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pituitary gland research at
National Taiwan University with the support from China Foundation for the Promotion of Education and Culture. At that time, the academic community only knew that protein research was developing rapidly abroad and a scholar had already made extraordinary achievements, and so when Dr. Li introduced the first-hand knowledge, it really attracted and inspired domestic scientists. Dr. Li believed that the protein chemistry was the foundation of future biochemical and biological sciences research, so he decided to assist the establishment of domestic protein research institute. In order to cultivate talents in Taiwan, Dr. Li personally provided scholarships and selected and persuaded scholars who have settled in Taiwan to continue the research in his or other research institutes. With the support from Academia Sinica, National Science Council, Ministry of Education, and National Taiwan University, Institute of Biological Chemistry and Institute of Biochemical Sciences, College of Life Science, National Taiwan University were established in 1972. The two institutes were originally located in the National Taiwan University's campus (Institutes of Biological Chemistry moved to Academia Sinica's campus later) to integrate research institutes and the University. Dr. Li had always been serving the chief consultant to assist the collaboration of the two institutes and international networking. The achievement of the two institutes today are built on Dr. Li's hard work. Dr. Li's foresight also brought about the domestic development of biotechnology and genetic engineering.
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research had direct impact on clinical applications, especially in growth and fertility. It is estimated that he had published more than 1,000 research papers and had collaborated with more than 300 people. In addition, he was also the recipient of a lot of honors (more than 25). The most significant ones are as follows:
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Despite his significant scientific achievements, Dr. Li was also dedicated to the initiation and development of protein research in Taiwan. In spring 1958, Dr. Li was invited by Dr. Shih Hu to lecture a three-week course regarding the newly developed technology in protein chemistry and his latest
391:
Li was an expert in diversified areas, including endocrinology, biochemistry, and peptide synthesis. He not only was a widely recognized leader in pituitary-secreted research for his contribution in hormone and growth factors, but also greatly advanced the field of protein chemistry. All of his
46:
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Eight of the nine hormones secreted by the anterior pituitary were isolated and identified by Li and his research team. These nine hormones can be divided into three groups based on the similarity of their chemical properties and biological activities.
1112:"Classic pages in Obstetrics and Gynecology. Interstitial cell stimulating hormone. II. Method of preparation and some physico-chemical studies, by Choh Hao Li, Miriam E. Simpson, and Herbert M. Evans. Endocrinology, vol. 27, pp. 803-808, 1940",
256:
and later joined the staff. He became professor in 1950. He served as
Director of the Hormone Research Laboratory at Berkeley from 1950 to 1967 and at UCSF from 1967 until his retirement in 1983. In 1955, he was elected as Academician of
276:. In 1956, Li and his group showed that ACTH consists of 39 amino acids arranged in a specific order, and that the whole chain of the natural hormone is not necessary for its action. He isolated another pituitary hormone called
1303:
296:. The whole process included grinding thousands of glands, extracting the hormone, and then identifying its chemistry and biology at the molecular level. This was a breakthrough in biological studies.
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Ingle, D J; Nezamis, J E; Moreley, E H; Li, C H (1953), "The effect of some partially purified preparations of corticotrophin upon the work performance of adrenalectomized-hypophysectomized rats",
280:(MSH) and found that not only does this hormone produce some effects similar to those produced by ACTH, but also that part of the amino acid chain of MSH is the same as that of ACTH.
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1944 - Li was the first person to isolate growth hormone from cow brains. The lack of function of cow growth hormone on human body motivated Dr. Li to find human growth hormone.
264:
Li spent his entire academic career studying the pituitary-gland hormones. In collaboration with various co-workers, he isolated several protein hormones, including
1223:
580:
Li CH, Geschwind II, Levy AL, Harris JI, Dixon JS, Pon NG, Porath JO (1954). "Isolation and properties of alpha-corticotropin from sheep pituitary glands".
1298:
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Li, C.H.; Simpson, M. E.; Evans, H. M. (1940). "Interstitial cell stimulating hormone. II. Method of preparation and some physico-chemical studies".
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Geschwind II, Li CH, Barnafi L (1956). "Isolation and structure of melanocyte-stimulating hormone from porcine pituitary glands".
495:
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Li, C H; Geschwind, I I; Cole, R D; Raacke, I D; Harris, J I; Dixon, J S (1955). "Amino-acid sequence of alpha-corticotropin".
