1738:, in particular 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency. Overall, CYP17A1 is an important target for inhibition in the treatment of prostate cancer because it produces androgen that is required for tumor cell growth. The decreased enzyme activity of CYP17A1 is related to infertility due to hypogonadotropic hypogonadism. In females, folliculogenesis is arrested, while in males, testicular atrophy with interstitial cell proliferation and arrested spermatogenesis. Although generally anovulatory, there are some case reports of women with 17α-hydroxylase deficiency who underwent spontaneous menarche with cyclic menses.
545:
3336:
and in nonhuman primates VT464 was able to suppress circulating testosterone as effectively as abiraterone, but with minimally depressed cortisol (remaining at 82% control compared to only 9% with aberaterone), and without associated increases in pregnenolone, progesterone and mineralocorticoids otherwise observed with abiraterone. Like
Galaterone, VT464 is also in use in clinical trials without co-administration of prednisone. Together with the clear lack of suppression of circulating cortisol in nonhuman primates, these data argue that VT464 may indeed be a selective 17,20 lyase inhibitor.
522:
1928:
444:
419:
1914:
1886:
796:
551:
450:
1849:
1947:
1900:
1872:
3335:
VT464 is another recently developed compound proposed to act as a selective lyase inhibitor, and more complete data is available in the public domain to support this claim. A review of preliminary data released suggest the IC50 for Human CYP17 lyase activity is ten times lower than for hydroxylase 15
1772:
Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous CYP17A1 substrates. Abiraterone is structurally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and interference can
1752:
A multi-locus genetic risk score study based on a combination of 27 loci, including the CYP17A1 gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a
72:
P450c17, CYP17A1, steroid 17-alpha-hydroxylase/17,20 lyase, CYPXVII, cytochrome P450 17A1, cytochrome p450 XVIIA1, cytochrome P450-C17, cytochrome P450, family 17, subfamily A, polypeptide 1, steroid 17-alpha-monooxygenase, cytochrome P450c17, 4.1.2.30, 17-alpha-hydroxyprogesterone aldolase,
260:
2959:
Kostin VA, Zolottsev VA, Kuzikov AV, Masamrekh RA, Shumyantseva VV, Veselovsky AV, et al. (November 2016). "Oxazolinyl derivatives of -21-norpregnene differing in the structure of A and B rings. Facile synthesis and inhibition of CYP17A1 catalytic activity".
2812:
Ma YN, Cao CY, Wang QW, Gui WJ, Zhu GN (October 2016). "Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio)".
1777:
scaffolds is expected to enable the design of compounds that interact more selectively with CYP17A1. Potent inhibitors of the CYP17A1 enzyme provide a last line defense against ectopic androgenesis in advanced prostate cancer.
5868:
1753:
community cohort study (the Malmo Diet and Cancer study) and four additional randomized controlled trials of primary prevention cohorts (JUPITER and ASCOT) and secondary prevention cohorts (CARE and PROVE IT-TIMI 22).
558:
457:
5564:
3461:"Mutation of cytochrome P-45017 alpha gene (CYP17) in a Japanese patient previously reported as having glucocorticoid-responsive hyperaldosteronism: with a review of Japanese patients with mutations of CYP17"
5737:
1835:
which is aimed to avoid co-administration of glucocortoid therapy. In the 2010s it underwent various phases of clinical studies and preclinical models as a drug against prostate cancer or breast cancer.
5773:
3399:"A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer"
5842:
5805:
5864:
5637:
3655:
3568:
Haider SM, Patel JS, Poojari CS, Neidle S (July 2010). "Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy".
1821:
that is now little used. However, ketoconazole competitively inhibits CYP17A1, therefore its effectiveness will depend on the concentration of ketoconazole. This is in contrast to the
1742:
1735:
1724:
1734:
In humans, the CYP17A1 gene is largely associated with endocrine effects and steroid hormone metabolism. Furthermore, mutations in the CYP17A1 gene are associated with rare forms of
2791:
3165:"Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency"
234:
188:
3648:
4900:
3641:
2453:
Storbeck KH, Swart P, Africander D, Conradie R, Louw R, Swart AC (April 2011). "16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction".
1789:, blocks the biosynthesis of androgens by inhibiting the CYP17A1 enzyme. Abiraterone acetate binds in the active site of the enzyme and coordinates the
1054:
366:
1035:
1699:. Cytochrome b5 acts as a facilitator for 17,20 lyase activity of CYP17A1 and can donate a second electron to some P450s. In humans the production of
5365:
2886:
2213:"Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials"
4809:
2045:
207:
2027:
4949:
3633:
1537:
metabolism, though it orients the steroid ligands toward the F and G helices, perpendicular to the heme group, rather than the β1 sheet.
3615:
1254:
5121:
2640:"Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome"
4025:
4020:
3350:"Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment"
5103:
5099:
4439:
4262:
1965:
1261:
5727:
4788:
4308:
3851:
3281:
200:
1680:. Mutations in this gene are associated with isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency,
5620:
3797:
2787:
1375:
tissues. It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces
5795:
5534:
5372:
5081:
4605:
4215:
3965:
167:
5892:
6258:
6248:
3621:
1711:. Phosphorylation of the protein increases 17,20-lyase activity, while dephosphorylation virtually eliminates this activity.
2107:
2010:
5468:
5025:
4941:
3734:
1808:
1786:
257:
5512:
5695:
5266:
4965:
3792:
3116:"Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer"
1989:
4153:
4109:
4012:
3282:"Tokai Pharmaceuticals' Reformulated Galeterone Demonstrates Robust PSA Reductions in Advanced Prostate Cancer Patients"
4101:
4037:
544:
5969:
5668:
5005:
2140:
4240:
1664:
such as cortisol, but both the hydroxylase and 17,20-lyase activities of CYP17A1 are required for the production of
5344:
2699:"Backdoor pathway for dihydrotestosterone biosynthesis: implications for normal and abnormal human sex development"
2268:
2078:
521:
73:
cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), steroid 17 alpha-hydroxylase/17,20 lyase, IPR033282
17:
3523:
Strauss JF (November 2003). "Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome".
161:
5707:
5653:
5142:
4983:
4862:
4561:
3909:
3739:
2014:
1993:
1728:
1708:
1529:, CYP17A1 possesses the canonical cytochrome P450 fold present in other complex P450 enzymes that participate in
5328:
5135:
3890:
1720:
1685:
1099:
148:
143:
6125:
5039:
5009:
4969:
4957:
4255:
4225:
3813:
443:
418:
3932:
3880:
1080:
5193:
5107:
5095:
3663:
1927:
346:
212:
2850:"Endocrine effects of lifelong exposure to low-dose depleted uranium on testicular functions in adult rat"
2849:
557:
456:
136:
5936:
5785:
5245:
4945:
4613:
4220:
3774:
1913:
1885:
2261:"CYP17A1 - Steroid 17-alpha-hydroxylase/17,20 lyase - Homo sapiens (Human) - CYP17A1 gene & protein"
550:
449:
5527:
5128:
5067:
5063:
5051:
5047:
5043:
1505:
protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508
3008:"Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors"
1919:
1891:
1673:
1517:
prosthetic group to catalyze biosynthetic reactions. Based on its known structures while bound to two
1419:
1415:
6226:
6213:
6200:
6187:
6174:
6161:
6148:
6110:
5931:
5882:
5854:
5822:
5431:
5316:
5085:
3885:
2071:"CYP17A1 cytochrome P450 family 17 subfamily A member 1 [Homo sapiens (human)] - Gene - NCBI"
1801:
1692:
868:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
164:
62:
3604:
333:
88:
6253:
6120:
6074:
6017:
5555:
5500:
5238:
5185:
5180:
5035:
4886:
4283:
4248:
3787:
3608:
1654:
1647:
1427:
1408:
390:
354:
45:
3494:
Miller WL, Geller DH, Auchus RJ (1999). "The molecular basis of isolated 17,20 lyase deficiency".
6022:
5777:
5568:
5287:
5160:
3397:
Peer CJ, Schmidt KT, Kindrick JD, Eisner JR, Brown VV, Baskin-Bey E, et al. (October 2019).
3006:
Bonomo S, Hansen CH, Petrunak EM, Scott EE, Styrishave B, Jørgensen FS, et al. (July 2016).
1704:
1646:
and other lipids and are involved in drug metabolism. CYP17A1 has both 17α-hydroxylase activity (
1490:
2291:"Cytochrome P450 17A1 Interactions with the FMN Domain of Its Reductase as Characterized by NMR"
1237:
1216:
1190:
1169:
5916:
5832:
5581:
5114:
5059:
5055:
5021:
4953:
4535:
3856:
3163:
Fernández-Cancio M, Camats N, Flück CE, Zalewski A, Dick B, Frey BM, et al. (April 2018).
1677:
2596:"Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17"
396:
6043:
5962:
5712:
5685:
5520:
5351:
4857:
3818:
2211:
Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, et al. (June 2015).
1855:, showing, at left side, both reactions of 17α-hydroxylase, and both actions of 17, 20 lyase.
1681:
1635:
1407:(-OH) group at carbon 17 position (C17) of the steroid D ring (the 17α-hydroxylase activity,
1352:
432:
374:
124:
2848:
Legendre A, Elie C, Ramambason C, Manens L, Souidi M, Froment P, et al. (August 2016).
