:
472:Competitive Problems in the Drug Industry
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171:indicated for the treatment of exogenous
612:
594:
572:"Obetrol Pill Images - Pill Identifier"
637:
542:"REGULATORY NEWS: Richwood's Adderall"
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288:Amphetamine mixed salts (medication)
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548:. 22 February 1996. Archived from
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276:Drug Efficacy Study Implementation
14:
671:
513:
493:
27:
479:from the original on 2022-07-30
431:from the original on 2011-08-19
400:from the original on 2021-03-02
380:"A bromide for the Go-Go Years"
204:
650:Combination anti-obesity drugs
588:
564:
463:
368:
1:
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660:Withdrawn anti-obesity drugs
308:Dextroamphetamine saccharine
245:2.5 mg methamphetamine
239:2.5 mg methamphetamine
188:Food and Drug Administration
178:The original formulation of
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281:
209:
10:
676:
457:Physicians' Desk Reference
450:Physicians' Desk Reference
323:Attention Deficit Disorder
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232:Physicians' Desk Reference
305:Dextroamphetamine sulfate
186:was approved by the U.S.
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655:Substituted amphetamines
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229:The 1972 edition of the
220:Valley Stream, New York
180:amphetamine mixed salts
314:Amphetamine aspartate
350:David Foster Wallace
311:Amphetamine sulfate
23:
595:Bockris V (1990).
342:recreational drugs
224:Florence, Kentucky
216:Brooklyn, New York
19:
624:978-0-241-14480-0
617:. Penguin Adult.
546:Health News Daily
263:dextroamphetamine
169:amphetamine salts
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42:Dextroamphetamine
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148:(what is this?)
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71:Psychostimulant
66:Methamphetamine
59:Psychostimulant
47:Psychostimulant
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36:Combination of
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615:The Pale King
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579:. Retrieved
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554:. Retrieved
550:the original
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402:. Retrieved
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261:2.5 mg
255:amphetamine
251:2.5 mg
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205:Formulations
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164:
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100:Legal status
94:Legal status
376:Rasmussen N
346:Andy Warhol
124:Identifiers
115:Schedule II
54:Amphetamine
639:Categories
599:. Penguin.
581:2024-06-23
483:2022-07-05
435:2013-05-20
404:2016-11-06
362:References
241:saccharate
130:ChemSpider
576:Drugs.com
352:'s novel
192:exogenous
83:Routes of
16:Diet pill
645:Adderall
477:Archived
426:Archived
398:Archived
378:(2008).
295:Adderall
282:Modified
210:Original
155:(verify)
265:sulfate
257:sulfate
253:racemic
199:Oby-Rex
195:obesity
173:obesity
165:Obetrol
21:Obetrol
621:
597:Warhol
556:29 May
390:
113:
509:26748
429:(PDF)
422:(PDF)
336:Abuse
619:ISBN
558:2013
527:4279
388:ISBN
182:and
137:none
89:Oral
522:38
504:38
293:as
641::
605:^
574:.
544:.
533:^
524:FR
515:^
506:FR
495:^
486:.
454:;
396:.
382:.
201:.
109:US
627:.
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560:.
438:.
407:.
111::
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