1727:, in particular 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency. Overall, CYP17A1 is an important target for inhibition in the treatment of prostate cancer because it produces androgen that is required for tumor cell growth. The decreased enzyme activity of CYP17A1 is related to infertility due to hypogonadotropic hypogonadism. In females, folliculogenesis is arrested, while in males, testicular atrophy with interstitial cell proliferation and arrested spermatogenesis. Although generally anovulatory, there are some case reports of women with 17α-hydroxylase deficiency who underwent spontaneous menarche with cyclic menses.
534:
3325:
and in nonhuman primates VT464 was able to suppress circulating testosterone as effectively as abiraterone, but with minimally depressed cortisol (remaining at 82% control compared to only 9% with aberaterone), and without associated increases in pregnenolone, progesterone and mineralocorticoids otherwise observed with abiraterone. Like
Galaterone, VT464 is also in use in clinical trials without co-administration of prednisone. Together with the clear lack of suppression of circulating cortisol in nonhuman primates, these data argue that VT464 may indeed be a selective 17,20 lyase inhibitor.
511:
1917:
433:
408:
1903:
1875:
785:
540:
439:
1838:
1936:
1889:
1861:
3324:
VT464 is another recently developed compound proposed to act as a selective lyase inhibitor, and more complete data is available in the public domain to support this claim. A review of preliminary data released suggest the IC50 for Human CYP17 lyase activity is ten times lower than for hydroxylase 15
1761:
Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous CYP17A1 substrates. Abiraterone is structurally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and interference can
1741:
A multi-locus genetic risk score study based on a combination of 27 loci, including the CYP17A1 gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a
61:
P450c17, CYP17A1, steroid 17-alpha-hydroxylase/17,20 lyase, CYPXVII, cytochrome P450 17A1, cytochrome p450 XVIIA1, cytochrome P450-C17, cytochrome P450, family 17, subfamily A, polypeptide 1, steroid 17-alpha-monooxygenase, cytochrome P450c17, 4.1.2.30, 17-alpha-hydroxyprogesterone aldolase,
249:
2948:
Kostin VA, Zolottsev VA, Kuzikov AV, Masamrekh RA, Shumyantseva VV, Veselovsky AV, et al. (November 2016). "Oxazolinyl derivatives of -21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity".
2801:
Ma YN, Cao CY, Wang QW, Gui WJ, Zhu GN (October 2016). "Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio)".
1766:
scaffolds is expected to enable the design of compounds that interact more selectively with CYP17A1. Potent inhibitors of the CYP17A1 enzyme provide a last line defense against ectopic androgenesis in advanced prostate cancer.
5857:
1742:
community cohort study (the Malmo Diet and Cancer study) and four additional randomized controlled trials of primary prevention cohorts (JUPITER and ASCOT) and secondary prevention cohorts (CARE and PROVE IT-TIMI 22).
547:
446:
5553:
3450:"Mutation of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having glucocorticoid-responsive hyperaldosteronism: with a review of Japanese patients with mutations of CYP17"
5726:
1824:
which is aimed to avoid co-administration of glucocortoid therapy. In the 2010s it underwent various phases of clinical studies and preclinical models as a drug against prostate cancer or breast cancer.
5762:
3388:"A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer"
5831:
5794:
5853:
5626:
3644:
3557:
Haider SM, Patel JS, Poojari CS, Neidle S (July 2010). "Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy".
1810:
that is now little used. However, ketoconazole competitively inhibits CYP17A1, therefore its effectiveness will depend on the concentration of ketoconazole. This is in contrast to the
1731:
1724:
1713:
1723:
In humans, the CYP17A1 gene is largely associated with endocrine effects and steroid hormone metabolism. Furthermore, mutations in the CYP17A1 gene are associated with rare forms of
2780:
3154:"Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency"
223:
177:
3637:
4889:
3630:
2442:
Storbeck KH, Swart P, Africander D, Conradie R, Louw R, Swart AC (April 2011). "16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction".
1778:, blocks the biosynthesis of androgens by inhibiting the CYP17A1 enzyme. Abiraterone acetate binds in the active site of the enzyme and coordinates the
1043:
355:
1024:
1688:. Cytochrome b5 acts as a facilitator for 17,20 lyase activity of CYP17A1 and can donate a second electron to some P450s. In humans the production of
5354:
2875:
2202:"Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials"
4798:
2034:
196:
2016:
4938:
3622:
1526:
metabolism, though it orients the steroid ligands toward the F and G helices, perpendicular to the heme group, rather than the β1 sheet.
3604:
1243:
5110:
2629:"Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome"
4014:
4009:
3339:"Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment"
5092:
5088:
4428:
4251:
1954:
1250:
5716:
4777:
4297:
3840:
3270:
189:
1669:. Mutations in this gene are associated with isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency,
5609:
3786:
2776:
1364:
tissues. It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces
5784:
5523:
5361:
5070:
4594:
4204:
3954:
156:
5881:
6247:
6237:
3610:
1700:. Phosphorylation of the protein increases 17,20-lyase activity, while dephosphorylation virtually eliminates this activity.
2096:
1999:
5457:
5014:
4930:
3723:
1797:
1775:
246:
5501:
5684:
5255:
4954:
3781:
3105:"Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer"
1978:
4142:
4098:
4001:
3271:"Tokai Pharmaceuticals' Reformulated Galeterone Demonstrates Robust PSA Reductions in Advanced Prostate Cancer Patients"
4090:
4026:
533:
5958:
5657:
4994:
2129:
4229:
1653:
such as cortisol, but both the hydroxylase and 17,20-lyase activities of CYP17A1 are required for the production of
5333:
2688:"Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development"
2257:
2067:
510:
62:
cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), steroid 17 alpha-hydroxylase/17,20 lyase, IPR033282
3512:
Strauss JF (November 2003). "Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome".
150:
5696:
5642:
5131:
4972:
4851:
4550:
3898:
3728:
2003:
1982:
1717:
1697:
1518:, CYP17A1 possesses the canonical cytochrome P450 fold present in other complex P450 enzymes that participate in
5317:
5124:
3879:
1709:
1674:
1088:
137:
132:
6114:
5028:
4998:
4958:
4946:
4244:
4214:
3802:
432:
407:
3921:
3869:
1069:
5182:
5096:
5084:
3652:
1916:
335:
201:
2839:"Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat"
2838:
546:
445:
125:
5925:
5774:
5234:
4934:
4602:
4209:
3763:
1902:
1874:
2250:"CYP17A1 - Steroid 17-alpha-hydroxylase/17,20 lyase - Homo sapiens (Human) - CYP17A1 gene & protein"
539:
438:
5516:
5117:
5056:
5052:
5040:
5036:
5032:
1494:
protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508
2997:"Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors"
1908:
1880:
1662:
1506:
prosthetic group to catalyze biosynthetic reactions. Based on its known structures while bound to two
1408:
1404:
6215:
6202:
6189:
6176:
6163:
6150:
6137:
6099:
5920:
5871:
5843:
5811:
5420:
5305:
5074:
3874:
2060:"CYP17A1 cytochrome P450 family 17 subfamily A member 1 [Homo sapiens (human)] - Gene - NCBI"
1790:
1681:
857:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
153:
51:
3593:
322:
77:
6242:
6109:
6063:
6006:
5544:
5489:
5227:
5174:
5169:
5024:
4875:
4272:
4237:
3776:
3597:
1643:
1636:
1416:
1397:
379:
343:
34:
3483:
Miller WL, Geller DH, Auchus RJ (1999). "The molecular basis of isolated 17,20 lyase deficiency".
6011:
5766:
5557:
5276:
5149:
3386:
Peer CJ, Schmidt KT, Kindrick JD, Eisner JR, Brown VV, Baskin-Bey E, et al. (October 2019).
2995:
Bonomo S, Hansen CH, Petrunak EM, Scott EE, Styrishave B, Jørgensen FS, et al. (July 2016).
1693:
1635:
and other lipids and are involved in drug metabolism. CYP17A1 has both 17α-hydroxylase activity (
1479:
2280:"Cytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMR"
1226:
1205:
1179:
1158:
5905:
5821:
5570:
5103:
5048:
5044:
5010:
4942:
4524:
3845:
3152:
Fernández-Cancio M, Camats N, Flück CE, Zalewski A, Dick B, Frey BM, et al. (April 2018).
1666:
2585:"Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17"
385:
6032:
5951:
5701:
5674:
5509:
5340:
4846:
3807:
2200:
Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, et al. (June 2015).
1844:, showing, at left side, both reactions of 17α-hydroxylase, and both actions of 17, 20 lyase.
1670:
1624:
1396:(-OH) group at carbon 17 position (C17) of the steroid D ring (the 17α-hydroxylase activity,
1341:
421:
363:
113:
2837:
Legendre A, Elie C, Ramambason C, Manens L, Souidi M, Froment P, et al. (August 2016).