1703:
via pregnenolone to17-OHPreg and DHEA by the CYP17A1 requires POR. Human CYP17A1 protein is
6115:
5827:
5790:
5551:
5542:
5309:
5206:
5077:
4976:
4617:
3990:
3871:
3532:
3237:
3019:
2860:
2651:
2509:
2353:
1960:
100:
50:
8:
6079:
5813:
5461:
5167:
4995:
3861:
3627:
3459:
Miura K, Yasuda K, Yanase T, Yamakita N, Sasano H, Nawata H, et al. (October 1996).
1822:
1782:
1506:
57:
3536:
3348:
Madan RA, Schmidt KT, Karzai F, Peer CJ, Cordes LM, Chau CH, et al. (August 2020).
3241:
3023:
2864:
2655:
2513:
2357:
6012:
5576:
4961:
4176:
3692:
3684:
3556:
3436:
3423:
3398:
3374:
3349:
3321:
3296:
3258:
3226:"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001"
3225:
3191:
3164:
3140:
3115:
3091:
3064:
3040:
3007:
2985:
2936:
2911:
2769:
2728:
2530:
2498:"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001"
2497:
2478:
2425:
2398:
2374:
2342:"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001"
2341:
2317:
2290:
2237:
2212:
2185:
2160:
1598:. In addition to classical steroidogenic tissue, CYP17A1 has also been detected in the
378:
5722:
4062:
2228:
1825:, that permanently (rather than competitively) disables CYP17A1, once it binds to it.
969:
964:
959:
954:
949:
944:
939:
934:
918:
913:
908:
903:
898:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
5610:
4270:
4187:
4117:
3782:
3763:
3585:
3548:
3511:
3482:
3440:
3428:
3379:
3326:
3263:
3214:
3196:
3145:
3096:
3045:
2989:
2977:
2941:
2878:
2830:
2773:
2720:
2679:
2674:
2639:
2617:
2576:
2535:
2470:
2430:
2379:
2322:
2242:
2190:
2136:
1832:
1818:
1767:
1380:
326:
250:
155:
3560:
2732:
1899:
1871:
6058:
6053:
6027:
5955:
4195:
3715:
3668:
3577:
3540:
3503:
3472:
3418:
3410:
3369:
3361:
3316:
3308:
3253:
3245:
3186:
3176:
3135:
3127:
3086:
3076:
3035:
3027:
2973:
2969:
2931:
2923:
2868:
2822:
2759:
2710:
2669:
2659:
2607:
2566:
2525:
2517:
2482:
2462:
2420:
2410:
2369:
2361:
2312:
2302:
2232:
2224:
2180:
2172:
1595:
1564:
1560:
1552:
1364:
1360:
1356:
637:
568:
512:
467:
2826:
358:
6105:
6089:
6002:
5700:
5410:
4279:
3947:
2555:"Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis"
2099:
1852:
1696:
1631:
1545:
1530:
1482:, including the remarkable carbon-carbon bond scission catalyzed by this enzyme.
1463:
612:
382:
3312:
2176:
2050:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2032:
National Center for
Biotechnology Information, U.S. National Library of Medicine
6143:
6084:
5926:
5906:
5901:
5543:
4718:
4057:
3976:
3755:
3477:
3460:
3414:
3365:
3065:"Disorders of Sex Development: Classification, Review, and Impact on Fertility"
2644:
Proceedings of the
National Academy of Sciences of the United States of America
2571:
2554:
1952:
1804:
1661:
1607:
1591:
1568:
1466:
superfamily of enzymes. The cytochrome P450 proteins are generally regarded as
1384:
1368:
713:
183:
3581:
3507:
3297:"The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature"
2927:
2873:
2466:
795:
6242:
6048:
6007:
5493:
5397:
5358:
5280:
5273:
5259:
5219:
5200:
5174:
2912:"Structural insights into the function of steroidogenic cytochrome P450 17A1"
2788:"Entrez Gene: CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1"
2664:
1660:). The 17α-hydroxylase activity of CYP17A1 is required for the generation of
1588:
1549:
1467:
1355:. It is ubiquitously expressed in many tissues and cell types, including the
1341:
824:
337:, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1
3544:
2764:
2747:
2415:
2307:
773:
651:
5997:
5745:
5741:
5016:
4990:
4894:
4880:
4873:
4779:
4759:
4752:
4735:
4677:
4660:
4653:
4646:
4639:
4632:
4600:
4593:
3957:
3589:
3552:
3432:
3383:
3330:
3267:
3200:
3149:
3131:
3100:
3049:
2981:
2945:
2882:
2834:
2724:
2621:
2612:
2595:
2580:
2539:
2474:
2434:
2383:
2326:
2246:
2194:
1905:
1877:
1814:
1774:
1700:
1669:
1400:
1396:
630:
409:
3515:
3486:
2683:
1657:
1650:
1470:
that catalyze many reactions involved in drug metabolism and synthesis of
1430:
1411:
1301:
1296:
112:
6221:
6156:
5992:
4586:
4542:
4073:
3985:
3900:
3833:
3744:
3726:
3676:
2260:
2070:
1828:
1639:
1580:
1572:
1534:
1522:
1510:
1471:
1144:
1125:
3249:
2521:
2399:"Structures of human steroidogenic cytochrome P450 17A1 with substrates"
2365:
1638:. Proteins in this family are monooxygenases that catalyze synthesis of
5877:
4271:
3843:
3664:
3181:
3081:
2715:
2698:
1797:
1526:
529:
426:
362:
3218:
3031:
303:
299:
295:
291:
287:
283:
279:
6195:
6169:
5846:
5809:
5753:
5547:
5486:
4687:
4275:
4181:
4148:
4002:
3924:
1518:
1459:
1376:
999:
596:
583:
495:
482:
370:
5625:
5443:
5403:
5390:
5335:
5302:
5252:
5230:
5225:
5211:
4140:
4083:
3998:
3710:
3162:
1946:
1665:
1576:
1556:
1404:
1392:
1388:
1285:
2553:
Udhane SS, Dick B, Hu Q, Hartmann RW, Pandey AV (September 2016).
1848:
4912:
4839:
4829:
4819:
4802:
4792:
4784:
4772:
4768:
4764:
4745:
4697:
4625:
4621:
4609:
4500:
4495:
4490:
4465:
4460:
4444:
4364:
4359:
4339:
4206:
4201:
3937:
3702:
3680:
1691:
Furthermore, the 17,20-lyase activity is dependent on cytochrome
1643:
1489:
gene may also contain variants associated with increased risk of
1475:
1450:
gene resides on chromosome 10 at the band 10q24.3 and contains 8
1111:
1066:
984:
980:
131:
1743:
Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency
350:
6208:
5978:
5763:
5758:
5717:
4579:
4575:
4565:
4551:
4547:
4515:
4510:
4505:
4485:
4480:
4475:
4470:
4434:
4429:
4424:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4354:
4349:
4344:
4334:
4329:
4313:
4303:
4298:
4127:
4122:
4050:
4045:
3672:
2958:
2452:
2397:
Petrunak EM, DeVore NM, Porubsky PR, Scott EE (November 2014).
1619:
1615:
1603:
1337:
1269:
1021:
804:
195:
107:
95:
83:
6182:
5910:
5645:
5603:
5596:
5591:
5586:
4866:
4728:
4415:
1793:
iron through its pyridine nitrogen, mimicking the substrate.
1611:
1599:
1584:
1479:
1423:
1372:
2910:
Yadav R, Petrunak EM, Estrada DF, Scott EE (February 2017).
2847:
5690:
5678:
5673:
5663:
5658:
5641:
5615:
4920:
2396:
1790:
1514:
1455:
1451:
1422:
to split the side-chain off the steroid nucleus (the 17,20-
1348:
119:
5947:
2638:
Zhang LH, Rodriguez H, Ohno S, Miller WL (November 1995).
3458:
3396:
3301:
The
Journal of Steroid Biochemistry and Molecular Biology
3284:(Press release). Tokai Pharmaceuticals. January 29, 2014.
3005:
2909:
2165:
The
Journal of Steroid Biochemistry and Molecular Biology
1719:
Mutations in this gene are associated with rare forms of
1502:
3567:
2696:
2637:
2210:
620:
233:
3347:
3114:
Bordeau BM, Ciulla DA, Callahan BP (September 2016).
3113:
2697:
Fukami M, Homma K, Hasegawa T, Ogata T (April 2013).
2133:
Medical physiology: a cellular and molecular approach
785:
4155:
4111:
4103:
4039:
4014:
3465:
The
Journal of Clinical Endocrinology and Metabolism
2552:
2288:
2130:
1942:
1548:
of CYP17A1 has been found in all of the traditional
2559:
2289:Estrada DF, Laurence JS, Scott EE (February 2016).
2126:
2124:
3493:
2135:. St. Louis, Mo: Elsevier Saunders. p. 1180.
2006:
2004:
2002:
1985:
1983:
1981:
2158:
1773:pose a liability in terms of side effects. Using
1725:17α-hydroxylase deficiency/17,20-lyase deficiency
567:
466:
6240:
2121:
2448:
2446:
2444:
1999:
1978:
3001:
2999:
2161:"CYP17 inhibitors for prostate cancer therapy"
2011:GRCm38: Ensembl release 89: ENSMUSG00000003555
883:17-alpha-hydroxyprogesterone aldolase activity
5963:
5528:
4256:
3649:
2745:
2633:
2631:
3390:
3341:
3288:
3207:
3056:
2811:
2593:
2441:
2206:
2204:
3223:
2996:
2495:
2339:
2159:Vasaitis TS, Bruno RD, Njar VC (May 2011).
