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Biostatistics

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2157:. While QTL mapping is limited due resolution, GWAS does not have enough power when rare variants of small effect that are also influenced by environment. So, the concept of Genomic Selection (GS) arises in order to use all molecular markers in the selection and allow the prediction of the performance of candidates in this selection. The proposal is to genotype and phenotype a training population, develop a model that can obtain the genomic estimated breeding values (GEBVs) of individuals belonging to a genotype and but not phenotype population, called testing population. This kind of study could also include a validation population, thinking in the concept of 6611: 659:. However, pest and disease injuries in plats are obtained by observation, considering score scales for levels of damage. Especially, in genetic studies, modern methods for data collection in field and laboratory should be considered, as high-throughput platforms for phenotyping and genotyping. These tools allow bigger experiments, while turn possible evaluate many plots in lower time than a human-based only method for data collection. Finally, all data collected of interest must be stored in an organized data frame for further analysis. 946: 1449: 1863:(GSEA) considers the perturbation of whole (functionally related) gene sets rather than of single genes. These gene sets might be known biochemical pathways or otherwise functionally related genes. The advantage of this approach is that it is more robust: It is more likely that a single gene is found to be falsely perturbed than it is that a whole pathway is falsely perturbed. Furthermore, one can integrate the accumulated knowledge about biochemical pathways (like the 8282: 6597: 1831:(for proteomics) generate enormous amounts of data, allowing many tests to be performed simultaneously. Careful analysis with biostatistical methods is required to separate the signal from the noise. For example, a microarray could be used to measure many thousands of genes simultaneously, determining which of them have different expression in diseased cells compared to normal cells. However, only a fraction of genes will be differentially expressed. 1742: 8306: 6635: 8294: 6623: 4287: 2214:, demands comparison of conditions. The goal is to identify genes which have a significant change in abundance between different conditions. Then, experiments are designed appropriately, with replicates for each condition/treatment, randomization and blocking, when necessary. In RNA-Seq, the quantification of expression uses the information of mapped reads that are summarized in some genetic unit, as 1998: 1709:
practice, then the null may be frequently rejected even if the main hypothesis is true. Such rejections are said to be due to model mis-specification. Verifying whether the outcome of a statistical test does not change when the technical assumptions are slightly altered (so-called robustness checks) is the main way of combating mis-specification.
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and a biostatistics program is twofold: (i) statistics departments will often host theoretical/methodological research which are less common in biostatistics programs and (ii) statistics departments have lines of research that may include biomedical applications but also other areas such as industry (
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However, QTL mapping resolution is impaired by the amount of recombination assayed, a problem for species in which it is difficult to obtain large offspring. Furthermore, allele diversity is restricted to individuals originated from contrasting parents, which limit studies of allele diversity when we
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do not work well for high dimensional data (i.e. when the number of observations n is smaller than the number of features or predictors p: n < p). As a matter of fact, one can get quite high R-values despite very low predictive power of the statistical model. These classical statistical techniques
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about an unknown population, by estimation and/or hypothesis testing. In other words, it is desirable to obtain parameters to describe the population of interest, but since the data is limited, it is necessary to make use of a representative sample in order to estimate them. With that, it is possible
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as well as bioinformatics. In larger universities around the world, where both a statistics and a biostatistics department exist, the degree of integration between the two departments may range from the bare minimum to very close collaboration. In general, the difference between a statistics program
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levels), the information of one predictor might be contained in another one. It could be that only 5% of the predictors are responsible for 90% of the variability of the response. In such a case, one could apply the biostatistical technique of dimension reduction (for example via principal component
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The main hypothesis being tested (e.g., no association between treatments and outcomes) is often accompanied by other technical assumptions (e.g., about the form of the probability distribution of the outcomes) that are also part of the null hypothesis. When the technical assumptions are violated in
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language maintained by CRAN. In addition to its functions to read data tables, take descriptive statistics, develop and evaluate models, its repository contains packages developed by researchers around the world. This allows the development of functions written to deal with the statistical analysis
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genetic and molecular database – TAIR. Phytozome, in turn, stores the assemblies and annotation files of dozen of plant genomes, also containing visualization and analysis tools. Moreover, there is an interconnection between some databases in the information exchange/sharing and a major initiative
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is a mathematical diagram that uses Cartesian coordinates to display values of a dataset. A scatter plot shows the data as a set of points, each one presenting the value of one variable determining the position on the horizontal axis and another variable on the vertical axis. They are also called
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A confidence interval is a range of values that can contain the true real parameter value in given a certain level of confidence. The first step is to estimate the best-unbiased estimate of the population parameter. The upper value of the interval is obtained by the sum of this estimate with the
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Crossa, José; Pérez-Rodríguez, Paulino; Cuevas, Jaime; Montesinos-López, Osval; Jarquín, Diego; De Los Campos, Gustavo; Burgueño, Juan; Gonzålez-Camacho, Juan M; Pérez-Elizalde, Sergio; Beyene, Yoseph; Dreisigacker, Susanne; Singh, Ravi; Zhang, Xuecai; Gowda, Manje; Roorkiwal, Manish; Rutkoski,
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PLA 3.0: Is a biostatistical analysis software for regulated environments (e.g. drug testing) which supports Quantitative Response Assays (Parallel-Line, Parallel-Logistics, Slope-Ratio) and Dichotomous Assays (Quantal Response, Binary Assays). It also supports weighting methods for combination
1900:). In addition to databases that contain specific molecular information, there are others that are ample in the sense that they store information about an organism or group of organisms. As an example of a database directed towards just one organism, but that contains much data about it, is the 1855:
linear regression) were developed for low dimensional data (i.e. where the number of observations n is much larger than the number of predictors p: n >> p). In cases of high dimensionality, one should always consider an independent validation test set and the corresponding residual sum of
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started the genetics studies investigating genetics segregation patterns in families of peas and used statistics to explain the collected data. In the early 1900s, after the rediscovery of Mendel's Mendelian inheritance work, there were gaps in understanding between genetics and evolutionary
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defines an acceptable global significance level, denoted by α* and each test is individually compared with a value of α = α*/m. This ensures that the familywise error rate in all m tests, is less than or equal to α*. When m is large, the Bonferroni correction may be overly conservative. An
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enables storage and management of biological data with the possibility of ensuring access for users around the world. They are useful for researchers depositing data, retrieve information and files (raw or processed) originated from other experiments or indexing scientific articles, as
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Recent developments have made a large impact on biostatistics. Two important changes have been the ability to collect data on a high-throughput scale, and the ability to perform much more complex analysis using computational techniques. This comes from the development in areas as
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The research question will define the objective of a study. The research will be headed by the question, so it needs to be concise, at the same time it is focused on interesting and novel topics that may improve science and knowledge and that field. To define the way to ask the
1984:. Random forest techniques generate a panel of decision trees. Decision trees have the advantage that you can draw them and interpret them (even with a basic understanding of mathematics and statistics). Random Forests have thus been used for clinical decision support systems. 1956:
Collaborative work among molecular biologists, bioinformaticians, statisticians and computer scientists is important to perform an experiment correctly, going from planning, passing through data generation and analysis, and ending with biological interpretation of the results.
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CycDesigN: A computer package developed by VSNi that helps the researchers create experimental designs and analyze data coming from a design present in one of three classes handled by CycDesigN. These classes are resolvable, non-resolvable, partially replicated and
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There are a lot of tools that can be used to do statistical analysis in biological data. Most of them are useful in other areas of knowledge, covering a large number of applications (alphabetical). Here are brief descriptions of some of them:
118:. Later, biometricians could not reproduce Galton conclusions in different experiments, and Mendel's ideas prevailed. By the 1930s, models built on statistical reasoning had helped to resolve these differences and to produce the neo-Darwinian 338:) and is usually based on a permanent knowledge about the topic or an obvious occurrence of the phenomena, sustained by a deep literature review. We can say it is the standard expected answer for the data under the situation in 987:
is a graph that shows categorical data as bars presenting heights (vertical bar) or widths (horizontal bar) proportional to represent values. Bar charts provide an image that could also be represented in a tabular format.
2106:. In other words, it is desirable to discover the genetic basis of a measurable trait, a quantitative trait, that is under polygenic control. A genome region that is responsible for a continuous trait is called a 80:
studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even contributed with statistical advances with the development of methods and tools.
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Benjamini, Y. & Hochberg, Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society. Series B (Methodological) 57, 289–300
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In the United States, where several universities have dedicated biostatistics departments, many other top-tier universities integrate biostatistics faculty into statistics or other departments, such as
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tried to expand Mendel's discoveries with human data and proposed a different model with fractions of the heredity coming from each ancestral composing an infinite series. He called this the theory of "
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represent the variation of a value over another metric, such as time. In general, values are represented in the vertical axis, while the time variation is represented in the horizontal axis.
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Despite the fundamental importance and frequent necessity of statistical reasoning, there may nonetheless have been a tendency among biologists to distrust or deprecate results which are not
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is a method for graphically depicting groups of numerical data. The maximum and minimum values are represented by the lines, and the interquartile range (IQR) represent 25–75% of the data.
796: 2487:. Thus, departments carrying the name "biostatistics" may exist under quite different structures. For instance, relatively new biostatistics departments have been founded with a focus on 1884:. Another possibility is search for the desired term (a gene, a protein, a disease, an organism, and so on) and check all results related to this search. There are databases dedicated to 1515:
Hypothesis testing is essential to make inferences about populations aiming to answer research questions, as settled in "Research planning" section. Authors defined four steps to be set:
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Subramanian, A.; Tamayo, P.; Mootha, V. K.; Mukherjee, S.; Ebert, B. L.; Gillette, M. A.; Paulovich, A.; Pomeroy, S. L.; Golub, T. R.; Lander, E. S.; Mesirov, J. P. (30 September 2005).
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Although correlations between two different kinds of data could be inferred by graphs, such as scatter plot, it is necessary validate this though numerical information. For this reason,
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level. They are most often found in schools of public health, affiliated with schools of medicine, forestry, or agriculture, or as a focus of application in departments of statistics.
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and the research plan will reduce errors while taking a decision in understanding a phenomenon. The research plan might include the research question, the hypothesis to be tested, the
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are used to perform the tests for statistical significance and as the number of genes is high, multiple tests correction have to be considered. Some examples of other analysis on
358:. It assumes some degree of association between the treatment and the outcome. Although, the hypothesis is sustained by question research and its expected and unexpected answers. 125:
Solving these differences also allowed to define the concept of population genetics and brought together genetics and evolution. The three leading figures in the establishment of
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Szczech, Lynda Anne; Coladonato, Joseph A.; Owen, William F. (4 October 2002). "Key Concepts in Biostatistics: Using Statistics to Answer the Question "Is There a Difference?"".
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multiplication between the standard error of the mean and the confidence level. The calculation of lower value is similar, but instead of a sum, a subtraction must be applied.
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As an example, consider groups of similar animals (mice, for example) under two different diet systems. The research question would be: what is the best diet? In this case, H
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Nowadays, increase in size and complexity of molecular datasets leads to use of powerful statistical methods provided by computer science algorithms which are developed by
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one, but it underestimate the sample error, leading to false positives. Currently, biological variation is considered by methods that estimate a dispersion parameter of a
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of data that comes from specific applications. In the case of Bioinformatics, for example, there are packages located in the main repository (CRAN) and in others, as
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Nizamuddin, Sarah L.; Nizamuddin, Junaid; Mueller, Ariel; Ramakrishna, Harish; Shahul, Sajid S. (October 2017). "Developing a Hypothesis and Statistical Planning".
