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435:, which promotes and carries out research on ALD and other similar disorders. Michaela also insisted on continuing to treat her incapacitated son as a human being and not a "vegetable", helping him devise a means of communicating with her and others through the blinking of his eyes and the wiggling of his fingers.
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in 1923. Lorenzo was diagnosed in April 1984, using a new blood test that had been recently developed. At the time, people diagnosed with the disease were usually young boys between 5 and 10 years old, who would gradually become mute, deaf, blind and paralysed before dying, which typically happened
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Lorenzo died the day after his 30th birthday. He was almost totally paralyzed but was, according to his father
Augusto, "holding his own". He was unable to speak or move on his own. He communicated by wiggling his fingers and blinking his eyes. His mind was intact and he enjoyed music and having
424:, and through long hours of research and study, the Odones, who had had no previous medical background, came up with a treatment. This treatment involved the consumption of a specially prepared oil, which became known as "
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In truth, Hugo, who diagnosed
Lorenzo back in 1984 as suffering with ALD, was too intellectually curious to dismiss Lorenzo's oil simply because it was the finding of two lay people
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Aubourg P, Adamsbaum C, Lavallard-Rousseau MC, Rocchiccioli F, Cartier N, Jambaqué I, Jakobezak C, Lemaitre A, Boureau F, Wolf C (September 1993).
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entitled "Dr. Jay", in which the main character Jay
Sherman works to discover a cure for his boss' terminal disease, was a parody of the story.
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as final, and fought to find a treatment for the disease, often conflicting with doctors, specialist and support groups. With the help of
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people read to him. He lived with his father in
Virginia and was cared for by nurses and his family friend, Oumouri Hassane.
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510:"Lorenzo Odone Subject of Lorenzo's Oil, the film portraying his parents' quest to cure his degenerative disease"
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until his death. Michaela Odone battled lung cancer for some time and died on June 10, 2000, at the age of 61.
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Vedantam, Shankar. "A Real-Life Sequel to 'Lorenzo's Oil'; After His Death, Scientist's Work May Bear Fruit."
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737:"A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy"
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In mid-2010, two years after
Lorenzo's death, Augusto Odone sold his home in Virginia and moved to
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Siemerling E, Creutzfeldt HG (1923). "Bronzekrankheit und sklerosierende
Encephalomyelitis".
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In recognition of the parents' work, Augusto Odone received an honorary doctorate from the
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where he lived when he was young. He died there on 24 October 2013, at the age of 80.
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The Odones had an important role in developing
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The Odones' story was first depicted in the 1990 Italian television film
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for their son's incurable illness. This quest was recounted in the film
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This severe form of adrenoleukodystrophy was first described by
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within two years due to aspiration or neurological causes.
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366:(1992). Augusto had previously been an economist for the
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A poem
Michaela wrote about Lorenzo was set to music by
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Odone A, Odone M (June 1994). "More on
Lorenzo's oil".
348:(January 10, 1939 – June 10, 2000) were the parents of
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563:"Michaela Odone, 61, the 'Lorenzo's Oil' Mother Dies"
62:. Unsourced material may be challenged and removed.
392:in his native Italy, near his father's village of
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416:Augusto and Michaela refused to accept this
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352:(May 29, 1978 – May 30, 2008), who had
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457:. It was later made into the 1992 film
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71:"Augusto, Michaela, and Lorenzo Odone"
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889:Find A Grave: Michaela Odone
350:Lorenzo Michael Murphy Odone
346:Michaela Teresa Murphy Odone
289:Lorenzo Michael Murphy Odone
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894:Find A Grave: Lorenzo Odone
884:Find A Grave: Augusto Odone
756:10.1056/NEJM199309093291101
714:10.1056/NEJM199406303302615
636:Arch. Psychiat. Neurokrankh
617:"Obituaries: Augusto Odone"
591:"Obituaries: Lorenzo Odone"
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27:Parents of Lorenzo Odone
847:"ALD and Lorenzo's Oil"
837:Describes the death of
808:June 13, 2008, at the
778:Augusto Odone (2011).
375:University of Stirling
224:Michaela Teresa Murphy
824:Remembering Michaela
490:Dance into the Light
474:The 1994 episode of
354:adrenoleukodystrophy
342:Augusto Daniel Odone
333:Adrenoleukodystrophy
147:Augusto Daniel Odone
56:improve this article
873:. January 28, 2007.
871:The Washington Post
782:. Mondadori, 2011.
676:. February 21, 2007
439:Cultural depictions
830:The Myelin Project
648:10.1007/BF01835678
567:The New York Times
433:The Myelin Project
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49:verification
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839:Hugo Moser
497:References
477:The Critic
465:Nick Nolte
422:Hugo Moser
400:Background
368:World Bank
294:1978-05-29
229:1939-01-10
191:Occupation
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82:newspapers
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194:Economist
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