1990:GRCh38: Ensembl release 89: ENSG00000148795
1614:, CYP17A1 has been reported in the kidney,
5970:
5956:
5535:
5521:
4263:
4249:
3656:
3642:
3525:Annals of the New York Academy of Sciences
3294:
3062:
2628:
1395:. More specifically, the enzyme acts upon
3607:at the U.S. National Library of Medicine
3476:
3422:
3373:
3320:
3274:
3257:
3190:
3180:
3139:
3090:
3080:
3039:
2935:
2872:
2763:
2714:
2673:
2663:
2611:
2570:
2529:
2424:
2414:
2373:
2316:
2306:
2236:
2201:
2184:
1966:Cytochrome P450 oxidoreductase deficiency
3852:Farnesyl-diphosphate farnesyltransferase
1847:
1714:
1634:superfamily of enzymes localized in the
35:Steroid 17-alpha-hydroxylase/17,20 lyase
3798:Isopentenyl-diphosphate delta isomerase
3522:
853:steroid 17-alpha-monooxygenase activity
27:Mammalian protein found in Homo sapiens
14:
6241:
4216:Steroidogenic acute regulatory protein
1707:on serine and threonine residues by a
1344:type that in humans is encoded by the
5951:
5516:
4244:
3637:
1761:
1509:. As an enzyme, CYP17A1 possesses an
572:
533:
528:
471:
430:
425:
5728:24-hydroxycholesterol 7α-hydroxylase
3403:Cancer Chemotherapy and Pharmacology
3224:DeVore NM, Scott EE (January 2012).
2916:Molecular and Cellular Endocrinology
2496:DeVore NM, Scott EE (January 2012).
2455:Molecular and Cellular Endocrinology
2340:DeVore NM, Scott EE (January 2012).
2154:
2152:
2065:
2063:
2061:
2059:
1863:
1809:castration-resistant prostate cancer
1787:castration-resistant prostate cancer
1462:. This gene encodes a member of the
1458:of this gene spans a length of 1527
3793:Pyrophosphomevalonate decarboxylase
3711:Acetyl-Coenzyme A acetyltransferase
3295:Bird IM, Abbott DH (October 2016).
2600:The Journal of Biological Chemistry
2594:Pandey AV, Miller WL (April 2005).
2403:The Journal of Biological Chemistry
2295:The Journal of Biological Chemistry
1756:
945:glucocorticoid biosynthetic process
24:
3451:
3063:Acién P, Acién M (November 2020).
2739:
2100:"BioGPS - your Gene Portal System"
1839:
1747:
25:
6270:
3598:
2149:
2056:
397:1.14.14.32 1.14.14.19, 1.14.14.32
1945:
1926:
1912:
1898:
1884:
1870:
794:
556:
549:
543:
520:
455:
448:
442:
417:
232:
5708:Cholesterol 7 alpha-hydroxylase
5654:Flavin-containing monooxygenase
3966:Cholesterol side-chain cleavage
3910:24-Dehydrocholesterol reductase
3740:3-hydroxybutyrate dehydrogenase
3156:
3107:
2952:
2903:
2892:from the original on 2024-02-02
2841:
2805:
2794:from the original on 2010-03-07
2780:
2748:"Alternative androgen pathways"
2690:
2587:
2546:
2489:
2390:
2333:
2282:
2271:from the original on 2016-10-12
2253:
2131:Boulpaep EL, Boron, WF (2005).
2110:from the original on 2011-08-20
2081:from the original on 2015-06-23
1729:isolated 17,20-lyase deficiency
1695:(POR) cytochrome b5 (CYB5) and
3891:7-Dehydrocholesterol reductase
2974:10.1016/j.steroids.2016.06.002
2092:
2038:
2020:
1736:congenital adrenal hyperplasia
1721:congenital adrenal hyperplasia
935:progesterone metabolic process
899:endoplasmic reticulum membrane
805:More reference expression data
774:More reference expression data
13:
1:
4226:Reverse cholesterol transport
3814:Dimethylallyltranstransferase
3354:Clinical Genitourinary Cancer
2827:10.1016/j.aquatox.2016.08.006
2229:10.1016/S0140-6736(14)61730-X
1971:
1709:cAMP-dependent protein kinase
1678:dehydroepiandrosterone (DHEA)
1540:
940:androgen biosynthetic process
541:
440:
6259:Steroid hormone biosynthesis
6249:Genes on human chromosome 10
3570:Journal of Molecular Biology
3069:Journal of Clinical Medicine
2746:Masiutin M, Yadav M (2023).
1653:) and 17,20-lyase activity (
1436:
960:steroid biosynthetic process
955:hormone biosynthetic process
7:
5977:
5937:Deoxyhypusine monooxygenase
4221:Cholesterol total synthesis
3313:10.1016/j.jsbmb.2016.04.021
2177:10.1016/j.jsbmb.2010.11.005
1938:
1672:sex steroids by converting
1630:CYP17A1 is a member of the
1625:
10:
6275:
3933:Cholesterol 7α-hydroxylase
3881:Lanosterol 14α-demethylase
3626:gene details page in the
3478:10.1210/jcem.81.10.8855840
3415:10.1007/s00280-019-03908-0
3366:10.1016/j.clgc.2019.11.002
2572:10.1016/j.bbrc.2016.07.019
1765:
1740:
1496:
1255:Chr 10: 102.83 – 102.84 Mb
698:left lobe of thyroid gland
6134:
6126:Michaelis–Menten kinetics
6098:
6067:
6036:
5985:
5932:Ecdysone 20-monooxygenase
5891:
5883:Stearoyl-CoA desaturase-1
5863:
5855:Dopamine beta-hydroxylase
5841:
5823:Phenylalanine hydroxylase
5804:
5772:
5736:
5636:
5563:
5478:
5453:
5382:
5152:
4930:
4849:
4707:
4524:
4453:
4413:
4322:
4291:
4169:
4138:
4081:
4071:
3974:
3955:
3946:
3922:
3899:
3886:Sterol-C5-desaturase-like
3870:
3841:
3831:
3806:
3772:
3753:
3725:
3700:
3691:
3582:10.1016/j.jmb.2010.05.069
3508:10.3109/07435809809032692
2928:10.1016/j.mce.2016.08.035
2874:10.1016/j.tox.2016.08.014
2467:10.1016/j.mce.2010.11.016
2046:"Mouse PubMed Reference:"
2028:"Human PubMed Reference:"
1785:, which is used to treat
1587:, and, more recently, in
1318:steroid 17α-monooxygenase
1300:
1295:
1291:
1284:
1268:
1249:
1234:
1230:
1213:
1209:
1202:
1187:
1183:
1166:
1162:
1155:
1142:
1138:
1123:
1119:
1110:
1097:
1093:
1078:
1074:
1065:
1052:
1048:
1033:
1029:
1020:
1005:
998:
994:
978:
965:steroid metabolic process
823:
819:
802:
793:
784:
771:
720:
711:
658:
649:
619:
611:
607:
590:
577:
540:
519:
510:
506:
489:
476:
439:
416:
407:
403:
394:
389:
344:
341:
331:
324:
319:
276:
271:
254:
249:
244:
240:
231:
226:
206:
194:
182:
177:
173:
154:
142:
130:
118:
106:
94:
82:
77:
68:
56:
44:
39:
34:
6018:Diffusion-limited enzyme
3788:Phosphomevalonate kinase
3609:Medical Subject Headings
2665:10.1073/pnas.92.23.10619
1262:Chr 19: 46.66 – 46.66 Mb
950:sterol metabolic process
752:epithelium of epididymis
3545:10.1196/annals.1290.005
2752:WikiJournal of Medicine
2416:10.1074/jbc.M114.610998
2308:10.1074/jbc.M115.677294
1920:17α-Hydroxyprogesterone
1892:17α-Hydroxypregnenolone
1674:17α-hydroxypregnenolone
1513:that associates with a
1491:coronary artery disease
1441:
1420:17α-hydroxypregnenolone
1416:17α-hydroxyprogesterone
878:oxidoreductase activity
5917:Squalene monooxygenase
5833:Tryptophan hydroxylase
5582:HIF prolyl-hydroxylase
3857:Squalene monooxygenase
3605:CYP17A1+protein,+human
3132:10.1002/cmdc.201600238
2703:Developmental Dynamics
2613:10.1074/jbc.M414673200
1856:
858:monooxygenase activity
574:19 C3|19 38.97 cM
6111:Eadie–Hofstee diagram
6044:Allosteric regulation
5713:Methane monooxygenase
5686:Nitric oxide synthase
3938:Sterol 27-hydroxylase
3819:Geranyl pyrophosphate
2765:10.15347/WJM/2023.003
1851:
1715:Clinical significance
1682:pseudohermaphroditism
1636:endoplasmic reticulum
919:endoplasmic reticulum
694:right coronary artery
535:Chromosome 19 (mouse)
433:Chromosome 10 (human)
6121:Lineweaver–Burk plot
5828:Tyrosine hydroxylase
5552:steroid hydroxylases
3872:7-Dehydrocholesterol
3620:genome location and
2075:www.ncbi.nlm.nih.gov
1961:Steroidogenic enzyme
1831:(VT-464) is a novel
1326:17-alpha-hydroxylase
1314:Cytochrome P450 17A1
666:right adrenal cortex
272:List of PDB id codes
245:Available structures
5778:iron–sulfur protein
3862:Lanosterol synthase
3628:UCSC Genome Browser
3537:2003NYASA.997...42S
3250:10.1038/nature10743
3242:2012Natur.482..116D
3024:2016NatSR...629468B
2865:2016Toxgy.368...58L
2656:1995PNAS...9210619Z
2650:(23): 10619–10623.
