Knowledge

Biliatresone

Source 📝

191: 24: 305: 92: 312: 230: 205: 319: 214:
InChI=1S/C18H16O6/c1-10(11-6-4-5-7-12(11)19)16(20)15-13(21-2)8-14-17(18(15)22-3)24-9-23-14/h4-8,19H,1,9H2,2-3H3
169: 612: 186: 549:"Reactivity of biliatresone, a natural biliary toxin, with glutathione, histamine, and amino acids" 602: 132: 68: 36: 504:
Patman, G. (2015). "Biliary tract: Newly identified biliatresone causes biliary atresia".
190: 8: 112: 58: 573: 548: 529: 481: 448: 424: 399: 157: 578: 533: 521: 486: 429: 340: 617: 607: 568: 564: 560: 513: 476: 472: 468: 419: 411: 374: 253: 415: 350: 362: 296: 596: 517: 582: 525: 490: 433: 335: 361:
moiety of biliatresone is particularly reactive, being enhanced by the
281: 123: 354: 400:"Identification of a plant isoflavonoid that causes biliary atresia" 295:
Except where otherwise noted, data are given for materials in their
378: 370: 91: 366: 144: 23: 358: 103: 81: 174: 334:
is an example of a very rare type of a naturally occurring
45:-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)prop-2-en-1-one 457:: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone" 594: 238:O=C(C(C1=C(O)C=CC=C1)=C)C2=C(OC)C3=C(OCO3)C=C2OC 156: 67: 449:"Biliatresone, a Reactive Natural Toxin from 349:. It has been found to cause extrahepatic 189: 131: 572: 480: 423: 338:-related 1,2-diaryl-2-propenone found in 185: 595: 503: 397: 217:Key: SIKIIXNKUAAGAM-UHFFFAOYSA-N 111: 398:Lorent, K.; et al. (May 2015). 546: 447:Koo, K.A.; et al. (Aug 2015). 446: 147: 13: 14: 629: 303: 265: 22: 547:Koo, K.A.; et al. (2016). 299:(at 25 °C , 100 kPa). 565:10.1021/acs.chemrestox.5b00308 540: 497: 473:10.1021/acs.chemrestox.5b00227 440: 391: 271: 259: 1: 506:Nat Rev Gastroenterol Hepatol 384: 416:10.1126/scitranslmed.aaa1652 373:groups, and undergoes ready 7: 10: 634: 293: 246: 226: 201: 51: 35: 30: 21: 518:10.1038/nrgastro.2015.91 451:Dysphania glomulifera 37:Preferred IUPAC name 289: g·mol 18: 553:Chem. Res. Toxicol 320:Infobox references 41:1-(4,6-Dimethoxy-2 16: 613:Methoxy compounds 328:Chemical compound 326: 325: 170:CompTox Dashboard 93:Interactive image 625: 587: 586: 576: 544: 538: 537: 501: 495: 494: 484: 467:(8): 1519–1521. 461:Chem Res Toxicol 444: 438: 437: 427: 410:(286): 286ra67. 395: 375:Michael addition 310: 307: 306: 288: 273: 267: 261: 254:Chemical formula 194: 193: 178: 176: 160: 149: 135: 115: 95: 71: 26: 19: 15: 633: 632: 628: 627: 626: 624: 623: 622: 593: 592: 591: 590: 545: 541: 502: 498: 445: 441: 396: 392: 387: 351:biliary atresia 329: 322: 317: 316: 315:  ?) 