239:
214:
2581:
2566:
447:
2611:
245:
2596:
31:
1947:
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999).
57:
2379:
Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP (Apr 2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex".
1607:
Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP (Apr 2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex".
1292:
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW (Apr 1999). "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase".
252:
1155:. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.
1789:
Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JW (Apr 1999). "Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1".
1991:
Seddiqi N, Charbonnier F, Goudou D, Belkadi L, Rieger F, Alliel PM (Dec 1999). "Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1".
2133:
Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (May 2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome".
2425:
Yoshida Y, Chiba T, Tokunaga F, Kawasaki H, Iwai K, Suzuki T, Ito Y, Matsuoka K, Yoshida M, Tanaka K, Tai T (Jul 2002). "E3 ubiquitin ligase that recognizes sugar chains".
2470:
Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC (Aug 2002).
2258:"The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34"
870:
1749:
Panasyuk G, Nemazanyy I, Filonenko V, Gout I (May 2008). "Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1".
851:
175:
2580:
2565:
2057:"The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1"
1274:
2472:"Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase"
1256:
2223:"Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase"
2012:
Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ (Apr 2000).
1072:
2610:
1457:
Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008).
1394:
2595:
2639:
2545:
2221:
Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (Aug 2001).
1239:
1661:"The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A"
1243:
1828:"Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha"
1347:"ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity"
238:
213:
54:
896:
1906:"The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2"
155:
1702:"Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation"
1164:
251:
2538:
2180:"Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins"
244:
142:
1010:
1006:
1002:
163:
1659:
Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V (Jul 2008).
2014:"Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha"
1036:
981:
1517:"CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex"
227:
2531:
2483:
2434:
2389:
2304:
2142:
1961:
1874:
1798:
1617:
1302:
183:
8:
2487:
2438:
2393:
2308:
2146:
1965:
1878:
1802:
1621:
1306:
2458:
2413:
2178:
Fukuchi M, Imamura T, Chiba T, Ebisawa T, Kawabata M, Tanaka K, Miyazono K (May 2001).
2166:
1726:
1701:
1641:
1485:
1458:
1376:
187:
2506:
2471:
2116:
2099:
1930:
1905:
1887:
1862:
1844:
1827:
1543:
1516:
1363:
1346:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
629:
624:
619:
614:
609:
604:
599:
594:
589:
584:
579:
574:
569:
564:
559:
543:
538:
533:
528:
523:
518:
513:
508:
503:
498:
493:
488:
2511:
2450:
2405:
2367:
2332:
2327:
2292:
2279:
2244:
2209:
2204:
2179:
2158:
2121:
2086:
2081:
2072:
2056:
2043:
2038:
2013:
2000:
1979:
1935:
1892:
1849:
1814:
1766:
1731:
1682:
1633:
1589:
1548:
1490:
1434:
1368:
1318:
135:
47:
2170:
2029:
1380:
167:
2501:
2491:
2462:
2442:
2417:
2397:
2357:
2322:
2312:
2293:"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy"
2269:
2234:
2199:
2191:
2150:
2111:
2076:
2068:
2033:
2025:
1969:
1925:
1917:
1882:
1839:
1806:
1758:
1721:
1713:
1672:
1645:
1625:
1579:
1538:
1528:
1480:
1470:
1424:
1358:
1310:
331:
262:
1677:
1660:
681:
regulation of transcription from RNA polymerase II promoter in response to hypoxia
1810:
1314:
1213:
306:
191:
1279:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1261:
National Center for
Biotechnology Information, U.S. National Library of Medicine
751:
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
2476:
Proceedings of the
National Academy of Sciences of the United States of America
2297:
Proceedings of the
National Academy of Sciences of the United States of America
1762:
1717:
1521:
Proceedings of the
National Academy of Sciences of the United States of America
2633:
1459:"SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation"
475:
2154:
424:
345:
2515:
2496:
2454:
2409:
2371:
2362:
2345:
2344:
Kim J, Kim JH, Lee SH, Kim DH, Kang HY, Bae SH, Pan ZQ, Seo YS (Jul 2002).
