405:
450:: Referred to as "androgenic". Major subtype in males for activation of androgens from weaker forms (androstenedione to testosterone and DHEA to androstenediol). Also activates estrogens from weaker forms to a lesser extent (estrone to estradiol). This is essential for testicular but not ovarian production of testosterone. Not expressed in the ovaries, where another 17β-HSD subtype, likely HSD17B5, is expressed instead. Mutations are associated with
317:
4653:
429:
3β-androstanediol. Expressed primarily in the ovaries and placenta but also at lower levels in the breast epithelium. Major isoform of 17β-HSD in the granulosa cells of the ovaries. Mutations and associated deficiency have not been reported in humans. Knockout mice show altered ovarian sex steroid production, normal puberty, and severe subfertility due to defective luteinization and ovarian progesterone production.
439:
into active progesterone. Preferential activity on androgens. Expressed widely in the body including in the liver, intestines, lungs, pancreas, kidneys, endometrium, prostate, breast epithelium, placenta, and bone. Said to be responsible for 17β-HSD activity in the endometrium and placenta. Mutations
2947:
Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J (2011). "17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development".
3087:
Lin B, White JT, Ferguson C, Wang S, Vessella R, Bumgarner R, True LD, Hood L, Nelson PS (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium".
428:
to estriol). Catalyzes the final step in the biosynthesis of estrogens. Highly selective for estrogens; 100-fold higher affinity for estranes over androstanes. However, also catalyzes the conversion of DHEA into androstenediol. Recently, has been found to inactivate DHT into 3α- and
3205:
Perspicace E, Cozzoli L, Gargano EM, Hanke N, Carotti A, Hartmann RW, Marchais-Oberwinkler S (August 2014). "Novel, potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities".
1379:
Heart, skeletal muscle, liver, kidney, adrenal gland, testis, placenta, cerebellum, pancreas, stomach, small intestine, large intestine, trachea, lung, thyroid, esophagus, prostate, aorta, urinary bladder, spleen, skin, brain, ovary, breast, uterus,
568:: Is involved in cholesterol metabolism but is also thought to activate estrogens (estrone to estradiol) and inactivate androgens (dihydrotestosterone to androstanediol). Expressed in the ovaries, breasts, placenta, testes, prostate gland, and liver.
2536:
Kikuti YY, Tamiya G, Ando A, Chen L, Kimura M, Ferreira E, Tsuji K, Trowsdale J, Inoko H (June 1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes".
435:: Describable as "antiestrogenic" and "antiandrogenic". Major subtype for inactivation of estrogens and androgens into weaker forms (estradiol to estrone, testosterone to androstenedione, and androstenediol to DHEA). Also converts inactive
1606:
Dahm K, Breuer H (1964). "Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der
Nebenniere der Ratte" [Precipitation of a 17-Beta-Hydroxysteroid:Nad(P) Oxidoreductase from the Rat Adrenal Gland].
1266:
611:
1876:
Martel C, Rhéaume E, Takahashi M, Trudel C, Couët J, Luu-The V, Simard J, Labrie F (March 1992). "Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues".
1273:
618:
3029:
Ning X, Yang Y, Deng H, Zhang Q, Huang Y, Su Z, Fu Y, Xiang Q, Zhang S (2017). "Development of 17β-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy".
1956:"Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer"
574:: Inactivates estradiol, testosterone, and dihydrotestosterone, though can also convert estrone into estradiol. Expressed in the ovaries, testes, liver, pancreas, kidneys, and other tissues.
308:
The major reactions catalyzed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.
3334:
2181:"Hydroxysteroid (17β)-dehydrogenase 1-deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production"
4131:
2331:
1806:
Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Bélanger A (January 1997). "The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology".
184:
3156:
Xie YA, Lee W, Cai C, Gambin T, Nõupuu K, Sujirakul T, Ayuso C, Jhangiani S, Muzny D, Boerwinkle E, Gibbs R, Greenstein VC, Lupski JR, Tsang SH, Allikmets R (2014).
2292:
2084:
3327:
4297:
4126:
3320:
2994:
Soubhye J, Alard IC, van
Antwerpen P, Dufrasne F (2015). "Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the treatment of osteoporosis".
2572:
Lidén M, Tryggvason K, Eriksson U (December 2003). "Structure and function of retinol dehydrogenases of the short chain dehydrogenase/reductase family".
4287:
1549:
451:
3941:
1107:
Ovary, corpus luteum, uterus, placenta, liver, breast, testis, brain, adrenal gland, small intestine, lung, thymus, prostate, adipose tissue, others
440:
and associated congenital deficiency have not been reported in humans. However, local deficiency in expression of HSD17B2 has been associated with
873:
4181:
2222:"High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract"
2353:
Bulun SE, Cheng YH, Pavone ME, Yin P, Imir G, Utsunomiya H, Thung S, Xue Q, Marsh EE, Tokunaga H, Ishikawa H, Kurita T, Su EJ (January 2010).
931:
Liver, heart, prostate, testis, lung, skeletal muscle, kidney, pancreas, thymus, ovary, intestine, placenta, brain, spleen, colon, lymphocytes
2005:"17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production"
1726:"3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms"
203:
4198:
4269:
3967:
3312:
3975:
1260:
Liver, small intestine, colon, kidney, heart, brain, placenta, lung, ovary, testis, spleen, thymus, prostate, peripheral blood leukocytes
2609:"Fundus albipunctatus: review of the literature and report of a novel RDH5 gene mutation affecting the invariant tyrosine (p.Tyr175Phe)"
4216:
2607:
Skorczyk-Werner A, Pawłowski P, Michalczuk M, Warowicka A, Wawrocka A, Wicher K, Bakunowicz-Łazarczyk A, Krawczyński MR (August 2015).
4231:
4176:
3704:
3699:
4325:
3278:
4061:
3530:
2746:
Su W, Mao Z, Liu Y, Zhang X, Zhang W, Gustafsson J, Guan Y (2019). "Role of HSD17B13 in the liver physiology and pathophysiology".
1006:
Prostate, mammary gland, liver, kidney, lung, heart, small intestine, colon, uterus, testis, brain, skeletal muscle, adipose tissue
4004:
3476:
3117:"Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)"
196:
4116:
3894:
3644:
955:
550:
4693:
3934:
2845:
2325:
2286:
2179:
Hakkarainen J, Jokela H, Pakarinen P, Heikelä H, Kätkänaho L, Vandenput L, Ohlsson C, Zhang FP, Poutanen M (September 2015).
2163:
2078:
1931:
1860:
147:
4211:
4171:
3413:
2405:
Pierce SB, Walsh T, Chisholm KM, Lee MK, Thornton AM, Fiumara A, Opitz JM, Levy-Lahad E, Klevit RE, King MC (August 2010).
457:. Males with this condition have pseudohermaphroditism, while females are normal with normal androgen and estrogen levels.
4688:
4221:
4188:
3471:
3302:
2407:"Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome"
3691:
498:
4315:
4076:
3989:
2783:"Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis"
3780:
3716:
2106:
Andersson S, Moghrabi N (January 1997). "Physiology and molecular genetics of 17 beta-hydroxysteroid dehydrogenases".
1587:
525:
489:
470:
and steroid metabolism (specifically estrone to estradiol, for instance in the uterus). Mutations are associated with
4372:
4071:
3971:
937:
546:
471:
424:: Referred to as "estrogenic". Major subtype for activation of estrogens from weaker forms (estrone to estradiol and
4678:
3927:
3072:
Samson M, Labrie F, and Luu-The V (23 June 2012). "Characterization of Type 15 17β-Hydroxysteroid
Dehydrogenase".
4683:
3984:
3588:
3418:
2834:"4.02: Disorders of Sexual Development in Males: Molecular Genetics, Epigenetics, Gender Identity, and Cognition"
141:
4310:
4136:
3569:
123:
4528:
4121:
3904:
3492:
128:
3611:
3559:
3115:
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS (2002).
2497:"Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues"
1158:
Prostate, placenta, kidney, brain, cerebellum, heart, lung, small intestine, ovary, testis, adrenal, stomach
4149:
3342:
2840:. Vol. 4: Clinical Important Effects of Hormones on Brain and Behavior. Elsevier Science. p. 69.
4282:
4046:
3899:
3453:
208:
1333:
Liver, pancreas, intestine, kidney, adrenal gland, heart, lung, testis, ovary, placenta, sebaceous gland
116:
4643:
4051:
3158:"New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11"
3243:"Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1"
542:
436:
331:
4629:
4616:
4603:
4590:
4577:
4564:
4551:
4513:
4101:
3564:
3241:
Brozic P, Kocbek P, Sova M, Kristl J, Martens S, Adamski J, Gobec S, Lanisnik Rizner T (March 2009).
