407:
384:
1066:
701:
29:
1088:
610:
severity marker. In addition, a prospective observational study of dyslipidemic patients with diabetes or hyperglycemia showed that bezafibrate significantly reduces haemoglobin A1c (HbA1c) concentration as a function of baseline HbA1c levels, regardless of concurrent use of antidiabetic drugs.
676:
The combination of a cholesterol-lowering drug, bezafibrate, and a contraceptive steroid, medroxyprogesterone acetate, could be an effective, non-toxic treatment for a range of cancers, researchers at the
University of Birmingham have found.
2301:
2162:
1943:
1061:, Witte EC, Stach K, Stork H, Thiel M, Schmidt F, "Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben ", published 1973-04-05, issued 23 April 1978, assigned to
2278:
602:, the features of which are attenuated by bezafibrate. Studies show that in patients with impaired glucose tolerance, bezafibrate may delay progress to diabetes, and in those with
2283:
2715:
1493:
85:
476:
2481:
2262:
2141:
1922:
1120:
1083:, Witte EC, Stach K, Stork H, Thiel M, Schmidt F, "Phenoxy-alkyl-carboxylic acid compounds", issued 25 December 1973, assigned to
860:"Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease"
2597:
2316:
2519:
2489:
2466:
2461:
2446:
2361:
2336:
2456:
2401:
2366:
41:
2494:
2187:
598:, effectively reducing LDL and triglycerides and improving HDL levels. The main effect on cardiovascular morbidity is in patients with the
490:
2602:
2426:
2421:
2416:
2217:
2207:
2046:
2041:
1978:
2252:
2247:
2116:
1906:
686:
2612:
2592:
2572:
2567:
2391:
2126:
2023:
1897:
1787:
697:
Further evidence that substantial bulk tolerance is available in the para position is given by the lipid lowering agent bezafibrate.
518:
InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
2587:
2577:
2509:
2441:
2242:
1372:
720:
with ethyl 2-bromo-2-methylpropionate to complete the synthesis. The ester group is hydrolyzed in the alkaline reaction medium.
1841:
1113:
2288:
535:
2720:
778:"Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease"
760:
640:
510:
1875:
942:"Effects of bezafibrate on lipid and glucose metabolism in dyslipidemic patients with diabetes: the J-BENEFIT study"
1858:
1151:
1106:
161:
115:
2296:
2157:
1938:
232:
1890:
2693:
2557:
1376:
1142:
607:
402:
283:
2547:
901:"Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate"
363:
352:
819:"Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome"
717:
666:
1080:
1058:
2232:
2106:
1802:
1883:
1701:
1667:
1582:
1324:
580:
379:
1846:
1726:
1721:
1696:
1663:
1625:
1409:
1328:
1264:
1191:
1040:
991:
Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova N, et al. (December 2012).
858:
Tenenbaum A, Motro M, Fisman EZ, Schwammenthal E, Adler Y, Goldenberg I, et al. (May 2004).
595:
568:
73:
2471:
2081:
2076:
1988:
1711:
1706:
750:
332:
2066:
1716:
1183:
644:
223:
1953:
1757:
1483:
1342:
560:
292:
272:
187:
8:
2725:
1129:
993:"Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice"
729:
178:
899:
Tenenbaum A, Fisman EZ, Boyko V, Benderly M, Tanne D, Haim M, et al. (April 2006).
406:
383:
1914:
1741:
1187:
1017:
992:
968:
941:
876:
859:
603:
599:
51:
2061:
1905:
1736:
1405:
1362:
1260:
1022:
973:
922:
881:
840:
799:
756:
143:
130:
65:
2311:
2167:
1958:
1012:
1004:
963:
953:
912:
871:
830:
789:
419:
98:
776:
Behar S, et al. (Bezafibrate
Infarction Prevention (BIP) study) (July 2000).
212:
1621:
1437:
835:
818:
658:
564:
2033:
1852:
1578:
1418:
917:
900:
628:
1098:
1079:
1057:
2709:
2671:
2661:
2524:
2504:
2499:
2451:
2431:
2227:
2096:
2051:
1225:
1215:
689:; some studies suggest it may have some activity on PPARγ and PPARδ as well.
