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Thrombosis

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than three hours of ischemia followed by one hour of reperfusion. In ST-elevation myocardial infarction (STEMI), IRI contributes up to 50% of final infarct size despite timely primary percutaneous coronary intervention. This is a key reason for the continued high mortality and morbidity in these conditions, despite endovascular reperfusion treatments and continuous efforts to improve timeliness and access to these treatments. Hence, protective therapies are required to attenuate IRI alongside reperfusion in acute ischemic conditions to improve clinical outcomes. Therapeutic strategies that have potential to improve clinical outcomes in reperfused STEMI patients include
1472:), by external compression on a blood vessel when a solid tumor is present, or (more rarely) extension into the vasculature (for example, renal cell cancers extending into the renal veins). Also, treatments for cancer (radiation, chemotherapy) often cause additional hypercoagulability. There are scores that correlate different aspects of patient data (comorbidities, vital signs, and others) to risk of thrombosis, such as the POMPE-C, which stratifies risk of mortality due to pulmonary embolism in patients with cancer, who typically have higher rates of thrombosis. Also, there are several predictive scores for thromboembolic events, such as Padua, Khorana, and 52: 3782:
Vries J, de Kort PL, van Rooij WJ, van den Berg JS, van Hasselt BA, Aerden LA, Dallinga RJ, Visser MC, Bot JC, Vroomen PC, Eshghi O, Schreuder TH, Heijboer RJ, Keizer K, Tielbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers ME, Jenniskens SF, Beenen LF, van den Berg R, Koudstaal PJ, van Zwam WH, Roos YB, van der Lugt A, van Oostenbrugge RJ, Majoie CB, Dippel DW, et al. (January 1, 2015).
1786:(thrombolytics and/or anticoagulants), and surgery. The evidence supporting these treatment approaches is weak. For anticoagulant treatment, it is not clear if unfractionated and/or low molecular weight heparin treatment is effective at decreasing mortality and serious adverse events in this population. There is also insufficient evidence to understand the risk of adverse effects associated with these treatment approaches in term or preterm infants. 562: 4240: 1774:(RIC), exenatide, and metoprolol. These have emerged amongst a multitude of cardioprotective interventions investigated with largely neutral clinical data. Of these, RIC has the most robust clinical evidence, especially in the context of STEMI, but also emerging for other indications such as acute ischemic stroke and aneurysmal subarachnoid hemorrhage. 1351:. Generally speaking the risk for thrombosis increases over the life course of individuals, depending on life style factors like smoking, diet, and physical activity, the presence of other diseases like cancer or autoimmune disease, while also platelet properties change in aging individuals which is an important consideration as well. 1591:) in the area past the occlusion. Venous thrombosis can lead to pulmonary embolism when the migrated embolus becomes lodged in the lung. In people with a "shunt" (a connection between the pulmonary and systemic circulation), either in the heart or in the lung, a venous clot can also end up in the arteries and cause arterial embolism. 1620:
following surgery is common if there are no issues with bleeding. Generally, a risk-benefit analysis is required, as all anticoagulants lead to an increased risk of bleeding. In people admitted to hospital, thrombosis is a major cause for complications and occasionally death. In the UK, for instance,
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Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, van Walderveen MA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama Ă  Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SF, van Dijk LC, Kappelle LJ, Lo RH, van Dijk EJ, de
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With reperfusion comes ischemia/reperfusion (IR) injury (IRI), which paradoxically causes cell death in reperfused tissue and contributes significantly to post-reperfusion mortality and morbidity. For example, in a feline model of intestinal ischemia, four hours of ischemia resulted in less injury
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Endothelial injury is almost invariably involved in the formation of thrombi in arteries, as high rates of blood flow normally hinder clot formation. In addition, arterial and cardiac clots are normally rich in platelets–which are required for clot formation in areas under high stress due to blood
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Cancer-associated thrombosis can result from: (1) stasis, i.e., direct pressure on blood vessels by the tumor mass, poor performance status, and bed rest following surgical procedures; (2) iatrogenic, due to treatment with antineoplastic medications; and (3) secretion of heparanase from malignant
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of blood is monitored. Self-monitoring and self-management are safe options for competent patients, though their practice varies. In Germany, about 20% of patients were self-managed while only 1% of U.S. patients did home self-testing (according to one 2012 study). Other medications such as
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Ho AF, Zheng H, De Silva DA, Wah W, Earnest A, Pang YH, Xie Z, Pek PP, Liu N (November 2018). "The Relationship Between Ambient Air Pollution and Acute Ischemic Stroke: A Time-Stratified Case-Crossover Study in a City-State With Seasonal Exposure to the Southeast Asian Haze Problem".
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Ho AF, Wah W, Earnest A, Ng YY, Xie Z, Shahidah N, Yap S, Pek PP, Liu N (November 15, 2018). "Health impacts of the Southeast Asian haze problem – A time-stratified case crossover study of the relationship between ambient air pollution and sudden cardiac deaths in Singapore".
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Tran HA, Gibbs H, Merriman E, Curnow JL, Young L, Bennett A, Tan C, Chunilal SD, Ward CM, Baker R, Nandurkar H (March 2019). "New guidelines from the Thrombosis and Haemostasis Society of Australia and New Zealand for the diagnosis and management of venous
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may or may not be ischemic, since veins distribute deoxygenated blood that is less vital for cellular metabolism. Nevertheless, non-ischemic venous thrombosis may still be problematic, due to the swelling caused by blockage to venous drainage. In
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Organisation: following the thrombotic event, residual vascular thrombus will be re-organised histologically with several possible outcomes. For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion),
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plaques. Since blockage of the artery is gradual, the onset of symptomatic thrombotic strokes is slower. Thrombotic stroke can be divided into two categories — large vessel disease or small vessel disease. The former affects vessels such as the
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that can be taken orally to reduce thromboembolic occurrence. Where a more effective response is required, heparin can be given (by injection) concomitantly. As a side effect of any anticoagulant, the risk of bleeding is increased, so the
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occurs when clots then migrate downstream and can affect any organ. Alternatively, arterial occlusion occurs as a consequence of embolism of blood clots originating from the heart ("cardiogenic" emboli). The most common cause is
1719:, which enhances the normal destruction of blood clots by the body's enzymes. This carries an increased risk of bleeding so is generally only used for specific situations (such as severe stroke or a massive pulmonary embolism). 148:
to prevent blood loss. Even when a blood vessel is not injured, blood clots may form in the body under certain conditions. A clot, or a piece of the clot, that breaks free and begins to travel around the body is known as an
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van der Hulle T, den Exter PL, Kooiman J, van der Hoeven JJ, Huisman MV, Klok FA (2014). "Meta-analysis of the efficacy and safety of new oral anticoagulants in patients with cancer-associated acute venous thromboembolism".
4296: 4277: 176:) leads to a blood clot in the affected part of the body, while arterial thrombosis (and, rarely, severe venous thrombosis) affects the blood supply and leads to damage of the tissue supplied by that artery ( 2883:"Time-Stratified Case Crossover Study of the Association of Outdoor Ambient Air Pollution With the Risk of Acute Myocardial Infarction in the Context of Seasonal Exposure to the Southeast Asian Haze Problem" 1516:. For a mural thrombus (defined as a thrombus in a large vessel that restricts the blood flow but does not occlude completely), histological reorganisation of the thrombus does not occur via the classic 1539:
Ischemia/infarction: if an arterial thrombus cannot be lysed by the body and it does not embolise, and if the thrombus is large enough to impair or occlude blood flow in the involved artery, then local
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Dentali F, Douketis JD, Gianni M, Lim W, Crowther MA (February 2007). "Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients".
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Some risk factors predispose for venous thrombosis while others increase the risk of arterial thrombosis. Newborn babies in the neonatal period are also at risk of a thromboembolism.
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by a thrombus. This restriction gives an insufficient supply of oxygen to the heart muscle which then results in tissue death (infarction). A lesion is then formed which is the
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Thrombosis is generally defined by the type of blood vessel affected (arterial or venous thrombosis) and the precise location of the blood vessel or the organ supplied by it.
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thrombosis is a condition that may occur due to infection, intravenous drug use or malignancy. Jugular vein thrombosis can have a varying list of complications, including:
547:, which causes a blood stasis within the atria with easy thrombus formation, but blood clots can develop inside the heart for other reasons too as infective endocarditis. 295:) by a thrombus. The condition usually comes to light after vigorous exercise and usually presents in younger, otherwise healthy people. Men are affected more than women. 1645:(LMWH) administration, mechanical calf compression or (if all else is contraindicated and the patient has recently developed deep vein thrombosis) the insertion of a 5148: 3964:
Bai J, Lyden PD (January 19, 2015). "Revisiting Cerebral Postischemic Reperfusion Injury: New Insights in Understanding Reperfusion Failure, Hemorrhage, and Edema".
