1626:
muscles functioning after the left side of the forehead was paralyzed during a facelift procedure. This patient had desired to look better from her facelift, but was experiencing bizarre unilateral right forehead eyebrow elevation while the left eyebrow drooped, and she constantly demonstrated deep expressive right forehead wrinkles while the left side was perfectly smooth due to the paralysis. Clark was aware that
Botulinum toxin was safely being used to treat babies with strabismus and he requested and was granted FDA approval to experiment with Botulinum toxin to paralyze the moving and wrinkling normal functioning right forehead muscles to make both sides of the forehead appear the same. This study and case report of the cosmetic use of Botulinum toxin to treat a cosmetic complication of a cosmetic surgery was the first report on the specific treatment of wrinkles and was published in the journal
2074:
muscles functioning after the left side of the forehead was paralyzed during a facelift procedure. This patient had desired to look better from her facelift, but was experiencing bizarre unilateral right forehead eyebrow elevation while the left eyebrow drooped and she emoted with deep expressive right forehead wrinkles while the left side was perfectly smooth due to the paralysis. Clark was aware that botulinum toxin was safely being used to treat babies with strabismus and he requested and was granted FDA approval to experiment with botulinum toxin to paralyze the moving and wrinkling normal functioning right forehead muscles to make both sides of the forehead appear the same. This study and case report on the cosmetic use of botulinum toxin to treat a cosmetic complication of a cosmetic surgery was the first report on the specific treatment of wrinkles and was published in the journal
1108:. Side effects are not limited to direct paralysis, however, and can also include headaches, flu-like symptoms, and allergic reactions. Just as cosmetic treatments only last a number of months, paralysis side effects can have the same durations. At least in some cases, these effects are reported to dissipate in the weeks after treatment. Bruising at the site of injection is not a side effect of the toxin, but rather of the mode of administration, and is reported as preventable if the clinician applies pressure to the injection site; when it occurs, it is reported in specific cases to last 7–11 days. When injecting the masseter muscle of the jaw, loss of muscle function can result in a loss or reduction of power to chew solid foods. With continued high doses, the muscles can atrophy or lose strength; research has shown that those muscles rebuild after a break from Botox.
1124:
muscle spasticity in children treated for cerebral palsy. In 2009, the FDA announced that boxed warnings would be added to available botulinum toxin products, warning of their ability to spread from the injection site. However, the clinical use of botulinum toxin A in cerebral palsy children has been proven to be safe with minimal side effects. Additionally, the FDA announced name changes to several botulinum toxin products, to emphasize that the products are not interchangeable and require different doses for proper use. Botox and Botox
Cosmetic were given the generic name of onabotulinumtoxinA, Myobloc as rimabotulinumtoxinB, and Dysport retained its generic name of abobotulinumtoxinA. In conjunction with this, the FDA issued a communication to health care professionals reiterating the new drug names and the approved uses for each. A similar warning was issued by
1637:, observed that blepharospasm patients who received injections around the eyes and upper face also enjoyed diminished facial glabellar lines ("frown lines" between the eyebrows). Alastair Carruthers reported that others at the time also noticed these effects and discussed the cosmetic potential of botulinum toxin. Unlike other investigators, the Carruthers did more than just talk about the possibility of using botulinum toxin cosmetically. They conducted a clinical study on otherwise normal individuals whose only concern was their eyebrow furrow. They performed their study between 1987 and 1989 and presented their results at the 1990 annual meeting of the American Society for Dermatologic Surgery. Their findings were subsequently published in 1992.
1170:. Other tests, such as brain scan and spinal fluid examination, may help to rule out other causes. If the symptoms of botulism are diagnosed early, various treatments can be administered. In an effort to remove contaminated food that remains in the gut, enemas or induced vomiting may be used. For wound infections, infected material may be removed surgically. Botulinum antitoxin is available and may be used to prevent the worsening of symptoms, though it will not reverse existing nerve damage. In severe cases, mechanical respiration may be used to support people with respiratory failure. The nerve damage heals over time, generally over weeks to months. With proper treatment, the case fatality rate for botulinum poisoning can be greatly reduced.
1028:
1064:
neuromuscular blocking agent. The FDA approved daxibotulinumtoxinA based on evidence from two clinical trials (Studies GL-1 and GL-2), of 609 adults with moderate to severe glabellar lines. The trials were conducted at 30 sites in the United States and Canada. Both trials enrolled participants 18 to 75 years old with moderate to severe glabellar lines. Participants received a single intramuscular injection of daxibotulinumtoxinA or placebo at five sites within the muscles between the eyebrows. The most common side effects of daxibotulinumtoxinA are headache, drooping eyelids, and weakness of facial muscles.
951:, otherwise known as improper eye alignment, is caused by imbalances in the actions of muscles that rotate the eyes. This condition can sometimes be relieved by weakening a muscle that pulls too strongly, or pulls against one that has been weakened by disease or trauma. Muscles weakened by toxin injection recover from paralysis after several months, so injection might seem to need to be repeated, but muscles adapt to the lengths at which they are chronically held, so that if a paralyzed muscle is stretched by its antagonist, it grows longer, while the antagonist shortens, yielding a permanent effect.
1068:
BLESS III ) of 1,271 participants with moderate to severe wrinkles between the eyebrows for efficacy and safety assessment. These trials were conducted at 31 sites in the United States and the
European Union. All three trials enrolled participants 18 to 75 years old with moderate to severe glabellar lines (wrinkles between the eyebrows). Participants received a single intramuscular injection of letibotulinumtoxinA or placebo at five sites within the muscles between the eyebrows. The most common side effects of letibotulinumtoxinA are headache, drooping of eyelid and brow, and twitching of eyelid.
514:
1672:
1618:
1194:
1435:. He also performed experiments on animals with ham extracts, isolated bacterial cultures, and toxins extracts from the bacteria. From these he concluded that the bacteria themselves do not cause foodborne botulism, but rather produce a toxin that causes the disease after it is ingested. As a result of Kerner's and van Ermengem's research, it was thought that only contaminated meat or fish could cause botulism. This idea was refuted in 1904 when a botulism outbreak occurred in
1809:
1964:
13714:
10988:
31:
14439:
1481:
2154:(MHRA) for the treatment of ankle disability due to lower limb spasticity associated with stroke in adults. Joint motion may be restricted by severe muscle imbalance related to the syndrome, when some muscles are markedly hypertonic, and lack effective active lengthening. Injecting an overactive muscle to decrease its level of contraction can allow improved reciprocal motion, so improved ability to move and exercise.
1891:, is also available for both therapeutic and cosmetic use in the US. Lanzhou Institute of Biological Products in China manufactures a botulinum toxin type-A product; as of 2014, it was the only botulinum toxin type-A approved in China. Botulinum toxin type-A is also sold as Lantox and Prosigne on the global market. Neuronox, a botulinum toxin type-A product, was introduced by Medy-Tox of South Korea in 2009.
1304:(from several weeks to months). Existing toxin types can recombine to create "hybrid" (mosaic, chimeric) types. Examples include BoNT/CD, BoNT/DC, and BoNT/FA, with the first letter indicating the light chain type and the latter indicating the heavy chain type. BoNT/FA received considerable attention under the name "BoNT/H", as it was mistakenly thought it could not be neutralized by any existing antitoxin.
14451:
8501:
8137:
7351:
6443:
5383:
5180:
4699:
4618:
4153:
1593:, and assuring sterility, potency, and safety, Scott applied to the FDA for investigational drug use, and began manufacturing botulinum type A neurotoxin in his San Francisco lab. He injected the first strabismus patients in 1977, reported its clinical utility in 1980, and had soon trained hundreds of ophthalmologists in EMG-guided injection of the drug he named Oculinum ("eye aligner").
1765:. It can be absorbed through the eyes, mucous membranes, respiratory tract, and non-intact skin. The effects of botulinum toxin are different from those of nerve agents involved insofar in that botulism symptoms develop relatively slowly (over several days), while nerve agent effects are generally much more rapid. Evidence suggests that nerve exposure (simulated by injection of
1537:, a Swiss-American veterinary scientist, created a center at the Hooper Foundation in San Francisco, where he developed techniques for growing the organism and extracting the toxin, and conversely, for preventing organism growth and toxin production, and inactivating the toxin by heating. The California canning industry was thereby preserved.
1950:. Botulism is nevertheless known to be transmitted through canned foods not cooked correctly before canning or after can opening, so is preventable. Infant botulism arising from consumption of honey or any other food that can carry these spores can be prevented by eliminating these foods from diets of children less than 12 months old.