2659:
Yang SY, He XY, Miller D (2011). "Hydroxysteroid (17β) dehydrogenase X in human health and disease".
1164:
736:
554:
538:
51:
3919:
4523:
4477:
4420:
4091:
3958:
3466:
3306:
1488:
232:
144:
34:
68:
4425:
4249:
4056:
2833:
1923:
Estrogens and
Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens
1430:
Liver, bone marrow, lung, ovary, testis, kidney, skeletal muscle, brain, bladder, nasal epithelia
1174:
594:: Also known as 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD). Substrates include steroids,
247:
4141:
3954:
3535:
2355:"17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis"
2315:
1282:
340:
282:
2276:
2153:
1921:
1850:
408:
Distribution of 17β-HSD activities for formation of estradiol versus estrone in human tissues.
4446:
4365:
4334:
4096:
3994:
3497:
2904:
Mindnich R, Möller G, Adamski J (2004). "The role of 17 beta-hydroxysteroid dehydrogenases".
2068:
800:
2220:
Wang CT, Li CF, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH, Liao KM (2016).
659:
425:
389:
367:
267:
4518:
4111:
4106:
4066:
3669:
3550:
1582:
1535:
1215:
585:
537:
into the powerful androgen dihydrotestosterone in the prostate gland. Also involved into a
104:
375:
371:
8:
4482:
3999:
3540:
3242:
1314:
975:
363:
80:
46:
2861:
Moeller G, Adamski J (2009). "Integrated view on 17beta-hydroxysteroid dehydrogenases".
39:
4415:
3855:
3371:
3363:
3270:
3182:
3157:
3054:
2973:
2929:
2886:
2809:
2782:
2684:
2633:
2608:
2477:
2431:
2406:
2379:
2354:
2246:
2221:
2131:
2029:
2004:
1980:
1955:
1902:
1831:
626:
3741:
2585:
2119:
1819:
1783:
1766:
1742:
1725:
1701:
1684:
1660:
1643:
159:
4673:
4086:
4081:
3866:
3796:
3461:
3442:
3262:
3223:
3187:
3138:
3097:
3046:
3011:
2965:
2921:
2878:
2841:
2814:
2763:
2728:
2676:
2638:
2589:
2554:
2518:
2481:
2436:
2384:
2321:
2282:
2251:
2202:
2159:
2123:
2074:
2034:
1985:
1927:
1894:
1890:
1856:
1823:
1788:
1747:
1706:
1665:
1624:
944:
622:
475:
354:
135:
3274:
3058:
2977:
2933:
2890:
2135:
1906:
1835:
327:
17β-HSDs have been known to catalyze the following redox reactions of sex steroids:
4461:
4456:
4430:
4358:
4254:
4041:
3874:
3394:
3347:
3254:
3215:
3177:
3169:
3128:
3042:
3038:
3003:
2957:
2913:
2870:
2804:
2794:
2755:
2718:
2688:
2668:
2628:
2620:
2581:
2546:
2508:
2467:
2426:
2418:
2374:
2366:
2241:
2233:
2192:
2115:
2024:
2016:
1975:
1967:
1886:
1815:
1778:
1737:
1696:
1655:
1616:
404:
349:
2707:"Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders"
4508:
4492:
4405:
4259:
4244:
3626:
3219:
1084:
320:
290:
271:
263:
2961:
2723:
2706:
1620:
163:
4657:
4546:
4487:
3950:
3736:
3655:
3434:
2799:
2422:
655:
534:
507:
467:
286:
259:
179:
3258:
2917:
2874:
2759:
2672:
2624:
1971:
1565:
Some inhibitors of 17β-HSD type I have been identified, for example esters of
4667:
4451:
4410:
2513:
2496:
1685:"Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases"
1566:
1558:
Inhibitors of 17β-HSD type II are of interest for the potential treatment of
441:
154:
2472:
2455:
1251:
Fatty acids, bile acids, estrogens, androgens, progestogens, corticosteroids
654:
At least 7 of the 14 isoforms of 17β-HSD are involved in interconversion of
4400:
3636:
3266:
3227:
3191:
3142:
3133:
3116:
3101:
3050:
3015:
2969:
2925:
2882:
2818:
2767:
2732:
2680:
2642:
2606:
2593:
2550:
2440:
2388:
2370:
2255:
2206:
2038:
1989:
1792:
1710:
1669:
1628:
1559:
1139:
991:
595:
511:
358:
335:
294:
2558:
2522:
2127:
1898:
1827:
4624:
4559:
4395:
3752:
3664:
3579:
3512:
3423:
3405:
3355:
3173:
2197:
2180:
2020:
1751:
912:
689:
515:
821:
Liver, intestine, endometrium, placenta, pancreas, prostate, colon, bone
235:
92:
4202:
4154:
3522:
3343:
607:
603:
464:
278:
3007:
2237:
1498:
4598:
4572:
4273:
3949:
3860:
3827:
3681:
3603:
599:
384:
302:
251:
4159:
3114:
1767:"Purification and properties of a beta-hydroxysteroid dehydrogenase"
1052:
Liver, testis, lung, spleen, brain, ovary, kidney, adrenal, prostate
545:
to dihydrotestosterone by 3α-reduction of a metabolic intermediary,
4652:
3819:
3762:
3677:
3389:
2946:
1444:
1394:
1347:
1292:
1230:
1225:
1038:
648:
643:
638:
632:
591:
581:
2495:
Fomitcheva J, Baker ME, Anderson E, Lee GY, Aziz N (August 1998).
1919:
1274:
316:
4301:
4014:
3885:
3880:
3775:
3770:
3686:
3616:
3381:
3359:
2993:
2178:
1570:
1121:
1066:
1020:
887:
835:
782:
752:
729:
577:
571:
565:
521:
484:: Also known as aldo-keto reductase 1C3 (AKR1C3), encoded by the
481:
460:
447:
432:
421:
393:
380:
298:
275:
111:
2705:
Yang SY, He XY, Isaacs C, Dobkin C, Miller D, Philipp M (2014).
4611:
4381:
4339:
4235:
4034:
4029:
4024:
4019:
4009:
3806:
3801:
3729:
3724:
3351:
2260:
HSD17B2 has both anti-estrogenic and anti-androgenic functions.
867:
Testis, ovary, blood, saliva, skin, adipose tissue, brain, bone
191:
87:
75:
63:
966:
956:
4585:
4164:
3204:
3074:
Steroid
Hormone Biosynthesis & Metabolism (Translational)
2003:
Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX (April 2010).
816:
763:
255:
1875:
1474:
Liver, kidney, brain, gallbladder, breast, adrenal, placenta
827:
Breast cancer, prostate cancer, endometriosis, osteoporosis
580:: Also known as retinol dehydrogenase 5 (RDH5). Involved in
4132:
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1267:
671:
Comparison and characteristics of human 17β-HSD isoenzymes
635:: very little is known on the role/function of this iszyme.
514:. Also expressed in the prostate gland, mammary gland, and
506:
activity in addition to 17β-HSD activity. Expressed in the
99:
4350:
2494:
1849:
Brook CG, Truong D, Clayton P, Carroll W, Brown R (2011).
874:
463:: Also known as D-bifunctional protein (DBP). Involved in
1848:
1920:
Michael Oettel, Ekkehard
Schillinger (6 December 2012).
1550:
612:
499:
452:
3071:
2571:
1644:"The conversion of progesterone to androgens by testes"
533:
activity and catalyzes conversion of the weak androgen
526:
490:
3240:
2404:
2158:. Springer Science & Business Media. p. 549.
2002:
1926:. Springer Science & Business Media. p. 226.
1805:
4641:
2903:
2780:
1913:
768:
Ovary, endometrium, breast, brain, prostate, placenta
617:(also known as HSD10 disease or MHBD deficiency) and
3834:
3790:
3782:
3718:
3693:
3086:
2831:
2535:
1609:
4127:
Malate dehydrogenase (oxaloacetate-decarboxylating)
2352:
510:and may act as the "androgenic" 17β-HSD in ovarian
4288:Vitamin-K-epoxide reductase (warfarin-insensitive)
2704:
1953:
1723:
1279:Tooltip Mental retardation, X-linked, syndromic 10
997:Androgens, progestogens, estrogens, prostaglandins
3028:
2105:
2062:
2060:
2058:
2056:
2054:
2052:
2050:
2048:
1504:
1451:
1401:
1354:
1299:
1235:
1128:
1073:
1027:
901:
896:
842:
789:
737:
555:
4665:
3234:
3065:
2832:Zhu YS, Imperato-McGinley JL (9 November 2016).
