408:
385:
307:
282:
659:
666:
31:
414:
313:
2941:
1676:
Bim expression and activity are regulated at the transcriptional, translational and post-translational levels; coordinated expression and activity of Bim shape immune responses, and ensure tissue integrity. Cancer cells develop mechanisms that suppress Bim expression, which allows for tumor
57:
1643:
regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including
421:
320:
1664:), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in
2446:
Bouillet P, Metcalf D, Huang DC, et al. (1999). "Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity".
1839:"BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members"
2526:
Bouillet P, Zhang LC, Huang DC, et al. (2001). "Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim".
2801:
Liu JW, Chandra D, Tang SH, et al. (2002). "Identification and characterization of
Bimgamma, a novel proapoptotic BH3-only splice variant of Bim".
1154:
1135:
243:
2606:
Murray S, Halford S, Ebenezer ND, et al. (2001). "Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids".
2413:"A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region"
2721:
Bouillet P, Purton JF, Godfrey DI, et al. (2002). "BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes".
1810:
1792:
2170:"MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain"
2043:
Whitfield J, Harada K, Bardelle C, Staddon JM (November 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins".
54:
2907:
1542:
1549:
1934:
3010:
2986:
2919:
2335:"The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4"
1775:
3005:
1754:
2004:"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function"
2680:"Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family"
2292:"Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)"
2378:"The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex"
407:
2477:"Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1"
2127:
Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den
Hollander P, Kumar R (June 2004).
2002:
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005).
2760:"Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis"
1779:
1758:
384:
1199:
2645:"BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis"
1180:
960:
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
306:
281:
223:
1668:-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
420:
319:
1686:
413:
312:
2979:
2129:"Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes"
2867:"Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim"
2078:
Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG (February 2004).
2565:"Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis"
1525:
1521:
1517:
1513:
1509:
1487:
1483:
1428:
1424:
1420:
1410:
1406:
1402:
1398:
1394:
1362:
1358:
1297:
1293:
1289:
1279:
1275:
1271:
1267:
1263:
231:
210:
845:
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
1499:
1495:
1491:
1468:
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1374:
1370:
1366:
1337:
1333:
1329:
1325:
1321:
1317:
1313:
1309:
1305:
1301:
1885:
O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC (February 1998).
251:
2972:
2488:
295:
8:
2925:
2913:
1657:
940:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
2492:
1639:
protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-
970:
positive regulation of mitochondrial membrane permeability involved in apoptotic process
2853:
2746:
2709:
2631:
2594:
2551:
2514:
2359:
2334:
2321:
2104:
2079:
1974:
1949:
1911:
1886:
1693:
255:
2840:
2823:
2784:
2759:
2696:
2679:
2661:
2644:
2581:
2564:
2501:
2476:
2394:
2377:
2308:
2291:
1656:, and to act as an apoptotic activator. The expression of this gene can be induced by
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
727:
722:
717:
712:
707:
2888:
2845:
2810:
2789:
2775:
2738:
2701:
2666:
2623:
2586:
2543:
2506:
2463:
2434:
2399:
2364:
2313:
2278:
2232:
2191:
2150:
2109:
2060:
2025:
1979:
1916:
1860:
1050:
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
203:
47:
2857:
2713:
2635:
2598:
2518:
235:
2878:
2835:
2779:
2771:
2750:
2730:
2691:
2656:
2615:
2576:
2555:
2535:
2496:
2455:
2424:
2389:
2354:
2346:
2303:
2268:
2222:
2181:
2140:
2099:
2091:
2052:
2015:
1969:
1961:
1906:
1898:
1850:
500:
431:
375:
330:
2459:
2325:
2960:
2020:
2003:
475:
259:
1815:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1797:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1030:
activation of cysteine-type endopeptidase activity involved in apoptotic process
658:
2956:
2824:"Direct addition of BimL to mitochondria does not lead to cytochrome c release"
576:
2350:
2227:
2210:
2145:
2128:
665:
2999:
2080:"Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands"
2056:
1965:
1902:
694:
636:
514:
2952:
2892:
2883:
2866:
2849:
2814:
2793:
2742:
2705:
2670:
2627:
2590:
2547:
2510:
2467:
2438:
2429:
2412:
2403:
2273:
2256:
2236:
2195:
2186:
2169:
2154:
2113:
2064:
2029:
1983:
1855:
1838:
1636:
493:
272:
30:
2539:
2368:
2317:
2282:
1920:
1864:
1589:
1584:
1244:
1225:
1884:
2126:
2095:
392:
289:
239:
2619:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
2209:
Heckmeier PJ, Ruf J, Buhrke D, Janković BG, Hamm P (September 2022).