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based on linkage have to be built. Some of the best-known QTL mapping algorithms are Interval Mapping, Composite Interval Mapping, and Multiple Interval Mapping.
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On the other hand, the advent of modern computer technology and relatively cheap computing resources have enabled computer-intensive biostatistical methods like
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In the bar chart example, we have the birth rate in Brazil for the December months from 2010 to 2016. The sharp fall in December 2016 reflects the outbreak of
440:, in a specific area at a given time. In biostatistics, this concept is extended to a variety of collections possible of study. Although, in biostatistics, a 1687:
increase and some strategy are used to control this occurrence. This is commonly achieved by using a more stringent threshold to reject null hypotheses. The
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results can be approximated by a normal distribution, RNA-Seq counts data are better explained by other distributions. The first used distribution was the
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area. Therefore, data mining and machine learning allow detection of patterns in data with a complex structure, as biological ones, by using methods of
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table, which consists of data arranged in rows and columns, where the frequency is the number of occurrences or repetitions of data. Frequency can be:
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Sandelowski, Margarete (2000). "Combining Qualitative and Quantitative Sampling, Data Collection, and Analysis Techniques in Mixed-Method Studies".
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worked alongside statistician Betty Allan developing several basic statistical methods in support of his work studying the crop experiments at
6673: 6237: 2348:: A programming interface for high-level data processing, data mining and data visualization. Include tools for gene expression and genomics. 148:(1930), as well as Allan's scientific papers. Fisher went on to give many contributions to genetics and statistics. Some of them include the 2330:(REML). Models with fixed effects and random effects and nested or crossed ones are allowed. Gives the possibility to investigate different 6387: 479:
is defined as to randomly get a representative part of the entire population, to make posterior inferences about the population. So, the
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and measuring traits in populations, but their mapping needs the obtaining of a population from an experimental crossing, like an F2 or
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Data collection methods must be considered in research planning, because it highly influences the sample size and experimental design.
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Once the aim of the study is defined, the possible answers to the research question can be proposed, transforming this question into a
2377:: A data analysis software widely used, going through universities, services and industry. Developed by a company with the same name ( 7139: 145: 289:
perspectives and costs involved. It is essential to carry the study based on the three basic principles of experimental statistics:
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denoted by α is the type I error rate and should be chosen before performing the test. The type II error rate is denoted by ÎČ and
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can be more than one hypothesis. It can assume not only differences across observed parameters, but their degree of differences (
168:. He is credited for the sentence "Natural selection is a mechanism for generating an exceedingly high degree of improbability". 8137: 7453: 808: 8195: 8102: 7134: 3899: 3859: 2954: 3102:"Essentials of Biostatistics in Public Health & Essentials of Biostatistics Workbook: Statistical Computing Using Excel" 2697: 8185: 6938: 4647: 4347: 2862: 2595: 3954:
Piepho, Hans-Peter; Williams, Emlyn R; Michel, Volker (2015). "Beyond Latin Squares: A Brief Tour of Row-Column Designs".
30:"Biometry" redirects here. For the automated recognition of people based on intrinsic physical or behavioural traits, see 8142: 7706: 7294: 5251: 4399: 4303: 2207: 1681: 1625: 1618: 1896:) and the description of gene function classifying it by cellular component, molecular function and biological process ( 7210: 3061: 3028: 2521: 1808: 1071: 4320: 2075:. As one example, there is the assessment of severity state of a patient with a prognosis of an outcome of a disease. 1837:
often occurs in high-throughput biostatistical settings. Due to high intercorrelation between the predictors (such as
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environment and programming language dedicated to statistical computing and graphics. It is an implementation of
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is defined by the researcher, according to his/her interests in answering the main question. Besides that, the
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just means that there is not enough evidence to support its rejection, but not that this hypothesis is true.
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is the probability of obtaining results as extreme as or more extreme than those observed, assuming the
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is a measure of association between two variables, X and Y. This coefficient, usually represented by
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Zeng, Zhao-Bang (2005). "QTL mapping and the genetic basis of adaptation: Recent developments".
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is determined by several things, since the scope of the research to the resources available. In
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to test previously defined hypotheses and apply the conclusions to the entire population. The
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are required. They provide a numerical value that reflects the strength of an association.
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Efron, Bradley (February 2008). "Microarrays, Empirical Bayes and the Two-Groups Model".
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Often, it is useful to pool information from multiple predictors together. For example,
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Biostatistical modeling forms an important part of numerous modern biological theories.
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In agriculture and biology studies, yield data and its components can be obtained by
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have a panel of individuals representing a natural population. For this reason, the
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aiming for breeding, mainly the molecular ones, collaborated to the development of
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With new technologies and genetics knowledge, biostatistics are now also used for
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Scatter diagram that demonstrates the Pearson correlation for different values of
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representation, such as line charts, bar charts, histograms, scatter plot. Also,
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Bioinformatics advances in databases, data mining, and biological interpretation
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Overholser, Brian R; Sowinski, Kevin M (2017). "Biostatistics Primer: Part I".
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squares (RSS) and R of the validation test set, not those of the training set.
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In multiple tests of the same hypothesis, the probability of the occurrence of
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As a summary, some points about the application of quantitative genetics are:
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can be very useful to describe an overview of the data. Follow some examples:
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is not only the individuals, but the total of one specific component of their
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and this synthesis all relied on statistics and developed its use in biology.
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Matthias Dehmer; Frank Emmert-Streib; Armin Graber; Armindo Salvador (2011).
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When testing a hypothesis, there are two types of statistic errors possible:
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are usually smaller than in other biological studies, and in most cases, the
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is compared with it. So, α also has to be predefined before the experiment.
1030: 1018: 652:, collection is done by measuring numerical information using instruments. 242: 175: 107: 3975: 3481: 2615:
Centre for Transformative Innovation, Swinburne University of Technology.
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calculations and the automatic data aggregation of independent assay data.
2342:. It includes less used designs the Latinized ones, as t-Latinized design. 1572:
is rejected or not rejected, based on the evidence that the comparison of
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Introduction to Biostatistics. A Guide to Design, Analysis, and Discovery
2404: 2355: 2211: 590:", "augmented blocks", and many others. All of the designs might include 551: 496: 488: 460: 385:
would be that the diets have different effects over animals metabolism (H
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Zhu, Chengsong; Gore, Michael; Buckler, Edward S; Yu, Jianming (2008).
2239: 2219: 1766: in this section. Unsourced material may be challenged and removed. 992: 972: 587: 535: 464: 441: 433: 429: 421: 401: 366: 339: 327: 274: 216: 60: 52: 31: 6651: 3629:"The advantages and limitations of trait analysis with GWAS: A review" 3396: 3379: 3288: 2718: 314:
might be necessary. So the research can be useful to add value to the
269:
we might have. To answer this question with a high certainty, we need
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Usually, a study aims to understand an effect of a phenomenon over a
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contents, it's important to consider the design and analysis of the
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In biomedical research, this work can assist in finding candidates
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would be that there is no difference between the two diets in mice
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Applied Statistics for Network Biology: Methods in Systems Biology
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10.1002/1098-240X(200006)23:3<246::AID-NUR9>3.0.CO;2-H
2495:, whereas older departments, typically affiliated with schools of 526:. There are three basic experimental designs to randomly allocate 7510: 7113: 6843: 6713: 6574: 6275: 2251: 2203: 1653: 1573: 1425: 712:: represents the number of times that a determined value appear; 567: 531: 456:, for animals, or the total leaf area, for a plant, for example. 437: 425: 246: 153: 56: 7150: 3517: 3309: 2614: 1534:. But they must be defined before the experiment implementation. 230:
also helped to add quantitative discipline to biological study.
222:
In parallel to this overall development, the pioneering work of
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is a measure of variability that is crucial to do inferences.
55:
that applies statistical methods to a wide range of topics in
7967: 4325: 2433: 2427: 2422: 1889: 683: 149: 4204:"Statistical Applications in Genetics and Molecular Biology" 3837:
Microarray Gene Expression Data Analysis: A Beginner's Guide
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Oshlack, Alicia; Robinson, Mark D; Young, Matthew D (2010).
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Committee on the Environment, Public Health and Food Safety
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models are examples of common machine learning algorithms.
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analysis). Classical statistical techniques like linear or
1720:
will select or model that more approximate true model. The
1696:. The FDR controls the expected proportion of the rejected 1692:
alternative to the Bonferroni correction is to control the
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Application of statistical techniques to biological systems
3918: 2551:
Statistical Applications in Genetics and Molecular Biology
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Almost all educational programmes in biostatistics are at
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experiments. Often concerning diseases or disease stages.
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that can cause or influence predisposition to diseases in
1911:(INSDC) which relates data from DDBJ, EMBL-EBI, and NCBI. 1703: 617:
effect can be controlled or measured. It is common to use
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into a consistent, coherent whole that could begin to be
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International Nucleotide Sequence Database Collaboration
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and α brings. It is pointed that the failure to reject H
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In the next example, we have the number of genes in ten
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Statistical Analysis of Gene Expression Microarray Data
3771:"From RNA-seq reads to differential expression results" 3680:"Status and Prospects of Association Mapping in Plants" 2118:/lines (RILs). To scan for QTLs regions in a genome, a 1470:
for the sample, assumes values between −1 and 1, where
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is the value of a set of data that appears most often.
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Biostatistics explored through R software: An overview
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Statistical Methods in Bioinformatics: An Introduction
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Helen Causton; John Quackenbush; Alvis Brazma (2003).
