166:
type 1, African horse sickness virus, rabbit hemorrhagic disease virus, herpes simplex virus, hepatitis C virus, bluetongue virus, pseudorabies virus, and diseases such as malaria, HIV, and tuberculosis were developed using engineered poxvirus vectors. While many vaccines are in preclinical or clinical development, six have been licensed for veterinary use.
184:
Paoletti received numerous awards including: New York State
Regents Scholarship, the National Institutes of Health Predoctoral Traineeship, the New York State Department of Health Predoctoral Fellowship, National Institutes of Health Postdoctoral Fellowship, Il Leone Di San Marco Award for Science
165:
Vaccines against several pathogens including avian influenza virus, Newcastle disease virus, cytomegalovirus, canine distemper virus, feline leukemia virus, feline immunodeficiency virus, equine influenza virus, equine herpes virus, Japanese encephalitis virus, human T cell leukemia/lymphoma virus
146:
as a senior research scientist. Four seminal papers, all published in the
Proceedings of the National Academy of Sciences with Dennis Panicali and others provided the technology and proof of principle to construct live vaccines using genetically engineered
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A prime-dose regimen with canarypox ALVAC-HIV (vCP1521) vaccine and HIV-1 gp120 AIDSVAX B/E was found to be safe, well tolerated and 31.2% effective for the prevention of HIV acquisition in HIV-uninfected adults in
Thailand.
499:"Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D"
78:
who developed the technology to express foreign antigens in vaccinia and other poxviruses. This advance led to the development of vaccines against multiple disease-causing pathogens.
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to commercialize vectored vaccines. Over the years, highly attenuated poxvirus vectors (NYVAC, ALVAC and TROVAC) that induced cell-mediated and humoral responses were developed.
176:
This highly-adaptable viral vectored vaccine platform has been adopted by researchers to prevent infection against many pathogens, including the pandemic-causing SARS-CoV-2
440:"Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin"
102:
at
Buffalo, Roswell Park Division in 1971. Early in his graduate studies, Paoletti co-authored a paper that described, for the first time, RNA polymerase activity in
674:"Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria"
123:
381:"Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus"
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151:. In 1990 Paoletti's laboratory was the first to sequence the genome of vaccinia virus, an achievement gained without the use of high-throughput
771:"Safety and reactogenicity of canarypox ALVAC-HIV (vCP1521) and HIV-1 gp120 AIDSVAX B/E vaccination in an efficacy trial in Thailand"
591:
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Goebel SJ, Johnson GP, Perkus ME, Davis SW, Winslow JP, Paoletti E (November 1990). "The complete DNA sequence of vaccinia virus".
219:. He held adjunct professorships at SUNY-Albany, Rensselaer Polytechnic Institute and Albany Medical College of Union University.
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Paoletti E, Taylor J, Meignier B, Meric C, Tartaglia J (1995). "Highly attenuated poxvirus vectors: NYVAC, ALVAC and TROVAC".
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In 1981, Paoletti founded and was the
Founding Scientist of Virogenetics Corporation, a private, for-profit company based in
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Pitisuttithum P, Rerks-Ngarm S, Bussaratid V, Dhitavat J, Maekanantawat W, Pungpak S, et al. (2011).
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Sánchez-Sampedro L, Perdiguero B, MejĂas-PĂ©rez E, GarcĂa-Arriaza J, Di Pilato M, Esteban M (April 2015).
90:
on May 22, 1943. He emigrated with his family to New York in 1951. Paoletti received B.A. degree from
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Paoletti E, Tartaglia J, Taylor J (1994). "Safe and effective poxvirus vectors--NYVAC and ALVAC".
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article on
Paoletti's announcement of the discovery of vaccinia vectored vaccines (1983)
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Ockenhouse CF, Sun PF, Lanar DE, Wellde BT, Hall BT, Kester K, et al. (June 1998).
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delivered in 1975. Paoletti's postdoctoral years were spent in the laboratory of Dr.
