265:
24:
33:
400:
473:
and that already showed elevated urine mercury levels. The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.
477:
DMPS administered to a mercury poisoned animal model failed to remove the mercury from tissues and reduce the inorganic mercury burden in the brain, indicating it is not a useful intra-cellular chelation agent.
609:
Aposhian, H.V.; Aposhian, M.M. (1990). "Meso-2,3-dimercaptosuccinic acid: Chemical, pharmacological and toxicological properties of an orally effective metal chelating agent".
413:
408:
314:
806:
644:
D. Gonzalez-Ramirez; M. Zuniga-Charles; A. Narro-Juarez; Y. Molina-Recio; K. M. Hurlbut; R. C. Dart; H. V. Aposhian (1 October 1998).
678:
Rooney, James (2007). "The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury".
646:"DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride"
971:
571:
462:-210, were investigated in the following years. DMPS was found to have some protective effect, prolonging the survival time.
750:"Stevens–Johnson syndrome in a child with chronic mercury exposure and 2,3-dimercaptopropane-1-sulfonate (DMPS) therapy"
503:) in mouse models when given soon after exposure, suggesting its potential for repurposing as a prehospital treatment.
279:
112:
105:
988:
420:
891:
799:
482:
222:
243:
784:
555:
189:
590:
Petrunkin, V. E. (1956). "Synthesis and properties of dimercapto derivatives of alkylsulfonic acids".
1015:
792:
578:
The prefixes 'mercapto' (–SH), and 'hydroseleno' or selenyl (–SeH), etc. are no longer recommended.
552:
Nomenclature of
Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book)
260:
183:
643:
1020:
976:
947:
517:
455:
713:
Guzzi, GianPaolo; Caterina A.M. La Porta (2008). "Molecular mechanisms triggered by mercury".
645:
527:
454:
The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. The effects of DMPS on
231:
45:
152:
8:
492:
A 2020 study found DMPS to provide some benefits taken orally in mitigating effects from
71:
622:
264:
81:
23:
1030:
470:
465:
A study was undertaken of DMPS use by workers involved in the production of a calomel
132:
819:
771:
730:
695:
660:
626:
567:
532:
512:
486:
761:
722:
687:
618:
559:
342:
1025:
957:
823:
444:
211:
563:
982:
489:
with DMPS; the SJS resolved gradually after the chelation therapy was stopped.
466:
391:
766:
749:
726:
691:
1009:
952:
916:
840:
868:
775:
734:
699:
664:
630:
932:
896:
886:
863:
858:
448:
814:
747:
376:
143:
815:
493:
390:
Except where otherwise noted, data are given for materials in their
908:
459:
447:
that form complexes with various heavy metals. They are related to
172:
748:
Van der Linde AA, Pillen S, Gerrits GP, Bouwes
Bavinck JN (2008).
111:
104:
198:
32:
832:
937:
497:
123:
94:
608:
485:(SJS), a potentially serious disease, in a child undergoing
288:
InChI=1S/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6)
248:
878:
850:
712:
522:
298:
InChI=1/C3H8O3S3/c4-9(5,6)2-3(8)1-7/h3,7-8H,1-2H2,(H,4,5,6)
163:
653:
1007:
210:
80:
800:
611:Annual Review of Pharmacology and Toxicology
807:
793:
263:
151:
765:
589:
230:
544:
50:2,3-Bis(sulfanyl)propane-1-sulfonic acid
259:
188:
1008:
677:
17:2,3-Dimercapto-1-propanesulfonic acid
788:
433:2,3-Dimercapto-1-propanesulfonic acid
291:Key: JLVSRWOIZZXQAD-UHFFFAOYSA-N
131:
59:2,3-Dimercaptopropane-1-sulfonic acid
451:, which is another chelating agent.
623:10.1146/annurev.pa.30.040190.001431
301:Key: JLVSRWOIZZXQAD-UHFFFAOYAD
201:
171:
13:
469:lotion and in direct contact with
14:
1042:
481:A 2008 study reported a case of
439:) and its sodium salt (known as
398:
354:
31:
22:
394:(at 25 °C , 100 kPa).
741:
706:
671:
637:
602:
583:
556:The Royal Society of Chemistry
366:
360:
348:
1:
592:Ukrainsky Khemichisky Zhurnal
538:
496:snakebites (using venom from
7:
564:10.1039/9781849733069-FP001
506:
10:
1047:
458:poisoning, including with
966:
925:
907:
877:
849:
831:
767:10.1080/15563650701779687
727:10.1016/j.tox.2007.11.002
692:10.1016/j.tox.2007.02.016
388:
335:
310:
275:
64:
56:
44:
39:
30:
21:
483:Stevens–Johnson syndrome
518:Dimercaptosuccinic acid
558:. 2014. p. 697.
