206:
2013:
29:
511:
Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). "A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa
Lentinan
624:
Isoda N, Eguchi Y, Nukaya H, Hosho K, Suga Y, Suga T, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma".
597:
Kataoka H, Shimura T, Mizoshita T, Kubota E, Mori Y, Mizushima T, et al. (2009). "Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life".
651:
Shimizu K, Watanabe S, Watanabe S, Matsuda K, Suga T, Nakazawa S, Shiratori K (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer".
678:
539:
Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). "Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer".
59:
970:
234:
889:
41:
808:
404:
Ng ML, Yap AT (October 2002). "Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)".
381:
364:
1277:
568:"Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer"
305:. Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously. The authors of an
707:
854:
985:
319:
Lentinan has been the subject of a limited number of clinical studies in cancer patients in Japan; however, evidence of
241:
1203:
1232:
801:
332:
125:
1270:
185:
703:
282:
with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (NaOH).
2037:
1100:
846:
794:
365:"Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line"
488:
Nimura H, Mitsumori N, Takahashi N, Kashimura H, Takayama S, Kashiwagi H, Yanaga K (June 2006). "".
201:
2042:
1337:
1830:
965:
441:"Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC"
2016:
1824:
1263:
859:
311:
study of lentinan suggested that the compound may be active when administered orally in mice.
174:
1818:
1142:
961:
952:
301:
experiment showed lentinan stimulated production of white blood cells in the human cell line
1957:
975:
134:
98:
8:
1095:
980:
344:
89:
205:
1198:
1176:
1154:
1009:
1004:
957:
948:
753:
741:
470:
566:
Hazama S, Watanabe S, Ohashi M, Yagi M, Suzuki M, Matsuda K, et al. (July 2009).
745:
660:
633:
606:
579:
548:
521:
493:
462:
421:
386:
567:
474:
51:
1410:
1237:
1222:
1016:
906:
757:
737:
452:
413:
376:
72:
1859:
1805:
1785:
1676:
998:
942:
873:
817:
1846:
1643:
1400:
1377:
1357:
1059:
417:
255:
1186:
457:
440:
2031:
1952:
1869:
1757:
1648:
1034:
937:
877:
864:
780:
1836:
1717:
1699:
1347:
1287:
1242:
1210:
1171:
1064:
899:
894:
821:
664:
637:
610:
583:
552:
525:
497:
466:
425:
390:
67:
773:
749:
382:
10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O
1994:
1982:
1854:
1765:
1513:
1508:
1448:
1255:
1181:
1166:
1130:
1026:
882:
786:
279:
20:
1770:
1712:
1707:
1580:
1533:
1159:
1147:
1079:
1069:
1039:
923:
869:
302:
259:
222:
109:
1928:
1924:
1879:
1793:
1775:
1742:
1727:
1548:
1471:
1433:
1215:
1110:
1105:
1074:
45:
1945:
1906:
1891:
1813:
1747:
1620:
1615:
1600:
1585:
1501:
1496:
1316:
1311:
1191:
911:
837:
728:
Nakamura T (August 1992). "Shiitake (Lentinus edodes) dermatitis".
320:
297:
263:
154:
1987:
1967:
1935:
1910:
1900:
1896:
1874:
1737:
1732:
1722:
1632:
1595:
1590:
1568:
1553:
1543:
1460:
1438:
1422:
1227:
487:
307:
1977:
1972:
1962:
1939:
1916:
1884:
1671:
1666:
1610:
1573:
1558:
1538:
1525:
1486:
1481:
1476:
1389:
1342:
1332:
1306:
1301:
650:
1563:
1366:
682:
596:
510:
165:
190:
145:
28:
565:
538:
623:
779:Memorial Sloan-Kettering Cancer Center's page for
438:
406:Journal of Alternative and Complementary Medicine
2029:
439:Yang P, Liang M, Zhang Y, Shen B (August 2008).