1692:
via pregnenolone to17-OHPreg and DHEA by the CYP17A1 requires POR. Human CYP17A1 protein is
6104:
5816:
5779:
5540:
5531:
5298:
5195:
5066:
4965:
4606:
3979:
3860:
3521:
3226:
3008:
2849:
2640:
2498:
2342:
1949:
89:
39:
8:
6068:
5802:
5450:
5156:
4984:
3850:
3616:
3448:
Miura K, Yasuda K, Yanase T, Yamakita N, Sasano H, Nawata H, et al. (October 1996).
1811:
1771:
1495:
46:
3525:
3337:
Madan RA, Schmidt KT, Karzai F, Peer CJ, Cordes LM, Chau CH, et al. (August 2020).
3230:
3012:
2853:
2644:
2502:
2346:
6001:
5565:
4950:
4165:
3681:
3673:
3545:
3425:
3412:
3387:
3363:
3338:
3310:
3285:
3247:
3215:"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001"
3214:
3180:
3153:
3129:
3104:
3080:
3053:
3029:
2996:
2974:
2925:
2900:
2758:
2717:
2519:
2487:"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001"
2486:
2467:
2414:
2387:
2363:
2331:"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001"
2330:
2306:
2279:
2226:
2201:
2174:
2149:
1587:. In addition to classical steroidogenic tissue, CYP17A1 has also been detected in the
367:
5711:
4051:
2217:
1814:, that permanently (rather than competitively) disables CYP17A1, once it binds to it.
958:
953:
948:
943:
938:
933:
928:
923:
907:
902:
897:
892:
887:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
5599:
4259:
4176:
4106:
3771:
3752:
3574:
3537:
3500:
3471:
3429:
3417:
3368:
3315:
3252:
3203:
3185:
3134:
3085:
3034:
2978:
2966:
2930:
2867:
2819:
2762:
2709:
2668:
2663:
2628:
2606:
2565:
2524:
2459:
2419:
2368:
2311:
2231:
2179:
2125:
1821:
1807:
1756:
1369:
315:
239:
144:
3549:
2721:
1888:
1860:
6047:
6042:
6016:
5944:
4184:
3704:
3657:
3566:
3529:
3492:
3461:
3407:
3399:
3358:
3350:
3305:
3297:
3242:
3234:
3175:
3165:
3124:
3116:
3075:
3065:
3024:
3016:
2962:
2958:
2920:
2912:
2857:
2811:
2748:
2699:
2658:
2648:
2596:
2555:
2514:
2506:
2471:
2451:
2409:
2399:
2358:
2350:
2301:
2291:
2221:
2213:
2169:
2161:
1584:
1553:
1549:
1541:
1353:
1349:
1345:
626:
557:
501:
456:
2815:
347:
6094:
6078:
5991:
5689:
5399:
4268:
3936:
2544:"Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis"
2088:
1841:
1685:
1620:
1534:
1519:
1471:, including the remarkable carbon-carbon bond scission catalyzed by this enzyme.
1452:
601:
371:
3301:
2165:
2039:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2021:
National Center for
Biotechnology Information, U.S. National Library of Medicine
6132:
6073:
5915:
5895:
5890:
5532:
4707:
4046:
3965:
3744:
3466:
3449:
3403:
3354:
3054:"Disorders of Sex Development: Classification, Review, and Impact on Fertility"
2633:
Proceedings of the
National Academy of Sciences of the United States of America
2560:
2543:
1941:
1793:
1650:
1596:
1580:
1557:
1455:
superfamily of enzymes. The cytochrome P450 proteins are generally regarded as
1373:
1357:
702:
172:
3570:
3496:
3286:"The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature"
2916:
2862:
2455:
784:
6231:
6037:
5996:
5482:
5386:
5347:
5269:
5262:
5248:
5208:
5189:
5163:
2901:"Structural insights into the function of steroidogenic cytochrome P450 17A1"
2777:"Entrez Gene: CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1"
2653:
1649:). The 17α-hydroxylase activity of CYP17A1 is required for the generation of
1577:
1538:
1456:
1344:. It is ubiquitously expressed in many tissues and cell types, including the
1330:
813:
326:, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1
3533:
2753:
2736:
2404:
2296:
762:
640:
5986:
5734:
5730:
5005:
4979:
4883:
4869:
4862:
4768:
4748:
4741:
4724:
4666:
4649:
4642:
4635:
4628:
4621:
4589:
4582:
3946:
3578:
3541:
3421:
3372:
3319:
3256:
3189:
3138:
3120:
3089:
3038:
2970:
2934:
2871:
2823:
2713:
2610:
2601:
2584:
2569:
2528:
2463:
2423:
2372:
2315:
2235:
2183:
1894:
1866:
1803:
1763:
1689:
1658:
1389:
1385:
619:
398:
3504:
3475:
2672:
1646:
1639:
1459:
that catalyze many reactions involved in drug metabolism and synthesis of
1419:
1400:
1290:
1285:
101:
6210:
6145:
5981:
4575:
4531:
4062:
3974:
3889:
3822:
3733:
3715:
3665:
2249:
2059:
1817:
1628:
1569:
1561:
1523:
1511:
1499:
1460:
1133:
1114:
3238:
2510:
2388:"Structures of human steroidogenic cytochrome P450 17A1 with substrates"
2354:
1627:. Proteins in this family are monooxygenases that catalyze synthesis of
5866:
4260:
3832:
3653:
3170:
3070:
2704:
2687:
1786:
1515:
518:
415:
351:
3207:
3020:
292:
288:
284:
280:
276:
272:
268:
6184:
6158:
5835:
5798:
5742:
5536:
5475:
4676:
4264:
4170:
4137:
3991:
3913:
1507:
1448:
1365:
988:
585:
572:
484:
471:
359:
5614:
5432:
5392:
5379:
5324:
5291:
5241:
5219:
5214:
5200:
4129:
4072:
3987:
3699:
3151:
1935:
1654:
1565:
1545:
1393:
1381:
1377:
1274:
2542:
Udhane SS, Dick B, Hu Q, Hartmann RW, Pandey AV (September 2016).
1837:
4901:
4828:
4818:
4808:
4791:
4781:
4773:
4761:
4757:
4753:
4734:
4686:
4614:
4610:
4598:
4489:
4484:
4479:
4454:
4449:
4433:
4353:
4348:
4328:
4195:
4190:
3926:
3691:
3669:
1680:
Furthermore, the 17,20-lyase activity is dependent on cytochrome
1632:
1478:
gene may also contain variants associated with increased risk of
1464:
1439:
gene resides on chromosome 10 at the band 10q24.3 and contains 8
1100:
1055:
973:
969:
120:
1732:
Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency
339:
6197:
5967:
5752:
5747:
5706:
4568:
4564:
4554:
4540:
4536:
4504:
4499:
4494:
4474:
4469:
4464:
4459:
4423:
4418:
4413:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4343:
4338:
4333:
4323:
4318:
4302:
4292:
4287:
4116:
4111:
4039:
4034:
3661:
2947:
2441:
2386:
Petrunak EM, DeVore NM, Porubsky PR, Scott EE (November 2014).
1608:
1604:
1592:
1326:
1258:
1010:
793:
184:
96:
84:
72:
6171:
5899:
5634:
5592:
5585:
5580:
5575:
4855:
4717:
4404:
1782:
iron through its pyridine nitrogen, mimicking the substrate.
1600:
1588:
1573:
1468:
1412:
1361:
2899:
Yadav R, Petrunak EM, Estrada DF, Scott EE (February 2017).
2836:
5679:
5667:
5662:
5652:
5647:
5630:
5604:
4909:
2385:
1779:
1503:
1444:
1440:
1411:
to split the side-chain off the steroid nucleus (the 17,20-
1337:
108:
5936:
2627:
Zhang LH, Rodriguez H, Ohno S, Miller WL (November 1995).
3447:
3385:
3290:
The
Journal of Steroid Biochemistry and Molecular Biology
3273:(Press release). Tokai Pharmaceuticals. January 29, 2014.
2994:
2898:
2154:
The
Journal of Steroid Biochemistry and Molecular Biology
1708:
Mutations in this gene are associated with rare forms of
1491:
3556:
2685:
2626:
2199:
609:
222:
3336:
3103:
Bordeau BM, Ciulla DA, Callahan BP (September 2016).
3102:
2686:
Fukami M, Homma K, Hasegawa T, Ogata T (April 2013).
2122:
Medical physiology: a cellular and molecular approach
774:
4144:
4100:
4092:
4028:
4003:
3454:
The
Journal of Clinical Endocrinology and Metabolism
2541:
2277:
2119:
1931:
1537:
of CYP17A1 has been found in all of the traditional
2548:
2278:Estrada DF, Laurence JS, Scott EE (February 2016).
2115:
2113:
3482:
2124:. St. Louis, Mo: Elsevier Saunders. p. 1180.
1995:
1993:
1991:
1974:
1972:
1970:
2147:
1762:pose a liability in terms of side effects. Using
1714:17α-hydroxylase deficiency/17,20-lyase deficiency
556:
455:
6229:
2110:
2437:
2435:
2433:
1988:
1967:
2990:
2988:
2150:"CYP17 inhibitors for prostate cancer therapy"
2000:GRCm38: Ensembl release 89: ENSMUSG00000003555
872:17-alpha-hydroxyprogesterone aldolase activity
5952:
5517:
4245:
3638:
2734:
2622:
2620:
3379:
3330:
3277:
3196:
3045:
2800:
2582:
2430:
2195:
2193:
3212:
2985:
2484:
2328:
2148:Vasaitis TS, Bruno RD, Njar VC (May 2011).