2307:
1489:
970:
3155:
2989:
2987:
2700:
2698:
2654:
2652:
2400:
2398:
2313:
2066:
1949:
1947:
1945:
1943:
1175:
1098:Cholesterol, estrogens, androgens, progestogens
2860:
2147:
2145:
2045:
961:Tooltip Aldo-keto reductase family 1 member C3
938:
892:
774:Breast cancer, prostate cancer, endometriosis
341:
4366:
3935:
3328:
2745:
2453:
2270:
2268:
2219:
2067:Strauss JF, Barbieri RL (13 September 2013).
1764:
1724:Schultz RM, Groman EV, Engel LL (June 1977).
1682:
1515:
1412:
1365:
1310:
1195:
1093:
922:Fatty acids, bile acids, estrogens, androgens
853:
801:
3198:
3149:
3108:
3080:
3022:
2984:
2940:
2897:
2854:
2825:
2781:Bai R, Rebelo A, Kleeff J, Sunami Y (2021).
2695:
2658:
2649:
2600:
2565:
2395:
2346:
2314:Jameson JL, De Groot LJ (25 February 2015).
2213:
2172:
1996:
1940:
1209:Retina, liver, adipose tissue, blood, others
553:. May be involved in the pathophysiology of
2529:
2488:
2142:
2099:
1416:
1315:
976:
4373:
4359:
4217:D-lactate dehydrogenase (cytochrome c-553)
3942:
3928:
3335:
3321:
2320:. Elsevier Health Sciences. p. 2078.
2265:
2070:Yen and Jaffe's Reproductive Endocrinology
1869:
1842:
1799:
1605:
619:mental retardation, X-linked, syndromic 10
584:metabolism. Mutations are associated with
3305:at the U.S. National Library of Medicine
3303:3(or+17)beta-hydroxysteroid+dehydrogenase
3181:
3132:
2808:
2798:
2722:
2632:
2512:
2471:
2430:
2378:
2317:Endocrinology: Adult and Pediatric E-Book
2281:. Elsevier Health Sciences. p. 904.
2245:
2196:
2028:
1979:
1954:Hilborn E, Stål O, Jansson A (May 2017).
1782:
1741:
1700:
1659:
1641:
1548:Mutations in HSD17B3 are responsible for
4062:D-malate dehydrogenase (decarboxylating)
3531:Farnesyl-diphosphate farnesyltransferase
2073:. Elsevier Health Sciences. p. 82.
1852:Brook's Clinical Pediatric Endocrinology
1543:
504:Tooltip 20α-hydroxysteroid dehydrogenase
403:
399:
323:. 17β-HSD visible in bottom-left region.
315:
3477:Isopentenyl-diphosphate delta isomerase
3208:European Journal of Medicinal Chemistry
2151:
1085:
531:Tooltip 3α-hydroxysteroid dehydrogenase
495:Tooltip 3α-hydroxysteroid dehydrogenase
4666:
4117:Malate dehydrogenase (decarboxylating)
3895:Steroidogenic acute regulatory protein
2274:
1855:. John Wiley & Sons. p. 288.
1765:Talalay P, Dobson MM (December 1953).
1683:Marcus PI, Talalay P (February 1956).
4354:
3923:
3316:
621:(MRXS10), which are characterized by
4212:D-lactate dehydrogenase (cytochrome)
3247:Molecular and Cellular Endocrinology
2748:Molecular and Cellular Endocrinology
1246:
1140:
4222:Mannitol dehydrogenase (cytochrome)
3472:Pyrophosphomevalonate decarboxylase
3390:Acetyl-Coenzyme A acetyltransferase
2501:The Journal of Biological Chemistry
1771:The Journal of Biological Chemistry
1730:The Journal of Biological Chemistry
1689:The Journal of Biological Chemistry
1648:The Journal of Biological Chemistry
913:
690:
281:. This includes interconversion of
13:
4316:Quinoprotein glucose dehydrogenase
4077:Glycerol-3-phosphate dehydrogenase
3990:3-hydroxybutyryl-CoA dehydrogenase
2447:
2411:American Journal of Human Genetics
2278:Williams Textbook of Endocrinology
810:Estrogens, androgens, progestogens
478:(ovarian dysgenesis and deafness).
417:Genes coding for 17β-HSD include:
14:
4705:
4072:Glucose-6-phosphate dehydrogenase
3296:
3281:from the original on 4 March 2022
2359:Seminars in Reproductive Medicine
1465:Estrogens, androgens, fatty acids
1370:Fatty acids, estrogens, androgens
1149:Fatty acids, estrogens, androgens
742:Tooltip Short-chain dehydrogenase
560:Tooltip polycystic ovary syndrome
221:17β-Hydroxysteroid dehydrogenases
4651:
2155:Principles of Molecular Medicine
1494:Tooltip Retinol dehydrogenase 11
610:. Mutations are associated with
24:17β-Hydroxysteroid dehydrogenase
3985:3-hydroxyacyl-CoA dehydrogenase
3645:Cholesterol side-chain cleavage
3589:24-Dehydrocholesterol reductase
3419:3-hydroxybutyrate dehydrogenase
2774:
2739:
2456:"Alternative androgen pathways"
2334:from the original on 4 May 2024
2295:from the original on 4 May 2024
2087:from the original on 4 May 2024
1642:Lynn WS, Brown RH (June 1958).
1588:3α-Hydroxysteroid dehydrogenase
1529:Retina, prostate, brain, testis
1180:Tooltip Retinol dehydrogenase 5
1043:Retinoids, androgens, estrogens
1012:Breast cancer, prostate cancer
4311:Malate dehydrogenase (quinone)
4137:Phosphogluconate dehydrogenase
3570:7-Dehydrocholesterol reductase
3043:10.1016/j.steroids.2017.02.003
1758:
1717:
1676:
1635:
1599:
547:17α-hydroxydihydroprogesterone
346:Tooltip Dehydroepiandrosterone
1:
3905:Reverse cholesterol transport
3493:Dimethylallyltranstransferase
2950:J. Steroid Biochem. Mol. Biol
2711:J. Steroid Biochem. Mol. Biol
2586:10.1016/s0098-2997(03)00036-0
2574:Molecular Aspects of Medicine
2120:10.1016/s0039-128x(96)00173-0
1879:J. Steroid Biochem. Mol. Biol
1820:10.1016/S0039-128X(96)00174-2
1784:10.1016/S0021-9258(18)49226-5
1743:10.1016/S0021-9258(17)40319-X
1702:10.1016/S0021-9258(18)65833-8
1661:10.1016/S0021-9258(19)77419-5
1593:
806:Tooltip Endoplasmic reticulum
549:, into another intermediary,
4694:Steroid hormone biosynthesis
4150:Hydroxysteroid dehydrogenase
4122:Malate dehydrogenase (NADP+)
3220:10.1016/j.ejmech.2014.06.036
2838:Hormones, Brain and Behavior
2787:Lipids in Health and Disease
2454:Masiutin M, Yadav M (2023).
1891:10.1016/0960-0760(92)90390-5
311:
7:
4380:
4283:Vitamin K epoxide reductase
4052:Carbohydrate dehydrogenases
4047:Beta-Ketoacyl ACP reductase
3900:Cholesterol total synthesis
2962:10.1016/j.jsbmb.2010.12.013
2724:10.1016/j.jsbmb.2014.07.001
2613:Journal of Applied Genetics
2152:Jameson JL (13 July 1998).
1621:10.1515/bchm2.1964.336.1.63
1576:
1569:and various flavones (e.g.
1480:Breast cancer (prognostic)
1320:Tooltip Extracellular space
981:Tooltip Aldo-keto reductase
665:
551:17α-hydroxyallopregnanolone
10:
4710:
4689:Enzymes of known structure
3612:Cholesterol 7α-hydroxylase
3560:Lanosterol 14α-demethylase
2800:10.1186/s12944-021-01476-y
2423:10.1016/j.ajhg.2010.07.007
4537:
4529:Michaelis–Menten kinetics
4501:
4470:
4439:
4388:
4324:
4296:
4268:
4230:
4197:
4102:L-threonine dehydrogenase
3966:
3848:
3817:
3760:
3750:
3653:
3634:
3625:
3601:
3578:
3565:Sterol-C5-desaturase-like
3549:
3520:
3510:
3485:
3451:
3432:
3404:
3379:
3370:
3259:10.1016/j.mce.2008.09.004
2918:10.1016/j.mce.2003.12.006
2875:10.1016/j.mce.2008.10.040
2760:10.1016/j.mce.2018.10.014
2673:10.1016/j.mce.2011.06.011
2625:10.1007/s13353-015-0281-x
1972:10.18632/oncotarget.15547
1165:Polycystic kidney disease
240:17-ketosteroid reductases
202:
190:
178:
173:
169:
153:
134:
122:
110:
98:
86:
74:
62:
57:
45:
33:
28:
23:
4421:Diffusion-limited enzyme
4092:Isocitrate dehydrogenase
3467:Phosphomevalonate kinase
3307:Medical Subject Headings
2514:10.1074/jbc.273.35.22664
412:
4679:NADPH-dependent enzymes
4250:L-gulonolactone oxidase
4057:Carnitine dehydrogenase
3955:alcohol oxidoreductases
2836:. In Lightman S (ed.).