4639:
2081:
J. D. and J. A. Carruthers also studied and reported in 1992 the use of botulinum toxin type-A as a cosmetic treatment. They conducted a study of participants whose only concern was their glabellar forehead wrinkle or furrow. Study participants were otherwise normal. Sixteen of seventeen participants
1777:
detection equipment (such as M-8 paper or the ICAM) will not indicate a "positive" when samples containing botulinum toxin are tested. To confirm a diagnosis of botulinum toxin poisoning, therapeutically or to provide evidence in death investigations, botulinum toxin may be quantitated by immunoassay
1752:
Standard areas for aesthetics botox injections include facial and other areas that can form fine lines and wrinkles due to every day muscle contractions and/or facial expressions such as smiling, frowning, squinting, and raising eyebrows. These areas include the glabellar region between the eyebrows,
1735:
In the US, botox for medical purposes is usually covered by insurance if deemed medically necessary by a doctor and covers a plethora of medical problems including overactive bladder (OAB), urinary incontinence due to neurologic conditions, headaches and migraines, TMJ, spasticity in adults, cervical
1123:
In response to the occurrence of these side effects, in 2008, the FDA notified the public of the potential dangers of the botulinum toxin as a therapeutic. Namely, the toxin can spread to areas distant from the site of injection and paralyze unintended muscle groups, especially when used for treating
2050:
In 1986, Scott's micromanufacturer and distributor of Botox was no longer able to supply the drug because of an inability to obtain product liability insurance. People became desperate, as supplies of Botox were gradually consumed, forcing him to abandon people who would have been due for their next
1596:
In 1986, Oculinum Inc, Scott's micromanufacturer and distributor of botulinum toxin, was unable to obtain product liability insurance, and could no longer supply the drug. As supplies became exhausted, people who had come to rely on periodic injections became desperate. For four months, as liability
2203:
on 15 October 2010. The toxin is injected into the head and neck to treat these chronic headaches. Approval followed evidence presented to the agency from two studies funded by
Allergan showing a very slight improvement in incidence of chronic migraines for those with migraines undergoing the Botox
841:
The seven main types of botulinum toxin are named types A to G (A, B, C1, C2, D, E, F and G). New types are occasionally found. Types A and B are capable of causing disease in humans, and are also used commercially and medically. Types C–G are less common; types E and F can cause disease in humans,
1404:
published the first complete description of the symptoms of botulism, based on extensive clinical observations and animal experiments. He concluded that the toxin develops in bad sausages under anaerobic conditions, is a biological substance, acts on the nervous system, and is lethal even in small
1111:
Side effects from therapeutic use can be much more varied depending on the location of injection and the dose of toxin injected. In general, side effects from therapeutic use can be more serious than those that arise during cosmetic use. These can arise from paralysis of critical muscle groups and
1648:
reported in 2000 that people who had cosmetic injections around the face reported relief from chronic headache. This was initially thought to be an indirect effect of reduced muscle tension, but the toxin is now known to inhibit release of peripheral nociceptive neurotransmitters, suppressing the
1299:
The seven toxin serotypes (A–G) are traditionally separated by their antigenicity. They have different tertiary structures and sequence differences. While the different toxin types all target members of the SNARE family, different toxin types target different SNARE family members. The A, B, and E
1067:
LetibotulinumtoxinA (Letybo) was approved for medical use in the United States in
February 2024. It is indicated to temporarily improve the appearance of moderate-to-severe glabellar lines. The FDA approved letibotulinumtoxinA based on evidence from three clinical trials (BLESS I , BLESS II , and
2086:
frown lines was published in 1992. This result was subsequently confirmed by other groups (Brin, and the
Columbia University group under Monte Keen). The FDA announced regulatory approval of botulinum toxin type A (Botox Cosmetic) to temporarily improve the appearance of moderate-to-severe frown
2211:
who exhibit headache characteristics consistent with: pressure perceived from outside source, shorter total duration of chronic migraines (<30 years), "detoxification" of participants with coexisting chronic daily headache due to medication overuse, and no current history of other preventive
2073:
The effect of botulinum toxin type-A on reducing and eliminating forehead wrinkles was first described and published by
Richard Clark, MD, a plastic surgeon from Sacramento, California. In 1987 Clark was challenged with eliminating the disfigurement caused by only the right side of the forehead
1625:
The effect of botulinum toxin type-A on reducing and eliminating forehead wrinkles was first described and published by
Richard Clark, MD, a plastic surgeon from Sacramento, California. In 1987 Clark was challenged with eliminating the disfigurement caused by only the right side of the forehead
1063:
DaxibotulinumtoxinA (Daxxify) was approved for medical use in the United States in
September 2022. It is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines (wrinkles between the eyebrows). DaxibotulinumtoxinA is an acetylcholine release inhibitor and
1059:
lines ('11's lines' between the eyes) typically last two to four months and in some cases, product-dependent, with some patients experiencing a longer duration of effect of up to six months or longer. Injection of botulinum toxin into the muscles under facial wrinkles causes relaxation of those
1878:
approved by
Government agencies around the world" with less than one gram of raw botulinum toxin. Myobloc or Neurobloc, a botulinum toxin type B product, is produced by Solstice Neurosciences, a subsidiary of US WorldMeds. AbobotulinumtoxinA), a therapeutic formulation of the type A toxin
1100:
While botulinum toxin is generally considered safe in a clinical setting, serious side effects from its use can occur. Most commonly, botulinum toxin can be injected into the wrong muscle group or with time spread from the injection site, causing temporary paralysis of unintended muscles.
965:(FDA) approved abobotulinumtoxinA (Dysport) for injection for the treatment of lower-limb spasticity in pediatric patients two years of age and older. AbobotulinumtoxinA is the first and only FDA-approved botulinum toxin for the treatment of pediatric lower limb spasticity. In the US, the
1556:
The mechanism of botulinum toxin action – blocking the release of the neurotransmitter acetylcholine from nerve endings – was elucidated in the mid-20th century, and remains an important research topic. Nearly all toxin treatments are based on this effect in various body tissues.
1253:(proteins that mediate vesicle fusion, with their target membrane bound compartments) meaning that the acetylcholine vesicles cannot bind to the intracellular cell membrane, preventing the cell from releasing vesicles of neurotransmitter. This stops nerve signaling, leading to
1709:
The global market for botulinum toxin products, driven by their cosmetic applications, was forecast to reach $ 2.9 billion by 2018. The facial aesthetics market, of which they are a component, was forecast to reach $ 4.7 billion ($ 2 billion in the US) in the same timeframe.
1999:. The organism is also susceptible to high salt, high oxygen, and low pH levels. The toxin itself is rapidly destroyed by heat, such as in thorough cooking. The spores that produce the toxin are heat-tolerant and will survive boiling water for an extended period of time.
3888:
Mangera A, Andersson KE, Apostolidis A, Chapple C, Dasgupta P, Giannantoni A, et al. (October 2011). "Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of botox (onabotulinumtoxinA) and dysport (abobotulinumtoxinA)".
1060:
muscles, resulting in the smoothing of the overlying skin. Smoothing of wrinkles is usually visible three to five days after injection, with maximum effect typically a week following injection. Muscles can be treated repeatedly to maintain the smoothed appearance.
1405:
amounts. Kerner hypothesized that this "sausage toxin" could be used to treat a variety of diseases caused by an overactive nervous system, making him the first to suggest that it could be used therapeutically. In 1870, the German physician Müller coined the term
8551:
Dodick DW, Turkel CC, DeGryse RE, Aurora SK, Silberstein SD, Lipton RB, et al. (June 2010). "OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program".
2087:
lines between the eyebrows (glabellar lines) in 2002 after extensive clinical trials. Well before this, the cosmetic use of botulinum toxin type A became widespread. The results of Botox Cosmetic can last up to four months and may vary with each patient. The US
4635:
2046:
and strabismus. Side effects in treatment of this condition were deemed to be rare, mild and treatable. The beneficial effects of the injection lasted only four to six months. Thus, blepharospasm patients required re-injection two or three times a year.
1866:
Commercial forms are marketed under the brand names Botox (onabotulinumtoxinA), Dysport/Azzalure (abobotulinumtoxinA), Letybo (letibotulinumtoxinA), Myobloc (rimabotulinumtoxinB), Xeomin/Bocouture (incobotulinumtoxinA), and Jeuveau (prabotulinumtoxinA).
1430:
that occurred at a funeral where people ate pickled and smoked ham; three of them died. By examining the contaminated ham and performing autopsies on the people who died after eating it, van Ermengem isolated an anaerobic microorganism that he called
5335:
6414:
1873:
In the United States, botulinum toxin products are manufactured by a variety of companies, for both therapeutic and cosmetic use. A US supplier reported in its company materials in 2011 that it could "supply the world's requirements for 25
1600:
Based on data from thousands of people collected by 240 investigators, Oculinum Inc (which was soon acquired by Allergan) received FDA approval in 1989 to market Oculinum for clinical use in the United States to treat adult strabismus and
1120:, and in some cases, seizures, respiratory arrest, and death. Additionally, side effects common in cosmetic use are also common in therapeutic use, including trouble swallowing, muscle weakness, allergic reactions, and flu-like syndromes.
11119:
2041:
University-based ophthalmologists in the US and Canada further refined the use of botulinum toxin as a therapeutic agent. By 1985, a scientific protocol of injection sites and dosage had been empirically determined for treatment of
5360:
8114:
7208:
7054:
5290:
5260:
1883:
in the United Kingdom, is licensed for the treatment of focal dystonias and certain cosmetic uses in the US and other countries. LetibotulinumtoxinA (Letybo) was approved for medical use in the United States in February 2024.
1150:
has grown. However, the toxin can also be introduced through an infected wound. In infants, the bacteria can sometimes grow in the intestines and produce botulinum toxin within the intestine and can cause a condition known as
1726:
Botox cost is generally determined by the number of units administered (avg. $ 10–30 per unit) or by the area ($ 200–1000) and depends on expertise of a physician, clinic location, number of units, and treatment complexity.
2643:
4056:
1585:
and colleagues injected botulinum toxin into monkey extraocular muscles. The result was remarkable; a few picograms induced paralysis that was confined to the target muscle, long in duration, and without side effects.
2051:
injection. For a period of four months, American blepharospasm patients had to arrange to have their injections performed by participating doctors at Canadian eye centers until the liability issues could be resolved.
92:
abobotulinumtoxinA, daxibotulinumtoxinA, daxibotulinumtoxinA-lanm, evabotulinumtoxinA, incobotulinumtoxinA, letibotulinumtoxinA, letibotulinumtoxinA-wlbg, onabotulinumtoxinA, prabotulinumtoxinA, relabotulinumtoxinA,
7093:
969:
the text of the labels of prescription medicines and for which medical conditions the drug manufacturer may sell the drug. However, prescribers may freely prescribe them for any condition they wish, also known as
845:
Botulinum toxins are among the most potent toxins known to science. Intoxication can occur naturally as a result of either wound or intestinal infection or by ingesting formed toxin in food. The estimated human
6794:
1926:
which are widely distributed, including in soil and dust. Also, the bacteria can be found inside homes on floors, carpet, and countertops even after cleaning. Complicating the problem is that the taxonomy for
11129:
7276:
5327:
11024:
2469:
1577:
frequently needed repeating, a search was undertaken for non-surgical, injection treatments using various anesthetics, alcohols, enzymes, enzyme blockers, and snake neurotoxins. Finally, inspired by
11089:
7755:
8769:"DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Results from Each of Two Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Studies (SAKURA 1 and SAKURA 2)"
6771:
6425:
4108:
1573:, the electrical signal from an activated muscle, to guide injection) of local anesthetics as a diagnostic technique for evaluating an individual muscle's contribution to an eye movement. Because
1439:, Germany, because of canned white beans. In 1910, the German microbiologist J. Leuchs published a paper showing that the outbreaks in Ellezelles and Darmstadt were caused by different strains of
2078:
in 1989. Editors of the journal of the American Society of Plastic Surgeons have clearly stated "the first described use of the toxin in aesthetic circumstances was by Clark and Berris in 1989."