2336:
2317:
2283:
2274:
2257:
2248:
2239:
2222:
2213:
2162:
2125:
2090:
2047:
2004:
1983:
1939:
1921:
1896:
1853:
1818:
1770:
1735:
1686:
1658:
1637:
1593:
1584:
1567:
1566:
Kim J, Kim JH, Lee SH, Kim DH, Kang HY, Bae SH, Pan ZQ, Seo YS (Jul 2002).
1552:
1533:
1494:
1475:
1438:
1429:
1412:
1372:
1322:
446:
324:
204:
2195:
1151:
This gene encodes an evolutionarily conserved protein that interacts with
1117:
1112:
1413:"TIP120A associates with cullins and modulates ubiquitin ligase activity"
939:
2589:: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
2574:: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
2446:
30:
1700:
Duda DM, Borg LA, Scott DC, Hunt HW, Hammel M, Schulman BA (Sep 2008).
766:
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
221:
171:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
815:
290:
277:
179:
2401:
1826:
Tan P, Fuchs SY, Chen A, Wu K, Gomez C, Ronai Z, Pan ZQ (Apr 1999).
1629:
1974:
1949:
1101:
2100:"In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3"
1411:
Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003).
1207:
1133:
925:
882:
800:
796:
771:
proteasome-mediated ubiquitin-dependent protein catabolic process
2291:
Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL (Dec 2001).
159:
2055:
Furukawa M, Zhang Y, McCarville J, Ohta T, Xiong Y (Nov 2000).
1990:
1904:
Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW (Nov 1999).
1861:
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Oct 1999).
1152:
1085:
837:
455:
2523:
2011:
1748:
2469:
1190:
1172:
701:
nucleotide-excision repair, preincision complex stabilization
2424:
741:
negative regulation of G2/M transition of mitotic cell cycle
2132:
2054:
1201:
1196:
1184:
1178:
1140:
2177:
1344:
2346:"The novel human DNA helicase hFBH1 is an F-box protein"
1788:
1568:"The novel human DNA helicase hFBH1 is an F-box protein"
1291:
721:
nucleotide-excision repair, preincision complex assembly
314:
2619:: Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex
2378:
1946:
1606:
1345:
Ohta T, Michel JJ, Schottelius AJ, Xiong Y (Apr 1999).
2220:
2097:
1903:
1860:
1456:
786:
nucleotide-excision repair, DNA incision, 3'-to lesion
726:
nucleotide-excision repair, DNA incision, 5'-to lesion
696:
negative regulation of canonical Wnt signaling pathway
2290:
436:
1751:
2604:: Crystal Structure of The Cand1-Cul1-Roc1 Complex
1235:
1233:
1231:
646:nucleotide-excision repair, DNA damage recognition
2098:Maeda I, Ohta T, Koizumi H, Fukuda M (Apr 2001).
1699:
1514:
261:
2631:
781:nucleotide-excision repair, DNA duplex unwinding
686:transcription-coupled nucleotide-excision repair
1410:
1228:
16:Protein-coding gene in the species Homo sapiens
1825:
1515:Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002).
1510:
1508:
1506:
1504:
1452:
1450:
1448:
1406:
1404:
1340:
1338:
1336:
1334:
1332:
2539:
776:ubiquitin-dependent protein catabolic process
2343:
2255:
1742:
1693:
1652:
1600:
1565:
1559:
1501:
1445:
1401:
1329:
1285:
1240:GRCh38: Ensembl release 89: ENSG00000100387
2546:
2532:
364:Skeletal muscle tissue of rectus abdominis
2505:
2495:
2361:
2326:
2316:
2273:
2238:
2203:
2115:
2080:
2037:
1973:
1950:"The DNA sequence of human chromosome 22"
1929:
1886:
1843:
1725:
1676:
1583:
1542:
1532:
1484:
1474:
1428:
1362:
2256:Wu K, Chen A, Tan P, Pan ZQ (Jan 2002).