1979:GRCh38: Ensembl release 89: ENSG00000148795
1603:, CYP17A1 has been reported in the kidney,
5959:
5945:
5524:
5510:
4252:
4238:
3645:
3631:
3514:Annals of the New York Academy of Sciences
3283:
3051:
2617:
1384:. More specifically, the enzyme acts upon
3596:at the U.S. National Library of Medicine
3465:
3411:
3362:
3309:
3263:
3246:
3179:
3169:
3128:
3079:
3069:
3028:
2924:
2861:
2752:
2703:
2662:
2652:
2600:
2559:
2518:
2413:
2403:
2362:
2305:
2295:
2225:
2190:
2173:
1955:Cytochrome P450 oxidoreductase deficiency
3841:Farnesyl-diphosphate farnesyltransferase
1836:
1703:
1623:superfamily of enzymes localized in the
24:Steroid 17-alpha-hydroxylase/17,20 lyase
3787:Isopentenyl-diphosphate delta isomerase
3511:
842:steroid 17-alpha-monooxygenase activity
16:Mammalian protein found in Homo sapiens
6230:
4205:Steroidogenic acute regulatory protein
1696:on serine and threonine residues by a
1333:type that in humans is encoded by the
5940:
5505:
4233:
3626:
1750:
1498:. As an enzyme, CYP17A1 possesses an
561:
522:
517:
460:
419:
414:
5717:24-hydroxycholesterol 7α-hydroxylase
3392:Cancer Chemotherapy and Pharmacology
3213:DeVore NM, Scott EE (January 2012).
2905:Molecular and Cellular Endocrinology
2485:DeVore NM, Scott EE (January 2012).
2444:Molecular and Cellular Endocrinology
2329:DeVore NM, Scott EE (January 2012).
2143:
2141:
2054:
2052:
2050:
2048:
1852:
1798:castration-resistant prostate cancer
1776:castration-resistant prostate cancer
1451:. This gene encodes a member of the
1447:of this gene spans a length of 1527
3782:Pyrophosphomevalonate decarboxylase
3700:Acetyl-Coenzyme A acetyltransferase
3284:Bird IM, Abbott DH (October 2016).
2589:The Journal of Biological Chemistry
2583:Pandey AV, Miller WL (April 2005).
2392:The Journal of Biological Chemistry
2284:The Journal of Biological Chemistry
1745:
934:glucocorticoid biosynthetic process
13:
3440:
3052:Acién P, Acién M (November 2020).
2728:
2089:"BioGPS - your Gene Portal System"
1828:
1736:
14:
6259:
3587:
2138:
2045:
386:1.14.14.32 1.14.14.19, 1.14.14.32
1934:
1915:
1901:
1887:
1873:
1859:
783:
545:
538:
532:
509:
444:
437:
431:
406:
221:
5697:Cholesterol 7 alpha-hydroxylase
5643:Flavin-containing monooxygenase
3955:Cholesterol side-chain cleavage
3899:24-Dehydrocholesterol reductase
3729:3-hydroxybutyrate dehydrogenase
3145:
3096:
2941:
2892:
2881:from the original on 2024-02-02
2830:
2794:
2783:from the original on 2010-03-07
2769:
2737:"Alternative androgen pathways"
2679:
2576:
2535:
2478:
2379:
2322:
2271:
2260:from the original on 2016-10-12
2242:
2120:Boulpaep EL, Boron, WF (2005).
2099:from the original on 2011-08-20
2070:from the original on 2015-06-23
1718:isolated 17,20-lyase deficiency
1684:(POR) cytochrome b5 (CYB5) and
3880:7-Dehydrocholesterol reductase
2963:10.1016/j.steroids.2016.06.002
2081:
2027:
2009:
1725:congenital adrenal hyperplasia
1710:congenital adrenal hyperplasia
924:progesterone metabolic process
888:endoplasmic reticulum membrane
794:More reference expression data
763:More reference expression data
1:
4215:Reverse cholesterol transport
3803:Dimethylallyltranstransferase
3343:Clinical Genitourinary Cancer
2816:10.1016/j.aquatox.2016.08.006
2218:10.1016/S0140-6736(14)61730-X
1960:
1698:cAMP-dependent protein kinase
1667:dehydroepiandrosterone (DHEA)
1529:
929:androgen biosynthetic process
530:
429:
6248:Steroid hormone biosynthesis
6238:Genes on human chromosome 10
3559:Journal of Molecular Biology
3058:Journal of Clinical Medicine
2735:Masiutin M, Yadav M (2023).
1642:) and 17,20-lyase activity (
1425:
949:steroid biosynthetic process
944:hormone biosynthetic process
7:
5966:
5926:Deoxyhypusine monooxygenase
4210:Cholesterol total synthesis
3302:10.1016/j.jsbmb.2016.04.021
2166:10.1016/j.jsbmb.2010.11.005
1927:
1661:sex steroids by converting
1619:CYP17A1 is a member of the
1614:
10:
6264:
3922:Cholesterol 7α-hydroxylase
3870:Lanosterol 14α-demethylase
3615:gene details page in the
3467:10.1210/jcem.81.10.8855840
3404:10.1007/s00280-019-03908-0
3355:10.1016/j.clgc.2019.11.002
2561:10.1016/j.bbrc.2016.07.019
1754:
1729:
1485:
1244:Chr 10: 102.83 – 102.84 Mb
687:left lobe of thyroid gland
6123:
6115:Michaelis–Menten kinetics
6087:
6056:
6025:
5974:
5921:Ecdysone 20-monooxygenase
5880:
5872:Stearoyl-CoA desaturase-1
5852:
5844:Dopamine beta-hydroxylase
5830:
5812:Phenylalanine hydroxylase
5793:
5761:
5725:
5625:
5552:
5467:
5442:
5371:
5141:
4919:
4838:
4696:
4513:
4442:
4402:
4311:
4280:
4158:
4127:
4070:
4060:
3963:
3944:
3935:
3911:
3888:
3875:Sterol-C5-desaturase-like
3859:
3830:
3820:
3795:
3761:
3742:
3714:
3689:
3680:
3571:10.1016/j.jmb.2010.05.069
3497:10.3109/07435809809032692
2917:10.1016/j.mce.2016.08.035
2863:10.1016/j.tox.2016.08.014
2456:10.1016/j.mce.2010.11.016
2035:"Mouse PubMed Reference:"
2017:"Human PubMed Reference:"
1774:, which is used to treat
1576:, and, more recently, in
1307:steroid 17α-monooxygenase
1289:
1284:
1280:
1273:
1257:
1238:
1223:
1219:
1202:
1198:
1191:
1176:
1172:
1155:
1151:
1144:
1131:
1127:
1112:
1108:
1099:
1086:
1082:
1067:
1063:
1054:
1041:
1037:
1022:
1018:
1009:
994:
987:
983:
967:
954:steroid metabolic process
812:
808:
791:
782:
773:
760:
709:
700:
647:
638:
608:
600:
596:
579:
566:
529:
508:
499:
495:
478:
465:
428:
405:
396:
392:
383:
378:
333:
330:
320:
313:
308:
265:
260:
243:
238:
233:
229:
220:
215:
195:
183:
171:
166:
162:
143:
131:
119:
107:
95:
83:
71:
66:
57:
45:
33:
28:
23:
6007:Diffusion-limited enzyme
3777:Phosphomevalonate kinase
3598:Medical Subject Headings
2654:10.1073/pnas.92.23.10619
1251:Chr 19: 46.66 – 46.66 Mb
939:sterol metabolic process
741:epithelium of epididymis
3534:10.1196/annals.1290.005
2741:WikiJournal of Medicine
2405:10.1074/jbc.M114.610998
2297:10.1074/jbc.M115.677294
1909:17α-Hydroxyprogesterone
1881:17α-Hydroxypregnenolone
1663:17α-hydroxypregnenolone
1502:that associates with a
1480:coronary artery disease
1430:
1409:17α-hydroxypregnenolone
1405:17α-hydroxyprogesterone
867:oxidoreductase activity
5906:Squalene monooxygenase
5822:Tryptophan hydroxylase
5571:HIF prolyl-hydroxylase
3846:Squalene monooxygenase
3594:CYP17A1+protein,+human
3121:10.1002/cmdc.201600238
2692:Developmental Dynamics
2602:10.1074/jbc.M414673200
1845:
847:monooxygenase activity
563:19 C3|19 38.97 cM
6100:Eadie–Hofstee diagram
6033:Allosteric regulation
5702:Methane monooxygenase
5675:Nitric oxide synthase
3927:Sterol 27-hydroxylase
3808:Geranyl pyrophosphate
2754:10.15347/WJM/2023.003
1840:
1704:Clinical significance
1671:pseudohermaphroditism
1625:endoplasmic reticulum
908:endoplasmic reticulum
683:right coronary artery
524:Chromosome 19 (mouse)
422:Chromosome 10 (human)
6110:Lineweaver–Burk plot
5817:Tyrosine hydroxylase
5541:steroid hydroxylases
3861:7-Dehydrocholesterol
3609:genome location and
2064:www.ncbi.nlm.nih.gov
1950:Steroidogenic enzyme
1820:(VT-464) is a novel
1315:17-alpha-hydroxylase
1303:Cytochrome P450 17A1
655:right adrenal cortex
261:List of PDB id codes
234:Available structures
5767:iron–sulfur protein
3851:Lanosterol synthase
3617:UCSC Genome Browser
3526:2003NYASA.997...42S
3239:10.1038/nature10743
3231:2012Natur.482..116D
3013:2016NatSR...629468B
2854:2016Toxgy.368...58L
2645:1995PNAS...9210619Z
2639:(23): 10619–10623.