1665:
1640:
1099:
459:
446:
358:
345:
247:
2734:
1573:
2821:
1887:"Bim: a novel member of the Bcl-2 family that promotes apoptosis"
1617:
1211:
1166:
1084:
1080:
1660:(NGF), as well as by the forkhead transcription factor FKHR-L1 (
1010:
positive regulation of release of cytochrome c from mitochondria
674:
227:
1711:
1699:
1649:
1557:
1121:
985:
intrinsic apoptotic signaling pathway in response to DNA damage
2042:
935:
positive regulation of IRE1-mediated unfolded protein response
1730:
1705:
1661:
2375:
1035:
positive regulation of intrinsic apoptotic signaling pathway
2948:
2940:
2822:
Terradillos O, Montessuit S, Huang DC, Martinou JC (2002).
1935:"Entrez Gene: BCL2L11 BCL2-like 11 (apoptosis facilitator)"
1717:
1653:
1645:
1624:
1055:
positive regulation of autophagy in response to ER overload
1040:
apoptotic process involved in embryonic digit morphogenesis
2376:
Puthalakath H, Huang DC, O'Reilly LA, et al. (1999).
2208:
2077:
990:
extrinsic apoptotic signaling pathway in absence of ligand
2211:"Signal Propagation Within the MCL-1/BIM Protein Complex"
483:
2865:
Sugiyama T, Shimizu S, Matsuoka Y, et al. (2002).
2864:
2475:
Dijkers PF, Medema RH, Lammers JW, et al. (2000).
1947:
2563:
Putcha GV, Moulder KL, Golden JP, et al. (2001).
2720:
2605:
648:
2678:
Mami U, Miyashita T, Shikama Y, et al. (2002).
2677:
2474:
2445:
2562:
1000:
positive regulation of fibroblast apoptotic process
2758:Marani M, Tenev T, Hancock D, et al. (2002).
2757:
2525:
2411:Ohi N, Tokunaga A, Tsunoda H, et al. (1999).
2410:
2001:
1771:
1769:
1767:
1750:
1748:
1746:
830:positive regulation of protein homooligomerization
870:positive regulation of apoptotic process by virus
430:
329:
2997:
2643:Cheng EH, Wei MC, Weiler S, et al. (2001).
1635:The protein encoded by this gene belongs to the
2168:Bae J, Leo CP, Hsu SY, Hsueh AJ (August 2000).
1764:
1743:
955:positive regulation of neuron apoptotic process
16:Protein-coding gene in the species Homo sapiens
2800:
2642:
2332:
2167:
1997:
1995:
1993:
1776:GRCm38: Ensembl release 89: ENSMUSG00000027381
2980:
2290:Zha J, Harada H, Yang E, et al. (1997).
2289:
2255:Wang K, Yin XM, Chao DT, et al. (1996).
1880:
1878:
1876:
1874:
1832:
1830:
1828:
1826:
1824:
2257:"BID: a novel BH3 domain-only death agonist"
2161:
2120:
2071:
2036:
1948:Sionov RV, Vlahopoulos SA, Granot Z (2015).
1060:cellular response to glucocorticoid stimulus
2254:
1990:
1941:
1836:
1755:GRCh38: Ensembl release 89: ENSG00000153094
2987:
2973:
1871:
1821:
587:transitional epithelium of urinary bladder
2882:
2839:
2783:
2695:
2660:
2580:
2500:
2428:
2393:
2358:
2307:
2272:
2226:
2185:
2144:
2103:
2019:
1973:
1950:"Regulation of Bim in Health and Disease"
1910:
1854:
1837:Hsu SY, Lin P, Hsueh AJ (November 1998).
880:post-embryonic animal organ morphogenesis
1015:regulation of developmental pigmentation
995:positive regulation of apoptotic process
930:odontogenesis of dentin-containing tooth
915:response to endoplasmic reticulum stress
759:intracellular membrane-bounded organelle
1065:cellular response to estradiol stimulus
2998:
435:
396:
391:
334:
293:
288:
2935:
1671:
623:endothelial cell of lymphatic vessel
591:vestibular membrane of cochlear duct
2333:Huang DC, Adams JM, Cory S (1998).
