29:
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to develop and manufacture this vaccine regimen intended for emergency use to help contain the outbreak in West Africa. In
January 2015, the company had produced the first 400,000 doses of the vaccine and the first clinical trial of the vaccine regimen was initiated in the UK, with additional trials
654:
Acquisition completed on 31 December 2019. Bavarian Nordic assumes full sales and marketing responsibility from start 2020; manufacturing transfer takes place 2020–25 – during this period
Bavarian Nordic will purchase remaining inventory of vaccines from GSK at different levels in the supply chain.
635:
Acquisition completed on 31 December 2019. Bavarian Nordic assumes full sales and marketing responsibility from start 2020; manufacturing transfer takes place 2020–25 – during this period
Bavarian Nordic will purchase remaining inventory of vaccines from GSK at different levels in the supply chain.
456:
diseases. In
October 2014, following a successful pre-clinical demonstration of the combination vaccine regimen of its multivalent MVA-BN Filovirus vaccine and Crucell/Janssen's AdVac technology based on adenoviral vectors, Bavarian Nordic joined efforts with
1033:
732:, a group of companies, academic institutions, and other organizations dedicated to building an effective medical countermeasure enterprise through sound public policy and strong public-private partnerships.
1144:
Greenberg RN, Hay CM, Stapleton JT, Marbury TC, Wagner E, Kreitmeir E, Röesch S, von
Krempelhuber A, Young P, Nichols R, Meyer TP, Schmidt D, Weigl J, Virgin G, Arndtz-Wiedemann N, Chaplin P (2016).
1146:"A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BN) in 56-80-Year-Old Subjects"
1601:
729:
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1932:
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782:
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908:
390:-based vaccines, which may replicate in humans, thus potentially causing severe and life-threatening side effects. Developed as the non-replicating
331:
1912:
83:
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1122:
1937:
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1203:
Exclusive: Closure of World's Only
Manufacturing Plant for Monkeypox Vaccine Raises Questions About World's Ability to Meet Rising Demand
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878:
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318:
company focused on the development, manufacturing and commercialization of vaccines. The company is headquartered in
1330:
1509:"Bavarian Nordic Reports Positive Phase 3 Topline Results for Chikungunya Virus Vaccine in Adults and Adolescents"
1574:
1202:
1553:"Bavarian Nordic Announces Topline Results from Phase 1 Clinical Trial of Equine Encephalitis Virus Vaccine"
1266:
478:
In
October 2019, it was announced that Bavarian Nordic would acquire travel vaccines Rabipur(/Rabavert) for
1073:
419:
915:
362:
157:
1530:
717:
Ph1 topline results announced 8 June 2020. A Phase 2 clinical study is planned for initiation in 2024.
429:, leading to concerns over vaccine nationalism and hoarding by countries with pre-existing contracts.
60:
1430:"Bavarian Nordic scoops up Emergent's travel vaccines, manufacturing site in deal worth up to $ 380M"
1357:"Johnson & Johnson Announces European Commission Approval for Janssen's Preventive Ebola Vaccine"
1041:
946:
1552:
1508:
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383:
470:
planned in the US and Africa. It was approved for medical use in the
European Union in July 2020.
1111:
645:
483:
462:
453:
426:
161:
831:
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386:
virus. MVA-BN is characterized by the inability to replicate in human cells, contrary to other
1483:
1596:
1241:"Bavarian Nordic Enters Licensing and Supply Agreement with Janssen on MVA-BN® Ebola Vaccine"
507:
490:(GSK). In February 2023, it was announced that Bavarian Nordic would acquire travel vaccines
450:
682:
678:
660:
567:
540:
207:
1454:
1405:"GSK agrees to divest rabies and tick-borne encephalitis vaccines to Bavarian Nordic | GSK"
1157:
585:
466:
1244:
8:
446:
1876:
1218:
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853:
382:
MVA-BN is a proprietary technology developed by
Bavarian Nordic. It is derived from the
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1145:
1067:
981:
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941:
701:
Ph3 topline results announced 6 August 2023. Regulatory submissions planned for 2024.
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942:"IMVAMUNE: modified vaccinia Ankara strain as an attenuated smallpox vaccine"
669:
495:
315:
100:
56:
47:
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977:
681:(Ad26.ZEBOV) followed 8 weeks later by a dose of Bavarian Nordic's booster
366:
265:
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223:
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685:(MVA-BN Filo) collectively constitutes Janssen's Ebola vaccine regimen.
1821:
28:
345:, Switzerland. The company has research and development facilities in
1841:
1786:
1331:"J&J, Bavarian Nordic start clinical tests in Ebola vaccine race"
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Bavarian Nordic's marketed products and pipeline, as of July 2020.
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This article incorporates text from this source, which is in the
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1267:"BRIEF-Bavarian Nordic to expand collaboration with Janssen"
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342:
1010:. 13 June 2014. 144762 (Submission Number). Archived from
369:
and virus-like particles in its research and development.