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Treatment options for full-term and preterm babies who develop thromboembolism include expectant management (with careful observation), nitroglycerin ointment,
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by a thrombus. Symptoms may include headache, abnormal vision, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body and
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The treatment for thrombosis depends on whether it is in a vein or an artery, the impact on the person, and the risk of complications from treatment.
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Antic D, Milic N, Nikolovski S, Todorovic M, Bila J, Djurdjevic P, Andjelic B, Djurasinovic V, Sretenovic A, Vukovic V, Jelicic J (July 22, 2016).
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infections of the face, for example nasal or upper lip pustules may thus spread directly into the cavernous sinus, causing stroke-like symptoms of
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Min SK, Kim YH, Joh JH, Kang JM, Park UJ, Kim HK, Chang JH, Park SJ, Kim JY, Bae JI, Choi SY, Kim CW, Park SI, Yim NY, Jeon YS (September 2016).
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may cause increased risk of thrombosis by possible activation of the coagulation system by cancer cells or secretion of procoagulant substances (
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Myocardial infarction (MI), or heart attack, is caused by ischemia (restriction in the blood supply), which is often due to the obstruction of a
3288:"A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score" 2008: 1594:
Arterial embolism can lead to obstruction of blood flow through the blood vessel that is obstructed by it, and a lack of oxygen and nutrients (
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Ito T, Kakihana Y, Maruyama I (January 1, 2016). "Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases".
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cells to cover the clot, and this layer of mural smooth muscle will be vascularised by the blood inside the vessel lumen rather than by the
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has issued guidance to the effect that preventative measures should be used in medical patients, in anticipation of formal guidelines.
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heard in 2005 that the annual rate of death due to thrombosis was 25,000, with at least 50% of these being hospital-acquired. Hence
461:. Though characterized by a sharp pain at the site of the vein, it can prove difficult to diagnose, because it can occur at random. 5134: 1587:, finally lodging in and completely obstructing a blood vessel, which unless treated very quickly will lead to tissue necrosis (an 2266:
Mendelson SJ, Prabhakaran S (March 16, 2021). "Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke".
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which may occur in heart failure, or after long periods of sedentary behaviour, such as sitting on a long airplane flight. Also,
1649:. In patients with medical rather than surgical illness, LMWH too is known to prevent thrombosis, and in the United Kingdom the 5265: 3286:
BARBAR S, NOVENTA F, ROSSETTO V, FERRARI A, BRANDOLIN B, PERLATI M, DE BON E, TORMENE D, PAGNAN A, PRANDONI P (November 2010).
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Hughes ES (February 1, 1949). "Venous obstruction in the upper extremity; Paget-Schroetter's syndrome; a review of 320 cases".
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A stroke is the rapid decline of brain function due to a disturbance in the supply of blood to the brain. This can be due to
1409:, which is a key modulator of thrombin activity. The result is a sustained activation of thrombin and reduced production of 4712: 3090: 5440: 5423: 2197: 62:
of the lower right extremity, resulting from acute arterial thrombosis of the right leg (on the left side of the image)
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Hausenloy DJ, Botker HE, Engstrom T, Erlinge D, Heusch G, Ibanez B, Kloner RA, Ovize M, Yellon DM (April 26, 2016).
5502: 5454: 4862: 4479: 4078:"Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations" 3680: 409: 1865:
Handin RI (2005). "Chapter 53: bleeding and thrombosis". In Kasper DL, Braunwald E, Fauci AS, et al. (eds.).
4494: 4355: 1402: 5221: 4813: 1688: 1521: 3585:"Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy" 5508: 5494: 4625: 3445:"Development and validation of multivariable predictive model for thromboembolic events in lymphoma patients" 1431: 200:. An arterial embolus may travel further down the affected blood vessel, where it can lodge as an embolism. 5482: 5445: 5315: 4930: 4850: 4555: 1771: 1716: 1642: 280: 2054: 1982: 1602:. This can affect any organ; for instance, arterial embolism of the brain is one of the causes of stroke. 5635: 5211: 4945: 4940: 4667: 4657: 4244: 3681:"Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data" 1638: 1175: 902: 196:. Complications can arise when a venous thromboembolism (commonly called a VTE) lodges in the lung as a 5590: 5435: 5046: 4697: 4672: 4489: 4418: 4348: 1810: 1227: 475: 470: 431: 17: 5706: 5277: 5258: 5071: 5014: 4662: 4615: 4465: 4428: 1805: 1693: 1646: 1084: 647: 494:
ophthalmic veins of the orbit, which drain directly posteriorly into the cavernous sinus through the
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of the basal skull dura, due to the retrograde spread of infection and endothelial damage from the
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tissue, where the scar tissue will either permanently obstruct the vessel, or contract down with
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Ho AF, Zheng H, Earnest A, Cheong KH, Pek PP, Seok JY, Liu N, Kwan YH, Tan JW (March 19, 2019).
1629:(prevention of thrombosis) is increasingly emphasized. In patients admitted for surgery, graded 681:" has been suggested to describe the three factors necessary for the formation of thrombosis: 5580: 5555: 5513: 5083: 5066: 5061: 5051: 4892: 4828: 4470: 4371: 3635: 2239: 2020: 1558: 345: 102: 2745: 5575: 5565: 5383: 5088: 4833: 4692: 4684: 4652: 4539: 2111: 1892:"Diagnosis and Treatment of Lower Extremity Deep Vein Thrombosis: Korean Practice Guidelines" 1679: 1630: 1611: 1449: 1440:
Causes of disturbed blood flow include stagnation of blood flow past the point of injury, or
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is a specialised form of cerebral venous sinus thrombosis, where there is thrombosis of the
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Mechanical clot retrieval and catheter-guided thrombolysis are used in certain situations.
1598:) of the downstream tissue. The tissue can become irreversibly damaged, a process known as 1554: 1394: 1138: 419: 304: 248:
Three factors are important in the formation of a blood clot within a deep vein—these are:
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Clinical guideline 92: Venous thromboembolism: reducing the risk for patients in hospital
3386:"Development and validation of a predictive model for chemotherapy-associated thrombosis" 1728: 1697: 1445: 1109: 826: 815: 636: 544: 427: 351: 169: 3335:
Khorana AA, Francis CW, Culakova E, Fisher RI, Kuderer NM, Lyman GH (January 20, 2006).
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in endothelium producing to a pro-thrombotic state. When this occurs, endothelial cells
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Any inflammatory process, such as trauma, surgery or infection, can cause damage to the
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This article was last reviewed on May 23, 2007, and was last modified on March 6, 2010.
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Faria AV, Andrade SS, Peppelenbosch MP, Ferreira-Halder CV, Fuhler GM (December 2020).
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Romantsik O, Bruschettini M, Zappettini S, Ramenghi LA, Calevo MG (November 7, 2016).
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Arterial thrombosis is platelet-rich, and inhibition of platelet aggregation with
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Thrombosis prevention is initiated with assessing the risk for its development.
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An arterial thrombus or embolus can also form in the limbs, which can lead to
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Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW (May 15, 2008).
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to the blood coagulation system. Inflammatory and other stimuli (such as
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Creager MA, Kaufman JA, Conte MS (June 7, 2012). "Acute Limb Ischemia".
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are widely used, and in severe illness, prolonged immobility and in all
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and tissue factor inhibitor, which furthers the pro-thrombotic state.
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is the pharmacological destruction of blood clots by administering
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In thrombotic stroke, a thrombus (blood clot) usually forms around
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is the physiological breakdown of blood clots by enzymes such as
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of the face. The facial veins in this area anastomose with the
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by a thrombus. This tends to lead to reduced drainage from the
362:. It usually happens in the setting of another disease such as 165: 141: 133: 4075: 2158:"Causes and predictors of death in cerebral venous thrombosis" 1830:
Furie B, Furie BC (2008). "Mechanisms of thrombus formation".
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Brunner & Suddarth's textbook of medical-surgical nursing
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Arterial thrombosis is the formation of a thrombus within an
434:. The majority of persons affected make a full recovery. The 359: 121: 3583:
Geerts WH, Pineo GF, Heit JA, et al. (September 2004).
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CanhĂŁo P, Ferro JM, Lindgren AG, et al. (August 2005).
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A thrombus may become detached and enter circulation as an
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of developing thrombosis and its possible development into
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impairment, which if severe enough can lead to blindness.
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Cerebral venous sinus thrombosis (CVST) is a rare form of
2132:"Renal vein thrombosis: MedlinePlus Medical Encyclopedia" 1436:
tumors that results in degradation of endogenous heparin.
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Clinical guideline 46: Venous thromboembolism (surgical)
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Vaughan DE (August 2005). "PAI-1 and atherothrombosis".