2460:WikiJournal of Medicine
2009:Molecular Endocrinology
1090:Tooltip Plasma membrane
1055:Selectively distributed
824:Selectively distributed
706:Substrate specificities
543:17α-hydroxyprogesterone
437:20α-hydroxyprogesterone
332:20α-Hydroxyprogesterone
248:alcohol oxidoreductases
4684:NADH-dependent enzymes
4142:Sorbitol dehydrogenase
3536:Squalene monooxygenase
3134:10.1074/jbc.M202588200
2551:10.1006/geno.1997.4745
2371:10.1055/s-0029-1242992
409:
324:
4514:Eadie–Hofstee diagram
4447:Allosteric regulation
4335:Choline dehydrogenase
4097:Lactate dehydrogenase
3995:Alcohol dehydrogenase
3617:Sterol 27-hydroxylase
3498:Geranyl pyrophosphate
2906:Mol. Cell. Endocrinol
2863:Mol. Cell. Endocrinol
2661:Mol. Cell. Endocrinol
2473:10.15347/WJM/2023.003
1544:Clinical significance
1206:Reduction / oxidation
407:
400:Activity distribution
319:
4524:Lineweaver–Burk plot
4112:Malate dehydrogenase
4107:L-xylulose reductase
4067:DXP reductoisomerase
3551:7-Dehydrocholesterol
2198:10.1096/fj.14-269035
2021:10.1210/me.2009-0468
1583:Steroidogenic enzyme
1536:Retinitis pigmentosa
1520:Retinoids, androgens
1324:Estrogens, androgens
1216:Fundus albipunctatus
1145:Tooltip Mitochondria
712:Catalytic preference
586:fundus albipunctatus
488:gene in humans. Has
4000:Aldo-keto reductase
3541:Lanosterol synthase
1966:(18): 30552–30562.
1553:type III deficiency
1433:Strongly restricted
1283:Alzheimer's disease
918:Tooltip Peroxisomes
870:Strongly restricted
771:Strongly restricted
715:Tissue distribution
695:Tooltip Amino acids
672:
660:17β-hydroxysteroids
455:type III deficiency
364:Dihydrotestosterone
268:17β-hydroxysteroids
4483:Enzyme superfamily
4416:Enzyme promiscuity
3856:Steroid metabolism
3372:Mevalonate pathway
3364:steroid metabolism
3174:10.1093/hmg/ddu291
1477:Widely distributed
1161:Widely distributed
1110:Widely distributed
947:, prostate cancer
879:, prostate cancer
718:Expression profile
709:Preferred cofactor
670:
627:mental retardation
426:16α-hydroxyestrone
410:
390:16α-Hydroxyestrone
368:5α-Androstanedione
325:
246:), are a group of
4639:
4638:
4348:
4347:
4328:: other acceptors
4304:/similar acceptor
4087:IMP dehydrogenase
4082:HMG-CoA reductase
3917:
3916:
3913:
3912:
3867:Steroid sulfatase
3844:
3843:
3597:
3596:
3506:
3505:
3462:Mevalonate kinase
3443:HMG-CoA reductase
3008:10.4155/fmc.15.74
2847:978-0-12-803608-2
2327:978-0-323-32195-2
2288:978-0-323-29738-7
2275:Melmed S (2016).
2238:10.7150/jca.16777
2232:(15): 2221–2230.
2226:Journal of Cancer
2165:978-1-59259-726-0
2080:978-1-4557-2758-2
1933:978-3-642-58616-3
1862:978-1-4443-1673-5
1541:
1540:
1336:Nearly ubiquitous
1263:Nearly ubiquitous
1009:Nearly ubiquitous
945:Perrault syndrome
703:Cellular location
623:neurodegeneration
615:type X deficiency
476:Perrault syndrome
376:3β-Androstanediol
372:3α-Androstanediol
218:
217:
214:
213:
117:metabolic pathway
4701:
4656:
4655:
4647:
4519:Hanes–Woolf plot
4462:Enzyme activator
4457:Enzyme inhibitor
4431:Enzyme catalysis
4375:
4368:
4361:
4352:
4351:
4255:Xanthine oxidase
4042:Aldose reductase
3944:
3937:
3930:
3921:
3920:
3875:sulfotransferase
3836:
3792:
3784:
3758:
3757:
3720:
3695:
3632:
3631:
3518:
3517:
3397:(regulated step)
3395:HMG-CoA synthase
3377:
3376:
3348:lipid metabolism
3337:
3330:
3323:
3314:
3313:
3291:
3290:
3288:
3286:
3238:
3232:
3231:
3202:
3196:
3195:
3185:
3153:
3147:
3146:
3136:
3127:(32): 28909–15.
3112:
3106:
3105:
3084:
3078:
3077:
3069:
3063:
3062:
3026:
3020:
3019:
2991:
2982:
2981:
2944:
2938:
2937:
2901:
2895:
2894:
2858:
2852:
2851:
2829:
2823:
2822:
2812:
2802:
2778:
2772:
2771:
2743:
2737:
2736:
2726:
2702:
2693:
2692:
2656:
2647:
2646:
2636:
2604:
2598:
2597:
2569:
2563:
2562:
2533:
2527:
2526:
2516:
2507:(35): 22664–71.
2492:
2486:
2485:
2475:
2451:
2445:
2444:
2434:
2402:
2393:
2392:
2382:
2350:
2344:
2343:
2341:
2339:
2311:
2305:
2304:
2302:
2300:
2272:
2263:
2262:
2249:
2217:
2211:
2210:
2200:
2176:
2170:
2169:
2149:
2140:
2139:
2103:
2097:
2096:
2094:
2092:
2064:
2043:
2042:
2032:
2000:
1994:
1993:
1983:
1951:
1938:
1937:
1917:
1911:
1910:
1885:(3–8): 597–603.
1873:
1867:
1866:
1846:
1840:
1839:
1803:
1797:
1796:
1786:
1762:
1756:
1755:
1745:
1721:
1715:
1714:
1704:
1680:
1674:
1673:
1663:
1639:
1633:
1632:
1603:
1552:
1517:
1506:
1500:
1495:
1491:
1453:
1418:
1414:
1403:
1367:
1356:
1321:
1317:
1312:
1301:
1280:
1276:
1269:
1248:
1237:
1232:
1197:
1181:
1177:
1146:
1142:
1130:
1095:
1091:
1087:
1075:
1029:
982:
978:
972:
968:
962:
958:
940:
919:
915:
903:
898:
894:
876:
855:
844:
807:
803:
791:
743:
739:
696:
692:
673:
669:
614:
561:
557:
539:backdoor pathway
532:
528:
505:
501:
496:
492:
454:
347:
343:
171:
170:
21:
20:
16:Class of enzymes
4709:
4708:
4704:
4703:
4702:
4700:
4699:
4698:
4664:
4663:
4662:
4650:
4642:
4640:
4635:
4547:Oxidoreductases
4533:
4509:Enzyme kinetics
4497:
4493:List of enzymes
4466:
4435:
4406:Catalytic triad
4384:
4379:
4349:
4344:
4320:
4292:
4264:
4260:Alcohol oxidase
4245:Glucose oxidase
4226:
4193:
3962:
3951:Oxidoreductases
3948:
3918:
3909:
3849:Other/ungrouped
3840:
3813:
3771:17α-Hydroxylase
3746:
3742:11β-Hydroxylase
3687:17α-Hydroxylase
3656:corticosteroids
3649:
3627:Steroidogenesis
3621:
3593:
3574:
3545:
3502:
3481:
3447:
3428:
3400:
3366:
3341:
3299:
3294:
3284:
3282:
3253:(1–2): 229–34.
3239:
3235:
3203:
3199:
3168:(21): 5774–80.