395:
958:
794:
777:
20:
2636:
2631:
2539:
2534:
2514:
2476:
2436:
2411:
2406:
2356:
2212:
2111:
2101:
2091:
2086:
2056:
2028:
1827:
1503:
1498:
1465:
1456:
1428:
1357:
1308:
1298:
1278:
1273:
1133:
1026:
977:
926:
885:
844:
803:
572:
93:
2666:
2656:
2646:
2529:
2381:
2371:
2346:
2341:
2331:
2306:
2182:
2071:
2018:
2008:
1998:
1968:
1948:
1807:
1782:
1762:
1731:
1639:
1611:
1606:
1601:
1596:
1591:
1543:
1538:
1528:
1523:
1395:
1385:
1313:
1303:
1283:
1233:
1200:
1084:
1062:
1008:
655:
648:
59:
2263:
2142:
1923:
700:
252:
2676:
2651:
2641:
2222:
1992:
1973:
1822:
1797:
1777:
1772:
1767:
1676:
1649:
1644:
1634:
1548:
1518:
1513:
1508:
1442:
1390:
1352:
1293:
1288:
1210:
1205:
1168:
817:
Tenenbaum A, Motro M, Fisman EZ, Tanne D, Boyko V, Behar S (May 2005).
452:
263:
2396:
2386:
2321:
2202:
2192:
2013:
1533:
1220:
1173:
1163:
662:
198:
45:
2376:
2351:
2177:
2003:
1983:
1817:
1812:
1792:
1564:
1337:
1229:
713:
670:
624:
312:
243:
1907:
1041:"Contraceptive, Cholesterol - lowering drugs used to treat cancer"
475:
2562:
2197:
1659:
1475:
857:
553:
2131:
1347:
1256:
1155:
343:
990:
586:
It was patented in 1971 and approved for medical use in 1978.
28:
1247:
620:
576:
466:
323:
898:
368:
556:
303:
939:
816:
2268:
Tooltip
Peroxisome proliferator-activated receptor gamma
2147:
Tooltip
Peroxisome proliferator-activated receptor delta
1928:
Tooltip
Peroxisome proliferator-activated receptor alpha
940:
Teramoto T, Shirai K, Daida H, Yamada N (March 2012).
685:
Like the other fibrates, bezafibrate is an agonist of
231:
1912:Tooltip Peroxisome proliferator-activated receptor
2548:
2707:
211:
1128:
748:
186:
1891:
1114:
169:2-(4-{2-ethyl}phenoxy)-2-methylpropanoic acid
2716:2-Methyl-2-phenoxypropanoic acid derivatives
498:O=C(c1ccc(Cl)cc1)NCCc2ccc(OC(C(=O)O)(C)C)cc2
1898:
1884:
1121:
1107:
405:
382:
271:
27:
1788:Magnesium pyridoxal 5-phosphate glutamate
1016:
967:
957:
916:
875:
834:
793:
291:
699:
378:
251:
64:
2708:
755:. John Wiley & Sons. p. 474.
742:
396:
124:
1879:
1102:
775:
654:Bezafibrate has been shown to reduce
351:
331:
137:
50:
728:Bezafibrate was first introduced by
552:and various other brand names) is a
97:
651:drug combination called Hepaconda.
311:
202:
13:
877:10.1161/01.CIR.0000126824.12785.B6
14:
2737:
2553:Tooltip Selective PPARγ modulator
1152:Cholesterol absorption inhibitors
680:
594:Bezafibrate improves markers of
439:
436:
430:
1073:
749:Fischer J, Ganellin CR (2006).