97:
504:
490:Gan to Kagaku Ryoho. Cancer & Chemotherapy
481:
432:
397:
356:
1271:
802:
644:
617:
590:
559:
532:
362:
1285:
1278:
1264:
816:
809:
795:
204:
456:
380:
133:
727:
721:
492:(in Japanese). 33 Suppl 1 (1): 106–109.
314:
200:
2030:
708:Memorial Sloan Kettering Cancer Center
290:
1259:
790:
696:
671:
403:
173:
50:
331:Lentinan has been reported to cause
71:
153:
13:
742:10.1111/j.1600-0536.1992.tb05211.x
363:Sia GM, Candlish JK (March 1999).
326:
14:
2054:
767:
2012:
2011:
27:
1204:Polyinosinic:polycytidylic acid
776:effects (antitumor and others)
1:
350:
333:shiitake mushroom dermatitis
273:
7:
338:
285:
10:
2059:
847:Colony-stimulating factors
418:10.1089/107555302320825093
217:Chemical and physical data
2007:
1845:
1802:
1784:
1756:
1698:
1691:
1659:
1631:
1524:
1459:
1421:
1388:
1365:
1356:
1325:
1294:
1123:
1101:Histamine dihydrochloride
1088:
1052:
1025:
922:
845:
836:
829:
458:10.1007/s12325-008-0079-x
231:
221:
216:
184:
164:
144:
124:
108:
88:
83:
58:
40:
35:
26:
1338:Cyclohexane conformation
1233:Bacillus Calmette–Guérin
52:International Drug Names
1831:Isomaltooligosaccharide
1053:Other protein / peptide
966:Ropeginterferon alfa-2b
653:Hepato-Gastroenterology
626:Hepato-Gastroenterology
599:Hepato-Gastroenterology
514:Hepato-Gastroenterology
1825:Galactooligosaccharide
860:Efbemalenograstim alfa
1819:Fructooligosaccharide
1143:heterocyclic compound
962:Peginterferon alfa-2b
953:Peginterferon alfa-2a
369:Phytotherapy Research
315:Human clinical trials
976:Interferon alfacon-1
278:Lentinan is a β-1,3
1096:Female sex steroids
981:Interferon alpha-n3
572:Anticancer Research
541:Anticancer Research
445:Advances in Therapy
345:Medicinal mushrooms
291:Preclinical studies
23:
1199:polyribonucleotide
1177:Glatiramer acetate
1010:Interferon beta 1b
1005:Interferon beta 1a
971:Interferon alfa n1
958:Interferon alfa 2b
949:Interferon alfa 2a
730:Contact Dermatitis
258:isolated from the
19:
2025:
2024:
2003:
2002:
1687:
1686:
1253:
1252:
1119:
1118:
1048:
1047:
520:(28): 2662–2668.
512:Research Group".
249:
248:
186:CompTox Dashboard
16:Chemical compound
2050:
2038:Immunostimulants
2015:
2014:
1806:oligosaccharides
1786:Tetrasaccharides
1696:
1695:
1411:Dihydroxyacetone
1363:
1362:
1280:
1273:
1266:
1257:
1256:
1238:Melanoma vaccine
1223:Inosine pranobex
1155:hydroxyquinoline
1017:Interferon gamma
843:
842:
834:
833:
818:Immunostimulants
811:
804:
797:
788:
787:
762:
761:
725:
719:
718:
716:
714:
700:
694:
693:
691:
689:
675:
669:
668:
648:
642:
641:
621:
615:
614:
594:
588:
587:
578:(7): 2611–2617.
563:
557:
556:
547:(7): 2739–2745.
536:
530:
529:
508:
502:
501:
485:
479:
478:
460:
436:
430:
429:
401:
395:
394:
384:
360:
268:Lentinula edodes
245:
244:
237:
209:
208:
194:
192:
177:
157:
137:
101:
75:
54:
31:
24:
22:
18:
2058:
2057:
2053:
2052:
2051:
2049:
2048:
2047:
2043:Polysaccharides
2028:
2027:
2026:
2021:
1999:
1860:Oat beta-glucan
1847:Polysaccharides
1841:
1804:
1798:
1780:
1752:
1683:
1677:Neuraminic acid
1655:
1627:
1520:
1455:
1417:
1384:
1358:Monosaccharides
1352:
1321:
1290:
1284:
1254:
1249:
1115:
1084:
1044:
1021:
999:Interferon beta
943:Interferon alfa
918:
874:Lipegfilgrastim
825:
815:
770:
765:
726:
722:
712:
710:
702:
701:
697:
687:
685:
677:
676:
672:
659:(89): 240–244.