756:interleukin-1-mediated signaling pathway
691:nucleotide-excision repair, DNA incision
671:global genome nucleotide-excision repair
661:cellular response to DNA damage stimulus
746:post-translational protein modification
2632:
1863:"A family of mammalian F-box proteins"
610:Cul4B-RING E3 ubiquitin ligase complex
605:Cul4A-RING E3 ubiquitin ligase complex
524:ubiquitin-protein transferase activity
2527:
1387:
630:Cul4-RING E3 ubiquitin ligase complex
266:
225:
220:
146:, BA554C12.1, RNF75, ROC1, ring-box 1
625:nuclear SCF ubiquitin ligase complex
565:cullin-RING ubiquitin ligase complex
2350:The Journal of Biological Chemistry
2262:The Journal of Biological Chemistry
2227:The Journal of Biological Chemistry
1572:The Journal of Biological Chemistry
1463:The Journal of Biological Chemistry
1417:The Journal of Biological Chemistry
509:ubiquitin-ubiquitin ligase activity
13:
1781:
600:Cul7-RING ubiquitin ligase complex
595:Cul5-RING ubiquitin ligase complex
590:Cul3-RING ubiquitin ligase complex
585:Cul2-RING ubiquitin ligase complex
544:protein-containing complex binding
14:
2651:
1136:that in humans is encoded by the
494:ubiquitin protein ligase activity
2609:
2594:
2579:
2564:
2073:10.1128/MCB.20.21.8185-8197.2000
519:ubiquitin protein ligase binding
445:
250:
243:
237:
212:
29:
2553:
2030:10.1128/MCB.20.7.2326-2333.2000
1158:
2061:Molecular and Cellular Biology
2018:Molecular and Cellular Biology
1993:Cellular and Molecular Biology
1395:"Entrez Gene: RBX1 ring-box 1"
1267:
1249:
456:More reference expression data
425:More reference expression data
1:
2184:Molecular Biology of the Cell
2117:10.1016/S0014-5793(01)02343-2
1888:10.1016/S0960-9822(00)80021-4
1845:10.1016/S1097-2765(00)80481-5
1678:10.1158/0008-5472.CAN-07-6162
1364:10.1016/S1097-2765(00)80482-7
1221:
489:cullin family protein binding
235:
2640:Genes on human chromosome 22
1811:10.1126/science.284.5414.662
1315:10.1126/science.284.5414.657
575:SCF ubiquitin ligase complex
534:transcription factor binding
7:
1146:
10:
2656:
1763:10.1016/j.bbrc.2008.02.016
1718:10.1016/j.cell.2008.07.022
716:protein polyubiquitination
651:protein monoubiquitination
529:NEDD8 transferase activity
2559:
1275:"Mouse PubMed Reference:"
1257:"Human PubMed Reference:"
1116:
1111:
1107:
1100:
1084:
1067:
1054:
1050:
1033:
1029:
1022:
999:
995:
978:
974:
967:
956:
952:
937:
933:
924:
913:
909:
894:
890:
881:
868:
864:
849:
845:
836:
821:
814:
810:
794:
676:protein catabolic process
474:
470:
453:
444:
435:
422:
409:
405:
352:
343:
313:
305:
301:
284:
271:
234:
211:
202:
198:
153:
150:
140:
133:
128:
73:
68:
51:
46:
41:
37:
28:
23:
1073:Chr 22: 40.95 – 40.97 Mb
2155:10.1126/science.1059780
1910:Genes & Development
1163:RBX1 has been shown to
2497:10.1073/pnas.162424199
2363:10.1074/jbc.M201612200
2318:10.1073/pnas.251541198