639:The Australian biotech company
614:
589:
523:Key:IIBYAHWJQTYFKB-UHFFFAOYSA-N
1051:
1033:
984:
933:
892:
851:
810:
769:
442:
424:
1:
2694:Receptor/signaling modulators
905:Archives of Internal Medicine
823:Archives of Internal Medicine
752:Analogue-based Drug Discovery
735:
634:
836:10.1001/archinte.165.10.1154
692:
7:
2437:Muraglitazar (muroglitazar)
10:
2742:
2289:15-Deoxy-Δ-prostaglandin J
946:Cardiovascular Diabetology
918:10.1001/archinte.166.7.737
723:
718:Williamson ether synthesis
643:combines bezafibrate with
623:(abnormal liver enzymes);
606:it slowed progress in the
414:Chemical and physical data
2685:
2621:
2261:
2233:Tetradecylthioacetic acid
2140:
2107:Tetradecylthioacetic acid
1921:
1836:
1803:Omega−3-acid ethyl esters
1750:
1689:
1658:
1620:
1577:
1557:
1474:
1464:
1455:
1427:
1404:
1371:
1322:
1255:
1246:
1182:
1150:
1141:
531:
506:
486:
464:
451:
418:
413:
394:
362:
342:
322:
302:
282:
262:
242:
222:
197:
177:
157:
152:
114:
109:
84:
72:
58:
40:
35:
26:
2721:4-Chlorophenyl compounds
1702:Bempedoic acid/ezetimibe
1323:Niacin and derivatives (
1085:Boehringer Mannheim GmbH
1063:Boehringer Mannheim GmbH
997:Human Molecular Genetics
52:International Drug Names
1727:Fenofibrate/simvastatin
1722:Fenofibrate/pravastatin
1697:Amlodipine/atorvastatin
959:10.1186/1475-2840-11-29
795:10.1161/01.cir.102.1.21
596:combined hyperlipidemia
2472:Perfluorononanoic acid
2082:Perfluorooctanoic acid
2077:Perfluorononanoic acid
1712:Ezetimibe/rosuvastatin
1707:Ezetimibe/atorvastatin
1184:Bile acid sequestrants
705:
704:Bezafibrate synthesis:
627:and on rare occasions
2067:Palmitoylethanolamide
1717:Ezetimibe/simvastatin
1130:Lipid-lowering agents
703:
645:chenodeoxycholic acid
619:The main toxicity is
2284:5-Oxo-15-hydroxy-ETE
1954:Aluminium clofibrate
1758:Alipogene tiparvovec
1484:Aluminium clofibrate
1343:Aluminium nicotinate
712:-chlorobenzamide of
659:hyperphosphorylation
631:have been reported.
567:. It helps to lower
561:lipid-lowering agent
1494:Choline fenofibrate
730:Boehringer Mannheim
661:and other signs of
133:(Prescription only)
23:
1863:Never to phase III
1742:Niacin/simvastatin
1732:Niacin/laropiprant
1009:10.1093/hmg/dds355
706:
604:insulin resistance
600:metabolic syndrome
19:
2703:
2702:
2062:Oleylethanolamide
1873:
1872:
1737:Niacin/lovastatin
1685:
1684:
1573:
1572:
1451:
1450:
1406:ATP citrate lyase
1363:Nicotinyl alcohol
1261:HMG-CoA reductase
1242:
1241:
1003:(23): 5091–5105.
870:(18): 2197–2202.
829:(10): 1154–1160.