1630:
in 1989. Editors of the journal of the American Society of Plastic Surgeons have clearly stated "the first described use of the toxin in aesthetic circumstances was by Clark and Berris in 1989."
1185:(serotypes A, B, C, D, E, F, G), which is derived from equine antibodies that have been altered to make them less immunogenic. This antitoxin is effective against all main strains of botulism.
4040:
1400:
led the authorities to issue a public warning against consuming smoked blood sausages in 1802 and to collect case reports of "sausage poisoning". Between 1817 and 1822, the German physician
11139:
1155:. In all cases, the toxin can then spread, blocking nerves and muscle function. In severe cases, the toxin can block nerves controlling the respiratory system or heart, resulting in death.
5368:
4083:
8122:
7216:
7046:
5298:
5268:
2207:
Since then, several randomized control trials have shown botulinum toxin type A to improve headache symptoms and quality of life when used prophylactically for participants with chronic
11124:
5361:"Information for Healthcare Professionals: OnabotulinumtoxinA (marketed as Botox/Botox Cosmetic), AbobotulinumtoxinA (marketed as Dysport) and RimabotulinumtoxinB (marketed as Myobloc)"
1280:
nerve terminals, as well as the domain responsible for mediating translocation of the light chain into the cell cytoplasm as the vacuole acidifies. The light chain is a M27-family zinc
3546:
Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, et al. (February 2001). "Botulinum toxin as a biological weapon: medical and public health management".
6827:
1549:
in Maryland. Carl Lamanna and James Duff developed the concentration and crystallization techniques that Edward J. Schantz used to create the first clinical product. When the Army's
301:
2102:
smiles; the material is injected into the hyperactive muscles of upper lip, which causes a reduction in the upward movement of lip thus resulting in a smile with a less exposure of
1088:. Studies show that botulinum toxin may be injected into arthritic shoulder joints to reduce chronic pain and improve range of motion. The use of botulinum toxin A in children with
4399:
2555:
2525:
11134:
4422:"HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use BOTOX® safely and effectively. See full prescribing information for BOTOX"
3258:
11017:
5291:"Follow-up to the February 8, 2008, Early Communication about an Ongoing Safety Review of Botox and Botox Cosmetic (Botulinum toxin Type A) and Myobloc (Botulinum toxin Type B)"
2409:
2165:
is a condition where oral secretions are unable to be eliminated, causing pooling of saliva in the mouth. This condition can be caused by various neurological syndromes such as
4138:
2633:
7077:
11099:
11084:
11458:
11104:
7657:"Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and F and Clostridium butyricum type E strains"
6389:
5135:
3683:
2930:
2891:
2861:
2796:
5261:"Update of Safety Review of OnabotulinumtoxinA (marketed as Botox/Botox Cosmetic), AbobotulinumtoxinA (marketed as Dysport) and RimabotulinumtoxinB (marketed as Myobloc)"
11504:
7921:
Flanders M, Tischler A, Wise J, Williams F, Beneish R, Auger N (June 1987). "Injection of type A botulinum toxin into extraocular muscles for correction of strabismus".
7138:
M8 paper is a chemically-treated, dye-impregnated paper used to detect liquid substances for the presence of V- and G-type nerve agents and H- and L-type blister agents.
5770:
Hill KK, Smith TJ (2013). "Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes". In Rummel A, Binz T (eds.).
2826:
1946:
allows the spores to germinate, after which the bacteria can multiply and produce toxin. Critically, ingestion of toxin rather than spores or vegetative bacteria causes
11010:
752:
6798:
5497:
5208:
1553:
was disbanded, Schantz moved to the Food Research Institute in Wisconsin, where he manufactured toxin for experimental use and provided it to the academic community.
6890:
1324:
1260:
The toxin itself is released from the bacterium as a single chain, then becomes activated when cleaved by its own proteases. The active form consists of a two-chain
1233:. As the vesicle moves farther into the cell, it acidifies, activating a portion of the toxin that triggers it to push across the vesicle membrane and into the cell
6860:
6644:
Binder WJ, Brin MF, Blitzer A, Schoenrock LD, Pogoda JM (December 2000). "Botulinum toxin type A (Botox) for treatment of migraine headaches: an open-label study".
4636:"Revance Announces FDA Approval of Daxxify (DaxibotulinumtoxinA-lanm) for Injection, the First and Only Peptide-Formulated Neuromodulator With Long-Lasting Results"
11094:
7268:
3973:
Duthie JB, Vincent M, Herbison GP, Wilson DI, Wilson D (December 2011). Duthie JB (ed.). "Botulinum toxin injections for adults with overactive bladder syndrome".
838:. The toxin is also used commercially for medical and cosmetic purposes. Botulinum toxin is an acetylcholine release inhibitor and a neuromuscular blocking agent.
8255:
1296:
acetylcholine from axon endings. This blockage is slowly reversed as the toxin loses activity and the SNARE proteins are slowly regenerated by the affected cell.
4684:
4603:
7246:
6687:
Jackson JL, Kuriyama A, Hayashino Y (April 2012). "Botulinum toxin A for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis".
9633:
2461:
12692:
255:
7336:
12697:
7740:
5328:"OnabotulinumtoxinA (marketed as Botox/Botox Cosmetic), AbobotulinumtoxinA (marketed as Dysport) and RimabotulinumtoxinB (marketed as Myobloc) Information"
5157:
1426:
and confirmed that a toxin produced by the bacteria causes botulism. On 14 December 1895, there was a large outbreak of botulism in the Belgian village of
6957:
6779:
5230:
4728:
4432:
1104:
Side effects from cosmetic use generally result from unintended paralysis of facial muscles. These include partial facial paralysis, muscle weakness, and
12597:
12593:
12589:
12585:
12562:
12558:
6105:
4100:
2151:
955:
7306:
3293:"Botulinum Toxin A Injection in Treatment of Upper Limb Spasticity in Children with Cerebral Palsy: A Systematic Review of Randomized Controlled Trials"
1533:
Over the next three decades, 1895–1925, as food canning was approaching a billion-dollar-a-year industry, botulism was becoming a public health hazard.
1276:
to a 50-kDa light chain polypeptide. The heavy chain contains domains with several functions; it has the domain responsible for binding specifically to
1213:
Botulinum toxin exerts its effect by cleaving key proteins required for nerve activation. First, the toxin binds specifically to presynaptic surface of
1753:
horizontal lines on the forehead, crow's feet around the eyes, and even circular bands that form around the neck secondary to platysmal hyperactivity.
584:
8478:
6920:
11109:
4556:
1146:(an anaerobic, gram-positive bacterium) is the cause of botulism. Humans most commonly ingest the toxin from eating improperly canned foods in which
5923:
Erbguth FJ (March 2004). "Historical notes on botulism, Clostridium botulinum, botulinum toxin, and the idea of the therapeutic use of the toxin".
2611:
2243:
1460:
8219:
1702:
As of 2018, botulinum toxin injections are the most common cosmetic operation, with 7.4 million procedures in the United States, according to the
13763:
12409:
11364:
11222:
3223:
8154:
Giesler M (2012). "How Doppelgänger Brand Images Influence the Market Creation Process: Longitudinal Insights from the Rise of Botox Cosmetic".
4080:
12149:
12145:
12141:
12137:
11374:
11331:
11282:
1819:
8638:
Magid M, Keeling BH, Reichenberg JS (November 2015). "Neurotoxins: Expanding Uses of Neuromodulators in Medicine--Major Depressive Disorder".
2169:, intellectual disability, and cerebral palsy. Injection of botulinum toxin type-A into salivary glands is useful in reducing the secretions.
11759:
11336:
11202:
4325:
771:
98:
8529:
8071:
Keen M, Kopelman JE, Aviv JE, Binder W, Brin M, Blitzer A (April 1994). "Botulinum toxin A: a novel method to remove periorbital wrinkles".
11317:
11217:
8710:
Finzi E, Rosenthal NE (May 2014). "Treatment of depression with onabotulinumtoxinA: a randomized, double-blind, placebo controlled trial".
6820:
2111:
8220:"Allergan Receives FDA Approval for First-of-Its-Kind, Fully in vitro, Cell-Based Assay for Botox and Botox Cosmetic (onabotulinumtoxinA)"
4459:"Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect"
2082:
available for follow-up demonstrated a cosmetic improvement. This study was reported at a meeting in 1991. The study for the treatment of
12328:
12009:
11994:
11984:
11979:
11974:
11969:
11964:
11959:
11954:
11493:
11433:
11423:
11287:
11187:
4391:
3250:
2547:
2517:
7478:
12074:
9008:
7712:
7576:
5463:
5426:
3442:
5969:
Erbguth FJ, Naumann M (November 1999). "Historical aspects of botulinum toxin: Justinus Kerner (1786-1862) and the "sausage poison"".
2401:
14476:
11819:
11307:
10580:
7379:
4928:"Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases"
4130:
5408:
3407:
1870:
Botulinum toxin A is sold under the brand names Jeuveau, Botox, and Xeomin. Botulinum toxin B is sold under the brand name Myobloc.
14044:
13515:
12014:
7122:
2495:
2185:
in December 2000. Brand names for botulinum toxin type-B include Myobloc in the United States and Neurobloc in the European Union.
