306:
283:
205:
180:
571:
564:
557:
312:
211:
1230:(PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region
29:
1250:
was constructed for BMP1. This plot shows that BMP1 most prefers Phi and Psi angles (Phi, Psi) of around (-60°,-45°) and (-60°, 140°). These preferred angles are an estimate of the most clustered data of the
Ramachandran plot. The preferred region is much greater in range. 97% of the residues were
1229:
The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase
1242:
with a resolution of 1.27 Å. Crystallization experiments were done by vapor diffusion at a pH of 7.5. This is important because it is close to the pH of the human body, where BMP1 resides in vivo. This BMP1 fragment is 202 residues in length. Its secondary structure is made up of 30% helices, or
55:
1414:
Mac
Sweeney A, Gil-Parrado S, Vinzenz D, Bernardi A, Hein A, Bodendorf U, Erbel P, Logel C, Gerhartz B (December 2008). "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases".
1773:"Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis"
319:
218:
1578:
Yoshiura K, Tamura T, Hong HS, et al. (1993). "Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome".
1545:"Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues"
1607:
Takahara K, Lee S, Wood S, Greenspan DS (1996). "Structural organization and genetic localization of the human bone morphogenetic protein 1/mammalian tolloid gene".
1923:"Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases"
1734:
Janitz M, Heiser V, Böttcher U, et al. (1998). "Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1".
854:
141:
1841:
Scott IC, Blitz IL, Pappano WN, et al. (2001). "Homologues of
Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling".
1243:
10 helices, 61 residues in length, and 15% beta sheets, or 11 strands, 32 residues in length. It contains ligands of an acetyl group and a Zinc ion.
835:
1683:"The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1"
1176:
2319:
1328:
1310:
52:
2712:
2266:
2247:
1093:
1086:
2600:
2339:
1349:
1450:
1636:
Kessler E, Takahara K, Biniaminov L, et al. (1996). "Bone morphogenetic protein-1: the type I procollagen C-proteinase".
1187:
superfamily. It was initially discovered to work like other BMPs by inducing bone and cartilage development. It however, is a
2661:
2081:"Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity"
1293:
2702:
1514:
Wozney JM, Rosen V, Celeste AJ, et al. (1989). "Novel regulators of bone formation: molecular clones and activities".
2272:
2253:
2707:
2348:
2312:
1272:
1993:"Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein"
1888:"Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity"
305:
1958:"Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen"
282:
1297:
1276:
1184:
2305:
899:
1363:
Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS (February 1991).
880:
204:
179:
121:
2236:
2560:
2555:
1180:
318:
217:
311:
210:
108:
2676:
2493:
2336:
2240:
1808:"Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain"
1069:
1014:
129:
2116:"Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network"
2028:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1183:(BMPs). It induces bone and cartilage development. Unlike other BMPs, it does not belong to the
1065:
1044:
1040:
1010:
989:
979:
975:
971:
967:
963:
2297:
1481:"Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3"
1365:"Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3"
2722:
2651:
1251:
in preferred regions and 100% of the residues were in the allowed region, with no outliers.