2275:10.1074/jbc.M108008200
2240:10.1074/jbc.M103093200
1922:10.1101/gad.13.22.2928
1585:10.1074/jbc.M201612200
1534:10.1073/pnas.252646399
1476:10.1074/jbc.M804440200
1430:10.1074/jbc.M213070200
761:protein ubiquitination
52:Human UniProt search:
2196:10.1091/mbc.12.5.1431
731:Wnt signaling pathway
376:palpebral conjunctiva
228:Chromosome 22 (human)
736:SCF complex assembly
539:transferase activity
69:List of PDB id codes
42:Available structures
2488:2002PNAS...9910353B
2447:10.1038/nature00890
2439:2002Natur.418..438Y
2394:2002Natur.416..703Z
2309:2001PNAS...9814440G
2147:2001Sci...292.1382L
1966:1999Natur.402..489D
1879:1999CBio....9.1180W
1803:1999Sci...284..662S
1622:2002Natur.416..703Z
1307:1999Sci...284..657K
666:protein neddylation
1130:RING-box protein 1
639:Biological process
553:Cellular component
482:Molecular function
2627:
2626:
1127:
1126:
1123:
1122:
1096:
1095:
1063:
1062:
1044:
1043:
1018:
1017:
989:
988:
963:
962:
946:
945:
920:
919:
903:
902:
877:
876:
858:
857:
806:
805:
504:metal ion binding
466:
465:
462:
461:
431:
430:
418:
417:
399:
398:
356:periodontal fiber
297:
296:
124:
123:
120:
119:
2647:
2613:
2598:
2583:
2568:
2548:
2541:
2534:
2525:
2524:
2519:
2509:
2499:
2466:
2433:(6896): 438–42.
2421:
2375:
2365:
2340:
2330:
2320:
2287:
2277:
2252:
2242:
2233:(32): 29748–53.
2217:
2207:
2174:
2141:(5520): 1382–5.
2129:
2119:
2094:
2084:
2051:
2041:
2008:
1987:
1977:
1960:(6761): 489–95.
1943:
1933:
1900:
1890:
1857:
1847:
1822:
1775:
1774:
1746:
1740:
1739:
1729:
1697:
1691:
1690:
1680:
1656:
1650:
1649:
1604:
1598:
1597:
1587:
1563:
1557:
1556:
1546:
1536:
1512:
1499:
1498:
1488:
1478:
1469:(48): 33211–20.
1454:
1443:
1442:
1432:
1423:(18): 15905–10.
1408:
1399:
1398:
1391:
1385:
1384:
1366:
1342:
1327:
1326:
1301:(5414): 657–61.
1289:
1283:
1282:
1271:
1265:
1264:
1253:
1247:
1237:
1109:
1108:
1080:
1075:
1058:
1048:
1047:
1039:
1027:
1026:
1023:RefSeq (protein)
1013:
993:
992:
984:
972:
971:
950:
949:
931:
930:
907:
906:
888:
887:
862:
861:
843:
842:
812:
811:
499:zinc ion binding
472:
471:
458:
449:
442:
441:
427:
403:
402:
348:
346:Top expressed in
341:
340:
320:
319:
303:
302:
293:
280:
269:
254:
247:
241:
230:
216:
200:
199:
194:
192:RBX1 - orthologs
145:
138:
115:
66:
65:
60:
39:
38:
33:
21:
20:
2655:
2654:
2650:
2649:
2648:
2646:
2645:
2644:
2630:
2629:
2628:
2623:
2620:
2614:
2605:
2599:
2590:
2584:
2575:
2569:
2555:
2552:
2522:
2482:(16): 10353–8.
2402:10.1038/416703a
2388:(6882): 703–9.
2356:(27): 24530–7.
2303:(25): 14440–5.
2067:(21): 8185–97.
1916:(22): 2928–33.
1867:Current Biology
1797:(5414): 662–5.
1784:
1782:Further reading
1779:
1778:
1747:
1743:
1712:(6): 995–1006.
1698:
1694:
1671:(13): 5014–22.
1665:Cancer Research
1657:
1653:
1630:10.1038/416703a
1616:(6882): 703–9.
1605:
1601:
1578:(27): 24530–7.
1564:
1560:
1527:(26): 16601–6.