1887:
Besides the three primary US manufacturers, numerous other botulinum toxin producers are known. Xeomin, manufactured in Germany by
13783:
1718:
In 2020, 4,401,536 botulinum toxin Type A procedures were administered. In 2019 the botulinum toxin market made US$ 3.19 billion.
1039:, especially in the uppermost third of the face. Commercial forms are marketed under the brand names Botox Cosmetic/Vistabel from
764:
11774:
11649:
6990:
6379:
5118:
2733:
2703:
2221:
5519:
Barash JR, Arnon SS (January 2014). "A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins".
5467:
3679:
2922:
2883:
2853:
2788:
2763:
2673:
2286:
9663:
3173:
Rosales RL, Bigalke H, Dressler D (February 2006). "Pharmacology of botulinum toxin: differences between type A preparations".
3000:
Figgitt DP, Noble S (2002). "Botulinum toxin B: a review of its therapeutic potential in the management of cervical dystonia".
1736:
dystonia in adults, severe axillary hyperhidrosis (or other areas of the body), blepharospasm, upper or lower limb spasticity.
2818:
715:
14511:
14105:
8688:
7192:
7159:
7087:
6460:
Wellman-Labadie O, Zhou Y (May 2010). "The US Orphan Drug Act: rare disease research stimulator or commercial opportunity?".
5787:
4050:
2036:
881:
Botulinum toxin is used to treat a number of therapeutic indications, many of which are not part of the approved drug label.
8402:
Mazzuco R, Hexsel D (December 2010). "Gummy smile and botulinum toxin: a new approach based on the gingival exposure area".
5400:
2321:
2106:. Botox is usually injected in the three lip elevator muscles that converge on the lateral side of the ala of the nose; the
9091:
6127:
Lamanna C, McELROY OE, Eklund HW (May 1946). "The purification and crystallization of Clostridium botulinum type A toxin".
5489:
5200:
1703:
591:
196:
6882:
3632:"Efficacy and Safety of Botulinum Toxin Type A in Spasticity Caused by Spinal Cord Injury: A Randomized, Controlled Trial"
2439:
1773:) will increase mortality by enhancing botulinum toxin's mechanism of toxicity. With regard to detection, protocols using
1173:
Two preparations of botulinum antitoxins are available for treatment of botulism. Trivalent (serotypes A, B, E) botulinum
13792:
13756:
12730:
12571:
12484:
9790:
9051:
6852:
6498:
Clark RP, Berris CE (August 1989). "Botulinum toxin: a treatment for facial asymmetry caused by facial nerve paralysis".
5430:
8245:
7013:
1292:. The cleaved SNAP-25 cannot mediate fusion of vesicles with the host cell membrane, thus preventing the release of the
14471:
12540:
11344:
7582:
6332:
Scott AB (October 1980). "Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery".
1284:
and is the active part of the toxin. It is translocated into the host cell cytoplasm where it cleaves the host protein
6219:
Magoon E, Cruciger M, Scott AB, Jampolsky A (May 1982). "Diagnostic injection of Xylocaine into extraocular muscles".
4672:
4591:
3094:
Janes LE, Connor LM, Moradi A, Alghoul M (April 2021). "Current Use of Cosmetic Toxins to Improve Facial Aesthetics".
14158:
9919:
9911:
7238:
2181:, but it can become ineffective after a time. Botulinum toxin type B received FDA approval for treatment of cervical
2015:
1853:
1520:
966:
11624:
9915:
9803:
9655:
9213:
1498:
10018:
9889:
9076:
7328:
1226:
1006:
709:
286:
177:
7948:"Botulinum toxin therapy of eye muscle disorders. Safety and effectiveness. American Academy of Ophthalmology".
7175:
McAdams D, Kornblet S (2011). "Baader-Meinhof Group (OR Baader-Meinhof Gang". In Pilch RF, Zilinskas RA (eds.).
6609:
Carruthers JD, Carruthers JA (January 1992). "Treatment of glabellar frown lines with C. botulinum-A exotoxin".
5165:
13749:
11163:
10708:
10665:
9001:
6942:
5238:
4955:
4716:
4421:
2194:
1502:
1182:
691:
6101:
1159:
1035:
In cosmetic applications, botulinum toxin is considered relatively safe and effective for reduction of facial
889:
Botulinum toxin is used to treat a number of disorders characterized by overactive muscle movement, including
696:
14314:
13730:
11839:
10170:
9814:
9809:
8750:
for "An Exploratory Study of the Safety and Efficacy of Botox for the Treatment of Premature Ejaculation" at
7298:
1597:
issues were resolved, American blepharospasm patients traveled to Canadian eye centers for their injections.
6066:
Pellett S (June 2012). "Learning from the past: historical aspects of bacterial toxins as pharmaceuticals".
14110:
13720:
12687:
12426:
11040:
9041:
9031:
8486:
8482:
8118:
7749:
7332:
7302:
7242:
7212:
6953:
6421:
5364:
5331:
5294:
5264:
5234:
5161:
4722:
4678:
4597:
4134:
2088:
1795:, which makes botulinum toxin. Their reports were later found to be incorrect; no such lab was ever found.
962:
509:
444:
7718:
6912:
4548:
2091:(FDA) approved an alternative product-safety testing method in response to increasing public concern that
776:
11634:
2373:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2253:
2003:
1019:. However, the use of botulinum toxin injections for episodic migraine has not been approved by the FDA.
684:
244:
2603:
2577:
958:
for treatment of restricted ankle motion due to lower-limb spasticity associated with stroke in adults.
14429:
14004:
13999:
13660:
12319:
12297:
9929:
8767:
Carruthers JD, Fagien S, Joseph JH, Humphrey SD, Biesman BS, Gallagher CJ, et al. (January 2020).
8223:
6254:
Drachman DB (August 1964). "Atrophy of Skeletal Muscle in Chick Embryos Treated with Botulinum Toxin".
2696:"Alluzience, 200 Speywood units/ml, solution for injection - Summary of Product Characteristics (SmPC)"
2231:
2054:
In December 1989, Botox was approved by the US FDA for the treatment of strabismus, blepharospasm, and
2006:
and thus deactivated at temperatures greater than 85 °C (185 °F) for five minutes. As a zinc
8439:"Botulinum toxin A for treatment of sialorrhea in children: an effective, minimally invasive approach"
4170:
Pavone V, Testa G, Restivo DA, Cannavò L, Condorelli G, Portinaro NM, et al. (19 February 2016).
3219:
1976:
14501:
14481:
14415:
14402:
14389:
14376:
14363:
14350:
14337:
14299:
13725:
13445:
13138:
13107:
11068:
9520:
8994:
6305:
Scott AB, Rosenbaum A, Collins CC (December 1973). "Pharmacologic weakening of extraocular muscles".
2372:
13342:
11002:
8328:"Surface anatomy of the lip elevator muscles for the treatment of gummy smile using botulinum toxin"
8197:
4750:
Mittal SO, Safarpour D, Jabbari B (February 2016). "Botulinum Toxin Treatment of Neuropathic Pain".
1076:
Botulinum toxin is also used to treat disorders of hyperactive nerves including excessive sweating,
712:
14521:
14516:
14309:
14263:
14206:
14120:
13937:
13780:
13207:
13143:
12514:
12167:
12064:
11789:
10219:
2115:
2107:
1932:
1921:
1835:
1027:
636:
614:
7455:
4317:
3351:"Botulinum toxin type A in the treatment of lower limb spasticity in children with cerebral palsy"
14486:
14211:
13670:
13525:
13430:
13212:
12986:
12808:
12723:
10003:
9991:
9795:
9784:
8519:
8028:
Koudsie S, Coste-Verdier V, Paya C, Chan H, Andrebe C, Pechmeja J, et al. (April 2021). "".
6571:
Carruthers A (November–December 2003). "History of the clinical use of botulinum toxin A and B".
6536:
Rohrich RJ, Janis JE, Fagien S, Stuzin JM (October 2003). "The cosmetic use of botulinum toxin".
1943:
1606:
1491:
1052:
233:
69:
9248:
7606:"Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?"
6943:"BOTOX (onabotulinumtoxinA) for injection, for intramuscular, intradetrusor, or intradermal use"
5816:"Variations in the Botulinum Neurotoxin Binding Domain and the Potential for Novel Therapeutics"
1384:
One of the earliest recorded outbreaks of foodborne botulism occurred in 1793 in the village of
152:
13741:
13485:
13395:
13385:
13322:
12803:
10037:
9975:
9733:
9227:
9188:
9183:
9138:
2756:"Xeomin 50 units powder for solution for injection - Summary of Product Characteristics (SmPC)"
2726:"Letybo 50 units powder for solution for injection - Summary of Product Characteristics (SmPC)"
913:. Similarly, botulinum toxin is used to relax the clenching of muscles, including those of the
827:
144:
13357:
10051:
9270:
8814:"Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A"
7981:"Botulinum toxin in the management of blepharospasm: current evidence and recent developments"
1605:. Allergan then began using the trademark Botox. This original approval was granted under the
14232:
14151:
14095:
13695:
13337:
13148:
12996:
12432:
12353:
10826:
10461:
9822:
9614:
9445:
9198:
9081:
7489:
5557:
Barr JR, Moura H, Boyer AE, Woolfitt AR, Kalb SR, Pavlopoulos A, et al. (October 2005).
2249:
2143:
2135:
1909:
1875:
1791:
1117:
811:
248:
5117:
3434:
1789:
gang safe house in Paris and had found a makeshift laboratory that contained flasks full of
1419:
1084:
symptoms. In addition to these uses, botulinum toxin is being evaluated for use in treating
672:
14506:
14304:
13776:
13680:
13242:
13227:
13163:
12981:
12282:
11629:
11149:
10065:
10013:
9648:
9475:
9178:
9168:
9123:
9113:
9102:
9036:
7877:
6263:
6136:
1831:
1785:
During the early 1980s, German and French newspapers reported that the police had raided a
1534:
1152:
462:
454:
388:
380:
128:
120:
7368:
5678:
4221:
Syed YY (August 2017). "AbobotulinumtoxinA: A Review in Pediatric Lower Limb Spasticity".