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will reorganise the occlusive thrombus into collagenous
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of the vessel's wall. The main mechanism is exposure of
530:. In most cases, arterial thrombosis follows rupture of 283:
or upper extremity DVT (UEDVT) is the obstruction of an
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Deep vein thrombosis (DVT) is the formation of a blood
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Ovarian hyper-stimulation therapy to treat infertility
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Grace PA (May 1994). "Ischaemia-reperfusion injury".
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National Institute for Health and Clinical Excellence
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National Institute for Health and Clinical Excellence
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Webster GJ, Burroughs AK, Riordan SM (January 2005).
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Arterial thrombosis may require surgery if it causes
4370: 4259: 2992:"Platelets in aging and cancer-"double-edged sword"" 2880: 2588: 2445: 2265: 1448:, causes stagnant blood in the left atrium (LA), or 3139: 2712: 2550: 2316: 650:usually occurs as a devastating complication after 403: 3678: 2828: 2803: 2646: 2467: 2389: 2354: 2240:MDGuidelines > Arterial Embolism And Thrombosis 1755:may reduce the risk of recurrence or progression. 1557:this manifests as pain, redness, and swelling; in 241:. It most commonly affects leg veins, such as the 4018:Ho AF, Jun C, Ong ME, Hausenloy DJ (April 2019). 4017: 3086: 3084: 3082: 3080: 3078: 1700:are increasingly being used instead of warfarin. 27:Formation of blood clots inside the blood vessels 5755: 3862: 3860: 3190: 2629: 2627: 2253:by Presley Reed, MD. Retrieved on April 30, 2010 392:Renal vein thrombosis is the obstruction of the 3917: 3582: 3117:Robbins and Cotran Pathologic Basis of Disease 3075: 2937: 5142: 4356: 3857: 3091:labtestsonline > Hypercoagulable Disorders 2624: 1889: 464: 4198:. Chichester, West Sussex: Wiley-Blackwell. 3119:. Philadelphia: Elsevier. pp. 122–130. 2760: 2355:Bekker J, Ploem S, de Jong KP (April 2009). 2116:: CS1 maint: multiple names: authors list ( 670:. Some of these risk factors are related to 172:). Venous thrombosis (sometimes called DVT, 3040: 2506:The Cochrane Database of Systematic Reviews 2068:DeLeve LD, Valla DC, Garcia-Tsao G (2009). 1335:The main causes of thrombosis are given in 1276:Post-menopausal hormone replacement therapy 269: 5149: 5135: 4936:Chronic cerebrospinal venous insufficiency 4363: 4349: 3191:Nasser NJ, Fox J, Agbarya A (March 2020). 2013:Alimentary Pharmacology & Therapeutics 1867:Harrison's Principles of Internal Medicine 1829: 1380: 514:, as well as spread of infection to cause 441: 50: 4193: 4109: 3807: 3749: 3699: 3639: 3538: 3460: 3419: 3401: 3352: 3303: 3218: 3208: 3058: 3017: 3007: 2914: 2887:Journal of the American Heart Association 2533: 2372: 2173: 2093: 2024: 1923: 1864: 1734: 565:Acute thrombus in the right MCA M1 branch 358:and reduction of the blood supply to the 339: 266:, pain and redness of the affected area. 4155: 3963: 3672: 2616:sfn error: no target: CITEREFMoliterno ( 2459:sfn error: no target: CITEREFMoliterno ( 1869:(16th ed.). New York: McGraw-Hill. 1717:recombinant tissue plasminogen activator 1430: 604: 560: 381: 320:. This form of thrombosis presents with 112: 'clotting') is the formation of a 5403: 4174: 4136: 4013: 4011: 3650:10.7326/0003-4819-146-4-200702200-00007 3578: 3576: 3520: 3516: 3514: 2766: 2730:sfn error: no target: CITEREFCopstead ( 2580:sfn error: no target: CITEREFCopstead ( 2224:"Guidelines Cavernous sinus thrombosis" 1420: 426:. The diagnosis is usually made with a 418:which results from the blockage of the 298: 222: 14: 5756: 3043:"The role of leukocytes in thrombosis" 2814:sfn error: no target: CITEREFBrunner ( 2704:sfn error: no target: CITEREFBrunner ( 2478:sfn error: no target: CITEREFBrunner ( 2437:sfn error: no target: CITEREFHoffman ( 2261: 2259: 2000: 1946: 1801:Disseminated intravascular coagulation 1777: 1742: 1311:thought to be related to inflammation 1197:Selective estrogen-receptor modulators 521: 192:. This type of embolism is known as a 5130: 4708:Hereditary hemorrhagic telangiectasia 4344: 4212: 3866: 3840:"Aspirin Monograph for Professionals" 3679:Heneghan C, Ward A, Perera R (2012). 3292:Journal of Thrombosis and Haemostasis 3142:Expert Opinion on Therapeutic Targets 3114: 3110: 3108: 3106: 3041:Swystun LL, Liaw PC (June 27, 2016). 2769:Journal of Thrombosis and Haemostasis 2611: 2495: 2493: 2491: 2489: 2454: 2149: 1759:Targeting ischemia/reperfusion injury 1354: 956:Local vein damage, incompetent valves 749:slow flow is modifiable with exercise 203: 4713:Generalized essential telangiectasia 4008: 3573: 3511: 2725: 2638:sfn error: no target: CITEREFAbele ( 2575: 1949:Surgery, Gynecology & Obstetrics 1256:Paroxysmal nocturnal hemoglobinnuria 1128:inhibits physiological breakdown of 849:Pregnancy and the post-partum period 211: 2941:International Journal of Cardiology 2809: 2699: 2473: 2432: 2361:American Journal of Transplantation 2256: 350:Portal vein thrombosis affects the 24: 4196:Therapeutic advances in thrombosis 3103: 2486: 2175:10.1161/01.STR.0000173152.84438.1c 1664: 1484: 1479: 1085:Antiphospholipid antibody syndrome 25: 5775: 4232: 4179:. New York: McGraw-Hill Medical. 