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Ampoule

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128: 2418: 120: 352:. This standard dictates three standardized forms: B, cut/straight-form; C, open-funnel; and D, sealed. (The "A" form is no longer used in the pharmaceutical industry and is not included in the updated version.) ISO 9187-1:2010 addresses what materials should be used in their manufacture, what the dimensions should be, what capacities they should have, how they should perform, and how they should be packaged. Characteristics such as 341: 39: 317: 332:, such as intravenously under hospital care, at greater risk of receiving glass particulates when medication is aspirated. A 2016 study of 180 ampoules found 19,473 glass particles in aspirated fluids, with filtering only reducing the mean by 114 to 89 particles per ampoule. Glass particle contamination of an ampule occurred with all intravenous injection methods. 31: 308:, various silver salts and so on can be packaged in ampoules of smoked glass, glass with chemicals added in manufacturing that filter out ultraviolet and other types of light, or be made with an opaque top and bottom (usually painted with opaque paint) and the rest of the ampoule wrapped in thick paper. 371:
around their necks that are meant to identify the substance inside the ampoule. The rings are machine-readable and allow for accurate handling of the substance for the purposes of storage, labeling, and secondary packaging. Color coding of modern ampoules is done during the manufacturing process. A
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Ampoules are opened by scoring the neck and snapping the top off. In the "one point cut" (OPC) ampoules a dot above the neck identifies the correct thumb placement that aligns the thumb with a pre-made micro-score in the ampoule. If properly done, this last operation creates a clean break without
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The filling and sealing of ampoules may be done by automated machinery on an industrial scale, or by hand in small-scale industries and laboratory. Ampoule-filling machines can be categorized in three categories called automatic machine, semi automatic machine, and manual (hand-operated) machines.
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Glass ampoules are more expensive than bottles and other simple containers, but there are many situations where their superior imperviousness to gases and liquids and all-glass interior surface are worth the extra cost. Examples of chemicals sold in ampoules are
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may be used for sealing under inert atmospheres. This procedure usually involves nitrogen purging before and after filling liquid into ampoules in order to remove atmospheric air available inside the ampoules.
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less than half a week) and special thick-walled quartz and fluorite ampoules under high pressure containing fluorine and chlorine liquefied by the high pressure.
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Ampoules can be pressurized, have air evacuated from them, and have the air in the ampoule replaced with other gasses, often inert ones. The radio-pharmaceutical
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often is packaged in glass ampoules and specially-shaped glass ampoules have long been used for samples of gaseous elements, such as all of the
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by melting the thin top with an open flame, and usually opened by snapping off the neck. The space above the chemical may be filled with an
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Historically, ampoules were used to contain a small sample of a person's blood after death, which was entombed alongside them in many
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Swift, Robert; Schaut, Robert; Flynn, Carol Rea; Asselta, Roger (19 July 2019), Nema, Sandeep; Ludwig, John D. (eds.),
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the metal by rapidly forming a layer of a new inert compound on the metal surface reliably and predictably or at all.
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which is used to contain and preserve a sample, usually a solid or liquid. Ampoules are usually made of glass.
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Blank ampoules can be purchased from scientific glass supply houses and sealed with a small gas torch. A
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Ecology and Behaviour of Free-Ranging Animals Studied by Advanced Data-Logging and Tracking Techniques
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Wassmer, Thomas; Murray, Dennis; Boutin, Stan; Fahlman, Andreas; Jensen, Frants Havmand, eds. (2020).
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any extra glass shards or slivers, but the liquid or solution may be filtered for greater assurance.
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Veal, N. (1 June 1965). "The handling and dispensing of xenon-133: Gas shipments for clinical use".
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were given this burial treatment, though it is suspected to have been a widely practiced tradition.
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An ampere cutter that cuts the neck to open the ampoule. Not required for "one point cut ampoule"
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before sealing. The walls of glass ampoules are usually sufficiently strong to be brought into a
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Glass-particle contamination is of ongoing concern, with patients who receive medication
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The production and packaging of ampoules are largely standardized by ISO 9187-1:2010
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Containment Technology: Progress in the Pharmaceutical and Food Processing Industry.
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ampoules have been developed, based on the concept of the Teflon jug for high-
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and chemicals that must be protected from air and contaminants. They are
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Viaggio nelle catacombe di Roma di un membro dell'Accademia di Cortona
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Injection equipment for medical use — Part 1: Ampoules for injectables
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Modern glass ampoules are produced industrially from short lengths of
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Joo, Ga Eul; Sohng, Kyeong-Yae; Park, Michael Yong (6 January 2016).
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machine applies colored rings on the ampoule between the two ovens.
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Photosensitive chemicals like many 14-dihydromorphinone opioids like
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An ampoule allegedly dating back to the year 305 and filled with the
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A large ampoule containing 1.4 kg (3.1 lb) of high-purity
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International Organization for Standardization (October 2010).
