186:, advises a more cautious approach due to pain's function in protecting individuals from harm. However, Bostrom supports the core idea of using biotechnology to get rid of "a huge amount of unnecessary and undeserved suffering." It has also been argued that the eradication of suffering through biotechnology may bring about unwanted consequences, and arguments have been made that transhumanism is not the only philosophy worthy of consideration regarding the question of suffering — many people view suffering as one aspect in a
1931:
252:
developed a self-exhausting form of CRISPR-based gene drive called a "daisy-chain drive." For potential adverse effects of a gene drive, "everal genetic mechanisms for limiting or eliminating gene drives have been proposed and/or developed, including synthetic resistance, reversal drives, and
70:
was an artificial and harmful intervention in the body's natural response to injury. Opposition to anesthesia has since dissipated; however, the prospect of eradicating pain raises similar concerns about interfering with life's natural functions.
175:(1995), argues that the abolition of suffering is both technically feasible and an issue of moral urgency, stating that: "It is predicted that the world's last unpleasant experience will be a precisely dateable event."
433:
Habib, Abdella M.; Okorokov, Andrei L.; Hill, Matthew N.; Bras, Jose T.; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J.; van
Drimmelen, Marie; Morena, Maria; Houlden, Henry; Ramirez, Juan D. (August 2019).
907:
Noble, Charleston; Min, John; Olejarz, Jason; Buchthal, Joanna; Chavez, Alejandro; Smidler, Andrea L.; DeBenedictis, Erika A.; Church, George M.; Nowak, Martin A.; Esvelt, Kevin M. (2019-04-23).
66:
in the 19th century was an early breakthrough in the elimination of pain during surgery, but acceptance was not universal. Some medical practitioners at the time believed that
110:
A hypothesis is presented to the effect that everything adaptive which is achievable with a mind capable of experiencing varying degrees of both pleasure and pain (the
1425:
652:
82:
have been studied to discover the biological and genetic reasons for their pain-free lives. A Scottish woman with a previously unreported genetic mutation in a
206:
with genetically engineered animals with a reduced or absent capacity to suffer and feel pain. Shriver and McConnachie argued that people who wish to improve
93:
levels was reported in 2019 to be immune to anxiety, unable to experience fear, and insensitive to pain. The frequent burns and cuts she had due to her full
1420:
573:
484:
1763:
1653:
327:
Meyer, Rachel; Desai, Sukumar P. (October 2015). "Accepting pain over comfort: resistance to the use of anesthesia in the mid-19th century".
859:"Compassionate Biology: How CRISPR-based 'gene drives' could cheaply, rapidly and sustainably reduce suffering throughout the living world"
554:
225:
to remove pain and suffering. This would be an intermediate step towards eventually stopping all experimentation on animals and adopting
138:
I imagine what this would be like on another planet and in the future, and... given that imagined future, whether we would be willing to
363:
17:
248:
species. To limit gene drives spreading indefinitely (for test programmes, for example), the
Sculpting Evolution group at the
1646:
436:"Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity"
382:
1178:
1159:
614:
508:
Mancini, L. S. (1990). "Riley-Day
Syndrome, brain stimulation and the genetic engineering of a world without pain".
1415:
1375:
79:
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1072:
226:
1639:
1342:
63:
1975:
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2000:
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People who are naturally incapable of feeling pain or unpleasant sensations due to rare conditions like
1846:
1605:
168:
131:
83:
126:
has raised the prospect that "scientists can identify the causes of certain unusual people's physical
114:
as we know it) could be achieved with a mind capable of experiencing only varying degrees of pleasure.
1697:
1138:
883:
262:
522:
401:
142:. Rather than saying whether we're willing to go forward... ask whether you're willing to come back.
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292:
203:
2005:
1980:
1955:
160:
1995:
1965:
1934:
653:"It's the End of the World as We Know It and We Feel Fantastic: Examining the End of Suffering"
517:
1620:
1508:
1337:
1105:
307:
233:
1801:
106:
published an article by L. S. Mancini on the "genetic engineering of a world without pain":
1896:
1737:
1531:
1013:
920:
595:
574:"FLI Podcast: On the Future of Computation, Synthetic Biology, and Life with George Church"
187:
127:
8:
1780:
1753:
245:
123:
1073:"Red in Tooth and Claw No More: Animal Rights and the Permissibility to Redesign Nature"
1017:
924:
134:
has commented on the potential future of replacing pain with a painless sensory system:
1990:
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531:
465:
409:
344:
1000:
Vella, Michael R.; Gunning, Christian E.; Lloyd, Alun L.; Gould, Fred (2017-09-08).