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Data collection varies according to type of data. For
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for the December months from 2010 to 2016; Figure C:
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Autoregressive conditional heteroskedasticity (ARCH)
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This has been used in agriculture to improve crops (
1621:
is the incorrect rejection of a true null hypothesis
1548:
that determines the statistical significance when a
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Australian and New Zealand Journal of Public Health
3023:(3rd ed.). Belmont, CA: Thomson, Brooks/Cole. 1728:are examples of asymptotically efficient criteria. 662: 558:is the root of a good study and the arrangement of 5700: 2925:DATASUS: Tecnologia da Informação a Serviço do SUS 2760: 2202:Studies for differential expression of genes from 2110:(QTL). The study of QTLs become feasible by using 2067:and health care policy & management. In these 1980:have gained popularity as a method for performing 1443: 1298: 1156: 1134: 953:. The birth rate in Brazil (2010–2016); Figure B: 844: 790: 2721:Journal of Cardiothoracic and Vascular Anesthesia 2688: 1135:{\displaystyle {x_{1}+x_{2}+x_{3}+\cdots +x_{n}}} 8324: 4304:The Collection of Biostatistics Research Archive 3677: 2269:for gene network inference or pathways analysis. 2130:was proposed in order to identify QTLs based on 5786:Multivariate adaptive regression splines (MARS) 3518:"National Center for Biotechnology Information" 3316:Proceedings of the National Academy of Sciences 2413:image analysis, deep-learning, machine-learning 1474:= 1 represents a perfect positive correlation, 4038:PLA 3.0 – Software for Biostatistical Analysis 2470: 1814: 1600: 594:, determined by the researcher, to provide an 7166: 6667: 4341: 4186:"Communications in Biometry and Crop Science" 4006: 3850:Frank Emmert-Streib; Matthias Dehmer (2010). 1595: 791:{\displaystyle N=f_{1}+f_{2}+f_{3}+...+f_{n}} 71: 4076:"The International Journal of Biostatistics" 2944: 1731: 273:results. The correct definition of the main 3834: 3626: 2945:Forthofer, Ronald N.; Lee, Eun Sul (1995). 2838: 2548:Communications in Biometry and Crop Science 1712: 1431: 1369:( 2 + 3 + 3 + 3 + 3 + 3 + 4 + 4 + 11 ) / 9 8128:Centers for Disease Control and Prevention 7173: 7159: 6674: 6660: 4386: 4348: 4334: 3875:Warren J. Ewens; Gregory R. Grant (2004). 3852:Medical Biostatistics for Complex Diseases 2512:and biological areas other than medicine. 1934:, among others. To indicate some of them, 621:, where results are usually compared with 181:and methods of computing them and defined 59:. It encompasses the design of biological 8088:Centre for Disease Prevention and Control 8078:Center for Disease Control and Prevention 7140:Timeline of biology and organic chemistry 4999: 4309:Guide to Biostatistics (MedPageToday.com) 4222:"Statistical Methods in Medical Research" 3796: 3786: 3695: 3654: 3644: 3560: 3395: 3345: 3335: 3278: 3241: 3166: 3117: 2995: 2852: 2665: 2533:Journal of Epidemiology and Biostatistics 1782:Learn how and when to remove this message 1485: 1324:is the value in the middle of a dataset. 146:The Genetical Theory of Natural Selection 4031: 3534: 3084: 2085: 1961:Use of computationally intensive methods 1447: 1002: 944: 845:{\displaystyle n_{i}={\frac {f_{i}}{N}}} 321: 142:Statistical Methods for Research Workers 94:". His ideas were strongly disagreed by 8133:Health departments in the United States 6681: 3913: 3911: 3524:. U. S. National Library of Medicine –. 3224:Hayden, Erika Check (8 February 2012). 3051: 2969: 2554:Statistical Methods in Medical Research 2515: 1704:Mis-specification and robustness checks 14: 8325: 8138:Council on Education for Public Health 6312:Kaplan–Meier estimator (product limit) 3627:Korte, Arthur; Farlow, Ashley (2013). 3223: 3099: 2639: 2530:International Journal of Biostatistics 1530:), that is going to be tested, and an 1346:Comparison among mean, median and mode 1068:is the sum of a collection of values ( 562:within the study is essential because 514: 8196:Professional degrees of public health 8103:Ministry of Health and Family Welfare 7154: 7135:Nobel Prize in Physiology or Medicine 6655: 6385: 5952: 5699: 4998: 4768: 4385: 4329: 3990:"The Comprehensive R Archive Network" 3541:Experimental & Molecular Medicine 3377: 3373: 3371: 3369: 3367: 3365: 3264: 3140: 2940: 2938: 2936: 2934: 2218:that are part of a gene sequence. As 619:randomized controlled clinical trials 8293: 8186:Bachelor of Science in Public Health 6622: 6322:Accelerated failure time (AFT) model 3908: 3712:Jessica; Varshney, Rajeev K (2017). 3583: 3535:Apweiler, Rolf; et al. (2018). 3018: 2915: 2913: 2756: 2754: 2752: 2750: 2714: 2712: 2710: 2596:Mathematical and theoretical biology 1991: 1945:are examples of cluster algorithms; 1764:adding citations to reliable sources 1735: 1726:Bayesian Information Criterion (BIC) 1722:Akaike's Information Criterion (AIC) 1538:Significance level and decision rule 667: 300: 256: 8305: 7454:Workers' right to access the toilet 7295:Human right to water and sanitation 6634: 5917:Analysis of variance (ANOVA, anova) 4769: 4299:The International Biometric Society 4090:"PubMed Journals will be shut down" 3226:"Biostatistics: Revealing analysis" 3056:. Dubuque, Iowa: Wm. C. Brown Pub. 1675: 1556:Experiment and statistical analysis 697: 24: 6012:Cochran–Mantel–Haenszel statistics 4638:Pearson product-moment correlation 3362: 2931: 2640:Gunter, Chris (10 December 2008). 2197: 1809:Machine learning in bioinformatics 636: 522:sustain those basic principles of 203:These and other biostatisticians, 25: 8349: 7727:Commercial determinants of health 7180: 4280: 4058:"Biostatistics - Oxford Academic" 2910: 2891: 2747: 2707: 1819:New biomedical technologies like 1628:is the failure to reject a false 1540:: A decision rule depends on the 237:apparent. One anecdote describes 8304: 8292: 8281: 8280: 7310:National public health institute 6633: 6621: 6609: 6596: 6595: 6386: 4285: 4032:Stegmann, Dr Ralf (2019-07-01). 3758:from the original on 2022-10-09. 3119:10.1111/j.1753-6405.2009.00372.x 2841:Research in Nursing & Health 2810:10.1046/j.1525-139X.2002.00085.x 2703:from the original on 2022-10-09. 2689:Charles T. Munger (2003-10-03). 2245: 2043: 1996: 1740: 1348:Values = { 2,3,3,3,3,3,4,4,11 } 678:Data can be represented through 663:Analysis and data interpretation 7707:Open-source healthcare software 7449:Sociology of health and illness 6271:Least-squares spectral analysis 4250: 4232: 4214: 4196: 4178: 4152: 4134: 4108: 4096: 4082: 4068: 4050: 4025: 4000: 3982: 3947: 3937:"CycDesigN - VSN International" 3929: 3883: 3868: 3843: 3828: 3813: 3762: 3704: 3697:10.3835/plantgenome2008.02.0089 3671: 3620: 3577: 3528: 3510: 3492: 3474: 3456: 3438: 3420: 3303: 3258: 3217: 3193: 3183: 3134: 3093: 3078: 3045: 3012: 2963: 2536:Biostatistics and Public Health 1987: 1751:needs additional citations for 1460:Pearson correlation coefficient 1444:Pearson correlation coefficient 1024: 507:is a key in determining sample 459:It is not possible to take the 346:assumes no association between 8068:Caribbean Public Health Agency 7880:Sexually transmitted infection 7777:Statistical hypothesis testing 7538:Occupational safety and health 7439:Sexual and reproductive health 7352:Occupational safety and health 5252:Mean-unbiased minimum-variance 4355: 4142:"Biometrika - Oxford Academic" 4011:. Vinaitheerthan Renganathan. 3384:Journal of Cellular Physiology 2885: 2832: 2789: 2763:Nutrition in Clinical Practice 2682: 2633: 2608: 2522:List of biostatistics journals 2275:and pharmaceutical development 2238:data comes from microarray or 2228:negative binomial distribution 2098:in order to link variation in 2011:format but may read better as 1482:= 0 is no linear correlation. 1180: 471:process is very important for 140:, published in Fisher's books 37:For the academic journal, see 13: 1: 7722:Social determinants of health 6565:Geographic information system 5781:Simultaneous equations models 3741:10.1016/j.tplants.2017.08.011 3085:Gujarati, Damodar N. (2006). 2601: 2411:Python (programming language) 2328:restricted maximum likelihood 2128:genome-wide association study 1642:statistical power of the test 1466:(rho) for the population and 998: 995:in the birth rate in Brazil. 940: 863:Genes = {2,3,3,4,5,3,3,3,3,4} 330:. The main propose is called 120:modern evolutionary synthesis 7782:Analysis of variance (ANOVA) 7543:Human factors and ergonomics 5748:Coefficient of determination 5359:Uniformly most powerful test 3052:Jarrell, Stephen B. (1994). 2976:Phil. Trans. R. Soc. Lond. A 2970:Pearson, Karl (1895-01-01). 