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Vascular dementia

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1713: 72: 44: 340: 233:. These changes typically occur over a period of 5–10 years. Signs are typically the same as in other dementias, but mainly include cognitive decline and memory impairment of sufficient severity as to interfere with activities of daily living, sometimes with presence of focal neurological signs, and evidence of features consistent with cerebrovascular disease on brain imaging (CT or MRI). 690:
identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all-cause dementia was 1.69; for incident stroke, the pooled risk ratio was 2.18. Study characteristics did not modify
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of the illness is 1.5% in Western countries and approximately 2.2% in Japan. It accounts for 50% of all dementias in Japan, 20% to 40% in Europe and 15% in Latin America. 25% of people with stroke develop new-onset dementia within one year of their stroke. One study found that in the United States,
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Many studies have been conducted to determine average survival of people with dementia. The studies were frequently small and limited, which caused contradictory results in the connection of mortality to the type of dementia and the person's gender. One 2015 study found that the one-year mortality
169:. Restricted blood flow due to strokes reduces oxygen and glucose delivery to the brain, causing cell injury and neurological deficits in the affected region. Subtypes of vascular dementia include subcortical vascular dementia, multi-infarct dementia, stroke-related dementia, and mixed dementia. 588:
are irreversible, but the person with vascular dementia can demonstrate periods of stability or even mild improvement. Since stroke is an essential part of vascular dementia, the goal is to prevent new strokes. This is attempted through reduction of stroke risk factors, such as
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was three to four times higher in people after their first referral to a day clinic for dementia, when compared to the general population. If the person was hospitalized for dementia, the mortality was even higher than in people hospitalized for
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these associations, with the exception of sex, which explained 50.2% of between-study heterogeneity for prevalent stroke. These results confirm that stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.
656:. Vascular dementia was found to have either comparable or worse survival rates when compared to Alzheimer's disease; another 2014 study found that the prognosis for people with vascular dementia was worse for male and older people. 326:
Rare genetic disorders that cause vascular lesions in the brain have other presentation patterns. As a rule, they tend to occur earlier in life and have a more aggressive course. In addition, infectious disorders, such as
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criteria, Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN) criteria, the Alzheimer's Disease Diagnostic and Treatment Center criteria, and the Hachinski Ischemic Score (after
180:. Dementia may occur when neurodegenerative and cerebrovascular pathologies are mixed, as in susceptible elderly people (75 years and older). Cognitive decline can be traced back to occurrence of successive strokes. 371:
are the cause of dementia. A history of stroke increases the risk of developing dementia by around 70%, and recent stroke increases the risk by around 120%. Brain vascular lesions can also be the result of diffuse
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is substantially affected, with noticeable atrophy (tissue loss), in addition to calcification of the arteries. Microinfarcts may also be present in the gray matter (cerebral cortex), sometimes in large numbers.
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in the brain. Multi-infarct dementia results from a series of small strokes affecting several brain regions. Stroke-related dementia involving successive small strokes causes a more gradual decline in
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Gross examination of the brain may reveal noticeable lesions and damage to blood vessels. Accumulation of various substances such as lipid deposits and clotted blood appear on microscopic views. The
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Villarejo A, Benito-LeĂłn J, Trincado R, Posada IJ, Puertas-MartĂ­n V, Boix R, et al. (2011). "Dementia-associated mortality at thirteen years in the NEDICES Cohort Study".
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In a person already having dementia, SPECT appears to be superior in differentiating multi-infarct dementia from Alzheimer's disease, compared to the usual mental testing and
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the prevalence of vascular dementia in all people over the age of 71 is 2.43%, and another found that the prevalence of the dementias doubles with every 5.1 years of age.
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The recommended investigations for cognitive impairment include: blood tests (for anemia, vitamin deficiency, thyrotoxicosis, infection, among others), chest xray,
3158: 2357: 456: 448: 1630:"Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association" 303:, the frontal lobes are often affected. Consequently, people with vascular dementia tend to perform worse than their Alzheimer's disease counterparts in 435:
plaques in the walls of the cerebral arteries, leading to breakdown and rupture of the vessels. Since amyloid plaques are a characteristic feature of
1763:"Mortality risk after dementia diagnosis by dementia type and underlying factors: a cohort of 15,209 patients based on the Swedish Dementia Registry" 3354: 471:, and neuroimaging, preferably a scan with a functional or metabolic sensitivity beyond a simple CT or MRI. When available as a diagnostic tool, 3349: 4220: 541:
Differentiating dementia syndromes can be challenging, due to the frequently overlapping clinical features and related underlying pathology.
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Vascular dementia may be a direct cause of death due to the possibility of a fatal interruption in the brain's blood supply.
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drugs was ineffective in treating or preventing stroke or dementia in people without a history of cerebrovascular disease.
479:(PET) neuroimaging may be used to confirm a diagnosis of multi-infarct dementia in conjunction with evaluations involving 2841: 1989: 315:(lack of will or initiative), problems with attention, orientation, and urinary incontinence. They tend to exhibit more 4029: 3962: 3517: 2091: 2066: 1901: 621: 1672:"Prognosis of patients with dementia: results from a prospective nationwide registry linkage study in the Netherlands" 3732: 3535: 2877: 2697: 2595: 576:
of the major cerebral arteries is typical in vascular dementia, smaller vessels and arterioles are mainly affected.
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behavior. People with vascular dementia may also present with general slowing of processing ability, difficulty
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Early detection and accurate diagnosis are important, as vascular dementia is at least partially preventable.
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The incidence peaks between the fourth and the seventh decades of life and 80% of people have a history of
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Conditions that impair blood vessels in the brain and therefore interfere with oxygen delivery to the brain
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Goldstein LB, Toth PP, Dearborn-Tomazos JL, Giugliano RP, Hirsh BJ, Peña JM, et al. (October 2023).
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As of 2024, there are no medications used specifically for prevention or treatment of vascular dementia.
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Medications for high blood pressure are used to prevent pre-stroke dementia. These medications include
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and cerebrovascular disease, either clinically or based on neuro-imaging evidence of ischemic lesions.