723:protein heterodimerization activity
13:
2247:
14:
3022:
2901:
1620:that in humans is encoded by the
1070:cellular response to amyloid-beta
965:positive regulation of cell cycle
840:positive regulation of cell death
2939:
2776:10.1128/MCB.22.11.3577-3589.2002
664:
657:
419:
412:
406:
383:
318:
311:
305:
280:
29:
2202:
1680:
825:regulation of apoptotic process
799:extrinsic component of membrane
1927:
1803:
1785:
890:in utero embryonic development
675:More reference expression data
637:More reference expression data
1:
3011:Human chromosome 2 gene stubs
2841:10.1016/S0014-5793(02)02871-5
2697:10.1016/S0014-5793(01)03145-3
2662:10.1016/S1097-2765(01)00320-3
2582:10.1016/S0896-6273(01)00238-0
2502:10.1016/S0960-9822(00)00728-4
2460:10.1126/science.286.5445.1735
2395:10.1016/S1097-2765(00)80456-6
2309:10.1016/S0092-8674(00)81382-3
1736:
1616:ediator of cell death), is a
404:
303:
214:, BAM, BIM, BOD, BCL2 like 11
2959:. You can help Knowledge by
2215:Journal of Molecular Biology
2021:10.1016/j.molcel.2004.12.030
1677:progression and metastasis.
804:Bcl-2 family protein complex
769:mitochondrial outer membrane
7:
3006:Genes on human chromosome 2
2912:human gene location in the
1724:
1630:
905:thymocyte apoptotic process
541:superficial temporal artery
10:
3027:
2934:
2924:human gene details in the
1685:BCL2L11 has been shown to
1025:regulation of organ growth
1005:developmental pigmentation
910:post-embryonic development
779:cytoplasmic dynein complex
603:retinal pigment epithelium
2228:10.1016/j.jmb.2022.167499
2146:10.1016/j.ccr.2004.05.022
1811:"Mouse PubMed Reference:"
1793:"Human PubMed Reference:"
1588:
1583:
1579:
1572:
1556:
1543:Chr 2: 111.12 – 111.17 Mb
1537:
1506:
1482:
1417:
1393:
1386:
1355:
1351:
1286:
1262:
1255:
1242:
1238:
1223:
1219:
1210:
1197:
1193:
1178:
1174:
1165:
1152:
1148:
1133:
1129:
1120:
1105:
1098:
1094:
1078:
920:mammary gland development
693:
689:
672:
656:
647:
634:
583:
574:
537:mucosa of paranasal sinus
533:epithelium of nasopharynx
521:
512:
482:
474:
470:
453:
440:
403:
382:
373:
369:
352:
339:
302:
279:
270:
266:
221:
218:
208:
201:
196:
73:
68:
51:
46:
41:
37:
28:
23:
2057:10.1016/j.ab.2003.07.014
1966:10.18632/oncotarget.5492
875:myeloid cell homeostasis
850:B cell apoptotic process
611:Rostral migratory stream
2351:10.1093/emboj/17.4.1029
1604:, commonly called BIM (
615:external carotid artery
599:internal carotid artery
557:mucosa of sigmoid colon
2884:10.1038/sj.onc.1205621
2430:10.1038/sj.cdd.4400493
2274:10.1101/gad.10.22.2859
2187:10.1074/jbc.M909826199
1903:10.1093/emboj/17.2.384
1856:10.1210/mend.12.9.0166
1550:Chr 2: 127.97 – 128 Mb
865:lymphocyte homeostasis
835:male gonad development
728:protein kinase binding
718:dynein complex binding
2608:Cytogenet. Cell Genet
2540:10.1007/s003350010242
1602:Bcl-2-like protein 11
820:leukocyte homeostasis
529:palpebral conjunctiva
1020:cell-matrix adhesion
398:Chromosome 2 (mouse)
296:Chromosome 2 (human)
69:List of PDB id codes
42:Available structures
2926:UCSC Genome Browser
2914:UCSC Genome Browser
2493:2000CBio...10.1201D
1658:nerve growth factor
794:endomembrane system
713:microtubule binding
545:gingival epithelium
260:BCL2L11 - orthologs
2947:This article on a
2096:10.1042/BJ20031251
1200:ENSMUSG00000027381
925:T cell homeostasis
900:spleen development
895:B cell homeostasis
860:thymus development
855:kidney development
813:Biological process
774:BIM-BCL-xl complex
737:Cellular component
701:Molecular function
2968:
2967:
2620:10.1159/000056930
2417:Cell Death Differ
2090:(Pt 3): 597–605.
