5-HT2C receptor - Knowledge

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to produce the functional, full-length 5-HT2CR protein. Unedited pre-mRNAs tend to be spliced at the GU1 site, resulting in the truncated, non-functional protein if translated 76,77. However, most pre-mRNAs edited at more than one position are spliced at GU2 77. Thus, when editing is inefficient, increased splicing at GU1 may act as a control mechanism to decrease biosynthesis of the 5-HT2CR-INI and thereby limit serotonin response. Third, RNA editing controls the ultimate physiological output of constitutively active receptors by affecting the cell surface expression of the 5-HT2CR. The 5-HT2CR-VGV, which displays the lowest level of constitutive activity, is fully expressed at the cell surface under basal conditions and is rapidly internalized in the presence of agonist 78; additionally, in vitro, LSD shows negligible activity with this isoform. In contrast, the 5-HT2CR-INI is constitutively internalized and accumulates in endosomes 78.

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ADARs for editing. Disruption of this inverted repeat was demonstrated to cease all editing. The different 5HT2CR mRNA isoforms are expressed differently throughout the brain, yet not all of the 24 have been detected perhaps due to tissue specific expression or low frequency editing of a particular type. Those isoforms that are not expressed at all or at a very low frequency are linked by being edited only at site C' and/or site B but not at site A. Some examples of differences in frequency of editing and site edited in different parts of the human brain of 5HT2CR include low frequency of editing in cerebellum and nearly all editing is at site D while in the hippocampus editing frequency is higher with site A being the main editing site. Site C' is only found edited in the thalamus. The most common isoform in human brain is the VSV isoform.

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at A and B sites was also increased because of this. C' and D sites require ADAR2 and editing is decreased by the presence of ADAR1 with editing of C' site only observed in ADAR1 double knock out mice. The C site has been shown to be mainly edited by ADAR2 but in presence of upregulated expression of ADAR1, there was an increase in editing of this site and the enzymes presence can also result in limited editing in ADAR 2 knock out mice. This demonstrates that there must be some form interaction between the two A to I editing enzymes. Also such interactions and tissue specific expression of ADARs interaction may explain the variety in editing patterns in different regions of the brain.

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isoform, INI. 72–76. Most evidence for the effect of editing on function comes from downstream measurements of receptor activity, radio ligand binding and functional studies. Inhibitory effects are linked to the extent of editing. Those isoforms with a higher level of editing require higher levels of serotonin to activate the phospholipase c pathway. Unedited INI form has a greater tendency to isomerise to an active form which can more easily interact with G proteins. This indicates that RNA editing here may be a mechanism for regulating neuronal excitability by stabilising receptor signalling.

155: 132: 1593:. As the human gene is located in the X chromosome, males have only one copy of the gene whereas women have two, meaning that mutations in the gene affect the phenotype of men even when the allele would be recessive in nature. As women have two copies of the gene, but only one allele is expressed in each cell, they are a mosaic for polymorphisms, meaning that one genetic variant may be prevalent in one tissue and another variant will be prevalent in a different tissue (as with all other x-linked genetic variations). 406: 413: 161: 2345:

with a wide variability in results especially those relating to schizophrenia. Some studies have noted that there is an increase in RNA editing at site A in depressed suicide victims. E site editing was observed to be increased in individuals with major depression. In rat models this increase is also observed and can be reversed with fluoxetine with some suggestion that E site editing maybe linked to major depression.

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site splicing results in translation of the full length receptor while editing at GU1 is known to result in translation of a truncated protein. This is thought to be a regulatory mechanism to decrease the amount of unedited isoform INI to limit serotonin response when editing is inefficient. Most of the pre-mRNAs which are edited are spliced at the GU2 site.

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Serotonin family of receptors are often linked to pathology of several human mental conditions such as Schizophrenia, anxiety, Bipolar disorder and major depression. There have been several experimental investigations into the effects of alternative editing patterns of the 5HT2CR and these conditions

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Editing is also thought to influence splicing. Three different spliced isoforms of the receptor exist. Editing regulates the amount of 5HT2CR mRNA which leads to translation of the full length protein selection of alternative splice sites. t76,77. These splice sites are termed Gu1, Gu2, GU3. Only GU2

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These codon changes which can occur due to A to I editing at these sites can lead to a maximum of 32 different mRNA variants leading to 24 different protein isoforms. The number of protein isoforms is less than 32 since some amino acids are encoded by more than one codon. Another editing site, site F

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Second, the editing pattern controls the amount of the 5-HT2CR mRNA that leads to the expression of full-length protein through the modulation of alternative splice site selection 76,77. Among three alternative splice donor sites (GU1 to GU3; Fig. 4C), GU2 is the only site that forms the mature mRNA

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Editing results in reduced affinity for specific G proteins which in turn affects internal signalling via second messengers (Phospholipase C signalling system). The fully edited isoform, VGV, considerably reduces 5-HT potency, G-protein coupling and agonist binding, compared to the unedited protein

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Mice knock out and other studies have been used to determine which ADAR enzyme are involved in editing. Editing at A and B sites has been demonstrated to be due to ADAR1 editing. Also since ADAR1 expression is increased in response to the presence of interferon α, it was also observed that editing

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is thought to have a regulatory role in the brain. ADAR1 and ADAR2 are widely expressed in tissues while ADAR3 is restricted to the brain. The double stranded regions of RNA are formed by base-pairing between residues in the close to region of the editing site with residues usually in a neighboring

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Editing occurs in 5 different closely located sites within exon 5, which corresponds to the second intracellular loop of the final protein. The sites are known as A, B, C′ (previously called E), C and D, and are predicted to occur within amino acid positions 156, 158 and 160. Several codon changes

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receptor is the only serotonin receptor edited despite its close sequence similarities to other family members. 5HT2CR is different due to possessing an imperfect inverted repeat at the end of exon 5 and the beginning of intron 5 allowing formation of an RNA duplex producing the dsRNA required by

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RNA editing of this receptor occurs at 4 locations in the rat. Editing also occurs in the mouse. The initial demonstration of RNA editing in rat. The predominant isoform in rat brain is VNV which differs from the most common type found in humans. The editing complementary sequence is known to be

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ADARs bind interact directly with the dsRNA substrate via their double stranded RNA binding domains. If an editing site occurs within a coding sequence, it can result in a codon change. This can lead to translation of a protein isoform due to a change in its primary protein structure. Therefore,

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Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, et al. (June 2014). "Multiparameter optimization in CNS drug discovery: design of pyrimidoazepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B

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As mentioned editing results in several codon changes. The editing sites are found in the second intracellular domain of the protein which is also the receptors G protein coupling domain. Therefore, editing of these sites can affect the affinity of the receptor for G protein binding.

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Dekeyne A, Brocco M, Loiseau F, Gobert A, Rivet JM, Di Cara B, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization".

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Editing is also thought to function in cell surface expression of the receptor subtype. The fully edited VGV, which has the lowest level of constitutive activity, is fully expressed at the cell surface while the non-edited INI is internalised and accumulates in endosome.

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Birzniece V, Johansson IM, Wang MD, Bäckström T, Olsson T (February 2002). "Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats".

1569:. Significant correlations are suggested, specifically in relation to psychiatric disorders such as depression, OCD, and anxiety-related conditions. Polymorphisms also correlate with susceptibility to a number of conditions including 1522:

and proopiomelanocortin in the anterior pituitary lobe. In rats, restraint stress (which can produce depressive symptoms if being chronic) induces secretion of prolactin, ACTH, vasopressin and oxytocin which is partially mediated via

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Samochowiec J, Smolka M, Winterer G, Rommelspacher H, Schmidt LG, Sander T (April 1999). "Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability".

1061:, that in humans is located on the X chromosome. As males have one copy of the gene and females have one of the two copies of the gene repressed, polymorphisms at this receptor can affect the two sexes to differing extent. 2185:. It is the only serotonin receptor as well as the only member of the large family of 7 transmembrane receptors (7TMRs) known to be edited. Different levels of editing result in a variety of effects on receptor function. 2501:"Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers" 168: 5122:

Stam NJ, Vanderheyden P, van Alebeek C, Klomp J, de Boer T, van Delft AM, Olijve W (November 1994). "Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor".

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antagonism increases dopamine release in response to reinforcing drugs, and many dopaminergic stimuli. Feeding, social interaction, and sexual activity all release dopamine subject to inhibition of 5-HT

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Yang W, Wang Q, Kanes SJ, Murray JM, Nishikura K (April 2004). "Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy".

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Milatovich A, Hsieh CL, Bonaminio G, Tecott L, Julius D, Francke U (December 1992). "Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4)".

2245:, SINEs ( especially Alu repeats) The function of A to I editing in these regions is thought to involve creation of splice sites and retention of RNAs in the nucleus amongst others. 3484:"Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive-Compulsive Disorder" 2870:"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis" 2603:

Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (December 1995). "Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera".

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Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, et al. (July 1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes".

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Stahl SM, Sommer B, Allers KA (January 2011). "Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder".

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has also been located in the exon complementary sequence (ECS) of intron 5. The ECS required for formation of double stranded RNA structure is found within intron 5.

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gene expression in the brain. This could possibly comprise a link between viral infections and associated depression. Cytokine therapy has been shown to increase 5-HT

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Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D (April 1995). "Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors".

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Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB (May 1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing".

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Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, Emeson RB (May 1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing".

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Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction".

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receptor. Responses during such conditions as dehydration or haemorrhage causes the release of oxytocin via serotonergic response that is partly mediated by 5-HT

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Hackler EA, Airey DC, Shannon CC, Sodhi MS, Sanders-Bush E (May 2006). "5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice".

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Xie E, Zhu L, Zhao L, Chang LS (August 1996). "The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant".

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Saltzman AG, Morse B, Whitman MM, Ivanshchenko Y, Jaye M, Felder S (December 1991). "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes".

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Millan MJ (2006). "Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies".

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Reynolds GP, Templeman LA, Zhang ZJ (July 2005). "The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment".

7679: 5396:"Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses" 4635:

Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, Kato T (September 2005). "Altered RNA editing of serotonin 2C receptor in a rat model of depression".

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Bubar MJ, Cunningham KA (2006). "Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence".

1507:. Prolonged activation and disturbances of the HPA axis contribute to depressive and anxiety symptoms seen in many psychopathological conditions. 14396: 13546: 6617: 4780:

Niswender CM, Sanders-Bush E, Emeson RB (December 1998). "Identification and characterization of RNA editing events within the 5-HT2C receptor".

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Berg KA, Harvey JA, Spampinato U, Clarke WP (December 2005). "Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors".

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intron but can be an exonic sequence. The region that base pairs with the editing region is known as an Editing Complementary Sequence (ECS).

15004: 13231: 13186: 12894: 9434: 8386: 3774:"Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT 2431: 5226:

Brennan TJ, Seeley WW, Kilgard M, Schreiner CE, Tecott LH (August 1997). "Sound-induced seizures in serotonin 5-HT2c receptor mutant mice".

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Marshall SE, Bird TG, Hart K, Welsh KI (December 1999). "Unified approach to the analysis of genetic variation in serotonergic pathways".

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receptors may have beneficial effects upon certain aspects of depression, one group of researchers found that direct stimulation of 5-HT

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can occur due to A-to-I editing at these sites. Thirty-two different mRNA variants can occur leading to 24 different protein isoforms.

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positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

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Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (March 2005). "Modulation of dopamine release by striatal 5-HT2C receptors".

14359: 12138: 11522: 10679: 7930: 6716: 6711: 1228: 3663:. University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 14 August 2017. 14319: 12150: 11534: 10691: 9289: 7954: 7636: 7631: 7626: 6592: 3137:"Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation" 1235:

receptors by agomelatine results in an increase of dopamine and norepinephrine activity in the frontal cortex. Conversely, many

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acting on RNA (ADARs) that specifically recognize adenosines within double-stranded regions of pre-mRNAs and deaminate them to

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Iwamoto K, Kato T (August 2003). "RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders".

4425:"Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD)" 2784:"RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy" 14328: 7621: 6567: 2396: 1255:

although the delayed mood elevation that is usually typical of SSRIs is usually paralleled by the downregulation of the 5-HT

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Van Oekelen D, Luyten WH, Leysen JE (April 2003). "5-HT2A and 5-HT2C receptors and their atypical regulation properties".

14350: 12098: 11971: 10625: 10485: 8633: 7608: 6257: 1718: 8601: 7513: 6482: 5046:"Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C)" 14815: 14476: 14412: 12064: 12056: 11989: 11477: 11469: 10578: 10570: 10503: 8379: 8182: 8177: 8172: 8167: 8162: 8157: 8152: 8147: 6370: 6165: 6160: 6155: 5791: 4825:

Hoyer D, Hannon JP, Martin GR (April 2002). "Molecular, pharmacological and functional diversity of 5-HT receptors".

1726: 1040: 1531:. In addition, peripheral release of vasopressin involves serotonergic response which is partially mediated via 5-HT 154: 14824: 12052: 11465: 10566: 7964: 7959: 6899: 6894: 5975: 5970: 1302:

receptors may contribute to depressive and anxiety symptoms in a certain population of patients. Activation of 5-HT

12219: 12114: 12060: 11548: 11473: 10762: 10641: 10574: 9638: 8143: 8050: 6904: 6150: 5905: 3880:"Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1" 2400: 1722: 1515: 1373:-mediated conditions in the absence of typical serotonin activity. In addition to the evidence for a role of 5-HT 131: 1342:, and other serotonin receptors. This downregulation parallels the onset of the clinical benefits of SSRIs. 5-HT 14368: 7999: 7994: 7528: 6769: 6764: 6612: 6461: 6456: 774: 4474:"RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms" 4299:"The mRNA expression differences of RNA editing enzymes in differentiated and undifferentiated NG108-15 cells" 12142: 11526: 10683: 7533: 2782:

Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, et al. (May 2001).

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receptors mediate the release and increase of extracellular dopamine in response to many drugs, including

1353:, and may retain the ability to influence neurotransmission in the absence of ligand occupancy. Thus, 5-HT 14730: 12798: 12211: 12102: 11747: 11098: 10629: 9891: 9597: 9093: 7524: 6091: 6086: 5547: 5527: 4596:"Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims" 4513:

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4340:"RNA editing and short variant of serotonin 2C receptor mRNA in neuronally differentiated NG108-15 cells" 2166: 1740: 4218:"Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin2C receptors" 3571:"A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference" 167: 14179: 13754: 13017: 12593: 12185: 11842: 11247: 10736: 8447: 8430: 8413: 6524: 6519: 6375: 6365: 6360: 6345: 6340: 6313: 6139: 6134: 6129: 6040: 5577: 5572: 5567: 5480: 3184:

Esposito E (February 2006). "Serotonin-dopamine interaction as a focus of novel antidepressant drugs".

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3032:. University of North Carolina at Chapel Hill and the United States National Institute of Mental Health 1984: 1714: 1708: 1500: 1284: 1156:

receptors are claimed to significantly regulate mood, anxiety, feeding, and reproductive behavior. 5-HT

1094: 1089:, and in rats is also found in many other brain regions in high concentrations, including parts of the 1025: 2233:

editing can also alter protein function. A to I editing occurs in a non coding RNA sequences such as

160: 15019: 8643: 8638: 8452: 6561: 6556: 6551: 6321: 6207: 6035: 6017: 5998: 5991: 5510: 5445: 1590: 4680:"Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission" 60: 14957: 14748: 14201: 13768: 13060: 12846: 12638: 11277: 8735: 8425: 8116: 7985: 7945: 7591: 6515: 6477: 6336: 6125: 6049: 6003: 5493: 4174:"RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity" 4029:

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3283:"Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation" 1970: 1504: 1390: 907: 903: 852: 844: 81: 15034: 14971: 14938: 14902: 14830: 13948: 13514: 13351: 12836: 12258: 11577: 11426: 10791: 9966: 9651: 9192: 8563: 8535: 8462: 8442: 6849: 6844: 6839: 6834: 6829: 6789: 6784: 6701: 6696: 6691: 6681: 6547: 6431: 6399: 6394: 6356: 6351: 6262: 5986: 1607: 1519: 1272: 1058: 2868:

Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018).

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by the cells translational machinery. There are three members of the ADAR family ADARs 1–3 with

1326:, and others. Some of the initial anxiety caused by SSRIs is due to excessive signalling at 5-HT 928: 899: 873: 848: 14799: 14766: 14630: 13977: 13944: 13586: 13502: 13347: 12904: 12828: 12774: 12337: 12274: 12250: 12017: 11639: 11601: 11569: 11544: 10892: 10807: 10783: 10531: 10320: 10175: 9982: 9978: 9958: 9659: 9643: 9271: 9208: 9188: 8877: 8575: 8548: 6502: 6497: 6414: 6409: 6008: 5609: 5604: 4384:"Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1" 2049: 1659: 1570: 1260: 17: 14835: 14530: 14522: 14219: 13790: 13510: 13050: 12862: 12780: 12652: 12270: 12254: 12013: 12009: 11865: 11597: 11585: 11573: 11287: 10803: 10787: 10527: 10523: 9962: 9647: 8701: 8663: 8543: 8489: 8467: 8420: 8047: 6885: 6869: 6864: 6859: 6825: 6780: 6677: 6540: 6535: 6487: 6390: 6385: 6172: 6056: 5899: 5894: 5889: 5878: 5873: 5868: 5863: 5614: 5599: 5476: 2027: 1358: 1347: 1217: 1210: 3433:

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G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

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receptor stimulation in depressive symptoms there also is evidence that activation of 5-HT

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receptors, but their clinical use is limited by multiple undesirable actions on various

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Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, et al. (July 2020).

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Research indicates that some suicide victims have an abnormally high number of 5-HT

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expression reduces dopamine release in both the presence and absence of stimuli.

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National Center for Biotechnology Information, U.S. National Library of Medicine

2418:

National Center for Biotechnology Information, U.S. National Library of Medicine

1565:

Many human polymorphisms have been identified influencing the expression of 5-HT

1495:

receptor is a significant modulator of the hypothalamic–pituitary–adrenal axis (

14945: 14870: 14227: 14223: 13856: 13794: 13436: 13357: 13181: 13128: 12770: 12744: 12734: 12726: 12656: 12410: 11869: 11697: 11291: 10869: 10731: 10364: 8843: 8798: 8718: 8525: 8395: 8066: 6926: 6754: 5981: 5774: 5769: 5759: 5735: 5705: 5700: 4970: 4678:

Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C (December 2002).

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Herrick-Davis K, Grinde E, Lindsley T, Cowan A, Mazurkiewicz JE (July 2012).

2354: 2022: 2004: 1978: 1974: 1896: 1070: 441: 4190: 4173: 3687: 3402: 3377: 3134: 2517: 464: 412: 64:, 5-HT2C, 5-5HTR1C, 5-HT1C, 5-HT2C receptor, 5-hydroxytryptamine receptor 2C 15039: 14774: 14756: 14690: 14595: 14249: 14235: 14209: 14104: 14094: 14005: 13985: 13938: 13879: 13776: 13689: 13674: 13659: 13606: 13590: 13486: 13411: 13378: 13196: 13078: 12992: 12840: 12672: 12508: 12503: 12463: 12415: 12369: 12353: 12203: 11997: 11797: 11647: 11507: 11442: 11349: 11335: 11307: 11295: 11237: 11188: 11178: 11148: 11128: 11103: 11048: 11019: 11009: 10964: 10932: 10920: 10916: 10900: 10845: 10511: 10431: 10281: 10154: 9952: 9936: 9870: 9686: 9665: 9632: 9587: 9449: 9394: 9294: 9018: 8935: 8881: 8871: 8745: 8510: 8506: 8043: 6441: 6435: 6045: 6030: 5853: 5620: 5421: 5412: 5395: 5386: 5379:

10.1002/(SICI)1096-8628(19991215)88:6<621::AID-AJMG9>3.0.CO;2-H

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10.1002/(SICI)1096-8628(19990416)88:2<126::AID-AJMG6>3.0.CO;2-M

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4409: 4400: 4383: 4365: 4356: 4339: 4324: 4315: 4298: 4283: 4243: 4199: 4143: 4108: 4056: 3905: 3896: 3879: 3864: 3831:

Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties"

3811: 3758: 3695: 3639: 3604: 3555: 3519: 3468: 3411: 3354: 3318: 3267: 3240: 3205: 3170: 3086: 3003: 2946: 2903: 2854: 2809: 2765: 2716: 2589: 2536: 2098: 2078: 2043: 2035: 2016: 1911: 1881: 1823: 1634: 1547: 1460: 1331: 1177: 240: 5290: 5247: 5210: 5173: 5144: 5106: 5069: 5036: 5007: 4999: 4809: 4534: 4216:

Wang Q, O'Brien PJ, Chen CX, Cho DS, Murray JM, Nishikura K (March 2000).