2595:(14): 13265–13271.
2511:10.1038/nature10743
2503:2012Natur.482..116D
2398:(47): 32952–32964.
2355:10.1038/nature10743
2347:2012Natur.482..116D
2212:(9984): 2264–2271.
1812:abiraterone acetate
1772:abiraterone acetate
1682:P450 oxidoreductase
1675:adrenal hyperplasia
1496:amino acid residues
959:sex differentiation
725:seminiferous tubule
675:right lobe of liver
659:left adrenal cortex
651:right adrenal gland
372:CYP17A1 - orthologs
6069:Enzyme superfamily
6002:Enzyme promiscuity
5566:Prolyl hydroxylase
4166:Steroid metabolism
3682:Mevalonate pathway
3674:steroid metabolism
3485:Endocrine Research
3171:10.3390/ph11020037
3071:10.3390/jcm9113555
3001:Scientific Reports
2848:. 368–369: 58–68.
2804:Aquatic Toxicology
2705:10.1002/dvdy.23892
1846:
1751:CYP17A1 inhibitors
1490:CYP17A1 is a 57.4
1370:mineralocorticoids
1089:ENSMUSG00000003555
917:Biological process
903:neuronal cell body
881:Cellular component
820:Molecular function
671:right uterine tube
6225:
6224:
5934:
5933:
5600:Lysyl hydroxylase
5499:
5498:
4227:
4226:
4223:
4222:
4177:Steroid sulfatase
4154:
4153:
3907:
3906:
3816:
3815:
3772:Mevalonate kinase
3753:HMG-CoA reductase
3460:(10): 3797–3801.
3349:(4): 258–267.e1.
3225:(7383): 116–119.
3115:(18): 1983–1986.
3021:10.1038/srep29468
2497:(7383): 116–119.
2341:(7383): 116–119.
1922:Steroid numbering
1853:Additional images
1850:
1849:
1822:CYP17A1 inhibitor
1808:CYP17A1 inhibitor
1757:CYP17A1 inhibitor
1585:ovarian follicles
1300:
1299:
1296:
1295:
1269:
1268:
1234:
1233:
1213:
1212:
1187:
1186:
1166:
1165:
1140:
1139:
1121:
1120:
1095:
1094:
1076:
1075:
1050:
1049:
1031:
1030:
979:
978:
837:metal ion binding
804:
803:
800:
799:
769:
768:
756:
755:
694:
693:
592:
591:
491:
490:
304:
303:
300:
299:
244:Ortholog search:
211:
210:
207:
206:
126:metabolic pathway
6255:
6105:Hanes–Woolf plot
6048:Enzyme activator
6043:Enzyme inhibitor
6017:Enzyme catalysis
5961:
5954:
5947:
5938:
5937:
5526:
5519:
5512:
5503:
5502:
4271:(Most belong to
4254:
4247:
4240:
4231:
4230:
4185:sulfotransferase
4146:
4102:
4094:
4068:
4067:
4030:
4005:
3942:
3941:
3828:
3827:
3707:(regulated step)
3705:HMG-CoA synthase
3687:
3686:
3658:lipid metabolism
3647:
3640:
3633:
3624:
3623:
3582:
3565:(5): 1078–1098.
3553:
3508:
3491:(3–4): 817–825.
3479:
3469:
3434:
3433:
3415:
3383:
3377:
3376:
3366:
3334:
3328:
3327:
3313:
3281:
3275:
3274:
3267:
3261:
3260:
3250:
3210:
3200:
3194:
3193:
3183:
3173:
3149:
3143:
3142:
3132:
3100:
3094:
3093:
3083:
3073:
3049:
3043:
3042:
3032:
2992:
2983:
2982:
2945:
2939:
2938:
2928:
2896:
2890:
2889:
2887:
2886:
2880:
2865:
2843:
2834:
2828:
2827:
2798:
2792:
2791:
2789:
2788:
2773:
2767:
2766:
2756:
2732:
2726:
2725:
2707:
2683:
2677:
2676:
2666:
2656:
2624:
2615:
2614:
2604:
2580:
2574:
2573:
2563:
2554:(4): 1005–1010.
2539:
2533:
2532:
2522:
2482:
2476:
2475:
2439:
2428:
2427:
2417:
2407:
2383:
2377:
2376:
2366:
2326:
2320:
2319:
2309:
2299:
2290:(8): 3990–4003.
2275:
2269:
2268:
2266:
2265:
2246:
2240:
2239:
2229:
2197:
2188:
2187:
2177:
2145:
2136:
2135:
2117:
2108:
2107:
2105:
2104:
2085:
2079:
2078:
2076:
2075:
2056:
2043:
2042:
2031:
2025:
2024:
2013:
2007:
1997:
1986:
1976:
1944:
1939:
1938:
1919:
1905:
1891:
1877:
1863:
1833:
1832:
1746:As a drug target
1554:zona fasciculata
1550:zona reticularis
1548:, including the
1403:), or acts upon
1354:zona glomerulosa
1350:zona fasciculata
1346:zona reticularis
1282:
1281:
1253:
1246:
1229:
1217:
1216:
1208:
1196:
1195:
1192:RefSeq (protein)
1182:
1170:
1169:
1161:
1149:
1148:
1125:
1124:
1106:
1105:
1080:
1079:
1061:
1060:
1035:
1034:
1016:
1015:
985:
984:
827:iron ion binding
810:
809:
796:
787:
780:
779:
765:
705:
703:Top expressed in
698:
697:
643:
641:Top expressed in
636:
635:
615:
614:
598:
597:
588:
575:
564:
549:
542:
536:
525:
513:
497:
496:
487:
474:
463:
448:
441:
435:
424:
410:
394:
393:
388:
374:
325:
318:
295:
258:
257:
252:
231:
230:
225:
213:
212:
164:
163:
21:
20:
6263:
6262:
6258:
6257:
6256:
6254:
6253:
6252:
6243:Cytochrome P450
6228:
6227:
6226:
6221:
6133:Oxidoreductases
6119:
6095:Enzyme kinetics
6083:
6079:List of enzymes
6052:
6021:
5992:Catalytic triad
5970:
5965:
5935:
5930:
5884:- miscellaneous
5876:
5848:
5826:
5789:
5757:
5721:
5712:14α-demethylase
5621:
5548:
5533:Oxidoreductases
5530:
5500:
5495:
5463:
5438:
5400:Halloween genes
5367:
5137:
4915:
4834:
4692:
4509:
4438:
4398:
4307:
4276:
4269:cytochrome P450
4258:
4228:
4219:
4159:Other/ungrouped
4150:
4123:
4081:17α-Hydroxylase
4056:
4052:11β-Hydroxylase
3997:17α-Hydroxylase
3966:corticosteroids
3959:
3937:Steroidogenesis
3931:
3903:
3884:
3855:
3812:
3791:
3757:
3738:
3710:
3676:
3651:
3590:
3585:
3443:
3441:Further reading
3438:
3437:
3384:
3380:
3335:
3331:
3282:
3278:
3269:
3268:
3264:
3202:
3201:
3197:
3158:Pharmaceuticals
3150:
3146:
3101:
3097:
3050:
3046:
2993:
2986:
2946:
2942:
2897:
2893:
2884:
2882:
2878:
2841:
2835:
2831:
2799:
2795:
2786:
2784:
2775:
2774:
2770:
2733:
2729:
2684:
2680:
2625:
2618:
2581:
2577:
2540:
2536:
2483:
2479:
2450:(1–2): 92–101.