706:
683:"Knocking Out Pain in Livestock: Can Technology Succeed Where Morality has Stalled?"
1911:
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761:"No Pain, No Gain? In Defence of Genetically Disenhancing (Most) Research Animals"
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364:"Scientists may soon be able to turn off pain with gene editing: should they?"
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237:
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understanding of psychological and physical functioning, without which
90:
86:
67:
722:"Genetically Modifying Livestock for Improved Welfare: A Path Forward"
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47:
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402:"At 71, She's Never Felt Pain or Anxiety. Now Scientists Know Why"
1831:
1329:
909:"Daisy-chain gene drives for the alteration of local populations"
1631:
485:"Scientists find genetic mutation that makes woman feel no pain"
240:
have been suggested as a cost-effective way of spreading benign
241:
27:
Eradicating involuntary pain and suffering using biotechnology
1002:"Evaluating strategies for reversing CRISPR-Cas9 gene drives"
1152:
Chasing Men on Fire: The Story of the Search for a Pain Gene
1231:
43:
221:
Katrien
Devolder and Matthias Eggel proposed gene editing
130:
and use gene editing to grant them to others." Geneticist
633:
1426:
congenital insensitivity to pain with partial anhidrosis
1200:
906:
999:
615:"Should we eliminate the human ability to feel pain?"
555:"The next trick for CRISPR is gene-editing pain away"
432:
202:
In 2009, Adam
Shriver suggested replacing animals in
163:, have debated the merits of eradicating suffering.
719:
1947:
1421:congenital insensitivity to pain with anhidrosis
812:"Animal Rights and the Problem of r-Strategists"
726:Journal of Agricultural and Environmental Ethics
913:Proceedings of the National Academy of Sciences
884:"When Are We Obligated To Edit Wild Creatures?"
1764:Institute for Ethics and Emerging Technologies
1173:. North Carolina: The Neuroethics Foundation.
1647:
1216:
758:
589:
587:
151:Ethicists and philosophers in the schools of
42:to create a permanent absence of involuntary
1070:
856:
759:Devolder, Katrien; Eggel, Matthias (2019).
720:Shriver, Adam; McConnachie, Emilie (2018).
572:Church, George; Perry, Lucas (2020-05-15).
571:
361:
210:should support gene editing in addition to
1654:
1640:
1223:
1209:
1106:"A Kantian ethics of paradise engineering"
1071:Kianpour, Connor; Paez, Eze (2021-02-16).
584:
326:
89:(dubbed FAAH-OUT) with resultant elevated
1043:
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950:
932:
809:
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776:
521:
459:
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552:
146:
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680:
612:
507:
57:
14:
1948:
1168:
1149:
881:
631:
482:
399:
383:"The Family That Feels Almost No Pain"
1635:
1204:
594:Power, Katherine (July–August 2006).
593:
380:
1171:Can Biotechnology Abolish Suffering?
1136:
1103:
362:Hildebrandt, Eleanor (2020-05-19).
24:
1064:
973:
25:
2017:
1661:
816:Ethical Theory and Moral Practice
197:
1930:
1929:
1416:Congenital insensitivity to pain
1376:Paroxysmal extreme pain disorder
1154:. Cambridge, MA: The MIT Press.
1089:10.3197/096327121X16081160834777
553:Regalado, Antonio (2019-08-22).
80:congenital insensitivity to pain
1188:Specter, Michael (2016-12-26).
993:
967:
900:
875:
850:
803:
752:
713:
674:
657:NANO: New American Notes Online
644:
625:
606:
810:Johannsen, Kyle (2017-04-01).
613:Dvorsky, George (2012-09-27).
565:
546:
501:
476:
440:British Journal of Anaesthesia
426:
400:Murphy, Heather (2019-03-28).