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Engelhardt E, Tocquer C, AndrĂ© C, Moreira DM, Okamoto IH, Cavalcanti J, et al. (October 2011).
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Iadecola C, Duering M, Hachinski V, Joutel A, Pendlebury ST, Schneider JA, et al. (July 2019).
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Several specific diagnostic criteria can be used to diagnose vascular dementia, including the
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Custodio N, Montesinos R, Lira D, Herrera-PĂ©rez E, Bardales Y, Valeriano-Lorenzo L (2017).
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Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF (2019-06-11).
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The neurological signs localizing to certain areas of the brain that can be observed are
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Garcia-Ptacek S, Farahmand B, KĂĄreholt I, Religa D, Cuadrado ML, Eriksdotter M (2014).
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Heart disease, loss of ability to care for self,loss of ability to interact, pneumonia
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Erkinjuntti T (February 2012). Gelder M, Andreasen N, Lopez-Ibor J, Geddes J (eds.).
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KuĹşma E, Lourida I, Moore SF, Levine DA, Ukoumunne OC, Llewellyn DJ (November 2018).
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van de Vorst IE, Vaartjes I, Geerlings MI, Bots ML, Koek HL (October 2015).
3327: 3197: 3180: 2819: 2600: 2152: 1856: 1788: 1747: 1705: 1653: 1614: 1516: 1465: 1408: 1360: 1303: 1245: 1198: 1147: 1030:(5th ed.). Washington, DC: American Psychiatric Association. pp.  1010: 937: 817: 680: 590: 565: 526: 522: 432: 398: 307:
tasks, such as verbal fluency, and may present with frontal lobe problems:
304: 261: 241: 1481:"White matter degeneration in vascular and other ageing-related dementias" 4164: 3286: 3247: 3189: 2804: 2535: 2266: 2016: 364: 280:. In the more severely affected people, or those affected by infarcts in 269: 237: 111: 43: 3397: 3267: 3121: 2814: 2719: 2420: 2145: 2140: 1936: 1779: 1762: 672: 339: 289: 61: 4076: 1627: 1497: 1480: 1334: 4175: 3507: 3458: 3446: 3429: 3361: 3074: 3006: 2824: 2283: 2021: 1946: 1214:"Molecular mechanisms of cognitive impairment associated with stroke" 177: 65: 1760: 1081:"Vascular Dementia Clinical Presentation: History, Physical, Causes" 116:
High blood pressure, high cholesterol, atrial fibrillation, diabetes
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Spinal muscular atrophy with lower extremity predominance (SMALED)
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Vascular dementia is the second-most-common form of dementia after
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Diagnostic and statistical manual of mental disorders : DSM-5
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Brain health and pollution § Cognitive decline and dementia
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Risk factors and clinical characteristics for vascular dementia
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15-30% of dementia cases in the United States, Europe, and Asia
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Vascular dementia can be caused by ischemic or hemorrhagic
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Mixed dementia is diagnosed when people have evidence of
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Santisteban MM, Iadecola C, Carnevale D (January 2023).
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National Institute of Neurological Disorders and Stroke
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People with vascular dementia present with progressive
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Lab test, neuroimaging test, neuropsychological testing
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Diagnostic and Statistical Manual of Mental Disorders