3399:
1995:
Proper refrigeration at temperatures below 4.4 °C (39.9 °F) slows the growth of
1975: with: modern content and referencing on antibiotic susceptibilities. You can help by
1392:, Germany. Thirteen people became sick and six died after eating pork stomach filled with
1389:
648:
136:
112:
8:
14268:
13580:
13565:
13332:
13302:
13282:
13018:
12966:
12905:
12443:
12343:
12272:
12089:
12039:
11564:
10991:
9173:
9163:
9133:
9118:
9071:
8915:
8437:
Khan WU, Campisi P, Nadarajah S, Shakur YA, Khan N, Semenuk D, et al. (April 2011).
8250:
7866:"Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins"
5774:. Current Topics in Microbiology and Immunology. Vol. 364. Springer. pp. 1–20.
5231:"FDA Gives Update on Botulinum Toxin Safety Warnings; Established Names of Drugs Changed"
5201:"FDA Gives Update on Botulinum Toxin Safety Warnings; Established Names of Drugs Changed"
2062:
1915:
1827:
1335:
975:
619:
370:
7881:
7115:
6267:
6140:
3466:"Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin"
2491:
2065:
in people younger than 12 years of age, several studies have yielded differing results.
1685:
Please help update this article to reflect recent events or newly available information.
1545:
With the outbreak of World War II, weaponization of botulinum toxin was investigated at
974:. Botulinum toxins have been used off-label for several pediatric conditions, including
513:
14496:
14201:
13153:
12976:
12910:
12828:
12716:
12160:
11864:
11043:
10929:
10099:
10057:
9934:
9765:
9386:
9153:
9148:
9143:
8840:
8795:
8751:
8663:
8620:
8577:
8303:
8278:
8171:
8096:
8053:
8005:
7980:
7898:
7865:
7683:
7656:
7632:
7605:
7428:
7411:
6748:
6723:
6669:
6622:
6584:
6549:
6511:
6384:
6357:
6287:
6196:
6171:
6043:
6018:
5994:
5948:
5893:
5842:
5747:
5687:
5662:
5640:
5583:
5558:
5093:
5076:
5052:
5027:
5003:
4978:
4896:
4869:
4775:
4485:
4458:
4290:
4265:
4246:
4198:
3950:
3925:
3865:
3814:
3789:
3770:
3656:
3631:
3607:
3582:
3523:
3506:
3375:
3350:
3319:
3198:
3119:
3073:
3025:
2127:
1578:
1574:
1214:
937:
847:
207:
7957:
7806:
7781:
7540:
7515:
6982:
6345:
6232:
5459:
2965:
Montecucco C, Molgó J (June 2005). "Botulinal neurotoxins: revival of an old killer".
2725:
2695:
2432:"Nuceiva prabotulinumtoxinA 100 Units Powder for Solution for Injection vial (381094)"
2199:
Onabotulinumtoxin A (trade name Botox) received FDA approval for treatment of chronic
1300:
serotypes cause human botulism, with the activities of types A and B enduring longest
1128:
in 2009, warning that botulinum toxin products can spread to other parts of the body.
727:
14491:
13390:
13272:
13247:
13168:
12843:
12838:
12612:
12554:
12531:
12520:
12059:
11934:
11884:
11834:
11714:
11514:
10974:
note: some toxins are produced by lower species and pass through intermediate species
10934:
10878:
10165:
8975:
8963:
8951:
8939:
8927:
8906:
8894:
8885:
8873:
8864:
8845:
8812:
Solish N, Carruthers J, Kaufman J, Rubio RG, Gross TM, Gallagher CJ (December 2021).
8800:
8727:
8723:
8655:
8612:
8569:
8565:
8460:
8419:
8384:
8349:
8308:
8294:
8175:
8088:
8057:
8045:
8010:
7961:
7930:
7903:
7846:
7811:
7688:
7637:
7545:
7433:
7188:
7155:
7083:
6753:
6704:
6661:
6626:
6588:
6553:
6515:
6477:
6349:
6314:
6279:
6236:
6201:
6152:
6083:
6048:
5986:
5940:
5898:
5847:
5793:
5783:
5752:
5692:
5632:
5588:
5536:
5127:
5098:
5057:
5008:
4947:
4901:
4847:
4816:
4767:
4526:
4490:
4373:
4295:
4238:
4203:
4046:
4021:
3986:
3955:
3906:
3870:
3855:
3838:
3819:
3774:
3762:
3728:
3661:
3612:
3563:
3528:
3487:
3380:
3324:
3190:
3186:
3123:
3111:
3065:
3017:
3013:
2982:
2755:
2665:
2227:
2178:
2011:
1645:
1254:
1163:
1081:
1010:
831:
703:
330:
313:
169:
49:
12616:
8667:
8624:
8100:
7184:
6673:
6473:
6361:
6291:
5998:
5721:"Small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication"
5644:
4779:
4250:
3202:
3048:
Shukla HD, Sharma SK (2005). "Clostridium botulinum: a bug with beauty and weapon".
3029:
1617:
1158:
Botulism can be difficult to diagnose, as it may appear similar to diseases such as
14247:
14242:
14216:
14144:
13500:
13465:
13061:
12951:
12930:
12823:
12753:
12646:
12627:
12323:
12124:
12119:
12114:
12109:
12104:
12099:
12094:
11899:
11779:
11769:
11599:
11057:
10873:
10691:
10297:
10213:
10155:
9961:
9585:
8835:
8825:
8790:
8780:
8719:
8647:
8604:
8581:
8561:
8450:
8411:
8376:
8339:
8298:
8290:
8163:
8080:
8037:
8000:
7992:
7953:
7893:
7885:
7838:
7801:
7793:
7678:
7668:
7627:
7617:
7535:
7527:
7516:"Properties and use of botulinum toxin and other microbial neurotoxins in medicine"
7423:
7180:
6743:
6735:
6696:
6653:
6618:
6580:
6545:
6507:
6469:
6341:
6271:
6228:
6191:
6187:
6183:
6144:
6075:
6038:
6030:
5978:
5952:
5932:
5888:
5878:
5837:
5827:
5775:
5742:
5732:
5682:
5674:
5622:
5578:
5570:
5528:
5088:
5047:
5039:
4998:
4990:
4939:
4891:
4881:
4843:
4839:
4806:
4759:
4480:
4470:
4363:
4285:
4277:
4230:
4193:
4183:
4013:
3982:
3978:
3945:
3937:
3898:
3860:
3850:
3809:
3801:
3718:
3651:
3643:
3602:
3594:
3555:
3518:
3477:
3370:
3366:
3362:
3314:
3304:
3182:
3153:
3103:
3077:
3057:
3009:
2974:
2055:
1364:
1316:
1293:
1113:
1077:
816:
526:
269:
8986:
8746:
8684:
7889:
7797:
7655:
Hill KK, Xie G, Foley BT, Smith TJ, Munk AC, Bruce D, et al. (October 2009).
4811:
4794:
4017:
2462:"Prescription medicines: registration of new chemical entities in Australia, 2014"
2346:
1938:
Food-borne botulism results, indirectly, from ingestion of food contaminated with
22:
14455:
14294:
14278:
14191:
13800:
13640:
13520:
13415:
13400:
13347:
13122:
13112:
12848:
12813:
12464:
12459:
12267:
11554:
11544:
11524:
10956:
10861:
10456:
10111:
10008:
9853:
9713:
9641:
9454:
9440:
9404:
9018:
8785:
8768:
8651:
7531:
6275:
6148:
4281:
4087:
3902:
3723:
3706:
3107:
2819:"Botox Cosmetic- onabotulinumtoxina injection, powder, lyophilized, for solution"
2317:
2166:
2007:
1401:
1281:
1250:
926:
862:
8115:"Botulinum Toxin Type A Product Approval Information – Licensing Action 4/12/02"
7209:"Botulinum Toxin Type A Product Approval Information - Licensing Action 4/12/02"
5779:
4101:"UK's MHRA approves Botox for treatment of ankle disability in stroke survivors"
1237:. Botulinum neurotoxins recognize distinct classes of receptors simultaneously (
731:
14443:
14332:
14273:
13590:
13505:
13455:
13450:
13277:
13173:
13117:
12900:
11874:
11794:
11549:
11519:
11359:
10898:
10446:
10386:
10209:
10201:
9948:
9902:
9671:
9333:
8830:
8813:
8415:
8326:
Hwang WS, Hur MS, Hu KS, Song WC, Koh KS, Baik HS, et al. (January 2009).
5422:
4943:
4834:
Singh JA, Fitzgerald PM (September 2010). "Botulinum toxin for shoulder pain".
4345:
4343:
3158:
3141:
3140:
Al-Ghamdi AS, Alghanemy N, Joharji H, Al-Qahtani D, Alghamdi H (January 2015).
2978:
2431:
2287:"Letybo- letibotulinumtoxina-wlbg injection, powder, lyophilized, for solution"
2131:
1786:
1570:
1550:
1289:
1273:
1089:
890:
747:
35:
13550:
12182:
8608:
8380:
8041:
7842:
6079:
5737:
5720:
4234:
4004:
Scott AB (1994). "Change of eye muscle sarcomeres according to eye position".
3309:
3292:
3220:"Botulism toxin X: Time to update the textbooks, thanks to genomic sequencing"
3061:
2923:"Daxxify- botulinum toxin type a injection, powder, lyophilized, for solution"
2884:"Dysport- botulinum toxin type a injection, powder, lyophilized, for solution"
1397:
1376:
14465:
14237:
14196:
13650:
13645:
13620:
13545:
13460:
13237:
12956:
12798:
12252:
12084:
11859:
11824:
11699:
11354:
11033:
10888:
10831:
10585:
10548:
10496:
10441:
10426:
10302:
10262:
10205:
9999:
9848:
9771:
9550:
9540:
9495:
9490:
9485:
9356:
9313:
9298:
9279:
9238:
8505:
8455:
8438:
8141:
7996:
7829:
Setlow P (April 2007). "I will survive: DNA protection in bacterial spores".