2606:(14): 13265–13271.
2522:10.1038/nature10743
2514:2012Natur.482..116D
2409:(47): 32952–32964.
2366:10.1038/nature10743
2358:2012Natur.482..116D
2223:(9984): 2264–2271.
1823:abiraterone acetate
1783:abiraterone acetate
1693:P450 oxidoreductase
1686:adrenal hyperplasia
1507:amino acid residues
970:sex differentiation
736:seminiferous tubule
686:right lobe of liver
670:left adrenal cortex
662:right adrenal gland
383:CYP17A1 - orthologs
6080:Enzyme superfamily
6013:Enzyme promiscuity
5577:Prolyl hydroxylase
4177:Steroid metabolism
3693:Mevalonate pathway
3685:steroid metabolism
3496:Endocrine Research
3182:10.3390/ph11020037
3082:10.3390/jcm9113555
3012:Scientific Reports
2859:. 368–369: 58–68.
2815:Aquatic Toxicology
2716:10.1002/dvdy.23892
1857:
1762:CYP17A1 inhibitors
1501:CYP17A1 is a 57.4
1381:mineralocorticoids
1100:ENSMUSG00000003555
928:Biological process
914:neuronal cell body
892:Cellular component
831:Molecular function
682:right uterine tube
6236:
6235:
5945:
5944:
5611:Lysyl hydroxylase
5510:
5509:
4238:
4237:
4234:
4233:
4188:Steroid sulfatase
4165:
4164:
3918:
3917:
3827:
3826:
3783:Mevalonate kinase
3764:HMG-CoA reductase
3471:(10): 3797–3801.
3360:(4): 258–267.e1.
3236:(7383): 116–119.
3126:(18): 1983–1986.
3032:10.1038/srep29468
2508:(7383): 116–119.
2352:(7383): 116–119.
1933:Steroid numbering
1864:Additional images
1861:
1860:
1833:CYP17A1 inhibitor
1819:CYP17A1 inhibitor
1768:CYP17A1 inhibitor
1596:ovarian follicles
1311:
1310:
1307:
1306:
1280:
1279:
1245:
1244:
1224:
1223:
1198:
1197:
1177:
1176:
1151:
1150:
1132:
1131:
1106:
1105:
1087:
1086:
1061:
1060:
1042:
1041:
990:
989:
848:metal ion binding
815:
814:
811:
810:
780:
779:
767:
766:
705:
704:
603:
602:
502:
501:
315:
314:
311:
310:
255:Ortholog search:
222:
221:
218:
217:
137:metabolic pathway
16:(Redirected from
6266:
6116:Hanes–Woolf plot
6059:Enzyme activator
6054:Enzyme inhibitor
6028:Enzyme catalysis
5972:
5965:
5958:
5949:
5948:
5537:
5530:
5523:
5514:
5513:
4282:(Most belong to
4265:
4258:
4251:
4242:
4241:
4196:sulfotransferase
4157:
4113:
4105:
4079:
4078:
4041:
4016:
3953:
3952:
3839:
3838:
3718:(regulated step)
3716:HMG-CoA synthase
3698:
3697:
3669:lipid metabolism
3658:
3651:
3644:
3635:
3634:
3593:
3576:(5): 1078–1098.
3564:
3519:
3502:(3–4): 817–825.
3490:
3480:
3445:
3444:
3426:
3394:
3388:
3387:
3377:
3345:
3339:
3338:
3324:
3292:
3286:
3285:
3278:
3272:
3271:
3261:
3221:
3211:
3205:
3204:
3194:
3184:
3160:
3154:
3153:
3143:
3111:
3105:
3104:
3094:
3084:
3060:
3054:
3053:
3043:
3003:
2994:
2993:
2956:
2950:
2949:
2939:
2907:
2901:
2900:
2898:
2897:
2891:
2876:
2854:
2845:
2839:
2838:
2809:
2803:
2802:
2800:
2799:
2784:
2778:
2777:
2767:
2743:
2737:
2736:
2718:
2694:
2688:
2687:
2677:
2667:
2635:
2626:
2625:
2615:
2591:
2585:
2584:
2574:
2565:(4): 1005–1010.
2550:
2544:
2543:
2533:
2493:
2487:
2486:
2450:
2439:
2438:
2428:
2418:
2394:
2388:
2387:
2377:
2337:
2331:
2330:
2320:
2310:
2301:(8): 3990–4003.
2286:
2280:
2279:
2277:
2276:
2257:
2251:
2250:
2240:
2208:
2199:
2198:
2188:
2156:
2147:
2146:
2128:
2119:
2118:
2116:
2115:
2096:
2090:
2089:
2087:
2086:
2067:
2054:
2053:
2042:
2036:
2035:
2024:
2018:
2008:
1997:
1987:
1955:
1950:
1949:
1930:
1916:
1902:
1888:
1874:
1844:
1843:
1757:As a drug target
1565:zona fasciculata
1561:zona reticularis
1559:, including the
1414:), or acts upon
1365:zona glomerulosa
1361:zona fasciculata
1357:zona reticularis
1293:
1292:
1264:
1257:
1240:
1228:
1227:
1219:
1207:
1206:
1203:RefSeq (protein)
1193:
1181:
1180:
1172:
1160:
1159:
1136:
1135:
1117:
1116:
1091:
1090:
1072:
1071:
1046:
1045:
1027:
1026:
996:
995:
838:iron ion binding
821:
820:
807:
798:
791:
790:
776:
716:
714:Top expressed in
709:
708:
654:
652:Top expressed in
647:
646:
626:
625:
609:
608:
599:
586:
575:
560:
553:
547:
536:
524:
508:
507:
498:
485:
474:
459:
452:
446:
435:
421:
405:
404:
399:
385:
336:
329:
306:
269:
268:
263:
242:
241:
236:
224:
223:
175:
174:
32:
31:
21:
18:17-a hydroxylase
6274:
6273:
6269:
6268:
6267:
6265:
6264:
6263:
6254:Cytochrome P450
6239:
6238:
6237:
6232:
6144:Oxidoreductases
6130:
6106:Enzyme kinetics
6094:
6090:List of enzymes
6063:
6032:
6003:Catalytic triad
5981:
5976:
5946:
5941:
5895:- miscellaneous
5887:
5859:
5837:
5800:
5768:
5732:
5723:14α-demethylase
5632:
5559:
5544:Oxidoreductases
5541:
5511:
5506:
5474:
5449:
5411:Halloween genes
5378:
5148:
4926:
4845:
4703:
4520:
4449:
4409:
4318:
4287:
4280:cytochrome P450
4269:
4239:
4230:
4170:Other/ungrouped
4161:
4134:
4092:17α-Hydroxylase
4067:
4063:11β-Hydroxylase
4008:17α-Hydroxylase
3977:corticosteroids
3970:
3948:Steroidogenesis
3942:
3914:
3895:
3866:
3823:
3802:
3768:
3749:
3721:
3687:
3662:
3601:
3596:
3454:
3452:Further reading
3449:
3448:
3395:
3391:
3346:
3342:
3293:
3289:
3280:
3279:
3275:
3213:
3212:
3208:
3169:Pharmaceuticals
3161:
3157:
3112:
3108:
3061:
3057:
3004:
2997:
2957:
2953:
2908:
2904:
2895:
2893:
2889:
2852:
2846:
2842:
2810:
2806:
2797:
2795:
2786:
2785:
2781:
2744:
2740:
2695:
2691:
2636:
2629:
2592:
2588:
2551:
2547:
2494:
2490:
2461:(1–2): 92–101.