4066: 1319:"Dementia: timely diagnosis and early intervention" 1914: 1835:Arteriosclerosis, Thrombosis, and Vascular Biology 1634:Arteriosclerosis, Thrombosis, and Vascular Biology 1316: 928:Sanders AE, Schoo C, Kalish VB (22 October 2023). 927: 1508:20.500.11820/780992bd-e933-4715-8099-c4d463070a58 1479:Hase Y, Horsburgh K, Ihara M, Kalaria RN (2018). 724:"ICD-11: Dementia due to cerebrovascular disease" 214:, frequently step-wise, after multiple strokes. 4197: 2323: 517:serology, calcium serum level, fasting glucose, 439:, vascular dementia may occur as a consequence. 427:Vascular dementia can sometimes be triggered by 144:There is no cure (however, symptoms are managed) 1841:(8). Arterioscler Thromb Vasc Biol: 1542–1549. 1544:(2 ed.). Oxford: Oxford University Press. 1056:"ICD-11 for Mortality and Morbidity Statistics" 932:. StatPearls, US National Library of Medicine. 886:. MedlinePlus, US National Library of Medicine. 3096: 1804:"Good Practice Series No 11- MEs and Dementia" 1317:Robinson L, Tang E, Taylor JP (16 June 2015). 397:for vascular dementia include increasing age, 351:affecting multiple brain areas, including the 288:areas, specific problems with speaking called 196:major or mild vascular neurocognitive disorder 3152: 1882: 1263: 1261: 1259: 1257: 1255: 1106:"CNS small vessel disease: A clinical review" 788:Journal of the American College of Cardiology 1828: 1531: 1161:Mossanen Parsi M, Duval C, AriĂ«ns R (2021). 977:"Vascular cognitive impairment and dementia" 784:"Vascular Cognitive Impairment and Dementia" 493:The screening blood tests typically include 3871: 1537: 777: 775: 773: 771: 769: 767: 765: 763: 761: 3159: 3145: 2786:Other specified feeding or eating disorder 2053: 1889: 1875: 1424:"Mixed dementia: A review of the evidence" 1252: 1211: 1078: 923: 921: 919: 917: 915: 913: 759: 757: 755: 753: 751: 749: 747: 745: 743: 741: 473:single photon emission computed tomography 172:Subcortical vascular dementia occurs from 70: 1846: 1801: 1778: 1695: 1621: 1604: 1506: 1496: 1455: 1398: 1350: 1293: 1188: 1178: 1137: 1024:American Psychiatric Association (2013). 1000: 911: 909: 907: 905: 903: 901: 899: 897: 895: 893: 807: 536: 3049:Disorganized (hebephrenic) schizophrenia 2645:Depersonalization-derealization disorder 974: 610:angiotensin converting enzyme inhibitors 549:often co-occurs with vascular dementia. 453:International Classification of Diseases 451:, Fourth Edition (DSM-IV) criteria, the 338: 35:Dementia due to cerebrovascular disease; 738: 718: 716: 455:, Tenth Edition (ICD-10) criteria, the 188:dementia due to cerebrovascular disease 4198: 3948:Distal hereditary motor neuronopathies 3621:Template:Demyelinating diseases of CNS 970: 968: 966: 964: 962: 960: 958: 956: 954: 890: 878: 835: 833: 831: 829: 827: 631:A 2023 review found that therapy with 3140: 3095: 2963: 2898: 2750: 2477: 2322: 2232: 2052: 1913: 1870: 1048: 876: 874: 872: 870: 868: 866: 864: 862: 860: 858: 201: 4221:Mental disorders due to brain damage 3799:Idiopathic intracranial hypertension 3188: 2233: 1572: 1212:Kaur M, Sharma S (1 February 2022). 1167:Frontiers in Cardiovascular Medicine 713: 363:. On rare occasion, infarcts in the 51:Brain atrophy from vascular dementia 2752:Physiological and physical behavior 1831:"Epidemiology of Vascular Dementia" 1795: 1017: 951: 824: 622:angiotensin II receptor antagonists 217:The disease is described as both a 13: 4030:Infantile progressive bulbar palsy 2698:Psychogenic non-epileptic seizures 2092:Emotional and behavioral disorders 1550:10.1093/med/9780199696758.001.0001 855: 194:lists vascular dementia as either 14: 4232: 3733:Template:Cerebrovascular diseases 3536:Frontotemporal lobar degeneration 2878:Hypoactive sexual desire disorder 1808:The Royal College of Pathologists 1597:10.1161/HYPERTENSIONAHA.122.18085 1541:New Oxford Textbook of Psychiatry 726:. World Health Organization. 2024 431:, which involves accumulation of 276:when compared with people having 3753:For more detailed coverage, see 3731:For more detailed coverage, see 3702:For more detailed coverage, see 3668:For more detailed coverage, see 3619:For more detailed coverage, see 2178:X-linked intellectual disability 1711: 1440:10.1590/1980-57642016dn11-040005 1391:10.1590/S1980-57642011DN05040003 620:, sympathetic nerve inhibitors, 42: 2007:Intermittent explosive disorder 1932:Ego-dystonic sexual orientation 1822: 1754: 1719: 1472: 1428:Dementia & Neuropsychologia 1415: 1379:Dementia & Neuropsychologia 1367: 1310: 1205: 1154: 1097: 662: 383: 210:, acutely or sub-acutely as in 2650:Dissociative identity disorder 1915:Adult personality and behavior 1767:Journal of Alzheimer's Disease 1728:Journal of Alzheimer's Disease 1072: 975:Wong CE, Chui CH (June 2022). 507:erythrocyte sedimentation rate 16:Dementia resulting from stroke 1: 4046:Amyotrophic lateral sclerosis 3931:Hereditary spastic paraplegia 3789:Normal pressure hydrocephalus 1829:Wolters FJ, Ikram MA (2019). 