1308:
548:
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Li CH, Barnafi L, Chrétien M, Chung D (1965). "Isolation and amino-acid sequence of β-LPH from sheep pituitary glands".
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Li, C H; Dixon, J S; Lo, T B; Pankov, Y A; Schmidt, K D (1969). "Amino-acid sequence of ovine lactogenic hormone".
501:
308:
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Li, C. H. (1956). "Hormones of the
Anterior Pituitary Gland. Part I. Growth and Adrenocorticotropic Hormones".
277:
218:; April 21, 1913 – November 28, 1987) was a Chinese-born American biochemist who discovered in 1966 that human
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in 1976 and synthesized it to study its biological activity after they defined the structure of β-endorphin.
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1964 - Li and his research team discovered and isolated lipotropin, and its structure was defined in 1965.
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Hruby, Victor J.; Yamashiro, Donald (1988), "Memorial issue in honor of
Professor Choh Hao Li. Part I",
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1956 - Li successfully isolated human and monkey growth hormone and demonstrated its efficacy to treat
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850:"Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands"
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R. David Cole, "Choh Hao Li", Biographical
Memoirs of the National Academy of Sciences (1996)
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Hormones of the anterior pituitary gland. I. Growth and adrenocorticotropic hormones
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There are more than ten colleges of this name: it's not clear which one is meant.
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252:. In 1935, he immigrated to the US, where he took up postgraduate studies at the
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Hruby, V J (1988), "In memoriam Choh Hao Li, April 21, 1913-November 28, 1987",
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There are several universities of this name: it's not clear which one is meant.
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10.1002/1097-0142(195707/08)10:4<698::AID-CNCR2820100409>3.0.CO;2-Z
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Register of the Choh Hao Li Papers, 1937-1987, Online
Archive of California
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University of
California, Berkeley College of Letters and Science faculty
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Li, H; Evans, H. M. (1944). "The isolation of pituitary growth hormone".
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the
Nicholas Andry Award from the Association of Bone and Joint Surgeons
1116:, vol. 17, no. 5 (published Nov 1, 1973), p. 716, 1973,
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The
Establishment of Institute of Biological Chemistry, Academia Sinica
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1971 - (the year the synthesis of Human Growth
Hormone was announced)
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1969 - Li discovered the complete primary structure of sheep prolactin.
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Cole, R D (1996), "Choh Hao Li: April 21, 1913 - November 28, 1987",
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the Scientific Achievement Award from American Medical Association
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1100:, vol. 31, no. 3 (published Mar 1988), pp. 253–4,
740:. Advances in Protein Chemistry. Vol. 11. pp. 101–190.
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Recipients of the Albert Lasker Award for Basic Medical Research
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Institute of Biochemical Sciences, National Taiwan University
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1953 - Li was the first person to isolate and extract ACTH.
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Forgotten Superheroes of Science and Medicine: Choh Hao Li
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Biographical Memoirs of the National Academy of Sciences
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1971 - the National Award of the American Cancer Society
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the Amory Prize of American Academy of Arts and Sciences
952:"Growth hormone from monkey and human pituitary glands"
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the Lewis Price of the American Philosophical Society
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1984 - Foreign Member of Indian Institute of Science
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1978 - Foreign Member of Chilean Academy of Sciences
1198:Li, Choh Hao, Social Networks and Archival Context
1183:Institute of Biological Chemistry, Academia Sinica
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353:1974 - Li and his team sequenced human LH and TSH.