1861:Gene Set Enrichment Analysis 1848:linear discriminant analysis 1407: 1400: 1397: 1390: 1383: 1378: 1371: 1368: 1363: 978: 540:completely randomized design 104:Arthur Dukinfield Darbishire 7: 7963:Good manufacturing practice 7767:Randomized controlled trial 6317:Proportional hazards models 6261:Spectral density estimation 6243:Vector autoregression (VAR) 5677:Maximum posterior estimator 4909:Randomized controlled trial 4240:"Pharmaceutical Statistics" 3537:"Whither systems medicine?" 2775:10.1177/0115426507022006629 2564: 2471:Scope and training programs 2281:, especially in regards to 1926:, regression, detection of 1815:Use in high-throughput data 1601:Power and statistical error 1520:The hypothesis to be tested 1428:may be plotted as circles. 1416: 463:from all the elements of a 415: 10: 8354: 8033:Theory of planned behavior 7958:Good agricultural practice 7863:Public health surveillance 7755:epidemiological statistics 7399:Public health intervention 6077:Multivariate distributions 4497:Average absolute deviation 3919:"Home - VSN International" 2733:10.1053/j.jvca.2017.04.020 2519: 2116:recombinant inbred strains 1982:statistical classification 1865:JAK-STAT signaling pathway 1825:next-generation sequencers 1694:false discovery rate (FDR) 1647: 1596:Statistical considerations 1503:standard error of the mean 1489: 1331: 1313: 1057: 967:Example of a scatter plot. 671: 72:Biostatistics and genetics 66: 36: 29: 8276: 8211: 8170: 8155:World Toilet Organization 8150:World Health Organization 8057: 8046: 7983: 7908: 7824: 7752: 7717:Public health informatics 7657: 7462: 7424:Right to rest and leisure 7253:Globalization and disease 7188: 7122: 6689: 6591: 6545: 6482: 6435: 6398: 6394: 6381: 6353: 6335: 6302: 6293: 6251: 6198: 6159: 6108: 6099: 6065:Structural equation model 6020: 5977: 5973: 5948: 5907: 5873: 5827: 5794: 5756: 5723: 5719: 5695: 5635: 5544: 5463: 5427: 5418: 5401:Score/Lagrange multiplier 5386: 5339: 5284: 5210: 5201: 5011: 5007: 4994: 4953: 4927: 4879: 4834: 4816:Sample size determination 4781: 4777: 4764: 4668: 4623: 4597: 4579: 4535: 4487: 4407: 4398: 4394: 4381: 4363: 3839:. Chapman & Hall/CRC. 3788:10.1186/gb-2010-11-12-220 3598:10.1007/s10709-004-2705-0 3168:10.1038/nature.2016.19503 3021:Seeing through statistics 3019:Utts, Jessica M. (2005). 2557:Pharmaceutical Statistics 2232:Generalized linear models 2155:marker-assisted selection 1732:Developments and big data 1309: 702:One type of table is the 586:", "incomplete blocks", " 487:across a population. The 350:. On the other hand, the 92:Law of Ancestral Heredity 8201:Schools of public health 7993:Diffusion of innovations 7692:Health impact assessment 7404:Public health laboratory 7300:Management of depression 6560:Environmental statistics 6082:Elliptical distributions 5875:Generalized linear model 5804:Simple linear regression 5574:Hodges–Lehmann estimator 5031:Probability distribution 4940:Stochastic approximation 4502:Coefficient of variation 4258:"Statistics in Medicine" 3100:Watson, Lyndsey (2009). 2313: 2149:, the use of markers in 2108:quantitative trait locus 2057:health services research 1718:Model criteria selection 1713:Model selection criteria 1438:correlation coefficients 1432:Correlation coefficients 265:is proposed to answer a 8264:Social hygiene movement 8191:Doctor of Public Health 8023:Social cognitive theory 7825:Infectious and epidemic 7607:Fecal–oral transmission 6220:Cross-correlation (XCF) 5828:Non-standard predictors 5262:Lehmann–ScheffĂ© theorem 4935:Adaptive clinical trial 4270:10.1002/(ISSN)1097-0258 4262:onlinelibrary.wiley.com 4244:onlinelibrary.wiley.com 4172:10.1002/(ISSN)1521-4036 4164:onlinelibrary.wiley.com 4128:10.1111/(ISSN)1541-0420 4120:onlinelibrary.wiley.com 3721:Trends in Plant Science 3378:Moore, Jason H (2007). 3337:10.1073/pnas.0506580102 2642:"Quantitative Genetics" 2020:converting this section 1951:support vector machines 1932:association rule mining 1867:) using this approach. 1685:(familywise error rate) 1327: 1053: 1008:Example of a histogram. 544:randomized block design 524:experimental statistics 467:. Because of that, the 245:from his department at 205:mathematical biologists 193:The Causes of Evolution 39:Biostatistics (journal) 8259:Germ theory of disease 8038:Transtheoretical model 6749:Biological engineering 6616:Mathematics portal 6437:Engineering statistics 6345:Nelson–Aalen estimator 5922:Analysis of covariance 5809:Ordinary least squares 5733:Pearson product-moment 5137:Statistical functional 5048:Empirical distribution 4881:Controlled experiments 4610:Frequency distribution 4388:Descriptive statistics 4007:Renganathan V (2021). 3646:10.1186/1746-4811-9-29 2997:10.1098/rsta.1895.0010 2576:Epidemiological method 2560:Statistics in Medicine 2256:ecological forecasting 2132:linkage disequilibrium 1666:significance level (α) 1532:alternative hypothesis 1486:Inferential statistics 1456: 1300: 1224: 1158: 1136: 1010: 969: 858:of the same organism. 846: 792: 674:Descriptive statistics 432:is defined as all the 406:alternative hypothesis 383:alternative hypothesis 352:alternative hypothesis 183:inbreeding coefficient 8143:Public Health Service 8028:Social norms approach 8018:PRECEDE–PROCEED model 7464:Preventive healthcare 7357:Pharmaceutical policy 7206:Chief Medical Officer 6834:Developmental biology 6809:Computational biology 6789:Cellular microbiology 6532:Population statistics 6474:System identification 6208:Autocorrelation (ACF) 6136:Exponential smoothing 6050:Discriminant analysis 6045:Canonical correlation 5909:Partition of variance 5771:Regression validation 5615:(Jonckheere–Terpstra) 5514:Likelihood-ratio test 5203:Frequentist inference 5115:Location–scale family 5036:Sampling distribution 5001:Statistical inference 4968:Cross-sectional study 4955:Observational studies 4914:Randomized experiment 4743:Stem-and-leaf display 4545:Central limit theorem 4321:Biomedical Statistics 4294:at Wikimedia Commons 4160:"Biometrical Journal" 3976:10.2134/agronj15.0144 3450:phytozome.jgi.doe.gov 3141:Baker, Monya (2016). 2493:computational biology 2086:Quantitative genetics 1924:unsupervised learning 1689:Bonferroni correction 1624:The type II error or 1542:level of significance 1492:Statistical inference 1451: 1301: 1204: 1159: 1137: 1006: 948: 847: 793: 495:, the trial type, as 483:might catch the most 473:statistical inference 322:Hypothesis definition 297:, and local control. 8219:Sara Josephine Baker 8118:Public Health Agency 8003:Health communication 7868:Disease surveillance 7834:Asymptomatic carrier 7816:Statistical software 7504:Preventive nutrition 7332:Medical anthropology 7221:Environmental health 7054:Reproductive biology 6939:Mathematical biology 6864:Evolutionary biology 6814:Conservation biology 6455:Probabilistic design 6040:Principal components 5883:Exponential families 5835:Nonlinear regression 5814:General linear model 5776:Mixed effects models 5766:Errors and residuals 5743:Confounding variable 5645:Bayesian probability 5623:Van der Waerden test 5613:Ordered alternative 5378:Multiple comparisons 5257:Rao–Blackwellization 5220:Estimating equations 5176:Statistical distance 4894:Factorial experiment 4427:Arithmetic-Geometric 4190:agrobiol.sggw.waw.pl 3835:Terry Speed (2003). 3553:10.1038/emm.2017.290 3522:www.ncbi.nlm.nih.gov 3089:. McGraw-Hill Irwin. 2798:Seminars in Dialysis 2516:Specialized journals 2102:with a variation in 2096:statistical genetics 2065:environmental health 1936:self-organizing maps 1903:Arabidopsis thaliana 1877:biological databases 1760:improve this article 1617:The type I error or 1586:Confidence intervals 1171: 1146: 1072: 809: 718: 566:largely affects the 520:Experimental designs 412:higher or shorter). 316:scientific community 209:evolutionary biology 8229:Carl Rogers Darnall 8224:Samuel Jay Crumbine 7998:Health belief model 7851:Notifiable diseases 7787:Regression analysis 7622:Waterborne diseases 7211:Cultural competence 6839:Ecological genetics 6683:Branches of biology 6527:Official statistics 6450:Methods engineering 6131:Seasonal adjustment 5899:Poisson regressions 5819:Bayesian regression 5758:Regression analysis 5738:Partial correlation 5710:Regression analysis 5309:Prediction interval 5304:Likelihood interval 5294:Confidence interval 5286:Interval estimation 5247:Unbiased estimators 5065:Model specification 4945:Up-and-down designs 4633:Partial correlation 4589:Index of dispersion 4507:Interquartile range 3968:2015AgrJ..107.2263P 3894:. Wiley-Blackwell. 3854:. Wiley-Blackwell. 3733:2017TPS....22..961C 3432:www.arabidopsis.org 3328:2005PNAS..10215545S 3322:(43): 15545–15550. 