706: 586:Ischemic changes in the brain 579: 174:damage to small blood vessels 37:Vascular cognitive impairment 4015:Progressive muscular atrophy 3054:Pseudoneurotic schizophrenia 2591:Generalized anxiety disorder 2324:Neurological and symptomatic 1969:Sexual relationship disorder 1646:10.1161/ATV.0000000000000164 1122:10.1212/WNL.0000000000007654 993:10.1212/CON.0000000000001124 646: 638: 559: 477:positron emission tomography 442: 7: 3525:Primary progressive aphasia 2830:REM sleep behavior disorder 2299:Seasonal affective disorder 2097:Separation anxiety disorder 1688:10.1136/bmjopen-2015-008897 1286:10.1016/j.jalz.2018.06.3061 694: 429:cerebral amyloid angiopathy 186:lists vascular dementia as 10: 4237: 3847:Hashimoto's encephalopathy 3553:Posterior cortical atrophy 3374:Striatonigral degeneration 3225:Cavernous sinus thrombosis 3097:Symptoms and uncategorized 2198:developmental disabilities 1964:Sexual maturation disorder 1848:10.1161/ATVBAHA.119.311908 1274:Alzheimer's & Dementia 1230:10.1007/s11011-022-00901-0 800:10.1016/j.jacc.2019.04.034 387: 4155: 4070: 3953:Spinal muscular atrophies 3921:Primary lateral sclerosis 3903: 3880: 3864: 3819: 3779:Intracranial hypertension 3769: 3741: 3712: 3678: 3640: 3629: 3595: 3573: 3559:Creutzfeldt–Jakob disease 3498: 3308: 3299: 3285: 3245: 3179: 3102: 3091: 3067: 3059:Simple-type schizophrenia 3036: 3028:Schizophreniform disorder 3005: 2984: 2980: 2959: 2912: 2894: 2863: 2840: 2794: 2761: 2757: 2746: 2668: 2635: 2583: 2526: 2517: 2498: 2494: 2473: 2439: 2406:Mild cognitive impairment 2391:Creutzfeldt–Jakob disease 2371: 2333: 2329: 2318: 2289:Major depressive disorder 2242: 2228: 2194:Psychological development 2193: 2168: 2065: 2061: 2048: 1977: 1924: 1920: 1909: 1802:Fletcher, A (June 2023). 1485:Journal of Neurochemistry 481:mental status examination 334: 212:mild cognitive impairment 148: 140: 130: 120: 110: 102: 92: 79: 55: 50: 41: 31: 26: 4020:Progressive bulbar palsy 3811:Intracranial hypotension 3794:Choroid plexus papilloma 3208:Herpesviral encephalitis 3107:Impulse-control disorder 3023:Schizoaffective disorder 3018:Brief reactive psychosis 2715:Mass psychogenic illness 2678:Body dysmorphic disorder 2457:Post-concussion syndrome 2067:Emotional and behavioral 1180:10.3389/fcvm.2021.803169 618:calcium channel blockers 353:anterior cerebral artery 88:, short term memory loss 3532:Frontotemporal dementia 3218:Encephalitis lethargica 3044:Childhood schizophrenia 2396:Frontotemporal dementia 2353:High-functioning autism 2170:Intellectual disability 1740:10.3233/JAD-2011-110443 1218:Metabolic Brain Disease 595:high blood lipid levels 415:cerebrovascular disease 374:cerebrovascular disease 266:swallowing difficulties 3837:Hepatic encephalopathy 2561:Specific social phobia 2452:Organic brain syndrome 2294:Melancholic depression 2055:Childhood and learning 1085:emedicine.medscape.com 654:cardiovascular disease 626:adrenergic antagonists 537:Differential diagnosis 503:thyroid function tests 411:cardiovascular disease 344: 165:caused by a series of 132:Differential diagnosis 4216:Learning disabilities 3895:Ataxia–telangiectasia 3852:Static encephalopathy 3575:Mitochondrial disease 3413:Spasmodic torticollis 3323:Basal ganglia disease 3117:Psychomotor agitation 2907:and substance-related 2850:Postpartum depression 2730:Somatization disorder 2616:Acute stress reaction 2381:AIDS dementia complex 671:in older adults. The 342: 3842:Toxic encephalopathy 3548:Lewy bodies dementia 3112:KlĂĽver–Bucy syndrome 2942:Substance dependence 2855:Postpartum psychosis 2401:Huntington's disease 2183:Lujan–Fryns syndrome 2032:Personality disorder 701:Binswanger's disease 499:liver function tests 403:hypercholesterolemia 378:small vessel disease 301:small vessel disease 208:cognitive impairment 86:Cognitive impairment 4206:Cognitive disorders 3890:Friedreich's ataxia 3273:Meningoencephalitis 3213:Limbic encephalitis 2992:Delusional disorder 2937:Stimulant psychosis 2927:Physical dependence 2781:Rumination syndrome 2683:Conversion disorder 2660:Psychogenic amnesia 2510:with depressed mood 2508:Adjustment disorder 2411:Parkinson's disease 2386:Alzheimer's disease 2279:Atypical depression 2115:Social functioning 1990:Munchausen syndrome 1985:Factitious disorder 930:"Vascular dementia" 884:"Vascular dementia" 841:"Vascular dementia" 669:Alzheimer's disease 599:atrial fibrillation 591:high blood pressure 554:Alzheimer's disease 547:Alzheimer's disease 437:Alzheimer's disease 278:Alzheimer's disease 223:behavioral disorder 4156:External resources 3926:Pseudobulbar palsy 3664:Status epilepticus 3615:Multiple sclerosis 