1960:(27): 23058–134.
1672:Regulation of Bim
1599:
1598:
1595:
1594:
1568:
1567:
1533:
1532:
1476:
1475:
1382:
1381:
1345:
1344:
1251:
1250:
1232:
1231:
1206:
1205:
1187:
1186:
1161:
1160:
1142:
1141:
1090:
1089:
1045:apoptotic process
950:brain development
764:BIM-BCL-2 complex
685:
684:
681:
680:
643:
642:
630:
629:
568:
567:
466:
465:
365:
364:
192:
191:
188:
187:
52:Ortholog search:
3018:
2989:
2982:
2975:
2943:
2936:
2896:
2886:
2861:
2843:
2818:
2797:
2787:
2754:
2717:
2699:
2674:
2664:
2639:
2602:
2584:
2559:
2522:
2504:
2471:
2454:(5445): 1735–8.
2442:
2432:
2407:
2397:
2372:
2362:
2329:
2311:
2286:
2276:
2241:
2240:
2230:
2206:
2200:
2199:
2189:
2180:(33): 25255–61.
2165:
2159:
2158:
2148:
2124:
2118:
2117:
2107:
2075:
2069:
2068:
2040:
2034:
2033:
2023:
1999:
1988:
1987:
1977:
1945:
1939:
1938:
1931:
1925:
1924:
1914:
1882:
1869:
1868:
1858:
1834:
1819:
1818:
1807:
1801:
1800:
1789:
1783:
1773:
1762:
1752:
1581:
1580:
1552:
1545:
1528:
1480:
1479:
1471:
1391:
1390:
1387:RefSeq (protein)
1377:
1349:
1348:
1340:
1260:
1259:
1236:
1235:
1217:
1216:
1191:
1190:
1172:
1171:
1146:
1145:
1127:
1126:
1096:
1095:
691:
690:
677:
668:
661:
654:
653:
639:
579:
577:Top expressed in
572:
571:
517:
515:Top expressed in
510:
509:
489:
488:
472:
471:
462:
449:
438:
423:
416:
410:
399:
387:
371:
370:
361:
348:
337:
322:
315:
309:
298:
284:
268:
267:
262:
213:
206:
183:
66:
65:
60:
39:
38:
33:
21:
20:
3026:
3025:
3021:
3020:
3019:
3017:
3016:
3015:
2996:
2995:
2994:
2993:
2932:
2904:
2899:
2877:(32): 4944–56.
2809:(10): 2976–81.
2770:(11): 3577–89.
2764:Mol. Cell. Biol
2735:10.1038/415922a
2729:(6874): 922–6.
2267:(22): 2859–69.
2250:
2248:Further reading
2245:
2244:
2207:
2203:
2166:
2162:
2125:
2121:
2076:
2072:
2041:
2037:
2000:
1991:
1946:
1942:
1933:
1932:
1928:
1883:
1872:
1835:
1822:
1809:
1808:
1804:
1791:
1790:
1786:
1774:
1765:
1753:
1744:
1739:
1727:
1683:
1674:
1652:/BCL-X(L), and
1633:
1590:View/Edit Mouse
1585:View/Edit Human
1548:
1541:
1538:Location (UCSC)
1524:
1520:
1516:
1512:
1508:
1502:
1498:
1494:
1490:
1486:
1467:
1463:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1413:
1409:
1405:
1401:
1397:
1373:
1369:
1365:
1361:
1357:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1282:
1278:
1274:
1270:
1266:
1181:ENSG00000153094
1074:
980:spermatogenesis
885:ear development
808:
732:
708:protein binding
673:
663:
662:
635:
626:
621:
617:
613:
609:
605:
601:
597:
593:
589:
575:
564:
559:
555:
553:mucosa of colon
551:
547:
543:
539:
535:
531:
527:
513:
457:
444:
436:
426:
425:
424:
417:
397:
374:Gene location (
356:
343:
335:
325:
324:
323:
316:
294:
271:Gene location (
222:
209:
202:
75:
53:
17:
12:
11:
5:
3024:
3014:
3013:
3008:
2992:
2991:
2984:
2977:
2969:
2966:
2965:
2944:
2930:
2929:
2917:
2903:
2902:External links
2900:
2898:
2897:
2862:
2834:(1–3): 29–34.