2440:
2431:
2384:
2380:
2327:
2323:
2276:
2272:
2263:
2261:
2254:www.uniprot.org
2248:
2247:
2243:
2198:
2191:
2146:
2139:
2132:
2118:
2111:
2102:
2100:
2087:
2086:
2082:
2073:
2071:
2058:
2057:
2046:
2033:
2032:
2028:
2015:
2014:
2010:
1998:
1989:
1977:
1968:
1963:
1940:
1933:
1930:
1923:
1920:
1911:
1906:
1897:
1892:
1883:
1878:
1869:
1864:
1855:
1842:Steroidogenesis
1831:
1829:Steroidogenesis
1794:clinical trials
1759:
1753:
1748:
1739:
1737:Clinical marker
1734:
1712:, specifically
1706:
1686:phosphorylation
1651:glucocorticoids
1621:cytochrome P450
1617:
1581:granulosa cells
1532:
1520:steroidogenesis
1488:
1453:cytochrome P450
1433:
1428:
1374:glucocorticoids
1323:17,20-desmolase
1311:17α-hydroxylase
1291:View/Edit Mouse
1286:View/Edit Human
1249:
1242:
1239:Location (UCSC)
1225:
1204:
1178:
1157:
1070:ENSG00000148795
963:
912:
876:
792:
761:
752:
747:
743:
739:
737:theca folliculi
735:
731:
727:
723:
719:
715:
701:
690:
685:
681:
677:
673:
669:
665:
661:
657:
653:
639:
583:
570:
562:
552:
551:
550:
543:
523:
500:Gene location (
482:
469:
461:
451:
450:
449:
442:
420:
397:Gene location (
384:
334:
321:
314:
267:
245:
17:
12:
11:
5:
6261:
6251:
6250:
6245:
6240:
6223:
6222:
6220:
6219:
6206:
6193:
6180:
6167:
6154:
6141:
6127:
6125:
6121:
6120:
6118:
6117:
6112:
6107:
6102:
6097:
6091:
6089:
6085:
6084:
6082:
6081:
6076:
6071:
6066:
6060:
6058:
6057:Classification
6054:
6053:
6051:
6050:
6045:
6040:
6035:
6029:
6027:
6023:
6022:
6020:
6019:
6014:
6009:
6004:
5999:
5994:
5989:
5984:
5978:
5976:
5972:
5971:
5964:
5963:
5956:
5949:
5941:
5932:
5931:
5929:
5928:
5923:
5918:
5913:
5908:
5903:
5896:Heme oxygenase
5893:
5891:Cyclooxygenase
5887:
5885:
5878:
5877:
5875:
5874:
5869:
5863:
5861:
5850:
5849:
5847:
5846:
5840:
5838:
5828:
5827:
5825:
5824:
5819:
5814:
5808:
5806:
5791:
5790:
5788:
5787:
5782:
5777:
5771:
5769:
5759:
5758:
5756:
5755:
5750:
5745:
5739:
5737:
5723:
5722:
5720:
5719:
5714:
5709:
5704:
5699:
5694:
5693:
5692:
5687:
5682:
5672:
5671:
5670:
5665:
5660:
5655:
5650:
5639:
5637:
5623:
5622:
5620:
5619:
5618:
5617:
5612:
5602:
5597:
5596:
5595:
5590:
5589:
5588:
5583:
5578:
5562:
5560:
5558:2-oxoglutarate
5550:
5549:
5529:
5528:
5521:
5514:
5506:
5497:
5496:
5494:
5493:
5486:
5479:
5471:
5469:
5465:
5464:
5462:
5461:
5454:
5446:
5444:
5440:
5439:
5437:
5436:
5429:
5397:
5396:
5395:
5383:
5375:
5373:
5369:
5368:
5366:
5365:
5358:
5351:
5344:
5337:
5330:
5329:
5328:
5321:
5309:
5302:
5295:
5288:
5287:
5286:
5283:
5273:
5266:
5259:
5252:
5245:
5238:
5231:
5224:
5223:
5222:
5217:
5205:
5204:
5203:
5198:
5186:
5179:
5178:
5177:
5172:
5160:
5153:
5145:
5143:
5139:
5138:
5136:
5135:
5128:
5121:
5114:
5107:
5100:
5078:
5060:
5018:
5002:
4988:
4976:
4969:
4962:
4923:
4921:
4917:
4916:
4914:
4913:
4906:
4905:
4904:
4894:
4893:
4892:
4880:
4879:
4878:
4866:
4859:
4842:
4840:
4836:
4835:
4833:
4832:
4822:
4812:
4802:
4795:
4785:
4765:
4745:
4738:
4728:
4721:
4711:
4700:
4698:
4694:
4693:
4691:
4690:
4680:
4670:
4663:
4653:
4646:
4639:
4632:
4625:
4618:
4586:
4579:
4572:
4558:
4544:
4528:
4517:
4515:
4511:
4510:
4508:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4446:
4444:
4440:
4439:
4437:
4436:
4431:
4426:
4421:
4416:
4410:
4408:
4400:
4399:
4397:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4331:
4326:
4321:
4315:
4313:
4309:
4308:
4306:
4305:
4300:
4295:
4290:
4284:
4282:
4278:
4277:
4257:
4256:
4249:
4242:
4234:
4225:
4224:
4221:
4220:
4218:
4217:
4212:
4207:
4201:
4200:
4199:
4198:
4193:
4181:
4180:
4179:
4162:
4160:
4156:
4155:
4152:
4151:
4149:
4148:
4140:
4134:
4132:
4125:
4124:
4122:
4121:
4120:
4119:
4114:
4104:
4096:
4088:
4083:
4077:
4075:
4065:
4058:
4057:
4055:
4054:
4049:
4047:21-Hydroxylase
4044:
4043:
4042:
4037:
4020:
4019:
4018:
4017:
4012:
3999:
3983:
3982:
3980:18-Hydroxylase
3970:
3968:
3961:
3960:
3958:
3957:
3951:
3949:
3939:
3933:
3932:
3930:
3929:
3924:
3918:
3916:
3909:
3908:
3905:
3904:
3902:
3901:
3895:
3893:
3886:
3885:
3883:
3882:
3877:
3872:
3866:
3864:
3857:
3856:
3854:
3853:
3848:
3843:
3837:
3835:
3825:
3818:
3817:
3814:
3813:
3811:
3810:
3805:
3799:
3797:
3793:
3792:
3790:
3789:
3784:
3779:
3774:
3768:
3766:
3759:
3758:
3756:
3755:
3749:
3747:
3745:Mevalonic acid
3740:
3739:
3737:
3736:
3731:
3726:
3720:
3718:
3712:
3711:
3709:
3708:
3702:
3696:
3694:
3684:
3678:
3677:
3650:
3649:
3642:
3635:
3627:
3621:
3620:
3601:
3589:
3588:External links
3586:
3584:
3583:
3554:
3509:
3480:
3444:
3442:
3439:
3436:
3435:
3398:(4): 759–770.
3378:
3329:
3276:
3262:
3195:
3144:
3095:
3044:
2984:
2940:
2891:
2829:
2793:
2768:
2727:
2698:(4): 320–329.
2678:
2616:
2575:
2534:
2477:
2429:
2378:
2321:
2270:
2241:
2189:
2160:(1–2): 23–31.