3162:Hum. Mol. Genet
3154:
3150:
3113:
3109:
3085:
3081:
3070:
3066:
3027:
3023:
3002:(11): 1431–56.
2996:Future Med Chem
2992:
2985:
2945:
2941:
2902:
2898:
2859:
2855:
2848:
2830:
2826:
2779:
2775:
2744:
2740:
2703:
2696:
2657:
2650:
2605:
2601:
2570:
2566:
2534:
2530:
2493:
2489:
2452:
2448:
2403:
2396:
2351:
2347:
2337:
2335:
2328:
2312:
2308:
2298:
2296:
2289:
2273:
2266:
2218:
2214:
2177:
2173:
2166:
2150:
2143:
2104:
2100:
2090:
2088:
2081:
2065:
2046:
2001:
1997:
1952:
1941:
1934:
1918:
1914:
1874:
1870:
1863:
1847:
1843:
1804:
1800:
1763:
1759:
1736:(11): 3775–83.
1722:
1718:
1681:
1677:
1640:
1636:
1604:
1600:
1596:
1579:
1546:
1493:
1319:
1278:
1179:
1144:
1089:
980:
960:
917:
805:
741:
694:
668:
656:17-ketosteroids
629:, respectively.
598:, fatty acids,
559:
530:
503:
494:
415:
402:
355:Androstenedione
345:
321:Steroidogenesis
314:
291:androstenedione
272:steroidogenesis
264:dehydrogenation
260:17-ketosteroids
17:
12:
11:
5:
4707:
4697:
4696:
4691:
4686:
4681:
4676:
4661:
4660:
4637:
4636:
4634:
4633:
4620:
4607:
4594:
4581:
4568:
4555:
4541:
4539:
4535:
4534:
4532:
4531:
4526:
4521:
4516:
4511:
4505:
4503:
4499:
4498:
4496:
4495:
4490:
4485:
4480:
4474:
4472:
4471:Classification
4468:
4467:
4465:
4464:
4459:
4454:
4449:
4443:
4441:
4437:
4436:
4434:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4392:
4390:
4386:
4385:
4378:
4377:
4370:
4363:
4355:
4346:
4345:
4343:
4342:
4337:
4331:
4329:
4322:
4321:
4319:
4318:
4313:
4307:
4305:
4294:
4293:
4291:
4290:
4285:
4279:
4277:
4266:
4265:
4263:
4262:
4257:
4252:
4247:
4241:
4239:
4228:
4227:
4225:
4224:
4219:
4214:
4208:
4206:
4195:
4194:
4192:
4191:
4186:
4185:
4184:
4179:
4169:
4168:
4167:
4162:
4145:
4144:
4139:
4134:
4129:
4124:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4069:
4064:
4059:
4054:
4049:
4044:
4039:
4038:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
3997:
3992:
3987:
3981:
3979:
3964:
3963:
3947:
3946:
3939:
3932:
3924:
3915:
3914:
3911:
3910:
3908:
3907:
3902:
3897:
3891:
3890:
3889:
3888:
3883:
3871:
3870:
3869:
3852:
3850:
3846:
3845:
3842:
3841:
3839:
3838:
3830:
3824:
3822:
3815:
3814:
3812:
3811:
3810:
3809:
3804:
3794:
3786:
3778:
3773:
3767:
3765:
3755:
3748:
3747:
3745:
3744:
3739:
3737:21-Hydroxylase
3734:
3733:
3732:
3727:
3710:
3709:
3708:
3707:
3702:
3689:
3673:
3672:
3670:18-Hydroxylase
3660:
3658:
3651:
3650:
3648:
3647:
3641:
3639:
3629:
3623:
3622:
3620:
3619:
3614:
3608:
3606:
3599:
3598:
3595:
3594:
3592:
3591:
3585:
3583:
3576:
3575:
3573:
3572:
3567:
3562:
3556:
3554:
3547:
3546:
3544:
3543:
3538:
3533:
3527:
3525:
3515:
3508:
3507:
3504:
3503:
3501:
3500:
3495:
3489:
3487:
3483:
3482:
3480:
3479:
3474:
3469:
3464:
3458:
3456:
3449:
3448:
3446:
3445:
3439:
3437:
3435:Mevalonic acid
3430:
3429:
3427:
3426:
3421:
3416:
3410:
3408:
3402:
3401:
3399:
3398:
3392:
3386:
3384:
3374:
3368:
3367:
3340:
3339:
3332:
3325:
3317:
3311:
3310:
3298:
3297:External links
3295:
3293:
3292:
3233:
3197:
3148:
3107:
3079:
3064:
3021:
2983:
2956:(1–2): 66–82.
2939:
2896:
2853:
2846:
2824:
2773:
2738:
2694:
2648:
2599:
2564:
2528:
2487:
2446:
2394:
2345:
2326:
2306:
2287:
2264:
2212:
2191:(9): 3806–16.
2171:
2164:
2141:
2098:
2079:
2044:
1995:
1939:
1932:
1912:
1868:
1861:
1841:
1798:
1757:
1716:
1675:
1654:(2): 1015–30.
1634:
1597:
1595:
1592:
1591:
1590:
1585:
1578:
1575:
1545:
1542:
1539:
1538:
1533:
1530:
1527:
1524:
1521:
1518:
1513:
1510:
1507:
1502:
1496:
1486:
1482:
1481:
1478:
1475:
1472:
1469:
1466:
1463:
1460:
1457:
1454:
1449:
1447:
1442:
1438:
1437:
1434:
1431:
1428:
1425:
1422:
1419:
1410:
1407:
1404:
1399:
1397:
1392:
1388:
1387:
1384:
1381:
1377:
1374:
1371:
1368:
1363:
1360:
1357:
1352:
1350:
1345:
1341:
1340:
1337:
1334:
1331:
1328:
1325:
1322:
1308:
1305:
1302:
1297:
1295:
1290:
1286:
1285:
1264:
1261:
1258:
1255:
1252:
1249:
1244:
1241:
1238:
1233:
1228:
1223:
1219:
1218:
1213:
1210:
1207:
1204:
1201:
1198:
1193:
1190:
1187:
1185:
1182:
1172:
1168:
1167:
1162:
1159:
1156:
1153:
1150:
1147:
1137:
1134:
1131:
1126:
1124:
1119:
1115:
1114:
1113:Breast cancer
1111:
1108:
1105:
1102:
1099:
1096:
1082:
1079:
1076:
1071:
1069:
1064:
1060:
1059:
1056:
1053:
1050:
1047:
1044:
1041:
1036:
1033:
1030:
1025:
1023:
1018:
1014:
1013:
1010:
1007:
1004:
1001:
998:
995:
989:
986:
983:
973:
963:
953:
949:
948:
935:
932:
929:
926:
923:
920:
910:
907:
904:
899:
890:
885:
881:
880:
871:
868:
865:
862:
859:
856:
851:
848:
845:
840:
838:
833:
829:
828:
825:
822:
819:
814:
811:
808:
798:
795:
792:
787:
785:
780:
776:
775:
772:
769:
766:
761:
758:
755:
750:
747:
744:
734:
732:
727:
723:
722:
719:
716:
713:
710:
707:
704:
701:
698:
686:
683:
680:
677:
667:
664:
652:
651:
646:
641:
636:
630:
589:
575:
569:
563:
535:androstanediol
519:
508:adrenal cortex
479:
472:DBP deficiency
458:
445:
430:
414:
411:
401:
398:
397:
396:
387:
378:
361:
352:
350:Androstenediol
338:
313:
310:
287:androstenediol
216:
215:
212:
211:
206:
200:
199:
194:
188:
187:
182:
176:
175:
167:
166:
157:
151:
150:
139:
132:
131:
126:
120:
119:
114:
108:
107:
102:
96:
95:
90:
84:
83:
78:
72:
71:
66:
60:
59:
55:
54:
49:
43:
42:
37:
31:
30:
26:
25:
15:
9:
6:
4:
3:
2:
4706:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4671:
4669:
4659:
4654:
4649:
4648:
4645:
4631:
4627:
4626:
4621:
4618:
4614:
4613:
4608:
4605:
4601:
4600:
4595:
4592:
4588:
4587:
4582:
4579:
4575:
4574:
4569:
4566:
4562:
4561:
4556:
4553:
4549:
4548:
4543:
4542:
4540:
4536:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4506:
4504:
4500:
4494:
4491:
4489:
4488:Enzyme family
4486:
4484:
4481:
4479:
4476:
4475:
4473:
4469:
4463:
4460:
4458:
4455:
4453:
4452:Cooperativity
4450:
4448:
4445:
4444:
4442:
4438:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4411:Oxyanion hole
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4393:
4391:
4387:
4383:
4376:
4371:
4369:
4364:
4362:
4357:
4356:
4353:
4341:
4338:
4336:
4333:
4332:
4330:
4327:
4323:
4317:
4314:
4312:
4309:
4308:
4306:
4303:
4299:
4295:
4289:
4286:
4284:
4281:
4280:
4278:
4275:
4271:
4267:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4242:
4240:
4237:
4233:
4229:
4223:
4220:
4218:
4215:
4213:
4210:
4209:
4207:
4204:
4200:
4196:
4190:
4187:
4183:
4180:
4178:
4175:
4174:
4173:
4170:
4166:
4163:
4161:
4158:
4157:
4156:
4153:
4151:
4147:
4146:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4002:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3982:
3980:
3977:
3973:
3969:
3965:
3960:
3956:
3952:
3945:
3940:
3938:
3933:
3931:
3926:
3925:
3922:
3906:
3903:
3901:
3898:
3896:
3893:
3892:
3887:
3884:
3882:
3879:
3878:
3877:
3876:
3872:
3868:
3865:
3864:
3863:
3862:
3857:
3854:
3853:
3851:
3847:
3837:
3831:
3829:
3826:
3825:
3823:
3821:
3816:
3808:
3805:
3803:
3800:
3799:
3798:
3795:
3793:
3787:
3785:
3779:
3777:
3774:
3772:
3769:
3768:
3766:
3764:
3759:
3756:
3754:
3749:
3743:
3740:
3738:
3735:
3731:
3728:
3726:
3723:
3722:
3721:
3715:
3712:
3711:
3706:
3703:
3701:
3698:
3697:
3696:
3690:
3688:
3685:
3683:
3679:
3675:
3674:
3671:
3668:
3666:
3662:
3661:
3659:
3657:
3652:
3646:
3643:
3642:
3640:
3638:
3633:
3630:
3628:
3624:
3618:
3615:
3613:
3610:
3609:
3607:
3605:
3600:
3590:
3587:
3586:
3584:
3581:
3577:
3571:
3568:
3566:
3563:
3561:
3558:
3557:
3555:
3552:
3548:
3542:
3539:
3537:
3534:
3532:
3529:
3528:
3526:
3524:
3519:
3516:
3514:
3509:
3499:
3496:
3494:
3491:
3490:
3488:
3484:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3459:
3457:
3455:
3450:
3444:
3441:
3440:
3438:
3436:
3431:
3425:
3422:
3420:
3417:
3415:
3414:HMG-CoA lyase
3412:
3411:
3409:
3407:
3403:
3396:
3393:
3391:
3388:
3387:
3385:
3383:
3378:
3375:
3373:
3369:
3365:
3361:
3357:
3353:
3349:
3345:
3338:
3333:
3331:
3326:
3324:
3319:
3318:
3315:
3308:
3304:
3301:
3300:
3280:
3276:
3272:
3268:
3264:
3260:
3256:
3252:
3248:
3244:
3237:
3229:
3225:
3221:
3217:
3213:
3209:
3201:
3193:
3189:
3184:
3179:
3175:
3171:
3167:
3163:
3159:
3152:
3144:
3140:
3135:
3130:
3126:
3122:
3121:J. Biol. Chem
3118:
3111:
3103:
3099:
3096:(4): 1611–8.
3095:
3091:
3083:
3075:
3068:
3060:
3056:
3052:
3048:
3044:
3040:
3036:
3032:
3025:
3017:
3013:
3009:
3005:
3001:
2997:
2990:
2988:
2979:
2975:
2971:
2967:
2963:
2959:
2955:
2951:
2943:
2935:
2931:
2927:
2923:
2919:
2915:
2912:(1–2): 7–20.
2911:
2907:
2900:
2892:
2888:
2884:
2880:
2876:
2872:
2869:(1–2): 7–19.
2868:
2864:
2857:
2849:
2843:
2839:
2835:
2828:
2820:
2816:
2811:
2806:
2801:
2796:
2792:
2788:
2784:
2777:
2769:
2765:
2761:
2757:
2753:
2749:
2742:
2734:
2730:
2725:
2720:
2716:
2712:
2708:
2701:
2699:
2690:
2686:
2682:
2678:
2674:
2670:
2666:
2662:
2655:
2653:
2644:
2640:
2635:
2630:
2626:
2622:
2619:(3): 317–27.
2618:
2614:
2610:
2603:
2595:
2591:
2587:
2583:
2579:
2575:
2568:
2560:
2556:
2552:
2548:
2545:(3): 422–35.
2544:
2540:
2532:
2524:
2520:
2515:
2510:
2506:
2502:
2498:
2491:
2483:
2479:
2474:
2469:
2465:
2461:
2457:
2450:
2442:
2438:
2433:
2428:
2424:
2420:
2416:
2412:
2408:
2401:
2399:
2390:
2386:
2381:
2376:
2372:
2368:
2364:
2360:
2356:
2349:
2333:
2329:
2323:
2319:
2318:
2310:
2294:
2290:
2284:
2280:
2279:
2271:
2269:
2261:
2257:
2253:
2248:
2243:
2239:
2235:
2231:
2227:
2223:
2216:
2208:
2204:
2199:
2194:
2190:
2186:
2185:FASEB Journal
2182:
2175:
2167:
2161:
2157:
2156:
2148:
2146:
2137:
2133:
2129:
2125:
2121:
2117:
2113:
2109:
2102:
2086:
2082:
2076:
2072:
2071:
2063:
2061:
2059:
2057:
2055:
2053:
2051:
2049:
2040:
2036:
2031:
2026:
2022:
2018:
2015:(4): 832–45.
2014:
2010:
2006:
1999:
1991:
1987:
1982:
1977:
1973:
1969:
1965:
1961:
1957:
1950:
1948:
1946:
1944:
1935:
1929:
1925:
1924:
1916:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1880:
1872:
1864:
1858:
1854:
1853:
1845:
1837:
1833:
1829:
1825:
1821:
1817:
1814:(1): 148–58.
1813:
1809:
1802:
1794:
1790:
1785:
1780:
1777:(2): 823–37.
1776:
1772:
1768:
1761:
1753:
1749:
1744:
1739:
1735:
1731:
1727:
1720:
1712:
1708:
1703:
1698:
1695:(2): 661–74.
1694:
1690:
1686:
1679:
1671:
1667:
1662:
1657:
1653:
1649:
1645:
1638:
1630:
1626:
1622:
1618:
1614:
1611:(in German).