669:having human tau
543:
542:
477:Interactive image
364:CompTox Dashboard
141:
128:
16:Chemical compound
2733:
2554:
2550:
2312:Arachidonic acid
2269:
2265:
2168:Arachidonic acid
2148:
2144:
1959:Arachidonic acid
1929:
1925:
1913:
1909:
1900:
1893:
1886:
1877:
1876:
1622:PCSK9 inhibitors
1472:
1471:
1462:
1461:
1253:
1252:
1148:
1147:
1123:
1116:
1109:
1100:
1099:
1093:
1092:
1091:
1087:
1077:
1071:
1070:
1069:
1065:
1055:
1049:
1048:
1037:
1031:
1030:
1020:
988:
982:
981:
971:
961:
937:
931:
930:
920:
896:
890:
889:
879:
855:
849:
848:
838:
814:
808:
807:
797:
773:
767:
766:
746:
539:
538:
479:
459:
444:
441:
438:
432:
426:
409:
398:
387:
386:
372:
370:
355:
335:
315:
295:
275:
255:
235:
215:
205:
204:
190:
139:
136:
126:
123:
101:
68:
54:
31:
24:
22:
18:
2741:
2740:
2736:
2735:
2734:
2732:
2731:
2730:
2706:
2705:
2704:
2699:
2681:
2617:
2552:
2485:
2482:Prostaglandin J
2292:
2267:
2257:
2146:
2136:
2037:
1927:
1917:
1911:
1904:
1874:
1869:
1868:
1853:Clinical trials
1832:
1746:
1681:
1654:
1616:
1579:CETP inhibitors
1569:
1553:
1447:
1438:Dextrothyroxine
1423:
1400:
1367:
1318:
1238:
1178:
1137:
1127:
1097:
1096:
1089:
1078:
1074:
1067:
1056:
1052:
1039:
1038:
1034:
989:
985:
938:
934:
897:
893:
856:
852:
815:
811:
774:
770:
763:
747:
743:
738:
726:
695:
683:
667:transgenic mice
637:
617:
592:
579:, and increase
569:LDL cholesterol
565:hyperlipidaemia
534:
532:
527:
524:
519:
514:
513:
502:
499:
494:
493:
482:
457:
447:
435:
429:
390:
366:
358:
338:
318:
298:
278:
258:
238:
218:
201:
193:
173:
170:
165:
164:
148:
105:
75:
17:
12:
11:
5:
2739:
2729:
2728:
2723:
2718:
2701:
2700:
2698:
2697:
2690:
2686:
2683:
2682:
2680:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2625:
2623:
2619:
2618:
2616:
2615:
2606:
2605:
2600:
2595:
2590:
2581:
2580:
2575:
2570:
2565:
2560:
2543:
2542:
2537:
2532:
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
2483:
2479:
2474:
2469:
2464:
2459:
2454:
2449:
2444:
2439:
2434:
2429:
2424:
2419:
2414:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2349:
2344:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2290:
2286:
2281:
2272:
2270:
2259:
2258:
2256:
2255:
2250:
2245:
2236:
2235:
2230:
2225:
2220:
2215:
2210:
2205:
2200:
2195:
2190:
2185:
2180:
2175:
2170:
2165:
2160:
2151:
2149:
2138:
2137:
2135:
2134:
2129:
2120:
2119:
2114:
2109:
2104:
2099:
2094:
2089:
2084:
2079:
2074:
2069:
2064:
2059:
2054:
2049:
2044:
2039:
2035:
2031:
2026:
2021:
2016:
2011:
2006:
2001:
1996:
1995:) (in rodents)
1986:
1981:
1976:
1971:
1966:
1961:
1956:
1951:
1946:
1941:
1932:
1930:
1919:
1918:
1903:
1902:
1895:
1888:
1880:
1871:
1870:
1867:
1866:
1865:
1864:
1861:
1850:
1844:
1838:
1837:
1834:
1833:
1831:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1765:
1760:
1754:
1752:
1748:
1747:
1745:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1709:
1704:
1699:
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1691:
1687:
1686:
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1682:
1680:
1679:
1673:
1671:
1656:
1655:
1653:
1652:
1647:
1642:
1637:
1631:
1629:
1618:
1617:
1615:
1614:
1609:
1604:
1599:
1594:
1588:
1586:
1575:
1574:
1571:
1570:
1568:
1567:
1561:
1559:
1555:
1554:
1552:
1551:
1546:
1541:
1536:
1531:
1526:
1521:
1516:
1511:
1506:
1501:
1496:
1491:
1486:
1480:
1478:
1469:
1459:
1453:
1452:
1449:
1448:
1446:
1445:
1440:
1434:
1432:
1425:
1424:
1422:
1421:
1419:Bempedoic acid
1415:
1413:
1402:
1401:
1399:
1398:
1393:
1388:
1382:
1380:
1369:
1368:
1366:
1365:
1360:
1355:
1350:
1345:
1340:
1334:
1332:
1320:
1319:
1317:
1316:
1311:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1270:
1268:
1250:
1244:
1243:
1240:
1239:
1237:
1236:
1223:
1218:
1213:
1208:
1203:
1197:
1195:
1180:
1179:
1177:
1176:
1171:
1166:
1160:
1158:
1145:
1139:
1138:
1126:
1125:
1118:
1111:
1103:
1095:
1094:
1072:
1050:
1047:. 14 May 2015.
