65:
25:
116:
96:, either 'ald' for an aldehyde, or 'ket' for a ketone, in which case it referred to as a 'ketol'. An aldol may also use the term β-hydroxy aldehyde (or β-hydroxy ketone for a ketol). The term "aldol" may refer to
135:
reaction using two aldehydes or an aldehyde and a ketone for a ketol. These reactions may also be done intramolecularly to form 5 or 6 member rings or for stereoselective syntheses in the active area of
328:
Zhang, Yanping; Mu, Hongliang; Pan, Li; Wang, Xuling; Li, Yuesheng (21 May 2018). "Robust Bulky
Neutral Nickel Catalysts for Copolymerization of Ethylene with Polar Vinyl Monomers".
68:
General aldol structure showing the α and 𝛽 positions of carbons relative to the carbonyl. When R" is -H, it is an aldol, when R" is a carbon, it is a ketol.
44:
181:
152:
499:
260:
259:
Kohlpainter, Christian; Schulte, Markus; Falbe, JĂĽrgen; Lappe, Peter; Weber, JĂĽrgen; Frey, Guido D. (15 January 2013).
280:
123:
for chiral aldols. R/S configurations of
127:: A: OH is 4R, R-group is 3R B: OH is 4S, R-group is 3S C: OH is 4R, R-group is 3S D: OH is 4S, R-group is 3R
355:
Schetter, Bernd; Mahrwald, Rainer (2006). "Modern aldol methods for the total synthesis of polyketides".
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Aldols synthesized from two aldehydes are usually unstable, often producing secondary compounds such as
107:-formation reaction, giving them wide applicability as a precursor for a variety of other compounds.
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392:"Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions"
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92:. The name combines the suffix 'ol' from the alcohol and the prefix depending on the
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480:"The Aldol Reaction in Natural Product Synthesis: The Epothilone Story"
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441:"A synthesis of oseltamivir (Tamiflu) starting from D-mannitol"
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Aldols are also used as intermediates in the synthesis of
155:, which can also be used in a variety of other reactions:
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Schinzer, Dieter (2004-06-24), Mahrwald, Rainer (ed.),
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Ko, Ji S.; Keum, Ji E.; Ko, Soo Y. (15 October 2010).
16:Organic compound of the form R–CH(OH)–CHR–C(=O)–R
518:
354:
327:
265:Ullmann's Encyclopedia of Industrial Chemistry
309:National Center for Biotechnology Information
147:in which the hydroxy group is replaced by a
390:Ghosh, Arun K.; Dawson, Zachary L. (2009).
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32:It has been suggested that this article be
110:
467:– via National Library Of Medicine.
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477:
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63:
486:(1 ed.), Wiley, pp. 311–328,
357:Angewandte Chemie International Edition
131:Aldols are usually synthesized from an
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84:(-OH) two carbons away from either an
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151:. The final structure is a reactive
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215:natural products and drugs such as
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204:, which is a precursor to the dye
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348:
292:– via Wiley Online Library.
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153:α,β-unsaturated carbonyl compound
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163:CH(OH)R' → RC(O)CH=CHR' + H
80:is a structure consisting of a
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432:
383:
321:
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1:
344:– via ACS Publications.
273:10.1002/14356007.a01_321.pub3
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121:stereochemical configurations
103:Aldols are the product of a
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55:Proposed since August 2024.
10:
548:
143:Aldols may also undergo a
492:10.1002/9783527619566.ch7
342:10.1021/acscatal.8b01088
192:is a rare example of a
111:Synthesis and reactions
484:Modern Aldol Reactions
408:10.1055/s-0029-1216941
369:10.1002/anie.200602780
261:"Aldehydes, Aliphatic"
128:
69:
182:unsaturated aldehydes
145:condensation reaction
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138:asymmetric synthesis
428:– via Thieme.
206:quinoline Yellow SS
200:is a precursor to
190:Hydroxypivaldehyde
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105:carbon-carbon bond
70:
501:978-3-527-30714-2
457:10.1021/jo101517g
402:(17): 2992–3002.
196:aldol. The aldol
74:organic chemistry
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336:(7): 5963–5976.
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198:3-hydroxybutanal
98:3-hydroxybutanal
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363:(45): 7506–25.
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233:Aldol reactions
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45:Aldol and Ketol
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451:(20): 7006–9.
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305:"CID 21282929"
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133:aldol addition
125:chiral centers
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94:carbonyl group
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39:Hydroxy ketone
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82:hydroxy group
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505:, retrieved
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312:. Retrieved
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286:. Retrieved
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172:Applications
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217:Oseltamivir
194:distillable
521:Categories
507:2024-04-15
445:J Org Chem
314:2023-04-15
239:References
221:Epothilone
213:polyketide
202:quinaldine
527:Aldehydes
396:Synthesis
330:ACS Catal
303:PubChem.
119:Possible
42: to
465:20866058
426:30443084
377:17103481
227:See also
186:alcohols
86:aldehyde
417:6233898
288:1 April
159:RC(O)CH
149:pi bond
50:Discuss
532:Aldols
498:
463:
424:
414:
375:
279:
90:ketone
34:merged
267:(7).
184:, or
178:diols
88:or a
78:aldol
76:, an
36:with
496:ISBN
461:PMID
422:PMID
400:2009
373:PMID
290:2023
277:ISBN
219:and
488:doi
453:doi
412:PMC
404:doi
365:doi
338:doi
269:doi
72:In
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367::
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271::
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165:2
161:2
52:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