3267:Statistical Science 3243:10.1038/nj7384-263a 3159:2016Natur.531..151B 2988:1895RSPTA.186..343P 2658:2008Natur.456..719G 2586:Group size measures 2545:Biometrical Journal 2465:Amazon Web Services 2332:variance-covariance 2279:Population dynamics 2092:population genetics 1949:implementation and 1875:The development of 1844:logistic regression 1827:(for genomics) and 1568:: Is made when the 1560:experimental design 1496:It is used to make 1349: 1157:{\displaystyle {n}} 963:Example of Box Plot 879:Relative frequency 876:Absolute frequency 869: 688:measures of central 623:observational study 556:experimental design 515:Experimental design 452:, or all the sperm 308:scientific question 279:experimental design 267:scientific question 166:population dynamics 158:Fisher's exact test 138:Rothamsted Research 127:population genetics 7827:disease prevention 7762:Case–control study 7434:Security of person 7283:Health care reform 7130:History of biology 7064:Structural biology 7049:Relational biology 6874:Generative biology 6869:Freshwater biology 6547:Spatial statistics 6427:Medical statistics 6327:First hitting time 6281:Whittle likelihood 5932:Degrees of freedom 5927:Multivariate ANOVA 5860:Heteroscedasticity 5672:Bayesian estimator 5637:Bayesian inference 5486:Kolmogorov–Smirnov 5371:Randomization test 5341:Testing hypotheses 5314:Tolerance interval 5225:Maximum likelihood 5120:Exponential family 5053:Density estimation 5013:Statistical theory 4973:Natural experiment 4919:Scientific control 4836:Survey methodology 4522:Standard deviation 4314:2012-05-22 at the 3994:cran.r-project.org 3824:. Wiley-Blackwell. 3488:. 11 January 2024. 3486:www.ddbj.nig.ac.jp 3428:"TAIR - Home Page" 2949:. Academic Press. 2334:matrix structures. 2022:, if appropriate. 1638:significance level 1510:Hypothesis testing 1457: 1345: 1296: 1154: 1132: 1011: 970: 957:The birth rate in 955:Bar chart example. 951:Line graph example 868: 842: 788: 354:is the denial of H 239:Thomas Hunt Morgan 228:On Growth and Form 8320: 8319: 8272: 8271: 8182:Higher education 8013:Positive deviance 8008:Health psychology 7984:Health behavioral 7911:safety management 7885:Social distancing 7659:Population health 7639:Smoking cessation 7587:Pharmacovigilance 7558:Injury prevention 7526:Infection control 7444:Social psychology 7394:Prisoners' rights 7337:Medical sociology 7305:Public health law 7201:Biological hazard 7148: 7147: 7069:Synthetic biology 6949:Molecular biology 6804:Cognitive biology 6649: 6648: 6587: 6586: 6583: 6582: 6522:National accounts 6492:Actuarial science 6484:Social statistics 6377: 6376: 6373: 6372: 6369: 6368: 6304:Survival function 6289: 6288: 6151:Granger causality 5992:Contingency table 5967:Survival analysis 5944: 5943: 5940: 5939: 5796:Linear regression 5691: 5690: 5687: 5686: 5662:Credible interval 5631: 5630: 5414: 5413: 5230:Method of moments 5099:Parametric family 5060:Statistical model 4990: 4989: 4986: 4985: 4904:Random assignment 4826:Statistical power 4760: 4759: 4756: 4755: 4605:Contingency table 4575: 4574: 4442:Generalized/power 4290:Media related to 4208:www.degruyter.com 3901:978-3-527-32750-8 3861:978-3-527-32585-6 3397:10.1002/jcp.21218 3289:10.1214/07-STS236 3236:(7384): 263–265. 3201:"Null hypothesis" 2956:978-0-12-262270-0 2340:crossover designs 2283:fisheries science 2273:Clinical research 2262:sequence analysis 2112:molecular markers 2041: 2040: 1976:In recent times, 1835:Multicollinearity 1829:mass spectrometry 1792: 1791: 1784: 1414: 1413: 1334:Mode (statistics) 1294: 1197: 1183: 938: 937: 840: 668:Descriptive tools 650:quantitative data 548:factorial designs 493:clinical research 312:literature review 301:Research question 257:Research planning 243:Friden calculator 162:Fisher's equation 116:Wilhelm Johannsen 112:Charles Davenport 51:) is a branch of 16:(Redirected from 8345: 8308: 8307: 8296: 8295: 8284: 8283: 8178:Health education 8055: 8054: 7909:Food hygiene and 7890:Tropical disease 7702:Infant mortality 7677:Community health 7553:Controlled Drugs 7489:Health promotion 7419:Right to housing 7263:Health economics 7175: 7168: 7161: 7152: 7151: 6794:Chemical biology 6676: 6669: 6662: 6653: 6652: 6637: 6636: 6625: 6624: 6614: 6613: 6599: 6598: 6502:Crime statistics 6396: 6395: 6383: 6382: 6300: 6299: 6266:Fourier analysis 6253:Frequency domain 6233: 6180: 6146:Structural break 6106: 6105: 6055:Cluster analysis 6002:Log-linear model 5975: 5974: 5950: 5949: 5891: 5865:Homoscedasticity 5721: 5720: 5697: 5696: 5616: 5608: 5600: 5599:(Kruskal–Wallis) 5584: 5569: 5524:Cross validation 5509: 5491:Anderson–Darling 5438: 5425: 5424: 5396:Likelihood-ratio 5388:Parametric tests 5366:Permutation test 5349:1- & 2-tails 5240:Minimum distance 5212:Point estimation 5208: 5207: 5159:Optimal decision 5110: 5009: 5008: 4996: 4995: 4978:Quasi-experiment 4928:Adaptive designs 4779: 4778: 4766: 4765: 4643:Rank correlation 4405: 4404: 4396: 4395: 4383: 4382: 4350: 4343: 4336: 4327: 4326: 4289: 4274: 4273: 4254: 4248: 4247: 4236: 4230: 4229: 4218: 4212: 4211: 4200: 4194: 4193: 4182: 4176: 4175: 4156: 4150: 4149: 4138: 4132: 4131: 4112: 4106: 4103:https://ebph.it/ 4100: 4094: 4093: 4086: 4080: 4079: 4072: 4066: 4065: 4054: 4048: 4047: 4045: 4044: 4029: 4023: 4022: 4004: 3998: 3997: 3986: 3980: 3979: 3956:Agronomy Journal 3951: 3945: 3944: 3933: 3927: 3926: 3915: 3906: 3905: 3887: 3881: 3880: 3872: 3866: 3865: 3847: 3841: 3840: 3832: 3826: 3825: 3817: 3811: 3810: 3800: 3790: 3766: 3760: 3759: 3757: 3718: 3708: 3702: 3701: 3699: 3684:The Plant Genome 3675: 3669: 3668: 3658: 3648: 3624: 3618: 3617: 3581: 3575: 3574: 3564: 3532: 3526: 3525: 3514: 3508: 3507: 3496: 3490: 3489: 3478: 3472: 3471: 3460: 3454: 3453: 3442: 3436: 3435: 3424: 3418: 3417: 3399: 3380:"Bioinformatics" 3375: 3360: 3359: 3349: 3339: 3307: 3301: 3300: 3282: 3262: 3256: 3255: 3245: 3221: 3215: 3214: 3212: 3211: 3205:www.statlect.com 3197: 3191: 3187: 3181: 3180: 3170: 3138: 3132: 3131: 3121: 3097: 3091: 3090: 3082: 3076: 3075: 3054:Basic statistics 3049: 3043: 3042: 3016: 3010: 3009: 2999: 2967: 2961: 2960: 2942: 2929: 2928: 2917: 2908: 2907: 2905: 2904: 2898:www.sangakoo.com 2892:Maths, Sangaku. 2889: 2883: 2882: 2856: 2836: 2830: 2829: 2793: 2787: 2786: 2758: 2745: 2744: 2727:(5): 1878–1882. 2716: 2705: 2704: 2702: 2695: 2686: 2680: 2679: 2669: 2637: 2631: 2630: 2628: 2627: 2612: 2591:Health indicator 2508:), business and 2430:numerical python 2401:machine learning 2385:for programming. 2303:Pharmacokinetics 2298:Pharmacodynamics 2159:cross-validation 2080:Systems medicine 2036: 2033: 2027: 2018:You can help by 2000: 1999: 1992: 1916:machine learning 1805:Machine learning 1787: 1780: 1776: 1773: 1767: 1744: 1736: 1682:falses positives 1676:Multiple testing 1350: 1344: 1305: 1303: 1302: 1297: 1295: 1290: 1289: 1288: 1270: 1269: 1257: 1256: 1246: 1241: 1237: 1236: 1235: 1234: 1223: 1218: 1198: 1190: 1185: 1184: 1176: 1163: 1161: 1160: 1155: 1153: 1141: 1139: 1138: 1133: 1131: 1130: 1129: 1111: 1110: 1098: 1097: 1085: 1084: 870: 867: 864: 851: 849: 848: 843: 841: 836: 835: 826: 821: 820: 797: 795: 794: 789: 787: 786: 762: 761: 749: 748: 736: 735: 698:Frequency tables 646:qualitative data 625:designs such as 607:clinical studies 596:error estimation 310:, an exhaustive 261:Any research in 189:J. B. S. Haldane 172:Sewall G. Wright 21: 8353: 8352: 8348: 8347: 8346: 8344: 8343: 8342: 8323: 8322: 8321: 8316: 8268: 8239:Margaret Sanger 8207: 8166: 8050: 8048: 8042: 7985: 7979: 7951:Safety scandals 7910: 7904: 7826: 7820: 7754: 7748: 7744:Social medicine 7737:Race and health 7672:Child mortality 7653: 7612:Open defecation 7494:Human nutrition 7484:Family planning 7472:Behavior change 7458: 7414:Right to health 7327:Maternal health 7317:Health politics 7268:Health literacy 7184: 7179: 7149: 7144: 7118: 7079:Systems biology 7044:Quantum biology 6685: 6680: 6650: 6645: 6608: 6579: 6541: 6478: 6464:quality control 6431: 6413:Clinical trials 6390: 6365: 6349: 6337:Hazard function 6331: 6285: 6247: 6231: 6194: 6190:Breusch–Godfrey 6178: 6155: 6095: 6070:Factor analysis 6016: 5997:Graphical model 5969: 5936: 5903: 5889: 5869: 5823: 5790: 5752: 5715: 5714: 5683: 5627: 5614: 5606: 5598: 5582: 5567: 5546:Rank statistics 5540: 5519:Model selection 5507: 5465:Goodness of fit 5459: 5436: 5410: 5382: 5335: 5280: 5269:Median unbiased 5197: 5108: 5041:Order statistic 5003: 4982: 4949: 4923: 4875: 4830: 4773: 4771:Data collection 4752: 4664: 4619: 4593: 4571: 4531: 4483: 4400:Continuous data 4390: 4377: 4359: 4354: 4316:Wayback Machine 4283: 4278: 4277: 4256: 4255: 4251: 4238: 4237: 4233: 4220: 4219: 4215: 4202: 4201: 4197: 4184: 4183: 4179: 4158: 4157: 4153: 4140: 4139: 4135: 4114: 4113: 4109: 4101: 4097: 4092:. 15 June 2018. 4088: 4087: 4083: 4074: 4073: 4069: 4056: 4055: 4051: 4042: 4040: 4030: 4026: 4019: 4005: 4001: 3988: 3987: 3983: 3952: 3948: 3935: 3934: 3930: 3917: 3916: 3909: 3902: 3888: 3884: 3873: 3869: 3862: 3848: 3844: 3833: 3829: 3818: 3814: 3767: 3763: 3755: 3727:(11): 961–975. 