1610:
1602:
1598:
1589:
1586:
1584:
1581:
1580:
1574:
1572:
1568:
1567:cinnamic acid
1563:
1561:
1556:
1554:
1537:
1534:
1531:
1528:
1525:
1522:
1519:
1514:
1511:
1508:
1503:
1497:
1492:
1487:
1484:
1483:
1479:
1476:
1473:
1470:
1467:
1464:
1461:
1458:
1455:
1450:
1448:
1446:
1443:
1440:
1439:
1435:
1432:
1429:
1426:
1423:
1420:
1411:
1408:
1405:
1400:
1398:
1396:
1393:
1390:
1389:
1385:
1382:
1378:
1375:
1372:
1369:
1364:
1361:
1358:
1353:
1351:
1349:
1346:
1343:
1342:
1338:
1335:
1332:
1329:
1326:
1323:
1318:
1309:
1306:
1303:
1298:
1296:
1294:
1291:
1288:
1287:
1284:
1277:
1271:
1265:
1262:
1259:
1256:
1253:
1250:
1245:
1242:
1239:
1234:
1229:
1227:
1224:
1221:
1220:
1217:
1214:
1211:
1208:
1205:
1202:
1199:
1194:
1191:
1188:
1186:
1183:
1178:
1173:
1170:
1169:
1166:
1163:
1160:
1157:
1154:
1151:
1148:
1143:
1138:
1135:
1132:
1127:
1125:
1123:
1120:
1117:
1116:
1112:
1109:
1106:
1103:
1100:
1097:
1088:
1083:
1080:
1077:
1072:
1070:
1068:
1065:
1062:
1061:
1057:
1054:
1051:
1048:
1045:
1042:
1040:
1037:
1034:
1031:
1026:
1024:
1022:
1019:
1016:
1015:
1011:
1008:
1005:
1002:
999:
996:
993:
990:
987:
984:
979:
974:
964:
959:
954:
951:
950:
946:
942:
936:
933:
930:
927:
924:
921:
916:
911:
908:
905:
900:
891:
889:
886:
883:
882:
878:
872:
869:
866:
863:
860:
857:
852:
849:
846:
841:
839:
837:
834:
831:
830:
826:
823:
820:
818:
815:
812:
809:
804:
799:
796:
793:
788:
786:
784:
781:
778:
777:
773:
770:
767:
765:
762:
759:
756:
754:
751:
748:
745:
740:
735:
733:
731:
728:
725:
724:
720:
717:
714:
711:
708:
705:
702:
700:Gene location
699:
693:
687:
684:
681:
678:
675:
674:
663:
661:
657:
650:
647:
645:
642:
640:
637:
634:
631:
628:
624:
620:
616:
609:
605:
601:
597:
596:neurosteroids
593:
590:
587:
583:
579:
576:
573:
570:
567:
564:
558:
552:
548:
544:
540:
536:
529:
523:
520:
517:
513:
509:
502:
493:
487:
483:
480:
477:
473:
469:
466:
462:
459:
456:
449:
446:
443:
442:endometriosis
438:
434:
431:
427:
423:
420:
419:
418:
406:
395:
391:
388:
386:
382:
379:
377:
373:
369:
365:
362:
360:
356:
353:
351:
344:
339:
337:
333:
330:
329:
328:
322:
318:
309:
306:
304:
300:
296:
292:
288:
284:
280:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
234:
230:
226:
222:
210:
207:
205:
201:
198:
195:
193:
189:
186:
183:
181:
177:
172:
168:
165:
161:
158:
156:
155:Gene Ontology
152:
149:
146:
143:
140:
137:
133:
130:
127:
125:
121:
118:
115:
113:
109:
106:
103:
101:
97:
94:
93:NiceZyme view
91:
89:
85:
82:
79:
77:
73:
70:
67:
65:
61:
56:
53:
50:
48:
44:
41:
38:
36:
32:
27:
22:
19:
4625:Translocases
4622:
4609:
4596:
4583:
4570:
4560:Transferases
4557:
4544:
4401:Binding site
4148:
3873:
3859:
3832:
3797:5α-Reductase
3788:
3753:sex hormones
3713:
3676:
3663:
3637:pregnenolone
3283:. Retrieved
3250:
3246:
3236:
3211:
3207:
3200:
3165:
3161:
3151:
3124:
3120:
3110:
3093:
3089:
3082:
3073:
3067:
3034:
3030:
3024:
2999:
2995:
2953:
2949:
2942:
2909:
2905:
2899:
2866:
2862:
2856:
2837:
2827:
2790:
2786:
2776:
2751:
2747:
2741:
2714:
2710:
2667:(1–2): 1–6.
2664:
2660:
2616:
2612:
2602:
2580:(6): 403–9.
2577:
2573:
2567:
2542:
2538:
2531:
2504:
2500:
2490:
2463:
2459:
2449:
2417:(2): 282–8.
2414:
2410:
2365:(1): 44–50.
2362:
2358:
2348:
2336:. Retrieved
2316:
2309:
2297:. Retrieved
2277:
2259:
2229:
2225:
2215:
2188:
2184:
2174:
2154:
2114:(1): 143–7.
2111:
2107:
2101:
2089:. Retrieved
2069:
2012:
2008:
1998:
1963:
1959:
1922:
1915:
1882:
1878:
1871:
1851:
1844:
1811:
1807:
1801:
1774:
1770:
1760:
1733:
1729:
1719:
1692:
1688:
1678:
1651:
1647:
1637:
1612:
1608:
1601:
1564:
1560:osteoporosis
1557:
1547:
653:
516:Leydig cells
512:thecal cells
485:
416:
359:Testosterone
336:Progesterone
326:
307:
295:testosterone
243:
239:
228:
224:
220:
219:
81:BRENDA entry
18:
4396:Active site
4276:as acceptor
3776:17,20-Lyase
3665:aldosterone
3580:Desmosterol
3513:cholesterol
3424:Thiophorase
3406:Ketogenesis
3356:cholesterol
2754:: 119–125.
760:NADH, NADPH
608:xenobiotics
468:β-oxidation
69:IntEnz view
29:Identifiers
4668:Categories
4599:Isomerases
4573:Hydrolases
4440:Regulation
4203:cytochrome
3604:Bile acids
3523:lanosterol
3358:synthesis
3344:Metabolism
3214:: 317–37.
3090:Cancer Res
2717:: 460–72.
1960:Oncotarget
1594:References
1512:14q23-24.3
1501:, HSD17B15
1427:Oxidation?
1383:Ubiquitous
1270:deficiency
941:deficiency
934:Ubiquitous
877:deficiency
721:Pathology
604:isoleucine
600:bile acids
465:fatty acid
279:metabolism
138:structures
105:KEGG entry
52:9015-81-0
4478:EC number
4274:disulfide
3861:sulfatase
3828:Aromatase
3820:estrogens
3763:androgens
3682:cortisone
3037:: 10–16.
2793:(1): 58.
2482:257943362
1526:Reduction
1471:Oxidation
1376:Reduction
1330:Oxidation
1268:17β-HSD10
1257:Oxidation
1200:Retinoids
1155:Oxidation
1104:Reduction
1049:Oxidation
1039:Endosomes
1003:Reduction
994:, cytosol
965:HSD17B5,
928:Oxidation
864:Reduction
858:Androgens
817:Oxidation
764:Reduction
757:Estrogens
679:Gene name
385:Estradiol
312:Reactions
303:estradiol
256:reduction
58:Databases
4674:EC 1.1.1
4502:Kinetics
4426:Cofactor
4389:Activity
4238:acceptor
4205:acceptor
4182:11β-HSD2
4177:11β-HSD1
3978:acceptor
3678:cortisol
3486:Geranyl-
3279:Archived
3275:26950431
3267:18835421
3228:24974351
3192:24916380
3143:12036956
3102:11245473
3059:32062736
3051:28267564
3031:Steroids
3016:26230882
2978:23767100
2970:21193039
2934:26877571
2926:15130507
2891:30321495
2883:19027824
2819:34078402
2768:30365983
2733:25007702
2681:21708223
2643:25820994
2594:14585311
2539:Genomics
2441:20673864
2389:20108182
2332:Archived
2293:Archived
2256:27994658
2207:26018678
2136:54341481
2108:Steroids
2085:Archived
2039:20172961
1990:28430630
1907:54325300
1836:54365519
1808:Steroids
1793:13129261
1711:13295221
1670:13549484
1629:14214322
1615:: 63–8.
1577:See also
1459:19q13.33
1445:HSD17B14
1395:HSD17B13
1348:HSD17B12
1293:HSD17B11
1226:HSD17B10
1203:NADH/NAD
875:17β-HSD3
682:Synonyms
666:Overview
649:HSD17B14
644:HSD17B13
639:HSD17B12
633:HSD17B11
592:HSD17B10
582:retinoid
262:and the
252:catalyze
238:), also
236:1.1.1.51
209:proteins
197:articles
185:articles
142:RCSB PDB
40:1.1.1.51
4658:Biology
4612:Ligases
4382:Enzymes
4302:quinone
3886:SULT2A1
3881:SULT1A1
3382:HMG-CoA
3360:enzymes
3352:ketones
3285:4 March
3183:4189905
2810:8171034
2689:8608312
2634:4543405
2559:9205114
2523:9712896
2432:2917704
2380:4511594
2338:17 July
2299:16 July
2247:5166531
2128:9029729
2091:16 July
2030:5417535
1981:5444764
1899:1314080
1828:9029730
1571:fisetin
1551:17β-HSD
1462:Cytosol
1362:11p11.2
1192:12q13.2
1184:HSD17B9
1136:6p21.32
1122:HSD17B8
1067:HSD17B7
1035:12q13.3
1021:HSD17B6
992:Nucleus
988:10p15.1
967:3α-HSD2
888:HSD17B4
850:9q22.32
836:HSD17B3
797:16q23.3
783:HSD17B2
753:Cytosol
749:17q21.2
730:HSD17B1
613:17β-HSD
578:HSD17B9
572:HSD17B8
566:HSD17B7
522:HSD17B6
500:20α-HSD
482:HSD17B5
461:HSD17B4
453:17β-HSD
448:HSD17B3
433:HSD17B2
422:HSD17B1
394:Estriol
381:Estrone
299:estrone
276:steroid
225:17β-HSD
164:QuickGO
129:profile
112:MetaCyc
47:CAS no.