649:
645:
632:(90): 437–441.
622:
618:
605:(90): 547–550.
595:
591:
564:
560:
537:
533:
509:
505:
486:
482:
437:
433:
402:
398:
361:
357:
353:
341:
329:
327:Adverse effects
317:
293:
288:
276:
240:
238:
235:(what is this?)
232:
212:
188:
180:
160:
140:
120:
104:
79:
17:
12:
11:
5:
2056:
2046:
2045:
2040:
2023:
2022:
2020:
2019:
2008:
2005:
2004:
2001:
2000:
1998:
1997:
1992:
1991:
1990:
1985:
1975:
1970:
1965:
1960:
1958:Levan beta 2→6
1955:
1950:
1949:
1948:
1932:
1921:
1920:
1919:
1903:
1894:
1889:
1888:
1887:
1882:
1877:
1872:
1867:
1862:
1851:
1849:
1843:
1842:
1840:
1839:
1834:
1828:
1822:
1816:
1810:
1808:
1800:
1799:
1797:
1796:
1790:
1788:
1782:
1781:
1779:
1778:
1773:
1768:
1762:
1760:
1758:Trisaccharides
1754:
1753:
1751:
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1715:
1710:
1704:
1702:
1693:
1689:
1688:
1685:
1684:
1682:
1681:
1680:
1679:
1669:
1663:
1661:
1657:
1656:
1654:
1653:
1652:
1651:
1646:
1644:Mannoheptulose
1637:
1635:
1629:
1628:
1626:
1625:
1624:
1623:
1618:
1613:
1605:
1604:
1603:
1598:
1593:
1588:
1578:
1577:
1576:
1571:
1566:
1561:
1556:
1551:
1546:
1541:
1530:
1528:
1522:
1521:
1519:
1518:
1517:
1516:
1506:
1505:
1504:
1499:
1491:
1490:
1489:
1484:
1479:
1474:
1465:
1463:
1457:
1456:
1454:
1453:
1452:
1451:
1443:
1442:
1441:
1436:
1427:
1425:
1419:
1418:
1416:
1415:
1414:
1413:
1405:
1404:
1403:
1401:Glyceraldehyde
1394:
1392:
1386:
1385:
1383:
1382:
1381:
1380:
1378:Glycolaldehyde
1371:
1369:
1360:
1354:
1353:
1351:
1350:
1345:
1340:
1335:
1329:
1327:
1323:
1322:
1320:
1319:
1314:
1309:
1304:
1298:
1296:
1292:
1291:
1283:
1282:
1275:
1268:
1260:
1251:
1250:
1248:
1247:
1246:
1245:
1240:
1235:
1225:
1220:
1219:
1218:
1208:
1207:
1206:
1196:
1195:
1194:
1189:
1184:
1179:
1169:
1164:
1163:
1162:
1152:
1151:
1150:
1140:
1139:
1138:
1127:
1125:
1121:
1120:
1117:
1116:
1114:
1113:
1108:
1103:
1098:
1092:
1090:
1086:
1085:
1083:
1082:
1077:
1072:
1067:
1062:
1060:Growth hormone
1056:
1054:
1050:
1049:
1046:
1045:
1043:
1042:
1037:
1031:
1029:
1023:
1022:
1020:
1019:
1014:
1013:
1012:
1007:
1002:
990:
989:
988:
986:feline "omega"
983:
978:
973:
968:
955:
946:
940:
928:
926:
920:
919:
917:
916:
915:
914:
904:
903:
902:
897:
887:
886:
885:
880:
867:
862:
851:
849:
840:
831:
827:
826:
814:
813:
806:
799:
791:
785:
784:
777:
769:
768:External links
766:
764:
763:
720:
695:
670:
643:
616:
589:
558:
531:
503:
480:
451:(8): 787–794.