2717:
2332:
2289:
2039:
1850:
1694:
1645:
193:
149:
8:
2727:
2278:
2259:
2043:
1854:
1698:
1649:
1874:
1759:
1669:
1164:
153:
2212:
2185:
2062:
2027:
1561:
1544:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
698:
693:
688:
683:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
2217:
2172:
2137:
2102:
2067:
2014:
1979:
1944:
1909:
1866:
1829:
1794:
1751:
1722:
1717:
1682:
1661:
1624:
1595:
1566:
1531:
1502:
1497:
1480:
1432:
1404:
1386:
1381:
1364:
1247:
1239:
101:
45:
1763:
1673:
1457:
2207:
2197:
2162:
2127:
2092:
2057:
2047:
2004:
1969:
1934:
1899:
1878:
1858:
1819:
1784:
1743:
1712:
1702:
1653:
1616:
1587:
1556:
1523:
1492:
1424:
1376:
398:
329:
273:
228:
133:
2356:
1657:
1204:
1188:
373:
157:
1333:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1315:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1200:
474:
1428:
2696:
1196:
599:
570:
563:
556:
2151:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1707:
1527:
534:
412:
2221:
2202:
2176:
2141:
2132:
2115:
2106:
2097:
2080:
2071:
2052:
2018:
2009:
1992:
1983:
1974:
1957:
1948:
1939:
1922:
1913:
1904:
1887:
1870:
1833:
1824:
1807:
1798:
1789:
1772:
1620:
1436:
391:
170:
1755:
1747:
1726:
1665:
1628:
1599:
1570:
1535:
1506:
1390:
1133:
1128:
2671:
2656:
2501:
944:
925:
2646:
2518:
1192:
290:
187:
137:
1591:
1408:
78:
74:
1862:
1413:
1219:
799:
357:
344:
256:
243:
145:
2681:
2483:
2478:
2473:
2328:
2167:
2150:
1212:
1117:
2468:
2463:
2458:
2453:
2448:
2443:
2438:
1208:
1153:
911:
866:
784:
780:
2327:
125:
2605:
2433:
2428:
2423:
2418:
2413:
2408:
2403:
2398:
2376:
2371:
2366:
2285:
1223:
1101:
821:
579:
2630:
2625:
2620:
2615:
2610:
2595:
2590:
2585:
2580:
2575:
2570:
2565:
2550:
2545:
2393:
2388:
2383:
2361:
2078:
1990:
2540:
2535:
2528:
2523:
2511:
2506:
2026:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1160:
112:, bone morphogenetic protein 1, OI13, PCOLC, PCP, PCP2, TLD
1885:
1362:
1635:
2025:
1606:
381:
28:
1956:
Rattenholl A, Pappano WN, Koch M, et al. (2002).
1542:
2288:
online database for peptidases and their inhibitors:
1955:
1921:
Unsöld C, Pappano WN, Imamura Y, et al. (2002).
1479:
Tabas JA, Zasloff M, Wasmuth JJ, et al. (1991).
1163:. There are seven isoforms of the protein created by
546:
1920:
1771:
Scott IC, Blitz IL, Pappano WN, et al. (1999).
1733:
2183:
1806:Amano S, Scott IC, Takahara K, et al. (2000).
1478:
1451:"MolProbity Ramachandran analysis of 3EDG, model 1"
1238:A partial structure of BMP1 was determined through
2149:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
2148:
1805:
1577:
1513:
1289:
1287:
1285:
1268:
1266:
1264:
1222:and is localized in the basal epithelial layer of
1840:
1770:
1681:Li SW, Sieron AL, Fertala A, et al. (1996).
328:
227:
2694:
2079:Hartigan N, Garrigue-Antar L, Kadler KE (2003).
1991:Garrigue-Antar L, Hartigan N, Kadler KE (2003).
1350:"Entrez Gene: BMP1 bone morphogenetic protein 1"
1680:
1282:
1261:
2113:
1886:Garrigue-Antar L, Barker C, Kadler KE (2001).
1443:
1294:GRCm38: Ensembl release 89: ENSMUSG00000022098
2313:
2186:"An unappreciated role for RNA surveillance"
750:positive regulation of cartilage development
1543:Takahara K, Lyons GE, Greenspan DS (1995).
1397:
1273:GRCh38: Ensembl release 89: ENSG00000168487
2320:
2306:
1356:
760:high-density lipoprotein particle assembly
2239:at the U.S. National Library of Medicine
2211:
2201:
2184:Hillman RT, Green RE, Brenner SE (2005).
2166:
2131:
2096:
2061:
2051:
2008:
1973:
1938:
1903:
1823:
1788:
1716:
1706:
1560:
1496:
1380:
765:regulation of signaling receptor activity
1344:
1342:
16:Mammalian protein found in Homo sapiens
2695:
2662:Pregnancy-associated plasma protein A
2301:
1339:
333:
294:
289:
232:
191:
186:
13:
1471:
1156:which in humans is encoded by the
740:multicellular organism development
658:serine-type endopeptidase activity
14:
2739:
2230:
2713:Developmental genes and proteins
730:extracellular matrix disassembly
569:
562:
555:
317:
310:
304:
281:
216:
209:
203:
178:
27:
2114:Leighton M, Kadler KE (2003).