4004: 3946: 3827:"Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT 3121: 3021: 2965: 2673: 2624: 2485: 990: 985: 14951: 14700: 14645: 14195: 14187: 14098: 14090: 14086: 14066: 14054: 14045: 14025: 14013: 13997: 13981: 13819: 13749: 13694: 13664: 13610: 13598: 13482: 13478: 13407: 13328: 13161: 13068: 13045: 13040: 13029: 12987: 12967: 12942: 12927: 12889: 12703: 12668: 12617: 12609: 12583: 12533: 12523: 12473: 12467: 12459: 12455: 12430: 12385: 12377: 12357: 12345: 12332: 12327: 12296: 12154: 12078: 11900: 11854: 11832: 11782: 11772: 11762: 11731: 11691: 11687: 11679: 11659: 11643: 11634: 11538: 11487: 11383: 11315: 11299: 11271: 11263: 11209: 11197: 11168: 11163: 11153: 11133: 11068: 11063: 11052: 11044: 11040: 10984: 10980: 10972: 10956: 10952: 10940: 10936: 10924: 10908: 10873: 10855: 10695: 10613: 10605: 10423: 10419: 10314: 10310: 10216: 10095: 10079: 10018: 9970: 9948: 9944: 9940: 9928: 9920: 9854: 9794: 9790: 9729: 9710: 9628: 9620: 9562: 9532: 9499: 9485: 9374: 9363: 9334: 9279: 9275: 9133: 9123: 9063: 8994: 8981: 8976: 8956: 8931: 8909: 8893: 8847: 8838: 8833: 8740: 8553: 4090: 3152: 2556:

Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology"

2182: 2093: 2065: 2061: 2012: 1988: 1941: 1886: 1861: 1856: 1851: 1836: 1794: 1789: 1779: 1704: 1684: 1649: 1554: 1550:. Combination of the hormones decrease the receptor concentration in the 1476: 1409: 1323: 1307: 1288: 1283:, however, the clinical significance of this action is variable. Several 1192: 1173: 1090: 819: 800: 14738: 14720: 14715: 14710: 14705: 14695: 14585: 14279: 14213: 14124: 14119: 14114: 14109: 14082: 14074: 14058: 14035: 14021: 14017: 14009: 13884: 13837: 13827: 13719: 13714: 13699: 13679: 13618: 13614: 13565: 13560: 13554: 13534: 13466: 13417: 13388: 13383: 13332: 13236: 13206: 13109: 13088: 13007: 13002: 12997: 12977: 12957: 12932: 12916: 12912: 12854: 12790: 12678: 12601: 12538: 12518: 12513: 12493: 12478: 12451: 12439: 12425: 12405: 12395: 12381: 12373: 12365: 12306: 12290: 12286: 12230: 12199: 12189: 12175: 12133: 12128: 12090: 11787: 11757: 11752: 11737: 11727: 11711: 11683: 11675: 11617: 11613: 11517: 11499: 11354: 11323: 11255: 11213: 11205: 11173: 11138: 11108: 11078: 11058: 11036: 11028: 11014: 10999: 10976: 10968: 10960: 10944: 10896: 10860: 10840: 10823: 10819: 10750: 10740: 10721: 10706: 10674: 10669: 10659: 10617: 10341: 10306: 10287: 10261: 10196: 10179: 10169: 10069: 10059: 10029: 10004: 9932: 9924: 9901: 9862: 9831: 9750: 9740: 9714: 9706: 9702: 9698: 9690: 9681: 9624: 9616: 9579: 9552: 9537: 9490: 9469: 9464: 9459: 9429: 9419: 9399: 9384: 9354: 9338: 9322: 9318: 9314: 9298: 9283: 9250: 9245: 9235: 9224: 9212: 9183: 9128: 9118: 9113: 9098: 9078: 9068: 9058: 9002: 8941: 8923: 8905: 8901: 8867: 8855: 8693: 8345: 8261: 7488: 5239: 3652: 3017: 2133: 2128: 2123: 2118: 2108: 2083: 2073: 2057: 1936: 1931: 1921: 1916: 1906: 1891: 1876: 1866: 1809: 1799: 1750: 1736: 1694: 1679: 1674: 1669: 1644: 1624: 1319: 1315: 1240: 1015: 587:

phospholipase C-activating G protein-coupled receptor signaling pathway

139: 89: 14681: 5475: 5297: 3547: 2708: 14877: 14673: 14580: 14273: 14191: 14183: 14169: 14139: 14129: 14001: 13989: 13956: 13929: 13924: 13919: 13874: 13831: 13762: 13758: 13744: 13739: 13734: 13729: 13709: 13602: 13594: 13522: 13497: 13393: 13373: 13342: 13292: 13272: 13257: 13241: 13226: 13221: 13211: 13201: 13191: 13176: 13171: 13166: 13156: 13083: 13025: 13021: 12982: 12952: 12937: 12922: 12908: 12884: 12850: 12813: 12802: 12766: 12694: 12633: 12613: 12597: 12578: 12573: 12568: 12558: 12553: 12543: 12528: 12498: 12361: 12349: 12341: 12262: 12245: 12240: 12235: 12225: 12215: 12193: 12180: 12170: 12165: 12122: 12043: 12038: 12033: 12028: 12005: 12001: 11979: 11975: 11967: 11880: 11860: 11850: 11846: 11837: 11827: 11817: 11812: 11807: 11802: 11792: 11777: 11767: 11742: 11702: 11663: 11651: 11589: 11564: 11559: 11554: 11511: 11456: 11359: 11339: 11331: 11327: 11267: 11251: 11221: 11158: 11123: 11093: 10948: 10928: 10904: 10881: 10877: 10795: 10768: 10758: 10744: 10716: 10711: 10664: 10653: 10584: 10552: 10542: 10519: 10515: 10493: 10489: 10481: 10427: 10415: 10411: 10407: 10346: 10297: 10292: 10256: 10160: 10145: 10112: 10074: 10064: 10054: 10049: 10044: 10039: 10034: 10024: 10009: 9999: 9906: 9836: 9770: 9765: 9755: 9745: 9735: 9720: 9694: 9607: 9602: 9591: 9557: 9444: 9439: 9389: 9344: 9326: 9302: 9255: 9204: 9196: 9173: 9168: 9148: 9143: 9138: 9103: 9083: 9022: 8971: 8961: 8951: 8946: 8919: 8915: 8897: 8885: 8859: 8828: 8723: 8457: 8054: 7975: 5497: 5202: 5098: 3996: 3053:"A review of the pharmacological and clinical profile of mirtazapine" 2825:"Agomelatine versus other antidepressive agents for major depression" 2213: 2103: 2053: 1996: 1992: 1951: 1846: 1774: 1758: 1754: 1730: 1689: 1619: 1614: 1543: 1468: 1464: 1138: 1102: 1021: 676: 206: 193: 109: 97: 5045: 4171: 1369:

constitutive activity, and may prove useful in the treatment of 5-HT

14884: 14794: 14636: 14600: 14460: 14269: 14265: 14243: 14239: 14050: 14029: 13894: 13815: 13798: 13492: 13470: 13454: 13403: 13324: 13054: 12947: 12868: 12818: 12808: 12699: 12664: 12660: 12628: 12435: 12389: 12282: 12094: 12070: 12023: 11896: 11719: 11707: 11609: 11483: 11434: 11421: 11375: 11311: 11303: 11232: 11024: 11004: 10988: 10850: 10815: 10621: 10589: 10537: 10467: 10403: 10399: 10274: 10266: 10220: 10212: 10150: 10108: 10104: 10100: 10014: 9911: 9881: 9846: 9798: 9786: 9725: 9567: 9547: 9542: 9495: 9359: 9349: 9330: 9240: 9230: 9220: 9153: 9073: 9053: 9028: 9006: 8986: 8966: 8927: 8515: 8279: 8257: 5394:

Backstrom JR, Price RD, Reasoner DT, Sanders-Bush E (August 2000).

5265:"Cloning and characterization of MUPP1, a novel PDZ domain protein" 3921:"Cloning and characterization of MUPP1, a novel PDZ domain protein" 3450: 2781: 2648:"Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain" 2194: 2039: 1946: 1766: 1639: 1480: 1436: 1413: 1405: 1401: 1280: 1181: 1161: 1142: 1106: 974: 27:

Serotonin receptor protein distributed mainly in the choroid plexus

5393: 5341: 3716: 3569:

McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011).

14040: 13934: 13889: 13780: 13639: 13634: 13629: 13624: 13550: 13035: 12899: 12858: 12623: 12548: 12301: 12110: 11957: 11875: 11183: 11113: 11083: 10637: 10472: 10461: 10395: 10302: 10165: 9916: 9612: 9424: 9414: 9404: 9163: 9158: 9048: 8497: 7350: 7060: 7055: 7050: 7045: 7040: 7035: 7030: 7025: 7020: 7015: 7010: 7005: 7000: 6995: 6990: 6985: 6980: 6975: 6671: 6666: 6661: 6656: 4765: 4755: 4677: 2234: 2209: 2205: 1784: 1577:. There are indications that the alternative splicing of the 5-HT 1574: 1551: 1417: 1252: 786: 743: 661: 657: 5121: 5014: 4922:

Progress in Neuro-Psychopharmacology & Biological Psychiatry

2498: 2462: 2450:"Entrez Gene: HTR2C 5-hydroxytryptamine (serotonin) receptor 2C" 1514:

receptors leads to increase of corticotropin releasing hormone (

1459:

Serotonin is involved in basal and stress-induced regulation of

1361:(serotonin) in order to exhibit influence on neurotransmission. 562:

positive regulation of phosphatidylinositol biosynthetic process

77: 15014: 14615: 13914: 13704: 13530: 13526: 13267: 12311: 12160: 12086: 12074: 11953: 11949: 10778: 10701: 10609: 10597: 10593: 10557: 10457: 10453: 9454: 8232: 8227: 8222: 8217: 8207: 8202: 8197: 8188: 8133: 8128: 8090: 8085: 8080: 8042: 7925: 7901: 7896: 7891: 7886: 7881: 7876: 7871: 7866: 7861: 7856: 7851: 7846: 7841: 7836: 7831: 7826: 7821: 7743: 7738: 7733: 7728: 7665: 7660: 7655: 7563: 7508: 7503: 7498: 7469: 7450: 7445: 7440: 7435: 7430: 7425: 7420: 7415: 7410: 7405: 7400: 7395: 7390: 7385: 7380: 7375: 7370: 7365: 7360: 7355: 7345: 7340: 7335: 7330: 7310: 6970: 6965: 6960: 6955: 6950: 6945: 6940: 6651: 6646: 6641: 6636: 6601: 6292: 6115: 6109: 5679: 5674: 5664: 5659: 4381: 3568: 3331: 2867: 2225: 2221: 1804: 1654: 1024:(5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, it is a 958: 698: 552:

phospholipase C-activating serotonin receptor signaling pathway

421: 4985: 4031:"Messenger RNA editing of the human serotonin 5-HT2C receptor" 2922:"Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)" 2258:

An Isoleucine to Valine (I/V) at amino acid position 157,161.

13909: 13904: 13151: 13072: 10773: 10726: 9108: 8328: 8019: 8014: 7816: 7811: 7806: 7801: 7777: 7723: 7718: 7713: 7558: 7553: 7543: 7538: 7479: 7305: 7300: 7295: 7290: 7285: 7280: 7275: 7270: 7265: 7260: 7255: 7250: 7245: 7240: 7235: 7230: 7225: 7220: 7215: 7210: 7205: 7200: 7195: 7190: 7185: 7180: 7175: 7170: 7165: 7160: 7155: 7150: 7145: 7140: 7135: 7130: 7125: 7120: 7115: 7110: 6631: 6596: 6446: 6286: 6281: 6276: 6271: 6266: 6252: 6246: 6241: 6236: 6231: 6226: 6221: 6216: 6211: 6201: 6196: 6191: 6186: 6181: 6176: 6144: 6104: 6099: 6022: 5934: 5929: 5924: 5919: 5914: 5909: 5669: 5654: 5649: 5644: 5639: 5634: 5629: 5624: 5225: 4634: 2740:"Serotonin 5-HT(2C) receptors regulate anxiety-like behavior" 2261:

An Isoleucine to a Methionine(I/M) at amino acid position 157

2242: 1744: 1629: 1051: 383: 261: 5327: 4750:

Overview of all the structural information available in the

4512: 3481: 3432: 15050:

University of Florida Obsessive–Compulsive Disorder Program

13538: 12146: 11945: 11941: 11937: 11530: 10687: 10449: 10445: 10441: 9409: 8323: 8318: 8313: 8308: 8303: 8298: 8293: 8288: 8283: 7701: 7694: 7689: 7684: 7493: 7483: 7105: 7100: 7095: 7090: 6750: 6626: 6120: 4779: 4296: 4028: 3280: 2738:

Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007).

2217: 2170: 1472: 1295:

antagonists; this action may contribute to their efficacy.

1054: 8255: 4861: 4422: 3672: 3100:

Frazer A (April 1997). "Pharmacology of antidepressants".

2981: 2694: 14620: 13898: 13474: 13336: 12106: 12048: 11461: 10633: 10562: 9866: 9010: 7518: 5262: 4297:

Sukma M, Tohda M, Watanabe H, Matsumoto K (August 2005).

3918: 3676:

The Journal of Pharmacology and Experimental Therapeutics

1439:

levels in the human body may have potential to raise 5-HT

39: 8394: 5180: 4593: 4121: 3974: 3877: 3532: 2822: 2197:

of the 5HT2CR is Adenosine to Inosine (A to I) editing.

1542:

receptor in the CNS is modulated by female sex hormones

1447:

gene expression, resulting in increased activity of 5-HT

1121:

receptors are also found on epithelial cells lining the

230: 4890: 4073:

Flomen R, Knight J, Sham P, Kerwin R, Makoff A (2004).

2549: 607:

regulation of corticotropin-releasing hormone secretion

5263:

Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998).

5043: 4919: 4215: 4072: 3919:

Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998).

3824: 3717:

De Deurwaerdère P, Chagraoui A, Cunningham KA (2020).

2602: 5364: 1330:. Over a period of 1–2 weeks, the receptor begins to 1306:

by serotonin is responsible for many of the negative

395: 5076: 3771: 3723:

Receptor Function and Its Pharmacological Targeting"

1141:. Activation of this receptor by serotonin inhibits 455:

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

5017:

Biochemical and Biophysical Research Communications

4261: 2737: 1073:. The crystal structure has been known since 2018. 4337: 2392: 2390: 2388: 1389:agonist reduced cognitive deficits in mice with a 1251:activity by increasing levels of serotonin in the 14411: 8786: 4824: 4471: 3617: 2145:Exogenous PAMs binding at the receptor vestibule 177: 15062: 1499:). The HPA axis is the main controller of acute 5151: 4546: 4544: 4377: 4375: 4257: 4255: 4253: 4211: 4209: 4167: 4165: 4163: 4161: 4068: 4066: 4024: 4022: 3218: 3050: 2977: 2975: 2777: 2775: 2385: 2200:A to I RNA editing is catalyzed by a family of 1279:antagonist in addition to inhibiting serotonin 617:positive regulation of fat cell differentiation 542:release of sequestered calcium ion into cytosol 4472:Marion S, Weiner DM, Caron MG (January 2004). 3970: 3968: 3966: 3964: 3962: 3960: 3958: 3956: 2915: 2913: 2397:GRCm38: Ensembl release 89: ENSMUSG00000041380 1483:, mainly via actions of receptor subtypes 5-HT 1137:receptor is one of the many binding sites for 14397: 11194:Serotonin antagonists and reuptake inhibitors 8772: 8380: 5461: 4338:Tohda M, Sukma M, Watanabe H (October 2004). 2224:being the only enzymatically active members. 1069:At the cell surface the receptor exists as a 470:G protein-coupled serotonin receptor activity 14672: 4671: 4628: 4587: 4541: 4465: 4372: 4331: 4290: 4250: 4206: 4158: 4115: 4063: 4019: 3871: 3818: 3765: 3719:"Editorial: Contemporary Perspective on 5-HT 3710: 3666: 3526: 3475: 3426: 3375: 3369: 3325: 3274: 3247: 3212: 3177: 3128: 2972: 2772: 2731: 2688: 2645: 632:G protein-coupled receptor signaling pathway 602:positive regulation of ERK1 and ERK2 cascade 14449: 5492: 4550: 4506: 3953: 3912: 3093: 2910: 2829:The Cochrane Database of Systematic Reviews 2543: 2492: 2193:The type of RNA editing that occurs in the 1589:, the deletion of which is associated with 1160:receptors regulate dopamine release in the 15030:Relationship obsessive–compulsive disorder 14404: 14390: 8779: 8765: 8387: 8373: 7590: 5468: 5454: 5433:United States National Library of Medicine 4782:Annals of the New York Academy of Sciences 3661:Psychoactive Drug Screening Program (PDSP) 3030:Psychoactive Drug Screening Program (PDSP) 2456: 15005:Obsessive–compulsive personality disorder 5411: 5280: 4764:(5-hydroxytryptamine receptor 2C) at the 4705: 4695: 4611: 4489: 4440: 4399: 4355: 4314: 4233: 4189: 4098: 4046: 3936: 3895: 3854: 3801: 3748: 3738: 3594: 3509: 3499: 3458: 3401: 3308: 3298: 3253: 3160: 3076: 2955: 2945: 2893: 2844: 2799: 2755: 2663: 2579: 2526: 2516: 475:Gq/11-coupled serotonin receptor activity 5431:This article incorporates text from the 4827:Pharmacology, Biochemistry, and Behavior 4264:Brain Research. Molecular Brain Research 3183: 2919: 2140: 1365:may be required to fully extinguish 5-HT 14683:Selective serotonin reuptake inhibitors 3044: 3016: 2861: 2816: 2270:An Asparagine to a Glycine(N/G) at 159. 1334:, along with the downregulation of 5-HT 1149:release in certain areas of the brain. 14: 15063: 14427:Dimensional Obsessive-Compulsive Scale 6618:Luteinizing hormone/choriogonadotropin 4956: 3102:Journal of Clinical Psychopharmacology 3099: 2267:An Aspartate to Asparagine(N/D) at 159 2181:5HT2CR pre-mRNA can be the subject of 1357:receptors do not require binding by a 14432:Yale–Brown Obsessive Compulsive Scale 14385: 8760: 8368: 8254: 8041: 7622:Brain-specific angiogenesis inhibitor 7589: 5491: 5449: 3221:Current Topics in Medicinal Chemistry 2442: 1247:antagonist) indirectly stimulate 5-HT 516:integral component of plasma membrane 182: 143: 138: 12708:methylergometrine (methylergonovine) 11668:N-desalkylquetiapine (norquetiapine) 11504:methylergometrine (methylergonovine) 10650:methylergometrine (methylergonovine) 10279:methylergometrine (methylergonovine) 10225:methylergometrine (methylergonovine) 9584:methylergometrine (methylergonovine) 9015:methylergometrine (methylergonovine) 5367:American Journal of Medical Genetics 5301:American Journal of Medical Genetics 3010: 2374:Norepinephrine-dopamine disinhibitor 2369:Anxiety/Aggression-Driven Depression 2264:An Aspartate to a Serine (N/S)at 159 1557:in rats and could thus affect mood. 1229:norepinephrine-dopamine disinhibitor 1191:receptors in the prefrontal cortex. 1085:receptors are located mainly in the 592:serotonin receptor signaling pathway 577:regulation of nervous system process 11672:N-desmethylclozapine (norclozapine) 8634:Transcription preinitiation complex 5400:The Journal of Biological Chemistry 4478:The Journal of Biological Chemistry 4388:The Journal of Biological Chemistry 4344:Journal of Pharmacological Sciences 4303:Journal of Pharmacological Sciences 4178:The Journal of Biological Chemistry 3884:The Journal of Biological Chemistry 3376:Kishore S, Stamm S (January 2006). 2505:The Journal of Biological Chemistry 1958: 1817: 460:G protein-coupled receptor activity 24: 8602:Signal transducing adaptor protein 4802:10.1111/j.1749-6632.1998.tb10171.x 4772: 4697:10.1523/JNEUROSCI.22-24-10529.2002 4515:Trends in Pharmacological Sciences 3069:10.1111/j.1527-3458.2001.tb00198.x 2984:Trends in Pharmacological Sciences 2646:Hoffman BJ, Mezey E (April 1989). 1275:. Fluoxetine acts as a direct 5-HT 521:intracellular anatomical structure 485:neurotransmitter receptor activity 25: 15092: 14816:Acceptance and commitment therapy 14477:Brain-derived neurotrophic factor 4725: 4276:10.1016/j.molbrainres.2004.02.010 4235:10.1046/j.1471-4159.2000.741290.x 14825:Exposure and response prevention 7971:Growth-hormone-releasing hormone 5125:European Journal of Pharmacology 3632:10.1111/j.1743-6109.2010.02032.x 3114:10.1097/00004714-199704001-00002 3051:Anttila SA, Leinonen EV (2001). 2757:10.1111/j.1601-183X.2007.00316.x 2466:European Journal of Pharmacology 1454: 567:cellular calcium ion homeostasis 411: 404: 362:dorsomedial hypothalamic nucleus 166: 159: 153: 130: 38: 14360:Monoamine metabolism modulators 7931:Corticotropin-releasing hormone 4864:Pharmacology & Therapeutics 4416: 3646: 3611: 3562: 2304: 2278: 2156: 1471:, adrenocorticotropic hormone ( 1076: 6593:Gonadotropin-releasing hormone 3835:Journal of Medicinal Chemistry 3782:Journal of Medicinal Chemistry 3620:The Journal of Sexual Medicine 3536:Journal of Medicinal Chemistry 3300:10.1523/JNEUROSCI.2584-06.2007 2920:Ni YG, Miledi R (March 1997). 2837:10.1002/14651858.CD008851.pub2 2639: 2596: 2424: 2406: 2176: 1829: 1518:) and vasopressin mRNA in the 627:chemical synaptic transmission 501:integral component of membrane 422:More reference expression data 384:More reference expression data 300:Region I of hippocampus proper 13: 1: 15076:Obsessive–compulsive disorder 14413:Obsessive–compulsive disorder 14347:Monoamine reuptake inhibitors 14311:Receptor/signaling modulators 8011:Vasoactive intestinal peptide 6881:Thyrotropin-releasing hormone 5282:10.1016/S0014-5793(98)00141-0 4905:10.1016/S0024-3205(03)00141-3 4876:10.1016/S0163-7258(01)00169-3 4839:10.1016/S0091-3057(01)00746-8 4613:10.1016/S0896-6273(02)00660-8 4565:10.1016/S0304-3940(03)00608-6 4527:10.1016/S0165-6147(00)88991-9 4442:10.1016/S0893-133X(99)00005-6 4048:10.1016/S0893-133X(99)00004-4 3938:10.1016/S0014-5793(98)00141-0 3347:10.1016/S0304-3940(01)02570-8 2886:10.1016/S0140-6736(17)32802-7 2801:10.1016/S0893-133X(00)00223-2 2379: 2287: 151: 14821:Cognitive behavioral therapy 14731:Monoamine oxidase inhibitors 5137:10.1016/0922-4106(94)90042-6 5029:10.1016/0006-291X(91)92105-S 4649:10.1016/j.neures.2005.06.001 4136:10.1016/j.neures.2006.02.005 3847:10.1021/acs.jmedchem.9b01953 3794:10.1021/acs.jmedchem.8b00401 3587:10.1016/j.neulet.2011.07.036 2665:10.1016/0014-5793(89)81390-0 2617:10.1016/0028-3908(95)00138-7 2478:10.1016/0922-4106(94)90042-6 1503:stress responses related to 1064: 334:Epithelium of choroid plexus 7: 14180:Tetracyclic antidepressants 13755:Tetracyclic antidepressants 13018:Tetracyclic antidepressants 12594:Tetracyclic antidepressants 11843:Tetracyclic antidepressants 11248:Tetracyclic antidepressants 6796:Prolactin-releasing peptide 5481:G protein-coupled receptors 4934:10.1016/j.pnpbp.2005.03.019 4684:The Journal of Neuroscience 3287:The Journal of Neuroscience 2348: 2284:conserved across Mammalia. 2248: 2165:receptor has been shown to 1601: 1581:receptor is regulated by a 1560: 1393:loss-of-function mutation. 1285:tetracyclic antidepressants 1128: 276:superior vestibular nucleus 10: 15097: 4743:gene details page in the 3233:10.2174/156802606778522131 3198:10.2174/138945006775515455 2996:10.1016/j.tips.2005.10.008 2572:10.1016/j.cell.2018.01.001 1605: 1596: 1231:because antagonism of 5-HT 1095:anterior olfactory nucleus 1028:(GPCR) that is coupled to 1026:G protein-coupled receptor 465:signal transducer activity 15020:Primarily Obsessional OCD 14985: 14923: 14894: 14862: 14855: 14848: 14808: 14787: 14765: 14749:Tricyclic antidepressants 14747: 14729: 14665: 14559: 14485: 14440: 14419: 14301: 14258: 14202:Tricyclic antidepressants 14120:Metitepine (methiothepin) 13970: 13867: 13855: 13808: 13769:Tricyclic antidepressants 13700:Metitepine (methiothepin) 13574: 13447: 13435: 13384:Metitepine (methiothepin) 13366: 13317: 13305: 13250: 13139: 13127: 13097: 12877: 12755: 12743: 12725: 12687: 12639:Tricyclic antidepressants 12514:Metitepine (methiothepin) 12320: 11926: 11914: 11889: 11758:Metitepine (methiothepin) 11627: 11409: 11397: 11368: 11278:Tricyclic antidepressants 11109:Metitepine (methiothepin) 10833: 10387: 10375: 10363: 10342:Metitepine (methiothepin) 10334: 10249: 10237: 10205: 10197:Metitepine (methiothepin) 10189: 10138: 10126: 10088: 10060:Metitepine (methiothepin) 9992: 9824: 9812: 9779: 9751:Metitepine (methiothepin) 9674: 9525: 9513: 9478: 9400:Metitepine (methiothepin) 9264: 8821: 8809: 8797: 8686: 8656: 8619: 8594: 8571: 8562: 8534: 8488: 8481: 8406: 8338: 8272: 8268: 8250: 8107: 8065: 8061: 8037: 7911: 7788: 7607: 7603: 7585: 7460: 7077: 6925: 6918: 6424: 6312: 6305: 6070: 5957: 5948: 5784: 5689: 5586: 5518: 5509: 5505: 5487: 4222:Journal of Neurochemistry 3740:10.3389/fphar.2020.606414 3727:Frontiers in Pharmacology 2744:Genes, Brain and Behavior 2432:"Mouse PubMed Reference:" 2414:"Human PubMed Reference:" 1451:receptors in the brain . 1435:Conditions that increase 1223:agonist, is an effective 989: 984: 980: 973: 957: 951:Chr X: 145.75 – 145.98 Mb 940: 925: 921: 896: 892: 885: 870: 866: 841: 837: 830: 817: 813: 798: 794: 785: 772: 768: 755: 751: 742: 729: 725: 710: 706: 697: 682: 675: 671: 655: 582:cGMP biosynthetic process 440: 436: 419: 403: 394: 381: 366:medial vestibular nucleus 330: 321: 268: 259: 229: 221: 217: 200: 187: 150: 129: 120: 116: 71: 68: 58: 51: 46: 37: 32: 13690:Latrepirdine (dimebolin) 13379:Latrepirdine (dimebolin) 12704:ergometrine (ergonovine) 12504:Latrepirdine (dimebolin) 11901:ergometrine (ergonovine) 10614:ergometrine (ergonovine) 10217:ergometrine (ergonovine) 9795:ergometrine (ergonovine) 9500:ergometrine (ergonovine) 8714:Neuroendocrine signaling 8117:Calcium-sensing receptor 7986:Methuselah-like proteins 4988:Human Molecular Genetics 4971:10.2515/therapie:2005065 3501:10.3389/fpsyt.2017.00089 1505:fight-or-flight response 572:behavioral fear response 358:dorsal tegmental nucleus 350:anterior amygdaloid area 272:external globus pallidus 15035:Social anxiety disorder 14903:Everything in Its Place 14831:Inference-based therapy 14767:Atypical antipsychotics 13978:Atypical antipsychotics 13587:Atypical antipsychotics 12905:Atypical antipsychotics 12338:Atypical antipsychotics 11640:Atypical antipsychotics 10893:Atypical antipsychotics 9272:Atypical antipsychotics 8878:Atypical antipsychotics 6263:Sphingosine-1-phosphate 6151:Hydroxycarboxylic acids 4429:Neuropsychopharmacology 4191:10.1074/jbc.274.14.9472 4035:Neuropsychopharmacology 3688:10.1124/jpet.111.187534 3488:Frontiers in Psychiatry 3403:10.1126/science.1118265 3256:Danish Medical Bulletin 3141:Neuropsychopharmacology 2788:Neuropsychopharmacology 2518:10.1074/jbc.M112.350249 2188: 1608:5-HT2C receptor agonist 1571:substance use disorders 1520:paraventricular nucleus 1298:An overactivity of 5-HT 1261:atypical antipsychotics 1227:. It has been called a 642:cGMP-mediated signaling 14800:Deep brain stimulation 14631:Experiential avoidance 14220:Typical antipsychotics 13791:Typical antipsychotics 13051:Typical antipsychotics 12933:Bemesetron (MDL-72222) 12653:Typical antipsychotics 11866:Typical antipsychotics 11288:Typical antipsychotics 9979:5-(nonyloxy)tryptamine 8576:cAMP-dependent pathway 8144:Metabotropic glutamate 5413:10.1074/jbc.M000922200 5166:10.1006/geno.1996.0397 5062:10.1006/geno.1995.1042 4491:10.1074/jbc.M308742200 4401:10.1074/jbc.M311347200 4357:10.1254/jphs.FP0040227 4316:10.1254/jphs.SC0050074 4079:Nucleic Acids Research 3897:10.1074/jbc.M008089200 2947:10.1073/pnas.94.5.2036 1660:Naphthylisopropylamine 1538:Expression of the 5-HT 612:regulation of appetite 342:lateral septal nucleus 14836:Metacognitive therapy 14369:Monoamine neurotoxins 12147:MDMA (midomafetamine) 11531:MDMA (midomafetamine) 11134:Opiranserin (VVZ-149) 10688:MDMA (midomafetamine) 10394:25H/NB series (e.g., 8702:Synaptic transmission 8698:Neurocrine signaling 8621:Transcription factors 8468:PI3K/AKT/mTOR pathway 6173:Lysophosphatidic acid 5477:Cell surface receptor 4637:Neuroscience Research 4124:Neuroscience Research 2141:Allosteric Modulators 1591:Prader–Willi syndrome 1491:. Therefore, the 5-HT 1385:receptors with a 5-HT 1348:constitutive activity 1314:medications, such as 338:medial dorsal nucleus 15010:Obsessional jealousy 14467:Orbitofrontal cortex 12841:bufotenidine (5-HTQ) 11964:5-Methoxytryptamines 10478:5-Methoxytryptamines 8098:Vomeronasal receptor 7068:Vomeronasal receptor 4737:genome location and 4553:Neuroscience Letters 4435:(2 Suppl): 77S–81S. 4041:(2 Suppl): 82S–90S. 3655:, Driscol J. "PDSP K 3575:Neuroscience Letters 3335:Neuroscience Letters 3186:Current Drug Targets 3153:10.1038/npp.2013.313 2880:(10128): 1357–1366. 2239:untranslated regions 2202:adenosine deaminases 1010:is a subtype of the 354:lateral hypothalamus 288:middle frontal gyrus 184:X F2|X 68.46 cM 145:X chromosome (mouse) 15081:Serotonin receptors 15000:Illusion of control 14627:Thought suppression 13459:dihydroergocryptine 12143:MDA (tenamfetamine) 11527:MDA (tenamfetamine) 11492:dihydroergocryptine 10684:MDA (tenamfetamine) 8731:Mechanotransduction 8719:Exocrine signalling 8526:Signaling molecules 8400:Signal transduction 7991:Parathyroid hormone 5951:signaling molecules 5406:(31): 23620–23626. 5195:1997Natur.387..303B 5091:1995Natur.374..542T 5000:10.1093/hmg/1.9.681 4794:1998NYASA.861...38N 4745:UCSC Genome Browser 4690:(24): 10529–10532. 3989:1997Natur.387..303B 3890:(16): 12974–12982. 3394:2006Sci...311..230K 3108:(Suppl 1): 2S–18S. 2938:1997PNAS...94.2036N 2511:(28): 23604–23614. 1902:O-Desmethyltramadol 1812:also 5HT2a agonist. 1510:Stimulation of 5-HT 1111:subthalamic nucleus 622:signal transduction 557:locomotory behavior 15025:Questionable cause 14932:As Good as It Gets 14284:naphthylpiperazine 14055:2-Br-LSD (BOL-148) 13842:naphthylpiperazine 13820:2-Br-LSD (BOL-148) 13422:naphthylpiperazine 13329:2-Br-LSD (BOL-148) 13114:naphthylpiperazine 11990:α-Alkyltryptamines 10504:α-Alkyltryptamines 8788:Serotonin receptor 8741:Ion channel gating 8473:Integrin receptors 8407:Signaling pathways 8140:Glutamate receptor 7525:Protease-activated 5435:, which is in the 5240:10.1038/ng0897-387 4091:10.1093/nar/gkh536 2566:(4): 719–730.e14. 2212:are recognised as 1420:, and others. 