528:Heavy metal poisoning
46:Preferred IUPAC name
384: g·mol
18:
993:Never to phase III
471:mercurous chloride
421:Infobox references
16:
1003:
1002:
820:chelation therapy
573:978-0-85404-182-4
533:Mercury poisoning
513:Chelation therapy
498:saw-scaled vipers
487:chelation therapy
429:Chemical compound
427:
426:
327:O=S(=O)(O)CC(S)CS
322:OS(=O)(=O)CC(S)CS
244:CompTox Dashboard
113:Interactive image
106:Interactive image
1038:
1016:Chelating agents
816:Chelating agents
809:
802:
795:
786:
785:
780:
779:
769:
745:
739:
738:
710:
704:
703:
675:
669:
668:
650:
649:(free full text)
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635:
634:
606:
600:
599:
587:
581:
580:
548:
445:chelating agents
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405:
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356:
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343:Chemical formula
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135:
115:
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84:
35:
26:
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15:
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1035:
1006:
1005:
1004:
999:
998:
983:Clinical trials
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827:
813:
783:
746:
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648:
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638:
607:
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588:
584:
574:
550:
549:
545:
541:
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501:Viperidae Echis
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423:
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416: ?)
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87:
74:
60:
52:
51:
12:
11:
5:
1044:
1034:
1033:
1028:
1023:
1021:Sulfonic acids
1018:
1001:
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991:
980:
974:
968:
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843:
837:
835:
829:
828:
812:
811:
804:
797:
789:
782:
781:
740:
705:
686:(3): 145–156.
670:
636:
617:(1): 279–306.
601:
582:
572:
542:
540:
537:
536:
535:
530:
525:
520:
515:
508:
505:
467:skin bleaching
428:
425:
424:
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397:
396:
392:standard state
389:
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37:
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28:
27:
9:
6:
4:
3:
2:
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1032:
1029:
1027:
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1022:
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1011:
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987:
986:
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978:
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951:
949:
946:
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936:
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931:
930:
928:
924:
918:
917:Prussian blue
915:
914:
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910:
906:
898:
895:
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893:
890:
888:
885:
884:
882:
880:
876:
870:
867:
865:
862:
860:
857:
856:
854:
852:
848:
842:
841:Penicillamine
839:
838:
836:
834:
830:
825:
821:
817:
810:
805:
803:
798:
796:
791:
790:
787:
777:
773:
768:
763:
760:(5): 479–81.
759:
755:
751:
744:
736:
732:
728:
724:
720:
716:
709:
701:
697:
693:
689:
685:
681:
674:
666:
662:
658:
654:
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632:
628:
624:
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616:
612:
605:
597:
593:
586:
579:
575:
569:
565:
561:
557:
554:. Cambridge:
553:
547:
543:
534:
531:
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526:
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521:
519:
516:
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511:
510:
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495:
490:
488:
484:
479:
475:
472:
468:
463:
461:
457:
452:
450:
446:
442:
438:
435:(abbreviated
434:
422:
415:
410:
393:
387:
380:
378:
375:
374:
347:
344:
340:
339:
334:
325:
320:
319:
316:
309:
295:
285:
284:
281:
274:
266:
262:
261:DTXSID5048344
258:
257:
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245:
241:
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233:
229:
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221:
220:
213:
209:
208:
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200:
196:
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191:
187:
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182:
181:
174:
170:
169:
167:
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162:
161:
154:
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149:
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134:
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83:
79:
78:
76:
73:
69:
68:
63:
55:
47:
43:
38:
34:
29:
25:
20:
942:
869:Deferoxamine
757:
754:Clin Toxicol
753:
743:
718:
714:
708:
683:
679:
673:
656:
652:
639:
614:
610:
604:
595:
591:
585:
577:
551:
546:
500:
491:
480:
476:
464:
453:
440:
436:
432:
431:
65:Identifiers
57:Other names
979:from market
897:Dexrazoxane
864:Deferiprone
859:Deferasirox
721:(1): 1–12.
659:(1): 8–12.
456:heavy metal
449:dimercaprol
336:Properties
1010:Categories
715:Toxicology
680:Toxicology
598:: 603–607.
539:References
377:Molar mass
232:086L82361J
144:ChemSpider
93:3D model (
72:CAS Number
1031:Antidotes
989:Phase III
977:Withdrawn
826:, others)
494:hemotoxic
133:CHEBI:888
909:Thallium
776:18568806
735:18077077
700:17408840
507:See also
460:polonium
441:Unithiol
190:Unithiol
665:9765315
631:2160791
414:what is
412: (
199:PubChem
82:74-61-3
1026:Thiols
972:WHO-EM
833:Copper
774:
733:
698:
663:
629:
570:
443:) are
409:verify
406:
382:188.27
315:SMILES
173:C10922
40:Names
938:BAPTA
926:Other
824:V03AC
280:InChI
124:ChEBI
95:JSmol
958:EGTA
953:DTPA
948:DMSA
943:DMPS
892:EDTA
879:Lead
851:Iron
772:PMID
731:PMID
696:PMID
661:PMID
627:PMID
568:ISBN
523:EDTA
437:DMPS
223:UNII
212:6321
184:MeSH
164:KEGG
153:6081
933:ALA
887:BAL
762:doi
723:doi
719:244
688:doi
684:234
657:287
619:doi
560:doi
249:EPA
202:CID
1012::
985::
818:/
770:.
758:46
756:.
752:.
729:.
717:.
694:.
682:.
655:.
651:.
625:.
615:30
613:.
596:22
594:.
576:.
566:.
822:(
808:e
801:t
794:v
778:.
764::
737:.
725::
702:.
690::
667:.
633:.
621::
562::
404:N
370:3
367:S
364:3
361:O
358:8
355:H
352:3
349:C
251:)
247:(
97:)
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