1456:. www.rcsb.org. Archived from
1321:
1303:
580:More reference expression data
535:More reference expression data
1:
1562:10.1016/S0021-9258(18)31672-7
1254:
638:metalloendopeptidase activity
302:
201:
2667:Bone morphogenetic protein 1
2237:bone+morphogenetic+protein+1
2032:Proc. Natl. Acad. Sci. U.S.A
1687:Proc. Natl. Acad. Sci. U.S.A
1658:10.1126/science.271.5247.360
1498:10.1016/0888-7543(91)90254-C
1382:10.1016/0888-7543(91)90254-C
1233:
1218:It has been shown to cleave
1146:Bone morphogenetic protein 1
7:
2703:Genes on human chromosome 8
1181:bone morphogenetic proteins
1170:
715:skeletal system development
423:stromal cell of endometrium
10:
2744:
2708:Bone morphogenetic protein
2277:gene details page in the
2258:gene details page in the
2639:
2494:Matrix metalloproteinases
2492:
2347:
1429:10.1016/j.jmb.2008.09.029
1329:"Mouse PubMed Reference:"
1311:"Human PubMed Reference:"
1132:
1127:
1123:
1116:
1100:
1081:
1062:
1058:
1037:
1033:
1026:
1007:
1003:
986:
962:
955:
942:
938:
923:
919:
910:
897:
893:
878:
874:
865:
852:
848:
833:
829:
820:
805:
798:
794:
778:
668:identical protein binding
653:metallopeptidase activity
598:
594:
577:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
2677:Insulin-degrading enzyme
2241:Medical Subject Headings
1094:Chr 14: 70.47 – 70.52 Mb
1708:10.1073/pnas.93.10.5127
1528:10.1126/science.3201241
1087:Chr 8: 22.17 – 22.21 Mb
513:internal carotid artery
509:external carotid artery
2203:10.1186/gb-2004-5-2-r8
2133:10.1074/jbc.M213021200
2098:10.1074/jbc.M211448200
2053:10.1073/pnas.242603899
2010:10.1074/jbc.M207342200
1975:10.1074/jbc.M203247200
1940:10.1074/jbc.M110003200
1905:10.1074/jbc.M010814200
1825:10.1074/jbc.M002345200
1790:10.1006/dbio.1999.9383
1621:10.1006/geno.1995.1209
755:cartilage condensation
643:growth factor activity
335:14 D2|14 36.32 cM
2652:Procollagen peptidase
2333:metalloendopeptidases
1748:10.1007/s001090050202
1580:Cytogenet. Cell Genet
745:cartilage development
493:stroma of bone marrow
451:right coronary artery
296:Chromosome 14 (mouse)
2271:genome location and
2252:genome location and
1175:BMP1 belongs to the
720:cell differentiation
689:extracellular region
435:left coronary artery
431:right adrenal cortex
194:Chromosome 8 (human)
67:List of PDB id codes
40:Available structures
2279:UCSC Genome Browser
2260:UCSC Genome Browser
2044:2002PNAS...9916899M
1855:2001Natur.410..475S
1699:1996PNAS...93.5127L
1650:1996Sci...271..360K
770:signal transduction
699:extracellular space
613:calcium ion binding
447:left adrenal cortex
439:canal of the cervix
1165:alternate splicing
900:ENSMUSG00000022098
708:Biological process
677:Cellular component
648:hydrolase activity
628:peptidase activity
606:Molecular function
2690:
2689:
2038:(26): 16899–903.
1592:10.1159/000133577
1522:(4885): 1528–34.
1248:Ramachandran plot
1240:X-Ray diffraction
1191:that cleaves the
1143:
1142:
1139:
1138:
1112:
1111:
1077:
1076:
1052:
1051:
1022:
1021:
997:
996:
951:
950:
932:
931:
906:
905:
887:
886:
861:
860:
842:
841:
790:
789:
663:cytokine activity
623:metal ion binding
590:
589:
586:
585:
541:
540:
528:
527:
489:cerebellar cortex
466:
465:
427:left uterine tube
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
2735:
2357:Alpha secretases
2322:
2315:
2308:
2299:
2298:
2225:
2215:
2205:
2180:
2170:
2145:
2135:
2126:(20): 18478–84.
2110:
2100:
2075:
2065:
2055:
2022:
2012:
2003:(45): 43327–34.
1987:
1977:
1952:
1942:
1917:
1907:
1898:(28): 26237–42.
1882:
1863:10.1038/35068572
1837:
1827:
1818:(30): 22728–35.