5-HT 1346:receptors exhibit 775:ENSMUSG00000041380 535:Biological process 494:Cellular component 448:Molecular function 370:olfactory tubercle 15058: 15057: 15045:Tourette syndrome 14981: 14980: 14919: 14918: 14844: 14843: 14783: 14782: 14555: 14554: 14379: 14378: 14372: 14363: 14354: 14341: 14332: 14323: 14314: 14297: 14296: 14293: 14292: 14263:Unknown/unsorted: 14071:dihydroergotamine 13851: 13850: 13813:Unknown/unsorted: 13463:dihydroergotamine 13431: 13430: 13401:Unknown/unsorted: 13301: 13300: 13123: 13122: 13102:Unknown/unsorted: 12771:ethanol (alcohol) 12721: 12720: 12717: 12716: 12692:Unknown/unsorted: 12083:dihydroergotamine 11910: 11909: 11894:Unknown/unsorted: 11496:dihydroergotamine 11393: 11392: 11380:dihydroergotamine 11373:Unknown/unsorted: 11202:hydroxynefazodone 10359: 10358: 10355: 10354: 10233: 10232: 10210:Unknown/unsorted: 10122: 10121: 10093:Unknown/unsorted: 9859:dihydroergotamine 9808: 9807: 9784:Unknown/unsorted: 9576:dihydroergotamine 9509: 9508: 9483:Unknown/unsorted: 9311:iodocyanopindolol 8999:dihydroergotamine 8852:hydroxynefazodone 8754: 8753: 8736:Phototransduction 8694:Intracrine action 8652: 8651: 8615: 8614: 8503:Neurotransmitters 8362: 8361: 8358: 8357: 8354: 8353: 8246: 8245: 8242: 8241: 8033: 8032: 8029: 8028: 7581: 7580: 7577: 7576: 7573: 7572: 6914: 6913: 6301: 6300: 5944: 5943: 5189:(6630): 303–308. 5085:(6522): 542–546. 4899:(22): 2429–2449. 4184:(14): 9472–9478. 3983:(6630): 303–308. 3841:(14): 7529–7544. 3548:10.1021/jm5003292 3542:(12): 5258–5269. 3388:(5758): 230–232. 3293:(26): 6956–6964. 3227:(18): 1971–1985. 2709:10.1002/syn.20109 2611:(12): 1635–1645. 2605:Neuropharmacology 1467:hormones such as 1428:. Increased 5-HT 1291:, are potent 5-HT 1269:neurotransmitters 1243:, which is a 5-HT 1195:, which is a 5-HT 1170:nucleus accumbens 1166:prefrontal cortex 1057:encoding for the 1044:neurotransmission 1000: 999: 996: 995: 969: 968: 936: 935: 915: 914: 881: 880: 860: 859: 826: 825: 807: 806: 781: 780: 762: 761: 738: 737: 719: 718: 667: 666: 480:serotonin binding 432: 431: 428: 427: 390: 389: 377: 376: 346:nucleus accumbens 315: 314: 308:entorhinal cortex 280:nucleus accumbens 213: 212: 110:HTR2C - orthologs 16:(Redirected from 15088: 14860: 14859: 14853: 14852: 14679: 14678: 14670: 14669: 14472:Cingulate cortex 14447: 14446: 14406: 14399: 14392: 14383: 14382: 14366: 14357: 14351:releasing agents 14344: 14335: 14326: 14317: 14305: 13930:Serotonin (5-HT) 13865: 13864: 13498:Serotonin (5-HT) 13445: 13444: 13343:Serotonin (5-HT) 13315: 13314: 13222:Serotonin (5-HT) 13137: 13136: 12973:Hydroxybupropion 12814:Serotonin (5-HT) 12775:trichloroethanol 12753: 12752: 12741: 12740: 12246:Serotonin (5-HT) 11924: 11923: 11565:Serotonin (5-HT) 11447:levofenfluramine 11431:chlorphentermine 11417:4-Methylaminorex 11407: 11406: 11320:prochlorperazine 11144:Phenoxybenzamine 11114:MIN-117 (WF-516) 10769:Serotonin (5-HT) 10385: 10384: 10373: 10372: 10298:Serotonin (5-HT) 10247: 10246: 10161:Serotonin (5-HT) 10136: 10135: 9907:Serotonin (5-HT) 9822: 9821: 9608:Serotonin (5-HT) 9523: 9522: 9405:MIN-117 (WF-516) 9174:Serotonin (5-HT) 8819: 8818: 8807: 8806: 8781: 8774: 8767: 8758: 8757: 8707:Chemical synapse 8607:Scaffold protein 8569: 8568: 8564:Second messenger 8490:Receptor ligands 8486: 8485: 8389: 8382: 8375: 8366: 8365: 8270: 8269: 8252: 8251: 8063: 8062: 8039: 8038: 7605: 7604: 7587: 7586: 6923: 6922: 6310: 6309: 6208:Lysophospholipid 5955: 5954: 5516: 5515: 5511:Neurotransmitter 5507: 5506: 5489: 5488: 5470: 5463: 5456: 5447: 5446: 5425: 5415: 5390: 5361: 5324: 5294: 5284: 5259: 5222: 5203:10.1038/387303a0 5177: 5148: 5118: 5099:10.1038/374542a0 5073: 5040: 5023:(3): 1469–1478. 5011: 4982: 4953: 4928:(6): 1021–1028. 4916: 4887: 4870:(2–3): 179–212. 4858: 4821: 4720: 4719: 4709: 4699: 4675: 4669: 4668: 4632: 4626: 4625: 4615: 4591: 4585: 4584: 4548: 4539: 4538: 4510: 4504: 4503: 4493: 4484:(4): 2945–2954. 4469: 4463: 4462: 4444: 4420: 4414: 4413: 4403: 4394:(6): 4894–4902. 4379: 4370: 4369: 4359: 4335: 4329: 4328: 4318: 4294: 4288: 4287: 4259: 4248: 4247: 4237: 4228:(3): 1290–1300. 4213: 4204: 4203: 4193: 4169: 4156: 4155: 4119: 4113: 4112: 4102: 4085:(7): 2113–2122. 4070: 4061: 4060: 4050: 4026: 4017: 4016: 3997:10.1038/387303a0 3972: 3951: 3950: 3940: 3916: 3910: 3909: 3899: 3875: 3869: 3868: 3858: 3822: 3816: 3815: 3805: 3769: 3763: 3762: 3752: 3742: 3714: 3708: 3707: 3670: 3664: 3650: 3644: 3643: 3615: 3609: 3608: 3598: 3566: 3560: 3559: 3530: 3524: 3523: 3513: 3503: 3479: 3473: 3472: 3462: 3430: 3424: 3423: 3405: 3373: 3367: 3366: 3329: 3323: 3322: 3312: 3302: 3278: 3272: 3271: 3251: 3245: 3244: 3216: 3210: 3209: 3181: 3175: 3174: 3164: 3147:(5): 1125–1134. 3132: 3126: 3125: 3097: 3091: 3090: 3080: 3057:CNS Drug Reviews 3048: 3042: 3041: 3039: 3037: 3014: 3008: 3007: 2979: 2970: 2969: 2959: 2949: 2932:(5): 2036–2040. 2917: 2908: 2907: 2897: 2865: 2859: 2858: 2848: 2831:(12): CD008851. 2820: 2814: 2813: 2803: 2779: 2770: 2769: 2759: 2735: 2729: 2728: 2692: 2686: 2685: 2667: 2643: 2637: 2636: 2600: 2594: 2593: 2583: 2547: 2541: 2540: 2530: 2520: 2496: 2490: 2489: 2460: 2454: 2453: 2446: 2440: 2439: 2428: 2422: 2421: 2410: 2404: 2394: 1959:Inverse agonists 1818:Partial agonists 1363:Inverse agonists 1259:receptors. Many 1184:, among others. 1115:lateral habenula 1099:substantia nigra 1019:neurotransmitter 982: 981: 953: 946: 931: 919: 918: 910: 890: 889: 886:RefSeq (protein) 876: 864: 863: 855: 835: 834: 811: 810: 792: 791: 766: 765: 749: 748: 723: 722: 704: 703: 673: 672: 637:animal behaviour 597:feeding behavior 438: 437: 424: 415: 408: 401: 400: 386: 326: 324:Top expressed in 319: 318: 304:endothelial cell 264: 262:Top expressed in 257: 256: 236: 235: 219: 218: 209: 196: 185: 170: 163: 157: 146: 134: 118: 117: 112: 63: 56: 42: 30: 29: 21: 15096: 15095: 15091: 15090: 15089: 15087: 15086: 15085: 15061: 15060: 15059: 15054: 14995:Guilt (emotion) 14977: 14915: 14890: 14849:Popular culture 14840: 14804: 14779: 14761: 14743: 14725: 14661: 14551: 14542: 14534: 14526: 14513: 14505: 14496: 14481: 14436: 14415: 14410: 14380: 14375: 14289: 14254: 14232:chlorprothixene 13966: 13860: 13847: 13804: 13570: 13440: 13427: 13362: 13310: 13297: 13246: 13132: 13119: 13093: 13061:Volatiles/gases 12873: 12863:trichloroethane 12847:Volatiles/gases 12786:Phenylbiguanide 12748: 12737: 12730: 12713: 12683: 12316: 12186:Phenethylamines 11919: 11906: 11885: 11623: 11451:norfenfluramine 11439:dexfenfluramine 11402: 11389: 11364: 11344:trifluoperazine 10995:Chlorprothixene 10829: 10737:Phenethylamines 10548:Bromo-DragonFLY 10380: 10368: 10351: 10330: 10242: 10229: 10201: 10185: 10131: 10118: 10084: 9988: 9817: 9804: 9775: 9670: 9518: 9505: 9474: 9260: 8844:Antidepressants 8814: 8802: 8793: 8785: 8755: 8750: 8682: 8648: 8611: 8590: 8586:Lipid signaling 8558: 8530: 8477: 8402: 8393: 8363: 8350: 8334: 8264: 8238: 8125: 8103: 8057: 8025: 7907: 7784: 7599: 7569: 7456: 7073: 6910: 6516:Cholecystokinin 6420: 6297: 6126:Free fatty acid 6066: 5950: 5949:Metabolites and 5940: 5780: 5685: 5582: 5501: 5483: 5474: 5443: 5428: 5330:Nature Genetics 5228:Nature Genetics 4775: 4773:Further reading 4728: 4723: 4676: 4672: 4633: 4629: 4592: 4588: 4549: 4542: 4511: 4507: 4470: 4466: 4421: 4417: 4380: 4373: 4336: 4332: 4295: 4291: 4260: 4251: 4214: 4207: 4170: 4159: 4120: 4116: 4071: 4064: 4027: 4020: 3973: 3954: 3917: 3913: 3876: 3872: 3830: 3823: 3819: 3777: 3770: 3766: 3722: 3715: 3711: 3671: 3667: 3658: 3651: 3647: 3616: 3612: 3567: 3563: 3531: 3527: 3480: 3476: 3439:Nature Genetics 3431: 3427: 3374: 3370: 3330: 3326: 3279: 3275: 3252: 3248: 3217: 3213: 3182: 3178: 3133: 3129: 3098: 3094: 3049: 3045: 3035: 3033: 3025: 3015: 3011: 2990:(12): 625–630. 2980: 2973: 2918: 2911: 2866: 2862: 2821: 2817: 2780: 2773: 2736: 2732: 2693: 2689: 2644: 2640: 2601: 2597: 2555: 2548: 2544: 2497: 2493: 2461: 2457: 2448: 2447: 2443: 2430: 2429: 2425: 2412: 2411: 2407: 2395: 2386: 2382: 2363: 2351: 2307: 2295: 2290: 2281: 2251: 2191: 2179: 2164: 2159: 2143: 2138: 1966:Antidepressants 1961: 1956: 1832: 1820: 1815: 1715:Phenethylamines 1665:Norfenfluramine 1610: 1604: 1599: 1580: 1568: 1563: 1541: 1534: 1530: 1526: 1513: 1494: 1490: 1486: 1465:pituitary gland 1457: 1450: 1446: 1442: 1431: 1427: 1423: 1399: 1388: 1384: 1380: 1376: 1372: 1368: 1356: 1345: 1341: 1337: 1329: 1305: 1301: 1294: 1278: 1266: 1258: 1250: 1246: 1234: 1221: 1214: 1204: 1198: 1190: 1159: 1155: 1136: 1131: 1120: 1084: 1079: 1067: 1037: 1033: 1014:that binds the 1007: 991:View/Edit Mouse 986:View/Edit Human 949: 944: 941:Location (UCSC) 927: 906: 902: 898: 872: 851: 847: 843: 651: 530: 511:plasma membrane 489: 420: 410: 409: 382: 373: 368: 364: 360: 356: 352: 348: 344: 340: 336: 322: 311: 306: 302: 298: 294: 290: 286: 284:caudate nucleus 282: 278: 274: 260: 204: 191: 183: 173: 172: 171: 164: 144: 121:Gene location ( 72: 59: 52: 28: 23: 22: 15: 12: 11: 5: 15094: 15084: 15083: 15078: 15073: 15056: 15055: 15053: 15052: 15047: 15042: 15037: 15032: 15027: 15022: 15017: 15012: 15007: 15002: 14997: 14991: 14989: 14983: 14982: 14979: 14978: 14976: 14975: 14968: 14961: 14954: 14949: 14946:Matchstick Men 14942: 14935: 14927: 14925: 14921: 14920: 14917: 14916: 14914: 14913: 14906: 14898: 14896: 14892: 14891: 14889: 14888: 14881: 14874: 14871:Matchstick Men 14866: 14864: 14857: 14850: 14846: 14845: 14842: 14841: 14839: 14838: 14833: 14828: 14818: 14812: 14810: 14806: 14805: 14803: 14802: 14797: 14791: 14789: 14785: 14784: 14781: 14780: 14778: 14777: 14771: 14769: 14763: 14762: 14760: 14759: 14753: 14751: 14745: 14744: 14742: 14741: 14735: 14733: 14727: 14726: 14724: 14723: 14718: 14713: 14708: 14703: 14698: 14693: 14687: 14685: 14676: 14667: 14663: 14662: 14660: 14659: 14653: 14648: 14643: 14634: 14624: 14618: 14613: 14604: 14598: 14593: 14588: 14583: 14578: 14573: 14563: 14561: 14557: 14556: 14553: 14552: 14550: 14549: 14544: 14540: 14536: 14532: 14528: 14524: 14520: 14515: 14511: 14507: 14503: 14499: 14494: 14489: 14487: 14483: 14482: 14480: 14479: 14474: 14469: 14464: 14453: 14451: 14444: 14438: 14437: 14435: 14434: 14429: 14423: 14421: 14417: 14416: 14409: 14408: 14401: 14394: 14386: 14377: 14376: 14374: 14373: 14364: 14355: 14342: 14333: 14324: 14315: 14302: 14299: 14298: 14295: 14294: 14291: 14290: 14288: 14287: 14277: 14259: 14256: 14255: 14253: 14252: 14247: 14228:chlorpromazine 14224:acetophenazine 14217: 14199: 14177: 14172: 14167: 14162: 14157: 14152: 14147: 14142: 14137: 14132: 14127: 14122: 14117: 14112: 14107: 14102: 14048: 14043: 14038: 14033: 13971: 13968: 13967: 13965: 13964: 13942: 13932: 13927: 13922: 13917: 13912: 13907: 13902: 13892: 13887: 13882: 13877: 13868: 13862: 13858: 13853: 13852: 13849: 13848: 13846: 13845: 13835: 13809: 13806: 13805: 13803: 13802: 13795:chlorpromazine 13788: 13766: 13752: 13747: 13742: 13737: 13732: 13727: 13722: 13717: 13712: 13707: 13702: 13697: 13692: 13687: 13682: 13677: 13672: 13667: 13662: 13657: 13652: 13647: 13642: 13637: 13632: 13627: 13622: 13584: 13575: 13572: 13571: 13569: 13568: 13563: 13558: 13500: 13495: 13490: 13448: 13442: 13438: 13433: 13432: 13429: 13428: 13426: 13425: 13415: 13397: 13396: 13391: 13386: 13381: 13376: 13367: 13364: 13363: 13361: 13360: 13358:Valerenic acid 13355: 13345: 13340: 13318: 13312: 13308: 13303: 13302: 13299: 13298: 13296: 13295: 13290: 13285: 13280: 13275: 13270: 13265: 13260: 13251: 13248: 13247: 13245: 13244: 13239: 13234: 13229: 13224: 13219: 13214: 13209: 13204: 13199: 13194: 13189: 13184: 13182:Metoclopramide 13179: 13174: 13169: 13164: 13159: 13154: 13149: 13140: 13134: 13130: 13125: 13124: 13121: 13120: 13118: 13117: 13107: 13098: 13095: 13094: 13092: 13091: 13086: 13081: 13076: 13058: 13048: 13043: 13038: 13033: 13015: 13010: 13005: 13000: 12995: 12990: 12985: 12980: 12975: 12970: 12965: 12960: 12955: 12950: 12945: 12940: 12935: 12930: 12925: 12920: 12902: 12897: 12892: 12887: 12878: 12875: 12874: 12872: 12871: 12866: 12844: 12826: 12821: 12816: 12811: 12806: 12788: 12783: 12778: 12756: 12750: 12746: 12738: 12732: 12728: 12723: 12722: 12719: 12718: 12715: 12714: 12712: 12711: 12697: 12688: 12685: 12684: 12682: 12681: 12676: 12657:chlorpromazine 12650: 12636: 12631: 12626: 12621: 12591: 12586: 12581: 12576: 12571: 12566: 12561: 12556: 12551: 12546: 12541: 12536: 12531: 12526: 12521: 12516: 12511: 12506: 12501: 12496: 12491: 12486: 12481: 12476: 12471: 12433: 12428: 12423: 12418: 12413: 12411:Cyproheptadine 12408: 12403: 12398: 12393: 12335: 12330: 12321: 12318: 12317: 12315: 12314: 12309: 12304: 12299: 12294: 12248: 12243: 12238: 12233: 12228: 12223: 12197: 12183: 12178: 12173: 12168: 12163: 12158: 12136: 12131: 12126: 12068: 12046: 12041: 12036: 12031: 12026: 12021: 11987: 11961: 11927: 11921: 11917: 11912: 11911: 11908: 11907: 11905: 11904: 11890: 11887: 11886: 11884: 11883: 11878: 11873: 11870:chlorpromazine 11863: 11858: 11840: 11835: 11830: 11825: 11820: 11815: 11810: 11805: 11800: 11795: 11790: 11785: 11780: 11775: 11770: 11765: 11760: 11755: 11750: 11745: 11740: 11735: 11705: 11700: 11698:Cyproheptadine 11695: 11637: 11628: 11625: 11624: 11622: 11621: 11567: 11562: 11557: 11552: 11542: 11520: 11515: 11481: 11459: 11454: 11424: 11419: 11410: 11404: 11400: 11395: 11394: 11391: 11390: 11388: 11387: 11369: 11366: 11365: 11363: 11362: 11357: 11352: 11347: 11292:chlorpromazine 11285: 11275: 11245: 11240: 11235: 11230: 11225: 11191: 11186: 11181: 11176: 11171: 11166: 11161: 11156: 11151: 11146: 11141: 11136: 11131: 11126: 11121: 11116: 11111: 11106: 11101: 11096: 11091: 11086: 11081: 11076: 11071: 11066: 11061: 11056: 11022: 11017: 11012: 11007: 11002: 10997: 10992: 10890: 10885: 10870:cyproheptadine 10866:Antihistamines 10863: 10858: 10853: 10848: 10843: 10834: 10831: 10830: 10828: 10827: 10781: 10776: 10771: 10766: 10748: 10734: 10732:SCHEMBL5334361 10729: 10724: 10719: 10714: 10709: 10704: 10699: 10677: 10672: 10667: 10662: 10657: 10587: 10582: 10560: 10555: 10550: 10545: 10540: 10535: 10501: 10475: 10470: 10465: 10435: 10388: 10382: 10378: 10370: 10366: 10361: 10360: 10357: 10356: 10353: 10352: 10350: 10349: 10344: 10335: 10332: 10331: 10329: 10328: 10318: 10300: 10295: 10290: 10285: 10264: 10259: 10250: 10244: 10240: 10235: 10234: 10231: 10230: 10228: 10227: 10206: 10203: 10202: 10200: 10199: 10190: 10187: 10186: 10184: 10183: 10173: 10163: 10158: 10148: 10139: 10133: 10129: 10124: 10123: 10120: 10119: 10117: 10116: 10098: 10089: 10086: 10085: 10083: 10082: 10077: 10072: 10067: 10062: 10057: 10052: 10047: 10042: 10037: 10032: 10027: 10022: 10012: 10007: 10002: 9993: 9990: 9989: 9987: 9986: 9956: 9914: 9909: 9904: 9899: 9894: 9889: 9884: 9879: 9874: 9844: 9839: 9834: 9825: 9819: 9815: 9810: 9809: 9806: 9805: 9803: 9802: 9780: 9777: 9776: 9774: 9773: 9768: 9763: 9758: 9753: 9748: 9743: 9738: 9733: 9723: 9718: 9684: 9675: 9672: 9671: 9669: 9668: 9663: 9641: 9636: 9610: 9605: 9600: 9595: 9565: 9560: 9555: 9550: 9545: 9540: 9535: 9526: 9520: 9516: 9511: 9510: 9507: 9506: 9504: 9503: 9493: 9488: 9479: 9476: 9475: 9473: 9472: 9467: 9462: 9457: 9452: 9447: 9442: 9437: 9432: 9427: 9422: 9417: 9412: 9407: 9402: 9397: 9392: 9387: 9382: 9377: 9372: 9367: 9357: 9352: 9347: 9342: 9292: 9287: 9265: 9262: 9261: 9259: 9258: 9253: 9248: 9243: 9238: 9233: 9228: 9186: 9181: 9176: 9171: 9166: 9161: 9156: 9151: 9146: 9141: 9136: 9131: 9126: 9121: 9116: 9111: 9106: 9101: 9096: 9091: 9086: 9081: 9076: 9071: 9066: 9061: 9056: 9051: 9046: 9041: 9036: 9031: 9026: 8984: 8979: 8974: 8969: 8964: 8959: 8954: 8949: 8944: 8939: 8913: 8875: 8841: 8836: 8831: 8822: 8816: 8812: 8804: 8800: 8795: 8794: 8784: 8783: 8776: 8769: 8761: 8752: 8751: 8749: 8748: 8743: 8738: 8733: 8728: 8727: 8726: 8716: 8711: 8710: 8709: 8704: 8696: 8690: 8688: 8687:Other concepts 8684: 8683: 8681: 8680: 8675: 8666: 8660: 8658: 8654: 8653: 8650: 8649: 8647: 8646: 8641: 8636: 8631: 8625: 8623: 8617: 8616: 8613: 8612: 8610: 8609: 8604: 8598: 8596: 8592: 8591: 8589: 8588: 8583: 8578: 8572: 8566: 8560: 8559: 8557: 8556: 8551: 8546: 8540: 8538: 8532: 8531: 8529: 8528: 8523: 8521:Growth factors 8518: 8513: 8500: 8494: 8492: 8483: 8479: 8478: 8476: 8475: 8470: 8465: 8460: 8455: 8450: 8445: 8440: 8439: 8438: 8433: 8423: 8418: 8416: 8410: 8408: 8404: 8403: 8396:Cell signaling 8392: 8391: 8384: 8377: 8369: 8360: 8359: 8356: 8355: 8352: 8351: 8349: 8348: 8342: 8340: 8336: 8335: 8333: 8332: 8326: 8321: 8316: 8311: 8306: 8301: 8296: 8291: 8286: 8276: 8274: 8266: 8265: 8248: 8247: 8244: 8243: 8240: 8239: 8237: 8236: 8230: 8225: 8220: 8211: 8205: 8200: 8191: 8186: 8180: 8175: 8170: 8165: 8160: 8155: 8150: 8137: 8131: 8123: 8119: 8113: 8111: 8105: 8104: 8102: 8101: 8095: 8094: 8093: 8088: 8083: 8072: 8070: 