4644:Portal
4586:Lyases
4340:L2HGDH
4326:1.1.99
4236:oxygen
4160:3β-HSD
3309:(MeSH)
3273:
3265:
3226:
3190:
3180:
3141:
3100:
3057:
3049:
3014:
2976:
2968:
2932:
2924:
2889:
2881:
2844:
2817:
2807:
2766:
2731:
2687:
2679:
2641:
2631:
2592:
2557:
2521:
2480:
2439:
2429:
2387:
2377:
2324:
2285:
2254:
2244:
2205:
2162:
2134:
2126:
2077:
2037:
2027:
1988:
1978:
1930:
1905:
1897:
1859:
1834:
1826:
1791:
1752:193845
1750:
1709:
1668:
1627:
1409:4q22.1
1380:vagina
1307:4q22.1
1275:MRXS10
1243:Xp11.2
1081:1q23.3
957:AKR1C3
909:5q23.1
688:Size (
685:Family
606:, and
527:3α-HSD
524:: Has
491:3α-HSD
486:AKR1C3
297:, and
250:which
244:17-KSR
229:HSD17B
192:PubMed
174:Search
160:AmiGO
148:PDBsum
88:ExPASy
76:BRENDA
64:IntEnz
35:EC no.
4538:Types
4298:1.1.5
4270:1.1.4
4232:1.1.3
4199:1.1.2
4165:NSDHL
3968:1.1.1
3714:both:
3454:DMAPP
3271:S2CID
3055:S2CID
2974:S2CID
2930:S2CID
2887:S2CID
2685:S2CID
2478:S2CID
2466:: X.
2132:S2CID
1903:S2CID
1832:S2CID
1523:NADPH
1499:PSDR1
1490:RDH11
1373:NADPH
1101:NADPH
1000:NADPH
861:NADPH
541:from
413:Genes
124:PRIAM
4630:list
4623:EC7
4617:list
4610:EC6
4604:list
4597:EC5
4591:list
4584:EC4
4578:list
4571:EC3
4565:list
4558:EC2
4552:list
4545:EC1
4015:1B10
3976:NADP
3961:1.1)
3833:17β-
3789:17β-
3692:11β-
3582:path
3553:path
3287:2022
3263:PMID
3224:PMID
3188:PMID
3139:PMID
3098:PMID
3047:PMID
3012:PMID
2966:PMID
2922:PMID
2879:PMID
2842:ISBN
2815:PMID
2764:PMID
2729:PMID
2677:PMID
2639:PMID
2590:PMID
2555:PMID
2519:PMID
2437:PMID
2385:PMID
2340:2017
2322:ISBN
2301:2017
2283:ISBN
2252:PMID
2203:PMID
2160:ISBN
2124:PMID
2093:2017
2075:ISBN
2035:PMID
1986:PMID
1928:ISBN
1895:PMID
1857:ISBN
1824:PMID
1789:PMID
1748:PMID
1707:PMID
1666:PMID
1625:PMID
1424:NAD?
1231:MHBD
1176:RDH5
971:PGFS
897:MFP2
658:and
625:and
556:PCOS
497:and
474:and
342:DHEA
301:and
293:and
285:and
283:DHEA
274:and
254:the
204:NCBI
145:PDBe
100:KEGG
4189:17β
4172:11β
4035:7A2
4030:1C4
4025:1C3
4020:1C1
4010:1B1
4005:1A1
3972:NAD
3835:HSD
3818:To
3791:HSD
3783:HSD
3781:3β-
3761:To
3751:To
3719:HSD
3717:3β-
3694:HSD
3654:To
3635:To
3602:To
3521:To
3511:To
3452:To
3433:To
3380:To
3255:doi
3251:301
3216:doi
3178:PMC
3170:doi
3129:doi
3125:277
3039:doi
3035:121
3004:doi
2958:doi
2954:125
2914:doi
2910:218
2871:doi
2867:301
2805:PMC
2795:doi
2756:doi
2752:489
2719:doi
2715:143
2669:doi
2665:343
2629:PMC
2621:doi
2582:doi
2547:doi
2509:doi
2505:273
2468:doi
2427:PMC
2419:doi
2375:PMC
2367:doi
2242:PMC
2234:doi
2193:doi
2116:doi
2025:PMC
2017:doi
1976:PMC
1968:doi
1887:doi
1816:doi
1779:doi
1775:205
1738:doi
1734:252
1697:doi
1693:218
1656:doi
1652:232
1617:doi
1613:336
1573:).
1509:318
1505:SDR
1468:NAD
1456:270
1452:SDR
1406:300
1402:SDR
1359:312
1355:SDR
1327:NAD
1304:300
1300:SDR
1254:NAD
1240:261
1236:SDR
1189:318
1152:NAD
1133:261
1129:SDR
1078:341
1074:SDR
1046:NAD
1032:317
1028:SDR
985:323
977:AKR
939:DBP
925:NAD
914:PXS
906:736
902:SDR
893:DBP
847:310
843:SDR
813:NAD
794:387
790:SDR
746:328
738:SDR
270:in
266:of
258:of
231:) (
180:PMC
136:PDB
4670::
4300::
4272::
4234::
4201::
4155:3β
3970::
3959:EC
3953::
3858::
3350:–
3346::
3277:.
3269:.
3261:.
3249:.
3245:.
3222:.
3212:83
3210:.
3186:.
3176:.
3166:23
3164:.
3160:.
3137:.
3123:.
3119:.
3094:61
3092:.
3053:.
3045:.
3033:.
3010:.
2998:.
2986:^
2972:.
2964:.
2952:.
2928:.
2920:.
2908:.
2885:.
2877:.
2865:.
2813:.
2803:.
2791:20
2789:.
2785:.
2762:.
2750:.
2727:.
2713:.
2709:.
2697:^
2683:.
2675:.
2663:.
2651:^
2637:.
2627:.
2617:56
2615:.
2611:.
2588:.
2578:24
2576:.
2553:.
2543:42
2541:.
2517:.
2503:.
2499:.
2476:.
2464:10
2462:.
2458:.
2435:.
2425:.
2415:87
2413:.
2409:.
2397:^
2383:.
2373:.
2363:28
2361:.
2357:.
2330:.
2291:.
2267:^
2258:.
2250:.
2240:.
2228:.
2224:.
2201:.
2189:29
2187:.
2183:.
2144:^
2130:.
2122:.
2112:62
2110:.
2083:.
2047:^
2033:.
2023:.
2013:24
2011:.
2007:.
1984:.
1974:.
1962:.
1958:.
1942:^
1901:.
1893:.
1883:41
1881:.
1830:.
1822:.
1812:62
1810:.
1787:.
1773:.
1769:.
1746:.
1732:.
1728:.
1705:.
1691:.
1687:.
1664:.
1650:.
1646:.
1623:.
1562:.
1555:.
1516:ER
1485:15
1441:14
1436:?
1417:EP
1415:,
1413:ER
1391:13
1386:?
1366:ER
1344:12
1339:?
1316:EP
1313:,
1311:ER
1289:11
1281:,
1272:,
1247:MC
1222:10
1196:ER
1141:MC
1094:ER
1092:,
1086:PM
1058:?
969:,
943:,
895:,
854:ER
802:ER
691:AA
662:.
602:,
392:↔
383:↔
374:/
370:/
366:↔
357:↔
348:↔
334:↔
305:.
289:,
233:EC
227:,
162:/
4646::
4632:)
4628:(
4619:)
4615:(
4606:)
4602:(
4593:)
4589:(
4580:)
4576:(
4567:)
4563:(
4554:)
4550:(
4374:e
4367:t
4360:v
4152::
3974:/
3957:(
3943:e
3936:t
3929:v
3807:2
3802:1
3730:2
3725:1
3705:2
3700:1
3684::
3680:/
3667::
3362:/
3354:/
3336:e
3329:t
3322:v
3289:.
3257::
3230:.
3218::
3194:.
3172::
3145:.
3131::
3104:.
3076:.
3061:.
3041::
3018:.
3006::
3000:7
2980:.
2960::
2936:.
2916::
2893:.
2873::
2850:.
2821:.
2797::
2770:.
2758::
2735:.
2721::
2691:.
2671::
2645:.
2623::
2596:.
2584::
2561:.
2549::
2525:.
2511::
2484:.
2470::
2443:.
2421::
2391:.
2369::
2342:.
2303:.
2236::
2230:7
2209:.
2195::
2168:.
2138:.
2118::
2095:.
2041:.
2019::
1992:.
1970::
1964:8
1936:.
1909:.
1889::
1865:.
1838:.
1818::
1795:.
1781::
1754:.
1740::
1713:.
1699::
1672:.
1658::
1631:.
1619::
1532:?
1421:?
1212:?
1171:9
1118:8
1063:7
1017:6
952:5
884:4
832:3
779:2
726:1
697:)
676:#
588:.
562:.
518:.
444:.
242:(
223:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.