7355:
7269:"Hugel's 'Letybo' First in Korea to Obtain Marketing Approval from Australia"
7023:
6447:
5867:"Identification of a novel botulinum neurotoxin gene cluster in Enterococcus"
5387:
5184:
5131:
4703:
4622:
4188:
4171:
4157:
3805:
3397:
2638:
2126:
Botulinum toxin type-A is now a common treatment for muscles affected by the
2043:
1602:
1582:
1459:
would be only used to describe a group of anaerobic microorganisms. In 1919,
1393:
1358:
1346:
1320:
1312:
1265:
1246:
1242:
1218:
1202:
1125:
999:
987:
971:
902:
858:
819:
722:
502:
343:
240:
13440:
7570:
6657:
5883:
5866:
5532:
4886:
4340:
3559:
3482:
3465:
3291:
Farag SM, Mohammed MO, El-Sobky TA, ElKadery NA, ElZohiery AK (March 2020).
54:
14186:
13570:
13555:
13495:
13405:
13367:
13066:
12961:
12608:
12399:
12292:
12247:
12212:
12202:
12197:
12044:
11924:
11829:
11734:
11559:
11369:
11252:
11237:
10951:
10941:
10924:
10893:
10841:
10805:
10764:
10718:
10655:
10558:
10481:
10416:
10251:
10247:
10243:
10229:
10043:
9879:
9676:
9600:
9459:
9430:
9293:
9288:
9022:
8849:
8804:
8731:
8659:
8616:
8573:
8464:
8423:
8388:
8353:
8312:
8084:
8049:
8014:
7907:
7850:
7692:
7673:
7641:
7622:
7437:
7299:"Drug Approval Package: Xeomin (incobotulinumtoxinA) Injection NDA #125360"
6757:
6708:
6665:
6592:
6557:
6481:
6283:
6205:
6156:
6087:
6052:
5990:
5944:
5902:
5851:
5832:
5815:
5797:
5756:
5696:
5636:
5592:
5574:
5540:
5102:
5061:
5043:
5012:
4994:
4951:
4905:
4851:
4820:
4771:
4763:
4530:
4494:
4377:
4299:
4242:
4207:
4172:"Botulinum Toxin Treatment for Limb Spasticity in Childhood Cerebral Palsy"
3990:
3959:
3910:
3874:
3823:
3766:
3732:
3665:
3616:
3567:
3532:
3491:
3384:
3328:
3194:
3115:
3069:
3021:
2986:
1774:
1762:
1546:
1352:
1193:
1085:
1051:, Xeomin/Bocouture from Merz, Jeuveau/Nuceiva from Evolus, manufactured by
1003:
930:
264:
8092:
7965:
7934:
7815:
7549:
6700:
6630:
6519:
6353:
6318:
6240:
5982:
5719:
Li B, Peet NP, Butler MM, Burnett JC, Moir DT, Bowlin TL (December 2010).
4025:
3788:
Stavropoulos SN, Friedel D, Modayil R, Iqbal S, Grendell JH (March 2013).
14410:
14345:
14181:
14115:
14100:
13945:
13665:
13655:
13435:
13352:
13262:
13257:
13158:
13076:
13028:
12971:
12915:
12833:
12818:
12636:
12474:
12394:
12338:
12232:
12079:
11844:
11744:
11619:
11574:
11418:
11413:
11408:
11341:
11302:
11247:
11232:
11212:
11197:
10914:
10868:
10856:
10713:
10660:
10610:
10516:
10511:
10501:
10466:
10451:
10317:
10028:
9985:
9956:
9776:
9754:
9691:
9681:
9595:
9580:
9570:
9530:
9525:
9510:
9505:
9422:
9394:
9308:
9303:
8595:
Ashkenazi A (March 2010). "Botulinum toxin type a for chronic migraine".
8344:
8327:
6034:
5559:"Botulinum neurotoxin detection and differentiation by mass spectrometry"
4795:"Botulinum neurotoxin serotype A: a clinical update on non-cosmetic uses"
4475:
3941:
3598:
3400:"OnabotulinumtoxinA (Botulinum Toxin Type A) Monograph for Professionals"
2019:
2010:(see below), the toxin's activity is also susceptible, post-exposure, to
1888:
1770:
1409:
to describe the disease caused by sausage poisoning, from the Latin word
1340:
1269:
1238:
1230:
1222:
910:
660:
163:
44:
12177:
6821:"2020 National Plastic Surgery Statistics: Cosmetic Surgical Procedures"
4517:
Small R (August 2014). "Botulinum toxin injection for facial wrinkles".
3647:
2789:"Botox- onabotulinumtoxina injection, powder, lyophilized, for solution"
1963:
934:
417:
409:
14090:
13962:
13615:
13610:
13530:
13480:
13475:
13410:
13267:
13097:
13038:
12925:
12778:
12661:
12657:
12389:
12379:
12374:
12287:
12262:
12222:
12217:
12207:
12192:
12133:
12128:
11939:
11799:
11784:
11754:
11729:
11704:
11659:
11654:
11644:
11614:
11584:
11448:
11438:
11383:
11378:
11349:
11326:
11292:
11257:
11242:
11207:
11182:
11036:
10946:
10883:
10800:
10778:
10723:
10686:
10630:
10600:
10590:
10531:
10521:
10506:
10491:
10486:
10471:
10391:
10376:
10292:
10282:
10277:
10267:
10234:
9924:
9884:
9701:
9696:
9622:
9590:
9560:
9545:
9535:
9515:
9376:
9366:
9351:
9341:
8167:
2162:
2147:
1935:
across lineages, contributing to the multi-species pattern seen today.
1566:
1505: in this section. Unsourced material may be challenged and removed.
1427:
1178:
948:
906:
894:
800:
565:
428:
87:
30:
13420:
6772:"New plastic surgery statistics reveal trends toward body enhancement"
6739:
6724:"Therapeutic use of botulinum toxin in migraine: mechanisms of action"
5936:
5627:
5610:
5077:"Minimizing bruising following fillers and other cosmetic injectables"
3753:
Felber ES (October 2006). "Botulinum toxin in primary care medicine".
14384:
14358:
13630:
13575:
13307:
12920:
12884:
12879:
12874:
12773:
12739:
12500:
12384:
12333:
12242:
12237:
12227:
12069:
12004:
11999:
11989:
11944:
11914:
11909:
11894:
11879:
11849:
11814:
11804:
11709:
11589:
11579:
11569:
11539:
11534:
11529:
11453:
11428:
11393:
11322:
11297:
11267:
11227:
11177:
11032:
10851:
10846:
10836:
10816:
10759:
10749:
10744:
10703:
10615:
10431:
10411:
10401:
10361:
10356:
10336:
10307:
10257:
10239:
10192:
10184:
10091:
10075:
9686:
9500:
9371:
9361:
9318:
7780:
Licciardello JJ, Nickerson JT, Ribich CA, Goldblith SA (March 1967).
4368:
4352:"Hyperhidrosis: evolving therapies for a well-established phenomenon"
4351:
1634:
1436:
1234:
1174:
1105:
914:
102:
7779:
7239:"Drug Approval Package: Dysport (abobotulinumtoxin) NDA #125274s000"
4927:
4926:
Coté TR, Mohan AK, Polder JA, Walton MK, Braun MM (September 2005).
1761:
Botulinum toxin has been recognized as a potential agent for use in
1480:
14438:
14125:
13927:
13922:
13917:
13772:
13690:
13675:
13605:
13560:
13470:
13380:
13327:
13312:
13292:
13252:
13222:
13217:
13081:
13071:
13043:
13023:
12869:
12864:
12788:
12783:
12768:
12758:
12667:
12369:
12302:
12257:
12187:
12155:
12054:
12034:
12024:
11889:
11809:
11739:
11724:
11609:
11604:
11509:
11443:
11388:
11312:
11262:
11192:
11172:
10754:
10734:
10645:
10640:
10605:
10595:
10570:
10526:
10476:
10421:
10396:
10381:
10346:
10341:
10272:
10224:
10197:
10143:
10071:
9724:
9565:
9555:
9480:
9412:
9346:
9323:
9063:
8193:
7923:
Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie
7375:
7018:
4321:
4266:"Ten common questions (and their answers) about off-label drug use"
3839:"Efficacy of botulinum toxins on bruxism: an evidence-based review"
3139:
2208:
2200:
2182:
2139:
2083:
1947:
1880:
1766:
1650:
1308:
1137:
1056:
1044:
1040:
1036:
1016:
1013:
986:
AbobotulinumtoxinA has been approved for the treatment of axillary
922:
898:
854:
835:
807:
491:
483:
399:
191:
3887:
13912:
13907:
13902:
13897:
13892:
13887:
13882:
13600:
13425:
13375:
13287:
13013:
13008:
12991:
12935:
12404:
12312:
12277:
12049:
11949:
11919:
11904:
11854:
11749:
11694:
11689:
11684:
11679:
11674:
11669:
11664:
11639:
11594:
11488:
11483:
11403:
11398:
11272:
10909:
10371:
10366:
10351:
10312:
10287:
10124:
10104:
9744:
9575:
9222:
8920:
8910:
8899:
8889:
8878:
8868:
8504:
This article incorporates text from this source, which is in the
8140:
This article incorporates text from this source, which is in the
7354:
This article incorporates text from this source, which is in the
6795:"The global botox market forecast to reach $ 2.9 billion by 2018"
6446:
This article incorporates text from this source, which is in the
5386:
This article incorporates text from this source, which is in the
5183:
This article incorporates text from this source, which is in the
4702:
This article incorporates text from this source, which is in the
4621:
This article incorporates text from this source, which is in the
4156:
This article incorporates text from this source, which is in the
3398:
American Society of Health-System Pharmacists (27 October 2011).
