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or immunosuppressants is the main method for deliberately inducing immunosuppression; in optimal circumstances, immunosuppressive drugs primarily target hyperactive components of the immune system. People in remission from cancer who require immunosuppression are not more likely to experience a
255:, resulting in the death of the donated tissue. Immunosuppressants are administered in order to help prevent rejection; however, the body becomes more vulnerable to infections and malignancy during the course of such treatment.
93:. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.
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between the donor and recipient. As a result, the immune system detects the new tissue as "foreign", and attempts to remove it by attacking it with
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Shelton, Edward; Laharie, David; Scott, Frank I.; Mamtani, Ronac; Lewis, James D.; Colombel, Jean-Frederic; Ananthakrishnan, Ashwin N. (July 2016).
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Steroids were the first class of immunosuppressant drugs identified, though side-effects of early compounds limited their use. The more specific
560:"Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis"
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deficiency are immune impairment that individuals are born with or are acquired, which in turn can lead to immunodeficiency problems.
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has been used to decrease the strength of the immune system. Dr. Joseph Murray of
Brigham and Women's Hospital was given the
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in general includes both beneficial and potential adverse effects of decreasing the function of the immune system.
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showing an opportunistic infection due to immunosuppression - large (blue) cell below-center-left infected with a
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In general, deliberately induced immunosuppression is performed to prevent the body from
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Charles A Janeway, Jr; Travers, Paul; Walport, Mark; Shlomchik, Mark J. (2001).
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in 1980 (together with azathioprine) that allowed significant expansion of
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Ladwig, Gail B.; Ackley, Betty J.; Makic, Mary Beth Flynn (2016-03-15).
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Immunodeficiency is also a potential adverse effect of many
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Non-deliberate immunosuppression can occur in, for example,
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743:"Transplant rejection: MedlinePlus Medical Encyclopedia"
895:"Immunodeficiency (Primary and Secondary). Information"
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Clinical
Journal of the American Society of Nephrology
803:"Responses to alloantigens and transplant rejection"
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was identified in 1960, but it was the discovery of
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Immunosuppressive drugs have the potential to cause
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924:. Lippincott Williams & Wilkins. p. 408.
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442:"Immunosuppression: Overview, History, Drugs"
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610:Mosby's Guide to Nursing Diagnosis - E-Book
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241:heart transplantation
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162:Further information:
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519:10.2215/CJN.08570814
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805:. Garland Science.
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