1802:
1792:
1767:
1730:
1720:
1710:
1677:
1632:
1603:
1574:
1564:
1539:
1510:
1500:
1465:
1464:
1462:
1455:
1447:
1441:
1440:
1411:
1401:
1395:
1394:
1384:
1360:
1354:
1353:
1346:
1337:
1336:
1325:
1319:
1318:
1307:
1301:
1291:
1280:
1270:
1148:, also known as
1125:
1124:
1096:
1089:
1072:
1056:
1055:
1047:
1031:
1030:
1027:RefSeq (protein)
1017:
1001:
1000:
992:
960:
959:
936:
935:
917:
916:
891:
890:
872:
871:
846:
845:
827:
826:
796:
795:
618:zinc ion binding
596:
595:
582:
573:
566:
559:
552:
551:
537:
477:
475:Top expressed in
470:
469:
415:
413:Top expressed in
408:
407:
387:
386:
370:
369:
360:
347:
336:
321:
314:
308:
297:
285:
269:
268:
259:
246:
235:
220:
213:
207:
196:
182:
166:
165:
160:
158:BMP1 - orthologs
111:
104:
81:
64:
63:
58:
37:
36:
31:
19:
18:
2743:
2742:
2738:
2737:
2736:
2734:
2733:
2732:
2693:
2692:
2691:
2686:
2635:
2488:
2343:
2326:
2295:
2233:
2228:
2091:(20): 18045–9.
1968:(29): 26372–8.
1933:(7): 5596–602.
1849:(6827): 475–8.
1693:(10): 5127–30.
1644:(5247): 360–2.
1555:(51): 32572–8.
1474:
1472:Further reading
1469:
1468:
1460:
1453:
1449:
1448:
1444:
1403:
1402:
1398:
1361:
1357:
1348:
1347:
1340:
1327:
1326:
1322:
1309:
1308:
1304:
1292:
1283:
1271:
1262:
1257:
1236:
1189:metalloprotease
1173:
1134:View/Edit Mouse
1129:View/Edit Human
1092:
1085:
1082:Location (UCSC)
1068:
1064:
1043:
1039:
1013:
1009:
988:
982:
978:
974:
970:
966:
881:ENSG00000168487
774:
703:
684:Golgi apparatus
672:
633:protein binding
578:
568:
567:
561:
560:
533:
524:
519:
515:
511:
507:
503:
499:
495:
491:
487:
473:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
355:
342:
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
120:
107:
100:
73:
51:
17:
12:
11:
5:
2741:
2731:
2730:
2725:
2720:
2715:
2710:
2705:
2688:
2687:
2685:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2643:
2641:
2637:
2636:
2634:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2532:
2531:
2526:
2516:
2515:
2514:
2509:
2498:
2496:
2490:
2489:
2487:
2486:
2481:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2380:
2379:
2374:
2369:
2364:
2353:
2351:
2345:
2344:
2325:
2324:
2317:
2310:
2302:
2293:
2292:
2282:
2263:
2244:
2232:
2231:External links
2229:
2227:
2226:
2181:
2168:10.1038/ng1285
2146:
2111:
2076:
2023:
1988:
1953:
1918:
1883:
1838:
1803:
1783:(2): 283–300.
1768:
1731:
1678:
1633:
1604:
1586:(3–4): 208–9.
1575:
1540:
1511:
1475:
1473:
1470:
1467:
1466:
1463:on 2012-10-12.