3142:"Botulinum toxin: Non cosmetic and off-label dermatological uses"
1590:
1385:
1288:, a member of the SNARE protein family, which is responsible for
1285:
1277:
1261:
918:
803:
679:
13771:
7706:
7014:"Botulism, Botulinum Toxin, and Bioterrorism: Review and Update"
3464:
Košenina S, Masuyer G, Zhang S, Dong M, Stenmark P (June 2019).
1396:, a local delicacy. Additional cases of fatal food poisoning in
14397:
14167:
14049:
13877:
13872:
13867:
13862:
13857:
13852:
13847:
13842:
13820:
13815:
13810:
13595:
13585:
13535:
13510:
13490:
13362:
13102:
13033:
13001:
12793:
11929:
11719:
11478:
11473:
11468:
11463:
11277:
11051:
10676:
10650:
10620:
10436:
10138:
10119:
9867:
9060:
3787:
3545:
1589:
After working out techniques for freeze-drying, buffering with
1331:
1167:
759:
655:
643:
631:
8766:
7044:
6172:"The action of botulinum toxin on the neuro-muscular junction"
5158:"FDA Notifies Public of Adverse Reactions Linked to Botox Use"
3349:
Blumetti FC, Belloti JC, Tamaoki MJ, Pinto JA (October 2019).
2492:"AusPAR: Letybo | Therapeutic Goods Administration (TGA)"
2098:
Botulinum toxin type-A has also been used in the treatment of
1569:) had developed the method of EMG-guided injection (using the
1455:
should only refer to a group of aerobic microorganisms, while
1055:
in South Korea. The effects of botulinum toxin injections for
14371:
14074:
14069:
14064:
14059:
14054:
14039:
14034:
14029:
14024:
14019:
14014:
14009:
13994:
13989:
13837:
13832:
13827:
13805:
13685:
13635:
13625:
13540:
13317:
13232:
13202:
13197:
12307:
12029:
12019:
11869:
11764:
11114:
10625:
10541:
10536:
10406:
10327:
9666:
7154:. Seal Beach, Ca.: Biomedical Publications. pp. 260–61.
3290:
1818:
deal primarily with the United States and do not represent a
1048:
12708:
11459:
Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)
8905:
Overview of all the structural information available in the
8884:
Overview of all the structural information available in the
8863:
Overview of all the structural information available in the
8811:
8367:
Gracco A, Tracey S (May 2010). "Botox and the gummy smile".
8027:
7920:
7412:"Comparison and overview of currently available neurotoxins"
6218:
1782:
units per milliliter have been detected in poisoned people.
1633:
Also in 1987, Jean and Alastair Carruthers, both doctors in
1344:), which is toxic in mice and possibly in humans; a BoNT/J (
13984:
13979:
13972:
13967:
13955:
13950:
13297:
12572:
12485:
11505:
2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate
10790:
10698:
7479:"Medy-Tox Introduces Neuronox to the Botulinum Toxin Arena"
6643:
3972:
3348:
2146:, decreased movement control, and hypertonicity (including
2103:
2099:
2092:
823:
667:
473:
14136:
12541:
8436:
5865:
Brunt J, Carter AT, Stringer SC, Peck MW (February 2018).
3251:"Study: Novel botulinum toxin less dangerous than thought"
1778:
of human biological fluids; serum levels of 12–24 mouse LD
1463:
used toxin-antitoxin reactions to identify two strains of
1443:
and that the toxins were serologically distinct. In 1917,
1422:, a Belgian microbiologist, discovered what is now called
10635:
8550:
8524:
8190:"Botox Cosmetic (onabotulinumtoxinA) Product Information"
7405:
7403:
7401:
4169:
2380:
2150:). In January 2014, Botulinum toxin was approved by UK's
8189:
6983:"Botox Procedures: What is Botox & How Does it Work"
6686:
6535:
3463:
3093:
2634:"Health Canada New Drug Authorizations: 2016 Highlights"
2252:
has been under development since August 2013, and is in
2095:
testing was required for each batch sold in the market.
8637:
8277:
Nayyar P, Kumar P, Nayyar PV, Singh A (December 2014).
7451:
6604:
6602:
5864:
4586:
4584:
4582:
4580:
4578:
4576:
4574:
3837:
Long H, Liao Z, Wang Y, Liao L, Lai W (February 2012).
3505:
Dhaked RK, Singh MK, Singh P, Gupta P (November 2010).
1565:
Ophthalmologists specializing in eye muscle disorders (
8276:
8070:
7978:
7398:
7047:"Pathogen Safety Data Sheets: Infectious Substances –
5556:
4749:
4667:
4665:
4663:
4661:
4659:
4657:
4349:
3172:
2666:"Azzalure - Summary of Product Characteristics (SmPC)"
2318:"Letybo | Therapeutic Goods Administration (TGA)"
2226:
A few small trials have found benefits in people with
2134:, for muscles with an impaired ability to effectively
1953:
1899:
Botulism toxins are produced by bacteria of the genus
1197:
Target molecules of botulinum neurotoxin (abbreviated
954:
In January 2014, botulinum toxin was approved by UK's
842:
while the other types cause disease in other animals.
14427:
7863:
6304:
5608:
5025:
4976:
4925:
3923:
3504:
2138:. Muscles affected by UMNS frequently are limited by
7075:
6608:
6599:
6126:
4571:
2917:
2915:
2913:
2911:
2909:
2848:
2846:
2844:
815:
and related species. It prevents the release of the
16:
Neurotoxic protein produced by Clostridium botulinum
9016:
6459:
6169:
5718:
5660:
5401:"Botox chemical may spread, Health Canada confirms"
4654:
4263:
3755:
The Journal of the American Osteopathic Association
2365:
2152:
Medicines and Healthcare products Regulatory Agency
956:
Medicines and Healthcare products Regulatory Agency
8443:Archives of Otolaryngology–Head & Neck Surgery
7864:Capková K, Salzameda NT, Janda KD (October 2009).
6564:
5028:"The whole truth about botulinum toxin - a review"
4979:"The whole truth about botulinum toxin - a review"
4463:Clinical, Cosmetic and Investigational Dermatology
2854:"Myobloc- rimabotulinumtoxinb injection, solution"
2783:
2781:
2281:
2279:
2277:
2275:
2273:
2271:
2269:
11069:
8246:"In U.S., Few Alternatives To Testing On Animals"
7654:
7416:The Journal of Clinical and Aesthetic Dermatology
6721:
5763:
5081:The Journal of Clinical and Aesthetic Dermatology
4921:
4919:
4917:
4915:
4549:"Jeuveau, The Most Affordable Wrinkle Injectable"
4264:Wittich CM, Burkle CM, Lanier WL (October 2012).
4006:Journal of Pediatric Ophthalmology and Strabismus
3790:"Endoscopic approaches to treatment of achalasia"
3146:Journal of Dermatology & Dermatologic Surgery
2960:
2958:
2956:
2954:
2952:
2950:
2948:
2906:
2841:
2195:Migraine treatment § Botulinum Toxin (Botox)
14463:
7782:"Thermal inactivation of type E botulinum toxin"
7076:Fleisher LA, Roizen MF, Roizen J (31 May 2017).
7045:Public Health Agency of Canada (19 April 2011).
6611:The Journal of Dermatologic Surgery and Oncology
6380:"Loss Of Drug Relegates Many To Blindness Again"
5813:
5609:Dressler D, Saberi FA, Barbosa ER (March 2005).
5322:
5320:
5318:
5316:
4350:Eisenach JH, Atkinson JL, Fealey RD (May 2005).
4318:"Infantile Esotropia Treatment & Management"
3836:
3580:
2244:List of investigational sexual dysfunction drugs
1649:central pain processing systems responsible for
1249:). Once inside the cytoplasm, the toxin cleaves
1031:Botulinum toxin being injected in the human face
929:, or clenching of the anus which can exacerbate
9059:
8685:"Onabotulinum toxin A - Allergan - AdisInsight"
8679:
8677:
7174:
7152:Disposition of toxic drugs and chemicals in man
6170:Burgen AS, Dickens F, Zatman LJ (August 1949).
6012:
6010:
6008:
5964:
5962:
5918:
5916:
5914:
5912:
5809:
5807:
5656:
5654:
4863:
4861:
4833:
4392:"FDA Approves Botox to Treat Chronic Migraines"
3344:
3342:
3340:
3338:
3089:
3087:
2964:
2778:
2341:
2339:
2266:
2030:
1221:. Once bound to the nerve terminal, the neuron
387:
379:
12414:Many of the other AChE inhibitors listed above
8709:
8479:"FDA approves Botox to treat chronic migraine"
8404:Journal of the American Academy of Dermatology
8325:
7985:Therapeutic Advances in Neurological Disorders
7952:. Suppl (Suppl 37-41): 37–41. September 1989.
7565:
7563:
7561:
7559:
7513:
6016:
5968:
5814:Davies JR, Liu SM, Acharya KR (October 2018).
4932:Journal of the American Academy of Dermatology
4912:
2945:
2312:
2310:
2308:
2121:
1744:Botox for excessive sweating is FDA approved.
933:. Botulinum toxin appears to be effective for
14152:
13757:
12724:
12354:
11018:
9649:
9002:
8520:"FDA approves Botox as migraine preventative"
8401:
8395:
8360:
8319:
8270:
7603:
7011:
6453:
5604:
5602:
5313:
5074:
5026:Witmanowski H, Błochowiak K (December 2020).
4977:Witmanowski H, Błochowiak K (December 2020).
3630:Yan X, Lan J, Liu Y, Miao J (November 2018).
3629:
3507:"Botulinum toxin: Bioweapon & magic drug"
3222:. Boston Children's Hospital. 7 August 2017.
3043:
3041:
3039:
1816:The examples and perspective in this article
1092:is safe in the upper and lower limb muscles.
990:, which cannot be managed by topical agents.
12693:Muscarinic acetylcholine receptor modulators
11150:
9732:
8674:
8366:
8279:"BOTOX: Broadening the Horizon of Dentistry"
6005:
5959:
5909:
5804:
5651:
4858:
4638:(Press release). Revance. 8 September 2022.