3716: 3709: 3705: 3676: 3672: 3625: 3621: 3582: 3578: 3533: 3529: 3516: 3515: 3511: 3498: 3497: 3493: 3480: 3479: 3475: 3462: 3461: 3457: 3444: 3443: 3439: 3426: 3425: 3421: 3376: 3363: 3308: 3304: 3263: 3259: 3222: 3218: 3209: 3207: 3199: 3198: 3194: 3188: 3184: 3139: 3135: 3098: 3094: 3083: 3079: 3064: 3050: 3046: 3031: 3017: 3013: 2968: 2964: 2957: 2943: 2932: 2919: 2918: 2911: 2902: 2900: 2890: 2886: 2854:10.1.1.472.7825 2837: 2833: 2794: 2790: 2759: 2748: 2717: 2708: 2700: 2693: 2687: 2683: 2667:10.1038/456719a 2638: 2634: 2625: 2623: 2613: 2609: 2604: 2567: 2524: 2518: 2506:quality control 2501:clinical trials 2473: 2316: 2267:Systems biology 2248: 2200: 2198:Expression data 2178:Animal breeding 2088: 2073:clinical trials 2046: 2037: 2031: 2028: 2017: 2001: 1997: 1990: 1963: 1947:neural networks 1873: 1839:gene expression 1817: 1788: 1777: 1771: 1768: 1757: 1745: 1734: 1715: 1706: 1698:null hypotheses 1678: 1672:) is rejected. 1671: 1663: 1658:null hypothesis 1650: 1630:null hypothesis 1603: 1598: 1579: 1570:null hypothesis 1529: 1524:null hypothesis 1494: 1488: 1446: 1434: 1419: 1347: 1336: 1330: 1318: 1312: 1284: 1280: 1265: 1261: 1252: 1248: 1247: 1245: 1230: 1226: 1225: 1219: 1208: 1203: 1199: 1189: 1175: 1174: 1172: 1169: 1168: 1149: 1147: 1144: 1143: 1125: 1121: 1106: 1102: 1093: 1089: 1080: 1076: 1075: 1073: 1070: 1069: 1066:arithmetic mean 1062: 1056: 1048:scatter diagram 1027: 1001: 981: 943: 862: 831: 827: 825: 816: 812: 810: 807: 806: 782: 778: 757: 753: 744: 740: 731: 727: 719: 716: 715: 700: 676: 670: 665: 657:metric measures 639: 637:Data collection 517: 448:, as the whole 418: 396: 392: 388: 380: 376: 372: 364: 357: 349: 345: 342:. In general, H 337: 332:null hypothesis 324: 303: 283:data collection 259: 224:D'Arcy Thompson 197:primordial soup 96:William Bateson 74: 69: 47:(also known as 42: 35: 28: 23: 22: 15: 12: 11: 5: 8351: 8341: 8340: 8338:Bioinformatics 8335: 8318: 8317: 8315: 8314: 8302: 8290: 8277: 8274: 8273: 8270: 8269: 8267: 8266: 8261: 8256: 8251: 8246: 8241: 8236: 8231: 8226: 8221: 8215: 8213: 8209: 8208: 8206: 8205: 8204: 8203: 8198: 8193: 8188: 8180: 8174: 8172: 8168: 8167: 8165: 8164: 8157: 8152: 8147: 8146: 8145: 8140: 8135: 8130: 8122: 8121: 8120: 8115: 8107: 8106: 8105: 8097: 8096: 8095: 8090: 8082: 8081: 8080: 8072: 8071: 8070: 8061: 8059: 8052: 8047:Organizations, 8044: 8043: 8041: 8040: 8035: 8030: 8025: 8020: 8015: 8010: 8005: 8000: 7995: 7989: 7987: 7981: 7980: 7978: 7977: 7976: 7975: 7970: 7960: 7955: 7954: 7953: 7948: 7943: 7938: 7933: 7928: 7923: 7914: 7912: 7906: 7905: 7903: 7902: 7897: 7892: 7887: 7882: 7877: 7872: 7871: 7870: 7860: 7859: 7858: 7848: 7847: 7846: 7836: 7830: 7828: 7822: 7821: 7819: 7818: 7813: 7812: 7811: 7803: 7794: 7789: 7784: 7774: 7769: 7764: 7758: 7756: 7753:Biological and 7750: 7749: 7747: 7746: 7741: 7740: 7739: 7734: 7729: 7719: 7714: 7712:Multimorbidity 7709: 7704: 7699: 7694: 7689: 7684: 7679: 7674: 7669: 7663: 7661: 7655: 7654: 7652: 7651: 7649:Vector control 7646: 7641: 7636: 7634:School hygiene 7631: 7630: 7629: 7624: 7619: 7617:Sanitary sewer 7614: 7609: 7604: 7594: 7589: 7584: 7583: 7582: 7575:Patient safety 7572: 7571: 7570: 7565: 7560: 7555: 7550: 7545: 7535: 7534: 7533: 7528: 7523: 7518: 7508: 7507: 7506: 7501: 7491: 7486: 7481: 7480: 7479: 7468: 7466: 7460: 7459: 7457: 7456: 7451: 7446: 7441: 7436: 7431: 7426: 7421: 7416: 7411: 7406: 7401: 7396: 7391: 7390: 7389: 7384: 7379: 7374: 7369: 7359: 7354: 7349: 7339: 7334: 7329: 7324: 7319: 7314: 7313: 7312: 7307: 7297: 7292: 7287: 7286: 7285: 7280: 7270: 7265: 7260: 7258:Harm reduction 7255: 7250: 7245: 7240: 7239: 7238: 7233: 7223: 7218: 7213: 7208: 7203: 7198: 7192: 7190: 7186: 7185: 7178: 7177: 7170: 7163: 7155: 7146: 7145: 7143: 7142: 7137: 7132: 7126: 7124: 7120: 7119: 7117: 7116: 7111: 7106: 7101: 7096: 7091: 7086: 7081: 7076: 7071: 7066: 7061: 7056: 7051: 7046: 7041: 7036: 7031: 7026: 7021: 7016: 7011: 7006: 7001: 6996: 6991: 6986: 6981: 6976: 6971: 6966: 6961: 6956: 6951: 6946: 6941: 6936: 6934:Marine biology 6931: 6926: 6921: 6916: 6911: 6906: 6901: 6896: 6891: 6886: 6881: 6876: 6871: 6866: 6861: 6856: 6851: 6846: 6841: 6836: 6831: 6826: 6821: 6816: 6811: 6806: 6801: 6796: 6791: 6786: 6781: 6776: 6771: 6766: 6761: 6756: 6751: 6746: 6744:Bioinformatics 6741: 6736: 6731: 6726: 6721: 6716: 6711: 6706: 6701: 6696: 6690: 6687: 6686: 6679: 6678: 6671: 6664: 6656: 6647: 6646: 6644: 6643: 6631: 6619: 6605: 6592: 6589: 6588: 6585: 6584: 6581: 6580: 6578: 6577: 6572: 6567: 6562: 6557: 6551: 6549: 6543: 6542: 6540: 6539: 6534: 6529: 6524: 6519: 6514: 6509: 6504: 6499: 6494: 6488: 6486: 6480: 6479: 6477: 6476: 6471: 6466: 6457: 6452: 6447: 6441: 6439: 6433: 6432: 6430: 6429: 6424: 6419: 6410: 6408:Bioinformatics 6404: 6402: 6392: 6391: 6379: 6378: 6375: 6374: 6371: 6370: 6367: 6366: 6364: 6363: 6357: 6355: 6351: 6350: 6348: 6347: 6341: 6339: 6333: 6332: 6330: 6329: 6324: 6319: 6314: 6308: 6306: 6297: 6291: 6290: 6287: 6286: 6284: 6283: 6278: 6273: 6268: 6263: 6257: 6255: 6249: 6248: 6246: 6245: 6240: 6235: 6227: 6222: 6217: 6216: 6215: 6213:partial (PACF) 6204: 6202: 6196: 6195: 6193: 6192: 6187: 6182: 6174: 6169: 6163: 6161: 6160:Specific tests 6157: 6156: 6154: 6153: 6148: 6143: 6138: 6133: 6128: 6123: 6118: 6112: 6110: 6103: 6097: 6096: 6094: 6093: 6092: 6091: 6090: 6089: 6074: 6073: 6072: 6062: 6060:Classification 6057: 6052: 6047: 6042: 6037: 6032: 6026: 6024: 6018: 6017: 6015: 6014: 6009: 6007:McNemar's test 6004: 5999: 5994: 5989: 5983: 5981: 5971: 5970: 5946: 5945: 5942: 5941: 5938: 5937: 5935: 5934: 5929: 5924: 5919: 5913: 5911: 5905: 5904: 5902: 5901: 5885: 5879: 5877: 5871: 5870: 5868: 5867: 5862: 5857: 5852: 5847: 5845:Semiparametric 5842: 5837: 5831: 5829: 5825: 5824: 5822: 5821: 5816: 5811: 5806: 5800: 5798: 5792: 5791: 5789: 5788: 5783: 5778: 5773: 5768: 5762: 5760: 5754: 5753: 5751: 5750: 5745: 5740: 5735: 5729: 5727: 5717: 5716: 5713: 5712: 5707: 5701: 5693: 5692: 5689: 5688: 5685: 5684: 5682: 5681: 5680: 5679: 5669: 5664: 5659: 5658: 5657: 5652: 5641: 5639: 5633: 5632: 5629: 5628: 5626: 5625: 5620: 5619: 5618: 5610: 5602: 5586: 5583:(Mann–Whitney) 5578: 5577: 5576: 5563: 5562: 5561: 5550: 5548: 5542: 5541: 5539: 5538: 5537: 5536: 5531: 5526: 5516: 5511: 5508:(Shapiro–Wilk) 5503: 5498: 5493: 5488: 5483: 5475: 5469: 5467: 5461: 5460: 5458: 5457: 5449: 5440: 5428: 5422: 5420:Specific tests 5416: 5415: 5412: 5411: 5409: 5408: 5403: 5398: 5392: 5390: 5384: 5383: 5381: 5380: 5375: 5374: 5373: 5363: 5362: 5361: 5351: 5345: 5343: 5337: 5336: 5334: 5333: 5332: 5331: 5326: 5316: 5311: 5306: 5301: 5296: 5290: 5288: 5282: 5281: 5279: 5278: 5273: 5272: 5271: 5266: 5265: 5264: 5259: 5244: 5243: 5242: 5237: 5232: 5227: 5216: 5214: 5205: 5199: 5198: 5196: 5195: 5190: 5185: 5184: 5183: 5173: 5168: 5167: 5166: 5156: 5155: 5154: 5149: 5144: 5134: 5129: 5124: 5123: 5122: 5117: 5112: 5096: 5095: 5094: 5089: 5084: 5074: 5073: 5072: 5067: 5057: 5056: 5055: 5045: 5044: 5043: 5033: 5028: 5023: 5017: 5015: 5005: 5004: 4992: 4991: 4988: 4987: 4984: 4983: 4981: 4980: 4975: 4970: 4965: 4959: 4957: 4951: 4950: 4948: 4947: 4942: 4937: 4931: 4929: 4925: 4924: 4922: 4921: 4916: 4911: 4906: 4901: 4896: 4891: 4885: 4883: 4877: 4876: 4874: 4873: 4871:Standard error 4868: 4863: 4858: 4857: 4856: 4851: 4840: 4838: 4832: 4831: 4829: 4828: 4823: 4818: 4813: 4808: 4803: 4801:Optimal design 4798: 4793: 4787: 4785: 4775: 4774: 4762: 4761: 4758: 4757: 4754: 4753: 4751: 4750: 4745: 4740: 4735: 4730: 4725: 4720: 4715: 4710: 4705: 4700: 4695: 4690: 4685: 4680: 4674: 4672: 4666: 4665: 4663: 4662: 4657: 4656: 4655: 4650: 4640: 4635: 4629: 4627: 4621: 4620: 4618: 4617: 4612: 4607: 4601: 4599: 4598:Summary tables 4595: 4594: 4592: 4591: 4585: 4583: 4577: 4576: 4573: 4572: 4570: 4569: 4568: 4567: 4562: 4557: 4547: 4541: 4539: 4533: 4532: 4530: 4529: 4524: 4519: 4514: 4509: 4504: 4499: 4493: 4491: 4485: 4484: 4482: 4481: 4476: 4471: 4470: 4469: 4464: 4459: 4454: 4449: 4444: 4439: 4434: 4432:Contraharmonic 4429: 4424: 4413: 4411: 4402: 4392: 4391: 4379: 4378: 4376: 4375: 4370: 4364: 4361: 4360: 4353: 4352: 4345: 4338: 4330: 4324: 4323: 4318: 4306: 4301: 4282: 4281:External links 4279: 4276: 4275: 4249: 4231: 4213: 4195: 4177: 4151: 4133: 4107: 4095: 4081: 4067: 4049: 4024: 4017: 3999: 3981: 3946: 3941:www.vsni.co.uk 3928: 3923:www.vsni.co.uk 3907: 3900: 3882: 3867: 3860: 3842: 3827: 3812: 3775:Genome Biology 3761: 3703: 3670: 3619: 3592:(1–2): 25–37. 3576: 3527: 3509: 3491: 3473: 3455: 3437: 3419: 3361: 3302: 3257: 3216: 3192: 3182: 3133: 3112:(2): 196–197. 3092: 3077: 3063:978-0697215956 3062: 3044: 3030:978-0534394028 3029: 3011: 2962: 2955: 2930: 2909: 2884: 2847:(3): 246–255. 2831: 2804:(5): 347–351. 