2451:
2442:
2395:
2391:
2338:
2334:
2287:
2283:
2274:
2272:
2265:www.uniprot.org
2259:
2258:
2254:
2209:
2202:
2157:
2150:
2143:
2129:
2122:
2113:
2111:
2098:
2097:
2093:
2084:
2082:
2069:
2068:
2057:
2044:
2043:
2039:
2026:
2025:
2021:
2009:
2000:
1988:
1979:
1974:
1951:
1944:
1941:
1934:
1931:
1922:
1917:
1908:
1903:
1894:
1889:
1880:
1875:
1866:
1853:Steroidogenesis
1842:
1840:Steroidogenesis
1805:clinical trials
1770:
1764:
1759:
1750:
1748:Clinical marker
1745:
1723:, specifically
1717:
1697:phosphorylation
1662:glucocorticoids
1632:cytochrome P450
1628:
1592:granulosa cells
1543:
1531:steroidogenesis
1499:
1464:cytochrome P450
1444:
1439:
1385:glucocorticoids
1334:17,20-desmolase
1322:17α-hydroxylase
1302:View/Edit Mouse
1297:View/Edit Human
1260:
1253:
1250:Location (UCSC)
1236:
1215:
1189:
1168:
1081:ENSG00000148795
974:
923:
887:
803:
772:
763:
758:
754:
750:
748:theca folliculi
746:
742:
738:
734:
730:
726:
712:
701:
696:
692:
688:
684:
680:
676:
672:
668:
664:
650:
594:
581:
573:
563:
562:
561:
554:
534:
511:Gene location (
493:
480:
472:
462:
461:
460:
453:
431:
408:Gene location (
395:
345:
332:
325:
278:
256:
28:
23:
22:
15:
12:
11:
5:
6272:
6262:
6261:
6256:
6251:
6234:
6233:
6231:
6230:
6217:
6204:
6191:
6178:
6165:
6152:
6138:
6136:
6132:
6131:
6129:
6128:
6123:
6118:
6113:
6108:
6102:
6100:
6096:
6095:
6093:
6092:
6087:
6082:
6077:
6071:
6069:
6068:Classification
6065:
6064:
6062:
6061:
6056:
6051:
6046:
6040:
6038:
6034:
6033:
6031:
6030:
6025:
6020:
6015:
6010:
6005:
6000:
5995:
5989:
5987:
5983:
5982:
5975:
5974:
5967:
5960:
5952:
5943:
5942:
5940:
5939:
5934:
5929:
5924:
5919:
5914:
5907:Heme oxygenase
5904:
5902:Cyclooxygenase
5898:
5896:
5889:
5888:
5886:
5885:
5880:
5874:
5872:
5861:
5860:
5858:
5857:
5851:
5849:
5839:
5838:
5836:
5835:
5830:
5825:
5819:
5817:
5802:
5801:
5799:
5798:
5793:
5788:
5782:
5780:
5770:
5769:
5767:
5766:
5761:
5756:
5750:
5748:
5734:
5733:
5731:
5730:
5725:
5720:
5715:
5710:
5705:
5704:
5703:
5698:
5693:
5683:
5682:
5681:
5676:
5671:
5666:
5661:
5650:
5648:
5634:
5633:
5631:
5630:
5629:
5628:
5623:
5613:
5608:
5607:
5606:
5601:
5600:
5599:
5594:
5589:
5573:
5571:
5569:2-oxoglutarate
5561:
5560:
5540:
5539:
5532:
5525:
5517:
5508:
5507:
5505:
5504:
5497:
5490:
5482:
5480:
5476:
5475:
5473:
5472:
5465:
5457:
5455:
5451:
5450:
5448:
5447:
5440:
5408:
5407:
5406:
5394:
5386:
5384:
5380:
5379:
5377:
5376:
5369:
5362:
5355:
5348:
5341:
5340:
5339:
5332:
5320:
5313:
5306:
5299:
5298:
5297:
5294:
5284:
5277:
5270:
5263:
5256:
5249:
5242:
5235:
5234:
5233:
5228:
5216:
5215:
5214:
5209:
5197:
5190:
5189:
5188:
5183:
5171:
5164:
5156:
5154:
5150:
5149:
5147:
5146:
5139:
5132:
5125:
5118:
5111:
5089:
5071:
5029:
5013:
4999:
4987:
4980:
4973:
4934:
4932:
4928:
4927:
4925:
4924:
4917:
4916:
4915:
4905:
4904:
4903:
4891:
4890:
4889:
4877:
4870:
4853:
4851:
4847:
4846:
4844:
4843:
4833:
4823:
4813:
4806:
4796:
4776:
4756:
4749:
4739:
4732:
4722:
4711:
4709:
4705:
4704:
4702:
4701:
4691:
4681:
4674:
4664:
4657:
4650:
4643:
4636:
4629:
4597:
4590:
4583:
4569:
4555:
4539:
4528:
4526:
4522:
4521:
4519:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4457:
4455:
4451:
4450:
4448:
4447:
4442:
4437:
4432:
4427:
4421:
4419:
4411:
4410:
4408:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4326:
4324:
4320:
4319:
4317:
4316:
4311:
4306:
4301:
4295:
4293:
4289:
4288:
4268:
4267:
4260:
4253:
4245:
4236:
4235:
4232:
4231:
4229:
4228:
4223:
4218:
4212:
4211:
4210:
4209:
4204:
4192:
4191:
4190:
4173:
4171:
4167:
4166:
4163:
4162:
4160:
4159:
4151:
4145:
4143:
4136:
4135:
4133:
4132:
4131:
4130:
4125:
4115:
4107:
4099:
4094:
4088:
4086:
4076:
4069:
4068:
4066:
4065:
4060:
4058:21-Hydroxylase
4055:
4054:
4053:
4048:
4031:
4030:
4029:
4028:
4023:
4010:
3994:
3993:
3991:18-Hydroxylase
3981:
3979:
3972:
3971:
3969:
3968:
3962:
3960:
3950:
3944:
3943:
3941:
3940:
3935:
3929:
3927:
3920:
3919:
3916:
3915:
3913:
3912:
3906:
3904:
3897:
3896:
3894:
3893:
3888:
3883:
3877:
3875:
3868:
3867:
3865:
3864:
3859:
3854:
3848:
3846:
3836:
3829:
3828:
3825:
3824:
3822:
3821:
3816:
3810:
3808:
3804:
3803:
3801:
3800:
3795:
3790:
3785:
3779:
3777:
3770:
3769:
3767:
3766:
3760:
3758:
3756:Mevalonic acid
3751:
3750:
3748:
3747:
3742:
3737:
3731:
3729:
3723:
3722:
3720:
3719:
3713:
3707:
3705:
3695:
3689:
3688:
3661:
3660:
3653:
3646:
3638:
3632:
3631:
3612:
3600:
3599:External links
3597:
3595:
3594:
3565:
3520:
3491:
3455:
3453:
3450:
3447:
3446:
3409:(4): 759–770.
3389:
3340:
3287:
3273:
3206:
3155:
3106:
3055:
2995:
2951:
2902:
2840:
2804:
2779:
2738:
2709:(4): 320–329.
2689:
2627:
2586:
2545:
2488:
2440:
2389:
2332:
2281:
2252:
2200:
2171:(1–2): 23–31.
2148:
2141:
2120:
2091:
2055:
2037:
2019:
1998:
1976:
1975:
1973:
1970:
1969:
1968:
1963:
1957:
1956:
1953:Biology portal
1940:
1937:
1936:
1935:
1932:
1925:
1923:
1918:
1911:
1909:
1904:
1897:
1895:
1890:
1883:
1881:
1876:
1869:
1865:
1862:
1859:
1858:
1841:
1838:
1766:Main article:
1763:
1760:
1758:
1755:
1749:
1746:
1716:
1713:
1705:phosphorylated
1627:
1624:
1608:adipose tissue
1569:adrenal cortex
1542:
1539:
1498:
1495:
1468:monooxygenases
1443:
1440:
1438:
1435:
1369:adrenal cortex
1309:
1308:
1305:
1304:
1299:
1289:
1288:
1282:
1281:
1278:
1277:
1275:
1273:
1266:
1265:
1258:
1251:
1247:
1246:
1243:
1242:
1232:
1231:
1225:
1222:
1221:
1211:
1210:
1204:
1200:
1199:
1196:
1195:
1185:
1184:
1178:
1175:
1174:
1164:
1163:
1157:
1153:
1152:
1149:
1148:
1140:
1139:
1133:
1130:
1129:
1121:
1120:
1114:
1108:
1107:
1104:
1103:
1095:
1094:
1088:
1085:
1084:
1076:
1075:
1069:
1063:
1062:
1059:
1058:
1050:
1049:
1043:
1040:
1039:
1031:
1030:
1024:
1018:
1017:
1012:
1007:
1003:
1002:
992:
991:
988:
987:
976:
975:
973:
972:
967:
962:
957:
952:
947:
942:
937:
931:
929:
925:
924:
922:
921:
916:
911:
906:
901:
895:
893:
889:
888:
886:
885:
880:
875:
873:lyase activity
870:
865:
860:
855:
850:
845:
843:oxygen binding
840:
834:
832:
828:
827:
817:
816:
813:
812:
809:
808:
800:
799:
788:
782:
781:
778:
777:
769:
768:
765:
764:
762:
761:
757:
753:
749:
745:
741:
740:adrenal cortex
737:
733:
729:
725:
721:
718:
717:
706:
703:
702:
700:
699:
695:
691:
687:
683:
679:
675:
671:
667:
663:
659:
656:
655:
643:
642:
634:
623:
617:
616:
613:RNA expression
605:
604:
601:
600:
592:
588:
587:
579:
576:
571:
565:
564:
555:
548:
542:
538:
537:
532:
526:
525:
517:
516:
504:
503:
500:
499:
491:
487:
486:
478:
475:
470:
464:
463:
454:
447:
441:
437:
436:
429:
423:
422:
414:
413:
401:
400:
393:
387:
386:
343:
339:
338:
330:
322:
321:
317:
316:
313:
312:
309:
308:
274:
273:
265:
264:
253:
247:
246:
238:
237:
229:
228:
220:
219:
216:
215:
210:
204:
203:
198:
192:
191:
186:
180:
179:
171:
170:
159:
152:
151:
146:
140:
139:
134:
128:
127:
122:
116:
115:
110:
104:
103:
98:
92:
91:
86:
80:
79:
75:
74:
70:
66:
65:
60:
54:
53:
48:
42:
41:
37:
36:
26:
9:
6:
4:
3:
2:
6271:
6260:
6257:
6255:
6252:
6250:
6247:
6246:
6244:
6228:
6224:
6223:
6218:
6215:
6211:
6210:
6205:
6202:
6198:
6197:
6192:
6189:
6185:
6184:
6179:
6176:
6172:
6171:
6166:
6163:
6159:
6158:
6153:
6150:
6146:
6145:
6140:
6139:
6137:
6133:
6127:
6124:
6122:
6119:
6117:
6114:
6112:
6109:
6107:
6104:
6103:
6101:
6097:
6091:
6088:
6086:
6085:Enzyme family
6083:
6081:
6078:
6076:
6073:
6072:
6070:
6066:
6060:
6057:
6055:
6052:
6050:
6049:Cooperativity
6047:
6045:
6042:
6041:
6039:
6035:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6008:Oxyanion hole
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5990:
5988:
5984:
5980:
5973:
5968:
5966:
5961:
5959:
5954:
5953:
5950:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5918:
5915:
5912:
5908:
5905:
5903:
5900:
5899:
5897:
5894:
5890:
5884:
5881:
5879:
5876:
5875:
5873:
5870:
5866:
5862:
5856:
5853:
5852:
5850:
5848:
5844:
5840:
5834:
5831:
5829:
5826:
5824:
5821:
5820:
5818:
5815:
5814:BH4 dependent
5811:
5807:
5803:
5797:
5794:
5792:
5789:
5787:
5784:
5783:
5781:
5779:
5775:
5771:
5765:
5762:
5760:
5757:
5755:
5752:
5751:
5749:
5747:
5743:
5739:
5735:
5729:
5726:
5724:
5721:
5719:
5716:
5714:
5711:
5709:
5706:
5702:
5699:
5697:
5694:
5692:
5689:
5688:
5687:
5684:
5680:
5677:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5656:
5655:
5652:
5651:
5649:
5647:
5643:
5639:
5635:
5627:
5624:
5622:
5619:
5618:
5617:
5614:
5612:
5609:
5605:
5602:
5598:
5595:
5593:
5590:
5588:
5585:
5584:
5583:
5580:
5579:
5578:
5575:
5574:
5572:
5570:
5566:
5562:
5557:
5553:
5549:
5545:
5538:
5533:
5531:
5526:
5524:
5519:
5518:
5515:
5503:
5502:
5498:
5496:
5495:
5491:
5489:
5488:
5484:
5483:
5481:
5477:
5471:
5470:
5466:
5464:
5463:
5459:
5458:
5456:
5452:
5446:
5445:
5441:
5438:
5434:
5433:
5428:
5424:
5420:
5416:
5412:
5409:
5405:
5402:
5401:
5400:
5399:
5395:
5393:
5392:
5388:
5387:
5385:
5381:
5375:
5374:
5370:
5368:
5367:
5363:
5361:
5360:
5356:
5354:
5353:
5349:
5347:
5346:
5342:
5338:
5337:
5333:
5331:
5330:
5326:
5325:
5324:
5321:
5319:
5318:
5314:
5312:
5311:
5307:
5305:
5304:
5300:
5295:
5292:
5291:
5290:
5289:
5285:
5283:
5282:
5278:
5276:
5275:
5271:
5269:
5268:
5264:
5262:
5261:
5257:
5255:
5254:
5250:
5248:
5247:
5243:
5241:
5240:
5236:
5232:
5229:
5227:
5224:
5223:
5222:
5221:
5217:
5213:
5210:
5208:
5205:
5204:
5203:
5202:
5198:
5196:
5195:
5191:
5187:
5184:
5182:
5179:
5178:
5177:
5176:
5172:
5170:
5169:
5165:
5163:
5162:
5158:
5157:
5155:
5151:
5145:
5144:
5140:
5138:
5137:
5133:
5131:
5130:
5126:
5124:
5123:
5119:
5117:
5116:
5112:
5109:
5105:
5101:
5097:
5093:
5090:
5087:
5083:
5079:
5075:
5072:
5069:
5065:
5061:
5057:
5053:
5049:
5045:
5041:
5037:
5033:
5030:
5027:
5023:
5019:
5018:
5014:
5011:
5007:
5003:
5000:
4997:
4993:
4992:
4988:
4986:
4985:
4981:
4979:
4978:
4974:
4971:
4967:
4963:
4959:
4955:
4951:
4947:
4943:
4939:
4936:
4935:
4933:
4929:
4923:
4922:
4918:
4914:
4911:
4910:
4909:
4906:
4902:
4899:
4898:
4897:
4896:
4892:
4888:
4885:
4884:
4883:
4882:
4878:
4876:
4875:
4871:
4868:
4864:
4860:
4859:
4855:
4854:
4852:
4848:
4841:
4837:
4834:
4831:
4827:
4824:
4821:
4817:
4814:
4812:
4811:
4807:
4804:
4800:
4797:
4794:
4790:
4786:
4782:
4781:
4777:
4774:
4770:
4766:
4762:
4761:
4757:
4755:
4754:
4750:
4747:
4743:
4740:
4738:
4737:
4733:
4730:
4726:
4723:
4720:
4716:
4713:
4712:
4710:
4706:
4699:
4695:
4692:
4689:
4685:
4682:
4680:
4679:
4675:
4672:
4668:
4665:
4663:
4662:
4658:
4656:
4655:
4651:
4649:
4648:
4644:
4642:
4641:
4637:
4635:
4634:
4630:
4627:
4623:
4619:
4615:
4611:
4607:
4603:
4602:
4598:
4596:
4595:
4591:
4589:
4588:
4584:
4581:
4577:
4573:
4570:
4567:
4563:
4559:
4556:
4553:
4549:
4545:
4544:
4540:
4537:
4533:
4530:
4529:
4527:
4523:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4458:
4456:
4452:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4422:
4420:
4417:
4412:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4327:
4325:
4321:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4296:
4294:
4290:
4285:
4281:
4277:
4273:
4266:
4261:
4259:
4254:
4252:
4247:
4246:
4243:
4227:
4224:
4222:
4219:
4217:
4214:
4213:
4208:
4205:
4203:
4200:
4199:
4198:
4197:
4193:
4189:
4186:
4185:
4184:
4183:
4178:
4175:
4174:
4172:
4168:
4158:
4152:
4150:
4147:
4146:
4144:
4142:
4137:
4129:
4126:
4124:
4121:
4120:
4119:
4116:
4114:
4108:
4106:
4100:
4098:
4095:
4093:
4090:
4089:
4087:
4085:
4080:
4077:
4075:
4070:
4064:
4061:
4059:
4056:
4052:
4049:
4047:
4044:
4043:
4042:
4036:
4033:
4032:
4027:
4024:
4022:
4019:
4018:
4017:
4011:
4009:
4006:
4004:
4000:
3996:
3995:
3992:
3989:
3987:
3983:
3982:
3980:
3978:
3973:
3967:
3964:
3963:
3961:
3959:
3954:
3951:
3949:
3945:
3939:
3936:
3934:
3931:
3930:
3928:
3926:
3921:
3911:
3908:
3907:
3905:
3902:
3898:
3892:
3889:
3887:
3884:
3882:
3879:
3878:
3876:
3873:
3869:
3863:
3860:
3858:
3855:
3853:
3850:
3849:
3847:
3845:
3840:
3837:
3835:
3830:
3820:
3817:
3815:
3812:
3811:
3809:
3805:
3799:
3796:
3794:
3791:
3789:
3786:
3784:
3781:
3780:
3778:
3776:
3771:
3765:
3762:
3761:
3759:
3757:
3752:
3746:
3743:
3741:
3738:
3736:
3735:HMG-CoA lyase
3733:
3732:
3730:
3728:
3724:
3717:
3714:
3712:
3709:
3708:
3706:
3704:
3699:
3696:
3694:
3690:
3686:
3682:
3678:
3674:
3670:
3666:
3659:
3654:
3652:
3647:
3645:
3640:
3639:
3636:
3629:
3625:
3624:
3619:
3618:
3613:
3610:
3606:
3603:
3602:
3591:
3587:
3583:
3579:
3575:
3571:
3566:
3562:
3558:
3554:
3550:
3546:
3542:
3538:
3534:
3530:
3526:
3521:
3517:
3513:
3509:
3505:
3501:
3497:
3492:
3488:
3484:
3479:
3474:
3470:
3466:
3462:
3457:
3456:
3442:
3438:
3434:
3430:
3425:
3420:
3416:
3412:
3408:
3404:
3400:
3393:
3385:
3381:
3376:
3371:
3367:
3363:
3359:
3355:
3351:
3344:
3337:
3332:
3328:
3323:
3318:
3314:
3310:
3306:
3302:
3298:
3291:
3283:
3277:
3269:
3265:
3260:
3255:
3251:
3247:
3243:
3239:
3235:
3231:
3227:
3220:
3216:
3210:
3202:
3198:
3193:
3188:
3183:
3178:
3174:
3170:
3166:
3159:
3151:
3147:
3142:
3137:
3133:
3129:
3125:
3121:
3117:
3110:
3102:
3098:
3093:
3088:
3083:
3078:
3074:
3070:
3066:
3059:
3051:
3047:
3042:
3037:
3033:
3029:
3025:
3021:
3017:
3013:
3009:
3002:
3000:
2991:
2987:
2983:
2979:
2975:
2971:
2967:
2963:
2955:
2947:
2943:
2938:
2933:
2929:
2925:
2921:
2917:
2913:
2906:
2888:
2884:
2880:
2875:
2870:
2866:
2862:
2858:
2851:
2844:
2836:
2832:
2828:
2824:
2820:
2816:
2808:
2793:
2789:
2783:
2775:
2771:
2766:
2761:
2757:
2753:
2749:
2742:
2734:
2730:
2726:
2722:
2717:
2712:
2708:
2704:
2700:
2693:
2685:
2681:
2676:
2671:
2666:
2661:
2657:
2653:
2649:
2645:
2641:
2634:
2632:
2623:
2619:
2614:
2609:
2605:
2601:
2597:
2590:
2582:
2578:
2573:
2568:
2564:
2560:
2556:
2549:
2541:
2537:
2532:
2527:
2523:
2519:
2515:
2511:
2507:
2503:
2499:
2492:
2484:
2480:
2476:
2472:
2468:
2464:
2460:
2456:
2449:
2447:
2445:
2436:
2432:
2427:
2422:
2417:
2412:
2408:
2404:
2400:
2393:
2385:
2381:
2376:
2371:
2367:
2363:
2359:
2355:
2351:
2347:
2343:
2336:
2328:
2324:
2319:
2314:
2309:
2304:
2300:
2296:
2292:
2285:
2270:
2266:
2262:
2256:
2248:
2244:
2239:
2234:
2230:
2226:
2222:
2218:
2214:
2207:
2205:
2196:
2192:
2187:
2182:
2178:
2174:
2170:
2166:
2162:
2155:
2153:
2144:
2142:1-4160-2328-3
2138:
2134:
2127:
2125:
2109:
2105:
2101:
2095:
2080:
2076:
2072:
2066:
2064:
2062:
2060:
2051:
2047:
2041:
2033:
2029:
2023:
2016:
2012:
2007:
2005:
2003:
1995:
1991:
1986:
1984:
1982:
1977:
1967:
1964:
1962:
1959:
1958:
1954:
1948:
1943:
1929:
1924:
1921:
1915:
1910:
1907:
1901:
1896:
1893:
1887:
1882:
1879:
1873:
1868:
1867:
1854:
1850:
1846:
1845:
1837:
1834:
1830:
1826:
1824:
1820:
1816:
1812:
1810:
1806:
1803:
1799:
1794:
1792:
1788:
1784:
1779:
1776:
1769:
1754:
1744:
1739:
1737:
1732:
1730:
1726:
1722:
1712:
1710:
1706:
1702:
1698:
1694:
1689:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1659:
1656:
1652:
1649:
1645:
1641:
1637:
1633:
1623:
1621:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1590:
1586:
1582:
1578:
1574:
1570:
1566:
1562:
1558:
1554:
1551:
1550:steroidogenic
1547:
1538:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1494:
1492:
1488:
1483:
1481:
1477:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1434:
1432:
1429:
1425:
1421:
1417:
1413:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1354:
1353:chromosome 10
1350:
1347:
1343:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1303:
1298:
1294:
1290:
1287:
1283:
1276:
1274:
1271:
1267:
1263:
1259:
1256:
1252:
1248:
1241:
1239:
1233:
1229:
1226:
1220:
1218:
1212:
1208:
1205:
1201:
1194:
1192:
1186:
1182:
1179:
1173:
1171:
1165:
1161:
1158:
1156:RefSeq (mRNA)
1154:
1147:
1146:
1141:
1137:
1134:
1128:
1127:
1122:
1118:
1115:
1113:
1109:
1102:
1101:
1096:
1092:
1089:
1083:
1082:
1077:
1073:
1070:
1068:
1064:
1057:
1056:
1051:
1047:
1044:
1038:
1037:
1032:
1028:
1025:
1023:
1019:
1016:
1013:
1011:
1008:
1004:
1001:
997:
993:
986:
982:
977:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
932:
930:
927:
926:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
896:
894:
891:
890:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
835:
833:
830:
829:
826:
825:Gene ontology
822:
818:
806:
801:
797:
792:
789:
787:
783:
775:
770:
759:
755:
751:
747:
743:
739:
735:
731:
727:
724:Gonadal ridge
723:
722:
719:
715:
710:
707:
697:
693:
689:
685:
681:
677:
673:
669:
665:
661:
660:
657:
653:
648:
645:
644:
641:
639:
635:
633:
632:
628:
627:
624:
622:
618:
614:
610:
606:
598:
593:
589:
585:
580:
570:
566:
559:
552:
546:
539:
531:
527:
523:
518:
514:
509:
505:
497:
492:
488:
484:
479:
469:
465:
458:
451:
445:
438:
434:
428:
424:
420:
415:
411:
406:
402:
398:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
340:
335:
328:
323:
318:
307:
305:
301:
297:
293:
289:
285:
281:
275:
270:
267:
266:
262:
259:
252:
248:
243:
239:
235:
230:
225:
214:
211:
209:
205:
202:
199:
197:
193:
190:
187:
185:
181:
176:
172:
169:
166:
163:
160:
157:
153:
150:
147:
145:
141:
138:
135:
133:
129:
126:
123:
121:
117:
114:
113:NiceZyme view
111:
109:
105:
102:
99:
97:
93:
90:
87:
85:
81:
76:
71:
67:
64:
61:
59:
55:
52:
49:
47:
43:
38:
33:
30:
19:
6222:Translocases
6219:
6206:
6193:
6180:
6167:
6157:Transferases
6154:
6141:
5998:Binding site
5921:
5746:flavoprotein
5550:, including
5548:dioxygenases
5499:
5492:
5485:
5467:
5460:
5442:
5436:
5430:
5426:
5422:
5418:
5414:
5396:
5389:
5371:
5364:
5357:
5350:
5343:
5334:
5327:
5322:
5315:
5308:
5301:
5286:
5279:
5272:
5265:
5258:
5251:
5244:
5237:
5218:
5199:
5192:
5173:
5166:
5159:
5141:
5134:
5127:
5120:
5113:
5091:
5073:
5031:
5015:
5001:
4989:
4982:
4975:
4937:
4919:
4907:
4893:
4879:
4872:
4856:
4835:
4825:
4815:
4808:
4798:
4778:
4758:
4751:
4741:
4734:
4724:
4714:
4693:
4683:
4676:
4670:
4666:
4659:
4652:
4645:
4638:
4631:
4599:
4592:
4585:
4571:
4557:
4541:
4531:
4194:
4180:
4118:5α-Reductase
4096:
4091:
4074:sex hormones
4034:
4007:
3997:
3984:
3958:pregnenolone
3622:
3616:
3573:
3569:
3531:(1): 42–48.
3528:
3524:
3499:
3495:
3468:
3464:
3406:
3402:
3392:
3357:
3353:
3343:
3334:
3304:
3300:
3290:
3276:
3233:
3229:
3209:
3172:
3168:
3158:
3123:
3119:
3109:
3075:(11): 3555.
3072:
3068:
3058:
3015:
3011:
2965:
2961:
2954:
2919:
2915:
2905:
2894:. Retrieved
2856:
2843:
2818:
2814:
2807:
2796:. Retrieved
2782:
2755:
2751:
2741:
2706:
2702:
2692:
2647:
2643:
2603:
2599:
2589:
2562:
2558:
2548:
2505:
2501:
2491:
2458:
2454:
2406:
2402:
2392:
2349:
2345:
2335:
2298:
2294:
2284:
2273:. Retrieved
2264:
2255:
2220:
2216:
2168:
2164:
2132:
2112:. Retrieved
2103:
2094:
2083:. Retrieved
2074:
2049:
2040:
2031:
2022:
1906:Progesterone
1878:Pregnenolone
1827:
1817:is an older
1815:Ketoconazole
1813:
1800:has been in
1796:Since 2014,
1795:
1780:
1775:nonsteroidal
1771:
1751:
1733:
1718:
1701:testosterone
1690:
1629:
1581:thecal cells
1573:Leydig cells
1544:
1521:inhibitors,
1500:
1486:
1484:
1478:, and other
1447:
1445:
1401:progesterone
1397:pregnenolone
1345:
1333:
1329:
1325:
1321:
1317:
1313:
1312:
1235:
1214:
1188:
1167:
1143:
1124:
1098:
1079:
1053:
1034:
1014:
1009:
863:heme binding
732:spermatocyte
678:right testis
674:human kidney
636:
629:
494:102,837,472
481:102,830,531
342:External IDs
277:
101:BRENDA entry
29:
5993:Active site
4272:Cytochromes
4097:17,20-Lyase
3986:aldosterone
3901:Desmosterol
3834:cholesterol
3745:Thiophorase
3727:Ketogenesis
3677:cholesterol
3307:: 136–146.
3120:ChemMedChem
2968:: 114–122.