393:
374:
355:
320:
64:discovery of modern anesthesia
13:
1:
329:Journal of Anesthesia History
313:
253:immunizing reversal drives."
140:come back to where we are now
97:healed quicker than average.
1837:Nikolai Fyodorovich Fyodorov
1769:Future of Humanity Institute
1190:"Rewriting the Code of Life"
882:Esvelt, Kevin (2019-08-30).
532:10.1016/0306-9877(90)90093-t
184:Future of Humanity Institute
7:
1150:Waxman, Stephen G. (2018).
857:Pearce, David (2016–2020).
634:"The Hedonistic Imperative"
381:Shaer, Matthew (May 2019).
256:
10:
2022:
1137:Levy, Ariel (2020-01-13).
1027:10.1038/s41598-017-10633-2
483:Sample, Ian (2019-03-28).
341:10.1016/j.janh.2015.07.027
1925:
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1307:
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980:Sculpting Evolution Group
828:10.1007/s10677-016-9774-x
738:10.1007/s10806-018-9719-6
699:10.1007/s12152-009-9048-6
651:Renstrom, Joelle (2018).
452:10.1016/j.bja.2019.02.019
173:The Hedonistic Imperative
1703:Eradication of suffering
1682:Transhumanism in fiction
1230:
1104:Paez, Eze (2020-04-01).
578:Future of Life Institute
293:Suffering-focused ethics
38:is the concept of using
1537:Posteromarginal nucleus
1472:Measurement and testing
934:10.1073/pnas.1716358116
161:negative utilitarianism
1781:US Transhumanist Party
1169:Pearce, David (2017).
1139:"A World Without Pain"
681:Shriver, Adam (2009).
632:Pearce, David (1995).
596:"The End of Suffering"
144:
116:
36:abolition of suffering
18:Abolition of suffering
1621:Drug-seeking behavior
1509:Visual analogue scale
1122:10.1093/analys/anz077
976:"Daisy Drive Systems"
559:MIT Technology Review
308:Wild animal suffering
234:wild-animal suffering
147:Ethics and philosophy
136:
108:
1897:Gennady Stolyarov II
1738:Techno-progressivism
1532:Anterolateral system
387:Smithsonian Magazine
246:sexually reproducing
58:Biology and medicine
1976:Genetic engineering
1754:Foresight Institute
1018:2017NatSR...711038V
925:2019PNAS..116.8275N
118:The development of
2001:Concepts in ethics
1802:José Luis Cordeiro
1728:Singularitarianism
1611:Philosophy of pain
1286:Respiratory system
1006:Scientific Reports
778:10.3390/ani9040154
510:Medical Hypotheses
406:The New York Times
278:Effective altruism
182:, director of the
103:Medical Hypotheses
1943:
1942:
1917:Eliezer Yudkowsky
1907:Natasha Vita-More
1887:Martine Rothblatt
1629:
1628:
1484:Cold pressor test
1467:
1466:
1077:White Horse Press
919:(17): 8275–8282.
370:. Leaps by Bayer.
212:plant-based diets
194:could not exist.
16:(Redirected from
2013:
1933:
1932:
1912:Mark Alan Walker
1656:
1649:
1642:
1633:
1632:
1584:Related concepts
1575:Pain eradication
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1320:
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1242:
1239:By region/system
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446:(2): e249–e253.
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359:
353:
352:
324:
268:Appeal to nature
223:research animals
178:The philosopher
122:techniques like
21:
2021:
2020:
2016:
2015:
2014:
2012:
2011:
2010:
1946:
1945:
1944:
1939:
1921:
1892:Anders Sandberg
1862:Ole Martin Moen
1807:K. Eric Drexler
1785:
1742:
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1579:
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1519:Pathophysiology
1513:
1504:Tail flick test
1463:
1432:
1347:
1331:
1318:
1309:Musculoskeletal
1303:
1280:
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1234:
1229:
1181:
1162:
1067:
1065:Further reading
1062:
1061:
998:
994:
985:
983:
982:. MIT Media Lab
974:Esvelt, Kevin.