3452:Myoclonic epilepsy 3315:movement disorders 3261:Acute disseminated 3203:Viral encephalitis 3011:schizophrenia-like 2655:Dissociative fugue 2104:Movement disorders 1780:10.3233/JAD-131856 1079:Alagiakrishnan K. 511:C reactive protein 462:Vladimir Hachinski 345: 258:pseudobulbar palsy 202:Signs and symptoms 4193: 4192: 4064: 4063: 4060: 4059: 4056: 4055: 3860: 3859: 3765: 3764: 3704:Template:Headache 3670:Template:Epilepsy 3591: 3590: 3565:Vascular dementia 3408:Status dystonicus 3281: 3280: 3256:Encephalomyelitis 3134: 3133: 3130: 3129: 3087: 3086: 3083: 3082: 2955: 2954: 2890: 2889: 2886: 2885: 2742: 2741: 2738: 2737: 2631: 2630: 2469: 2468: 2465: 2464: 2426:Vascular dementia 2348:Asperger syndrome 2314: 2313: 2224: 2223: 2220: 2219: 2158:Tourette syndrome 2044: 2043: 2040: 2039: 1640:(10): e404–e442. 1559:978-0-19-969675-8 1498:10.1111/jnc.14271 1335:10.1136/bmj.h3029 1280:(11): 1416–1426. 1116:(24): 1146–1156. 1041:978-0-89042-554-1 794:(25): 3326–3344. 603:diabetes mellitus 505:, lipid profile, 407:diabetes mellitus 274:recall intrusions 159:Vascular dementia 156: 155: 136:Alzheimer disease 122:Diagnostic method 27:Vascular dementia 21:Medical condition 4228: 4068: 4067: 3878: 3877: 3869: 3868: 3827:Brain herniation 3638: 3637: 3478:Intention tremor 3473:Essential tremor 3338:Postencephalitic 3306: 3305: 3297: 3296: 3186: 3185: 3167:Diseases of the 3161: 3154: 3147: 3138: 3137: 3093: 3092: 2982: 2981: 2961: 2960: 2896: 2895: 2771:Anorexia nervosa 2759: 2758: 2748: 2747: 2725:Psychogenic pain 2693:Globus pharyngis 2541:Childhood phobia 2524: 2523: 2496: 2495: 2475: 2474: 2331: 2330: 2320: 2319: 2230: 2229: 2129:Selective mutism 2080:Conduct disorder 2063: 2062: 2050: 2049: 2027:Trichotillomania 2002:Gender dysphoria 1997:Fear of intimacy 1954:Sexual anhedonia 1922: 1921: 1911: 1910: 1898:Mental disorders 1891: 1884: 1877: 1868: 1867: 1861: 1860: 1850: 1826: 1820: 1819: 1817: 1815: 1799: 1793: 1792: 1782: 1758: 1752: 1751: 1723: 1717: 1716: 1715: 1709: 1699: 1667: 1658: 1657: 1625: 1619: 1618: 1608: 1576: 1570: 1569: 1567: 1566: 1535: 1529: 1528: 1510: 1500: 1476: 1470: 1469: 1459: 1419: 1413: 1412: 1402: 1371: 1365: 1364: 1354: 1314: 1308: 1307: 1297: 1265: 1250: 1249: 1209: 1203: 1202: 1192: 1182: 1158: 1152: 1151: 1141: 1101: 1095: 1094: 1092: 1091: 1076: 1070: 1069: 1067: 1066: 1052: 1046: 1045: 1021: 1015: 1014: 1004: 972: 949: 948: 946: 944: 925: 888: 887: 880: 853: 852: 850: 848: 837: 822: 821: 811: 779: 736: 735: 733: 731: 720: 495:full blood count 296:may be present. 250:plantar reflexes 75: 74: 46: 24: 23: 4236: 4235: 4231: 4230: 4229: 4227: 4226: 4225: 4196: 4195: 4194: 4189: 4188: 4151: 4150: 4079: 4065: 4052: 3978:Congenital DSMA 3899: 3856: 3815: 3761: 3749:Sleep disorders 3737: 3714:Cerebrovascular 3708: 3674: 3631: 3625: 3587: 3569: 3494: 3440:Choreoathetosis 3313: 3290: 3277: 3241: 3175: 3165: 3135: 3126: 3098: 3079: 3063: 3032: 3010: 3001: 2976: 2951: 2908: 2905:substance abuse 2882: 2859: 2836: 2790: 2776:Bulimia nervosa 2753: 2734: 2710:Hypochondriasis 2705:False pregnancy 2688:Ganser syndrome 2670:Somatic symptom 2664: 2627: 2579: 2568:Specific phobia 2513: 2490: 2461: 2435: 2367: 2363:Savant syndrome 2335:Autism spectrum 2325: 2310: 2238: 2216: 2195: 2189: 2164: 2057: 2036: 2012:Dermatillomania 1973: 1959:Sexual anorexia 1916: 1905: 1895: 1865: 1864: 1827: 1823: 1813: 1811: 1800: 1796: 1759: 1755: 1724: 1720: 1710: 1682:(10): e008897. 1668: 1661: 1626: 1622: 1577: 1573: 1564: 1562: 1560: 1536: 1532: 1477: 1473: 1420: 1416: 1372: 1368: 1315: 1311: 1266: 1253: 1210: 1206: 1159: 1155: 1102: 1098: 1089: 1087: 1077: 1073: 1064: 1062: 1054: 1053: 1049: 1042: 1022: 1018: 973: 952: 942: 940: 926: 891: 882: 881: 856: 846: 844: 839: 838: 825: 780: 739: 729: 727: 722: 721: 714: 709: 697: 665: 649: 641: 582: 562: 539: 488:medical history 445: 392: 386: 361:cingulate gyrus 355:territory, the 337: 204: 69: 36: 22: 17: 12: 11: 5: 4234: 4224: 4223: 4218: 4213: 4208: 4191: 4190: 4187: 4186: 4172: 4160: 4159: 4157: 4153: 4152: 4149: 4148: 4137: 4126: 4111: 4096: 4080: 4075: 4074: 4072: 4071:Classification 4062: 4061: 4058: 4057: 4054: 4053: 4051: 4050: 4049: 4048: 4037: 4036: 4035: 4034: 4033: 4032: 4027: 4017: 4012: 4011: 4010: 4005: 4000: 3999: 3998: 3993: 3988: 3980: 3975: 3970: 3965: 3960: 3950: 3936: 3935: 3934: 3933: 3928: 3923: 3909: 3907: 3901: 3900: 3898: 3897: 3892: 3886: 3884: 3875: 3866: 3862: 3861: 3858: 3857: 3855: 3854: 3849: 3844: 3839: 3834: 3829: 3823: 3821: 3817: 3816: 3814: 3813: 3808: 3806:Cerebral edema 3803: 