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Poxvirus vectors have also been used to develop vaccines against specific cancers.
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In 1974, Paoletti joined the
Wadsworth Center for Laboratories and Research at the
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Gebre MS, Brito LA, Tostanoski LH, Edwards DK, Carfi A, Barouch DH (March 2021).
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Proceedings of the
National Academy of Sciences of the United States of America
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Proceedings of the
National Academy of Sciences of the United States of America
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Proceedings of the
National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Paoletti also served as on the editorial board of several journals including
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Paoletti E, Lipinskas BR, Samsonoff C, Mercer S, Panicali D (January 1984).
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322:"Molecular genetics of vaccinia virus: demonstration of marker rescue"
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296:"David Baltimore - Nobel Lecture: Viruses, Polymerases and Cancer"
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Big Shot: Passion, Politics, and the Struggle for an AIDS Vaccine
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and the International Association of Biological Standardization.
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Panicali D, Davis SW, Weinberg RL, Paoletti E (September 1983).
238:"RNA polymerase activity in purified infectious vaccinia virus"
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brief on Virogenetics and Institut Merieux partnership (1990)
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He was affiliated with several scientific societies namely:
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New York Times article on Vaccinia-vectored vaccines (1988)
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Enzo Paoletti was born in Monti di Villa, Bagni di Lucca,
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National Institute of Allergy and Infectious Diseases
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article on Paoletti's vaccine against herpes (1983)
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American Association for the Advancement of Science
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185:(1984) and Rhone- Poulenc Prix Innovation (1991).
592:"New York State Weighs Venture to Market Vaccine"
202:American Society of Tropical Medicine and Hygiene
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236:Munyon W, Paoletti E, Grace JT (December 1967).
320:Nakano E, Panicali D, Paoletti E (March 1982).
936:article on Vaccinia vectored vaccines (1985)
37:Monti di Villa, Bagni di Lucca, Lucca, Italy
928:article on new vaccine developments (1984)
830:"Novel approaches for vaccine development"
647:Developments in Biological Standardization
620:Developments in Biological Standardization
891:Google Scholar of Paoletti's publications
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71:(May 22, 1943 – January 17, 2018) was an
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379:Panicali D, Paoletti E (August 1982).
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200:, New York State Academy of Science,
720:"The evolution of poxvirus vaccines"
126:, Laboratory of Biology of Viruses,
969:, Lucca Edition, (January 23, 2018)
911:Wallis, Claudia (October 31, 1983).
880:Google Patent of Paoletti's patents
140:New York State Department of Health
98:in 1966 and he earned a Ph.D. from
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913:"Medicine: Made-to-Order Vaccines"
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678:The Journal of Infectious Diseases
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190:American Society for Microbiology
180:Awards and academic affiliations
134:Career and research achievements
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956:Review by Patricia Thomas of
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194:American Society for Virology
120:National Institutes of Health
106:- a key finding noted by Dr.
796:10.1371/journal.pone.0027837
570:10.1016/0042-6822(90)90294-2
100:State University of New York
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965:Tribute to Dr. Paoletti in
16:Italian-American virologist
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926:New York Times Magazine
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406:10.1073/pnas.79.16.4927
934:Science and Technology
347:10.1073/pnas.79.5.1593
263:10.1073/pnas.58.6.2280
564:(1): 247–66, 517–63.
524:10.1073/pnas.81.1.193
1002:American scientists
997:Italian virologists
787:2011PLoSO...627837P
515:1984PNAS...81..193P
456:1983PNAS...80.5364P
397:1982PNAS...79.4927P
338:1982PNAS...79.1593N
254:1967PNAS...58.2280M
210:Journal of Virology
1007:American inventors
597:The New York Times
300:www.nobelprize.org
128:Bethesda, Maryland
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981:Categories
967:Il Tirreno
223:References
149:poxviruses
76:virologist
62:Virologist
59:Occupation
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82:Education
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603:April 9,
558:Virology
216:Virology
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724:Viruses
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31:Born
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