2819:
2798:
2755:
2718:
2675:
2640:
2603:
2560:
2523:
2487:(19): 1201–4.
2472:
2443:
2408:
2373:
2345:(4): 1029–39.
2330:
2287:
2251:
2249:
2246:
2243:
2242:
2221:(17): 167499.
2201:
2160:
2119:
2070:
2035:
2014:(3): 393–403.
1989:
1940:
1926:
1870:
1849:(9): 1432–40.
1843:Mol Endocrinol
1820:
1802:
1784:
1763:
1741:
1740:
1738:
1735:
1734:
1733:
1726:
1723:
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1477:
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1284:
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1159:
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1131:
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1124:
1118:
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1112:
1107:
1103:
1102:
1092:
1091:
1088:
1087:
1076:
1075:
1073:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
945:tube formation
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
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809:
807:
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801:
796:
791:
786:
781:
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771:
766:
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746:
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632:
631:
628:
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625:
624:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
581:
580:
569:
566:
565:
563:
562:
561:jejunal mucosa
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
519:
518:
506:
505:
497:
486:
480:
479:
476:RNA expression
468:
467:
464:
463:
455:
451:
450:
442:
439:
434:
428:
427:
418:
411:
405:
401:
400:
395:
389:
388:
380:
379:
367:
366:
363:
362:
354:
350:
349:
341:
338:
333:
327:
326:
317:
310:
304:
300:
299:
292:
286:
285:
277:
276:
264:
263:
220:
216:
215:
207:
199:
198:
194:
193:
190:
189:
186:
185:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
3023:
3012:
3009:
3007:
3004:
3003:
3001:
2990:
2985:
2983:
2978:
2976:
2971:
2970:
2964:
2962:
2958:
2954:
2950:
2945:
2942:
2938:
2937:
2933:
2927:
2923:
2922:
2918:
2915:
2911:
2910:
2906:
2905:
2894:
2890:
2885:
2880:
2876:
2872:
2868:
2863:
2859:
2855:
2851:
2847:
2842:
2837:
2833:
2829:
2825:
2820:
2816:
2812:
2808:
2804:
2799:
2795:
2791:
2786:
2781:
2777:
2773:
2769:
2765:
2761:
2756:
2752:
2748:
2744:
2740:
2736:
2732:
2728:
2724:
2719:
2715:
2711:
2707:
2703:
2698:
2693:
2690:(1): 135–41.
2689:
2685:
2681:
2676:
2672:
2668:
2663:
2658:
2655:(3): 705–11.
2654:
2650:
2646:
2641:
2637:
2633:
2629:
2625:
2621:
2617:
2613:
2609:
2604:
2600:
2596:
2592:
2588:
2583:
2578:
2575:(3): 615–28.
2574:
2570:
2566:
2561:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2524:
2520:
2516:
2512:
2508:
2503:
2498:
2494:
2490:
2486:
2482:
2478:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2444:
2440:
2436:
2431:
2426:
2423:(4): 314–25.
2422:
2418:
2414:
2409:
2405:
2401:
2396:
2391:
2388:(3): 287–96.
2387:
2383:
2379:
2374:
2370:
2366:
2361:
2356:
2352:
2348:
2344:
2340:
2336:
2331:
2327:
2323:
2319:
2315:
2310:
2305:
2302:(4): 619–28.
2301:
2297:
2293:
2288:
2284:
2280:
2275:
2270:
2266:
2262:
2258:
2253:
2252:
2238:
2234:
2229:
2224:
2220:
2216:
2212:
2205:
2197:
2193:
2188:
2183:
2179:
2175:
2174:J. Biol. Chem
2171:
2164:
2156:
2152:
2147:
2142:
2139:(6): 575–85.
2138:
2134:
2130:
2123:
2115:
2111:
2106:
2101:
2097:
2093:
2089:
2085:
2081:
2074:
2066:
2062:
2058:
2054:
2050:
2046:
2045:Anal. Biochem
2039:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
1998:
1996:
1994:
1985:
1981:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1944:
1936:
1930:
1922:
1918:
1913:
1908:
1904:
1900:
1897:(2): 384–95.