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monarchs. The oil was allegedly passed down from the time of
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Ampoules are common practice as containers of low-frequency
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The International Journal of Applied Radiation and Isotopes
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Pages displaying wikidata descriptions as a fallback
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Diagram of an ampoule showing color-coded neck rings
525:"Glass particle contamination: is it here to stay?" 506:"The acid that really does eat through everything" 68:Modern ampoules are most commonly used to contain 2435: 677:. International Organization for Standardization 873:Modified atmosphere/modified humidity packaging 821: 791:Hans-Jürgen Bässler und Frank Lehmann : 571: 2007:Hazard analysis and critical control points 634:(4 ed.), CRC Press, pp. 425–450, 244:and gravity in automated production lines. 34:Ampoules containing pharmaceutical products 828: 814: 720: 718: 628:"Glass Containers for Parenteral Products" 1917:Automatic identification and data capture 762: 599: 589: 540: 523:Lye, S. T.; Hwang, N. C. (January 2003). 396: – small vessel used in ancient Rome 276:(mainly because it is radioactive with a 522: 436: 339: 315: 216:; it was kept for a time in the tomb of 151:. It was originally believed that only 126: 118: 97:tetrakis(triphenylphosphine)palladium(0) 37: 29: 715: 14: 2436: 809: 363:Ampoules often have colored rings of 174:, has been kept for centuries in the 1319:Flexible intermediate bulk container 668: 666: 621: 619: 455: 248:techniques are usually employed for 360:are specified for all three forms. 24: 2303:Vertical form fill sealing machine 785: 189:Another well-known ampoule is the 25: 2465: 2273:Rotary wheel blow molding systems 1121:Purdue Improved Crop Storage bags 663: 616: 542:10.1046/j.1365-2044.2003.296812.x 2417: 2416: 2243:Mechanical brake stretch wrapper 123:A collection of ancient ampoules 114: 1977:Electronic article surveillance 1831:Shock and vibration data logger 1676:Linear low-density polyethylene 744: 689: 2082:Radio-frequency identification 565: 516: 498: 484: 449: 430: 410: 222:Cathedral of Notre-Dame, Reims 95:, air-sensitive reagents like 27:Hermetically-sealed glass vial 13: 1: 2193:Extended core stretch wrapper 1146:Single-serve coffee container 835: 427:, Milano, G. Silvestri, 1835. 403: 375: 356:, hydrolytic resistance, and 231: 109:trifluoromethanesulfonic acid 1349:Insulated shipping container 470:10.1016/0020-708X(65)90023-2 335: 111:, and analytical standards. 7: 2449:Medicine storage containers 2238:Material-handling equipment 2122:Verification and validation 1354:Intermediate bulk container 1136:Self-heating food packaging 387: 10: 2470: 1881:Time temperature indicator 437:Thurston, Herbert (1910). 2414: 2336:Environmental engineering 2311: 2298:Turntable stretch wrapper 2228:Lineshaft roller conveyor 2218:Injection molding machine 2130: 1899: 1529: 1174: 1156:Toothpaste pump dispenser 1016:Disposable food packaging 961: 858:Child-resistant packaging 843: 764:10.3389/978-2-88963-792-8 591:10.1186/s40064-015-1632-0 240:, shaped by heating with 2223:Label printer applicator 2092:Shearing (manufacturing) 1691:Low-density polyethylene 1111:Pharmaceutical packaging 1081:Low plastic water bottle 971:Alternative wine closure 640:10.1201/9780429201400-25 311: 84:without any difficulty. 