3802: 3801: 3796: 3791: 3786: 3775: 3773: 3767: 3766: 3763: 3762: 3760: 3759: 3758: 3757: 3755:Template:Sleep 3745: 3743: 3739: 3738: 3736: 3735: 3729: 3724: 3718: 3716: 3710: 3709: 3707: 3706: 3700: 3695: 3690: 3684: 3682: 3676: 3675: 3673: 3672: 3666: 3661: 3656: 3650: 3648: 3635: 3627: 3626: 3624: 3623: 3617: 3612: 3607: 3601: 3599: 3593: 3592: 3589: 3588: 3586: 3585: 3583:Leigh syndrome 3579: 3577: 3571: 3570: 3568: 3567: 3556: 3555: 3550: 3545: 3544: 3543: 3529: 3528: 3527: 3522: 3521: 3520: 3504: 3502: 3496: 3495: 3493: 3492: 3487: 3482: 3481: 3480: 3475: 3464: 3463: 3462: 3461: 3456: 3455: 3454: 3444: 3443: 3442: 3432: 3427: 3426: 3425: 3420: 3415: 3410: 3394: 3393: 3392: 3391: 3386: 3381: 3376: 3371: 3370: 3369: 3359: 3358: 3357: 3347: 3346: 3345: 3340: 3335: 3319: 3317: 3310:Extrapyramidal 3303: 3294: 3292:encephalopathy 3283: 3282: 3279: 3278: 3276: 3275: 3270: 3265: 3264: 3263: 3252: 3250: 3243: 3242: 3240: 3239: 3238: 3237: 3227: 3222: 3221: 3220: 3215: 3210: 3205: 3194: 3192: 3183: 3177: 3176: 3169:nervous system 3164: 3163: 3156: 3149: 3141: 3132: 3131: 3128: 3127: 3125: 3124: 3119: 3114: 3109: 3103: 3100: 3099: 3089: 3088: 3085: 3084: 3081: 3080: 3078: 3077: 3071: 3069: 3065: 3064: 3062: 3061: 3056: 3051: 3046: 3040: 3038: 3034: 3033: 3031: 3030: 3025: 3020: 3014: 3012: 3003: 3002: 3000: 2999: 2994: 2988: 2986: 2978: 2977: 2957: 2956: 2953: 2952: 2950: 2949: 2944: 2939: 2934: 2932:Rebound effect 2929: 2924: 2919: 2913: 2910: 2909: 2892: 2891: 2888: 2887: 2884: 2883: 2881: 2880: 2875: 2873:Hypersexuality 2869: 2867: 2861: 2860: 2858: 2857: 2852: 2846: 2844: 2838: 2837: 2835: 2834: 2833: 2832: 2827: 2822: 2812: 2807: 2801: 2799: 2792: 2791: 2789: 2788: 2783: 2778: 2773: 2767: 2765: 2755: 2754: 2744: 2743: 2740: 2739: 2736: 2735: 2733: 2732: 2727: 2722: 2717: 2712: 2707: 2702: 2701: 2700: 2695: 2690: 2680: 2674: 2672: 2666: 2665: 2663: 2662: 2657: 2652: 2647: 2641: 2639: 2633: 2632: 2629: 2628: 2626: 2625: 2624: 2623: 2618: 2608: 2606:Panic disorder 2603: 2598: 2593: 2587: 2585: 2581: 2580: 2578: 2577: 2576: 2575: 2573:Claustrophobia 2565: 2564: 2563: 2558: 2556:Anthropophobia 2548: 2546:Social anxiety 2543: 2538: 2532: 2530: 2521: 2515: 2514: 2512: 2511: 2504: 2502: 2492: 2491: 2471: 2470: 2467: 2466: 2463: 2462: 2460: 2459: 2454: 2449: 2443: 2441: 2437: 2436: 2434: 2433: 2428: 2423: 2418: 2416:Pick's disease 2413: 2408: 2403: 2398: 2393: 2388: 2383: 2377: 2375: 2369: 2368: 2366: 2365: 2360: 2355: 2350: 2345: 2339: 2337: 2327: 2326: 2316: 2315: 2312: 2311: 2309: 2308: 2303: 2302: 2301: 2296: 2291: 2286: 2281: 2271: 2270: 2269: 2264: 2259: 2254: 2243: 2240: 2239: 2226: 2225: 2222: 2221: 2218: 2217: 2215: 2214: 2209: 2203: 2201: 2191: 2190: 2188: 2187: 2186: 2185: 2174: 2172: 2166: 2165: 2163: 2162: 2161: 2160: 2150: 2149: 2148: 2143: 2133: 2132: 2131: 2126: 2121: 2113: 2112: 2111: 2101: 2100: 2099: 2089: 2088: 2087: 2077: 2071: 2069: 2059: 2058: 2046: 2045: 2042: 2041: 2038: 2037: 2035: 2034: 2029: 2024: 2019: 2014: 2009: 2004: 1999: 1994: 1993: 1992: 1981: 1979: 1975: 1974: 1972: 1971: 1966: 1961: 1956: 1951: 1950: 1949: 1944: 1934: 1928: 1926: 1918: 1917: 1907: 1906: 1902:Classification 1894: 1893: 1886: 1879: 1871: 1863: 1862: 1821: 1794: 1753: 1718: 1659: 1620: 1571: 1558: 1530: 1491:(5): 617–633. 1471: 1434:(4): 364–370. 1414: 1385:(4): 251–263. 1366: 1309: 1251: 1224:(2): 279–287. 1204: 1153: 1096: 1071: 1047: 1040: 1016: 987:(3): 750–780. 950: 889: 854: 823: 737: 711: 710: 708: 705: 704: 703: 696: 693: 664: 661: 648: 645: 640: 637: 581: 578: 561: 558: 543:Mixed dementia 538: 535: 444: 441: 385: 382: 357:parietal lobes 336: 333: 203: 200: 154: 153: 150: 146: 145: 142: 138: 137: 134: 128: 127: 124: 118: 117: 114: 108: 107: 104: 100: 99: 96: 90: 89: 83: 77: 76: 59: 53: 52: 48: 47: 39: 38: 33: 29: 28: 20: 15: 9: 6: 4: 3: 2: 4233: 4222: 4219: 4217: 4214: 4212: 4209: 4207: 4204: 4203: 4201: 4185: 4182: 4178: 4177: 4173: 4171: 4167: 4166: 4162: 4161: 4158: 4154: 4147: 4143: 4142: 4138: 4136: 4132: 4131: 4127: 4125: 4121: 4120: 4116: 4112: 4110: 4106: 4105: 4101: 4097: 4095: 4091: 4090: 4086: 4082: 4081: 4078: 4073: 4069: 4047: 4044: 4043: 4042: 4039: 4038: 4031: 4028: 4026: 4023: 4022: 4021: 4018: 4016: 4013: 4009: 4006: 4004: 4001: 3997: 3994: 3992: 3989: 3987: 3984: 3983: 3981: 3979: 3976: 3974: 3971: 3969: 3966: 3964: 3961: 3959: 3956: 3955: 3954: 3951: 3949: 3946: 3945: 3944: 3942: 3938: 3937: 3932: 3929: 3927: 3924: 3922: 3919: 3918: 3917: 3915: 3911: 3910: 3908: 3906: 3902: 3896: 3893: 3891: 3888: 3887: 3885: 3883: 3879: 