308: 304: 300: 286: 276: 270: 264: 256: 242: 239: 234: 233: 222: 219: 218: 215: 209: 208: 197: 187:DTXSID901046375 179: 172: 163: 150: 138: 118: 98: 85: 74: 61: 47: 46: 12: 11: 5: 631: 621: 620: 615: 610: 605: 589: 588: 539: 496: 439: 404:Sci Transl Med 389: 388: 386: 383: 363:methylenedioxy 327: 324: 323: 318: 302: 301: 297:standard state 294: 291: 290: 284: 278: 277: 274: 268: 262: 257: 252: 249: 248: 244: 243: 241: 240: 237: 229: 228: 227: 224: 223: 221: 220: 216: 213: 212: 204: 203: 202: 199: 198: 196: 195: 182: 180: 168: 165: 164: 162: 161: 153: 151: 143: 140: 139: 137: 136: 128: 126: 120: 119: 117: 116: 108: 106: 100: 99: 97: 96: 88: 86: 79: 76: 75: 73: 72: 64: 62: 57: 54: 53: 49: 48: 40: 39: 33: 32: 28: 27: 9: 6: 4: 3: 2: 630: 619: 616: 614: 611: 609: 606: 604: 603:Benzodioxoles 601: 600: 598: 584: 580: 575: 570: 566: 562: 558: 554: 550: 543: 535: 531: 527: 523: 519: 515: 511: 507: 500: 492: 488: 483: 478: 474: 470: 466: 462: 458: 456: 455:D. littoralis 452: 443: 435: 431: 426: 421: 417: 413: 409: 405: 401: 394: 390: 382: 380: 377:of water and 376: 372: 368: 364: 360: 356: 352: 348: 347:D. littoralis 344: 342: 337: 333: 321: 314: 298: 292: 285: 283: 280: 279: 258: 255: 251: 250: 245: 236: 235: 232: 225: 211: 210: 207: 200: 192: 188: 184: 183: 181: 171: 167: 166: 159: 155: 154: 152: 146: 142: 141: 134: 130: 129: 127: 125: 122: 121: 114: 110: 109: 107: 105: 102: 101: 94: 90: 89: 87: 83: 78: 77: 70: 66: 65: 63: 60: 56: 55: 50: 44: 38: 34: 29: 25: 20: 17:Biliatresone 559:(2): 142–9. 556: 552: 542: 509: 505: 499: 464: 460: 454: 450: 442: 407: 403: 393: 346: 339: 336:isoflavonoid 332:Biliatresone 331: 330: 113:CHEBI:131631 69:1801433-90-8 52:Identifiers 42: 357:model. The 343:glomulifera 247:Properties 597:Categories 512:(7): 369. 385:References 282:Molar mass 124:ChemSpider 80:3D model ( 59:CAS Number 534:205488639 355:zebrafish 341:Dysphania 158:124079379 583:26713899 526:26008130 491:26175131 434:25947162 379:methanol 133:58827638 618:Ketones 608:Phenols 574:4757443 482:4755499 425:4784984 371:hydroxy 367:methoxy 313:what is 311: ( 287:328.320 145:PubChem 581:  571:  532:  524:  489:  479:  432:  422:  231:SMILES 31:Names 530:S2CID 359:enone 353:in a 206:InChI 104:ChEBI 82:JSmol 579:PMID 522:PMID 487:PMID 453:and 430:PMID 369:and 345:and 569:PMC 561:doi 514:doi 477:PMC 469:doi 420:PMC 412:doi 175:EPA 148:CID 599:: 577:. 567:. 557:29 555:. 551:. 528:. 520:. 510:12 508:. 485:. 475:. 465:28 463:. 459:. 428:. 418:. 406:. 402:. 381:. 365:, 269:16 263:18 585:. 563:: 536:. 516:: 493:. 471:: 436:. 414:: 408:7 309:N 275:6 272:O 266:H 260:C 177:) 173:( 84:) 43:H

Index


Preferred IUPAC name
CAS Number
1801433-90-8
JSmol
Interactive image
ChEBI
CHEBI:131631
ChemSpider
58827638
PubChem
124079379
CompTox Dashboard
DTXSID901046375
Edit this at Wikidata
InChI
SMILES
Chemical formula
Molar mass
standard state
what is
Infobox references
isoflavonoid
Dysphania
biliary atresia
zebrafish
enone
methylenedioxy
methoxy
hydroxy

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.