2788: 2746: 2706: 2681: 2632: 2606: 2605: 2603: 2600: 2599: 2598: 2593: 2588: 2583: 2578: 2573: 2571:Bioinformatics 2566: 2563: 2562: 2561: 2558: 2555: 2552: 2549: 2546: 2543: 2540: 2537: 2534: 2531: 2528: 2517: 2514: 2489:bioinformatics 2472: 2469: 2468: 2467: 2462: 2457: 2452: 2447: 2446:linear algebra 2441: 2436: 2431: 2425: 2420: 2414: 2408: 2390: 2386: 2372: 2349: 2343: 2335: 2315: 2312: 2311: 2310: 2305: 2300: 2295: 2286: 2276: 2270: 2264: 2258: 2247: 2244: 2199: 2196: 2195: 2194: 2192:human genetics 2181: 2170:Plant breeding 2147:plant breeding 2136:SNP genotyping 2087: 2084: 2045: 2042: 2039: 2038: 2004: 2002: 1995: 1989: 1986: 1978:random forests 1962: 1959: 1872: 1869: 1816: 1813: 1801:Bioinformatics 1799:technologies, 1790: 1789: 1748: 1746: 1739: 1733: 1730: 1714: 1711: 1705: 1702: 1677: 1674: 1669: 1661: 1649: 1646: 1634: 1633: 1626:false negative 1622: 1619:false positive 1602: 1599: 1597: 1594: 1589: 1588: 1582: 1581: 1577: 1563: 1553: 1550:test statistic 1546:critical value 1535: 1527: 1513: 1512: 1490:Main article: 1487: 1484: 1445: 1442: 1433: 1430: 1418: 1415: 1412: 1411: 1406: 1399: 1395: 1394: 1389: 1388:, 3, 4, 4, 11 1382: 1376: 1375: 1370: 1367: 1361: 1360: 1357: 1354: 1332:Main article: 1329: 1326: 1314:Main article: 1311: 1308: 1307: 1306: 1293: 1287: 1283: 1279: 1276: 1273: 1268: 1264: 1260: 1255: 1251: 1244: 1240: 1233: 1229: 1222: 1217: 1214: 1211: 1207: 1202: 1196: 1193: 1188: 1182: 1179: 1152: 1128: 1124: 1120: 1117: 1114: 1109: 1105: 1101: 1096: 1092: 1088: 1083: 1079: 1058:Main article: 1055: 1052: 1026: 1023: 1000: 997: 980: 977: 942: 939: 936: 935: 932: 929: 925: 924: 921: 918: 914: 913: 910: 907: 903: 902: 899: 896: 892: 891: 888: 885: 881: 880: 877: 874: 866: 865: 839: 834: 830: 824: 819: 815: 785: 781: 777: 774: 771: 768: 765: 760: 756: 752: 747: 743: 739: 734: 730: 726: 723: 699: 696: 672:Main article: 669: 666: 664: 661: 638: 635: 580:microorganisms 554:, the correct 516: 513: 417: 414: 394: 390: 386: 378: 374: 370: 362: 355: 347: 343: 335: 323: 320: 302: 299: 258: 255: 217:quantitatively 201: 200: 186: 169: 100:Raphael Weldon 88:Francis Galton 73: 70: 68: 65: 26: 9: 6: 4: 3: 2: 8350: 8339: 8336: 8334: 8333:Biostatistics 8331: 8330: 8328: 8313: 8312: 8303: 8301: 8300: 8291: 8289: 8288: 8279: 8278: 8275: 8265: 8262: 8260: 8257: 8255: 8252: 8250: 8247: 8245: 8242: 8240: 8237: 8235: 8234:Joseph Lister 8232: 8230: 8227: 8225: 8222: 8220: 8217: 8216: 8214: 8210: 8202: 8199: 8197: 8194: 8192: 8189: 8187: 8184: 8183: 8181: 8179: 8176: 8175: 8173: 8169: 8162: 8158: 8156: 8153: 8151: 8148: 8144: 8141: 8139: 8136: 8134: 8131: 8129: 8126: 8125: 8123: 8119: 8116: 8114: 8113:Health Canada 8111: 8110: 8108: 8104: 8101: 8100: 8098: 8094: 8091: 8089: 8086: 8085: 8083: 8079: 8076: 8075: 8073: 8069: 8066: 8065: 8063: 8062: 8060: 8058:Organizations 8056: 8053: 8045: 8039: 8036: 8034: 8031: 8029: 8026: 8024: 8021: 8019: 8016: 8014: 8011: 8009: 8006: 8004: 8001: 7999: 7996: 7994: 7991: 7990: 7988: 7982: 7974: 7971: 7969: 7966: 7965: 7964: 7961: 7959: 7956: 7952: 7949: 7947: 7944: 7942: 7939: 7937: 7934: 7932: 7929: 7927: 7924: 7922: 7919: 7918: 7916: 7915: 7913: 7907: 7901: 7898: 7896: 7895:Vaccine trial 7893: 7891: 7888: 7886: 7883: 7881: 7878: 7876: 7873: 7869: 7866: 7865: 7864: 7861: 7857: 7854: 7853: 7852: 7849: 7845: 7842: 7841: 7840: 7837: 7835: 7832: 7831: 7829: 7823: 7817: 7814: 7810: 7808: 7804: 7802: 7800: 7795: 7793: 7790: 7788: 7785: 7783: 7780: 7779: 7778: 7775: 7773: 7772:Relative risk 7770: 7768: 7765: 7763: 7760: 7759: 7757: 7751: 7745: 7742: 7738: 7735: 7733: 7732:Health equity 7730: 7728: 7725: 7724: 7723: 7720: 7718: 7715: 7713: 7710: 7708: 7705: 7703: 7700: 7698: 7697:Health system 7695: 7693: 7690: 7688: 7687:Global health 7685: 7683: 7680: 7678: 7675: 7673: 7670: 7668: 7667:Biostatistics 7665: 7664: 7662: 7660: 7656: 7650: 7647: 7645: 7642: 7640: 7637: 7635: 7632: 7628: 7625: 7623: 7620: 7618: 7615: 7613: 7610: 7608: 7605: 7603: 7600: 7599: 7598: 7595: 7593: 7590: 7588: 7585: 7581: 7578: 7577: 7576: 7573: 7569: 7566: 7564: 7561: 7559: 7556: 7554: 7551: 7549: 7546: 7544: 7541: 7540: 7539: 7536: 7532: 7529: 7527: 7524: 7522: 7519: 7517: 7514: 7513: 7512: 7509: 7505: 7502: 7500: 7497: 7496: 7495: 7492: 7490: 7487: 7485: 7482: 7478: 7475: 7474: 7473: 7470: 7469: 7467: 7465: 7461: 7455: 7452: 7450: 7447: 7445: 7442: 7440: 7437: 7435: 7432: 7430: 7427: 7425: 7422: 7420: 7417: 7415: 7412: 7410: 7409:Right to food 7407: 7405: 7402: 7400: 7397: 7395: 7392: 7388: 7385: 7383: 7380: 7378: 7375: 7373: 7370: 7368: 7365: 7364: 7363: 7360: 7358: 7355: 7353: 7350: 7347: 7343: 7342:Mental health 7340: 7338: 7335: 7333: 7330: 7328: 7325: 7323: 7320: 7318: 7315: 7311: 7308: 7306: 7303: 7302: 7301: 7298: 7296: 7293: 7291: 7290:Housing First 7288: 7284: 7281: 7279: 7278:Health system 7276: 7275: 7274: 7273:Health policy 7271: 7269: 7266: 7264: 7261: 7259: 7256: 7254: 7251: 7249: 7246: 7244: 7241: 7237: 7234: 7232: 7229: 7228: 7227: 7224: 7222: 7219: 7217: 7214: 7212: 7209: 7207: 7204: 7202: 7199: 7197: 7194: 7193: 7191: 7187: 7183: 7182:Public health 7176: 7171: 7169: 7164: 7162: 7157: 7156: 7153: 7141: 7138: 7136: 7133: 7131: 7128: 7127: 7125: 7121: 7115: 7112: 7110: 7107: 7105: 7102: 7100: 7097: 7095: 7092: 7090: 7087: 7085: 7082: 7080: 7077: 7075: 7072: 7070: 7067: 7065: 7062: 7060: 7057: 7055: 7052: 7050: 7047: 7045: 7042: 7040: 7037: 7035: 7032: 7030: 7027: 7025: 7022: 7020: 7017: 7015: 7014:Phylogenetics 7012: 7010: 7007: 7005: 7002: 7000: 6997: 6995: 6992: 6990: 6987: 6985: 6982: 6980: 6977: 6975: 6972: 6970: 6967: 6965: 6962: 6960: 6957: 6955: 6952: 6950: 6947: 6945: 6942: 6940: 6937: 6935: 6932: 6930: 6927: 6925: 6922: 6920: 6917: 6915: 6912: 6910: 6909:Human biology 6907: 6905: 6902: 6900: 6897: 6895: 6892: 6890: 6887: 6885: 6882: 6880: 6877: 6875: 6872: 6870: 6867: 6865: 6862: 6860: 6857: 6855: 6852: 6850: 6847: 6845: 6842: 6840: 6837: 6835: 6832: 6830: 6827: 6825: 6822: 6820: 6817: 6815: 6812: 6810: 6807: 6805: 6802: 6800: 6799:Chronobiology 6797: 6795: 6792: 6790: 6787: 6785: 6782: 6780: 6777: 6775: 6774:Biotechnology 6772: 6770: 6769:Biostatistics 6767: 6765: 6762: 6760: 6757: 6755: 6752: 6750: 6747: 6745: 6742: 6740: 6737: 6735: 6732: 6730: 6727: 6725: 6722: 6720: 6717: 6715: 6712: 6710: 6707: 6705: 6702: 6700: 6697: 6695: 6692: 6691: 6688: 6684: 6677: 6672: 6670: 6665: 6663: 6658: 6657: 6654: 6642: 6641: 6632: 6630: 6629: 6620: 6618: 6617: 6612: 6606: 6604: 6603: 6594: 6593: 6590: 6576: 6573: 6571: 6570:Geostatistics 6568: 6566: 6563: 6561: 6558: 6556: 6553: 6552: 6550: 6548: 6544: 6538: 6537:Psychometrics 6535: 6533: 6530: 6528: 6525: 6523: 6520: 6518: 6515: 6513: 6510: 6508: 6505: 6503: 6500: 6498: 6495: 6493: 6490: 6489: 6487: 6485: 6481: 6475: 6472: 6470: 6467: 6465: 6461: 6458: 6456: 6453: 6451: 6448: 6446: 6443: 6442: 6440: 6438: 6434: 6428: 6425: 6423: 6420: 6418: 6414: 6411: 6409: 6406: 6405: 6403: 6401: 6400:Biostatistics 6397: 6393: 6389: 6384: 6380: 6362: 6361:Log-rank test 6359: 6358: 6356: 6352: 6346: 6343: 6342: 6340: 6338: 6334: 6328: 6325: 6323: 6320: 6318: 6315: 6313: 6310: 6309: 6307: 6305: 6301: 6298: 6296: 6292: 6282: 6279: 6277: 6274: 6272: 6269: 6267: 6264: 6262: 6259: 6258: 6256: 6254: 6250: 6244: 6241: 6239: 6236: 6234: 6232:(Box–Jenkins) 6228: 6226: 6223: 6221: 6218: 6214: 6211: 6210: 6209: 6206: 6205: 6203: 6201: 6197: 6191: 6188: 6186: 6185:Durbin–Watson 6183: 6181: 6175: 6173: 6170: 6168: 6167:Dickey–Fuller 6165: 6164: 6162: 6158: 6152: 6149: 6147: 6144: 6142: 6141:Cointegration 6139: 6137: 6134: 6132: 6129: 6127: 6124: 6122: 6119: 6117: 6116:Decomposition 6114: 6113: 6111: 6107: 6104: 6102: 6098: 6088: 6085: 6084: 6083: 6080: 6079: 6078: 6075: 6071: 6068: 6067: 6066: 6063: 6061: 6058: 6056: 6053: 6051: 6048: 6046: 6043: 6041: 6038: 6036: 6033: 6031: 6028: 6027: 6025: 6023: 6019: 6013: 6010: 6008: 6005: 6003: 6000: 5998: 5995: 5993: 5990: 5988: 5987:Cohen's kappa 5985: 5984: 5982: 5980: 5976: 5972: 5968: 5964: 5960: 5956: 5951: 5947: 5933: 5930: 5928: 5925: 5923: 5920: 5918: 5915: 5914: 5912: 5910: 5906: 5900: 5896: 5892: 5886: 5884: 5881: 5880: 5878: 5876: 5872: 5866: 5863: 5861: 5858: 5856: 5853: 5851: 5848: 5846: 5843: 5841: 5840:Nonparametric 5838: 5836: 5833: 5832: 5830: 5826: 5820: 5817: 5815: 5812: 5810: 5807: 5805: 5802: 5801: 5799: 5797: 5793: 5787: 5784: 5782: 5779: 5777: 5774: 5772: 5769: 5767: 5764: 5763: 5761: 5759: 5755: 5749: 5746: 5744: 5741: 5739: 5736: 5734: 5731: 5730: 5728: 5726: 5722: 5718: 5711: 5708: 5706: 5703: 5702: 5698: 5694: 5678: 5675: 5674: 5673: 5670: 5668: 5665: 5663: 5660: 5656: 5653: 5651: 5648: 5647: 5646: 5643: 5642: 5640: 5638: 5634: 5624: 5621: 5617: 5611: 5609: 5603: 5601: 5595: 5594: 5593: 5590: 5589:Nonparametric 5587: 5585: 5579: 5575: 5572: 5571: 5570: 5564: 5560: 5559:Sample median 5557: 5556: 5555: 5552: 5551: 5549: 5547: 5543: 5535: 5532: 5530: 5527: 5525: 5522: 