1513:
1502:
1455:
1446:
1409:
1402:
1393:
1392:
1388:
1343:
1330:
1290:
1286:
1273:
1272:
1268:
1255:
1254:
1250:
1238:
1229:
1224:
1219:
1214:P70-S6 Kinase 1
1161:
1149:
1118:View/Edit Mouse
1113:View/Edit Human
1078:
1071:
1068:Location (UCSC)
1056:
1035:
1009:
1005:
1001:
980:
897:ENSG00000100387
790:
634:
548:
514:protein binding
454:
423:
414:
395:
390:
386:
382:
378:
374:
370:
368:right ventricle
366:
362:
360:trabecular bone
358:
344:
288:
275:
267:
257:
256:
255:
248:
226:
203:Gene location (
154:
141:
134:
75:
53:
17:
12:
11:
5:
2653:
2643:
2642:
2625:
2624:
2622:
2621:
2615:
2608:
2606:
2600:
2593:
2591:
2585:
2578:
2576:
2570:
2563:
2560:
2557:
2556:
2551:
2550:
2543:
2536:
2528:
2521:
2520:
2467:
2422:
2376:
2341:
2288:
2253:
2218:
2190:(5): 1431–43.
2175:
2130:
2095:
2052:
2024:(7): 2326–33.
2009:
1988:
1975:10.1038/990031
1944:
1901:
1873:(20): 1180–2.
1858:
1832:Molecular Cell
1823:
1785:
1783:
1780:
1777:
1776:
1741:
1692:
1651:
1599:
1558:
1500:
1444:
1400:
1386:
1351:Molecular Cell
1328:
1284:
1266:
1248:
1226:
1225:
1223:
1220:
1218:
1217:
1211:
1205:
1199:
1194:
1188:
1182:
1176:
1169:
1160:
1157:
1148:
1145:
1125:
1124:
1121:
1120:
1115:
1105:
1104:
1098:
1097:
1094:
1093:
1091:
1089:
1082:
1081:
1076:
1069:
1065:
1064:
1061:
1060:
1052:
1051:
1045:
1042:
1041:
1031:
1030:
1024:
1020:
1019:
1016:
1015:
997:
996:
990:
987:
986:
976:
975:
969:
965:
964:
961:
960:
954:
953:
947:
944:
943:
935:
934:
928:
922:
921:
918:
917:
911:
910:
904:
901:
900:
892:
891:
885:
879:
878:
875:
874:
866:
865:
859:
856:
855:
847:
846:
840:
834:
833:
828:
823:
819:
818:
808:
807:
804:
803:
792:
791:
789:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
642:
640:
636:
635:
633:
632:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
577:
572:
567:
562:
556:
554:
550:
549:
547:
546:
541:
536:
531:
526:
521:
516:
511:
506:
501:
496:
491:
485:
483:
479:
478:
468:
467:
464:
463:
460:
459:
451:
450:
439:
433:
432:
429:
428:
420:
419:
416:
415:
413:
410:
407:
406:
400:
397:
396:
394:
393:
389:
388:olfactory bulb
385:
381:
377:
373:
369:
365:
361:
357:
353:
350:
349:
337:
336:
328:
317:
311:
310:
307:RNA expression
299:
298:
295:
294:
286:
282:
281:
273:
270:
265:
259:
258:
249:
242:
236:
232:
231:
224:
218:
217:
209:
208:
196:
195:
152:
148:
147:
139:
131:
130:
126:
125:
122:
121:
118:
117:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
2652:
2641:
2638:
2637:
2635:
2618:
2612:
2607:
2603:
2597:
2592:
2588:
2582:
2577:
2573:
2567:
2562:
2561:
2558:
2549:
2544:
2542:
2537:
2535:
2530:
2529:
2526:
2517:
2513:
2508:
2503:
2498:
2493:
2489:
2485:
2481:
2477:
2473:
2468:
2464:
2460:
2456:
2452:
2448:
2444:
2440:
2436:
2432:
2428:
2423:
2419:
2415:
2411:
2407:
2403:
2399:
2395:
2391:
2387:
2383:
2377:
2373:
2369:
2364:
2359:
2355:
2351:
2347:
2342:
2338:
2334:
2329:
2324:
2319:
2314:
2310:
2306:
2302:
2298:
2294:
2289:
2285:
2281:
2276:
2271:
2268:(1): 516–27.