1896:
1892:
1888:
1881:
1879:
1877:
1875:
1866:
1862:
1857:
1852:
1848:
1844:
1840:
1833:
1831:
1829:
1827:
1825:
1816:
1812:
1806:
1798:
1794:
1788:
1781:
1777:
1772:
1770:
1768:
1760:
1756:
1751:
1749:
1747:
1742:
1732:
1729:
1728:
1719:
1716:
1713:
1710:
1707:
1704:
1701:
1698:
1695:
1692:
1691:
1690:
1688:
1678:
1669:
1667:
1663:
1659:
1655:
1651:
1647:
1642:
1638:
1628:
1626:
1623:
1619:
1615:
1611:
1607:
1603:
1591:
1586:
1582:
1578:
1575:
1571:
1564:
1562:
1559:
1555:
1551:
1547:
1544:
1540:
1536:
1529:
1527:
1523:
1519:
1515:
1511:
1505:
1501:
1497:
1493:
1489:
1485:
1481:
1478:
1472:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1416:
1412:
1408:
1404:
1400:
1396:
1392:
1389:
1385:
1378:
1376:
1372:
1368:
1364:
1360:
1354:
1350:
1347:
1341:
1339:
1335:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1285:
1281:
1277:
1273:
1269:
1265:
1261:
1258:
1256:RefSeq (mRNA)
1254:
1247:
1246:
1241:
1237:
1234:
1228:
1227:
1222:
1218:
1215:
1213:
1209:
1202:
1201:
1196:
1192:
1189:
1183:
1182:
1177:
1173:
1170:
1168:
1164:
1157:
1156:
1151:
1147:
1144:
1138:
1137:
1132:
1128:
1125:
1123:
1119:
1116:
1113:
1111:
1108:
1104:
1101:
1097:
1093:
1086:
1082:
1077:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
817:
815:
812:
811:
805:
802:
800:
797:
795:
792:
790:
787:
785:
784:mitochondrion
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
741:
739:
736:
735:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
705:
703:
700:
699:
696:
695:Gene ontology
692:
688:
676:
671:
667:
660:
655:
652:
650:
646:
638:
633:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
585:
582:
578:
573:
570:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
523:
520:
516:
511:
508:
507:
504:
502:
498:
496:
495:
491:
490:
487:
485:
481:
477:
473:
469:
461:
456:
452:
448:
443:
433:
429:
422:
415:
409:
402:
394:
390:
386:
381:
377:
372:
368:
360:
355:
351:
347:
342:
332:
328:
321:
314:
308:
301:
297:
291:
287:
283:
278:
274:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
217:
212:
205:
200:
195:
184:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2961:expanding it
2953:chromosome 2
2946:
2931:
2920:
2908:
2874:
2870:
2831:
2827:
2806:
2802:
2767:
2763:
2726:
2722:
2687:
2683:
2652:
2648:
2614:(3–4): 353.
2611:
2607:
2572:
2568:
2534:(2): 163–8.
2531:
2528:Mamm. Genome
2527:
2484:
2480:
2451:
2447:
2420:
2416:
2385:
2381:
2342:
2338:
2299:
2295:
2264:
2260:
2218:
2214:
2204:
2177:
2173:
2163:
2136:
2132:
2122:
2087:
2083:
2073:
2051:(2): 170–8.