2844:10.1016/j.annemergmed.2018.06.037 2633: 2070:"Vascular disorders of the liver" 1896:Vascular Specialist International 5503:platelet storage pool deficiency 5455:Heparin-induced thrombocytopenia 4863:Cerebral venous sinus thrombosis 4238: 3730:The Medical Journal of Australia 3527:Arterioscler. Thromb. Vasc. Biol 3305:10.1111/j.1538-7836.2010.04044.x 2781:10.1111/j.1538-7836.2005.01420.x 2374:10.1111/j.1600-6143.2008.02541.x 2035:10.1111/j.1365-2036.2004.02301.x 630: 410:Cerebral venous sinus thrombosis 404:Cerebral venous sinus thrombosis 4130: 4069: 3966:International Journal of Stroke 3957: 3923:New England Journal of Medicine 3911: 3832: 3788:New England Journal of Medicine 3774: 3716: 3619: 3555: 3493: 3436: 3377: 3328: 3279: 3235: 3184: 3133: 3034: 2983: 2931: 2874: 2822: 2738: 2348: 2319:New England Journal of Medicine 2310: 2233: 2216: 2190: 1832:New England Journal of Medicine 1703: 1572: 1324: 927:by abnormality, tumor, hematoma 726:Previous episodes of thrombosis 262:Classical signs of DVT include 5222:Activated protein C resistance 4814:Hepatic veno-occlusive disease 3869:The British Journal of Surgery 3601:10.1378/chest.126.3_suppl.338S 3449:American Journal of Hematology 2518:10.1002/14651858.CD012185.pub2 2251:The Medical Disability Advisor 2124: 2061: 1975: 1940: 1883: 1858: 1823: 1689:international normalized ratio 1522:platelet-derived growth factor 664:Some people have a higher risk 642: 316:or of the hepatic part of the 255:the thickness of the blood and 13: 1: 4626:Aneurysm of sinus of Valsalva 4480:Monckeberg's arteriosclerosis 3701:10.1016/S0140-6736(11)61294-4 3154:10.1517/14728222.2016.1086750 2996:Cancer and Metastasis Reviews 1816: 1605: 1369:, is caused by, for example, 1298:when a thrombus forms, it is 1295:Venous inflammation/phlebitis 688:(blood stasis or turbulence), 258:qualities of the vessel wall. 5316:Trousseau sign of malignancy 4931:Chronic venous insufficiency 4556:Aortoiliac occlusive disease 4215:Atlas of gynecologic surgery 4039:10.1097/SHK.0000000000001362 3403:10.1182/blood-2007-10-116327 3341:Journal of Clinical Oncology 3060:10.1182/blood-2016-05-718114 2953:10.1016/j.ijcard.2018.04.070 2832:Annals of Emergency Medicine 1772:remote ischemic conditioning 1656: 1643:low molecular weight heparin 1524:degranulated by the clotted 1319: 1279:discontinuation reduces risk 1247:Myeloproliferative disorders 1074:congenital; associated with 907:discontinuation reduces risk 895:discontinuation reduces risk 746:Slow or turbulent blood flow 710:Risk factors for thrombosis 136:) is injured, the body uses 7: 5636:Nonthrombocytopenic purpura 5212:Antithrombin III deficiency 4946:Inferior vena cava syndrome 4941:Superior vena cava syndrome 4668:Vertebral artery dissection 4658:Intracranial berry aneurysm 4160:. St. Louis, Mo: Elsevier. 1789: 1176:Antithrombin III deficiency 903:Hormone replacement therapy 698:altered blood coagulation ( 354:, which can lead to portal 10: 5780: 5591:Congenital afibrinogenemia 5495:Glanzmann's thrombasthenia 5047:Hypertensive heart disease 4698:Arteriovenous malformation 4673:Familial aortic dissection 3540:10.1161/ATVBAHA.108.162586 3009:10.1007/s10555-020-09926-2 1811:Thrombotic microangiopathy 1762: 1722: 1694:direct thrombin inhibitors 1668: 1609: 1576: 1424: 1358: 1328: 1228:Inflammatory bowel disease 608: 554: 476:Cavernous sinus thrombosis 471:Cavernous sinus thrombosis 468: 465:Cavernous sinus thrombosis 407: 385: 343: 302: 273: 226: 215: 120:, obstructing the flow of 31: 5707:Gastrointestinal bleeding 5646: 5603: 5524: 5509:Hermansky–Pudlak syndrome 5468: 5410: 5396: 5324: 5286: 5278:Antiphospholipid syndrome 5259:Essential thrombocythemia 5199: 5192: 5169: 5102: 5072:Renovascular hypertension 5037: 5028: 5015:Hepatic artery thrombosis 4963: 4923: 4878: 4782: 4764: 4755: 4723: 4683: 4663:Carotid artery dissection 4616:Abdominal aortic aneurysm 4588: 4548: 4525: 4466:Intermittent claudication 4436: 4429:Peripheral artery disease 4427: 4397: 4379: 4263: 2245:February 2, 2018, at the 1987:National Cancer Institute 1806:Hepatic artery thrombosis 1452:(LAA), and can lead to a 1397:) can lead to changes in 923:Compression of a vein or 806:Acute respiratory failure 695:) injury/dysfunction, and 657: 648:Hepatic artery thrombosis 550: 128:. When a blood vessel (a 86: 66: 58: 49: 44: 5677:Subconjunctival bleeding 5483:Bernard–Soulier syndrome 5446:Upshaw–Schulman syndrome 5420:Thrombocytopenic purpura 5249:Sticky platelet syndrome 5057:Hypertensive nephropathy 4870:Post-thrombotic syndrome 4851:Paget–Schroetter disease 4643:Coronary artery aneurysm 4621:Thoracic aortic aneurysm 4094:10.1093/eurheartj/ehw145 3354:10.1200/jco.2005.03.8877 1908:10.5758/vsi.2016.32.3.77 1528:will attract a layer of 1520:mechanism. Instead, the 1512:activity to unblock the 991:Repetitive motion injury 966:Central venous catheters 496:superior orbital fissure 281:Paget-Schroetter disease 276:Paget-Schroetter disease 270:Paget-Schroetter disease 156:Thrombosis may occur in 5667:Intracranial hemorrhage 5112:Orthostatic hypotension 5094:White coat hypertension 4571:Fibromuscular dysplasia 4535:Carotid artery stenosis 3508:. London, January 2010. 3210:10.3390/cancers12030566 2899:10.1161/JAHA.118.011272 2344:(subscription required) 2280:10.1001/jama.2020.26867 1784:pharmacological therapy 1639:professional guidelines 1623:Health Select Committee 1470:paraneoplastic syndrome 1381:Endothelial cell injury 577:(a lodged particle) or 442:Jugular vein thrombosis 252:the rate of blood flow, 5581:Factor XIII deficiency 5561:Hypoprothrombinemia/II 5556:von Willebrand disease 5514:Gray platelet syndrome 5084:Pulmonary hypertension 5067:Secondary hypertension 5062:Essential hypertension 5052:Hypertensive emergency 4893:Portacaval anastomosis 4829:Portal vein thrombosis 4471:Critical limb ischemia 4372:Cardiovascular disease 4082:European Heart Journal 3881:10.1002/bjs.1800810504 3595:(3 Suppl): 338S–400S. 3521:Hunt BJ (March 2008). 3096:June 18, 2007, at the 1735:Endovascular treatment 1559:retinal vein occlusion 1437: 1365:Hypercoagulability or 1347:injury, and disturbed 1308:Ambient air pollution 1187:Falls and hip fracture 566: 346:Portal vein thrombosis 340:Portal vein thrombosis 5576:Factor XII deficiency 5566:Factor VII deficiency 5384:Renal vein thrombosis 5089:Systolic hypertension 4834:Renal vein thrombosis 4693:Arteriovenous fistula 4685:Vascular malformation 4653:Intracranial aneurysm 4540:Renal artery stenosis 4217:. Stuttgart: Thieme. 3800:10.1056/NEJMoa1411587 3570:. London, April 2007. 2748:. The Free Dictionary 2331:10.1056/NEJMcp1006054 2057:on December 10, 2012. 1844:10.1056/NEJMra0801082 1680:vitamin K antagonists 1651:Chief Medical Officer 1631:compression stockings 1612:Thrombosis prevention 1577:Further information: 1450:left atrial appendage 1434: 1425:Further information: 1218:Acute medical illness 1190:related to immobility 652:liver transplantation 611:Myocardial infarction 605:Myocardial infarction 564: 388:Renal vein thrombosis 382:Renal vein thrombosis 312:is the blockage of a 92:Dependent on location 32:For the journal, see 5332:Deep vein thrombosis 5227:Protein S deficiency 5217:Protein C deficiency 5003:Paradoxical embolism 4998:Cholesterol embolism 4824:May–Thurner syndrome 4819:Budd–Chiari syndrome 4802:Deep vein thrombosis 4797:primarily lower limb 4576:Raynaud's phenomenon 4247:at Wikimedia Commons 4194:Moliterno D (2013). 