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168:). This is present in almost all strains from the Far East but only 20% of European isolates. The antigen was discovered in 1993 and is encoded by a 456-base gene. The protein has 151 amino acids, with a signal sequence of 20 amino acids. The mitogenic antigens are scattered across the protein but two
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content of this gene is 35%—lower than the genomic average (47%) suggesting that this gene has been acquired from some other organism. The organism from which this gene originated has not yet been identified. This gene seems likely to have been introduced into the genome by a
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Yoshino K, Ramamurthy T, Nair GB, Fukushima H, Ohtomo Y, Takeda N, Kaneko S, Takeda T (1995) Geographical heterogeneity between Far East and Europe in prevalence of the ypm gene encoding the novel superantigen among
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Fukushima H Matsuda Y, Seki R, Tsubokura M, Takeda N, Shubin FN, Paik IK, Zheng XB (2001) Geographical heterogeneity between Far
Eastern and Western countries in prevalence of the virulence plasmid, the superantigen
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Zalmover IIu, Znamenskiĭ VA, Ignatovich VO, Vishniakov AK, Serov GD (1969) Clinical aspects of Far
Eastern scarlatina-like fever. Voen Med Zh 1:47–51
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Antonov VS (1978) Differential diagnosis of scarlet fever-like forms of pseudotuberculosis and scarlet fever in children. Pediatriia 52(1):6–9
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occasionally occurs; it primarily occurs in patients with preexisting comorbidities such as diabetes mellitus, liver cirrhosis, or
184:, given the nearby presence of a phage integration site, but the mechanism of entry into the genome is not currently known.
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The clinical features of this disease appear to be due—at least in part—to the production of a superantigen—YpM (
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has been divided into 6 genetic groups: group 1 has only been isolated from the Far East.
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Solozhenkin VG (1978) Scarlet fever-like disease in children. Pediatriia (1):27–28
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residues (residues 32 and 129) which form a disulfide bridge are critical.
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failure rarely occurs. Relapses occur in up to 50% of patients.
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121:. Postinfective complications include reactive arthritis,
315:-derived mitogen, and the high-pathogenicity island among
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The first outbreak of this disease was reported from the
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red skin rash usually of the face, elbows, and knees
279:infection in children, resembling Izumi fever and
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336:strains. J Clin Microbiol 33(12) 3356–3358
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51:is an infectious disease caused by the
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197:The main differential diagnosis is
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147:serotype O1. 95% are subtype O1b.
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283:. Pediatr Infect Dis 2: 123–126
275:Sato K, Ouchi K, Taki M (1983)
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141:The cause of this disease is
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334:Yersinia pseudotuberculosis
317:Yersinia pseudotuberculosis
313:Yersinia pseudotuberculosis
277:Yersinia pseudotuberculosis
164:Yersinia pseudotuberculosis
151:Yersinia pseudotuberculosis
144:Yersinia pseudotuberculosis
60:Yersinia pseudotuberculosis
49:Far East scarlet-like fever
22:Far East scarlet-like fever
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99:mesenteric lymphadenitis
63:. In Japan it is called
113:is common in children.
97:Other features include
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193:Differential diagnosis
92:toxic shock syndrome
361:Bacterial diseases
131:glomerulonephritis
71:Signs and symptoms
42:Infectious disease
31:Scarlatinoid fever
281:Kawasaki syndrome
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82:skin desquamation
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16:Medical condition
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223:You can help by
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166:-derived mitogen
123:erythema nodosum
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157:Pathophysiology
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65:Izumi fever
27:Other names
355:Categories
264:References
88:red tongue
205:Treatment
188:Diagnosis
103:arthritis
85:exanthema
38:Specialty
170:cysteine
56:bacillus
250:Pacific
244:History
258:Russia
129:, and
127:iritis
115:Sepsis
107:Kidney
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137:Cause
175:The
101:and
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177:G+C
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