2048:
2044:
2038:
2011:
2007:
1957:
1953:
1943:
1929:
1894:
1890:
1846:
1842:
1814:
1805:
1796:
1787:
1684:
1681:Interactions
1675:
1634:
1621:
1613:
1609:
1605:
1601:
1600:
1526:NP_001392990
1522:NP_001392989
1518:NP_001392988
1514:NP_001392987
1510:NP_001392986
1507:
1488:NP_001277945
1484:NP_001271339
1429:NP_001191042
1425:NP_001191041
1421:NP_001191040
1418:
1411:NP_001191039
1407:NP_001191038
1403:NP_001191037
1399:NP_001191036
1395:NP_001191035
1363:NM_001291016
1359:NM_001284410
1356:
1298:NM_001204113
1294:NM_001204112
1290:NM_001204111
1287:
1280:NM_001204110
1276:NM_001204109
1272:NM_001204108
1268:NM_001204107
1264:NM_001204106
1243:
1224:
1198:
1179:
1153:
1134:
1114:
1109:
595:ciliary body
499:
492:
458:128,004,467
445:127,967,958
357:111,168,445
344:111,119,378
219:External IDs
74:
18:
2133:Cancer Cell
1694:BCL2-like 1
1612:nteracting
789:microtubule
437:2|2 F1
197:Identifiers
3000:Categories
2803:Cancer Res
2481:Curr. Biol
2084:Biochem. J
1954:Oncotarget
1782:, May 2017
1761:, May 2017
1737:References
503:(ortholog)
240:HomoloGene
2951:on human
2828:FEBS Lett
2684:FEBS Lett
2649:Mol. Cell
2382:Mol. Cell
2261:Genes Dev
2008:Mol. Cell
1666:thymocyte
1641:apoptotic
1500:NP_997564
1496:NP_997563
1492:NP_033884
1469:NP_996886
1465:NP_996885
1461:NP_619533
1457:NP_619532
1453:NP_619531
1449:NP_619530
1445:NP_619529
1441:NP_619528
1437:NP_619527
1433:NP_006529
1375:NM_207681
1371:NM_207680
1367:NM_009754
1338:NM_207003
1334:NM_207002
1330:NM_138627
1326:NM_138626
1322:NM_138625
1318:NM_138624
1314:NM_138623
1310:NM_138622
1306:NM_138621
1302:NM_006538
1100:Orthologs
975:meiosis I
744:cytoplasm
248:GeneCards
2893:12118373
2871:Oncogene
2858:20419085
2850:12095614
2815:12019181
2794:11997495
2743:11859372
2714:82875886
2706:11734221
2671:11583631
2636:32790948
2628:11435715
2599:16223140
2591:11301022
2548:11210187
2519:17945478
2511:11050388
2468:10576740
2439:10381623
2404:10198631
2237:35189130
2196:10837489
2155:15193260
2114:14561217
2065:14596824
2030:15694340
1984:26405162
1778:–
1757:–
1725:See also
1687:interact
1631:Function
1574:Wikidata
1079:Sources:
754:membrane
549:monocyte
2921:BCL2L11
2909:BCL2L11
2751:1404636
2556:7225766
2489:Bibcode
2448:Science
2369:9463381
2360:1170452
2318:8929531
2283:8918887
2105:1223895
1975:4695108
1921:9430630
1912:1170389
1865:9731710
1780:Ensembl
1759:Ensembl
1622:BCL2L11
1618:protein
1212:UniProt
1167:Ensembl
1106:Species
1085:QuickGO
749:cytosol
607:utricle
478:pattern
252:BCL2L11
236:1197519
211:BCL2L11
204:Aliases
24:BCL2L11
2891:
2856:
2848:
2813:
2792:
2785:133811
2782:
2749:
2741:
2723:Nature
2712:
2704:
2669:
2634:
2626:
2597:
2589:
2569:Neuron
2554:
2546:
2517:
2509:
2466:
2437:
2402:
2367:
2357:
2339:EMBO J
2326:860908
2324:
2316:
2281:
2235:
2194:
2153:
2112:
2102:
2063:
2028:
1982:
1972:
1919:
1909:
1891:EMBO J
1863:
1714:, and
1712:DYNLL1
1700:BCL2L2
1689:with:
1662:FoxO3a
1650:BCL2L1
1560:search
1558:PubMed
1245:O54918
1226:O43521
1122:Entrez
649:BioGPS
228:603827
2955:is a
2854:S2CID
2747:S2CID
2710:S2CID
2632:S2CID
2595:S2CID
2552:S2CID
2515:S2CID
2322:S2CID
1731:Bcl-2
1706:Bcl-2
1637:BCL-2
1608:cl-2
1155:12125
1136:10018
1115:Mouse
1110:Human
1081:Amigo
619:blood
525:sperm
501:Mouse
494:Human
441:Start
376:Mouse
340:Start
273:Human
2957:stub
2949:gene
2889:PMID
2846:PMID
2811:PMID
2790:PMID
2739:PMID
2702:PMID
2667:PMID
2624:PMID
2587:PMID
2544:PMID
2507:PMID
2464:PMID
2435:PMID
2400:PMID
2365:PMID
2314:PMID
2296:Cell
2279:PMID
2233:PMID
2192:PMID
2151:PMID
2110:PMID
2061:PMID
2026:PMID
1980:PMID
1917:PMID
1861:PMID
1718:MCL1
1654:MCL1
1646:BCL2
1625:gene
484:Bgee
432:Band
393:Chr.
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