8059: 8058: 8035: 8034: 8031: 8030: 8027: 8026: 8024: 8023: 8017: 8008: 8003: 7997: 7988: 7983: 7978: 7973: 7968: 7962: 7957: 7952: 7943: 7937: 7928: 7923: 7917: 7915: 7909: 7908: 7906: 7905: 7899: 7894: 7889: 7884: 7879: 7874: 7869: 7864: 7859: 7854: 7849: 7844: 7839: 7834: 7829: 7824: 7819: 7814: 7809: 7804: 7794: 7792: 7786: 7785: 7783: 7782: 7781: 7780: 7775: 7774: 7773: 7768: 7763: 7748: 7747: 7746: 7741: 7736: 7731: 7726: 7721: 7716: 7706: 7705: 7704: 7699: 7698: 7697: 7692: 7687: 7672: 7671: 7670: 7669: 7668: 7663: 7658: 7643: 7642: 7641: 7640: 7639: 7634: 7629: 7613: 7611: 7601: 7600: 7583: 7582: 7579: 7578: 7575: 7574: 7571: 7570: 7568: 7567: 7561: 7556: 7547: 7541: 7536: 7531: 7522: 7516: 7511: 7506: 7501: 7496: 7491: 7486: 7477: 7472: 7470:Adrenomedullin 7466: 7464: 7458: 7457: 7455: 7454: 7448: 7443: 7438: 7433: 7428: 7423: 7418: 7413: 7408: 7403: 7398: 7393: 7388: 7383: 7378: 7373: 7368: 7363: 7358: 7353: 7348: 7343: 7338: 7333: 7328: 7323: 7318: 7313: 7308: 7303: 7298: 7293: 7288: 7283: 7278: 7273: 7268: 7263: 7258: 7253: 7248: 7243: 7238: 7233: 7228: 7223: 7218: 7213: 7208: 7203: 7198: 7193: 7188: 7183: 7178: 7173: 7168: 7163: 7158: 7153: 7148: 7143: 7138: 7133: 7128: 7123: 7118: 7113: 7108: 7103: 7098: 7093: 7083: 7081: 7075: 7074: 7072: 7071: 7065: 7064: 7063: 7058: 7053: 7048: 7043: 7038: 7033: 7028: 7023: 7018: 7013: 7008: 7003: 6998: 6993: 6988: 6983: 6978: 6973: 6968: 6963: 6958: 6953: 6948: 6943: 6932: 6930: 6920: 6916: 6915: 6912: 6911: 6909: 6908: 6902: 6897: 6888: 6883: 6878: 6873: 6867: 6862: 6853: 6847: 6842: 6837: 6832: 6823: 6817: 6812: 6807: 6798: 6793: 6787: 6778: 6773: 6767: 6758: 6744: 6739: 6734: 6725: 6720: 6714: 6705: 6699: 6694: 6689: 6684: 6675: 6669: 6664: 6659: 6654: 6649: 6644: 6639: 6634: 6629: 6620: 6615: 6610: 6605: 6599: 6590: 6584: 6579: 6570: 6565: 6559: 6554: 6548:Formyl peptide 6545: 6544: 6543: 6538: 6528: 6522: 6513: 6508: 6507: 6506: 6500: 6491: 6485: 6480: 6470: 6465: 6459: 6450: 6444: 6438: 6428: 6426: 6422: 6421: 6419: 6418: 6412: 6403: 6397: 6388: 6379: 6373: 6368: 6363: 6354: 6349: 6343: 6334: 6328: 6318: 6316: 6307: 6303: 6302: 6299: 6298: 6296: 6295: 6290: 6284: 6279: 6274: 6269: 6260: 6255: 6250: 6244: 6239: 6234: 6229: 6224: 6219: 6214: 6205: 6199: 6194: 6189: 6184: 6179: 6170: 6169: 6168: 6163: 6158: 6148: 6142: 6137: 6132: 6123: 6118: 6113: 6107: 6102: 6089: 6080: 6074: 6072: 6068: 6067: 6065: 6064: 6059: 6054: 6053: 6052: 6043: 6038: 6033: 6020: 6006: 6001: 5996: 5995: 5994: 5989: 5979: 5973: 5963: 5961: 5952: 5946: 5945: 5942: 5941: 5939: 5938: 5932: 5927: 5922: 5917: 5912: 5903: 5897: 5892: 5883: 5882: 5881: 5876: 5871: 5866: 5856: 5851: 5850: 5849: 5844: 5839: 5834: 5829: 5819: 5813: 5808: 5803: 5798: 5788: 5786: 5782: 5781: 5779: 5778: 5772: 5767: 5762: 5753: 5747: 5742: 5733: 5727: 5722: 5717: 5712: 5695: 5693: 5687: 5686: 5684: 5683: 5677: 5672: 5667: 5662: 5657: 5652: 5647: 5642: 5637: 5632: 5627: 5618: 5612: 5607: 5602: 5592: 5590: 5584: 5583: 5581: 5580: 5575: 5570: 5565: 5559: 5554: 5545: 5539: 5534: 5524: 5522: 5513: 5503: 5502: 5485: 5484: 5473: 5472: 5465: 5458: 5450: 5427: 5426: 5391: 5373:(6): 621–627. 5362: 5336:(3): 231–238. 5325: 5307:(2): 126–130. 5295: 5275:(1–2): 63–68. 5260: 5234:(4): 387–390. 5223: 5178: 5160:(3): 551–561. 5149: 5131:(3): 339–348. 5119: 5074: 5056:(2): 274–279. 5041: 5012: 4994:(9): 681–684. 4983: 4965:(5): 441–460. 4954: 4917: 4888: 4859: 4833:(4): 533–554. 4822: 4776: 4774: 4771: 4770: 4769: 4748: 4727: 4726:External links 4724: 4722: 4721: 4670: 4627: 4606:(3): 349–356. 4586: 4559:(3): 169–172. 4540: 4521:(3): 105–110. 4505: 4464: 4415: 4371: 4350:(2): 164–169. 4330: 4309:(4): 467–470. 4289: 4249: 4205: 4157: 4114: 4062: 4018: 3952: 3931:(1–2): 63–68. 3911: 3870: 3828: 3817: 3788:(1): 288–305. 3775: 3764: 3720: 3709: 3682:(3): 765–780. 3665: 3656: 3645: 3610: 3561: 3525: 3474: 3451:10.1038/ng.158 3445:(6): 719–721. 3425: 3368: 3341:(3): 157–161. 3324: 3273: 3262:(4): 266–288. 3246: 3211: 3192:(2): 177–185. 3176: 3127: 3092: 3063:(3): 249–264. 3043: 3023: 3009: 2971: 2909: 2860: 2815: 2794:(5): 478–491. 2771: 2750:(5): 491–496. 2730: 2703:(4): 242–251. 2687: 2658:(2): 453–462. 2638: 2595: 2553: 2542: 2491: 2472:(3): 339–348. 2455: 2441: 2423: 2405: 2383: 2381: 2378: 2377: 2376: 2371: 2366: 2361: 2357: 2350: 2347: 2306: 2303: 2293: 2289: 2286: 2280: 2277: 2272: 2271: 2268: 2265: 2262: 2259: 2250: 2247: 2190: 2187: 2178: 2175: 2162: 2158: 2155: 2154: 2153: 2150: 2142: 2139: 2137: 2136: 2131: 2126: 2121: 2116: 2111: 2106: 2101: 2096: 2091: 2086: 2081: 2076: 2071: 2070: 2069: 2047: 2032:Chlorpromazine 2023:Antipsychotics 2020: 2009:Cyproheptadine 2005:Antihistamines 2002: 2001: 2000: 1982: 1962: 1960: 1957: 1955: 1954: 1949: 1944: 1939: 1934: 1929: 1924: 1919: 1914: 1909: 1904: 1899: 1894: 1889: 1884: 1879: 1874: 1869: 1864: 1859: 1854: 1849: 1844: 1839: 1833: 1831: 1828: 1827: 1826: 1819: 1816: 1814: 1813: 1807: 1802: 1797: 1792: 1787: 1782: 1777: 1772: 1771: 1770: 1748: 1734: 1712: 1697: 1692: 1687: 1682: 1677: 1672: 1667: 1662: 1657: 1652: 1647: 1642: 1637: 1632: 1627: 1622: 1617: 1611: 1606:Main article: 1603: 1600: 1598: 1595: 1578: 1566: 1562: 1559: 1539: 1532: 1528: 1524: 1511: 1492: 1488: 1484: 1456: 1453: 1448: 1444: 1440: 1429: 1425: 1421: 1397: 1386: 1382: 1378: 1374: 1370: 1366: 1354: 1343: 1339: 1335: 1327: 1303: 1299: 1292: 1276: 1264: 1256: 1248: 1244: 1232: 1225:antidepressant 1219: 1212: 1202: 1196: 1188: 1157: 1153: 1147:norepinephrine 1134: 1130: 1127: 1118: 1087:choroid plexus 1082: 1078: 1075: 1066: 1063: 1035: 1031: 1012:5-HT2 receptor 1005: 998: 997: 994: 993: 988: 978: 977: 971: 970: 967: 966: 964: 962: 955: 954: 947: 942: 938: 937: 934: 933: 923: 922: 916: 913: 912: 894: 893: 887: 883: 882: 879: 878: 868: 867: 861: 858: 857: 839: 838: 832: 828: 827: 824: 823: 815: 814: 808: 805: 804: 796: 795: 789: 783: 782: 779: 778: 770: 769: 763: 760: 759: 753: 752: 746: 740: 739: 736: 735: 727: 726: 720: 717: 716: 708: 707: 701: 695: 694: 689: 684: 680: 679: 669: 668: 665: 664: 653: 652: 650: 649: 644: 639: 634: 629: 624: 619: 614: 609: 604: 599: 594: 589: 584: 579: 574: 569: 564: 559: 554: 549: 544: 538: 536: 532: 531: 529: 528: 523: 518: 513: 508: 503: 497: 495: 491: 490: 488: 487: 482: 477: 472: 467: 462: 457: 451: 449: 445: 444: 434: 433: 430: 429: 426: 425: 417: 416: 398: 392: 391: 388: 387: 379: 378: 375: 374: 372: 371: 367: 363: 359: 355: 351: 347: 343: 339: 335: 331: 328: 327: 316: 313: 312: 310: 309: 305: 301: 297: 293: 289: 285: 281: 277: 273: 269: 266: 265: 253: 252: 244: 233: 227: 226: 223:RNA expression 215: 214: 211: 210: 202: 198: 197: 189: 186: 181: 175: 174: 165: 158: 152: 148: 147: 142: 136: 135: 127: 126: 114: 113: 70: 66: 65: 57: 49: 48: 44: 43: 35: 34: 26: 9: 6: 4: 3: 2: 15093: 15082: 15079: 15077: 15074: 15072: 15069: 15068: 15066: 15051: 15048: 15046: 15043: 15041: 15038: 15036: 15033: 15031: 15028: 15026: 15023: 15021: 15018: 15016: 15013: 15011: 15008: 15006: 15003: 15001: 14998: 14996: 14993: 14992: 14990: 14988: 14984: 14974: 14973: 14969: 14966: 14962: 14960: 14959: 14955: 14953: 14950: 14948: 14947: 14943: 14941: 14940: 14936: 14934: 14933: 14929: 14928: 14926: 14922: 14912: 14911: 14910:Just Checking 14907: 14905: 14904: 14900: 14899: 14897: 14893: 14887: 14886: 14882: 14880: 14879: 14875: 14873: 14872: 14868: 14867: 14865: 14861: 14858: 14854: 14851: 14847: 14837: 14834: 14832: 14829: 14826: 14822: 14819: 14817: 14814: 14813: 14811: 14807: 14801: 14798: 14796: 14793: 14792: 14790: 14786: 14776: 14773: 14772: 14770: 14768: 14764: 14758: 14755: 14754: 14752: 14750: 14746: 14740: 14737: 14736: 14734: 14732: 14728: 14722: 14719: 14717: 14714: 14712: 14709: 14707: 14704: 14702: 14699: 14697: 14694: 14692: 14689: 14688: 14686: 14684: 14680: 14677: 14675: 14674:Serotonergics 14671: 14668: 14664: 14657: 14654: 14652: 14649: 14647: 14644: 14642: 14638: 14635: 14632: 14628: 14625: 14622: 14619: 14617: 14614: 14612: 14608: 14605: 14602: 14599: 14597: 14594: 14592: 14589: 14587: 14584: 14582: 14579: 14577: 14574: 14572: 14568: 14565: 14564: 14562: 14558: 14548: 14545: 14543: 14537: 14535: 14529: 14527: 14521: 14519: 14516: 14514: 14508: 14506: 14500: 14498: 14491: 14490: 14488: 14484: 14478: 14475: 14473: 14470: 14468: 14465: 14462: 14458: 14457:Basal ganglia 14455: 14454: 14452: 14448: 14445: 14443: 14439: 14433: 14430: 14428: 14425: 14424: 14422: 14418: 14414: 14407: 14402: 14400: 14395: 14393: 14388: 14387: 14384: 14371: 14370: 14365: 14362: 14361: 14356: 14353: 14352: 14348: 14343: 14340: 14339: 14338:Melatonergics 14334: 14331: 14330: 14329:Dopaminergics 14325: 14322: 14321: 14316: 14313: 14312: 14309: 14304: 14303: 14300: 14285: 14281: 14278: 14275: 14271: 14267: 14264: 14261: 14260: 14257: 14251: 14248: 14245: 14241: 14237: 14233: 14229: 14225: 14221: 14218: 14215: 14211: 14207: 14206:amitriptyline 14203: 14200: 14197: 14193: 14189: 14185: 14181: 14178: 14176: 14173: 14171: 14168: 14166: 14163: 14161: 14158: 14156: 14153: 14151: 14148: 14146: 14143: 14141: 14138: 14136: 14133: 14131: 14128: 14126: 14123: 14121: 14118: 14116: 14113: 14111: 14108: 14106: 14103: 14100: 14096: 14092: 14088: 14084: 14080: 14076: 14072: 14068: 14064: 14063:bromocriptine 14060: 14056: 14052: 14049: 14047: 14044: 14042: 14039: 14037: 14034: 14031: 14027: 14023: 14019: 14015: 14011: 14007: 14003: 13999: 13995: 13994:brexpiprazole 13991: 13987: 13983: 13979: 13976: 13973: 13972: 13969: 13962: 13958: 13954: 13950: 13946: 13943: 13940: 13936: 13933: 13931: 13928: 13926: 13923: 13921: 13918: 13916: 13913: 13911: 13908: 13906: 13903: 13900: 13896: 13893: 13891: 13888: 13886: 13883: 13881: 13878: 13876: 13873: 13870: 13869: 13866: 13863: 13861: 13854: 13843: 13839: 13836: 13833: 13829: 13825: 13824:bromocriptine 13821: 13817: 13814: 13811: 13810: 13807: 13800: 13796: 13792: 13789: 13786: 13785:nortriptyline 13782: 13778: 13774: 13773:amitriptyline 13770: 13767: 13764: 13760: 13756: 13753: 13751: 13748: 13746: 13743: 13741: 13738: 13736: 13733: 13731: 13728: 13726: 13723: 13721: 13718: 13716: 13713: 13711: 13708: 13706: 13703: 13701: 13698: 13696: 13693: 13691: 13688: 13686: 13683: 13681: 13678: 13676: 13673: 13671: 13668: 13666: 13663: 13661: 13658: 13656: 13653: 13651: 13648: 13646: 13643: 13641: 13638: 13636: 13633: 13631: 13628: 13626: 13623: 13620: 13616: 13612: 13608: 13604: 13600: 13596: 13592: 13588: 13585: 13583: 13580: 13577: 13576: 13573: 13567: 13564: 13562: 13559: 13556: 13552: 13548: 13544: 13540: 13536: 13532: 13528: 13524: 13520: 13516: 13512: 13508: 13504: 13501: 13499: 13496: 13494: 13491: 13488: 13484: 13480: 13476: 13472: 13468: 13464: 13460: 13456: 13453: 13450: 13449: 13446: 13443: 13441: 13434: 13423: 13419: 13416: 13413: 13409: 13405: 13402: 13399: 13398: 13395: 13392: 13390: 13387: 13385: 13382: 13380: 13377: 13375: 13372: 13369: 13368: 13365: 13359: 13356: 13353: 13349: 13346: 13344: 13341: 13338: 13334: 13330: 13326: 13323: 13320: 13319: 13316: 13313: 13311: 13304: 13294: 13291: 13289: 13286: 13284: 13281: 13279: 13276: 13274: 13271: 13269: 13266: 13264: 13261: 13259: 13256: 13253: 13252: 13249: 13243: 13240: 13238: 13235: 13233: 13230: 13228: 13225: 13223: 13220: 13218: 13215: 13213: 13210: 13208: 13205: 13203: 13200: 13198: 13195: 13193: 13190: 13188: 13185: 13183: 13180: 13178: 13175: 13173: 13170: 13168: 13165: 13163: 13160: 13158: 13155: 13153: 13150: 13148: 13145: 13142: 13141: 13138: 13135: 13133: 13126: 13115: 13111: 13108: 13106: 13103: 13100: 13099: 13096: 13090: 13087: 13085: 13082: 13080: 13077: 13074: 13070: 13066: 13065:nitrous oxide 13062: 13059: 13056: 13052: 13049: 13047: 13044: 13042: 13039: 13037: 13034: 13031: 13027: 13023: 13019: 13016: 13014: 13013:Tedatioxetine 13011: 13009: 13006: 13004: 13001: 12999: 12996: 12994: 12991: 12989: 12986: 12984: 12981: 12979: 12976: 12974: 12971: 12969: 12966: 12964: 12963:Galanolactone 12961: 12959: 12956: 12954: 12951: 12949: 12946: 12944: 12941: 12939: 12936: 12934: 12931: 12929: 12926: 12924: 12921: 12918: 12914: 12910: 12906: 12903: 12901: 12898: 12896: 12893: 12891: 12888: 12886: 12883: 12880: 12879: 12876: 12870: 12867: 12864: 12860: 12856: 12852: 12848: 12845: 12842: 12838: 12834: 12830: 12827: 12825: 12822: 12820: 12817: 12815: 12812: 12810: 12807: 12804: 12800: 12796: 12792: 12789: 12787: 12784: 12782: 12779: 12776: 12772: 12768: 12764: 12761: 12758: 12757: 12754: 12751: 12749: 12742: 12739: 12736: 12731: 12724: 12709: 12705: 12701: 12698: 12696: 12693: 12690: 12689: 12686: 12680: 12677: 12674: 12670: 12666: 12662: 12658: 12654: 12651: 12648: 12647:nortriptyline 12644: 12643:amitriptyline 12640: 12637: 12635: 12632: 12630: 12627: 12625: 12622: 12619: 12615: 12611: 12607: 12606:esmirtazapine 12603: 12599: 12595: 12592: 12590: 12589:Tedatioxetine 12587: 12585: 12582: 12580: 12577: 12575: 12572: 12570: 12567: 12565: 12562: 12560: 12557: 12555: 12552: 12550: 12547: 12545: 12542: 12540: 12537: 12535: 12532: 12530: 12527: 12525: 12522: 12520: 12517: 12515: 12512: 12510: 12507: 12505: 12502: 12500: 12497: 12495: 12492: 12490: 12487: 12485: 12482: 12480: 12477: 12475: 12472: 12469: 12465: 12461: 12457: 12453: 12449: 12445: 12444:bromocriptine 12441: 12437: 12434: 12432: 12429: 12427: 12424: 12422: 12421:Desmetramadol 12419: 12417: 12414: 12412: 12409: 12407: 12404: 12402: 12399: 12397: 12394: 12391: 12387: 12383: 12379: 12375: 12371: 12367: 12363: 12359: 12355: 12351: 12347: 12343: 12339: 12336: 12334: 12331: 12329: 12326: 12323: 12322: 12319: 12313: 12310: 12308: 12305: 12303: 12300: 12298: 12295: 12292: 12288: 12284: 12280: 12276: 12272: 12268: 12264: 12260: 12256: 12252: 12249: 12247: 12244: 12242: 12239: 12237: 12234: 12232: 12229: 12227: 12224: 12221: 12217: 12213: 12209: 12205: 12201: 12198: 12195: 12191: 12187: 12184: 12182: 12179: 12177: 12174: 12172: 12169: 12167: 12164: 12162: 12159: 12156: 12152: 12148: 12144: 12140: 12137: 12135: 12132: 12130: 12127: 12124: 12120: 12116: 12112: 12108: 12104: 12100: 12096: 12092: 12088: 12084: 12080: 12076: 12072: 12069: 12066: 12062: 12058: 12054: 12050: 12047: 12045: 12042: 12040: 12037: 12035: 12032: 12030: 12027: 12025: 12022: 12019: 12015: 12011: 12007: 12003: 11999: 11995: 11991: 11988: 11985: 11981: 11977: 11973: 11969: 11965: 11962: 11959: 11955: 11951: 11947: 11943: 11939: 11935: 11932: 11929: 11928: 11925: 11922: 11920: 11913: 11902: 11898: 11895: 11892: 11891: 11888: 11882: 11879: 11877: 11874: 11871: 11867: 11864: 11862: 11859: 11856: 11852: 11848: 11844: 11841: 11839: 11836: 11834: 11831: 11829: 11826: 11824: 11821: 11819: 11816: 11814: 11811: 11809: 11806: 11804: 11801: 11799: 11796: 11794: 11791: 11789: 11786: 11784: 11781: 11779: 11776: 11774: 11771: 11769: 11766: 11764: 11761: 11759: 11756: 11754: 11751: 11749: 11746: 11744: 11741: 11739: 11736: 11733: 11729: 11725: 11721: 11717: 11716:bromocriptine 11713: 11709: 11706: 11704: 11701: 11699: 11696: 11693: 11689: 11685: 11681: 11677: 11673: 11669: 11665: 11661: 11657: 11656:brexpiprazole 11653: 11649: 11645: 11641: 11638: 11636: 11633: 11630: 11629: 11626: 11619: 11615: 11611: 11607: 11603: 11599: 11595: 11591: 11587: 11583: 11579: 11575: 11571: 11568: 11566: 11563: 11561: 11558: 11556: 11553: 11550: 11546: 11543: 11540: 11536: 11532: 11528: 11524: 11521: 11519: 11516: 11513: 11509: 11505: 11501: 11497: 11493: 11489: 11485: 11482: 11479: 11475: 11471: 11467: 11463: 11460: 11458: 11455: 11452: 11448: 11444: 11440: 11436: 11432: 11428: 11425: 11423: 11420: 11418: 11415: 11412: 11411: 11408: 11405: 11403: 11396: 11385: 11381: 11377: 11374: 11371: 11370: 11367: 11361: 11358: 11356: 11353: 11351: 11348: 11345: 11341: 11337: 11333: 11329: 11325: 11321: 11317: 11313: 11309: 11305: 11301: 11297: 11293: 11289: 11286: 11283: 11282:amitriptyline 11279: 11276: 11273: 11269: 11265: 11261: 11260:esmirtazapine 11257: 11253: 11249: 11246: 11244: 11241: 11239: 11236: 11234: 11231: 11229: 11226: 11223: 11219: 11218:triazoledione 11215: 11211: 11207: 11203: 11199: 11195: 11192: 11190: 11187: 11185: 11182: 11180: 11177: 11175: 11172: 11170: 11167: 11165: 11162: 11160: 11157: 11155: 11152: 11150: 11147: 11145: 11142: 11140: 11137: 11135: 11132: 