2137:
2130:
2109:
2080:
2044:
2026:
2008:
1987:
1965:
1964:
1962:
1959:
1958:
1957:
1952:
1946:
1945:
1942:Biology portal
1929:
1926:
1925:
1924:
1921:
1914:
1912:
1907:
1900:
1898:
1893:
1886:
1884:
1879:
1872:
1870:
1865:
1858:
1854:
1851:
1848:
1847:
1830:
1827:
1755:Main article:
1752:
1749:
1747:
1744:
1738:
1735:
1705:
1702:
1694:phosphorylated
1616:
1613:
1597:adipose tissue
1558:adrenal cortex
1531:
1528:
1487:
1484:
1457:monooxygenases
1432:
1429:
1427:
1424:
1358:adrenal cortex
1298:
1297:
1294:
1293:
1288:
1278:
1277:
1271:
1270:
1267:
1266:
1264:
1262:
1255:
1254:
1247:
1240:
1236:
1235:
1232:
1231:
1221:
1220:
1214:
1211:
1210:
1200:
1199:
1193:
1189:
1188:
1185:
1184:
1174:
1173:
1167:
1164:
1163:
1153:
1152:
1146:
1142:
1141:
1138:
1137:
1129:
1128:
1122:
1119:
1118:
1110:
1109:
1103:
1097:
1096:
1093:
1092:
1084:
1083:
1077:
1074:
1073:
1065:
1064:
1058:
1052:
1051:
1048:
1047:
1039:
1038:
1032:
1029:
1028:
1020:
1019:
1013:
1007:
1006:
1001:
996:
992:
991:
981:
980:
977:
976:
965:
964:
962:
961:
956:
951:
946:
941:
936:
931:
926:
920:
918:
914:
913:
911:
910:
905:
900:
895:
890:
884:
882:
878:
877:
875:
874:
869:
864:
862:lyase activity
859:
854:
849:
844:
839:
834:
832:oxygen binding
829:
823:
821:
817:
816:
806:
805:
802:
801:
798:
797:
789:
788:
777:
771:
770:
767:
766:
758:
757:
754:
753:
751:
750:
746:
742:
738:
734:
730:
729:adrenal cortex
726:
722:
718:
714:
710:
707:
706:
695:
692:
691:
689:
688:
684:
680:
676:
672:
668:
664:
660:
656:
652:
648:
645:
644:
632:
631:
623:
612:
606:
605:
602:RNA expression
594:
593:
590:
589:
581:
577:
576:
568:
565:
560:
554:
553:
544:
537:
531:
527:
526:
521:
515:
514:
506:
505:
493:
492:
489:
488:
480:
476:
475:
467:
464:
459:
453:
452:
443:
436:
430:
426:
425:
418:
412:
411:
403:
402:
390:
389:
382:
376:
375:
332:
328:
327:
319:
311:
310:
306:
305:
302:
301:
298:
297:
263:
262:
254:
253:
242:
236:
235:
227:
226:
218:
217:
209:
208:
205:
204:
199:
193:
192:
187:
181:
180:
175:
169:
168:
160:
159:
148:
141:
140:
135:
129:
128:
123:
117:
116:
111:
105:
104:
99:
93:
92:
87:
81:
80:
75:
69:
68:
64:
63:
59:
55:
54:
49:
43:
42:
37:
31:
30:
26:
25:
15:
9:
6:
4:
3:
2:
6260:
6249:
6246:
6244:
6241:
6239:
6236:
6235:
6233:
6217:
6213:
6212:
6207:
6204:
6200:
6199:
6194:
6191:
6187:
6186:
6181:
6178:
6174:
6173:
6168:
6165:
6161:
6160:
6155:
6152:
6148:
6147:
6142:
6139:
6135:
6134:
6129:
6128:
6126:
6122:
6116:
6113:
6111:
6108:
6106:
6103:
6101:
6098:
6096:
6093:
6092:
6090:
6086:
6080:
6077:
6075:
6074:Enzyme family
6072:
6070:
6067:
6065:
6062:
6061:
6059:
6055:
6049:
6046:
6044:
6041:
6039:
6038:Cooperativity
6036:
6034:
6031:
6030:
6028:
6024:
6018:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5998:
5997:Oxyanion hole
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5979:
5977:
5973:
5969:
5962:
5957:
5955:
5950:
5948:
5943:
5942:
5939:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5907:
5904:
5901:
5897:
5894:
5892:
5889:
5888:
5886:
5883:
5879:
5873:
5870:
5868:
5865:
5864:
5862:
5859:
5855:
5851:
5845:
5842:
5841:
5839:
5837:
5833:
5829:
5823:
5820:
5818:
5815:
5813:
5810:
5809:
5807:
5804:
5803:BH4 dependent
5800:
5796:
5792:
5786:
5783:
5781:
5778:
5776:
5773:
5772:
5770:
5768:
5764:
5760:
5754:
5751:
5749:
5746:
5744:
5741:
5740:
5738:
5736:
5732:
5728:
5724:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5691:
5688:
5686:
5683:
5681:
5678:
5677:
5676:
5673:
5669:
5666:
5664:
5661:
5659:
5656:
5654:
5651:
5649:
5646:
5645:
5644:
5641:
5640:
5638:
5636:
5632:
5628:
5624:
5616:
5613:
5611:
5608:
5607:
5606:
5603:
5601:
5598:
5594:
5591:
5587:
5584:
5582:
5579:
5577:
5574:
5573:
5572:
5569:
5568:
5567:
5564:
5563:
5561:
5559:
5555:
5551:
5546:
5542:
5538:
5534:
5527:
5522:
5520:
5515:
5513:
5508:
5507:
5504:
5492:
5491:
5487:
5485:
5484:
5480:
5478:
5477:
5473:
5472:
5470:
5466:
5460:
5459:
5455:
5453:
5452:
5448:
5447:
5445:
5441:
5435:
5434:
5430:
5427:
5423:
5422:
5417:
5413:
5409:
5405:
5401:
5398:
5394:
5391:
5390:
5389:
5388:
5384:
5382:
5381:
5377:
5376:
5374:
5370:
5364:
5363:
5359:
5357:
5356:
5352:
5350:
5349:
5345:
5343:
5342:
5338:
5336:
5335:
5331:
5327:
5326:
5322:
5320:
5319:
5315:
5314:
5313:
5310:
5308:
5307:
5303:
5301:
5300:
5296:
5294:
5293:
5289:
5284:
5281:
5280:
5279:
5278:
5274:
5272:
5271:
5267:
5265:
5264:
5260:
5258:
5257:
5253:
5251:
5250:
5246:
5244:
5243:
5239:
5237:
5236:
5232:
5230:
5229:
5225:
5221:
5218:
5216:
5213:
5212:
5211:
5210:
5206:
5202:
5199:
5197:
5194:
5193:
5192:
5191:
5187:
5185:
5184:
5180:
5176:
5173:
5171:
5168:
5167:
5166:
5165:
5161:
5159:
5158:
5154:
5152:
5151:
5147:
5146:
5144:
5140:
5134:
5133:
5129:
5127:
5126:
5122:
5120:
5119:
5115:
5113:
5112:
5108:
5106:
5105:
5101:
5098:
5094:
5090:
5086:
5082:
5079:
5076:
5072:
5068:
5064:
5061:
5058:
5054:
5050:
5046:
5042:
5038:
5034:
5030:
5026:
5022:
5019:
5016:
5012:
5008:
5007:
5003:
5000:
4996:
4992:
4989:
4986:
4982:
4981:
4977:
4975:
4974:
4970:
4968:
4967:
4963:
4960:
4956:
4952:
4948:
4944:
4940:
4936:
4932:
4928:
4925:
4924:
4922:
4918:
4912:
4911:
4907:
4903:
4900:
4899:
4898:
4895:
4891:
4888:
4887:
4886:
4885:
4881:
4877:
4874:
4873:
4872:
4871:
4867:
4865:
4864:
4860:
4857:
4853:
4849:
4848:
4844:
4843:
4841:
4837:
4830:
4826:
4823:
4820:
4816:
4813:
4810:
4806:
4803:
4801:
4800:
4796:
4793:
4789:
4786:
4783:
4779:
4775:
4771:
4770:
4766:
4763:
4759:
4755:
4751:
4750:
4746:
4744:
4743:
4739:
4736:
4732:
4729:
4727:
4726:
4722:
4719:
4715:
4712:
4709:
4705:
4702:
4701:
4699:
4695:
4688:
4684:
4681:
4678:
4674:
4671:
4669:
4668:
4664:
4661:
4657:
4654:
4652:
4651:
4647:
4645:
4644:
4640:
4638:
4637:
4633:
4631:
4630:
4626:
4624:
4623:
4619:
4616:
4612:
4608:
4604:
4600:
4596:
4592:
4591:
4587:
4585:
4584:
4580:
4578:
4577:
4573:
4570:
4566:
4562:
4559:
4556:
4552:
4548:
4545:
4542:
4538:
4534:
4533:
4529:
4526:
4522:
4519:
4518:
4516:
4512:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4447:
4445:
4441:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4411:
4409:
4406:
4401:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4316:
4314:
4310:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4285:
4283:
4279:
4274:
4270:
4266:
4262:
4255:
4250:
4248:
4243:
4241:
4236:
4235:
4232:
4216:
4213:
4211:
4208:
4206:
4203:
4202:
4197:
4194:
4192:
4189:
4188:
4187:
4186:
4182:
4178:
4175:
4174:
4173:
4172:
4167:
4164:
4163:
4161:
4157:
4147:
4141:
4139:
4136:
4135:
4133:
4131:
4126:
4118:
4115:
4113:
4110:
4109:
4108:
4105:
4103:
4097:
4095:
4089:
4087:
4084:
4082:
4079:
4078:
4076:
4074:
4069:
4066:
4064:
4059:
4053:
4050:
4048:
4045:
4041:
4038:
4036:
4033:
4032:
4031:
4025:
4022:
4021:
4016:
4013:
4011:
4008:
4007:
4006:
4000:
3998:
3995:
3993:
3989:
3985:
3984:
3981:
3978:
3976:
3972:
3971:
3969:
3967:
3962:
3956:
3953:
3952:
3950:
3948:
3943:
3940:
3938:
3934:
3928:
3925:
3923:
3920:
3919:
3917:
3915:
3910:
3900:
3897:
3896:
3894:
3891:
3887:
3881:
3878:
3876:
3873:
3871:
3868:
3867:
3865:
3862:
3858:
3852:
3849:
3847:
3844:
3842:
3839:
3838:
3836:
3834:
3829:
3826:
3824:
3819:
3809:
3806:
3804:
3801:
3800:
3798:
3794:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3767:
3765:
3760:
3754:
3751:
3750:
3748:
3746:
3741:
3735:
3732:
3730:
3727:
3725:
3724:HMG-CoA lyase
3722:
3721:
3719:
3717:
3713:
3706:
3703:
3701:
3698:
3697:
3695:
3693:
3688:
3685:
3683:
3679:
3675:
3671:
3667:
3663:
3659:
3655:
3648:
3643:
3641:
3636:
3634:
3629:
3628:
3625:
3618:
3614:
3613:
3608:
3607:
3602:
3599:
3595:
3592:
3591:
3580:
3576:
3572:
3568:
3564:
3560:
3555:
3551:
3547:
3543:
3539:
3535:
3531:
3527:
3523:
3519:
3515:
3510:
3506:
3502:
3498:
3494:
3490:
3486:
3481:
3477:
3473:
3468:
3463:
3459:
3455:
3451:
3446:
3445:
3431:
3427:
3423:
3419:
3414:
3409:
3405:
3401:
3397:
3393:
3389:
3382:
3374:
3370:
3365:
3360:
3356:
3352:
3348:
3344:
3340:
3333:
3326:
3321:
3317:
3312:
3307:
3303:
3299:
3295:
3291:
3287:
3280:
3272:
3266:
3258:
3254:
3249:
3244:
3240:
3236:
3232:
3228:
3224:
3220:
3216:
3209:
3205:
3199:
3191:
3187:
3182:
3177:
3172:
3167:
3163:
3159:
3155:
3148:
3140:
3136:
3131:
3126:
3122:
3118:
3114:
3110:
3106:
3099:
3091:
3087:
3082:
3077:
3072:
3067:
3063:
3059:
3055:
3048:
3040:
3036:
3031:
3026:
3022:
3018:
3014:
3010:
3006:
3002:
2998:
2991:
2989:
2980:
2976:
2972:
2968:
2964:
2960:
2956:
2952:
2944:
2936:
2932:
2927:
2922:
2918:
2914:
2910:
2906:
2902:
2895:
2877:
2873:
2869:
2864:
2859:
2855:
2851:
2847:
2840:
2833:
2825:
2821:
2817:
2813:
2809:
2805:
2797:
2782:
2778:
2772:
2764:
2760:
2755:
2750:
2746:
2742:
2738:
2731:
2723:
2719:
2715:
2711:
2706:
2701:
2697:
2693:
2689:
2682:
2674:
2670:
2665:
2660:
2655:
2650:
2646:
2642:
2638:
2634:
2630:
2623:
2621:
2612:
2608:
2603:
2598:
2594:
2590:
2586:
2579:
2571:
2567:
2562:
2557:
2553:
2549:
2545:
2538:
2530:
2526:
2521:
2516:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2481:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2445:
2438:
2436:
2434:
2425:
2421:
2416:
2411:
2406:
2401:
2397:
2393:
2389:
2382:
2374:
2370:
2365:
2360:
2356:
2352:
2348:
2344:
2340:
2336:
2332:
2325:
2317:
2313:
2308:
2303:
2298:
2293:
2289:
2285:
2281:
2274:
2259:
2255:
2251:
2245:
2237:
2233:
2228:
2223:
2219:
2215:
2211:
2207:
2203:
2196:
2194:
2185:
2181:
2176:
2171:
2167:
2163:
2159:
2155:
2151:
2144:
2142:
2133:
2131:1-4160-2328-3
2127:
2123:
2116:
2114:
2098:
2094:
2090:
2084:
2069:
2065:
2061:
2055:
2053:
2051:
2049:
2040:
2036:
2030:
2022:
2018:
2012:
2005:
2001:
1996:
1994:
1992:
1984:
1980:
1975:
1973:
1971:
1966:
1956:
1953:
1951:
1948:
1947:
1943:
1937:
1932:
1918:
1913:
1910:
1904:
1899:
1896:
1890:
1885:
1882:
1876:
1871:
1868:
1862:
1857:
1856:
1843:
1839:
1835:
1834:
1826:
1823:
1819:
1815:
1813:
1809:
1805:
1801:
1799:
1795:
1792:
1788:
1783:
1781:
1777:
1773:
1768:
1765:
1758:
1743:
1733:
1728:
1726:
1721:
1719:
1715:
1711:
1701:
1699:
1695:
1691:
1687:
1683:
1678:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
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1645:
1641:
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1634:
1630:
1626:
1622:
1612:
1610:
1606:
1602:
1598:
1594:
1590:
1586:
1582:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1540:
1539:steroidogenic
1536:
1527:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1483:
1481:
1477:
1472:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1423:
1421:
1418:
1414:
1410:
1406:
1402:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1342:chromosome 10
1339:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1292:
1287:
1283:
1279:
1276:
1272:
1265:
1263:
1260:
1256:
1252:
1248:
1245:
1241:
1237:
1230:
1228:
1222:
1218:
1215:
1209:
1207:
1201:
1197:
1194:
1190:
1183:
1181:
1175:
1171:
1168:
1162:
1160:
1154:
1150:
1147:
1145:RefSeq (mRNA)
1143:
1136:
1135:
1130:
1126:
1123:
1117:
1116:
1111:
1107:
1104:
1102:
1098:
1091:
1090:
1085:
1081:
1078:
1072:
1071:
1066:
1062:
1059:
1057:
1053:
1046:
1045:
1040:
1036:
1033:
1027:
1026:
1021:
1017:
1014:
1012:
1008:
1005:
1002:
1000:
997:
993:
990:
986:
982:
975:
971:
966:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
921:
919:
916:
915:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
885:
883:
880:
879:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
824:
822:
819:
818:
815:
814:Gene ontology
811:
807:
795:
790:
786:
781:
778:
776:
772:
764:
759:
748:
744:
740:
736:
732:
728:
724:
720:
716:
713:Gonadal ridge
712:
711:
708:
704:
699:
696:
686:
682:
678:
674:
670:
666:
662:
658:
654:
650:
649:
646:
642:
637:
634:
633:
630:
628:
624:
622:
621:
617:
616:
613:
611:
607:
603:
599:
595:
587:
582:
578:
574:
569:
559:
555:
548:
541:
535:
528:
520:
516:
512:
507:
503:
498:
494:
486:
481:
477:
473:
468:
458:
454:
447:
440:
434:
427:
423:
417:
413:
409:
404:
400:
395:
391:
387:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
329:
324:
317:
312:
307:
296:
294:
290:
286:
282:
278:
274:
270:
264:
259:
256:
255:
251:
248:
241:
237:
232:
228:
224:
219:
214:
203:
200:
198:
194:
191:
188:
186:
182:
179:
176:
174:
170:
165:
161:
158:
155:
152:
149:
146:
142:
139:
136:
134:
130:
127:
124:
122:
118:
115:
112:
110:
106:
103:
102:NiceZyme view
100:
98:
94:
91:
88:
86:
82:
79:
76:
74:
70:
65:
60:
56:
53:
50:
48:
44:
41:
38:
36:
32:
27:
22:
19:
6211:Translocases
6208:
6195:
6182:
6169:
6156:
6146:Transferases
6143:
6130:
5987:Binding site
5910:
5735:flavoprotein
5539:, including
5537:dioxygenases
5488:
5481:
5474:
5456:
5449:
5431:
5425:
5419:
5415:
5411:
5407:
5403:
5385:
5378:
5360:
5353:
5346:
5339:
5332:
5323:
5316:
5311:
5304:
5297:
5290:
5275:
5268:
5261:
5254:
5247:
5240:
5233:
5226:
5207:
5188:
5181:
5162:
5155:
5148:
5130:
5123:
5116:
5109:
5102:
5080:
5062:
5020:
5004:
4990:
4978:
4971:
4964:
4926:
4908:
4896:
4882:
4868:
4861:
4845:
4824:
4814:
4804:
4797:
4787:
4767:
4747:
4740:
4730:
4723:
4713:
4703:
4682:
4672:
4665:
4659:
4655:
4648:
4641:
4634:
4627:
4620:
4588:
4581:
4574:
4560:
4546:
4530:
4520:
4183:
4169:
4107:5α-Reductase
4085:
4080:
4063:sex hormones
4023:
3996:
3986:
3973:
3947:pregnenolone
3611:
3605:
3562:
3558:
3520:(1): 42–48.
3517:
3513:
3488:
3484:
3457:
3453:
3395:
3391:
3381:
3346:
3342:
3332:
3323:
3293:
3289:
3279:
3265:
3222:
3218:
3198:
3161:
3157:
3147:
3112:
3108:
3098:
3064:(11): 3555.
3061:
3057:
3047:
3004:
3000:
2954:
2950:
2943:
2908:
2904:
2894:
2883:. Retrieved
2845:
2832:
2807:
2803:
2796:
2785:. Retrieved
2771:
2744:
2740:
2730:
2695:
2691:
2681:
2636:
2632:
2592:
2588:
2578:
2551:
2547:
2537:
2494:
2490:
2480:
2447:
2443:
2395:
2391:
2381:
2338:
2334:
2324:
2287:
2283:
2273:
2262:. Retrieved
2253:
2244:
2209:
2205:
2157:
2153:
2121:
2101:. Retrieved
2092:
2083:
2072:. Retrieved
2063:
2038:
2029:
2020:
2011:
1895:Progesterone
1867:Pregnenolone
1816:
1806:is an older
1804:Ketoconazole
1802:
1789:has been in
1785:Since 2014,
1784:
1769:
1764:nonsteroidal
1760:
1740:
1722:
1707:
1690:testosterone
1679:
1618:
1570:thecal cells
1562:Leydig cells
1533:
1510:inhibitors,
1489:
1475:
1473:
1467:, and other
1436:
1434:
1390:progesterone
1386:pregnenolone
1334:
1322:
1318:
1314:
1310:
1306:
1302:
1301:
1224:
1203:
1177:
1156:
1132:
1113:
1087:
1068:
1042:
1023:
1003:
998:
852:heme binding
721:spermatocyte
667:right testis
663:human kidney
625:
618:
483:102,837,472
470:102,830,531
331:External IDs
266:
90:BRENDA entry
18:
5982:Active site
4261:Cytochromes
4086:17,20-Lyase
3975:aldosterone
3890:Desmosterol
3823:cholesterol
3734:Thiophorase
3716:Ketogenesis
3666:cholesterol
3296:: 136–146.