2267:
2263:
2259:
2254:
2250:
2246:
2241:
2236:
2232:
2228:
2224:
2219:
2215:
2211:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2136:
2131:
2127:
2123:
2118:
2113:
2109:
2105:
2101:
2096:
2092:
2088:
2083:
2078:
2074:
2070:
2066:
2062:
2058:
2053:
2049:
2045:
2040:
2035:
2031:
2027:
2023:
2019:
2015:
2010:
2006:
2002:
1999:(8): 1131–7.
1998:
1994:
1989:
1985:
1981:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1945:
1941:
1937:
1932:
1927:
1923:
1919:
1915:
1911:
1907:
1902:
1898:
1894:
1889:
1884:
1880:
1876:
1872:
1868:
1864:
1859:
1855:
1851:
1846:
1841:
1838:(4): 527–33.
1837:
1833:
1829:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1796:
1792:
1787:
1786:
1772:
1768:
1764:
1760:
1757:(2): 339–43.
1756:
1752:
1745:
1737:
1733:
1728:
1723:
1719:
1715:
1711:
1707:
1703:
1696:
1688:
1684:
1679:
1674:
1670:
1666:
1662:
1655:
1647:
1643:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1603:
1595:
1591:
1586:
1581:
1577:
1573:
1569:
1562:
1554:
1550:
1545:
1540:
1535:
1530:
1526:
1522:
1518:
1511:
1509:
1507:
1505:
1496:
1492:
1487:
1482:
1477:
1472:
1468:
1464:
1460:
1453:
1451:
1449:
1440:
1436:
1431:
1426:
1422:
1418:
1414:
1407:
1405:
1396:
1390:
1382:
1378:
1374:
1370:
1365:
1360:
1357:(4): 535–41.
1356:
1352:
1348:
1341:
1339:
1337:
1335:
1333:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1288:
1280:
1276:
1270:
1262:
1258:
1252:
1245:
1241:
1236:
1234:
1232:
1227:
1215:
1212:
1209:
1206:
1203:
1200:
1198:
1195:
1192:
1189:
1186:
1183:
1180:
1177:
1174:
1171:
1170:
1168:
1166:
1156:
1154:
1144:
1142:
1139:
1135:
1131:
1119:
1114:
1110:
1106:
1103:
1099:
1092:
1090:
1087:
1083:
1077:
1074:
1070:
1066:
1059:
1053:
1049:
1046:
1040:
1038:
1032:
1028:
1025:
1021:
1014:
1012:
1008:
1004:
998:
994:
991:
985:
983:
977:
973:
970:
968:RefSeq (mRNA)
966:
959:
955:
951:
948:
942:
941:
936:
932:
929:
927:
923:
916:
912:
908:
905:
899:
898:
893:
889:
886:
884:
880:
873:
872:
867:
863:
860:
854:
853:
848:
844:
841:
839:
835:
832:
829:
827:
824:
820:
817:
813:
809:
802:
798:
793:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
711:viral process
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
643:
641:
638:
637:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
557:
555:
552:
551:
545:
542:
540:
537:
535:
532:
530:
527:
525:
522:
520:
517:
515:
512:
510:
507:
505:
502:
500:
497:
495:
492:
490:
487:
486:
484:
481:
480:
477:
476:Gene ontology
473:
469:
457:
452:
448:
443:
440:
438:
434:
426:
421:
411:
408:
404:
401:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
354:
351:
347:
342:
339:
338:
335:
333:
329:
327:
326:
322:
321:
318:
316:
312:
308:
304:
300:
292:
287:
283:
279:
274:
264:
260:
253:
246:
240:
233:
229:
223:
219:
215:
210:
206:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
149:
144:
137:
132:
127:
116:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2616:
2601:
2586:
2571:
2479:
2475:
2430:
2426:
2385:
2381:
2353:
2349:
2300:
2296:
2265:
2261:
2230:
2226:
2187:
2183:
2138:
2134:
2110:(3): 181–5.