1442:
1396:
1355:
1338:
1320:
1302:
1281:
1259:
1258:
1256:
1253:
1235:
1232:
1177:peptidase M12A
1172:
1169:
1141:
1140:
1137:
1136:
1131:
1121:
1120:
1114:
1113:
1110:
1109:
1107:
1105:
1098:
1097:
1090:
1083:
1079:
1078:
1075:
1074:
1060:
1059:
1053:
1050:
1049:
1035:
1034:
1028:
1024:
1023:
1020:
1019:
1005:
1004:
998:
995:
994:
984:
983:
957:
953:
952:
949:
948:
940:
939:
933:
930:
929:
921:
920:
914:
908:
907:
904:
903:
895:
894:
888:
885:
884:
876:
875:
869:
863:
862:
859:
858:
850:
849:
843:
840:
839:
831:
830:
824:
818:
817:
812:
807:
803:
802:
792:
791:
788:
787:
776:
775:
773:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
711:
709:
705:
704:
702:
701:
696:
691:
686:
680:
678:
674:
673:
671:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
609:
607:
603:
602:
592:
591:
588:
587:
584:
583:
575:
574:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
459:gastric mucosa
456:
455:body of uterus
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
9:
6:
4:
3:
2:
2740:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2700:
2698:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2644:
2642:
2638:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2530:
2527:
2525:
2522:
2521:
2520:
2517:
2513:
2510:
2508:
2505:
2504:
2503:
2500:
2499:
2497:
2495:
2491:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2359:
2358:
2355:
2354:
2352:
2350:
2349:ADAM proteins
2346:
2341:
2338:
2334:
2330:
2323:
2318:
2316:
2311:
2309:
2304:
2303:
2300:
2296:
2291:
2287:
2283:
2280:
2276:
2275:
2270:
2269:
2264:
2261:
2257:
2256:
2251:
2250:
2245:
2242:
2238:
2235:
2234:
2223:
2219:
2214:
2209:
2204:
2199:
2195:
2191:
2187:
2182:
2178:
2174:
2169:
2164:
2160:
2156:
2152:
2147:
2143:
2139:
2134:
2129:
2125:
2121:
2120:J. Biol. Chem
2117:
2112:
2108:
2104:
2099:
2094:
2090:
2086:
2085:J. Biol. Chem
2082:
2077:
2073:
2069:
2064:
2059:
2054:
2049:
2045:
2041:
2037:
2033:
2029:
2024:
2020:
2016:
2011:
2006:
2002:
1998:
1997:J. Biol. Chem
1994:
1989:
1985:
1981:
1976:
1971:
1967:
1963:
1962:J. Biol. Chem
1959:
1954:
1950:
1946:
1941:
1936:
1932:
1928:
1927:J. Biol. Chem
1924:
1919:
1915:
1911:
1906:
1901:
1897:
1893:
1892:J. Biol. Chem
1889:
1884:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1839:
1835:
1831:
1826:
1821:
1817:
1813:
1812:J. Biol. Chem
1809:
1804:
1800:
1796:
1791:
1786:
1782:
1778:
1774:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1737:
1732:
1728:
1724:
1719:
1714:
1709:
1704:
1700:
1696:
1692:
1688:
1684:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1634:
1630:
1626:
1622:
1618:
1614:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1576:
1572:
1568:
1563:
1558:
1554:
1550:
1549:J. Biol. Chem
1546:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1512:
1508:
1504:
1499:
1494:
1490:
1486:
1482:
1477:
1476:
1459:
1452:
1446:
1438:
1434:
1430:
1426:
1423:(1): 228–39.
1422:
1418:
1410:
1406:
1400:
1392:
1388:
1383:
1378:
1374:
1370:
1366:
1359:
1351:
1345:
1343:
1334:
1330:
1324:
1316:
1312:
1306:
1299:
1295:
1290:
1288:
1286:
1278:
1274:
1269:
1267:
1265:
1260:
1252:
1249:
1244:
1241:
1231:
1227:
1225:
1221:
1216:
1214:
1210:
1206:
1202:
1198:
1197:procollagen I
1194:
1190:
1186:
1182:
1178:
1168:
1166:
1162:
1159:
1155:
1151:
1147:
1135:
1130:
1126:
1122:
1119:
1115:
1108:
1106:
1103:
1099:
1095:
1091:
1088:
1084:
1080:
1073:
1071:
1067:
1061:
1057:
1054:
1048:
1046:
1042:
1036:
1032:
1029:
1025:
1018:
1016:
1012:
1006:
1002:
999:
993:
991:
985:
981:
977:
973:
969:
965:
961:
958:
956:RefSeq (mRNA)
954:
947:
946:
941:
937:
934:
928:
927:
922:
918:
915:
913:
909:
902:
901:
896:
892:
889:
883:
882:
877:
873:
870:
868:
864:
857:
856:
851:
847:
844:
838:
837:
832:
828:
825:
823:
819:
816:
813:
811:
808:
804:
801:
797:
793:
786:
782:
777:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
712:
710:
707:
706:
700:
697:
695:
692:
690:
687:
685:
682:
681:
679:
676:
675:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
610:
608:
605:
604:
601:
600:Gene ontology
597:
593:
581:
576:
572:
565:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
505:body of femur
504:
500:
496:
492:
488:
484:
483:
480:
476:
471:
468:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
331:
327:
320:
313:
307:
300:
292:
288:
284:
279:
275:
270:
266:
258:
253:
249:
245:
240:
230:
226:
219:
212:
206:
199:
195:
189:
185:
181:
176:
172:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
115:
110:
103:
98:
93:
82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2723:EGFCA domain
2666:
2502:Collagenases
2294:
2273:
2267:
2254:
2248:
2193:
2189:
2158:
2154:
2123:
2119:
2088:
2084:
2035:
2031:
2000:
1996:
1965:
1961:
1930:
1926:
1895:
1891:
1846:
1842:
1815:
1811:
1780:
1776:
1742:(2): 141–6.