3109:ChemMedChem
2957:: 114–122.
1818:Seviteronel
1659:oestrogenic
1629:cholesterol
1544:except the
1524:cholesterol
1512:abiraterone
1500:active site
1461:cholesterol
1360:as well as
1331:hydroxylase
1319:17,20-lyase
717:Leydig cell
679:left testis
584:46,661,611
571:46,655,604
309:Identifiers
78:IntEnz view
29:Identifiers
6232:Categories
6185:Isomerases
6159:Hydrolases
6026:Regulation
5867:Tyrosinase
5834:: reduced
5797:: reduced
5765:: reduced
5729:: reduced
5468:CYP701-999
5443:CYP501-699
5372:CYP301-499
5142:CYP101-281
4265:oxygenases
3914:Bile acids
3833:lanosterol
3668:synthesis
3654:Metabolism
2885:2024-02-02
2846:Toxicology
2787:2017-08-30
2264:2016-10-11
2103:2016-10-11
2093:biogps.org
2074:2016-09-27
2006:, May 2017
1985:, May 2017
1961:References
1787:galeterone
1730:See also:
1655:androgenic
1647:1.14.14.32
1640:1.14.14.19
1578:luteinized
1535:Expression
1530:Expression
1516:galeterone
1420:1.14.14.32
1415:activity,
1401:1.14.14.19
1366:progestins
629:(ortholog)
352:HomoloGene
147:structures
114:KEGG entry
58:Alt. names
52:9029-67-8
40:1.14.14.19
6064:EC number
5836:ascorbate
5799:pteridine
5476:CYP704B22
4171:sulfatase
4138:Aromatase
4130:estrogens
4073:androgens
3992:cortisone
3430:199056344
3211:;
3164:(2): 37.
3007:: 29468.
2979:205256638
2911:: 68–75.
2810:: 55–64.
2763:257943362
1791:phase III
1770:The drug
1599:. In the
1508:steroidal
1426:Structure
1392:to add a
1382:estrogens
1378:androgens
1356:) of the
1352:(but not
1227:NP_031835
1206:NP_000093
1180:NM_007809
1159:NM_000102
989:Orthologs
380:EC number
360:GeneCards
67:Databases
6088:Kinetics
6012:Cofactor
5975:Activity
5490:CYP720A1
5458:CYP504B1
5433:CYP318A1
5426:CYP315A1
5421:CYP314A1
5416:CYP307A2
5412:CYP307A1
5408:CYP306A1
5404:CYP302A1
5380:CYP303A1
5355:CYP199A2
5334:CYP176A1
5292:CYP154C3
5256:CYP125A1
5242:CYP119A1
5235:CYP113A1
5183:CYP106A2
5157:CYP102A1
5150:CYP101A1
4920:CYP71-99
4839:CYP51-69
4697:CYP21-49
3988:cortisol
3796:Geranyl-
3579:20595043
3550:23559461
3542:14644808
3422:31367790
3373:32327394
3320:27154414
3257:22266943
3190:29710837
3139:27435344
3090:33158283
3039:27406023
2971:27505042
2951:Steroids
2935:27566228
2876:Archived
2872:27544493
2824:27571716
2781:Archived
2722:44702659
2714:23073980
2611:15687493
2570:27395338
2529:22266943
2464:21095220
2424:25301938
2373:22266943
2316:26719338
2258:Archived
2236:25748612
2184:21092758
2097:Archived
2068:Archived
2002:–
1981:–
1928:See also
1633:steroids
1615:Function
1546:placenta
1465:steroids
1394:hydroxyl
1325:) is an
1275:Wikidata
968:Sources:
893:membrane
733:placenta
462:10q24.32
202:proteins
190:articles
178:articles
151:RCSB PDB
6198:Ligases
5968:Enzymes
5882:1.14.99
5860:: other
5854:1.14.18
5832:1.14.17
5795:1.14.16
5763:1.14.15
5727:1.14.14
5627:1.14.13
5554:1.14.11
5362:CYP255A
5341:CYP183A
5306:CYP161C
5299:CYP158A
5132:CYP99A3
5125:CYP97C1
5118:CYP93E1
5111:CYP90C1
5104:CYP88D6
4973:CYP73A1
4966:CYP72A1
4514:CYP5-20
4196:SULT2A1
4191:SULT1A1
3692:HMG-CoA
3670:enzymes
3662:ketones
3612:CYP17A1
3606:CYP17A1
3522:Bibcode
3505:9888582
3476:8855840
3413:8132106
3364:7415516
3311:5046225
3248:3271139
3227:Bibcode
3181:6027421
3130:5588864
3081:7694247
3030:4942611
3009:Bibcode
2926:5235955
2850:Bibcode
2673:7479852
2641:Bibcode
2520:3271139
2499:Bibcode
2472:5503049
2415:4239641
2364:3271139
2343:Bibcode
2307:4759177
2227:4608367
2175:3047603
2004:Ensembl
1983:Ensembl
1574:ovaries
1572:of the
1564:of the
1556:of the
1542:tissues
1486:Protein
1476:CYP17A1
1437:CYP17A1
1362:gonadal
1335:CYP17A1
1329:of the
1101:UniProt
1056:Ensembl
995:Species
974:QuickGO
749:decidua
604:pattern
364:CYP17A1
323:CYP17A1
316:Aliases
216:CYP17A1
138:profile
121:MetaCyc
47:CAS no.
6172:Lyases
5731:flavin
5610:ALKBH1
5483:CYP710
5451:CYP503
5387:CYP305
5348:CYP197
5312:CYP170
5277:CYP152
5270:CYP147
5263:CYP139
5249:CYP123
5228:CYP111
5209:CYP109
5190:CYP107
5164:CYP105
4403:CYP3 (
3603:Human
3600:(MeSH)
3577:
3548:
3540:
3503:
3474:
3428:
3420:
3410:
3371:
3361:
3318:
3308:
3255:
3245:
3219:Nature
3188:
3178:
3137:
3127:
3088:
3078:
3037:
3027:
2977:
2969:
2933:
2923:
2870:
2822:
2761:
2720:
2712:
2671:
2661:
2609:
2568:
2527:
2517:
2491:Nature
2470:
2462:
2422:
2412:
2371:
2361:
2335:Nature
2314:
2304:
2234:
2224:
2206:Lancet
2182:
2172:
2128:
1673:, and
1609:spleen
1607:, and
1605:thymus
1595:, and
1593:kidney
1568:, the
1566:testes
1560:, the
1469:lipids
1443:. The
1380:, and
1327:enzyme
1261:search
1259:PubMed
1134:P27786
1115:P05093
1011:Entrez
775:BioGPS
340:609300
185:PubMed
167:Search
157:PDBsum
97:ExPASy
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6124:Types
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5635:NADPH
5593:P4HTM
5586:EGLN3
5581:EGLN2
5576:EGLN1
5547:1.14)
5081:CYP81
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5021:CYP79
5006:CYP76
4991:CYP75
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4927:CYP71
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4847:CYP51
4825:CYP46
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4714:CYP22
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4683:CYP20
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4667:CYP18
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4650:CYP16
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4636:CYP14
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4622:CYP12
4590:CYP11
4583:CYP10
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4024:both:
3764:DMAPP
3546:S2CID
3426:S2CID
2975:S2CID
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2842:(PDF)
2759:S2CID
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2718:S2CID
2664:40663
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1441:exons
1413:lyase
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627:Mouse
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5631:NADH
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4576:CYP9
4561:CYP8
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519:Chr.
457:Band
416:Chr.
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289:4NKY
285:4NKX
281:4NKW
277:4NKV
273:3SWZ
269:3RUK
250:RCSB
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197:NCBI
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5748:2D6
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4480:F11
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4434:A43
4429:A37
4354:C19
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4329:A13
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3831:To
3821:To
3762:To
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3690:To
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3530:doi
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3359:PMC
3351:doi
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3243:PMC
3235:doi
3223:482
3204:PDB
3176:PMC
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3125:PMC
3117:doi
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3066:doi
3025:PMC
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2959:doi
2955:115
2921:PMC
2913:doi
2909:441
2858:doi
2812:doi
2808:179
2749:doi
2700:doi
2696:242
2659:PMC
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2597:doi
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2359:PMC
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2302:PMC
2292:doi
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2222:PMC
2214:doi
2210:385
2170:PMC
2162:doi
2158:125
1665:to
1583:in
1522:or
1492:kDa
1422:).
1340:on
745:lip
580:End
479:End
368:OMA
344:MGI
240:PDB
173:PMC
145:PDB
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4852:A1
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4782:C1
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4687:A1
4677:A1
4660:A1
4615:C1
4613:,
4611:B3
4609:,
4607:B2
4605:,
4603:B1
4601:,
4599:A2
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4595:A1
4569:B1
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4565:A1
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4541:M2
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4537:G1
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4389:U1
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