1032:
983:
932:
911:(7): 737–741.
891:
850:
809:
768:
761:
740:
739:
737:
734:
725:
722:
694:
691:
682:
681:Mode of action
679:
636:
633:
629:rhabdomyolysis
616:
613:
591:
588:
541:
540:
529:
528:
526:
525:
522:
520:
517:
509:
508:
507:
504:
503:
501:
500:
497:
489:
488:
487:
484:
483:
481:
480:
472:
470:
462:
461:
455:
449:
448:
445:
433:
427:
422:
416:
415:
411:
410:
400:
392:
391:
389:
388:
375:
373:
360:
359:
357:
356:
348:
346:
340:
339:
337:
336:
328:
326:
320:
319:
317:
316:
308:
306:
300:
299:
297:
296:
288:
286:
280:
279:
277:
276:
268:
266:
260:
259:
257:
256:
248:
246:
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239:
237:
236:
228:
226:
220:
219:
217:
216:
208:
206:
195:
194:
192:
191:
183:
181:
175:
174:
172:
171:
168:
160:
159:
158:
155:
154:
150:
149:
147:
146:
134:
120:
118:
112:
111:
107:
106:
104:
103:
90:
88:
82:
81:
78:
76:administration
70:
69:
62:
56:
55:
48:
38:
37:
33:
32:
15:
9:
6:
4:
3:
2:
2738:
2727:
2724:
2722:
2719:
2717:
2714:
2713:
2711:
2696:
2695:
2691:
2688:
2687:
2684:
2678:
2675:
2673:
2672:Rivoglitazone
2670:
2668:
2665:
2663:
2662:Netoglitazone
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2627:
2626:
2624:
2622:Non-selective
2620:
2614:
2611:
2608:
2607:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2583:
2582:
2579:
2576:
2574:
2571:
2569:
2566:
2564:
2561:
2559:
2556:
2551:
2545:
2544:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2525:Sodelglitazar
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2505:Rosiglitazone
2503:
2501:
2500:Rivoglitazone
2498:
2496:
2493:
2491:
2488:
2486:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2452:Netoglitazone
2450:
2448:
2445:
2443:
2440:
2438:
2435:
2433:
2432:Lobeglitazone
2430:
2428:
2425:
2423:
2420:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2317:Balaglitazone
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2287:
2285:
2282:
2280:
2277:
2274:
2273:
2271:
2266:
2260:
2254:
2251:
2249:
2246:
2244:
2241:
2238:
2237:
2234:
2231:
2229:
2228:Sodelglitazar
2226:
2224:
2221:
2219:
2216:
2214:
2211:
2209:
2206:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2184:
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2164:
2161:
2159:
2156:
2153:
2152:
2150:
2145:
2139:
2133:
2130:
2128:
2125:
2122:
2121:
2118:
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2097:Sodelglitazar
2095:
2093:
2090:
2088:
2085:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2052:Lobeglitazone
2050:
2048:
2045:
2043:
2040:
2038:
2034:Leukotriene B
2032:
2030:
2027:
2025:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1994:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1934:
1933:
1931:
1926:
1920:
1916:
1910:
1901:
1896:
1894:
1889:
1887:
1882:
1881:
1878:
1862:
1860:
1857:
1856:
1854:
1851:
1848:
1845:
1843:
1840:
1839:
1835:
1829:
1826:
1824:
1821:
1819:
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1799:
1796:
1794:
1791:
1789:
1786:
1784:
1781:
1779:
1776:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1755:
1753:
1749:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1715:
1713:
1710:
1708:
1705:
1703:
1700:
1698:
1695:
1694:
1692:
1688:
1678:
1675:
1674:
1672:
1669:
1665:
1661:
1657:
1651:
1648:
1646:
1643:
1641:
1638:
1636:
1633:
1632:
1630:
1627:
1623:
1619:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1589:
1587:
1584:
1580:
1576:
1566:
1563:
1562:
1560:
1556:
1550:
1547:
1545:
1542:
1540:
1537:
1535:
1532:
1530:
1527:
1525:
1522:
1520:
1517:
1515:
1512:
1510:
1507:
1505:
1502:
1500:
1497:
1495:
1492:
1490:
1487:
1485:
1482:
1481:
1479:
1477:
1473:
1470:
1467:
1466:PPAR agonists
1463:
1460:
1458:
1457:Blood vessels
1454:
1444:
1441:
1439:
1436:
1435:
1433:
1430:
1429:Thyromimetics
1426:
1420:
1417:
1416:
1414:
1411:
1407:
1403:
1397:
1394:
1392:
1389:
1387:
1384:
1383:
1381:
1378:
1374:
1370:
1364:
1361:
1359:
1356:
1354:
1351:
1349:
1346:
1344:
1341:
1339:
1336:
1335:
1333:
1330:
1326:
1321:
1315:
1312:
1310:
1307:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1280:
1277:
1275:
1272:
1271:
1269:
1266:
1262:
1258:
1254:
1251:
1249:
1245:
1235:
1231:
1227:
1226:Soluble fiber
1224:
1222:
1219:
1217:
1216:Colestyramine
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1198:
1196:
1193:
1189:
1185:
1181:
1175:
1172:
1170:
1167:
1165:
1162:
1161:
1159:
1157:
1153:
1149:
1146:
1144:
1140:
1135:
1131:
1124:
1119:
1117:
1112:
1110:
1105:
1104:
1101:
1086:
1082:
1076:
1064:
1060:
1054:
1046:
1045:Science daily
1042:
1036:
1028:
1024:
1019:
1014:
1010:
1006:
1002:
998:
994:
987:
979:
975:
970:
965:
960:
955:
951:
947:
943:
936:
928:
924:
919:
914:
910:
906:
902:
895:
887:
883:
878:
873:
869:
865:
861:
854:
846:
842:
837:
832:
828:
824:
820:
813:
805:
801:
796:
791:
787:
783:
779:
772:
764:
762:9783527607495
758:
754:
753:
745:
741:
733:
731:
721:
719:
715:
711:
702:
698:
690:
688:
678:
674:
672:
668:
664:
660:
657:
652:
650:
646:
642:
632:
630:
626:
622:
612:
609:
605:
601:
597:
587:
584:
582:
578:
574:
570:
566:
562:
558:
555:
551:
548:(marketed as
547:
537:
530:
521:
516:
515:
512:
505:
496:
495:
492:
485:
478:
474:
473:
471:
468:
463:
456:
454:
450:
423:
421:
417:
412:
408:
404:
401:
399:
397:ECHA InfoCard
393:
385:
381:
380:DTXSID3029869
377:
376:
374:
365:
361:
354:
350:
349:
347:
345:
341:
334:
330:
329:
327:
325:
321:
314:
310:
309:
307:
305:
301:
294:
290:
289:
287:
285:
281:
274:
270:
269:
267:
265:
261:
254:
250:
249:
247:
245:
241:
234:
230:
229:
227:
225:
221:
214:
210:
209:
207:
200:
196:
189:
185:
184:
182:
180:
176:
167:
166:
163:
156:
151:
145:
135:
132:
122:
121:
119:
117:
113:
108:
100:
95:
92:
91:
89:
87:
83:
79:
77:
71:
67:
63:
61:
57:
53:
49:
47:
43:
39:
36:Clinical data
34:
30:
25:
2692:
2637:Clinofibrate
2632:Ciprofibrate
2628:
2609:
2585:Antagonists:
2584:
2546:
2540:Troglitazone
2535:Tesaglitazar
2520:Sipoglitazar
2515:Saroglitazar
2490:Ragaglitazar
2477:Pioglitazone
2467:Pemaglitazar
2462:Peliglitazar
2447:Naveglitazar
2412:Lanifibranor
2407:Indeglitazar
2362:Edaglitazone
2357:Darglitazone
2337:Cevoglitazar
2326:
2275:
2240:Antagonists:
2239:
2213:Lanifibranor
2172:
2154:
2124:Antagonists:
2123:
2112:Troglitazone
2102:Tesaglitazar
2092:Saroglitazar
2087:Pioglitazone
2057:Muraglitazar
2029:Lanifibranor
1963:
1935:
1828:Volanesorsen
1690:Combinations
1662:inhibitors (
1504:Clinofibrate
1499:Ciprofibrate
1488:
1408:inhibitors (
1375:inhibitors (
1358:Nicofuranose
1309:Rosuvastatin
1299:Pitavastatin
1279:Cerivastatin
1274:Atorvastatin
1075:
1053:
1044:
1035:
1000:
996:
986:
949:
945:
935:
908:
904:
894:
867:
863:
853:
826:
822:
812:
788:(1): 21–27.