1739:
1735:
1690:
1686:
1641:
1637:
1612:
1608:
1583:
1579:
1552:
1548:
1519:
1515:
1491:(2): 283–9.
1488:
1484:
1458:the original
1445:
1420:
1417:J. Mol. Biol
1416:
1399:
1375:(2): 283–9.
1372:
1368:
1358:
1332:
1323:
1314:
1305:
1245:
1237:
1228:
1217:
1207:. It has an
1174:
1157:
1149:
1145:
1144:
1070:NP_001346950
1063:
1038:
1015:NM_001360021
1008:
987:
943:
924:
898:
879:
853:
834:
814:
809:
725:ossification
397:
390:
117:External IDs
72:
2718:ZnMc domain
2672:Lysostaphin
2657:Thermolysin
2519:Gelatinases
2190:Genome Biol
2161:(1): 40–5.
1736:J. Mol. Med
1615:(1): 9–15.
735:proteolysis
356:70,520,234
343:70,474,558
255:22,212,326
242:22,165,140
95:Identifiers
2728:CUB domain
2697:Categories
2647:Neprilysin
2155:Nat. Genet
1300:, May 2017
1279:, May 2017
1255:References
1193:C-terminus
1179:family of
443:ectocervix
401:(ortholog)
138:HomoloGene
2329:Proteases
2196:(2): R8.
1777:Dev. Biol
1412:;
1234:Structure
1220:laminin 5
1066:NP_033885
1045:NP_006120
1041:NP_001190
1011:NM_009755
990:NM_006132
980:NM_006131
976:NM_006130
972:NM_006129
968:NM_006128
964:NM_001199
800:Orthologs
146:GeneCards
2682:ZMPSTE24
2484:ADAMTS13
2479:ADAMTS12
2474:ADAMTS10
2222:14759258
2177:14702039
2142:12637569
2107:12637537
2072:12477932
2019:12218058
1984:11986329
1949:11741999
1914:11283002
1871:11260715
1834:10806203
1799:10479448
1764:26374071
1674:26378870
1609:Genomics
1485:Genomics
1437:18824173
1369:Genomics
1296:–
1275:–
1215:domain.
1213:protease
1171:Function
1118:Wikidata
779:Sources:
517:calvaria
485:gastrula
2469:ADAMTS9
2464:ADAMTS8
2459:ADAMTS5
2454:ADAMTS4
2449:ADAMTS3
2444:ADAMTS2
2439:ADAMTS1
2290:M12.005
2040:Bibcode
1879:4392365
1851:Bibcode
1756:9500680
1727:8643539
1695:Bibcode
1666:8553073
1646:Bibcode
1638:Science
1629:8530106
1600:8404039
1571:7798260
1536:3201241
1516:Science
1507:2004778
1391:2004778
1298:Ensembl
1277:Ensembl
1209:astacin
1154:protein
1152:, is a
912:UniProt
867:Ensembl
806:Species
785:QuickGO
694:vesicle
501:decidua
376:pattern
102:Aliases
2606:MMP23B
2601:MMP23A
2434:ADAM33
2429:ADAM28
2424:ADAM23
2419:ADAM22
2414:ADAM18
2409:ADAM15
2404:ADAM12
2399:ADAM11
2377:ADAM19
2372:ADAM17
2367:ADAM10
2340:3.4.24
2286:MEROPS
2265:Human
2246:Human
2243:(MeSH)
2220:
2213:395752
2210:
2175:
2140:
2105:
2070:
2063:139241
2060:
2017:
1982:
1947:
1912:
1877:
1869:
1843:Nature
1832:
1797:
1762:
1754:
1725:
1715:
1672:
1664:
1627:
1598:
1569:
1534:
1505:
1435:
1389:
1226:skin.