431:
412:(5): 581–589.
396:
375:(2): 133–137.
354:
352:
349:
348:
347:
340:
337:
328:
325:
316:
313:
292:
289:
287:
284:
275:
272:
256:polysaccharide
247:
246:
229:
228:
225:
219:
218:
214:
213:
211:
210:
202:DTXSID30190781
197:
195:
182:
181:
179:
178:
170:
168:
162:
161:
159:
158:
150:
148:
142:
141:
139:
138:
130:
128:
122:
121:
119:
118:
114:
112:
106:
105:
103:
102:
94:
92:
86:
85:
81:
80:
78:
77:
64:
62:
56:
55:
48:
38:
37:
33:
32:
15:
9:
6:
4:
3:
2:
2055:
2044:
2041:
2039:
2036:
2035:
2033:
2018:
2010:
2009:
2006:
1996:
1993:
1989:
1986:
1984:
1981:
1980:
1979:
1976:
1974:
1971:
1969:
1966:
1964:
1961:
1959:
1956:
1954:
1953:Hemicellulose
1951:
1947:
1944:
1943:
1942:
1941:
1937:
1933:
1931:
1930:
1926:
1922:
1918:
1915:
1914:
1913:
1912:
1908:
1904:
1902:
1898:
1895:
1893:
1890:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1861:
1858:
1857:
1856:
1853:
1852:
1850:
1848:
1844:
1838:
1835:
1832:
1829:
1826:
1823:
1820:
1817:
1815:
1812:
1811:
1809:
1807:
1801:
1795:
1792:
1791:
1789:
1787:
1783:
1777:
1774:
1772:
1769:
1767:
1764:
1763:
1761:
1759:
1755:
1749:
1746:
1744:
1741:
1739:
1736:
1734:
1731:
1729:
1726:
1724:
1721:
1719:
1716:
1714:
1711:
1709:
1706:
1705:
1703:
1701:
1700:Disaccharides
1697:
1694:
1690:
1678:
1675:
1674:
1673:
1670:
1668:
1665:
1664:
1662:
1658:
1650:
1649:Sedoheptulose
1647:
1645:
1642:
1641:
1640:Ketoheptoses
1639:
1638:
1636:
1634:
1630:
1622:
1619:
1617:
1614:
1612:
1609:
1608:
1607:Deoxy sugars
1606:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1583:
1582:
1579:
1575:
1572:
1570:
1567:
1565:
1562:
1560:
1557:
1555:
1552:
1550:
1547:
1545:
1542:
1540:
1537:
1536:
1535:
1532:
1531:
1529:
1527:
1523:
1515:
1512:
1511:
1510:
1507:
1503:
1500:
1498:
1495:
1494:
1493:Ketopentoses
1492:
1488:
1485:
1483:
1480:
1478:
1475:
1473:
1470:
1469:
1468:Aldopentoses
1467:
1466:
1464:
1462:
1458:
1450:
1447:
1446:
1444:
1440:
1437:
1435:
1432:
1431:
1430:Aldotetroses
1429:
1428:
1426:
1424:
1420:
1412:
1409:
1408:
1406:
1402:
1399:
1398:
1396:
1395:
1393:
1391:
1387:
1379:
1376:
1375:
1373:
1372:
1370:
1368:
1364:
1361:
1359:
1355:
1349:
1346:
1344:
1341:
1339:
1336:
1334:
1331:
1330:
1328:
1324:
1318:
1315:
1313:
1310:
1308:
1305:
1303:
1300:
1299:
1297:
1293:
1289:
1288:carbohydrates
1281:
1276:
1274:
1269:
1267:
1262:
1261:
1258:
1244:
1241:
1239:
1236:
1234:
1231:
1230:
1229:
1226:
1224:
1221:
1217:
1214:
1213:
1212:
1209:
1205:
1202:
1201:
1200:
1197:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1174:
1173:
1172:oligopeptides
1170:
1168:
1165:
1161:
1158:
1157:
1156:
1153:
1149:
1146:
1145:
1144:
1141:
1137:
1134:
1133:
1132:
1129:
1128:
1126:
1122:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1093:
1091:
1087:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1057:
1055:
1051:
1041:
1038:
1036:
1033:
1032:
1030:
1028:
1024:
1018:
1015:
1011:
1008:
1006:
1003:
1000:
997:
996:
994:
991:
987:
984:
982:
979:
977:
974:
972:
969:
967:
963:
959:
956:
954:
950:
947:
944:
941:
939:
938:Albinterferon
936:
935:
933:
930:
929:
927:
925:
921:
913:
910:
909:
908:
905:
901:
898:
896:
893:
892:
891:
888:
884:
881:
879:
878:Pegfilgrastim
875:
871:
868:
866:
865:Eflapegrastim
863:
861:
858:
857:
856:
853:
852:
850:
848:
844:
841:
839:
835:
832:
828:
823:
819:
812:
807:
805:
800:
798:
793:
792:
789:
782:
778:
775:
772:
771:
759:
755:
751:
747:
743:
739:
735:
731:
724:
709:
705:
699:
684:
680:
674:
666:
662:
658:
654:
647:
639:
635:
631:
627:
620:
612:
608:
604:
600:
593:
585:
581:
577:
573:
569:
562:
554:
550:
546:
542:
535:
527:
523:
519:
515:
507:
499:
495:
491:
484:
476:
472:
468:
464:
459:
454:
450:
446:
442:
435:
427:
423:
419:
415:
411:
407:
400:
392:
388:
383:
378:
374:
370:
366:
359:
355:
346:
343:
342:
336:
334:
324:
322:
312:
310:
309:
304:
300:
299:
283:
281:
271:
269:
265:
261:
257:
253:
243:
236:
230:
226:
224:
220:
215:
207:
203:
199:
198:
196:
187:
183:
176:
172:
171:
169:
167:
163:
156:
152:
151:
149:
147:
143:
136:
132:
131:
129:
127:
123:
116:
115:
113:
111:
107:
100:
96:
95:
93:
91:
87:
82:
74:
69:
66:
65:
63:
61:
57:
53:
49:
47:
43:
39:
36:Clinical data
34:
30:
25:
1934:
1923:
1905:
1864:
1837:Maltodextrin
1718:Isomaltulose
1509:Deoxy sugars
1445:Ketotetrose
1348:Mutarotation
1243:Sipuleucel-T
1211:thiazolidine
1135:
1065:Immunocyanin
1027:Interleukins
992:
931:
900:Sargramostim
895:Molgramostim
736:(2): 65–70.
733:
729:
723:
711:. Retrieved
698:
686:. Retrieved
673:
656:
652:
646:
629:
625:
619:
602:
598:
592:
575:
571:
561:
544:
540:
534:
517:
513:
506:
489:
483:
448:
444:
434:
409:
405:
399:
372:
368:
358:
330:
323:is lacking.