785:
781:
771:
751:
744:
727:
716:undergoes a
709:
707:
696:
684:
675:
653:
638:
618:
615:Side-effects
593:
590:Medical uses
585:
573:triglyceride
549:
545:
544:
533:
353:ChEMBL264374
116:Legal status
110:Legal status
2667:Ronifibrate
2657:Farglitazar
2647:Englitazone
2530:Telmisartan
2457:Oxeglitazar
2402:Imiglitazar
2382:Farglitazar
2372:Englitazone
2367:Efatutazone
2347:Ciglitazone
2342:Chiglitazar
2332:Cannabidiol
2327:Bezafibrate
2307:Aleglitazar
2183:Elafibranor
2173:Bezafibrate
2072:Pemafibrate
2019:Gemfibrozil
2009:Fenofibrate
1999:Elafibranor
1969:Chiglitazar
1964:Bezafibrate
1949:Aleglitazar
1849:from market
1808:Policosanol
1783:Lapaquistat
1763:Azacosterol
1640:Bococizumab
1612:Torcetrapib
1607:Obicetrapib
1602:Evacetrapib
1597:Dalcetrapib
1592:Anacetrapib
1544:Ronifibrate
1539:Pemafibrate
1529:Gemfibrozil
1524:Fenofibrate
1489:Bezafibrate
1396:Mitratapide
1386:Dirlotapide
1314:Simvastatin
1304:Pravastatin
1284:Fluvastatin
1234:glucomannan
1201:Colesevelam
864:Circulation
782:Circulation
656:tau protein
649:hepatitis C
647:in an anti-
546:Bezafibrate
460: g·mol
403:100.050.498
333:CHEBI:47612
153:Identifiers
60:MedlinePlus
21:Bezafibrate
2726:Benzamides
2710:Categories
2677:Simfibrate
2652:Etofibrate
2642:Clofibride
2495:Reglitazar
2223:Seladelpar
2188:Fonadelpar
1993:prasterone
1974:Clofibrate
1915:modulators
1823:Triparanol
1798:Mipomersen
1778:Darapladib
1773:Benfluorex
1768:Azalanstat
1677:Evinacumab
1650:Inclisiran
1645:Evolocumab
1635:Alirocumab
1549:Simfibrate
1519:Etofibrate
1514:Clofibride
1509:Clofibrate
1443:Resmetirom
1391:Lomitapide
1353:Niceritrol
1294:Mevastatin
1289:Lovastatin
1211:Colestipol
1206:Colestilan
1169:Hyzetimibe
1081:US 3781328
1059:DE 2149070
736:References
635:Other uses
559:used as a
465:3D model (
453:Molar mass
293:Y9449Q51XH
264:ChemSpider
224:IUPHAR/BPS
188:41859-67-0
179:CAS Number
162:IUPAC name
2629:Agonists:
2603:T-0070907
2427:LG-101506
2422:LG-100754
2417:LG-100268
2397:Ibuprofen
2387:Genistein
2322:Berberine
2279:5-Oxo-ETE
2276:Agonists:
2218:LG-101506
2208:L-165,041
2203:GW-501516
2193:Genistein
2155:Agonists:
2047:LG-100754
2042:LG-101506
2014:Genistein
1979:CP-775146
1936:Agonists:
1859:Phase III
1847:Withdrawn
1534:Nafenopin
1221:Colextran
1174:SCH-48461
1164:Ezetimibe
952:(1): 29.