2454:Single-serve containers 2253:Orbital stretch wrapper 1876:Temperature data logger 1796:Pressure-sensitive tape 1656:Humidity indicator card 1184:Aerosol spray dispenser 795:Springer, Berlin 2013, 226:coronation of Charles X 1972:Die forming (plastics) 1681:Liquid packaging board 1384:Multilayered packaging 1116:Plastic milk container 1096:Optical disc packaging 632:Parenteral Medications 345: 321: 144: 124: 46: 35: 2401:Sustainable packaging 2351:Life-cycle assessment 2331:Closed-loop box reuse 2278:Seed-counting machine 1611:Corrugated fiberboard 1561:Biodegradable plastic 1284:Corrugated box design 938:Sustainable packaging 928:Shelf-ready packaging 903:Packaging engineering 697:"Let's make ampoules" 443:Catholic Encyclopedia 343: 319: 224:. It was used at the 130: 122: 61:) is a small sealed 41: 33: 2371:PET bottle recycling 2233:Logistics automation 1761:Plastic-coated paper 908:Resealable packaging 419:Seroux d'Agincourt, 184:Feast of San Gennaro 2423:Category: Packaging 2258:Packaging machinery 2067:Product development 1866:Tamper-evident band 1706:Modified atmosphere 1046:Foam food container 510:the chronicle flask 149:Christian catacombs 105:deuterated solvents 74:hermetically sealed 2386:Reusable packaging 2346:Industrial ecology 2107:Ultrasonic welding 2072:Production control 2022:Injection moulding 1907:Aseptic processing 1616:Corrugated plastic 1486:Steel and tin cans 1456:Shipping container 1394:Packet (container) 1131:Seasonal packaging 1031:Evidence packaging 1011:Currency packaging 1006:Cosmetic packaging 913:Reusable packaging 346: 322: 145: 125: 47: 36: 2429: 2428: 2391:Reverse logistics 2376:Plastic recycling 2248:Multihead weigher 2168:Cartoning machine 2163:Cap torque tester 2077:Quality assurance 2052:Plastic extrusion 2017:Induction sealing 1987:Extrusion coating 1846:Staple (fastener) 1816:Security printing 1651:Hot-melt adhesive 1224:Biodegradable bag 1066:Glass milk bottle 948:Tamper resistance 888:Package pilferage 863:Contract packager 649:978-0-429-20140-0 439:"Saint Januarius" 358:annealing quality 291:hydrofluoric acid 220:and later in the 197:) which held the 16:(Redirected from 2461: 2420: 2419: 2406:Waste management 2396:Source reduction 2213:Industrial robot 2117:Vacuum packaging 2042:Package tracking 1997:Glass production 1957:Corona treatment 1947:Containerization 1811:Screw cap (wine) 1726:Oxygen scavenger 1189:Aluminium bottle 1141:Screw cap (wine) 1086:Luxury packaging 918:Reuse of bottles 883:Package delivery 868:Edible packaging 853:Active packaging 830: 823: 816: 807: 806: 779: 778: 766: 748: 742: 741: 739: 737: 732:on 12 March 2013 728:. 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896: 894: 891: 889: 886: 884: 881: 879: 878:Overpackaging 876: 874: 871: 869: 866: 864: 861: 859: 856: 854: 851: 850: 848: 842: 838: 831: 826: 824: 819: 817: 812: 811: 808: 802: 798: 794: 790: 789: 776: 770: 765: 760: 756: 755: 747: 731: 727: 721: 719: 702: 698: 692: 676: 669: 667: 659: 655: 651: 645: 641: 637: 633: 629: 622: 620: 611: 607: 602: 597: 592: 587: 583: 579: 575: 568: 560: 556: 552: 548: 543: 538: 534: 530: 526: 519: 511: 507: 501: 493: 487: 479: 475: 471: 467: 463: 459: 452: 444: 440: 433: 426: 422: 413: 409: 395: 392: 391: 385: 383: 373: 370: 366: 361: 359: 355: 351: 342: 333: 331: 326: 318: 309: 307: 303: 302:hydromorphone 298: 296: 292: 289: 285: 281: 279: 275: 271: 267: 262: 259: 253: 251: 247: 243: 239: 229: 227: 223: 219: 215: 211: 207: 203: 200: 196: 192: 187: 185: 181: 177: 173: 170:), bishop of 169: 165: 161: 156: 154: 150: 142: 138: 134: 129: 121: 115:Early history 112: 110: 106: 102: 98: 94: 91: 85: 83: 79: 75: 71: 66: 64: 60: 56: 52: 45: 40: 32: 19: 2444:Dosage forms 2431: 2312:Environment, 1927:Blow molding 1856:Stretch wrap 1786:Polyethylene 1776:Plastic wrap 1766:Plastic film 1751:Paper pallet 1686:Living hinge 1591:Coated paper 1471:Spray bottle 1451:Security bag 1444:Water sachet 1434:Salvage drum 1429:Retort pouch 1334:Glass bottle 1229:Blister pack 1198: 1194:Aluminum can 1161:Water bottle 1061:Gas cylinder 1036:Field ration 933:Shelf-stable 792: 753: 746: 734:. Retrieved 730:the original 705:. Retrieved 700: 691: 679:. Retrieved 631: 581: 578:SpringerPlus 577: 567: 535:(1): 93–94. 