3935:10.1056/nejmra071667 3615:on October 11, 2004. 1796:Blood clotting tests 1698:direct Xa inhibitors 1555:deep vein thrombosis 1421:Disturbed blood flow 1395:hypercholesterolemia 1375:autoimmune disorders 1371:genetic deficiencies 1139:Hyperhomocysteinemia 774:Sedentary life style 625:thrombolytic therapy 420:dural venous sinuses 310:Budd-Chiari syndrome 305:Budd-Chiari syndrome 299:Budd-Chiari syndrome 229:Deep vein thrombosis 223:Deep vein thrombosis 174:deep vein thrombosis 34:Thrombosis (journal) 5571:Factor X deficiency 5460:May–Hegglin anomaly 5237:Prothrombin G20210A 5079:Benign hypertension 4177:Williams gynecology 4156:Copstead L (2013). 1778:Neonatal thrombosis 1743:Antiplatelet agents 1729:acute limb ischemia 1561:this may result in 1446:atrial fibrillation 1405:substances such as 1286:Right heart failure 1209:-stimulating agents 1180:altered coagulation 1168:altered coagulation 1143:altered coagulation 1115:altered coagulation 1110:Prothrombin G20210A 1102:altered coagulation 1089:altered coagulation 711: 686:hemodynamic changes 637:acute limb ischemia 545:atrial fibrillation 522:Arterial thrombosis 352:hepatic portal vein 170:arterial thrombosis 140:(thrombocytes) and 5697:Pulmonary hematoma 5604:Signs and symptoms 5379:Pulmonary embolism 5184:Bleeding diathesis 4993:Pulmonary embolism 4903:Esophageal varices 4841:upper limb / torso 4485:Arteriolosclerosis 4175:Hoffman B (2012). 4137:Brunner L (2010). 3742:10.5694/mja2.50004 1765:Reperfusion injury 1749:antiplatelet drugs 1713:thrombolytic drugs 1635:orthopedic surgery 1627:thromboprophylaxis 1621:the Parliamentary 1438: 1387:endothelial lining 1355:Hypercoagulability 1238:Nephrotic syndrome 1012:Spinal cord injury 891:oral contraceptive 709: 700:hypercoagulability 567: 455:pulmonary embolism 376:cholangiocarcinoma 318:inferior vena cava 287:vein (such as the 204:Signs and symptoms 198:pulmonary embolism 126:circulatory system 5751: 5750: 5747: 5746: 5599: 5598: 5586:Dysfibrinogenemia 5470:Platelet function 5392: 5391: 5271:Purpura fulminans 5124: 5123: 5120: 5119: 4964:Arteries or veins 4959: 4958: 4784:Venous thrombosis 4751: 4750: 4733:Cherry hemangioma 4633:Aortic dissection 4584: 4583: 4419:Buerger's disease 4338: 4337: 4243:Media related to 4224:978-3-13-650704-9 4205:978-1-4051-9625-3 4186:978-0-07-171672-7 4167:978-1-4557-2650-9 4148:978-0-7817-8590-7 3978:10.1111/ijs.12434 3929:(11): 1121–1135. 3694:(9813): 322–334. 3462:10.1002/ajh.24466 3455:(10): 1014–1019. 3396:(10): 4902–4907. 3298:(11): 2450–2457. 3257:10.1111/jth.12605 3126:978-1-4557-2613-4 2325:(23): 2198–2206. 2274:(11): 1088–1098. 2204:on April 14, 2021 2086:10.1002/hep.22772 1876:978-0-07-139140-5 1317: 1316: 1076:Warfarin necrosis 591:internal carotids 540:Arterial embolism 218:Venous thrombosis 212:Venous thrombosis 162:venous thrombosis 96: 95: 77:internal medicine 39:Medical condition 16:(Redirected from 5771: 5412:Thrombocytopenia 5408: 5407: 5401: 5400: 5357:Lowenberg's sign 5207:Clotting factors 5197: 5196: 5151: 5144: 5137: 5128: 5127: 5035: 5034: 4846:Mondor's disease 4789:Thrombophlebitis 4762: 4761: 4438:Arteriosclerosis 4434: 4433: 4395: 4394: 4365: 4358: 4351: 4342: 4341: 4261: 4260: 4242: 4228: 4213:Abele H (2014). 4209: 4190: 4171: 4152: 4124: 4123: 4113: 4073: 4067: 4066: 4024: 4015: 4006: 4005: 3961: 3955: 3954: 3915: 3909: 3908: 3864: 3855: 3854: 3852: 3850: 3836: 3830: 3829: 3811: 3778: 3772: 3771: 3753: 3720: 3714: 3713: 3703: 3685: 3676: 3670: 3669: 3643: 3628:Ann. Intern. Med 3623: 3617: 3616: 3611:. Archived from 3580: 3571: 3559: 3553: 3552: 3542: 3518: 3509: 3497: 3491: 3490: 3464: 3440: 3434: 3433: 3423: 3405: 3381: 3375: 3374: 3356: 3332: 3326: 3325: 3307: 3283: 3277: 3276: 3245:J Thromb Haemost 3239: 3233: 3232: 3222: 3212: 3188: 3182: 3181: 3137: 3131: 3130: 3115:Kumar V (2015). 3112: 3101: 3088: 3073: 3072: 3062: 3038: 3032: 3031: 3021: 3011: 3002:(4): 1205–1221. 2987: 2981: 2980: 2935: 2929: 2928: 2918: 2878: 2872: 2871: 2826: 2820: 2819: 2807: 2801: 2800: 2764: 2758: 2757: 2755: 2753: 2742: 2736: 2735: 2723: 2710: 2709: 2697: 2644: 2643: 2631: 2622: 2621: 2609: 2586: 2585: 2573: 2548: 2547: 2537: 2512:(11): CD012185. 2497: 2484: 2483: 2471: 2465: 2464: 2452: 2443: 2442: 2430: 2387: 2386: 2376: 2352: 2346: 2345: 2342: 2314: 2308: 2307: 2263: 2254: 2237: 2231: 2230: 2228: 2220: 2214: 2213: 2211: 2209: 2200:. Archived from 2194: 2188: 2187: 2177: 2168:(8): 1720–1725. 2153: 2147: 2146: 2144: 2142: 2128: 2122: 2121: 2115: 2107: 2097: 2065: 2059: 2058: 2053:. Archived from 2028: 2004: 1998: 1997: 1995: 1993: 1979: 1973: 1972: 1944: 1938: 1937: 1927: 1887: 1881: 1880: 1862: 1856: 1855: 1827: 1647:vena cava filter 1345:endothelial cell 1300:thrombophlebitis 736:Vasoconstriction 712: 708: 599:circle of Willis 536:atherothrombosis 73:Vascular surgery 54: 42: 41: 21: 5779: 5778: 5774: 5773: 5772: 5770: 5769: 5768: 5754: 5753: 5752: 5743: 5692:Hemopericardium 5642: 5595: 5526:Clotting factor 5520: 5464: 5388: 5337:Bancroft's sign 5320: 5311:Virchow's triad 5282: 5232:Factor V Leiden 5188: 5165: 5155: 5125: 5116: 5098: 5024: 4981:Microangiopathy 4976:Macroangiopathy 4955: 4919: 4888:Gastric varices 4874: 4787: 4778: 4747: 4719: 4679: 4611:Aortic aneurysm 4597: 4580: 4566:Erythromelalgia 4544: 4521: 4446:Atherosclerosis 4423: 4387: 4375: 4369: 4339: 4334: 4333: 4272: 4235: 4225: 4206: 4187: 4168: 4158:Pathophysiology 4149: 4133: 4128: 4127: 4088:(13): 935–941. 