354:
1918:
Companies traded over-the-counter in the United States
425:
The vaccine is being deployed worldwide to combat the
1117:
National
Institute of Allergy and Infectious Diseases
418:. The vaccine was supplied for emergency use to the
1380:"GSK to divest Rabipur, Encepur to Bavarian Nordic"
1307:. Associated Press. 22 October 2014. Archived from
1301:"Johnson & Johnson plans Ebola vaccine testing"
1243:. Bavarian Nordic. 22 October 2014. Archived from
677:Licensed to Janssen. One dose of Janssen's primer
437:The company has worked for several years with the
513:
353:and San Diego, California, as well as offices in
1889:
939:
781:: CS1 maint: bot: original URL status unknown (
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763:. Archived from the original on 13 March 2022
1933:Pharmaceutical companies established in 1994
1000:"Products for Human Use. Submission #144762"
992:
502:, in addition to a late-stage candidate for
940:Kennedy JS, Greenberg RN (9 January 2014).
1928:Life science companies based in Copenhagen
1728:
1714:
817:
1179:
1169:
967:
1903:Companies based in Gentofte Municipality
1215:"Infectious Diseases: Filovirus Vaccine"
1112:"Smallpox Vaccine Supply & Strength"
735:The company is a funding partner of the
626:(Pre-/post-exposure protection against)
433:Ebola vaccine development and production
422:as well as other government stockpiles.
1890:
1913:Companies listed on Nasdaq Copenhagen
1709:
1477:"Annual Report 2019, Pipeline (p.30)"
1377:
1923:Danish companies established in 1994
1337:from the original on 13 January 2015
1281:from the original on 30 October 2014
1125:from the original on 17 October 2019
1082:from the original on 17 October 2019
1938:Pharmaceutical companies of Denmark
1629:Bipartisan Commission on Biodefense
1457:. Bavarian Nordic. 20 February 2020
737:Bipartisan Commission on Biodefense
728:Bavarian Nordic is a member of the
618:Phase 3 clinical trials completed.
326:, with manufacturing facilities in
13:
1908:Companies in the OMX Copenhagen 25
1898:Biotechnology companies of Denmark
1026:
14:
1949:
1690:
1602:Medical Countermeasures Coalition
1482:. Bavarian Nordic. Archived from
1217:. Bavarian Nordic. Archived from
1078:. 24 September 2019. STN 125678.
914:. Bavarian Nordic. Archived from
830:. Bavarian Nordic. Archived from
730:Medical Countermeasures Coalition
710:Western equine encephalitis virus
420:U.S. Strategic National Stockpile
1737:
1674:from the original on 7 July 2022
1636:from the original on 29 May 2022
1511:. Bavarian Nordic. 6 August 2023
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1378:Smith, Anna (21 October 2019).
1371:
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797:"OMX Copenhagen 25 (OMXC25CAP)"
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398:vaccine, MVA-BN is approved in
372:
303:Footnotes / references
1555:. Bavarian Nordic. 8 June 2020
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871:
846:
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514:Marketed products and pipeline
1:
1044:. 27 May 2016. Archived from
746:
1171:10.1371/journal.pone.0157335
1074:Food and Drug Administration
1004:Register of Innovative Drugs
739:, and a former donor to the
7:
1333:. Reuters. 6 January 2015.
414:, and the United States as
363:Morrisville, North Carolina
112:; 30 years ago
10:
1954:
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1042:European Medicines Agency
947:Expert Review of Vaccines
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35:
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1664:Bipartisan Policy Center
741:Bipartisan Policy Center
441:on the development of a
384:Modified vaccinia Ankara
960:10.1586/14760584.8.1.13
646:tick-borne encephalitis
577:Approved Canada 2013-11
484:tick-borne encephalitis
463:Janssen Pharmaceuticals
1597:"Member Organizations"
1359:. Reuters. 1 July 2020
879:"Executive Management"
674:Approved EU 2020-07-01
599:Approved US 2019-09-24
552:and disease caused by
314:is a fully integrated
16:Pharmaceutical company
1575:"Equine Encephalitis"
1121:. 26 September 2019.
607:MVA-BN (freeze-dried)
508:Emergent BioSolutions
467:Johnson & Johnson
1656:"2017 Annual Report"
909:"Annual Report 2023"
854:"Board of Directors"
459:Crucell Holland B.V.
264:10.340 billion
243:14.373 billion
1867:Vestas Wind Systems
1624:"Sponsors / Donors"
1277:. 23 October 2014.
1162:2016PLoSO..1157335G
828:"Hellerup, Denmark"
644:European (Western)
559:Approved EU 2013-07
365:. The company uses
312:Bavarian Nordic A/S
274:Number of employees
222:7.062 billion
23:
22:Bavarian Nordic A/S
1311:on 31 October 2014
1247:on 3 November 2014
1221:on 30 October 2014
427:2022 mpox outbreak
21:
1885:
1884:
1767:A.P. Møller-Mærsk
1744:OMX Copenhagen 25
1577:. Bavarian Nordic
1533:. Bavarian Nordic
813:on 13 March 2022.
721:
720:
498:and Vaxchora for
454:hemorrhagic fever
309:
308:
57:Nasdaq Copenhagen
1945:
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834:on 13 March 2022
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623:Rabipur/RabAvert
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1038:Human Medicines
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1014:on 17 June 2014
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602:Liquid-frozen.
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