11130: 11127: 11125: 11122: 11120: 11119:Naftidrofuryl 11117: 11115: 11112: 11110: 11107: 11105: 11102: 11100: 11097: 11095: 11092: 11090: 11087: 11085: 11082: 11080: 11077: 11075: 11072: 11070: 11067: 11065: 11062: 11060: 11057: 11054: 11050: 11046: 11042: 11038: 11034: 11030: 11026: 11023: 11021: 11018: 11016: 11013: 11011: 11008: 11006: 11003: 11001: 10998: 10996: 10993: 10990: 10986: 10982: 10978: 10974: 10970: 10966: 10962: 10958: 10954: 10950: 10946: 10942: 10938: 10934: 10930: 10926: 10922: 10918: 10914: 10913:brexpiprazole 10910: 10906: 10902: 10898: 10894: 10891: 10889: 10886: 10883: 10879: 10875: 10871: 10867: 10864: 10862: 10859: 10857: 10854: 10852: 10849: 10847: 10844: 10842: 10839: 10836: 10835: 10832: 10825: 10821: 10817: 10813: 10809: 10805: 10801: 10797: 10793: 10789: 10785: 10782: 10780: 10777: 10775: 10772: 10770: 10767: 10764: 10760: 10756: 10752: 10749: 10746: 10742: 10738: 10735: 10733: 10730: 10728: 10725: 10723: 10720: 10718: 10715: 10713: 10710: 10708: 10705: 10703: 10700: 10697: 10693: 10689: 10685: 10681: 10678: 10676: 10673: 10671: 10668: 10666: 10663: 10661: 10658: 10655: 10651: 10647: 10643: 10639: 10635: 10631: 10627: 10623: 10619: 10615: 10611: 10607: 10603: 10602:bromocriptine 10599: 10595: 10591: 10588: 10586: 10583: 10580: 10576: 10572: 10568: 10564: 10561: 10559: 10556: 10554: 10551: 10549: 10546: 10544: 10541: 10539: 10536: 10533: 10529: 10525: 10521: 10517: 10513: 10509: 10505: 10502: 10499: 10495: 10491: 10487: 10483: 10479: 10476: 10474: 10471: 10469: 10466: 10463: 10459: 10455: 10451: 10447: 10443: 10439: 10436: 10433: 10429: 10425: 10421: 10417: 10413: 10409: 10405: 10401: 10397: 10393: 10390: 10389: 10386: 10383: 10381: 10374: 10371: 10369: 10362: 10348: 10345: 10343: 10340: 10337: 10336: 10333: 10326: 10322: 10319: 10316: 10312: 10308: 10304: 10301: 10299: 10296: 10294: 10291: 10289: 10286: 10283: 10280: 10276: 10272: 10271:bromocriptine 10268: 10265: 10263: 10260: 10258: 10255: 10252: 10251: 10248: 10245: 10243: 10236: 10226: 10222: 10218: 10214: 10211: 10208: 10207: 10204: 10198: 10195: 10192: 10191: 10188: 10181: 10177: 10174: 10171: 10167: 10164: 10162: 10159: 10156: 10152: 10149: 10147: 10144: 10141: 10140: 10137: 10134: 10132: 10125: 10114: 10110: 10106: 10102: 10099: 10097: 10094: 10091: 10090: 10087: 10081: 10078: 10076: 10073: 10071: 10068: 10066: 10063: 10061: 10058: 10056: 10053: 10051: 10048: 10046: 10043: 10041: 10038: 10036: 10033: 10031: 10028: 10026: 10023: 10020: 10016: 10013: 10011: 10008: 10006: 10003: 10001: 9998: 9995: 9994: 9991: 9984: 9980: 9976: 9972: 9968: 9964: 9960: 9957: 9954: 9950: 9946: 9942: 9938: 9934: 9930: 9926: 9922: 9918: 9915: 9913: 9910: 9908: 9905: 9903: 9900: 9898: 9895: 9893: 9890: 9888: 9885: 9883: 9880: 9878: 9875: 9872: 9868: 9864: 9860: 9856: 9852: 9851:bromocriptine 9848: 9845: 9843: 9840: 9838: 9835: 9833: 9830: 9827: 9826: 9823: 9820: 9818: 9811: 9800: 9796: 9792: 9788: 9785: 9782: 9781: 9778: 9772: 9769: 9767: 9764: 9762: 9759: 9757: 9754: 9752: 9749: 9747: 9744: 9742: 9739: 9737: 9734: 9731: 9727: 9724: 9722: 9719: 9716: 9712: 9708: 9704: 9700: 9696: 9692: 9688: 9687:Beta blockers 9685: 9683: 9680: 9677: 9676: 9673: 9667: 9664: 9661: 9657: 9653: 9649: 9645: 9642: 9640: 9637: 9634: 9630: 9626: 9622: 9618: 9614: 9611: 9609: 9606: 9604: 9601: 9599: 9596: 9593: 9589: 9585: 9581: 9577: 9573: 9572:bromocriptine 9569: 9566: 9564: 9561: 9559: 9556: 9554: 9551: 9549: 9546: 9544: 9541: 9539: 9536: 9534: 9531: 9528: 9527: 9524: 9521: 9519: 9512: 9501: 9497: 9494: 9492: 9489: 9487: 9484: 9481: 9480: 9477: 9471: 9468: 9466: 9463: 9461: 9458: 9456: 9453: 9451: 9448: 9446: 9443: 9441: 9438: 9436: 9433: 9431: 9428: 9426: 9423: 9421: 9418: 9416: 9413: 9411: 9408: 9406: 9403: 9401: 9398: 9396: 9393: 9391: 9388: 9386: 9383: 9381: 9378: 9376: 9373: 9371: 9368: 9365: 9361: 9358: 9356: 9353: 9351: 9348: 9346: 9343: 9340: 9336: 9332: 9328: 9324: 9320: 9316: 9312: 9308: 9307:cyanopindolol 9304: 9300: 9296: 9295:Beta blockers 9293: 9291: 9288: 9285: 9281: 9277: 9273: 9270: 9267: 9266: 9263: 9257: 9254: 9252: 9249: 9247: 9244: 9242: 9239: 9237: 9234: 9232: 9229: 9226: 9222: 9218: 9214: 9210: 9206: 9202: 9198: 9194: 9190: 9187: 9185: 9182: 9180: 9177: 9175: 9172: 9170: 9167: 9165: 9162: 9160: 9157: 9155: 9152: 9150: 9147: 9145: 9142: 9140: 9137: 9135: 9132: 9130: 9127: 9125: 9122: 9120: 9117: 9115: 9112: 9110: 9107: 9105: 9102: 9100: 9097: 9095: 9092: 9090: 9087: 9085: 9082: 9080: 9077: 9075: 9072: 9070: 9067: 9065: 9062: 9060: 9057: 9055: 9052: 9050: 9047: 9045: 9042: 9040: 9037: 9035: 9032: 9030: 9027: 9024: 9020: 9016: 9012: 9008: 9004: 9000: 8996: 8992: 8991:bromocriptine 8988: 8985: 8983: 8980: 8978: 8975: 8973: 8970: 8968: 8965: 8963: 8960: 8958: 8955: 8953: 8950: 8948: 8945: 8943: 8940: 8937: 8933: 8929: 8925: 8921: 8917: 8914: 8911: 8907: 8903: 8899: 8895: 8891: 8890:brexpiprazole 8887: 8883: 8879: 8876: 8873: 8869: 8865: 8864:triazoledione 8861: 8857: 8853: 8849: 8845: 8842: 8840: 8837: 8835: 8832: 8830: 8827: 8824: 8823: 8820: 8817: 8815: 8808: 8805: 8803: 8796: 8792: 8789: 8782: 8777: 8775: 8770: 8768: 8763: 8762: 8759: 8747: 8744: 8742: 8739: 8737: 8734: 8732: 8729: 8725: 8722: 8721: 8720: 8717: 8715: 8712: 8708: 8705: 8703: 8700: 8699: 8697: 8695: 8692: 8691: 8689: 8685: 8679: 8676: 8674: 8670: 8667: 8665: 8662: 8661: 8659: 8655: 8645: 8642: 8640: 8637: 8635: 8632: 8630: 8627: 8626: 8624: 8622: 8618: 8608: 8605: 8603: 8600: 8599: 8597: 8593: 8587: 8584: 8582: 8579: 8577: 8574: 8573: 8570: 8567: 8565: 8561: 8555: 8552: 8550: 8549:Intracellular 8547: 8545: 8542: 8541: 8539: 8537: 8533: 8527: 8524: 8522: 8519: 8517: 8514: 8512: 8511:Neurohormones 8508: 8507:Neuropeptides 8504: 8501: 8499: 8496: 8495: 8493: 8491: 8487: 8484: 8480: 8474: 8471: 8469: 8466: 8464: 8461: 8459: 8458:Fas apoptosis 8456: 8454: 8451: 8449: 8446: 8444: 8441: 8437: 8434: 8432: 8429: 8428: 8427: 8424: 8422: 8419: 8417: 8415: 8412: 8411: 8409: 8405: 8401: 8397: 8390: 8385: 8383: 8378: 8376: 8371: 8370: 8367: 8347: 8344: 8343: 8341: 8337: 8330: 8327: 8325: 8322: 8320: 8317: 8315: 8312: 8310: 8307: 8305: 8302: 8300: 8297: 8295: 8292: 8290: 8287: 8285: 8281: 8278: 8277: 8275: 8271: 8267: 8263: 8259: 8253: 8249: 8234: 8231: 8229: 8226: 8224: 8221: 8219: 8215: 8212: 8209: 8206: 8204: 8201: 8199: 8195: 8192: 8190: 8187: 8184: 8181: 8179: 8176: 8174: 8171: 8169: 8166: 8164: 8161: 8159: 8156: 8154: 8151: 8149: 8145: 8141: 8138: 8135: 8132: 8130: 8126: 8120: 8118: 8115: 8114: 8112: 8110: 8106: 8099: 8096: 8092: 8089: 8087: 8084: 8082: 8079: 8078: 8077: 8074: 8073: 8071: 8068: 8064: 8060: 8056: 8052: 8049: 8045: 8040: 8036: 8021: 8018: 8016: 8012: 8009: 8007: 8004: 8001: 7998: 7996: 7992: 7989: 7987: 7984: 7982: 7979: 7977: 7974: 7972: 7969: 7966: 7963: 7961: 7958: 7956: 7953: 7951: 7947: 7944: 7941: 7938: 7936: 7932: 7929: 7927: 7924: 7922: 7919: 7918: 7916: 7914: 7910: 7903: 7900: 7898: 7895: 7893: 7890: 7888: 7885: 7883: 7880: 7878: 7875: 7873: 7870: 7868: 7865: 7863: 7860: 7858: 7855: 7853: 7850: 7848: 7845: 7843: 7840: 7838: 7835: 7833: 7830: 7828: 7825: 7823: 7820: 7818: 7815: 7813: 7810: 7808: 7805: 7803: 7799: 7796: 7795: 7793: 7791: 7787: 7779: 7776: 7772: 7769: 7767: 7764: 7762: 7759: 7758: 7757: 7754: 7753: 7752: 7749: 7745: 7742: 7740: 7737: 7735: 7732: 7730: 7727: 7725: 7722: 7720: 7717: 7715: 7712: 7711: 7710: 7707: 7703: 7700: 7696: 7693: 7691: 7688: 7686: 7683: 7682: 7681: 7678: 7677: 7676: 7673: 7667: 7664: 7662: 7659: 7657: 7654: 7653: 7652: 7649: 7648: 7647: 7644: 7638: 7635: 7633: 7630: 7628: 7625: 7624: 7623: 7620: 7619: 7618: 7615: 7614: 7612: 7610: 7606: 7602: 7597: 7593: 7588: 7584: 7565: 7562: 7560: 7557: 7555: 7551: 7548: 7545: 7542: 7540: 7537: 7535: 7532: 7530: 7526: 7523: 7520: 7517: 7515: 7512: 7510: 7507: 7505: 7502: 7500: 7497: 7495: 7492: 7490: 7487: 7485: 7481: 7478: 7476: 7473: 7471: 7468: 7467: 7465: 7463: 7459: 7452: 7449: 7447: 7444: 7442: 7439: 7437: 7434: 7432: 7429: 7427: 7424: 7422: 7419: 7417: 7414: 7412: 7409: 7407: 7404: 7402: 7399: 7397: 7394: 7392: 7389: 7387: 7384: 7382: 7379: 7377: 7374: 7372: 7369: 7367: 7364: 7362: 7359: 7357: 7354: 7352: 7349: 7347: 7344: 7342: 7339: 7337: 7334: 7332: 7329: 7327: 7324: 7322: 7319: 7317: 7314: 7312: 7309: 7307: 7304: 7302: 7299: 7297: 7294: 7292: 7289: 7287: 7284: 7282: 7279: 7277: 7274: 7272: 7269: 7267: 7264: 7262: 7259: 7257: 7254: 7252: 7249: 7247: 7244: 7242: 7239: 7237: 7234: 7232: 7229: 7227: 7224: 7222: 7219: 7217: 7214: 7212: 7209: 7207: 7204: 7202: 7199: 7197: 7194: 7192: 7189: 7187: 7184: 7182: 7179: 7177: 7174: 7172: 7169: 7167: 7164: 7162: 7159: 7157: 7154: 7152: 7149: 7147: 7144: 7142: 7139: 7137: 7134: 7132: 7129: 7127: 7124: 7122: 7119: 7117: 7114: 7112: 7109: 7107: 7104: 7102: 7099: 7097: 7094: 7092: 7088: 7085: 7084: 7082: 7080: 7076: 7069: 7066: 7062: 7059: 7057: 7054: 7052: 7049: 7047: 7044: 7042: 7039: 7037: 7034: 7032: 7029: 7027: 7024: 7022: 7019: 7017: 7014: 7012: 7009: 7007: 7004: 7002: 6999: 6997: 6994: 6992: 6989: 6987: 6984: 6982: 6979: 6977: 6974: 6972: 6969: 6967: 6964: 6962: 6959: 6957: 6954: 6952: 6949: 6947: 6944: 6942: 6939: 6938: 6937: 6934: 6933: 6931: 6928: 6924: 6921: 6919:Miscellaneous 6917: 6906: 6903: 6901: 6898: 6896: 6892: 6889: 6887: 6884: 6882: 6879: 6877: 6874: 6871: 6868: 6866: 6863: 6861: 6857: 6854: 6851: 6848: 6846: 6843: 6841: 6838: 6836: 6833: 6831: 6827: 6824: 6821: 6818: 6816: 6813: 6811: 6808: 6806: 6802: 6799: 6797: 6794: 6791: 6788: 6786: 6782: 6779: 6777: 6774: 6771: 6768: 6766: 6762: 6759: 6756: 6752: 6748: 6745: 6743: 6740: 6738: 6735: 6733: 6729: 6726: 6724: 6721: 6718: 6715: 6713: 6709: 6706: 6703: 6700: 6698: 6695: 6693: 6690: 6688: 6685: 6683: 6679: 6676: 6673: 6670: 6668: 6665: 6663: 6660: 6658: 6655: 6653: 6650: 6648: 6645: 6643: 6640: 6638: 6635: 6633: 6630: 6628: 6624: 6621: 6619: 6616: 6614: 6611: 6609: 6606: 6603: 6600: 6598: 6594: 6591: 6588: 6585: 6583: 6580: 6578: 6574: 6571: 6569: 6566: 6563: 6560: 6558: 6555: 6553: 6549: 6546: 6542: 6539: 6537: 6534: 6533: 6532: 6529: 6526: 6523: 6521: 6517: 6514: 6512: 6509: 6504: 6501: 6499: 6495: 6492: 6489: 6486: 6484: 6481: 6479: 6476: 6475: 6474: 6471: 6469: 6466: 6463: 6460: 6458: 6454: 6451: 6448: 6445: 6443: 6439: 6437: 6433: 6432:Anaphylatoxin 6430: 6429: 6427: 6423: 6416: 6413: 6411: 6407: 6404: 6401: 6398: 6396: 6392: 6389: 6387: 6383: 6380: 6377: 6374: 6372: 6369: 6367: 6364: 6362: 6358: 6355: 6353: 6350: 6347: 6344: 6342: 6338: 6335: 6332: 6329: 6327: 6323: 6320: 6319: 6317: 6315: 6311: 6308: 6304: 6294: 6291: 6288: 6285: 6283: 6280: 6278: 6275: 6273: 6270: 6268: 6264: 6261: 6259: 6256: 6254: 6251: 6248: 6245: 6243: 6240: 6238: 6235: 6233: 6230: 6228: 6225: 6223: 6220: 6218: 6215: 6213: 6209: 6206: 6203: 6200: 6198: 6195: 6193: 6190: 6188: 6185: 6183: 6180: 6178: 6174: 6171: 6167: 6164: 6162: 6159: 6157: 6154: 6153: 6152: 6149: 6146: 6143: 6141: 6138: 6136: 6133: 6131: 6127: 6124: 6122: 6119: 6117: 6114: 6111: 6108: 6106: 6103: 6101: 6097: 6093: 6090: 6088: 6084: 6081: 6079: 6076: 6075: 6073: 6069: 6063: 6060: 6058: 6055: 6051: 6047: 6044: 6042: 6039: 6037: 6034: 6032: 6028: 6024: 6021: 6019: 6015: 6012: 6011: 6010: 6009:Prostaglandin 6007: 6005: 6002: 6000: 5997: 5993: 5990: 5988: 5985: 5984: 5983: 5980: 5977: 5974: 5972: 5968: 5965: 5964: 5962: 5960: 5956: 5953: 5947: 5936: 5933: 5931: 5928: 5926: 5923: 5921: 5918: 5916: 5913: 5911: 5907: 5904: 5901: 5898: 5896: 5893: 5891: 5887: 5884: 5880: 5877: 5875: 5872: 5870: 5867: 5865: 5862: 5861: 5860: 5857: 5855: 5852: 5848: 5845: 5843: 5840: 5838: 5835: 5833: 5830: 5828: 5825: 5824: 5823: 5820: 5817: 5814: 5812: 5809: 5807: 5804: 5802: 5799: 5797: 5793: 5792:Acetylcholine 5790: 5789: 5787: 5783: 5776: 5773: 5771: 5768: 5766: 5763: 5761: 5757: 5754: 5751: 5748: 5746: 5743: 5741: 5737: 5734: 5731: 5728: 5726: 5723: 5721: 5718: 5716: 5713: 5711: 5707: 5704: 5702: 5697: 5696: 5694: 5692: 5688: 5681: 5678: 5676: 5673: 5671: 5668: 5666: 5663: 5661: 5658: 5656: 5653: 5651: 5648: 5646: 5643: 5641: 5638: 5636: 5633: 5631: 5628: 5626: 5622: 5619: 5616: 5613: 5611: 5608: 5606: 5603: 5601: 5597: 5594: 5593: 5591: 5589: 5585: 5579: 5576: 5574: 5571: 5569: 5566: 5563: 5560: 5558: 5555: 5553: 5549: 5546: 5543: 5540: 5538: 5535: 5533: 5529: 5526: 5525: 5523: 5521: 5517: 5514: 5512: 5508: 5504: 5499: 5495: 5490: 5486: 5482: 5478: 5471: 5466: 5464: 5459: 5457: 5452: 5451: 5448: 5444: 5441: 5440: 5438: 5437:public domain 5434: 5423: 5419: 5414: 5409: 5405: 5401: 5397: 5392: 5388: 5384: 5380: 5376: 5372: 5368: 5363: 5359: 5355: 5351: 5347: 5343: 5342:10.1038/10290 5339: 5335: 5331: 5326: 5322: 5318: 5314: 5310: 5306: 5302: 5296: 5292: 5288: 5283: 5278: 5274: 5270: 5266: 5261: 5257: 5253: 5249: 5245: 5241: 5237: 5233: 5229: 5224: 5220: 5216: 5212: 5208: 5204: 5200: 5196: 5192: 5188: 5184: 5179: 5175: 5171: 5167: 5163: 5159: 5155: 5150: 5146: 5142: 5138: 5134: 5130: 5126: 5120: 5116: 5112: 5108: 5104: 5100: 5096: 5092: 5088: 5084: 5080: 5075: 5071: 5067: 5063: 5059: 5055: 5051: 5047: 5042: 5038: 5034: 5030: 5026: 5022: 5018: 5013: 5009: 5005: 5001: 4997: 4993: 4989: 4984: 4980: 4976: 4972: 4968: 4964: 4960: 4955: 4951: 4947: 4943: 4939: 4935: 4931: 4927: 4923: 4918: 4914: 4910: 4906: 4902: 4898: 4894: 4893:Life Sciences 4889: 4885: 4881: 4877: 4873: 4869: 4865: 4860: 4856: 4852: 4848: 4844: 4840: 4836: 4832: 4828: 4823: 4819: 4815: 4811: 4807: 4803: 4799: 4795: 4791: 4787: 4783: 4778: 4777: 4767: 4763: 4762: 4757: 4753: 4749: 4746: 4742: 4741: 4736: 4735: 4730: 4729: 4717: 4713: 4708: 4703: 4698: 4693: 4689: 4685: 4681: 4674: 4666: 4662: 4658: 4654: 4650: 4646: 4642: 4638: 4631: 4623: 4619: 4614: 4609: 4605: 4601: 4597: 4590: 4582: 4578: 4574: 4570: 4566: 4562: 4558: 4554: 4547: 4545: 4536: 4532: 4528: 4524: 4520: 4516: 4509: 4501: 4497: 4492: 4487: 4483: 4479: 4475: 4468: 4460: 4456: 4452: 4448: 4443: 4438: 4434: 4430: 4426: 4419: 4411: 4407: 4402: 4397: 4393: 4389: 4385: 4378: 4376: 4367: 4363: 4358: 4353: 4349: 4345: 4341: 4334: 4326: 4322: 4317: 4312: 4308: 4304: 4300: 4293: 4285: 4281: 4277: 4273: 4269: 4265: 4258: 4256: 4254: 4245: 4241: 4236: 4231: 4227: 4223: 4219: 4212: 4210: 4201: 4197: 4192: 4187: 4183: 4179: 4175: 4168: 4166: 4164: 4162: 4153: 4149: 4145: 4141: 4137: 4133: 4130:(1): 96–104. 