2107:
2104:FEBS Letters
2103:
2064:
2060:
2021:
2017:
1996:
1992:
1957:
1953:
1913:
1909:
1870:
1866:
1835:
1831:
1794:
1790:
1754:
1750:
1744:
1709:
1705:
1695:
1668:
1664:
1654:
1613:
1609:
1602:
1575:
1571:
1561:
1524:
1520:
1466:
1462:
1420:
1416:
1389:
1354:
1350:
1298:
1294:
1287:
1278:
1269:
1260:
1251:
1162:
1159:Interactions
1150:
1137:
1129:
1128:
1055:
1034:
1011:XM_006537452
1007:XM_006536722
1003:XM_006525232
1000:
979:
957:
938:
914:
895:
869:
850:
830:
825:
656:MAPK cascade
330:
323:
151:External IDs
74:
18:
2554:PDB gallery
620:nucleoplasm
580:VCB complex
392:oral cavity
289:40,973,309
276:40,951,347
129:Identifiers
1246:, May 2017
1222:References
706:DNA repair
384:C1 segment
334:(ortholog)
172:HomoloGene
1037:NP_055063
982:NM_014248
871:100043674
816:Orthologs
560:cytoplasm
380:beta cell
180:GeneCards
2634:Category
2516:12149480
2455:12140560
2410:11961546
2372:11956208
2337:11717410
2284:11675391
2249:11384984
2214:11359933
2171:14224920
2163:11337588
2126:11311237
2091:11027288
2048:10713156
2005:10643962
1984:10591208
1940:10579999
1897:10531037
1854:10230406
1819:10213692
1771:18279656
1736:18805092
1687:18593899
1638:11961546
1594:11956208
1553:12481031
1495:18826954
1439:12609982
1381:19371828
1373:10230407
1323:10213691
1242:–
1165:interact
1147:Function
1102:Wikidata
795:Sources:
372:monocyte
2484:Bibcode
2463:4424996
2435:Bibcode
2418:4423882
2390:Bibcode
2305:Bibcode
2143:Bibcode
2135:Science
1962:Bibcode
1875:Bibcode
1799:Bibcode
1791:Science
1727:2628631
1646:4423882
1618:Bibcode
1486:2586271
1303:Bibcode
1295:Science
1244:Ensembl
1208:DCUN1D1
1153:cullins
1134:protein
926:UniProt
883:Ensembl
822:Species
801:QuickGO
615:nucleus
570:cytosol
309:pattern
268:22q13.2
168:3710517
136:Aliases
2514:
2507:124918
2504:
2461:
2453:
2427:Nature
2416:
2408:
2382:Nature
2370:
2335:
2325:
2282:
2247:
2212:
2202:
2169:
2161:
2124:
2089:
2079:
2046:
2036:
2003:
1982:
1954:Nature
1938:
1931:317157
1928:
1895:
1852:
1817:
1769:
1734:
1724:
1685:
1644:
1636:
1610:Nature
1592:
1551:
1544:139190
1541:
1493:
1483:
1437:
1379:
1371:
1321:
1210:, and
1167:with:
1088:search
1086:PubMed
940:P62877
838:Entrez
437:BioGPS
160:603814
2459:S2CID
2414:S2CID
2328:64700
2205:34595
2167:S2CID
2082:86428
2039:85397
1642:S2CID
1377:S2CID
1191:CUL4A
1173:CAND1
1132:is a
831:Mouse
826:Human
797:Amigo
332:Mouse
325:Human
272:Start
205:Human
2617:2hye
2602:1u6g
2587:1ldk
2572:1ldj
2512:PMID
2451:PMID
2406:PMID
2368:PMID
2333:PMID
2280:PMID
2245:PMID
2210:PMID
2159:PMID
2122:PMID
2087:PMID
2044:PMID
2001:PMID
1980:PMID
1936:PMID
1893:PMID
1850:PMID
1815:PMID
1767:PMID
1732:PMID
1706:Cell
1683:PMID
1634:PMID
1590:PMID
1549:PMID
1491:PMID
1435:PMID
1369:PMID
1319:PMID
1202:CUL7
1197:CUL5
1185:CUL2
1179:CUL1
1141:gene
1138:RBX1
852:9978
315:Bgee
263:Band
222:Chr.