4074: 4070: 4022: 4016: 4009: 3962: 3958: 3916: 3912: 3865: 3858: 3848: 3846: 3838: 3837: 3833: 3779: 3775: 3726:thromboembolism 3721: 3717: 3683: 3677: 3673: 3641:10.1.1.694.4563 3624: 3620: 3581: 3574: 3560: 3556: 3519: 3512: 3498: 3494: 3441: 3437: 3382: 3378: 3333: 3329: 3284: 3280: 3240: 3236: 3189: 3185: 3138: 3134: 3127: 3113: 3104: 3098:Wayback Machine 3089: 3076: 3039: 3035: 2988: 2984: 2936: 2932: 2879: 2875: 2827: 2823: 2813: 2808: 2804: 2765: 2761: 2751: 2749: 2744: 2743: 2739: 2729: 2724: 2713: 2703: 2698: 2647: 2637: 2632: 2625: 2615: 2610: 2589: 2579: 2574: 2551: 2498: 2487: 2477: 2472: 2468: 2458: 2453: 2446: 2436: 2431: 2390: 2353: 2349: 2343: 2315: 2311: 2264: 2257: 2247:Wayback Machine 2238: 2234: 2226: 2222: 2221: 2217: 2207: 2205: 2196: 2195: 2191: 2154: 2150: 2140: 2138: 2136:medlineplus.gov 2130: 2129: 2125: 2109: 2108: 2066: 2062: 2026:10.1.1.536.2660 2005: 2001: 1991: 1989: 1981: 1980: 1976: 1945: 1941: 1888: 1884: 1877: 1863: 1859: 1828: 1824: 1819: 1792: 1780: 1767: 1761: 1745: 1737: 1725: 1706: 1673: 1667: 1665:Anticoagulation 1659: 1614: 1608: 1581: 1575: 1550:venous thrombus 1548:will result. A 1510:myofibroblastic 1487: 1485:Natural history 1482: 1480:Pathophysiology 1454:thromboembolism 1429: 1423: 1399:gene expression 1383: 1363: 1357: 1337:Virchow's triad 1333: 1331:Virchow's triad 1327: 1322: 1097:Factor V Leiden 1004:modifiable risk 889:Estrogen-based 679:Virchow's triad 668:thromboembolism 660: 645: 633: 617:coronary artery 613: 607: 586:atherosclerotic 559: 553: 524: 484:danger triangle 480:cavernous sinus 473: 467: 451:systemic sepsis 444: 412: 406: 390: 384: 348: 342: 307: 301: 293:subclavian vein 278: 272: 231: 225: 220: 214: 206: 194:thromboembolism 40: 37: 28: 23: 22: 15: 12: 11: 5: 5777: 5767: 5766: 5749: 5748: 5745: 5744: 5742: 5741: 5740: 5739: 5731: 5730: 5729: 5724: 5719: 5717:Hemoperitoneum 5714: 5709: 5701: 5700: 5699: 5694: 5689: 5681: 5680: 5679: 5674: 5669: 5664: 5659: 5650: 5648: 5644: 5643: 5641: 5640: 5639: 5638: 5628: 5623: 5618: 5613: 5607: 5605: 5601: 5600: 5597: 5596: 5594: 5593: 5588: 5583: 5578: 5573: 5568: 5563: 5558: 5553: 5552: 5551: 5546: 5541: 5530: 5528: 5522: 5521: 5519: 5518: 5517: 5516: 5511: 5499: 5498: 5497: 5487: 5486: 5485: 5474: 5472: 5466: 5465: 5463: 5462: 5457: 5451: 5450: 5449: 5448: 5443: 5433: 5432: 5431: 5429:Evans syndrome 5416: 5414: 5405: 5398: 5394: 5393: 5390: 5389: 5387: 5386: 5381: 5376: 5375: 5374: 5369: 5364: 5362:Peabody's sign 5359: 5354: 5349: 5344: 5339: 5328: 5326: 5322: 5321: 5319: 5318: 5313: 5308: 5303: 5298: 5292: 5290: 5284: 5283: 5281: 5280: 5275: 5274: 5273: 5263: 5262: 5261: 5256: 5254:Thrombocytosis 5251: 5241: 5240: 5239: 5234: 5229: 5224: 5219: 5214: 5203: 5201: 5194: 5190: 5189: 5187: 5186: 5181: 5176: 5170: 5167: 5166: 5154: 5153: 5146: 5139: 5131: 5122: 5121: 5118: 5117: 5115: 5114: 5108: 5106: 5100: 5099: 5097: 5096: 5091: 5086: 5081: 5076: 5075: 5074: 5064: 5059: 5054: 5049: 5043: 5041: 5032: 5030:Blood pressure 5026: 5025: 5023: 5022: 5017: 5012: 5007: 5006: 5005: 5000: 4995: 4985: 4984: 4983: 4978: 4967: 4965: 4961: 4960: 4957: 4956: 4954: 4953: 4948: 4943: 4938: 4933: 4927: 4925: 4921: 4920: 4918: 4917: 4912: 4911: 4910: 4905: 4900: 4890: 4884: 4882: 4880:Varicose veins 4876: 4875: 4873: 4872: 4867: 4866: 4865: 4855: 4854: 4853: 4848: 4838: 4837: 4836: 4831: 4826: 4821: 4816: 4806: 4805: 4804: 4793: 4791: 4780: 4779: 4777: 4776: 4770: 4768: 4759: 4753: 4752: 4749: 4748: 4746: 4745: 4743:Spider angioma 4740: 4735: 4729: 4727: 4725:Vascular nevus 4721: 4720: 4718: 4717: 4716: 4715: 4710: 4703:Telangiectasia 4700: 4695: 4689: 4687: 4681: 4680: 4678: 4677: 4676: 4675: 4670: 4665: 4660: 4655: 4645: 4640: 4638:Aortic rupture 4635: 4630: 4629: 4628: 4623: 4618: 4603: 4601: 4599:pseudoaneurysm 4586: 4585: 4582: 4581: 4579: 4578: 4573: 4568: 4563: 4558: 4552: 4550: 4546: 4545: 4543: 4542: 4537: 4531: 4529: 4523: 4522: 4520: 4519: 4518: 4517: 4512: 4510:Oxycholesterol 4507: 4502: 4497: 4492: 4482: 4476: 4475: 4474: 4473: 4468: 4463: 4458: 4453: 4442: 4440: 4431: 4425: 4424: 4422: 4421: 4416: 4415: 4414: 4403: 4401: 4392: 4377: 4376: 4368: 4367: 4360: 4353: 4345: 4336: 4335: 4332: 4331: 4320: 4293: 4273: 4268: 4267: 4265: 4264:Classification 4258: 4257: 4248: 4234: 4233:External links 4231: 4230: 4229: 4223: 4210: 4204: 4191: 4185: 4172: 4166: 4153: 4147: 4132: 4129: 4126: 4125: 4068: 4033:(3): 269–276. 4007: 3972:(2): 143–152. 3956: 3910: 3875:(5): 637–647. 3856: 3831: 3773: 3736:(5): 227–235. 3715: 3671: 3618: 3572: 3554: 3510: 3492: 3435: 3376: 3347:(3): 484–490. 3327: 3278: 3251:(7): 1116–20. 3234: 3183: 3148:(2): 151–158. 3132: 3125: 3102: 3074: 3053:(6): 753–762. 3033: 2982: 2930: 2893:(6): e011272. 2873: 2838:(5): 591–601. 2821: 2812:, p. 876. 2802: 2775:(8): 1879–83. 2759: 2737: 2728:, p. 329. 2711: 2702:, p. 875. 2645: 2623: 2614:, p. 307. 2587: 2578:, p. 320. 2549: 2485: 2476:, p. 874. 2466: 2457:, p. 306. 2444: 2435:, p. 960. 2388: 2367:(4): 746–757. 2347: 2309: 2255: 2232: 2215: 2189: 2148: 2123: 2080:(5): 1729–64. 2060: 1999: 1974: 1939: 1882: 1875: 1857: 1838:(9): 938–949. 1821: 1820: 1818: 1815: 1814: 1813: 1808: 1803: 1798: 1791: 1788: 1779: 1776: 1763:Main article: 1760: 1757: 1744: 1741: 1736: 1733: 1724: 1721: 1705: 1702: 1684:anticoagulants 1669:Main article: 1666: 1663: 1658: 1655: 1610:Main article: 1607: 1604: 1574: 1571: 1563:macular oedema 1486: 1483: 1481: 1478: 1422: 1419: 1407:thrombomodulin 1382: 1379: 1359:Main article: 1356: 1353: 1329:Main article: 1326: 1323: 1321: 1318: 1315: 1314: 1312: 1309: 1305: 1304: 1302: 1296: 1292: 1291: 1289: 1287: 1283: 1282: 1280: 1277: 1273: 1272: 1270: 1268: 1266:Thrombophilias 1262: 1261: 1259: 1257: 1253: 1252: 1250: 1248: 1244: 1243: 1241: 1239: 1235: 1234: 1232: 1230: 1224: 1223: 1221: 1219: 1215: 1214: 1212: 1210: 1207:Erythropoiesis 1203: 1202: 1200: 1198: 1194: 1193: 1191: 1188: 1184: 1183: 1181: 1178: 1172: 1171: 1169: 1166: 1147: 1146: 1144: 1141: 1135: 1134: 1132: 1126: 1119: 1118: 1116: 1113: 1106: 1105: 1103: 1100: 1093: 1092: 1090: 1087: 1081: 1080: 1078: 1072: 1061: 1060: 1058: 1056: 1050: 1049: 1047: 1045: 1039: 1038: 1036: 1034: 1028: 1027: 1025: 1023: 1019: 1018: 1016: 1014: 1008: 1007: 1005: 1002: 998: 997: 995: 993: 987: 986: 984: 982: 973: 972: 970: 968: 962: 961: 959: 957: 953: 952: 950: 948: 942: 941: 939: 937: 936:Long surgeries 933: 932: 930: 928: 920: 919: 917: 915: 911: 910: 908: 905: 899: 898: 896: 893: 886: 885: 883: 881: 875: 874: 872: 870: 866: 865: 863: 861: 859:Varicose veins 855: 854: 852: 850: 846: 845: 843: 840: 834: 833: 831: 829: 823: 822: 820: 818: 812: 811: 809: 807: 803: 802: 800: 797: 791: 790: 788: 785: 781: 780: 778: 775: 771: 770: 768: 766: 762: 761: 759: 757: 753: 752: 750: 747: 743: 742: 740: 738: 732: 731: 729: 727: 723: 722: 719: 716: 704: 703: 696: 689: 659: 656: 644: 641: 632: 629: 627:is initiated. 