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1132:, vol. 9, no. 1, pp. 41–2, 1969,
1130:Triangle; the Sandoz Journal of Medical Science
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413:Albert Lasker Award for Basic Medical Research
147:Albert Lasker Award for Basic Medical Research
402:1951 - the Award of American Chemical Society
357:The third group includes growth hormone and
459:Li was elected to the following academies:
378:1970 - Li synthesized proteins with human
283:
44:
1299:University of California, Berkeley alumni
967:
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883:
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398:the Ciba Award from the Endocrine Society
333:in camel brain. The team isolated human
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447:the Koch Award of the Endocrine Society
123:Discovering and synthesizing the human
16:Chinese-American biochemist (1913–1987)
1269:Chinese emigrants to the United States
1236:
575:
573:
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451:1987 - the Alan E. Pierce Award (now
288:In 1940, Li successfully purified the
1095:
471:American Academy of Arts and Sciences
345:(FSH), luteinizing hormone (LH), and
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570:
475:1973 - Member of the United States
13:
1082:10.1111/j.1399-3011.1988.tb01371.x
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254:University of California, Berkeley
114:University of California, Berkeley
14:
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1314:20th-century American biochemists
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1060:, vol. 70, pp. 221–39,
442:of the American Chemical Society
1254:20th-century Chinese biologists
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549:Medical College of Pennsylvania
502:Chinese University of Hong Kong
455:) from American Peptide Society
309:melanocyte-stimulating hormones
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278:melanocyte-stimulating hormone
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1:
746:10.1016/S0065-3233(08)60421-0
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272:to increase its secretion of
268:(ACTH), which stimulates the
230:) consists of a chain of 256
1309:University of Nanking alumni
496:Catholic University of Chile
477:National Academy of Sciences
343:follicle stimulating hormone
7:
929:10.1126/science.99.2566.183
531:University of San Francisco
347:thyroid stimulating hormone
305:adrenocorticotropic hormone
266:adrenocorticotropic hormone
92:, California, United States
10:
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1289:People from Panyu District
1279:Members of Academia Sinica
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854:Proc. Natl. Acad. Sci. USA
341:The second group includes
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1284:Nanjing University alumni
1264:Biologists from Guangdong
1219:History of UCSF biography
1098:Int. J. Pept. Protein Res
1074:Int. J. Pept. Protein Res
509:University of the Pacific
453:R. Bruce Merrifield Award
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303:The first group includes
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1274:Educators from Guangdong
1209:Biography and chronology
440:William H. Nichols Medal
183:University of California
154:William H. Nichols Medal
848:Li CH, Chung D (1976).
284:Scientific achievements
1162:10.1530/acta.0.0140093
1114:Am. J. Obstet. Gynecol
875:10.1073/pnas.73.4.1145
543:University of Colorado
537:Long Island University
463:1958 - Academician of
723:10.1210/endo-27-5-803
524:University of Uppsala
517:Saint Peter's College
469:1963 - Member of the
325:1975 - Li discovered
261:, Republic of China.
513:Marquette University
329:when trying to find
248:and educated at the
138:Shen-hwai Lu (Annie)
1259:American biologists
1005:1969Natur.224..695L
921:1944Sci....99..183H
866:1976PNAS...73.1145L
811:1965Natur.208.1093H
805:(5015): 1093–1094.
696:10.1021/ja01598a085
645:1955Natur.176..687L
594:1954Natur.173..251L
489:10 Honorary Degrees
290:luteinizing hormone
1203:Choh Hao Li Papers
950:Li, C. H. (1957).
684:J. Amer. Chem. Soc
250:Nanjing University
110:Nanjing University
915:(2566): 183–184.
819:10.1038/2081093b0
690:(17): 4494–4495.
639:(4484): 687–689.
588:(4397): 251–253.
411:1962 - the first
241:up to that time.
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164:Scientific career
82:November 28, 1987
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180:Institutions
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84:(1987-11-28)
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21:Chinese name
1249:1987 deaths
1244:1913 births
438:1979 - the
335:β-endorphin
327:β-endorphin
311:(MSH), and
292:from sheep
239:synthesized
232:amino acids
196:(sometimes
194:Choh Hao Li
98:Nationality
38:Choh Hao Li
25:family name
1238:Categories
564:References
313:lipotropin
274:corticoids
215:Lǐ Zhuōhào
198:Cho Hao Li
174:Biochemist
59:1913-04-21
1138:0041-2597
782:ignored (
772:cite book
382:activity.
372:children.
359:prolactin
246:Guangzhou
220:pituitary
125:pituitary
71:Guangdong
67:Guangzhou
1170:13113828
1066:11619324
978:13472604
937:17736901
835:27984837
764:13469637
661:13265807
618:31750203
610:13144736
526:, Sweden
500:1970 -
432:1977 -
426:1972 -
307:(ACTH),
236:molecule
101:American
90:Berkeley
19:In this
1146:4896971
1122:4599575
1106:3286549
1090:3073145
1050:Sources
1021:4255758
1001:Bibcode
917:Bibcode
909:Science
894:1063395
862:Bibcode
827:4162144
807:Bibcode
669:4264995
641:Bibcode
590:Bibcode
547:1982 -
541:1981 -
535:1979 -
529:1978 -
522:1977 -
494:1962 -
445:1981 -
417:1970 -
405:1955 -
396:1947 -
349:(TSH).
224:hormone
222:growth
202:Chinese
129:hormone
127:growth
73:, China
1168:
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993:Nature
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956:Cancer
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