972:
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523:10.1.1.628.3624
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298:Suffering risks
288:Prioritarianism
283:Pain in animals
259:
236:, CRISPR-based
204:factory farming
200:
149:
112:human condition
60:
52:sentient beings
28:
23:
22:
15:
12:
11:
5:
2019:
2009:
2008:
2006:Utilitarianism
2003:
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1981:Genome editing
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1956:Animal welfare
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1822:Aubrey de Grey
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1733:Technogaianism
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1723:Postpoliticism
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1698:Antinaturalism
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1591:Pain threshold
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1499:Hot plate test
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1366:Pain asymbolia
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1194:The New Yorker
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1143:The New Yorker
1134:
1116:(2): 283–293.
1101:
1083:(2): 211–231.
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992:
966:
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874:
849:
822:(2): 333–345.
802:
751:
732:(2): 161–180.
712:
693:(3): 115–124.
673:
643:
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605:
600:Philosophy Now
583:
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516:(3): 201–207.
500:
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335:(4): 115–121.
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263:Antinaturalism
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208:animal welfare
199:
198:Animal welfare
196:
157:utilitarianism
148:
145:
76:pain asymbolia
59:
56:
26:
9:
6:
4:
3:
2:
2018:
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1996:Transhumanism
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1494:Grimace scale
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1902:Vernor Vinge
1882:David Pearce
1867:Hans Moravec
1857:Ray Kurzweil
1847:James Hughes
1842:Robin Hanson
1817:Ben Goertzel
1797:Nick Bostrom
1773:
1708:Extropianism
1702:
1574:
1406:Phantom pain
1391:Hyperalgesia
1386:Chronic pain
1270:(swallowing)
1268:Odynophagia
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1012:(1): 11038.
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227:alternatives
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167:philosopher
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120:gene editing
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29:
1812:David Gobel
1713:Immortalism
1616:Cancer pain
1542:Substance P
1527:Nociception
1489:Dolorimeter
1444:Pelvic pain
1401:Hyperpathia
1396:Hypoalgesia
1317:Arthralgia
1299:Pleurodynia
1294:Sore throat
687:Neuroethics
238:gene drives
232:Concerning
128:superpowers
95:hypoalgesia
32:eradication
1950:Categories
1677:Transhuman
1565:Anesthesia
1552:Management
1479:Pain scale
1449:Proctalgia
1353:Neurologic
1253:Eye strain
986:2020-06-02
893:2020-06-02
868:2020-06-02
771:(4): 154.
494:2020-05-30
419:2020-05-27
314:References
91:anandamide
87:pseudogene
68:anesthesia
1991:Suffering
1961:Bioethics
1877:Elon Musk
1775:LessWrong
1759:Humanity+
1670:Overviews
1601:Suffering
1570:Cordotomy
1560:Analgesia
1381:Allodynia
1361:Neuralgia
1325:Bone pain
1276:Toothache
1130:0003-2638
1097:234109685
1036:2045-2322
943:0027-8424
844:151950095
836:1572-8447
746:158274840
666:3 January
518:CiteSeerX
414:0362-4331
100:In 1990,
48:suffering
1971:Axiology
1935:Category
1872:Max More
1691:Currents
1606:SOCRATES
1332:(muscle)
1330:Myalgia
1258:Headache
1110:Analysis
1054:28887462
961:30940750
888:leapsmag
797:30970545
707:10504334
470:30929760
368:leapsmag
349:26828088
257:See also
192:pleasure
153:hedonism
1832:FM-2030
1319:(joint)
1045:5591286
1014:Bibcode
952:6486765
921:Bibcode
788:6523187
765:Animals
619:Gizmodo
540:2189064
461:6676009
242:alleles
188:dualist
50:in all
1790:People
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124:CRISPR
1437:Other
1338:Acute
1093:S2CID
840:S2CID
742:S2CID
703:S2CID
602:(56).
171:, in
1986:Pain
1454:Back
1263:Neck
1232:Pain
1175:ISBN
1156:ISBN
1126:ISSN
1050:PMID
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957:PMID
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832:ISSN
793:PMID
668:2022
536:PMID
466:PMID
410:ISSN
345:PMID
214:and
155:and
84:FAAH
62:The
46:and
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30:The
1118:doi
1085:doi
1040:PMC
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