3876: 3874: 3870: 3867: 3863: 3853: 3850: 3848: 3845: 3843: 3840: 3838: 3835: 3833: 3832:Reye syndrome 3830: 3828: 3825: 3824: 3822: 3818: 3812: 3809: 3807: 3804: 3800: 3797: 3795: 3792: 3790: 3787: 3785: 3784:Hydrocephalus 3782: 3781: 3780: 3777: 3776: 3774: 3772: 3768: 3756: 3752: 3751: 3750: 3747: 3746: 3744: 3740: 3734: 3730: 3728: 3725: 3723: 3720: 3719: 3717: 3715: 3711: 3705: 3701: 3699: 3696: 3694: 3691: 3689: 3686: 3685: 3683: 3681: 3677: 3671: 3667: 3665: 3662: 3660: 3657: 3655: 3652: 3651: 3649: 3647: 3643: 3639: 3636: 3634: 3628: 3622: 3618: 3616: 3613: 3611: 3608: 3606: 3603: 3602: 3600: 3598: 3597:Demyelinating 3594: 3584: 3581: 3580: 3578: 3576: 3572: 3566: 3563: 3562: 3561: 3560: 3554: 3551: 3549: 3546: 3542: 3539: 3538: 3537: 3533: 3530: 3526: 3523: 3519: 3516: 3515: 3514: 3511: 3510: 3509: 3506: 3505: 3503: 3501: 3497: 3491: 3488: 3486: 3485:Restless legs 3483: 3479: 3476: 3474: 3471: 3470: 3469: 3466: 3465: 3460: 3457: 3453: 3450: 3449: 3448: 3445: 3441: 3438: 3437: 3436: 3433: 3431: 3428: 3424: 3423:Blepharospasm 3421: 3419: 3416: 3414: 3411: 3409: 3406: 3405: 3404: 3401: 3400: 3399: 3396: 3395: 3390: 3387: 3385: 3382: 3380: 3379:Hemiballismus 3377: 3375: 3372: 3368: 3365: 3364: 3363: 3360: 3356: 3353: 3352: 3351: 3348: 3344: 3341: 3339: 3336: 3334: 3331: 3330: 3329: 3326: 3325: 3324: 3321: 3320: 3318: 3316: 3311: 3307: 3304: 3302: 3298: 3295: 3293: 3288: 3284: 3274: 3271: 3269: 3266: 3262: 3259: 3258: 3257: 3254: 3253: 3251: 3249: 3244: 3236: 3233: 3232: 3231: 3230:Brain abscess 3228: 3226: 3223: 3219: 3216: 3214: 3211: 3209: 3206: 3204: 3201: 3200: 3199: 3196: 3195: 3193: 3191: 3187: 3184: 3182: 3178: 3174: 3170: 3162: 3157: 3155: 3150: 3148: 3143: 3142: 3139: 3123: 3120: 3118: 3115: 3113: 3110: 3108: 3105: 3104: 3101: 3094: 3090: 3076: 3073: 3072: 3070: 3066: 3060: 3057: 3055: 3052: 3050: 3047: 3045: 3042: 3041: 3039: 3037:Schizophrenia 3035: 3029: 3026: 3024: 3021: 3019: 3016: 3015: 3013: 3008: 3004: 2998: 2995: 2993: 2990: 2989: 2987: 2983: 2979: 2975: 2971: 2967: 2966:Schizophrenia 2962: 2958: 2948: 2945: 2943: 2940: 2938: 2935: 2933: 2930: 2928: 2925: 2923: 2920: 2918: 2917:Drug overdose 2915: 2914: 2911: 2906: 2902: 2897: 2893: 2879: 2876: 2874: 2871: 2870: 2868: 2866: 2865:Sexual desire 2862: 2856: 2853: 2851: 2848: 2847: 2845: 2843: 2839: 2831: 2828: 2826: 2823: 2821: 2818: 2817: 2816: 2813: 2811: 2808: 2806: 2803: 2802: 2800: 2798: 2793: 2787: 2784: 2782: 2779: 2777: 2774: 2772: 2769: 2768: 2766: 2764: 2760: 2756: 2749: 2745: 2731: 2728: 2726: 2723: 2721: 2718: 2716: 2713: 2711: 2708: 2706: 2703: 2699: 2696: 2694: 2691: 2689: 2686: 2685: 2684: 2681: 2679: 2676: 2675: 2673: 2671: 2667: 2661: 2658: 2656: 2653: 2651: 2648: 2646: 2643: 2642: 2640: 2638: 2634: 2622: 2619: 2617: 2614: 2613: 2612: 2609: 2607: 2604: 2602: 2599: 2597: 2594: 2592: 2589: 2588: 2586: 2582: 2574: 2571: 2570: 2569: 2566: 2562: 2559: 2557: 2554: 2553: 2552: 2551:Social phobia 2549: 2547: 2544: 2542: 2539: 2537: 2534: 2533: 2531: 2529: 2525: 2522: 2520: 2516: 2509: 2506: 2505: 2503: 2501: 2497: 2493: 2489: 2486:-related and 2485: 2481: 2476: 2472: 2458: 2455: 2453: 2450: 2448: 2445: 2444: 2442: 2438: 2432: 2429: 2427: 2424: 2422: 2419: 2417: 2414: 2412: 2409: 2407: 2404: 2402: 2399: 2397: 2394: 2392: 2389: 2387: 2384: 2382: 2379: 2378: 2376: 2374: 2370: 2364: 2361: 2359: 2356: 2354: 2351: 2349: 2346: 2344: 2341: 2340: 2338: 2336: 2332: 2328: 2321: 2317: 2307: 2304: 2300: 2297: 2295: 2292: 2290: 2287: 2285: 2282: 2280: 2277: 2276: 2275: 2272: 2268: 2265: 2263: 2260: 2258: 2255: 2253: 2250: 2249: 2248: 2245: 2244: 2241: 2236: 2231: 2227: 2213: 2210: 2208: 2205: 2204: 2202: 2199: 2192: 2184: 2181: 2180: 2179: 2176: 2175: 2173: 2171: 2167: 2159: 2156: 2155: 2154: 2151: 2147: 2144: 2142: 2139: 2138: 2137: 2134: 2130: 2127: 2125: 2122: 2120: 2117: 2116: 2114: 2110: 2107: 2106: 2105: 2102: 2098: 2095: 2094: 2093: 2090: 2086: 2083: 2082: 2081: 2078: 2076: 2073: 2072: 2070: 2068: 2064: 2060: 2056: 2051: 2047: 2033: 2030: 2028: 2025: 2023: 2020: 2018: 2015: 2013: 2010: 2008: 2005: 2003: 2000: 1998: 1995: 1991: 1988: 1987: 1986: 1983: 1982: 1980: 1976: 1970: 1967: 1965: 1962: 1960: 1957: 1955: 1952: 1948: 1945: 1943: 1940: 1939: 1938: 1935: 1933: 1930: 1929: 1927: 1923: 1919: 1912: 1908: 1903: 1899: 1892: 1887: 1885: 1880: 1878: 1873: 1872: 1869: 1858: 1854: 1849: 1844: 1840: 1836: 1832: 1825: 1809: 1805: 1798: 1790: 1786: 1781: 1776: 1773:(2): 467–77. 1772: 1768: 1764: 1757: 1749: 1745: 1741: 1737: 1734:(3): 543–51. 