5521: 5520: 5517: 5515: 5512: 5510: 5504: 5502: 5499: 5497: 5494: 5492: 5489: 5487: 5484: 5482: 5480: 5476: 5474: 5471: 5470: 5468: 5466: 5462: 5456: 5454: 5450: 5448: 5446: 5441: 5439: 5434: 5430: 5429: 5426: 5423: 5421: 5417: 5407: 5404: 5402: 5399: 5397: 5394: 5393: 5391: 5389: 5385: 5379: 5376: 5372: 5369: 5368: 5367: 5364: 5360: 5357: 5356: 5355: 5352: 5350: 5347: 5346: 5344: 5342: 5338: 5330: 5327: 5325: 5322: 5321: 5320: 5317: 5315: 5312: 5310: 5307: 5305: 5302: 5300: 5297: 5295: 5292: 5291: 5289: 5287: 5283: 5277: 5274: 5270: 5267: 5263: 5260: 5258: 5255: 5254: 5253: 5250: 5249: 5248: 5245: 5241: 5238: 5236: 5233: 5231: 5228: 5226: 5223: 5222: 5221: 5218: 5217: 5215: 5213: 5209: 5206: 5204: 5200: 5194: 5191: 5189: 5186: 5182: 5179: 5178: 5177: 5174: 5172: 5169: 5165: 5164:loss function 5162: 5161: 5160: 5157: 5153: 5150: 5148: 5145: 5143: 5140: 5139: 5138: 5135: 5133: 5130: 5128: 5125: 5121: 5118: 5116: 5113: 5111: 5105: 5102: 5101: 5100: 5097: 5093: 5090: 5088: 5085: 5083: 5080: 5079: 5078: 5075: 5071: 5068: 5066: 5063: 5062: 5061: 5058: 5054: 5051: 5050: 5049: 5046: 5042: 5039: 5038: 5037: 5034: 5032: 5029: 5027: 5024: 5022: 5019: 5018: 5016: 5014: 5010: 5006: 5002: 4997: 4993: 4979: 4976: 4974: 4971: 4969: 4966: 4964: 4961: 4960: 4958: 4956: 4952: 4946: 4943: 4941: 4938: 4936: 4933: 4932: 4930: 4926: 4920: 4917: 4915: 4912: 4910: 4907: 4905: 4902: 4900: 4897: 4895: 4892: 4890: 4887: 4886: 4884: 4882: 4878: 4872: 4869: 4867: 4866:Questionnaire 4864: 4862: 4859: 4855: 4852: 4850: 4847: 4846: 4845: 4842: 4841: 4839: 4837: 4833: 4827: 4824: 4822: 4819: 4817: 4814: 4812: 4809: 4807: 4804: 4802: 4799: 4797: 4794: 4792: 4789: 4788: 4786: 4784: 4780: 4776: 4772: 4767: 4763: 4749: 4746: 4744: 4741: 4739: 4736: 4734: 4731: 4729: 4726: 4724: 4721: 4719: 4716: 4714: 4711: 4709: 4706: 4704: 4701: 4699: 4696: 4694: 4693:Control chart 4691: 4689: 4686: 4684: 4681: 4679: 4676: 4675: 4673: 4671: 4667: 4661: 4658: 4654: 4651: 4649: 4646: 4645: 4644: 4641: 4639: 4636: 4634: 4631: 4630: 4628: 4626: 4622: 4616: 4613: 4611: 4608: 4606: 4603: 4602: 4600: 4596: 4590: 4587: 4586: 4584: 4582: 4578: 4566: 4563: 4561: 4558: 4556: 4553: 4552: 4551: 4548: 4546: 4543: 4542: 4540: 4538: 4534: 4528: 4525: 4523: 4520: 4518: 4515: 4513: 4510: 4508: 4505: 4503: 4500: 4498: 4495: 4494: 4492: 4490: 4486: 4480: 4477: 4475: 4472: 4468: 4465: 4463: 4460: 4458: 4455: 4453: 4450: 4448: 4445: 4443: 4440: 4438: 4435: 4433: 4430: 4428: 4425: 4423: 4420: 4419: 4418: 4415: 4414: 4412: 4410: 4406: 4403: 4401: 4397: 4393: 4389: 4384: 4380: 4374: 4371: 4369: 4366: 4365: 4362: 4358: 4351: 4346: 4344: 4339: 4337: 4332: 4331: 4328: 4322: 4319: 4317: 4313: 4310: 4307: 4305: 4302: 4300: 4297: 4296: 4295: 4293: 4292:Biostatistics 4288: 4271: 4267: 4263: 4259: 4253: 4245: 4241: 4235: 4227: 4226:SAGE Journals 4223: 4217: 4210:. 1 May 2002. 4209: 4205: 4199: 4191: 4187: 4181: 4173: 4169: 4165: 4161: 4155: 4147: 4143: 4137: 4129: 4125: 4121: 4117: 4111: 4104: 4099: 4091: 4085: 4077: 4071: 4063: 4059: 4053: 4039: 4035: 4028: 4020: 4018:9789354936586 4014: 4010: 4003: 3995: 3991: 3985: 3977: 3973: 3969: 3965: 3961: 3957: 3950: 3942: 3938: 3932: 3924: 3920: 3914: 3912: 3903: 3897: 3893: 3886: 3878: 3871: 3863: 3857: 3853: 3846: 3838: 3831: 3823: 3816: 3808: 3804: 3799: 3794: 3789: 3784: 3780: 3776: 3772: 3765: 3754: 3750: 3746: 3742: 3738: 3734: 3730: 3726: 3722: 3715: 3707: 3698: 3693: 3689: 3685: 3681: 3674: 3666: 3662: 3657: 3652: 3647: 3642: 3638: 3634: 3633:Plant Methods 3630: 3623: 3615: 3611: 3607: 3603: 3599: 3595: 3591: 3587: 3580: 3572: 3568: 3563: 3558: 3554: 3550: 3546: 3542: 3538: 3531: 3523: 3519: 3513: 3505: 3504:www.ebi.ac.uk 3501: 3495: 3487: 3483: 3477: 3469: 3468:www.insdc.org 3465: 3459: 3451: 3447: 3441: 3433: 3429: 3423: 3415: 3411: 3407: 3403: 3398: 3393: 3389: 3385: 3381: 3374: 3372: 3370: 3368: 3366: 3357: 3353: 3348: 3343: 3338: 3333: 3329: 3325: 3321: 3317: 3313: 3306: 3298: 3294: 3290: 3286: 3281: 3276: 3272: 3268: 3261: 3253: 3249: 3244: 3239: 3235: 3231: 3227: 3220: 3206: 3202: 3196: 3186: 3178: 3174: 3169: 3164: 3160: 3156: 3153:(7593): 151. 3152: 3148: 3144: 3137: 3129: 3125: 3120: 3115: 3111: 3107: 3103: 3096: 3088: 3081: 3073: 3069: 3065: 3059: 3055: 3048: 3040: 3036: 3032: 3026: 3022: 3015: 3007: 3003: 2998: 2993: 2989: 2985: 2981: 2977: 2973: 2966: 2958: 2952: 2948: 2941: 2939: 2937: 2935: 2926: 2922: 2916: 2914: 2899: 2895: 2888: 2880: 2876: 2872: 2868: 2864: 2860: 2855: 2850: 2846: 2842: 2835: 2827: 2823: 2819: 2815: 2811: 2807: 2803: 2799: 2792: 2784: 2780: 2776: 2772: 2769:(6): 629–35. 2768: 2764: 2757: 2755: 2753: 2751: 2742: 2738: 2734: 2730: 2726: 2722: 2715: 2713: 2711: 2699: 2692: 2685: 2677: 2673: 2668: 2663: 2659: 2655: 2652:(7223): 719. 2651: 2647: 2643: 2636: 2622: 2621:www.eoas.info 2618: 2611: 2607: 2597: 2594: 2592: 2589: 2587: 2584: 2582: 2579: 2577: 2574: 2572: 2569: 2568: 2559: 2556: 2553: 2550: 2547: 2544: 2541: 2538: 2535: 2532: 2529: 2527:Biostatistics 2526: 2525: 2523: 2513: 2511: 2507: 2502: 2498: 2497:public health 2494: 2490: 2486: 2480: 2478: 2466: 2463: 2461: 2458: 2456: 2455:Apache Hadoop 2453: 2451: 2448: 2445: 2442: 2440: 2437: 2435: 2432: 2429: 2426: 2424: 2421: 2418: 2415: 2412: 2409: 2406: 2402: 2399:software for 2398: 2394: 2391: 2387: 2384: 2380: 2379:SAS Institute 2376: 2373: 2370: 2366: 2361: 2357: 2353: 2350: 2347: 2344: 2341: 2336: 2333: 2329: 2325: 2322: 2321: 2320: 2309: 2306: 2304: 2301: 2299: 2296: 2294: 2290: 2289:Phylogenetics 2287: 2284: 2280: 2277: 2274: 2271: 2268: 2265: 2263: 2259: 2257: 2253: 2250: 2249: 2246:Other studies 2243: 2241: 2237: 2233: 2229: 2225: 2221: 2217: 2213: 2209: 2206:data, as for 2205: 2193: 2189: 2186: 2182: 2179: 2175: 2171: 2167: 2166: 2165: 2162: 2160: 2156: 2152: 2148: 2144: 2139: 2137: 2133: 2129: 2123: 2121: 2117: 2113: 2109: 2105: 2101: 2097: 2093: 2090:The study of 2083: 2081: 2076: 2074: 2070: 2066: 2062: 2058: 2054: 2050: 2049:Public health 2044:Public health 2035: 2026:is available. 2025: 2021: 2015: 2014: 2010: 2005:This section 2003: 1994: 1993: 1985: 1983: 1979: 1974: 1972: 1968: 1967:bootstrapping 1958: 1954: 1952: 1948: 1944: 1942: 1937: 1933: 1929: 1925: 1921: 1917: 1912: 1910: 1905: 1904: 1899: 1898:Gene Ontology 1895: 1891: 1887: 1883: 1878: 1868: 1866: 1862: 1857: 1854: 1853:least squares 1849: 1845: 1840: 1836: 1832: 1830: 1826: 1822: 1812: 1810: 1806: 1802: 1798: 1786: 1783: 1775: 1772:December 2016 1765: 1761: 1755: 1754: 1749:This section 1747: 1743: 1738: 1737: 1729: 1727: 1723: 1719: 1710: 1701: 1699: 1695: 1690: 1686: 1683: 1673: 1667: 1659: 1655: 1645: 1643: 1639: 1631: 1627: 1623: 1620: 1616: 1615: 1614: 1612: 1611:Type II error 1608: 1593: 1587: 1584: 1583: 1575: 1571: 1567: 1564: 1561: 1557: 1554: 1551: 1547: 1543: 1539: 1536: 1533: 1525: 1521: 1518: 1517: 1516: 1511: 1508: 1507: 1506: 1504: 1499: 1493: 1483: 1481: 1477: 1473: 1469: 1465: 1461: 1455: 1450: 1441: 1439: 1429: 1427: 1423: 1410: 1404: 1403:3, 3, 3, 3, 3 1396: 1393: 1387: 1381: 1377: 1374: 1366: 1362: 1358: 1355: 1352: 1351: 1343: 1341: 1335: 1325: 1323: 1317: 1291: 1285: 1281: 1277: 1274: 1271: 1266: 1262: 1258: 1253: 1249: 1242: 1238: 1231: 1227: 1220: 1215: 1212: 1209: 1205: 1200: 1194: 1191: 1186: 1177: 1167: 1166: 1165: 1150: 1126: 1122: 1118: 1115: 1112: 1107: 1103: 1099: 1094: 1090: 1086: 1081: 1077: 1067: 1061: 1051: 1049: 1045: 1041: 1040:scatter chart 1037: 1036:scatter graph 1032: 1022: 1020: 1016: 1009: 1005: 996: 994: 989: 986: 976: 974: 968: 964: 960: 956: 952: 947: 933: 930: 927: 926: 922: 919: 916: 915: 911: 908: 905: 904: 900: 897: 894: 893: 889: 886: 883: 882: 878: 875: 873:Genes number 872: 871: 861: 860: 859: 857: 852: 837: 832: 828: 822: 817: 813: 804: 802: 798: 783: 779: 775: 772: 769: 766: 763: 758: 754: 750: 745: 741: 737: 732: 728: 724: 721: 713: 711: 707: 705: 695: 693: 690:tendency and 689: 685: 681: 675: 660: 658: 653: 651: 647: 642: 634: 632: 628: 624: 620: 616: 612: 608: 603: 601: 597: 593: 592:control plots 589: 585: 581: 577: 573: 569: 565: 561: 557: 553: 549: 545: 541: 537: 533: 529: 525: 521: 512: 510: 506: 502: 498: 494: 490: 486: 482: 478: 474: 470: 466: 462: 457: 455: 451: 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Index

Biometry
Biometrics
Biostatistics (journal)
statistics
biology
experiments
Genetics
Gregor Mendel
Francis Galton
Law of Ancestral Heredity
William Bateson
Raphael Weldon
Arthur Dukinfield Darbishire
Karl Pearson
Charles Davenport
Wilhelm Johannsen
modern evolutionary synthesis
population genetics
Ronald Fisher
Rothamsted Research
Statistical Methods for Research Workers
The Genetical Theory of Natural Selection
ANOVA
p-value
Fisher's exact test
Fisher's equation
population dynamics
Sewall G. Wright
F-statistics
inbreeding coefficient

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