609:Main article: 606: 603: 555:Main article: 552: 549: 523: 520: 469:Main article: 466: 463: 443: 440: 436:mortality rate 408:Main article: 405: 402: 386:Main article: 383: 380: 372:diverticulitis 344:Main article: 341: 338: 330:enlarged liver 322:abdominal pain 303:Main article: 300: 297: 274:Main article: 271: 268: 260: 259: 256: 253: 227:Main article: 224: 221: 216:Main article: 213: 210: 205: 202: 94: 93: 90: 84: 83: 70: 64: 63: 56: 55: 47: 46: 38: 26: 9: 6: 4: 3: 2: 5776: 5765: 5762: 5761: 5759: 5738: 5735: 5734: 5732: 5728: 5727:Hematosalpinx 5725: 5723: 5720: 5718: 5715: 5713: 5710: 5708: 5705: 5704: 5702: 5698: 5695: 5693: 5690: 5688: 5685: 5684: 5682: 5678: 5675: 5673: 5670: 5668: 5665: 5663: 5660: 5658: 5655: 5654: 5652: 5651: 5649: 5645: 5637: 5634: 5633: 5632: 5629: 5627: 5624: 5622: 5619: 5617: 5614: 5612: 5609: 5608: 5606: 5602: 5592: 5589: 5587: 5584: 5582: 5579: 5577: 5574: 5572: 5569: 5567: 5564: 5562: 5559: 5557: 5554: 5550: 5547: 5545: 5542: 5540: 5537: 5536: 5535: 5532: 5531: 5529: 5527: 5523: 5515: 5512: 5510: 5507: 5506: 5505: 5504: 5500: 5496: 5493: 5492: 5491: 5488: 5484: 5481: 5480: 5479: 5476: 5475: 5473: 5471: 5467: 5461: 5458: 5456: 5453: 5452: 5447: 5444: 5442: 5439: 5438: 5437: 5434: 5430: 5427: 5426: 5425: 5421: 5418: 5417: 5415: 5413: 5409: 5406: 5402: 5399: 5395: 5385: 5382: 5380: 5377: 5373: 5370: 5368: 5365: 5363: 5360: 5358: 5355: 5353: 5352:Louvel's sign 5350: 5348: 5347:Lisker's sign 5345: 5343: 5340: 5338: 5335: 5334: 5333: 5330: 5329: 5327: 5323: 5317: 5314: 5312: 5309: 5307: 5304: 5302: 5299: 5297: 5296:Thrombophilia 5294: 5293: 5291: 5289: 5285: 5279: 5276: 5272: 5269: 5268: 5267: 5264: 5260: 5257: 5255: 5252: 5250: 5247: 5246: 5245: 5242: 5238: 5235: 5233: 5230: 5228: 5225: 5223: 5220: 5218: 5215: 5213: 5210: 5209: 5208: 5205: 5204: 5202: 5198: 5195: 5191: 5185: 5182: 5180: 5177: 5175: 5172: 5171: 5168: 5164: 5160: 5157:Disorders of 5152: 5147: 5145: 5140: 5138: 5133: 5132: 5129: 5113: 5110: 5109: 5107: 5105: 5101: 5095: 5092: 5090: 5087: 5085: 5082: 5080: 5077: 5073: 5070: 5069: 5068: 5065: 5063: 5060: 5058: 5055: 5053: 5050: 5048: 5045: 5044: 5042: 5040: 5036: 5033: 5031: 5027: 5021: 5018: 5016: 5013: 5011: 5008: 5004: 5001: 4999: 4996: 4994: 4991: 4990: 4989: 4986: 4982: 4979: 4977: 4974: 4973: 4972: 4969: 4968: 4966: 4962: 4952: 4949: 4947: 4944: 4942: 4939: 4937: 4934: 4932: 4929: 4928: 4926: 4922: 4916: 4913: 4909: 4906: 4904: 4901: 4899: 4898:Caput medusae 4896: 4895: 4894: 4891: 4889: 4886: 4885: 4883: 4881: 4877: 4871: 4868: 4864: 4861: 4860: 4859: 4856: 4852: 4849: 4847: 4844: 4843: 4842: 4839: 4835: 4832: 4830: 4827: 4825: 4822: 4820: 4817: 4815: 4812: 4811: 4810: 4807: 4803: 4800: 4799: 4798: 4795: 4794: 4792: 4790: 4785: 4781: 4775: 4772: 4771: 4769: 4767: 4763: 4760: 4758: 4754: 4744: 4741: 4739: 4736: 4734: 4731: 4730: 4728: 4726: 4722: 4714: 4711: 4709: 4706: 4705: 4704: 4701: 4699: 4696: 4694: 4691: 4690: 4688: 4686: 4682: 4674: 4671: 4669: 4666: 4664: 4661: 4659: 4656: 4654: 4651: 4650: 4649: 4646: 4644: 4641: 4639: 4636: 4634: 4631: 4627: 4624: 4622: 4619: 4617: 4614: 4613: 4612: 4608: 4605: 4604: 4602: 4600: 4595: 4591: 4587: 4577: 4574: 4572: 4569: 4567: 4564: 4562: 4561:Degos disease 4559: 4557: 4554: 4553: 4551: 4547: 4541: 4538: 4536: 4533: 4532: 4530: 4528: 4524: 4516: 4513: 4511: 4508: 4506: 4503: 4501: 4498: 4496: 4493: 4491: 4488: 4487: 4486: 4483: 4481: 4478: 4477: 4472: 4469: 4467: 4464: 4462: 4459: 4457: 4454: 4452: 4449: 4448: 4447: 4444: 4443: 4441: 4439: 4435: 4432: 4430: 4426: 4420: 4417: 4413: 4410: 4409: 4408: 4405: 4404: 4402: 4400: 4396: 4393: 4391: 4386: 4382: 4378: 4373: 4366: 4361: 4359: 4354: 4352: 4347: 4346: 4343: 4330: 4326: 4325: 4321: 4319: 4315: 4311: 4307: 4303: 4302: 4298: 4294: 4292: 4288: 4284: 4283: 4279: 4275: 4274: 4271: 4266: 4262: 4256: 4252: 4249: 4246: 4241: 4237: 4236: 4226: 4220: 4216: 4211: 4207: 4201: 4197: 4192: 4188: 4182: 4178: 4173: 4169: 4163: 4159: 4154: 4150: 4144: 4140: 4135: 4134: 4121: 4117: 4112: 4107: 4103: 4099: 4095: 4091: 4087: 4083: 4079: 4072: 4064: 4060: 4056: 4052: 4048: 4044: 4040: 4036: 4032: 4028: 4021: 4014: 4012: 4003: 3999: 3995: 3991: 3987: 3983: 3979: 3975: 3971: 3967: 3960: 3952: 3948: 3944: 3940: 3936: 3932: 3928: 3924: 3920: 3914: 3906: 3902: 3898: 3894: 3890: 3886: 3882: 3878: 3874: 3870: 3863: 3861: 3845: 3841: 3835: 3827: 3823: 3819: 3815: 3810: 3805: 3801: 3797: 3793: 3789: 3785: 3777: 3769: 3765: 3761: 3757: 3752: 3747: 3743: 3739: 3735: 3731: 3727: 3719: 3711: 3707: 3702: 3697: 3693: 3689: 3682: 3675: 3667: 3663: 3659: 3655: 3651: 3647: 3642: 3637: 3634:(4): 278–88. 3633: 3629: 3622: 3614: 3610: 3606: 3602: 3598: 3594: 3590: 3586: 3579: 3577: 3569: 3568: 3563: 3558: 3550: 3546: 3541: 3536: 3532: 3528: 3524: 3517: 3515: 3507: 3506: 3501: 3496: 3488: 3484: 3480: 3476: 3472: 3468: 3463: 3458: 3454: 3450: 3446: 3439: 3431: 3427: 3422: 3417: 3413: 3409: 3404: 3399: 3395: 3391: 3387: 3380: 3372: 3368: 3364: 3360: 3355: 3350: 3346: 3342: 3338: 3331: 3323: 3319: 3315: 3311: 3306: 3301: 3297: 3293: 3289: 3282: 3274: 3270: 3266: 3262: 3258: 3254: 3250: 3246: 3238: 3230: 3226: 3221: 3216: 3211: 3206: 3202: 3198: 3194: 3187: 3179: 3175: 3171: 3167: 3163: 3159: 3155: 3151: 3147: 3143: 3136: 3128: 3122: 3118: 3111: 3109: 3107: 3099: 3095: 3092: 3087: 3085: 3083: 3081: 3079: 3070: 3066: 3061: 3056: 3052: 3048: 3044: 3037: 3029: 3025: 3020: 3015: 3010: 3005: 3001: 2997: 2993: 2986: 2978: 2974: 2970: 2966: 2962: 2958: 2954: 2950: 2946: 2942: 2934: 2926: 2922: 2917: 2912: 2908: 2904: 2900: 2896: 2892: 2888: 2884: 2877: 2869: 2865: 2861: 2857: 2853: 2849: 2845: 2841: 2837: 2833: 2825: 2817: 2811: 2806: 2798: 2794: 2790: 2786: 2782: 2778: 2774: 2770: 2763: 2747: 2746:"Pacing wire" 2741: 2733: 2727: 2722: 2720: 2718: 2716: 2707: 2701: 2696: 2694: 2692: 2690: 2688: 2686: 2684: 2682: 2680: 2678: 2676: 2674: 2672: 2670: 2668: 2666: 2664: 2662: 2660: 2658: 2656: 2654: 2652: 2650: 2641: 2635: 2630: 2628: 2619: 2613: 2608: 2606: 2604: 2602: 2600: 2598: 2596: 2594: 2592: 2583: 2577: 2572: 2570: 2568: 2566: 2564: 2562: 2560: 2558: 2556: 2554: 2545: 2541: 2536: 2531: 2527: 2523: 2519: 2515: 2511: 2507: 2503: 2496: 2494: 2492: 2490: 2481: 2475: 2470: 2462: 2456: 2451: 2449: 2440: 2434: 2429: 2427: 2425: 2423: 2421: 2419: 2417: 2415: 2413: 2411: 2409: 2407: 2405: 2403: 2401: 2399: 2397: 2395: 2393: 2384: 2380: 2375: 2370: 2366: 2362: 2358: 2351: 2340: 2336: 2332: 2328: 2324: 2320: 2313: 2305: 2301: 2297: 2293: 2289: 2285: 2281: 2277: 2273: 2269: 2262: 2260: 2252: 2248: 2244: 2241: 2236: 2225: 2219: 2203: 2199: 2193: 2185: 2181: 2176: 2171: 2167: 2163: 2159: 2152: 2137: 2133: 2127: 2119: 2113: 2105: 2101: 2096: 2091: 2087: 2083: 2079: 2075: 2071: 2064: 2056: 2052: 2048: 2044: 2040: 2036: 2032: 2027: 2022: 2018: 2014: 2010: 2003: 1988: 1984: 1978: 1970: 1966: 1962: 1958: 1955:(2): 89–127. 