732:in 1977.
693:Synthesis
663:tauopathy
563:to treat
74:Routes of
46:Drugs.com
2689:See also
2610:Unknown:
2377:Etalocib
2352:Daidzein
2302:15-HpETE
2253:GSK-3787
2248:GSK-0660
2178:Daidzein
2163:15-HpETE
2117:WY-14643
2004:Etomoxir
1984:Daidzein
1944:15-HpETE
1818:Tiadenol
1813:Probucol
1793:Meglutol
1565:GW501516
1476:Fibrates
1338:Acipimox
1230:psyllium
1228:such as
1143:GI tract
1027:22922230
978:22439599
927:16606809
886:15123532
845:15911729
804:10880410
714:tyramine
671:mutation
641:Giaconda
625:myopathy
536:(verify)
244:DrugBank
86:ATC code
2613:SR-1664
2593:GW-9662
2573:MK-0533
2568:INT-131
2563:EPI-001
2549:SPPARMs
2392:GW-1929
2297:15-HETE
2198:GW-0742
2158:15-HETE
2127:GW-6471
2024:GW-7647
1939:15-HETE
1660:ANGPTL3
1257:Statins
1018:3490516
969:3342914
724:History
621:hepatic
575:in the
554:fibrate
550:Bezalip
420:Formula
253:DB01393
199:PubChem
102:)
96: (
94:C10AB02
66:a682711
2598:SR-202
2588:FH-535
2578:S26948
2510:RS5444
2442:nTZDpa
2243:FH-535
2132:MK-886
1842:WHO-EM
1558:Others
1431:(VLDL)
1348:Niacin
1188:resins
1156:NPC1L1
1090:
1068:
1025:
1015:
976:
966:
925:
884:
843:
802:
759:
491:SMILES
458:361.82
344:ChEMBL
313:D01366
144:℞-only
142:
129:
2558:BADGE
2264:PPARγ
2143:PPARδ
1924:PPARα
1751:Other
1468:(LDL)
1248:Liver
687:PPARα
577:blood
511:InChI
467:JSmol
324:ChEBI
273:35728
213:39042
1989:DHEA
1908:PPAR
1377:VLDL
1373:MTTP
1327:and
1232:and
1023:PMID
974:PMID
923:PMID
882:PMID
841:PMID
800:PMID
757:ISBN
708:The
608:HOMA
571:and
557:drug
304:KEGG
284:UNII
233:2668
80:Oral
42:AHFS
1668:HDL
1664:LDL
1626:LDL
1583:HDL
1410:LDL
1329:LDL
1325:HDL
1265:LDL
1192:LDL
1134:C10
1013:PMC
1005:doi
964:PMC
954:doi
913:doi
909:166
872:doi
868:109
831:doi
827:165
790:doi
786:102
665:in
581:HDL
369:EPA
203:CID
131:POM
99:WHO
2712::
1855::
1263:,
1154:,
1043:.
1021:.
1011:.
1001:21
999:.
995:.
972:.
962:.
950:11
948:.
944:.
921:.
907:.
903:.
880:.
866:.
862:.
839:.
825:.
821:.
798:.
784:.
780:.
673:.
583:.
437:Cl
434:20
428:19
138:US
125:UK
2555::
2484:2
2291:2
2036:4
1991:(
1899:e
1892:t
1885:v
1670:)
1666:/
1628:)
1624:(
1585:)
1581:(
1412:)
1379:)
1331:)
1267:)
1259:(
1194:)
1190:(
1186:/
1136:)
1132:(
1122:e
1115:t
1108:v
1029:.
1007::
980:.
956::
929:.
915::
888:.
874::
847:.
833::
806:.
792::
765:.
710:p
469:)
446:4
443:O
440:N
431:H
425:C
371:)
367:(
140::
127::
44:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