318:
306:
296:
294:
277:
267:
251:
250:
239:
233:
227:~ 500,000 Da
1995:Xanthan gum
1983:Amylopectin
1855:Beta-glucan
1766:Maltotriose
1581:Ketohexoses
1534:Aldohexoses
1514:Deoxyribose
1449:Erythrulose
1407:Ketotriose
1397:Aldotriose
1187:Thymosin α1
1182:Thymopentin
1167:Mifamurtide
1131:beta-glucan
1035:Aldesleukin
924:Interferons
883:Lenograstim
280:beta-glucan
175:CHEBI:31770
84:Identifiers
2032:Categories
1771:Melezitose
1713:Isomaltose
1708:Cellobiose
1374:Aldodiose
1160:Roquinimex
1148:Plerixafor
1080:Tasonermin
1070:Pegademase
1040:Oprelvekin
870:Filgrastim
830:Endogenous
704:"Lentinan"
679:"Lentinan"
351:References
266:mushroom (
260:fruit body
223:Molar mass
135:6751655D1D
110:ChemSpider
99:37339-90-5
90:CAS Number
1925:Galactose
1880:Cellulose
1870:Sizofiran
1794:Stachyose
1776:Raffinose
1743:Trehalose
1728:Lactulose
1549:Galactose
1472:Arabinose
1434:Erythrose
1286:Types of
1216:Pidotimod
1124:Exogenous
1111:Vitamin D
1106:Poly ICLC
1075:Prolactin
838:Cytokines
274:Chemistry
46:Drugs.com
2017:Category
1946:Glycogen
1929:Galactan
1907:Fructose
1892:Chitosan
1865:Lentinan
1814:Acarbose
1748:Turanose
1692:Multiple
1633:Heptoses
1621:Rhamnose
1616:Fuculose
1601:Tagatose
1586:Fructose
1502:Xylulose
1497:Ribulose
1461:Pentoses
1423:Tetroses
1326:Geometry
1317:Pyranose
1312:Furanose
1228:vaccines
1192:Thymulin
1136:Lentinan
912:Ancestim
781:Lentinan
774:Lentinan
713:June 10,
688:June 10,
665:19453066
638:19579616
611:19579640
584:19596936
553:19596954
526:10522061
498:16897983
475:33140754
467:18670743
426:12470439
391:10190187
339:See also
321:efficacy
298:in vitro
286:Research
264:shiitake
252:Lentinan
242:(verify)
60:ATC code
21:Lentinan
1988:Amylose
1936:Glucose
1911:Fructan
1901:Dextran
1897:Dextrin
1875:Zymosan
1738:Sucrose
1733:Maltose
1723:Lactose
1672:Nonoses
1667:Octoses
1660:Above 7
1596:Sorbose
1591:Psicose
1569:Mannose
1554:Glucose
1544:Altrose
1526:Hexoses
1439:Threose
1390:Trioses
1295:General
1001:natural
945:natural
758:7320474
750:1395630
308:in vivo
76:)
70: (
68:L03AX01
1978:Starch
1973:Pectin
1968:Mannan
1963:Lignin
1940:Glucan
1917:Inulin
1885:Chitin
1611:Fucose
1574:Talose
1559:Gulose
1539:Allose
1487:Xylose
1482:Ribose
1477:Lyxose
1367:Dioses
1343:Epimer
1333:Anomer
1307:Ketose
1302:Aldose
890:GM-CSF
756:
748:
663:
636:
609:
582:
551:
524:
496:
473:
465:
424:
389:
155:D01695
1833:(IMO)
1827:(GOS)
1821:(FOS)
1803:Other
1564:Idose
1089:Other
932:alpha
855:G-CSF
754:S2CID
683:WebMD
471:S2CID
254:is a
166:ChEBI
993:beta
746:PMID
715:2017
690:2017
661:PMID
634:PMID
607:PMID
580:PMID
549:PMID
522:PMID
494:PMID
463:PMID
422:PMID
387:PMID
303:U937
146:KEGG
126:UNII
117:none
42:AHFS
907:SCF
822:L03
738:doi
453:doi
414:doi
377:doi
295:An
270:).
262:of
191:EPA
73:WHO
2034::
1938:/
1927:/
1909:/
1899:/
995::
964:/
960:/
951:/
934::
876:/
872:/
752:.
744:.
734:27
732:.
706:.
681:.
657:56
655:.
630:56
628:.
603:56
601:.
576:29
574:.
570:.
545:29
543:.
518:46
516:.
469:.
461:.
449:25
447:.
443:.
420:.
408:.
385:.
373:13
371:.
367:.
335:.
1279:e
1272:t
1265:v
824:)
820:(
810:e
803:t
796:v
783:.
760:.
740::
717:.
692:.
667:.
640:.
613:.
586:.
555:.
528:.
500:.
477:.
455::
428:.
416::
410:8
393:.
379::
193:)
189:(
44:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