4129: 4125: 4118: 4110: 4106: 4101: 4096: 4092: 4088: 4084: 4080: 4076: 4069: 4067: 4058: 4054: 4049: 4044: 4040: 4036: 4032: 4025: 4023: 4014: 4010: 4006: 4002: 3998: 3994: 3990: 3986: 3982: 3978: 3971: 3969: 3967: 3965: 3963: 3961: 3959: 3957: 3948: 3944: 3939: 3934: 3930: 3926: 3922: 3915: 3907: 3903: 3898: 3893: 3889: 3885: 3881: 3874: 3866: 3862: 3857: 3852: 3848: 3844: 3840: 3836: 3832: 3821: 3813: 3809: 3804: 3799: 3795: 3791: 3787: 3783: 3779: 3768: 3760: 3756: 3751: 3746: 3741: 3736: 3732: 3728: 3724: 3713: 3705: 3701: 3697: 3693: 3689: 3685: 3681: 3677: 3669: 3662: 3654: 3649: 3641: 3637: 3633: 3629: 3625: 3621: 3614: 3606: 3602: 3597: 3592: 3588: 3584: 3580: 3576: 3572: 3565: 3557: 3553: 3549: 3545: 3541: 3537: 3529: 3521: 3517: 3512: 3507: 3502: 3497: 3493: 3489: 3485: 3478: 3470: 3466: 3461: 3456: 3452: 3448: 3444: 3440: 3436: 3429: 3421: 3417: 3413: 3409: 3404: 3399: 3395: 3391: 3387: 3383: 3379: 3372: 3364: 3360: 3356: 3352: 3348: 3344: 3340: 3336: 3328: 3320: 3316: 3311: 3306: 3301: 3296: 3292: 3288: 3284: 3277: 3269: 3265: 3261: 3257: 3250: 3242: 3238: 3234: 3230: 3226: 3222: 3215: 3207: 3203: 3199: 3195: 3191: 3187: 3180: 3172: 3168: 3163: 3158: 3154: 3150: 3146: 3142: 3138: 3131: 3123: 3119: 3115: 3111: 3107: 3103: 3096: 3088: 3084: 3079: 3074: 3070: 3066: 3062: 3058: 3054: 3047: 3031: 3027: 3020:, Driscol J. 3019: 3013: 3005: 3001: 2997: 2993: 2989: 2985: 2978: 2976: 2967: 2963: 2958: 2953: 2948: 2943: 2939: 2935: 2931: 2927: 2923: 2916: 2914: 2905: 2901: 2896: 2891: 2887: 2883: 2879: 2875: 2871: 2864: 2856: 2852: 2847: 2842: 2838: 2834: 2830: 2826: 2819: 2811: 2807: 2802: 2797: 2793: 2789: 2785: 2778: 2776: 2767: 2763: 2758: 2753: 2749: 2745: 2741: 2734: 2726: 2722: 2718: 2714: 2710: 2706: 2702: 2698: 2691: 2683: 2679: 2675: 2671: 2666: 2661: 2657: 2653: 2649: 2642: 2634: 2630: 2626: 2622: 2618: 2614: 2610: 2606: 2599: 2591: 2587: 2582: 2577: 2573: 2569: 2565: 2561: 2557: 2546: 2538: 2534: 2529: 2524: 2519: 2514: 2510: 2506: 2502: 2495: 2487: 2483: 2479: 2475: 2471: 2467: 2459: 2451: 2445: 2437: 2433: 2427: 2419: 2415: 2409: 2402: 2398: 2393: 2391: 2389: 2384: 2375: 2372: 2370: 2367: 2365: 2358: 2356: 2355:5-HT receptor 2353: 2352: 2346: 2342: 2341: 2340:Dysregulation 2337: 2333: 2329: 2325: 2324: 2320: 2316: 2315: 2311: 2302: 2298: 2285: 2276: 2269: 2266: 2263: 2260: 2257: 2256: 2255: 2246: 2244: 2240: 2236: 2230: 2227: 2223: 2219: 2215: 2211: 2207: 2203: 2198: 2196: 2186: 2184: 2174: 2172: 2168: 2151: 2148: 2147: 2146: 2135: 2132: 2130: 2127: 2125: 2122: 2120: 2117: 2115: 2112: 2110: 2107: 2105: 2102: 2100: 2097: 2095: 2092: 2090: 2087: 2085: 2082: 2080: 2077: 2075: 2072: 2067: 2063: 2059: 2055: 2051: 2048: 2045: 2041: 2037: 2033: 2029: 2026: 2025: 2024: 2021: 2018: 2014: 2010: 2006: 2003: 1998: 1994: 1990: 1986: 1983: 1981:most notably) 1980: 1979:Nortriptyline 1976: 1975:Amitriptyline 1972: 1969: 1968: 1967: 1964: 1963: 1953: 1950: 1948: 1945: 1943: 1940: 1938: 1935: 1933: 1930: 1928: 1925: 1923: 1920: 1918: 1915: 1913: 1910: 1908: 1905: 1903: 1900: 1898: 1897:Norfluoxetine 1895: 1893: 1890: 1888: 1885: 1883: 1880: 1878: 1877:Tedatioxetine 1875: 1873: 1870: 1868: 1865: 1863: 1860: 1858: 1855: 1853: 1850: 1848: 1845: 1843: 1840: 1838: 1835: 1834: 1825: 1822: 1821: 1811: 1808: 1806: 1803: 1801: 1798: 1796: 1793: 1791: 1788: 1786: 1783: 1781: 1778: 1776: 1773: 1768: 1764: 1760: 1756: 1752: 1749: 1746: 1742: 1738: 1735: 1732: 1728: 1724: 1720: 1716: 1713: 1710: 1706: 1703: 1702: 1701: 1698: 1696: 1693: 1691: 1688: 1686: 1683: 1681: 1678: 1676: 1673: 1671: 1668: 1666: 1663: 1661: 1658: 1656: 1653: 1651: 1648: 1646: 1643: 1641: 1638: 1636: 1633: 1631: 1628: 1626: 1623: 1621: 1618: 1616: 1613: 1612: 1609: 1594: 1592: 1588: 1584: 1576: 1572: 1558: 1556: 1553: 1549: 1545: 1536: 1521: 1517: 1508: 1506: 1502: 1498: 1482: 1478: 1474: 1470: 1466: 1462: 1455:Endocrinology 1452: 1438: 1433: 1419: 1415: 1411: 1407: 1403: 1394: 1392: 1364: 1360: 1352: 1349: 1333: 1325: 1321: 1317: 1313: 1309: 1296: 1290: 1286: 1282: 1274: 1270: 1262: 1254: 1242: 1238: 1230: 1226: 1222: 1215: 1209:as well as a 1208: 1205: 1194: 1185: 1183: 1179: 1175: 1171: 1167: 1163: 1150: 1148: 1144: 1140: 1126: 1124: 1116: 1112: 1108: 1104: 1100: 1096: 1092: 1088: 1074: 1072: 1062: 1060: 1056: 1053: 1049: 1045: 1042: 1039:and mediates 1038: 1027: 1023: 1020: 1017: 1013: 1009: 992: 987: 983: 979: 976: 972: 965: 963: 960: 956: 952: 948: 943: 939: 932: 930: 924: 920: 917: 911: 909: 905: 901: 895: 891: 888: 884: 877: 875: 869: 865: 862: 856: 854: 850: 846: 840: 836: 833: 831:RefSeq (mRNA) 829: 822: 821: 816: 812: 809: 803: 802: 797: 793: 790: 788: 784: 777: 776: 771: 767: 764: 758: 754: 750: 747: 745: 741: 734: 733: 728: 724: 721: 715: 714: 709: 705: 702: 700: 696: 693: 690: 688: 685: 681: 678: 674: 670: 663: 659: 654: 648: 645: 643: 640: 638: 635: 633: 630: 628: 625: 623: 620: 618: 615: 613: 610: 608: 605: 603: 600: 598: 595: 593: 590: 588: 585: 583: 580: 578: 575: 573: 570: 568: 565: 563: 560: 558: 555: 553: 550: 548: 545: 543: 540: 539: 537: 534: 533: 527: 524: 522: 519: 517: 514: 512: 509: 507: 504: 502: 499: 498: 496: 493: 492: 486: 483: 481: 478: 476: 473: 471: 468: 466: 463: 461: 458: 456: 453: 452: 450: 447: 446: 443: 442:Gene ontology 439: 435: 423: 418: 414: 407: 402: 399: 397: 393: 385: 380: 369: 365: 361: 357: 353: 349: 345: 341: 337: 333: 332: 329: 325: 320: 317: 307: 303: 299: 295: 291: 287: 283: 279: 275: 271: 270: 267: 263: 258: 255: 254: 251: 249: 245: 243: 242: 238: 237: 234: 232: 228: 224: 220: 216: 208: 203: 199: 195: 190: 180: 176: 169: 162: 156: 149: 141: 137: 133: 128: 124: 119: 115: 111: 107: 103: 99: 95: 91: 87: 83: 79: 75: 67: 62: 55: 50: 45: 41: 36: 31: 19: 15040:Superstition 14970: 14965:$ pringfield 14956: 14944: 14937: 14930: 14908: 14901: 14883: 14876: 14869: 14775:Aripiprazole 14757:Clomipramine 14691:Escitalopram 14509: 14450:Neuroanatomy 14367: 14358: 14345: 14336: 14327: 14318: 14307: 14306: 14262: 14250:Vortioxetine 14236:fluphenazine 14210:clomipramine 14105:JNJ-18038683 14095:methysergide 14006:fluperlapine 13986:aripiprazole 13975:Antagonists: 13974: 13939:frovatriptan 13871: 13812: 13777:clomipramine 13685:Landipirdine 13675:Idalopirdine 13660:Cerlapirdine 13607:fluperlapine 13591:aripiprazole 13579:Antagonists: 13578: 13487:methysergide 13451: 13412:methysergide 13400: 13371:Antagonists: 13370: 13321: 13255:Antagonists: 13254: 13197:Prucalopride 13143: 13101: 13079:Vortioxetine 12993:Palonosetron 12882:Antagonists: 12881: 12759: 12691: 12673:thioridazine 12509:Medifoxamine 12464:methysergide 12416:Deramciclane 12370:paliperidone 12354:fluperlapine 12325:Antagonists: 12324: 12204:aripiprazole 12087:ergine (LSA) 11930: 11915: 11893: 11798:Sarpogrelate 11648:aripiprazole 11632:Antagonists: 11631: 11508:methysergide 11443:fenfluramine 11427:Amphetamines 11413: 11372: 11350:Volinanserin 11336:thioridazine 11308:perphenazine 11296:fluphenazine 11238:Teniloxazine 11189:Sarpogrelate 11179:Roluperidone 11149:Pimavanserin 11129:Nelotanserin 11104:Medifoxamine 11089:Landipirdine 11049:methysergide 11020:Eplivanserin 11010:Deramciclane 10965:paliperidone 10933:fluperlapine 10921:clocapramine 10917:carpipramine 10901:aripiprazole 10846:5-MeO-NBpBrT 10838:Antagonists: 10837: 10610:ergine (LSA) 10432:2CBFly-NBOMe 10391: 10339:Antagonists: 10338: 10282:methysergide 10253: 10209: 10194:Antagonists: 10193: 10155:methysergide 10142: 10092: 9997:Antagonists: 9996: 9953:zolmitriptan 9937:frovatriptan 9871:methysergide 9828: 9783: 9679:Antagonists: 9678: 9666:Vortioxetine 9633:zolmitriptan 9588:methysergide 9529: 9482: 9450:Spiroxatrine 9269:Antagonists: 9268: 9019:methysergide 8936:tandospirone 8882:aripiprazole 8872:vortioxetine 8825: 8746:Gap junction 8581:Ca signaling 8544:Cell surface 8108: 8075: 8048:Metabotropic 7912: 7797: 7750: 7708: 7674: 7645: 7616: 7461: 7086: 6935: 6886:Urotensin-II 6826:Somatostatin 6781:Prokineticin 6678:Melanocortin 6381: 6314:Neuropeptide 6253:Oxoglutarate 6095: 6057:Prostacyclin 6026: 6013: 5966: 5854:GHB receptor 5755: 5749: 5698: 5442: 5430: 5429: 5403: 5399: 5370: 5366: 5333: 5329: 5304: 5300: 5272: 5269:FEBS Letters 5268: 5231: 5227: 5186: 5182: 5157: 5153: 5128: 5124: 5082: 5078: 5053: 5049: 5020: 5016: 4991: 4987: 4962: 4958: 4925: 4921: 4896: 4892: 4867: 4863: 4830: 4826: 4788:(1): 38–48. 4785: 4781: 4759: 4739: 4733: 4687: 4683: 4673: 4643:(1): 69–76. 4640: 4636: 4630: 4603: 4599: 4589: 4556: 4552: 4518: 4514: 4508: 4481: 4477: 4467: 4432: 4428: 4418: 4391: 4387: 4347: 4343: 4333: 4306: 4302: 4292: 4270:(1): 70–78. 4267: 4263: 4225: 4221: 4181: 4177: 4127: 4123: 4117: 4082: 4078: 4038: 4034: 3980: 3976: 3928: 3925:FEBS Letters 3924: 3914: 3887: 3883: 3873: 3838: 3834: 3820: 3785: 3781: 3767: 3730: 3726: 3712: 3679: 3675: 3668: 3660: 3648: 3626:(1): 15–27. 3623: 3619: 3613: 3581:(1): 10–13. 3578: 3574: 3564: 3539: 3535: 3534:receptors". 3528: 3491: 3487: 3477: 3442: 3438: 3428: 3385: 3381: 3371: 3338: 3334: 3327: 3290: 3286: 3276: 3259: 3255: 3249: 3224: 3220: 3214: 3189: 3185: 3179: 3144: 3140: 3130: 3105: 3101: 3095: 3060: 3056: 3046: 3034:. Retrieved 3029: 3012: 2987: 2983: 2929: 2925: 2877: 2873: 2863: 2828: 2818: 2791: 2787: 2747: 2743: 2733: 2700: 2696: 2690: 2655: 2652:FEBS Letters 2651: 2641: 2608: 2604: 2598: 2563: 2559: 2545: 2508: 2504: 2494: 2469: 2465: 2458: 2444: 2435: 2426: 2417: 2408: 2343: 2339: 2338: 2334: 2330: 2326: 2322: 2321: 2317: 2313: 2312: 2308: 2305:Consequences 2299: 2291: 2282: 2279:Conservation 2273: 2252: 2231: 2199: 2192: 2180: 2160: 2157:Interactions 2144: 2099:Methiothepin 2079:Deramciclane 2044:Thioridazine 2036:Fluphenazine 2017:Latrepirdine 1985:Tetracyclics 1912:Promethazine 1882:Methysergide 1824:Aripiprazole 1705:Lysergamides 1700:Psychedelics 1635:Fenfluramine 1564: 1548:progesterone 1537: 1509: 1461:hypothalamus 1458: 1434: 1395: 1350: 1332:downregulate 1310:of SSRI and 1308:side effects 1297: 1287:, including 1186: 1178:hypothalamus 1151: 1132: 1080: 1077:Distribution 1068: 1050:denotes the 1047: 1003: 1001: 926: 908:NP_001243690 904:NP_001243689 897: 871: 853:NM_001256760 845:NM_001256761 842: 818: 799: 773: 756: 730: 711: 691: 686: 292:hypothalamus 246: 239: 205:145,980,273 192:145,745,509 69:External IDs 15071:Human genes 14972:Straight Up 14952:Adrian Monk 14939:The Aviator 14701:Fluvoxamine 14656:possessions 14607:Compulsions 14571:associative 14320:Adrenergics 14280:Piperazines 14196:mirtazapine 14188:maprotiline 14099:sergolexole 14091:metergoline 14087:mesulergine 14067:cabergoline 14046:EGIS-12,233 14026:ziprasidone 14014:risperidone 13998:clorotepine 13982:amisulpride 13945:Tryptamines 13838:Piperazines 13695:Masupirdine 13665:EGIS-12,233 13611:iloperidone 13599:clorotepine 13503:Tryptamines 13483:metergoline 13479:mesulergine 13418:Piperazines 13408:metergoline 13348:Tryptamines 13232:Usmarapride 13187:Minesapride 13162:Cinitapride 13110:Piperazines 13069:sevoflurane 13046:Tropisetron 13041:Tropanserin 13030:mirtazapine 12988:Ondansetron 12968:Granisetron 12943:Cilansetron 12928:Batanopride 12895:Arazasetron 12890:Anpirtoline 12829:Tryptamines 12791:Piperazines 12669:pipamperone 12618:mirtazapine 12610:maprotiline 12584:SDZ SER-082 12534:Propranolol 12524:Pirenperone 12474:Etoperidone 12468:sergolexole 12460:metergoline 12456:mesulergine 12431:Eltoprazine 12386:ziprasidone 12378:risperidone 12358:iloperidone 12346:clorotepine 12333:Agomelatine 12328:Adatanserin 12297:Vabicaserin 12251:Tryptamines 12200:Piperazines 12079:cabergoline 11855:mirtazapine 11833:SDZ SER-082 11783:Rauwolscine 11773:Propranolol 11763:Pirenperone 11732:mesulergine 11692:ziprasidone 11688:risperidone 11680:pipamperone 11660:cariprazine 11644:amisulpride 11635:Agomelatine 11570:Tryptamines 11545:Piperazines 11488:cabergoline 11384:nicergoline 11340:thiothixene 11316:pipamperone 11300:haloperidol 11272:mirtazapine 11264:maprotiline 11210:mepiprazole 11198:etoperidone 11169:Rauwolscine 11164:Pruvanserin 11154:Pirenperone 11069:Glemanserin 11064:Flibanserin 11053:sergolexole 11045:metergoline 11041:mesulergine 10985:ziprasidone 10981:zicronapine 10973:risperidone 10957:ocaperidone 10953:mosapramine 10941:iloperidone 10937:gevotroline 10925:clorotepine 10909:blonanserin 10874:hydroxyzine 10856:Adatanserin 10784:Tryptamines 10751:Piperazines 10606:cabergoline 10424:2CBCB-NBOMe 10420:25TFM-NBOMe 10321:Tryptamines 10315:sumatriptan 10311:naratriptan 10176:Tryptamines 10096:Acetryptine 10080:Ziprasidone 10019:metergoline 9959:Tryptamines 9949:sumatriptan 9945:rizatriptan 9941:naratriptan 9929:donitriptan 9921:almotriptan 9855:cabergoline 9791:cabergoline 9730:metergoline 9711:propranolol 9644:Tryptamines 9629:sumatriptan 9621:donitriptan 9563:Eltoprazine 9533:Anpirtoline 9486:Acetryptine 9435:SDZ 216-525 9375:Flopropione 9364:metergoline 9335:propranolol 9280:risperidone 9276:iloperidone 9189:Tryptamines 9134:Rauwolscine 9124:Pardoprunox 9064:Flibanserin 8995:cabergoline 8982:Enciprazine 8977:Eltoprazine 8957:Cannabidiol 8932:perospirone 8910:ziprasidone 8894:cariprazine 8848:etoperidone 8839:Amphetamine 8834:Adatanserin 8657:By distance 8595:Assistants: 8554:Co-receptor 7756:Latrophilin 6891:Vasopressin 6876:Thyrotropin 6453:Angiotensin 6406:Neurotensin 6083:Cannabinoid 6062:Thromboxane 3659:Database". 2183:RNA editing 2177:RNA editing 2094:Metergoline 2066:Ziprasidone 2062:Risperidone 2013:Hydroxyzine 1989:Mirtazapine 1942:SDZ SER-082 1887:Mirtazapine 1862:Flibanserin 1857:Etoperidone 1852:Eltoprazine 1837:Agomelatine 1830:Antagonists 1795:WAY-163,909 1790:WAY-161,503 1780:Vabicaserin 1751:Tryptamines 1737:Piperazines 1685:PF-04479745 1650:Mesulergine 1555:hippocampus 1501:sympathetic 1477:vasopressin 1410:amphetamine 1324:venlafaxine 1289:mirtazapine 1193:Agomelatine 1174:hippocampus 1091:hippocampus 47:Identifiers 15065:Categories 14895:Nonfiction 14856:Literature 14809:Behavioral 14739:Phenelzine 14721:Nefazodone 14716:Citalopram 14711:Sertraline 14706:Paroxetine 14696:Fluoxetine 14596:scrupulous 14586:pathogenic 14576:diagnostic 14567:Obsessions 14214:imipramine 14175:SSR-181507 14150:SB-656104A 14125:Ritanserin 14115:LY-215,840 14110:Ketanserin 14083:LY-215,840 14075:ergotamine 14059:amesergide 14036:Butaclamol 14022:tiospirone 14018:sertindole 14010:olanzapine 13885:Bifeprunox 13828:lergotrile 13725:Ro 63-0563 13720:Ro 04-6790 13715:Ritanserin 13680:Ketanserin 13619:tiospirone 13615:olanzapine 13566:WAY-208466 13561:WAY-181187 13555:tryptamine 13535:EMD-386088 13467:ergotamine 13389:Ritanserin 13333:ergotamine 13237:Velusetrag 13207:Renzapride 13089:Zatosetron 13008:Ricasetron 13003:Renzapride 12998:Ramosetron 12978:Lerisetron 12958:Dolasetron 12917:quetiapine 12913:olanzapine 12855:isoflurane 12679:Xylamidine 12602:aptazapine 12539:Ritanserin 12519:Nefazodone 12494:Ketanserin 12489:Irindalone 12479:Fluoxetine 12452:LY-215,840 12440:amesergide 12426:Dotarizine 12406:Cinanserin 12396:Captodiame 12382:sertindole 12374:quetiapine 12366:olanzapine 12307:WAY-161503 12291:tryptamine 12287:psilocybin 12231:PNU-181731 12190:lophophine 12176:Oxaflozane 12134:Lorcaserin 12129:Flumexadol 12091:ergotamine 11972:5-MeO-DiPT 11788:Ritanserin 11753:Metadoxine 11738:Ketanserin 11712:amesergide 11684:quetiapine 11676:olanzapine 11618:tryptamine 11614:psilocybin 11518:Lorcaserin 11500:ergotamine 11355:Xylamidine 11324:setoperone 11256:aptazapine 11243:Temanogrel 11214:nefazodone 11206:lubazodone 11174:Ritanserin 11139:Pelanserin 11079:Ketanserin 11074:Irindalone 11059:Fananserin 11037:LY-215,840 11029:amesergide 11015:Dotarizine 11000:Cinanserin 10977:sertindole 10969:quetiapine 10961:olanzapine 10945:lurasidone 10897:amperozide 10861:Altanserin 10841:5-I-R91150 10824:tryptamine 10820:psilocybin 10741:lophophine 10722:PNU-181731 10707:Oxaflozane 10675:Lorcaserin 10670:Jimscaline 10660:Flumexadol 10618:ergotamine 10486:5-MeO-DiPT 10307:eletriptan 10288:Lasmiditan 10262:CP-122,288 10180:tryptamine 10170:eletriptan 10070:Ritanserin 10030:Ketanserin 10005:BRL-15,572 9933:eletriptan 9925:avitriptan 9902:PNU-142633 9897:PNU-109291 9863:ergotamine 9832:CP-122,288 9741:Isamoltane 9715:tertatolol 9707:penbutolol 9703:oxprenolol 9699:isamoltane 9691:alprenolol 9682:AR-A000002 9625:eletriptan 9617:avitriptan 9580:ergotamine 9553:CP-122,288 9538:CGS-12066A 9491:Carvedilol 9470:Xylamidine 9465:WAY-100635 9460:WAY-100135 9430:SB-649,915 9420:Robalzotan 9385:Isamoltane 9355:Dotarizine 9339:tertatolol 9323:penbutolol 9319:oxprenolol 9315:isamoltane 9299:alprenolol 9284:sertindole 9251:Xaliproden 9246:Vilazodone 9236:U-92,016-A 9225:psilocybin 9213:indorenate 9184:Sunepitron 9179:SSR-181507 9129:Piclozotan 9119:Oxaflozane 9114:Osemozotan 9079:Lesopitron 9069:Flumexadol 9059:Flesinoxan 9003:ergotamine 8942:Bay R 1531 8924:eptapirone 8916:Azapirones 8906:quetiapine 8902:lurasidone 8868:vilazodone 8856:nefazodone 8791:modulators 8724:Pheromones 8664:Juxtacrine 8346:Smoothened 8339:Smoothened 8262:Smoothened 7921:Calcitonin 6856:Tachykinin 6753:, but not 6747:Nociceptin 6613:Kisspeptin 6531:Endothelin 6494:Bradykinin 6382:Neuromedin 5959:Eicosanoid 5588:Purinergic 5520:Adrenergic 3733:: 606414. 