1954: 1950: 1943: 1935: 1931: 1926: 1921: 1917: 1913: 1909: 1905: 1902:(3): 77–104. 1901: 1897: 1893: 1886: 1878: 1872: 1868: 1861: 1853: 1849: 1845: 1841: 1837: 1833: 1826: 1822: 1812: 1809: 1807: 1804: 1802: 1799: 1797: 1794: 1793: 1787: 1785: 1775: 1773: 1766: 1756: 1754: 1750: 1740: 1732: 1730: 1720: 1718: 1714: 1710: 1701: 1699: 1695: 1690: 1685: 1681: 1677: 1672: 1671:Anticoagulant 1662: 1654: 1652: 1648: 1644: 1640: 1636: 1632: 1628: 1624: 1619: 1613: 1603: 1601: 1597: 1592: 1590: 1586: 1580: 1570: 1568: 1567:visual acuity 1564: 1560: 1556: 1551: 1547: 1543: 1537: 1535: 1531: 1530:smooth muscle 1527: 1523: 1519: 1518:wound healing 1515: 1511: 1507: 1503: 1502:wound healing 1497: 1495: 1491: 1477: 1475: 1471: 1467: 1463: 1459: 1455: 1451: 1447: 1443: 1442:venous stasis 1433: 1428: 1418: 1414: 1412: 1408: 1404: 1400: 1396: 1392: 1391:tissue factor 1388: 1378: 1376: 1372: 1368: 1367:thrombophilia 1362: 1361:Thrombophilia 1352: 1350: 1346: 1342: 1341:thrombophilia 1338: 1332: 1313: 1310: 1307: 1306: 1303: 1301: 1297: 1294: 1293: 1290: 1288: 1285: 1284: 1281: 1278: 1275: 1274: 1271: 1269: 1267: 1264: 1263: 1260: 1258: 1255: 1254: 1251: 1249: 1246: 1245: 1242: 1240: 1237: 1236: 1233: 1231: 1229: 1226: 1225: 1222: 1220: 1217: 1216: 1213: 1211: 1208: 1205: 1204: 1201: 1199: 1196: 1195: 1192: 1189: 1186: 1185: 1182: 1179: 1177: 1174: 1173: 1170: 1167: 1165: 1161: 1157: 1153: 1149: 1148: 1145: 1142: 1140: 1137: 1136: 1133: 1131: 1127: 1125: 1121: 1120: 1117: 1114: 1111: 1108: 1107: 1104: 1101: 1098: 1095: 1094: 1091: 1088: 1086: 1083: 1082: 1079: 1077: 1073: 1070: 1066: 1063: 1062: 1059: 1057: 1055: 1052: 1051: 1048: 1046: 1044: 1041: 1040: 1037: 1035: 1033: 1030: 1029: 1026: 1024: 1021: 1020: 1017: 1015: 1013: 1010: 1009: 1006: 1003: 1000: 999: 996: 994: 992: 989: 988: 985: 983: 981: 978: 975: 974: 971: 969: 967: 964: 963: 960: 958: 955: 954: 951: 949: 947: 944: 943: 940: 938: 935: 934: 931: 929: 926: 922: 921: 918: 916: 913: 912: 909: 906: 904: 901: 900: 897: 894: 892: 888: 887: 884: 882: 880: 877: 876: 873: 871: 868: 867: 864: 862: 860: 857: 856: 853: 851: 848: 847: 844: 841: 839: 836: 835: 832: 830: 828: 825: 824: 821: 819: 817: 814: 813: 810: 808: 805: 804: 801: 798: 796: 793: 792: 789: 786: 783: 782: 779: 776: 773: 772: 769: 767: 765:Heart failure 764: 763: 760: 758: 755: 754: 751: 748: 745: 744: 741: 739: 737: 734: 733: 730: 728: 725: 724: 720: 717: 714: 713: 707: 701: 697: 694: 691:vessel wall { 690: 687: 684: 683: 682: 680: 675: 673: 669: 665: 655: 653: 649: 640: 638: 631:Limb ischemia 628: 626: 622: 618: 612: 602: 600: 596: 592: 587: 582: 580: 576: 572: 563: 558: 548: 546: 541: 537: 533: 529: 519: 517: 513: 509: 508:double vision 505: 504:Streptococcal 501: 500:Staphyloccoal 497: 493: 489: 485: 481: 477: 472: 462: 460: 456: 452: 448: 439: 437: 433: 429: 425: 421: 417: 411: 401: 399: 395: 389: 379: 377: 373: 369: 365: 361: 357: 353: 347: 337: 335: 331: 327: 323: 319: 315: 311: 306: 296: 294: 290: 289:axillary vein 286: 282: 277: 267: 265: 257: 254: 251: 250: 249: 246: 244: 240: 236: 230: 219: 209: 201: 199: 195: 191: 187: 183: 179: 175: 171: 167: 163: 159: 154: 152: 147: 143: 139: 135: 131: 127: 123: 119: 115: 111: 107: 104: 103:Ancient Greek 100: 91: 89: 85: 82: 78: 74: 71: 69: 65: 61: 57: 53: 48: 43: 35: 30: 19: 5737:Hemarthrosis 5501: 5489: 5477: 5367:Pratt's sign 5305: 5287: 5179:coagulopathy 5039:Hypertension 5009: 4951:Venous ulcer 4857: 4840: 4808: 4796: 4766:Inflammation 4647: 4606: 4495:Hyperplastic 4456:Fatty streak 4399:Inflammation 4322: 4295: 4276: 4214: 4195: 4176: 4157: 4138: 4131:Bibliography 4085: 4081: 4071: 4030: 4026: 3969: 3965: 3959: 3926: 3922: 3913: 3872: 3868: 3847:. Retrieved 3843: 3834: 3794:(1): 11–20. 3791: 3787: 3776: 3751:11343/285435 3733: 3729: 3718: 3691: 3687: 3674: 3631: 3627: 3621: 3613:the original 3592: 3588: 3565: 3557: 3533:(3): 398–9. 3530: 3526: 3503: 3495: 3452: 3448: 3438: 3393: 3389: 3379: 3344: 3340: 3330: 3295: 3291: 3281: 3248: 3244: 3237: 3200: 3196: 3186: 3145: 3141: 3135: 3116: 3050: 3046: 3036: 2999: 2995: 2985: 2944: 2940: 2933: 2890: 2886: 2876: 2835: 2831: 2824: 2805: 2772: 2768: 2762: 2752:December 18, 2750:. Retrieved 2740: 2509: 2505: 2469: 2364: 2360: 2350: 2322: 2318: 2312: 2271: 2267: 2250: 2235: 2218: 2206:. Retrieved 2202:the original 2192: 2165: 2161: 2151: 2139:. Retrieved 2135: 2126: 2112:cite journal 2077: 2073: 2063: 2055:the original 2016: 2012: 2002: 1990:. Retrieved 1986: 1977: 1952: 1948: 1942: 1899: 1895: 1885: 1866: 1860: 1835: 1831: 1825: 1781: 1768: 1746: 1738: 1726: 1709:Thrombolysis 1707: 1704:Thrombolysis 1674: 1660: 1626: 1615: 1593: 1582: 1573:Embolization 1538: 1534:vasa vasorum 1498: 1490:Fibrinolysis 1488: 1474:ThroLy score 1462:malignancies 1439: 1415: 1403:downregulate 1384: 1366: 1364: 1339:which lists 1334: 1325:Pathogenesis 1054:Polycythemia 946:Pacing wires 816:Dysrhythmias 784:Plaster cast 705: 676: 672:inflammation 661: 646: 634: 614: 583: 581:(a bleed). 573:, thrombus, 568: 535: 525: 474: 447:Jugular vein 445: 413: 391: 364:pancreatitis 356:hypertension 349: 314:hepatic vein 308: 279: 261: 247: 243:femoral vein 232: 207: 155: 124:through the 118:blood vessel 110:(thrĂłmbōsis) 109: 106: 98: 97: 29: 5490:aggregation 5372:Rose's sign 5342:Homans sign 5174:Coagulation 5104:Hypotension 4648:head / neck 4500:Cholesterol 4390:capillaries 3809:2066/153000 2947:: 352–358. 2208:December 8, 1616:The use of 1130:blood clots 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Index

Thrombotic
Thrombosis (journal)

Cyanosis
Specialty
Vascular surgery
internal medicine
pulmonology
Symptoms
Ancient Greek
blood clot
blood vessel
blood
circulatory system
vein
artery
platelets
fibrin
blood clot
embolus
veins
venous thrombosis
arteries
arterial thrombosis
deep vein thrombosis
ischemia
necrosis
embolus
embolism
thromboembolism

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