1733: 1729: 1722: 1714: 1707: 1703: 1698: 1693: 1689: 1685: 1681: 1677: 1673: 1666: 1664: 1655: 1651: 1647: 1643: 1639: 1635: 1631: 1624: 1616: 1612: 1607: 1602: 1598: 1594: 1590: 1586: 1582: 1575: 1561: 1555: 1551: 1547: 1543: 1542: 1534: 1526: 1522: 1518: 1514: 1509: 1504: 1499: 1494: 1490: 1486: 1482: 1475: 1467: 1463: 1458: 1453: 1449: 1445: 1441: 1437: 1433: 1429: 1425: 1418: 1410: 1406: 1401: 1396: 1392: 1388: 1384: 1380: 1377: 1370: 1362: 1358: 1353: 1348: 1344: 1340: 1336: 1332: 1328: 1324: 1320: 1313: 1305: 1301: 1296: 1291: 1287: 1283: 1279: 1275: 1271: 1264: 1262: 1260: 1258: 1256: 1247: 1243: 1239: 1235: 1231: 1227: 1223: 1219: 1215: 1208: 1200: 1196: 1191: 1186: 1181: 1176: 1172: 1168: 1164: 1157: 1149: 1145: 1140: 1135: 1131: 1127: 1123: 1119: 1115: 1111: 1107: 1100: 1086: 1082: 1075: 1061: 1057: 1051: 1043: 1037: 1033: 1029: 1028: 1020: 1012: 1008: 1003: 998: 994: 990: 986: 982: 978: 971: 969: 967: 965: 963: 961: 959: 957: 955: 939: 935: 931: 924: 922: 920: 918: 916: 914: 912: 910: 908: 906: 904: 902: 900: 898: 896: 894: 885: 879: 877: 875: 873: 871: 869: 867: 865: 863: 861: 859: 842: 836: 834: 832: 830: 828: 819: 815: 810: 805: 801: 797: 793: 789: 785: 778: 776: 774: 772: 770: 768: 766: 764: 762: 760: 758: 756: 754: 752: 750: 748: 746: 744: 742: 725: 719: 717: 712: 702: 699: 698: 692: 689: 688:meta-analysis 684: 682: 677: 674: 670: 660: 657: 655: 644: 636: 634: 629: 627: 623: 619: 615: 611: 606: 604: 600: 596: 592: 587: 577: 575: 570: 567: 557: 555: 550: 548: 544: 534: 532: 528: 524: 520: 516: 512: 508: 504: 500: 496: 491: 489: 484: 482: 478: 474: 470: 465: 463: 458: 454: 450: 440: 438: 434: 430: 425: 423: 420: 416: 412: 408: 404: 400: 396: 391: 381: 379: 375: 370: 366: 362: 358: 354: 350: 341: 332: 330: 324: 322: 321:shifting sets 318: 317:perseverative 314: 310: 306: 302: 297: 295: 291: 287: 283: 279: 275: 271: 267: 264:problems and 263: 260:, as well as 259: 255: 251: 247: 246:hyperreflexia 243: 239: 234: 232: 228: 224: 220: 215: 213: 209: 199: 197: 193: 189: 185: 181: 179: 175: 170: 168: 164: 160: 151: 147: 143: 139: 135: 133: 129: 125: 123: 119: 115: 113: 109: 105: 101: 97: 95: 94:Complications 91: 87: 84: 82: 78: 73: 67: 63: 60: 58: 54: 49: 45: 40: 34: 30: 25: 19: 4174: 4163: 4139: 4128: 4113: 4098: 4083: 4040: 3939: 3912: 3873:Degenerative 3610:Inflammatory 3564: 3557: 3490:Stiff-person 3328:Parkinsonism 3301:Degenerative 3198:Encephalitis 3181:Inflammation 3171:, primarily 2997:Folie Ă  deux 2922:Intoxication 2903:substances, 2901:Psychoactive 2820:Night terror 2637:Dissociative 2601:Panic attack 2425: 2153:Tic disorder 1838: 1834: 1824: 1812:. Retrieved 1807: 1797: 1770: 1766: 1756: 1731: 1727: 1721: 1679: 1675: 1637: 1633: 1623: 1591:(1): 22–34. 1588: 1585:Hypertension 1584: 1574: 1563:. Retrieved 1540: 1533: 1488: 1484: 1474: 1431: 1427: 1417: 1382: 1378: 1369: 1326: 1322: 1312: 1277: 1273: 1221: 1217: 1207: 1170: 1166: 1156: 1113: 1109: 1099: 1088:. Retrieved 1084: 1074: 1063:. Retrieved 1059: 1050: 1026: 1019: 984: 980: 941:. Retrieved 845:. Retrieved 791: 787: 728:. Retrieved 685: 681:hypertension 678: 666: 663:Epidemiology 658: 650: 642: 630: 607: 583: 571: 566:white matter 563: 551: 540: 527:vitamin B-12 523:electrolytes 492: 485: 475:(SPECT) and 466: 446: 433:amyloid beta 426: 399:hypertension 395:Risk factors 393: 384:Risk factors 346: 325: 305:frontal lobe 298: 242:bradykinesia 235: 216: 205: 195: 187: 182: 171: 158: 157: 112:Risk factors 18: 4165:MedlinePlus 4025:Fazio–Londe 3865:Both/either 3659:Generalised 3518:Early-onset 3513:Alzheimer's 3248:spinal cord 2970:schizotypal 2805:Hypersomnia 2795:Nonorganic 2536:Agoraphobia 2267:Cyclothymia 2262:Bipolar NOS 2237:(affective) 2109:Stereotypic 2017:Kleptomania 1810:. p. 8 1060:icd.who.int 401:, smoking, 365:hippocampus 270:free recall 248:, extensor 238:hemiparesis 225:within the 32:Other names 4200:Categories 4141:DiseasesDB 3633:paroxysmal 3605:Autoimmune 3398:Dyskinesia 3268:Meningitis 3246:Brain and 3122:Stereotypy 2985:Delusional 2974:delusional 2947:Withdrawal 2815:Parasomnia 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Index


Specialty
Psychiatry
neurology
Edit this on Wikidata
Symptoms
Cognitive impairment
Complications
Risk factors
Diagnostic method
Differential diagnosis
dementia
strokes
damage to small blood vessels
cognition
ICD-11
DSM-5
cognitive impairment
mild cognitive impairment
mental
behavioral disorder
ICD-11
affective
hemiparesis
bradykinesia
hyperreflexia
plantar reflexes
ataxia
pseudobulbar palsy
gait

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