2403:, May 2017 2380:References 2288:Regulation 2134:SB-242,084 2129:SB-243,213 2124:SB-228,357 2119:SB-206,553 2109:Ritanserin 2084:Ketanserin 2074:Cinanserin 2058:Olanzapine 1971:Tricyclics 1937:SB-242,084 1932:SB-228,357 1927:SB-221,284 1922:SB-200,646 1917:RS-102,221 1907:Olanzapine 1892:Nefazodone 1872:FR-260,010 1867:Fluoxetine 1810:CP-132,484 1800:WAY-261240 1695:PNU-181731 1680:Oxaflozane 1675:ORG-37,684 1670:Org 12,962 1645:Lorcaserin 1625:CP-809,101 1320:paroxetine 1316:sertraline 1263:block 5-HT 1241:fluoxetine 1207:antagonist 1123:ventricles 1101:, several 1041:excitatory 1016:endogenous 250:(ortholog) 90:HomoloGene 14878:Plyushkin 14863:Fictional 14666:Treatment 14581:injurious 14486:Receptors 14308:See also: 14274:pergolide 14266:Ergolines 14192:mianserin 14184:amoxapine 14170:Spiperone 14155:SB-691673 14145:SB-656104 14140:SB-269970 14135:SB-258741 14130:SB-258719 14051:Ergolines 14002:clozapine 13990:asenapine 13961:N-Me-5-HT 13957:bufotenin 13925:Sarizotan 13920:RU-24,969 13895:Ergolines 13875:8-OH-DPAT 13872:Agonists: 13832:pergolide 13816:Ergolines 13763:mianserin 13759:amoxapine 13750:SB-742457 13745:SB-399885 13740:SB-357134 13735:SB-271046 13730:SB-258585 13710:PRX-07034 13670:GW-742457 13655:BVT-74316 13645:BGC20-760 13603:clozapine 13595:asenapine 13547:N-Me-5-HT 13543:LY-586713 13523:Bufotenin 13507:2-Me-5-HT 13455:Ergolines 13452:Agonists: 13404:Ergolines 13394:SB-699551 13374:Asenapine 13325:Ergolines 13322:Agonists: 13293:SB-204070 13288:SB-203186 13273:Piboserod 13263:GR-125487 13258:GR-113808 13242:Zacopride 13227:Tegaserod 13217:RS-67,506 13212:RS-67,333 13202:PRX-03140 13192:Mosapride 13177:Dazopride 13172:CJ-033466 13167:Cisapride 13157:Capeserod 13144:Agonists: 13084:Zacopride 13026:mianserin 13022:amoxapine 12983:Memantine 12953:Dazopride 12938:Bupropion 12923:Azasetron 12909:clozapine 12885:Alosetron 12851:halothane 12833:2-Me-5-HT 12824:SR-57227A 12803:quipazine 12760:Agonists: 12700:Ergolines 12695:Efavirenz 12634:Trazodone 12614:mianserin 12598:amoxapine 12579:SB-243213 12574:SB-242084 12569:SB-228357 12564:SB-221284 12559:SB-206553 12554:SB-200646 12544:RS-102221 12529:Pizotifen 12499:Ketotifen 12484:FR-260010 12436:Ergolines 12362:melperone 12350:clozapine 12342:asenapine 12263:bufotenin 12241:Ro60-0213 12236:Ro60-0175 12226:PNU-22394 12216:quipazine 12194:mescaline 12181:PHA-57378 12171:ORG-37684 12166:ORG-12962 12123:pergolide 12071:Ergolines 12044:Dimemebfe 12039:CP-809101 12034:Alstonine 12029:AL-38022A 12010:α-Me-5-HT 12006:5-MeO-αMT 12002:5-MeO-αET 11980:5-MeO-DPT 11976:5-MeO-DMT 11968:5-MeO-DET 11931:Agonists: 11897:Ergolines 11881:Yohimbine 11861:Trazodone 11851:mianserin 11847:amoxapine 11838:Tegaserod 11828:SB-228357 11823:SB-221284 11818:SB-215505 11813:SB-206553 11808:SB-204741 11803:SB-200646 11793:RS-127445 11778:PRX-08066 11768:Pizotifen 11743:LY-393558 11728:LY-272015 11708:Ergolines 11703:EGIS-7625 11664:clozapine 11652:asenapine 11590:bufotenin 11586:α-Me-5-HT 11560:Ro60-0175 11555:PNU-22394 11512:pergolide 11484:Ergolines 11457:BW-723C86 11414:Agonists: 11376:Ergolines 11360:Yohimbine 11332:spiramide 11328:spiperone 11268:mianserin 11252:amoxapine 11228:SR-46349B 11222:trazodone 11159:Pizotifen 11124:Nantenine 11094:LY-393558 11025:Ergolines 10949:melperone 10929:clozapine 10905:asenapine 10882:perlapine 10878:ketotifen 10796:bufotenin 10759:quipazine 10745:mescaline 10717:PNU-22394 10712:PHA-57378 10665:IHCH-7113 10654:pergolide 10590:Ergolines 10585:Efavirenz 10553:Dimemebfe 10543:AL-37350A 10524:α-Me-5-HT 10520:5-MeO-αMT 10516:5-MeO-αET 10494:5-MeO-DPT 10490:5-MeO-DMT 10482:5-MeO-DET 10428:25CN-NBOH 10416:25C-NBOMe 10412:25B-NBOMe 10408:25I-NBOMe 10392:Agonists: 10347:Mianserin 10293:LY-334370 10267:Ergolines 10257:BRL-54443 10254:Agonists: 10213:Ergolines 10151:Ergolines 10146:BRL-54443 10143:Agonists: 10113:pergolide 10101:Ergolines 10075:Yohimbine 10065:Mianserin 10055:LY-456220 10050:LY-456219 10045:LY-393558 10040:LY-367642 10035:LY-310762 10025:GR-127935 10015:Ergolines 10010:Elzasonan 10000:Alniditan 9847:Ergolines 9842:CP-286601 9837:CP-135807 9829:Agonists: 9787:Ergolines 9771:Yohimbine 9766:SB-236057 9761:SB-224289 9756:SB-216641 9746:LY-393558 9736:GR-127935 9726:Ergolines 9721:Elzasonan 9695:carteolol 9603:RU-24,969 9592:pergolide 9568:Ergolines 9558:CP-135807 9530:Agonists: 9496:Ergolines 9445:Spiramide 9440:Spiperone 9390:Lecozotan 9370:FCE-24379 9360:Ergolines 9345:BMY-7,378 9327:pindobind 9303:carteolol 9256:Yohimbine 9217:N-Me-5-HT 9205:bufotenin 9197:5-MeO-DMT 9169:Sarizotan 9149:RU-24,969 9144:Roxindole 9139:Repinotan 9104:Naluzotan 9089:LY-301317 9084:LY-293284 9023:pergolide 8987:Ergolines 8972:Ebalzotan 8962:Dimemebfe 8952:BMY-14802 8947:Befiradol 8920:buspirone 8898:clozapine 8886:asenapine 8860:trazodone 8829:8-OH-DPAT 8826:Agonists: 8678:Endocrine 8673:Paracrine 8669:Autocrine 8536:Receptors 8516:Cytokines 8256:Class F: 8055:pheromone 8051:glutamate 7475:Olfactory 6511:Chemokine 6293:Succinate 6078:Bile acid 5886:Melatonin 5859:Histamine 5699:(all but 5691:Serotonin 5596:Adenosine 5498:Rhodopsin 5358:195213008 3778:Receptor" 3036:14 August 3026:Database" 2314:Structure 2214:guanosine 2104:Pizotifen 2089:LY-53,857 2054:Clozapine 2050:Atypicals 1997:Amoxapine 1993:Mianserin 1952:Trazodone 1847:Clozapine 1775:Ro60-0175 1759:Bufotenin 1755:5-MeO-DMT 1731:Mescaline 1690:PNU-22394 1620:AL-38022A 1615:A-372,159 1544:estradiol 1469:prolactin 1273:receptors 1239:(but not 1139:serotonin 1103:brainstem 1071:homodimer 1065:Structure 1022:serotonin 929:NP_032338 900:NP_000859 874:NM_008312 849:NM_000868 677:Orthologs 98:GeneCards 14885:Xenocide 14795:Inositol 14637:Hoarding 14611:impulses 14601:symmetry 14560:Symptoms 14518:μ Opioid 14461:striatum 14270:lisuride 14244:pimozide 14240:loxapine 14079:LY-53857 14030:zotepine 13935:Triptans 13799:loxapine 13650:BVT-5182 13493:Hypidone 13471:lisuride 13283:RS-67532 13278:RS-39604 13268:L-Lysine 13105:LY-53857 13055:loxapine 12948:CSP-2503 12869:YM-31636 12819:SR-57227 12809:RS-56812 12763:Alcohols 12665:pimozide 12661:loxapine 12629:Tramadol 12448:LY-53857 12390:zotepine 12283:psilocin 12099:LA-SS-Az 12095:lisuride 12024:A-372159 11998:5-Fl-αMT 11994:5-Cl-αMT 11724:LY-53857 11720:lisuride 11610:psilocin 11435:cloforex 11422:Aminorex 11312:pimozide 11304:loxapine 11233:TGBA01AD 11033:LY-53857 11005:CSP-2503 10989:zotepine 10851:AC-90179 10816:psilocin 10626:LA-SS-Az 10622:lisuride 10538:AL-34662 10512:5-Fl-αMT 10508:5-Cl-αMT 10468:2C-B-FLY 10404:25I-NBOH 10400:25I-NBMD 10303:Triptans 10275:lysergol 10221:lysergol 10166:Triptans 10109:lysergol 10105:lisuride 9971:5-Et-DMT 9917:Triptans 9912:TGBA01AD 9887:L-772405 9882:L-694247 9877:GR-46611 9799:lisuride 9613:Triptans 9548:CP-94253 9543:CP-93129 9380:GR-46611 9350:CSP-2503 9331:pindolol 9241:Urapidil 9231:TGBA01AD 9221:psilocin 9154:S-14,506 9074:Hypidone 9054:F-15,599 9029:F-11,461 9007:lisuride 8967:Dopamine 8928:gepirone 8498:Hormones 8448:JAK-STAT 8436:MAPK/ERK 8431:TGF beta 8280:Frizzled 8273:Frizzled 8258:Frizzled 8100:, type 2 8006:Secretin 7946:Glucagon 7651:Cadherin 7609:Adhesion 7596:Secretin 6929:, bitter 6776:Oxytocin 6473:Bombesin 6121:Estrogen 5822:Dopamine 5422:10816555 5387:10581480 5350:10391209 5321:10206230 5256:21333874 5154:Genomics 5050:Genomics 4979:16433010 4959:Therapie 4950:30964513 4942:15953671 4913:12650852 4884:11916537 4855:25543069 4847:11888546 4818:25127011 4716:12486144 4665:25363004 4657:16005997 4622:11988167 4581:24977282 4573:12853111 4500:14602721 4459:25007217 4451:10432492 4410:14615479 4366:15492466 4325:16082172 4284:15093687 4244:10693963 4200:10092629 4144:16580757 4109:15087490 4057:10432493 3906:11150294 3865:32567857 3812:29620897 3759:33324228 3704:11363664 3696:22178753 3640:20840530 3605:21827831 3556:24878222 3520:28588509 3469:18500341 3420:44527461 3412:16357227 3355:11834317 3319:17596444 3268:18208678 3241:17017968 3206:16475959 3171:24196946 3087:11607047 3004:16269190 2904:29477251 2855:24343836 2846:11289707 2810:11282248 2766:17451451 2725:11405860 2717:15668911 2682:23825490 2633:45542707 2590:29398112 2537:22593582 2399:– 2364:receptor 2349:See also 2323:Function 2292:The 5-HT 2249:Location 2241:(UTRs), 2210:Inosines 2195:pre-mRNA 2167:interact 2161:The 5-HT 2152:CTW-0415 2149:CYD-1-79 2040:Loxapine 2028:Typicals 1947:Tramadol 1767:Psilocin 1640:Lisuride 1602:Agonists 1587:SNORD115 1561:Genetics 1497:HPA axis 1487:and 5-HT 1481:oxytocin 1437:cytokine 1414:morphine 1406:nicotine 1402:caffeine 1281:reuptake 1182:amygdala 1162:striatum 1143:dopamine 1133:The 5-HT 1129:Function 1107:amygdala 1105:nuclei, 1059:receptor 1008:receptor 975:Wikidata 656:Sources: 526:dendrite 506:membrane 14987:Related 14641:animals 14616:rituals 14442:Biology 14420:History 14282:(e.g., 14268:(e.g., 14222:(e.g., 14204:(e.g., 14182:(e.g., 14165:SLV-314 14160:SLV-313 14053:(e.g., 14041:DR-4485 13980:(e.g., 13947:(e.g., 13937:(e.g., 13897:(e.g., 13890:E-55888 13840:(e.g., 13818:(e.g., 13793:(e.g., 13781:doxepin 13771:(e.g., 13757:(e.g., 13640:AVN-397 13635:AVN-322 13630:AVN-211 13625:AVN-101 13589:(e.g., 13582:ABT-354 13551:ST-1936 13505:(e.g., 13457:(e.g., 13420:(e.g., 13406:(e.g., 13350:(e.g., 13327:(e.g., 13112:(e.g., 13063:(e.g., 13053:(e.g., 13036:Thujone 13020:(e.g., 12907:(e.g., 12900:AS-8112 12859:toluene 12849:(e.g., 12831:(e.g., 12793:(e.g., 12767:butanol 12765:(e.g., 12702:(e.g., 12655:(e.g., 12641:(e.g., 12624:TIK-301 12596:(e.g., 12549:S-14671 12438:(e.g., 12340:(e.g., 12302:WAY-629 12253:(e.g., 12202:(e.g., 12188:(e.g., 12141:(e.g., 12111:LSD-Pip 12073:(e.g., 12051:(e.g., 11992:(e.g., 11958:2C-T-21 11936:(e.g., 11899:(e.g., 11876:TIK-301 11868:(e.g., 11845:(e.g., 11710:(e.g., 11642:(e.g., 11572:(e.g., 11547:(e.g., 11525:(e.g., 11486:(e.g., 11464:(e.g., 11429:(e.g., 11378:(e.g., 11290:(e.g., 11280:(e.g., 11250:(e.g., 11196:(e.g., 11184:S-14671 11084:KML-010 11027:(e.g., 10895:(e.g., 10868:(e.g., 10786:(e.g., 10753:(e.g., 10739:(e.g., 10682:(e.g., 10638:LSD-Pip 10592:(e.g., 10565:(e.g., 10506:(e.g., 10473:2CB-Ind 10462:2C-T-21 10440:(e.g., 10396:25I-NBF 10323:(e.g., 10305:(e.g., 10269:(e.g., 10215:(e.g., 10178:(e.g., 10168:(e.g., 10153:(e.g., 10103:(e.g., 10017:(e.g., 9961:(e.g., 9919:(e.g., 9849:(e.g., 9789:(e.g., 9728:(e.g., 9689:(e.g., 9646:(e.g., 9615:(e.g., 9570:(e.g., 9498:(e.g., 9425:S-15535 9415:NAN-190 9362:(e.g., 9297:(e.g., 9274:(e.g., 9191:(e.g., 9164:S-15535 9159:S-14671 9099:MKC-242 9049:F-15063 9044:F-14679 9039:F-13714 9034:F-12826 8989:(e.g., 8918:(e.g., 8880:(e.g., 8846:(e.g., 8629:General 8453:Akt/PKB 8069:, sweet 8044:Class C 7976:PACAPR1 7592:Class B 6801:Relaxin 6723:Motilin 6608:Ghrelin 6573:Galanin 6306:Peptide 5494:Class A 5291:9537516 5248:9241279 5219:4247011 5211:9153397 5191:Bibcode 5174:8812491 5145:7895773 5115:4368727 5107:7700379 5087:Bibcode 5070:7557992 5037:1722404 5008:1302605 4810:9928237 4790:Bibcode 4766:PDBe-KB 4756:UniProt 4707:6758441 4535:7792930 4152:3799598 4013:4247011 4005:9153397 3985:Bibcode 3947:9537516 3856:8434884 3803:6533912 3750:7724505 3653:Roth BL 3596:3213641 3511:5438973 3460:2705197 3390:Bibcode 3382:Science 3363:6902168 3310:6672238 3162:3957106 3122:9090573 3078:6494141 3022:"PDSP K 3018:Roth BL 2966:9050900 2934:Bibcode 2895:5889788 2697:Synapse 2674:2714444 2625:8788961 2581:6309861 2528:3390635 2486:7895773 2401:Ensembl 2235:introns 2206:inosine 2114:S-32212 2068:, etc.) 2046:, etc.) 2019:, etc.) 1999:, etc.) 1785:WAY-629 1769:, etc.) 1747:, etc.) 1733:, etc.) 1711:, etc.) 1597:Ligands 1585:called 1575:obesity 1552:ventral 1418:cocaine 1351:in vivo 1338:, 5-HT1 1253:synapse 787:UniProt 744:Ensembl 683:Species 662:QuickGO 296:putamen 225:pattern 54:Aliases 15015:PANDAS 14591:sexual 13915:LP-211 13705:MS-245 13531:E-6837 13527:E-6801 12781:m-CPBG 12312:YM-348 12161:MK-212 12075:ALD-52 11954:2C-T-7 11950:2C-T-2 10779:TFMFly 10702:O-4310 10598:ALD-52 10594:1P-LSD 10558:DMBMPP 10458:2C-T-7 10454:2C-T-2 9455:UH-301 9395:Mefway 8482:Agents 8260:& 8189:GPRC6A 7926:CALCRL 7790:Orphan 7079:Orphan 7070:type 1 6761:Orexin 6749:& 6728:Opioid 6468:Apelin 5420: 5385: 5356: 5348: 5319: 5289: 5254: 5246: 5217: 5209: 5183:Nature 5172: 5143: 5113: 5105: 5079:Nature 5068: 5035: 5006: 4977: 4948: 4940: 4911: 4882: 4853: 4845: 4816: 4808: 4761:P28335 4731:Human 4714: 4704: 4663: 4655: 4620: 4600:Neuron 4579: 4571: 4533: 4498: 4457: 4449: 4408: 4364: 4323: 4282: 4242: 4198: 4150: 4142: 4107: 4100:407821 4097: 4055: 4011: 4003: 3977:Nature 3945: 3904: 3863: 3853: 3810: 3800: 3757: 3747: 3702: 3694: 3638: 3603: 3593: 3554: 3518: 3508: 3494:: 89. 3467: 3457: 3418: 3410: 3361: 3353: 3317: 3307: 3266: 3239: 3204: 3169: 3159: 3120: 3085: 3075: 3002: 2964: 2954: 2902: 2892: 2874:Lancet 2853: 2843: 2808: 2764: 2723: 2715: 2680: 2672: 2631: 2623: 2588: 2578: 2535: 2525: 2484: 1805:YM-348 1655:MK-212 1583:snoRNA 1359:ligand 1180:, and 1117:. 5-HT 961:search 959:PubMed 820:P34968 801:P28335 699:Entrez 396:BioGPS 78:312861 18:5-HT2C 14924:Media 14788:Other 14646:books 13910:LP-44 13905:LP-12 13880:AS-19 13152:BIMU8 13073:xenon 12220:TFMPP 11549:TFMPP 10774:TCB-2 10763:TFMPP 10727:RH-34 9639:TFMPP 9290:AV965 9109:NBUMP 8644:TFIIH 8639:TFIID 8463:Hippo 8443:Notch 8109:Other 8076:TAS1R 8067:Taste 7965:GLP2R 7960:GLP1R 7913:Other 7778:ELTD1 7751:ADGRL 7709:ADGRG 7675:ADGRE 7646:ADGRC 7617:ADGRB 7598:-like 7480:Opsin 7462:Other 6936:TAS2R 6927:Taste 6755:Sigma 6737:Kappa 6732:Delta 6440:C5a ( 6425:Other 6071:Other 5999:FPRL1 5967:CysLT 5785:Other 5736:5-HT2 5706:5-HT1 5701:5-HT3 5500:-like 5354:S2CID 5252:S2CID 5215:S2CID 5111:S2CID 4946:S2CID 4851:S2CID 4814:S2CID 4740:HTR2C 4734:HTR2C 4661:S2CID 4577:S2CID 4455:S2CID 4148:S2CID 4009:S2CID 3700:S2CID 3416:S2CID 3359:S2CID 2957:20038 2721:S2CID 2678:S2CID 2629:S2CID 2552:"5-HT 2243:LINEs 2226:ADAR3 2222:ADAR2 2218:ADAR1 2169:with 1745:TFMPP 1630:CPD-1 1237:SSRIs 1052:human 1048:HTR2C 732:15560 692:Mouse 687:Human 658:Amigo 248:Mouse 241:Human 188:Start 123:Mouse 102:HTR2C 94:20242 86:96281 61:HTR2C 33:HTR2C 14958:Pure 14651:data 14621:tics 14547:NMDA 14510:5-HT 14502:5-HT 14493:5-HT 14349:and 13953:5-MT 13949:5-CT 13857:5-HT 13539:EMDT 13519:5-MT 13515:5-CT 13511:5-BT 13437:5-HT 13352:5-CT 13307:5-HT 13147:5-MT 13129:5-HT 12837:5-CT 12799:mCPP 12745:5-HT 12727:5-HT 12401:CEPC 12271:DiPT 12259:5-CT 12255:5-BT 12212:mCPP 12155:MMDA 12151:MDOH 12139:MDxx 11984:5-MT 11946:2C-I 11942:2C-E 11938:2C-B 11916:5-HT 11748:mCPP 11598:DiPT 11582:5-MT 11578:5-CT 11574:5-BT 11539:MMDA 11535:MDOH 11523:MDxx 11399:5-HT 11099:mCPP 10888:AMDA 10804:DiPT 10792:5-CT 10788:5-BT 10696:MMDA 10692:MDOH 10680:MDxx 10498:5-MT 10450:2C-I 10446:2C-E 10442:2C-B 10377:5-HT 10365:5-HT 10325:5-MT 10239:5-HT 10128:5-HT 9975:5-MT 9967:5-CT 9963:5-BT 9892:mCPP 9814:5-HT 9656:5-MT 9652:5-CT 9648:5-BT 9598:mCPP 9515:5-HT 9410:MPPF 9201:5-MT 9193:5-CT 9094:mCPP 8811:5-HT 8799:5-HT 8414:GPCR 8214:RAIG 8122:GABA 7955:GIPR 7702:CD97 7550:SREB 7351:137B 7326:109B 7321:109A 6751:Zeta 6708:MCHR 6488:NMBR 6483:GRPR 6478:BRS3 6116:EBI2 5982:LTB4 5906:TAAR 5756:5-HT 5418:PMID 5383:PMID 5346:PMID 5317:PMID 5287:PMID 5244:PMID 5207:PMID 5170:PMID 5141:PMID 5103:PMID 5066:PMID 5033:PMID 5004:PMID 4975:PMID 4938:PMID 4909:PMID 4880:PMID 4843:PMID 4806:PMID 4754:for 4712:PMID 4653:PMID 4618:PMID 4569:PMID 4531:PMID 4496:PMID 4447:PMID 4406:PMID 4362:PMID 4321:PMID 4280:PMID 4240:PMID 4196:PMID 4140:PMID 4105:PMID 4053:PMID 4001:PMID 3943:PMID 3902:PMID 3861:PMID 3808:PMID 3755:PMID 3692:PMID 3636:PMID 3601:PMID 3552:PMID 3516:PMID 3465:PMID 3408:PMID 3351:PMID 3315:PMID 3264:PMID 3237:PMID 3202:PMID 3167:PMID 3118:PMID 3083:PMID 3038:2017 3000:PMID 2962:PMID 2900:PMID 2851:PMID 2806:PMID 2762:PMID 2713:PMID 2670:PMID 2621:PMID 2586:PMID 2560:Cell 2533:PMID 2482:PMID 2360:5-HT 2220:and 2189:Type 2171:MPDZ 1977:and 1842:CEPC 1741:mCPP 1719:2C-B 1573:and 1546:and 1523:5-HT 1479:and 1473:ACTH 1463:and 1396:5-HT 1391:TPH2 1312:SNRI 1271:and 1216:and 1201:5-HT 1199:and 1152:5-HT 1145:and 1113:and 1081:5-HT 1055:gene 1004:5-HT 1002:The 713:3358 231:Bgee 179:Band 140:Chr. 74:OMIM 13899:LSD 13475:LSD 13337:LSD 12795:BZP 12279:DPT 12275:DMT 12267:DET 12208:BZP 12119:LSP 12115:LSH 12107:LSD 12103:LSB 12065:DOM 12061:DOI 12057:DOC 12053:DOB 12049:DOx 12018:αMT 12014:αET 11934:2Cs 11606:DPT 11602:DMT 11594:DET 11478:DOM 11474:DOI 11470:DOC 11466:DOB 11462:DOx 10812:DPT 10808:DMT 10800:DET 10755:BZP 10646:LSP 10642:LSH 10634:LSD 10630:LSB 10579:DOM 10575:DOI 10571:DOC 10567:DOB 10563:DOx 10532:αMT 10528:αET 10438:2Cs 9983:DMT 9867:LSD 9660:DMT 9209:DMT 9011:LSD 8426:RTK 8421:Wnt 8208:179 8203:158 8198:156 8194:GPR 7981:GPR 7902:157 7897:155 7892:144 7887:143 7882:133 7877:128 7872:126 7867:125 7862:124 7857:123 7852:116 7847:115 7842:114 7837:113 7832:112 7827:111 7822:110 7798:GPR 7680:EMR 7519:RRH 7514:RGR 7509:1SW 7504:1MW 7499:1LW 7451:183 7446:182 7441:177 7436:176 7431:174 7426:173 7421:171 7416:162 7411:161 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