1224:bovine
1211:-like
1104:search
1102:PubMed
945:P98063
926:P13497
822:Entrez
547:BioGPS
234:8p21.3
126:112264
2640:Other
2631:MMP28
2626:MMP27
2621:MMP26
2616:MMP25
2611:MMP24
2596:MMP21
2591:MMP20
2586:MMP19
2581:MMP17
2576:MMP16
2571:MMP15
2566:MMP14
2561:MMP13
2556:MMP12
2551:MMP11
2546:MMP10
2394:ADAM8
2389:ADAM7
2384:ADAM2
2362:ADAM9
1875:S2CID
1760:S2CID
1718:39418
1670:S2CID
1461:(PDF)
1454:(PDF)
855:12153
815:Mouse
810:Human
781:Amigo
521:molar
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
142:55955
134:88176
2541:MMP7
2536:MMP3
2529:MMP9
2524:MMP2
2512:MMP8
2507:MMP1
2284:The
2274:PCP2
2268:PCP2
2255:BMP1
2249:BMP1
2218:PMID
2173:PMID
2138:PMID
2103:PMID
2068:PMID
2015:PMID
1980:PMID
1945:PMID
1910:PMID
1867:PMID
1830:PMID
1795:PMID
1752:PMID
1723:PMID
1662:PMID
1625:PMID
1596:PMID
1567:PMID
1532:PMID
1503:PMID
1433:PMID
1409:3EDG
1387:PMID
1203:and
1185:TGFβ
1161:gene
1158:BMP1
1150:BMP1
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
150:BMP1
122:OMIM
109:BMP1
79:3EDH
75:3EDG
56:RCSB
53:PDBe
22:BMP1
2208:PMC
2198:doi
2163:doi
2128:doi
2124:278
2093:doi
2089:278
2058:PMC
2048:doi
2005:doi
2001:277
1970:doi
1966:277
1935:doi
1931:277
1900:doi
1896:276
1859:doi
1847:410
1820:doi
1816:275
1785:doi
1781:213
1744:doi
1713:PMC
1703:doi
1654:doi
1642:271
1617:doi
1588:doi
1557:doi
1553:269
1524:doi
1520:242
1493:doi
1425:doi
1421:384
1405:PDB
1377:doi
1205:III
1195:of
836:649
497:lip
352:End
251:End
154:OMA
130:MGI
46:PDB
2699::
2337:EC
2331::
2216:.
2206:.
2192:.
2188:.
2171:.
2159:36
2157:.
2153:.
2136:.
2122:.
2118:.
2101:.
2087:.
2083:.
2066:.
2056:.
2046:.
2036:99
2034:.
2030:.
2013:.
1999:.
1995:.
1978:.
1964:.
1960:.
1943:.
1929:.
1925:.
1908:.
1894:.
1890:.
1873:.
1865:.
1857:.
1845:.
1828:.
1814:.
1810:.
1793:.
1779:.
1775:.
1758:.
1750:.
1740:76
1738:.
1721:.
1711:.
1701:.
1691:93
1689:.
1685:.
1668:.
1660:.
1652:.
1640:.
1623:.
1613:29
1611:.
1594:.
1584:64
1582:.
1565:.
1551:.
1547:.
1530:.
1518:.
1501:.
1487:.
1483:.
1431:.
1419:.
1407::
1385:.
1371:.
1367:.
1341:^
1331:.
1313:.
1284:^
1263:^
1246:A
1201:II
1199:,
1167:.
783:/
358:bp
345:bp
257:bp
244:bp
152:;
148::
144:;
140::
136:;
132::
128:;
124::
77:,
2342:)
2335:(
2321:e
2314:t
2307:v
2281:.
2262:.
2224:.
2200::
2194:5
2179:.
2165::
2144:.
2130::
2109:.
2095::
2074:.
2050::
2042::
2021:.
2007::
1986:.
1972::
1951:.
1937::
1916:.
1902::
1881:.
1861::
1853::
1836:.
1822::
1801:.
1787::
1766:.
1746::
1729:.
1705::
1697::
1676:.
1656::
1648::
1631:.
1619::
1602:.
1590::
1573:.
1559::
1538:.
1526::
1509:.
1495::
1489:9
1439:.
1427::
1393:.
1379::
1373:9
1352:.
1335:.
1317:.
276:)
173:)
156::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