1829:Seviteronel
1670:oestrogenic
1640:cholesterol
1555:except the
1535:cholesterol
1523:abiraterone
1511:active site
1472:cholesterol
1371:as well as
1342:hydroxylase
1330:17,20-lyase
728:Leydig cell
690:left testis
595:46,661,611
582:46,655,604
320:Identifiers
89:IntEnz view
40:Identifiers
6243:Categories
6196:Isomerases
6170:Hydrolases
6037:Regulation
5878:Tyrosinase
5845:: reduced
5808:: reduced
5776:: reduced
5740:: reduced
5479:CYP701-999
5454:CYP501-699
5383:CYP301-499
5153:CYP101-281
4276:oxygenases
3925:Bile acids
3844:lanosterol
3679:synthesis
3665:Metabolism
2896:2024-02-02
2857:Toxicology
2798:2017-08-30
2275:2016-10-11
2114:2016-10-11
2104:biogps.org
2085:2016-09-27
2017:, May 2017
1996:, May 2017
1972:References
1798:galeterone
1741:See also:
1666:androgenic
1658:1.14.14.32
1651:1.14.14.19
1589:luteinized
1546:Expression
1541:Expression
1527:galeterone
1431:1.14.14.32
1426:activity,
1412:1.14.14.19
1377:progestins
640:(ortholog)
363:HomoloGene
158:structures
125:KEGG entry
69:Alt. names
63:9029-67-8
51:1.14.14.19
6075:EC number
5847:ascorbate
5810:pteridine
5487:CYP704B22
4182:sulfatase
4149:Aromatase
4141:estrogens
4084:androgens
4003:cortisone
3441:199056344
3222:;
3175:(2): 37.
3018:: 29468.
2990:205256638
2922:: 68–75.
2821:: 55–64.
2774:257943362
1802:phase III
1781:The drug
1610:. In the
1519:steroidal
1437:Structure
1403:to add a
1393:estrogens
1389:androgens
1367:) of the
1363:(but not
1238:NP_031835
1217:NP_000093
1191:NM_007809
1170:NM_000102
1000:Orthologs
391:EC number
371:GeneCards
78:Databases
6099:Kinetics
6023:Cofactor
5986:Activity
5501:CYP720A1
5469:CYP504B1
5444:CYP318A1
5437:CYP315A1
5432:CYP314A1
5427:CYP307A2
5423:CYP307A1
5419:CYP306A1
5415:CYP302A1
5391:CYP303A1
5366:CYP199A2
5345:CYP176A1
5303:CYP154C3
5267:CYP125A1
5253:CYP119A1
5246:CYP113A1
5194:CYP106A2
5168:CYP102A1
5161:CYP101A1
4931:CYP71-99
4850:CYP51-69
4708:CYP21-49
3999:cortisol
3807:Geranyl-
3590:20595043
3561:23559461
3553:14644808
3433:31367790
3384:32327394
3331:27154414
3268:22266943
3201:29710837
3150:27435344
3101:33158283
3050:27406023
2982:27505042
2962:Steroids
2946:27566228
2887:Archived
2883:27544493
2835:27571716
2792:Archived
2733:44702659
2725:23073980
2622:15687493
2581:27395338
2540:22266943
2475:21095220
2435:25301938
2384:22266943
2327:26719338
2269:Archived
2247:25748612
2195:21092758
2108:Archived
2079:Archived
2013:–
1992:–
1939:See also
1644:steroids
1626:Function
1557:placenta
1476:steroids
1405:hydroxyl
1336:) is an
1286:Wikidata
979:Sources:
904:membrane
744:placenta
473:10q24.32
213:proteins
201:articles
189:articles
162:RCSB PDB
6209:Ligases
5979:Enzymes
5893:1.14.99
5871:: other
5865:1.14.18
5843:1.14.17
5806:1.14.16
5774:1.14.15
5738:1.14.14
5638:1.14.13
5565:1.14.11
5373:CYP255A
5352:CYP183A
5317:CYP161C
5310:CYP158A
5143:CYP99A3
5136:CYP97C1
5129:CYP93E1
5122:CYP90C1
5115:CYP88D6
4984:CYP73A1
4977:CYP72A1
4525:CYP5-20
4207:SULT2A1
4202:SULT1A1
3703:HMG-CoA
3681:enzymes
3673:ketones
3623:CYP17A1
3617:CYP17A1
3533:Bibcode
3516:9888582
3487:8855840
3424:8132106
3375:7415516
3322:5046225
3259:3271139
3238:Bibcode
3192:6027421
3141:5588864
3092:7694247
3041:4942611
3020:Bibcode
2937:5235955
2861:Bibcode
2684:7479852
2652:Bibcode
2531:3271139
2510:Bibcode
2483:5503049
2426:4239641
2375:3271139
2354:Bibcode
2318:4759177
2238:4608367
2186:3047603
2015:Ensembl
1994:Ensembl
1585:ovaries
1583:of the
1575:of the
1567:of the
1553:tissues
1497:Protein
1487:CYP17A1
1448:CYP17A1
1373:gonadal
1346:CYP17A1
1340:of the
1112:UniProt
1067:Ensembl
1006:Species
985:QuickGO
760:decidua
615:pattern
375:CYP17A1
334:CYP17A1
327:Aliases
227:CYP17A1
149:profile
132:MetaCyc
58:CAS no.
6183:Lyases
5742:flavin
5621:ALKBH1
5494:CYP710
5462:CYP503
5398:CYP305
5359:CYP197
5323:CYP170
5288:CYP152
5281:CYP147
5274:CYP139
5260:CYP123
5239:CYP111
5220:CYP109
5201:CYP107
5175:CYP105
4414:CYP3 (
3614:Human
3611:(MeSH)
3588:
3559:
3551:
3514:
3485:
3439:
3431:
3421:
3382:
3372:
3329:
3319:
3266:
3256:
3230:Nature
3199:
3189:
3148:
3138:
3099:
3089:
3048:
3038:
2988:
2980:
2944:
2934:
2881:
2833:
2772:
2731:
2723:
2682:
2672:
2620:
2579:
2538:
2528:
2502:Nature
2481:
2473:
2433:
2423:
2382:
2372:
2346:Nature
2325:
2315:
2245:
2235:
2217:Lancet
2193:
2183:
2139:
1684:, and
1620:spleen
1618:, and
1616:thymus
1606:, and
1604:kidney
1579:, the
1577:testes
1571:, the
1480:lipids
1454:. The
1391:, and
1338:enzyme
1272:search
1270:PubMed
1145:P27786
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351:609300
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5646:NADPH
5604:P4HTM
5597:EGLN3
5592:EGLN2
5587:EGLN1
5558:1.14)
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5032:CYP79
5017:CYP76
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4938:CYP71
4921:CYP61
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4667:CYP17
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4633:CYP12
4601:CYP11
4594:CYP10
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4286:1.14)
4035:both:
3775:DMAPP
3557:S2CID
3437:S2CID
2986:S2CID
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2853:(PDF)
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2675:40663
2479:S2CID
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1600:heart
1452:exons
1424:lyase
1055:13074
1015:Mouse
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513:Mouse
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5669:FMO3
5664:FMO2
5659:FMO1
5642:NADH
5616:AlkB
4587:CYP9
4572:CYP8
4558:CYP7
4543:CYP6
4532:CYP5
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3512:PMID
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621:Bgee
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427:Chr.
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300:4NKY
296:4NKX
292:4NKW
288:4NKV
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280:3RUK
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4962:AJ4
4501:F22
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4491:F11
4466:A22
4461:A11
4445:A43
4440:A37
4365:C19
4360:C18
4340:A13
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3411:doi
3370:PMC
3362:doi
3317:PMC
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3254:PMC
3246:doi
3234:482
3215:PDB
3187:PMC
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3136:PMC
3128:doi
3087:PMC
3077:doi
3036:PMC
3028:doi
2970:doi
2966:115
2932:PMC
2924:doi
2920:441
2869:doi
2823:doi
2819:179
2760:doi
2711:doi
2707:242
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2313:PMC
2303:doi
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2233:PMC
2225:doi
2221:385
2181:PMC
2173:doi
2169:125
1676:to
1594:in
1533:or
1503:kDa
1433:).
1351:on
756:lip
591:End
490:End
379:OMA
355:MGI
251:PDB
184:PMC
156:PDB
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5869:19
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5556:EC
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5435:,
5429:,
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5421:,
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5336:B1
5329:A1
5296:B1
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5231:E1
5226:B1
5212:G1
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5186:D7
5181:A1
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5102:,
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5080:,
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5066:,
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5062:,
5060:D2
5058:,
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5054:,
5052:B3
5050:,
5048:B2
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5044:B1
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5040:A2
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5036:A1
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5006:A1
4996:D1
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4960:,
4958:Z6
4956:,
4954:C4
4952:,
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4887:A1
4867:F1
4865:,
4863:A1
4840:A1
4830:A1
4820:B1
4803:A1
4793:C1
4791:,
4789:B1
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4785:A1
4773:C1
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4769:B1
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4746:A1
4729:A1
4719:A2
4698:A1
4688:A1
4671:A1
4626:C1
4624:,
4622:B3
4620:,
4618:B2
4616:,
4614:B1
4612:,
4610:A2
4608:,
4606:A1
4580:B1
4578:,
4576:A1
4566:B1
4564:,
4562:A1
4552:M2
4550:,
4548:G1
4536:A1
4516:Z1
4511:X1
4506:V2
4486:F8
4481:F3
4476:F2
4471:B1
4435:A7
4430:A5
4425:A4
4405:W1
4400:U1
4395:S1
4390:R1
4385:J2
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4375:E1
4370:D6
4355:C9
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4345:B6
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