532: 528: 518: 509: 500: 486: 461: 457: 451: 442: 432: 420: 417:(in Italian) 412: 379: 362: 349: 347: 330:parenterally 327: 323: 299: 282: 263: 258:Schlenk line 254: 238:glass tubing 235: 194: 191:Holy Ampulla 188: 167: 157: 146: 137:Holy Ampulla 86: 67: 58: 54: 50: 48: 2208:Heat sealer 2173:Case sealer 2047:Papermaking 1967:Die cutting 1932:Calendering 1836:Shrink wrap 1711:Molded pulp 1696:Meat diaper 1661:Kraft paper 1641:Foam peanut 1631:Double seam 1601:Coextrusion 1571:Bubble wrap 1551:Bail handle 1496:Thermal bag 1419:Plastic bag 1234:Boil-in-bag 1166:Wine bottle 1151:Spray paint 1106:Popcorn bag 1101:Oyster pail 986:Beer bottle 736:14 February 529:Anaesthesia 306:oxymorphone 270:noble gases 242:gas torches 168:San Gennaro 143:of Clovis I 135:brings the 101:hygroscopic 2438:Categories 2288:Staple gun 2268:Palletizer 2158:Can seamer 2027:Lamination 1952:Converting 1841:Slip sheet 1756:Paperboard 1621:Cushioning 1581:Cellophane 1556:Bioplastic 1534:components 1521:Wooden box 1491:Tetra Brik 1414:Paper sack 1389:Multi-pack 1339:Gunny sack 1209:Bag-in-box 1176:Containers 1041:Flour sack 1026:Egg carton 1001:Coffee bag 981:Banana box 923:Shelf life 701:Making.com 404:References 376:Other uses 232:Production 206:coronation 133:Holy Ghost 90:injectable 2381:Recycling 2188:Drum pump 2131:Machinery 1982:Extrusion 1900:Processes 1871:Tear tape 1861:Susceptor 1851:Strapping 1806:Screw cap 1781:Polyester 1626:Desiccant 1530:Materials 1511:Unit load 1466:Skin pack 1409:Paper bag 1279:Clamshell 1021:Drink can 953:Wrap rage 837:Packaging 658:200544220 425:pp. 200-1 382:RFID tags 336:Standards 295:passivate 278:half-life 266:Xenon-133 228:in 1825. 199:anointing 176:Cathedral 172:Benevento 78:inert gas 2314:post-use 2203:Heat gun 2153:Calender 2062:Printing 1891:Velostat 1886:Tinplate 1721:Overwrap 1646:Gel pack 1636:Flip-top 1541:Adhesive 1476:Squround 1379:Mesh bag 1364:Jerrycan 1309:Envelope 1249:Bulk box 1126:Sand bag 1091:Milk bag 1076:Juicebox 991:Box wine 964:packages 610:26759754 559:41073335 551:12492680 478:14327645 423:(1810), 388:See also 288:molarity 214:Clovis I 204:for the 139:for the 82:glovebox 2037:Molding 1942:Coating 1937:Canning 1596:Coating 1586:Closure 1344:Inhaler 1199:Ampoule 1071:Growler 962:Product 844:General 707:15 June 681:15 June 601:4703599 394:Ampulla 208:of the 153:martyrs 141:baptism 51:ampoule 44:caesium 2421:  2356:Litter 2198:Filler 1741:Pallet 1439:Sachet 1304:Endcap 1269:Carton 1264:Carboy 1239:Bottle 1219:Barrel 846:topics 799:  771:  656:  646:  608:  598:  584:: 15. 557:  549:  476:  369:enamel 284:Teflon 210:French 180:Naples 59:ampule 53:(also 18:Ampule 1746:Paper 1666:Label 1566:BoPET 1289:Crate 654:S2CID 555:S2CID 365:paint 312:Usage 274:radon 272:save 160:blood 55:ampul 1576:Bung 1516:Vial 1506:Tube 1404:Pail 1299:Drum 1274:Chub 1259:Case 1254:Cage 797:ISBN 769:ISBN 738:2013 709:2022 683:2022 644:ISBN 606:PMID 547:PMID 474:PMID 304:and 131:The 107:and 63:vial 57:and 1671:Lid 1532:and 1374:Keg 1369:Jug 1359:Jar 1244:Box 1214:Bag 759:doi 636:doi 596:PMC 586:doi 537:doi 466:doi 367:or 202:oil 178:at 162:of 49:An 2440:: 767:. 717:^ 699:. 665:^ 652:, 642:, 630:, 618:^ 604:. 594:. 580:. 576:. 553:. 545:. 533:58 531:. 527:. 508:. 472:. 462:16 460:. 441:. 252:. 99:, 829:e 822:t 815:v 777:. 761:: 740:. 711:. 685:. 638:: 612:. 588:: 582:5 561:. 539:: 494:. 480:. 468:: 445:. 193:( 166:( 20:)

Index

Ampule


caesium
vial
pharmaceuticals
hermetically sealed
inert gas
glovebox
injectable
pharmaceuticals
tetrakis(triphenylphosphine)palladium(0)
hygroscopic
deuterated solvents
trifluoromethanesulfonic acid


Holy Ghost
Holy Ampulla
baptism
Christian catacombs
martyrs
blood
Saint Januarius
Benevento
Cathedral
Naples
Feast of San Gennaro
Holy Ampulla
anointing

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