184:RBX1
176:6872
156:OMIM
143:RBX1
113:4P5O
109:4F52
105:3RTR
101:3DQV
97:3DPL
93:2LGV
89:2HYE
85:1U6G
81:1LDK
77:1LDJ
58:RCSB
55:PDBe
24:RBX1
2502:PMC
2492:doi
2443:doi
2431:418
2398:doi
2386:416
2358:doi
2354:277
2323:PMC
2313:doi
2270:doi
2266:277
2235:doi
2231:276
2200:PMC
2192:doi
2151:doi
2139:292
2112:doi
2108:494
2077:PMC
2069:doi
2034:PMC
2026:doi
1970:doi
1958:402
1926:PMC
1918:doi
1883:doi
1840:doi
1807:doi
1795:284
1759:doi
1755:369
1722:PMC
1714:doi
1710:134
1673:doi
1626:doi
1614:416
1580:doi
1576:277
1539:PMC
1529:doi
1481:PMC
1471:doi
1467:283
1425:doi
1421:278
1359:doi
1311:doi
1299:284
1079:n/a
1057:n/a
958:n/a
915:n/a
412:n/a
285:End
188:OMA
164:MGI
48:PDB
2636::
2510:.
2500:.
2490:.
2480:99
2478:.
2474:.
2457:.
2449:.
2441:.
2429:.
2412:.
2404:.
2396:.
2384:.
2366:.
2352:.
2348:.
2331:.
2321:.
2311:.
2301:98
2299:.
2295:.
2278:.
2264:.
2260:.
2243:.
2229:.
2225:.
2208:.
2198:.
2188:12
2186:.
2182:.
2165:.
2157:.
2149:.
2137:.
2120:.
2106:.
2102:.
2085:.
2075:.
2065:20
2063:.
2059:.
2042:.
2032:.
2022:20
2020:.
2016:.
1997:45
1995:.
1978:.
1968:.
1956:.
1952:.
1934:.
1924:.
1914:13
1912:.
1908:.
1891:.
1881:.
1869:.
1865:.
1848:.
1834:.
1830:.
1813:.
1805:.
1793:.
1765:.
1753:.
1730:.
1720:.
1708:.
1704:.
1681:.
1669:68
1667:.
1663:.
1640:.
1632:.
1624:.
1612:.
1588:.
1574:.
1570:.
1547:.
1537:.
1525:99
1523:.
1519:.
1503:^
1489:.
1479:.
1465:.
1461:.
1447:^
1433:.
1419:.
1415:.
1403:^
1375:.
1367:.
1353:.
1349:.
1331:^
1317:.
1309:.
1297:.
1277:.
1259:.
1230:^
1143:.
799:/
291:bp
278:bp
186:;
182::
178:;
174::
170:;
166::
162:;
158::
111:,
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
2547:e
2540:t
2533:v
2518:.
2494::
2486::
2465:.
2445::
2437::
2420:.
2400::
2392::
2374:.
2360::
2339:.
2315::
2307::
2286:.
2272::
2251:.
2237::
2216:.
2194::
2173:.
2153::
2145::
2128:.
2114::
2093:.
2071::
2050:.
2028::
2007:.
1986:.
1972::
1964::
1942:.
1920::
1899:.
1885::
1877::
1871:9
1856:.
1842::
1836:3
1821:.
1809::
1801::
1773:.
1761::
1738:.
1716::
1689:.
1675::
1648:.
1628::
1620::
1596:.
1582::
1555:.
1531::
1497:.
1473::
1441:.
1427::
1397:.
1383:.
1361::
1355:3
1325:.
1313::
1305::
1281:.
1263:.
1216:.
1204:,
1193:,
1187:,
1181:,
1175:,
207:)
190::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