4512:
4510:
4508:
4506:
4504:
4315:
3335:
3286:
3284:
3282:
3280:
3278:
3276:
3166:
3135:
3133:
3084:
3047:
2999:
2336:
2112:levator labii superioris alaeque nasi muscle
195:
12698:Nicotinic acetylcholine receptor modulators
12577:Tooltip Vesicle-associated membrane protein
12490:Tooltip Vesicular acetylcholine transporter
12444:
8283:Journal of Clinical and Diagnostic Research
7979:Hellman A, Torres-Russotto D (March 2015).
7556:
7409:
6722:Ramachandran R, Yaksh TL (September 2014).
6497:
5714:
5712:
5710:
5708:
5706:
5661:Dong M, Masuyer G, Stenmark P (June 2019).
5552:
5550:
5518:
5454:
5452:
5450:
5448:
4836:The Cochrane Database of Systematic Reviews
3975:The Cochrane Database of Systematic Reviews
3926:"Anal fissure: a common cause of anal pain"
3355:The Cochrane Database of Systematic Reviews
2305:
1931:remains chaotic. The toxin has likely been
1621:Doctor performing Botulinum toxin injection
1410:
1177:is derived from equine sources using whole
14159:
14145:
13764:
13750:
12731:
12717:
12546:Tooltip Synaptosomal-associated protein 25
11025:
11011:
9656:
9642:
9009:
8995:
8597:Current Neurology and Neuroscience Reports
7857:
7713:Centers for Disease Control and Prevention
7577:Centers for Disease Control and Prevention
6913:"Medicare Guidelines for Botox Treatments"
6570:
5599:
5464:Centers for Disease Control and Prevention
5427:Centers for Disease Control and Prevention
5355:
5353:
4867:
4799:American Journal of Health-System Pharmacy
3748:
3746:
3744:
3742:
3583:"Botulinum toxin in poststroke spasticity"
3429:
3427:
3425:
3036:
512:
29:
13187:
10581:Androctonus australis hector insect toxin
8839:
8829:
8794:
8784:
8594:
8454:
8343:
8302:
8004:
7897:
7805:
7682:
7672:
7631:
7621:
7539:
7427:
7149:
6747:
6195:
6042:
5892:
5882:
5841:
5831:
5769:
5746:
5736:
5686:
5626:
5582:
5092:
5051:
5002:
4895:
4885:
4810:
4501:
4484:
4474:
4456:
4367:
4289:
4197:
4187:
3949:
3924:Villalba H, Villalba S, Abbas MA (2007).
3864:
3854:
3813:
3781:
3722:
3680:"Cervical dystonia - Symptoms and causes"
3655:
3606:
3522:
3481:
3374:
3318:
3308:
3273:
3257:. University of Minnesota. 17 June 2015.
3157:
3130:
1854:Learn how and when to remove this message
1521:Learn how and when to remove this message
1209:), toxins acting inside the axon terminal
943:
461:
453:
8222:. Allergan. 24 June 2011. Archived from
6987:The American Academy of Facial Esthetics
6826:. American Society of Plastic Surgeons.
6253:
5703:
5547:
5445:
5367:(FDA). 13 September 2015. Archived from
5195:
5193:
5119:"How Barely-There Botox Became the Norm"
5115:
3881:
3794:Therapeutic Advances in Gastroenterology
2578:"Regulatory Decision Summary for Xeomin"
2237:
2177:Botulinum toxin type-A is used to treat
1616:
1192:
1026:
11650:Dimethyl 4-(methylthio)phenyl phosphate
8517:
8153:
7741:"Clostridium botulinum Toxin Formation"
7454:. Hugh Source (International) Limited.
6792:
6531:
6529:
6409:
6407:
6065:
6019:"AbobotulinumtoxinA: A 25-Year History"
5922:
5611:"Botulinum toxin: mechanisms of action"
5350:
4792:
4038:
3830:
3739:
3422:
3245:
3243:
3241:
3214:
3212:
2604:"Regulatory Decision Summary for Botox"
2548:"Regulatory Decision Summary - Nuceiva"
2222:List of investigational antidepressants
416:
408:
168:
14464:
8485:(FDA). 19 October 2010. Archived from
8471:
8121:(FDA). 29 October 2009. Archived from
7828:
7476:
7215:(FDA). 9 February 2009. Archived from
6493:
6491:
6377:
6373:
6371:
5411:from the original on 21 February 2009.
5297:(FDA). 8 February 2008. Archived from
5164:(FDA). 8 February 2008. Archived from
4642:from the original on 10 September 2022
4546:
4131:"FDA Approved Drug Products – Dysport"
4042:Botulinum Neurotoxin and Tetanus Toxin
3752:
3226:from the original on 14 September 2021
2933:from the original on 28 September 2022
2466:Therapeutic Goods Administration (TGA)
2436:Therapeutic Goods Administration (TGA)
2406:Therapeutic Goods Administration (TGA)
2351:Therapeutic Goods Administration (TGA)
1656:
1581:'s work with chicks at Johns Hopkins,
1377:Initial descriptions and discovery of
1188:
897:, post-spinal cord injury spasticity,
503:
352:
324:
14140:
14106:Pregnancy-associated plasma protein A
13745:
13186:
12712:
11840:Methylfluorophosphonylcholine (MFPCh)
11090:2-(α-Naphthoyl)ethyltrimethylammonium
11006:
9637:
8990:
8898:(Botulinum neurotoxin type B) at the
8877:(Botulinum neurotoxin type A) at the
8258:from the original on 12 November 2012
7604:Poulain B, Popoff MR (January 2019).
7514:Schantz EJ, Johnson EA (March 1992).
7410:Walker TJ, Dayan SH (February 2014).
7385:from the original on 15 November 2012
7339:from the original on 23 November 2019
7279:from the original on 18 December 2022
7249:from the original on 24 November 2019
7096:from the original on 11 November 2021
7079:Essence of Anesthesia Practice E-Book
7022:. Cliggott Publishing. Archived from
6950:Highlights of Prescribing Information
6331:
5679:10.1146/annurev-biochem-013118-111654
5338:from the original on 18 December 2022
5190:
5150:
5138:from the original on 28 December 2021
5075:Hamman MS, Goldman MP (August 2013).
4542:
4540:
4516:
4438:from the original on 16 February 2024
4328:from the original on 28 November 2014
4311:
4309:
4076:
4074:
4003:
3704:
3686:from the original on 12 December 2018
3539:
3410:from the original on 6 September 2015
2829:from the original on 18 December 2022
2766:from the original on 18 December 2022
2736:from the original on 18 December 2022
2706:from the original on 18 December 2022
2676:from the original on 18 December 2022
2518:"Regulatory Decision Summary - Botox"
2324:from the original on 18 December 2022
2037:Botulinum toxin therapy of strabismus
1338:. Nonclassical types include BoNT/X (
1330:and the light chain is classified by
981:
337:
186:
151:
143:
135:
127:
119:
111:
8691:from the original on 30 October 2017
7761:from the original on 8 February 2021
7177:Encyclopedia of Bioterrorism Defense
7128:from the original on 23 October 2020
7057:from the original on 24 January 2022
7012:Koirala J, Basnet S (14 July 2004).
6845:
6646:Otolaryngology–Head and Neck Surgery
6526:
6424:(FDA). 30 April 2009. Archived from
6404:
6392:from the original on 26 January 2011
5500:from the original on 1 November 2023
5490:"Botulism - Diagnosis and treatment"
5460:"Botulism – Diagnosis and Treatment"
5267:(FDA). 3 August 2009. Archived from
5237:(FDA). 3 August 2009. Archived from
4606:from the original on 1 February 2024
4316:Ocampo VV, Foster CS (30 May 2012).
4220:
4141:from the original on 8 November 2016
3581:Ozcakir S, Sivrioglu K (June 2007).
3261:from the original on 28 October 2019
3238:
3209:
2172:
1957:
1802:
1704:American Society of Plastic Surgeons
1665:
1503:adding citations to reliable sources
1474:
1323:. The two are collectively known as
884:
268:
12637:
11140:N,N-Dimethylaminoethylchloroacetate
8964:"PrabotulinumtoxinA-xvfs Injection"
8238:
8212:
8107:
8064:
7275:(Press release). 24 November 2022.
6488:
6368:
6298:
5663:"Botulinum and Tetanus Neurotoxins"
5470:from the original on 5 October 2016
5433:from the original on 5 October 2016
4059:from the original on 28 August 2021
2188:
1954:Organism and toxin susceptibilities
1894:
490:
482:
13:
9935:Staphylococcal Enterotoxin B (SEB)
8773:Plastic and Reconstructive Surgery
8760:
8640:Plastic and Reconstructive Surgery
7721:from the original on 3 August 2016
7585:from the original on 27 April 2020
6963:from the original on 28 March 2021
6893:from the original on 13 March 2023
6623:10.1111/j.1524-4725.1992.tb03295.x
6585:10.1016/j.clindermatol.2003.11.003
6550:10.1097/01.prs.0000082208.37239.5b
6538:Plastic and Reconstructive Surgery
6512:10.1097/01.prs.0000205566.47797.8d
6500:Plastic and Reconstructive Surgery
6108:from the original on 2 August 2022
6017:Monheit GD, Pickett A (May 2017).
5521:The Journal of Infectious Diseases
5032:Postepy Dermatologii I Alergologii
4983:Postepy Dermatologii I Alergologii
4731:from the original on 30 April 2024
4687:from the original on 23 March 2024
4559:from the original on 18 March 2021
4537:
4306:
4071:
3711:Plastic and Reconstructive Surgery
3511:Indian Journal of Medical Research
3445:from the original on 23 March 2019
3096:Plastic and Reconstructive Surgery
2498:from the original on 31 March 2024
2472:from the original on 10 April 2023
2412:from the original on 18 March 2023
2076:Plastic and Reconstructive Surgery
1628:Plastic and Reconstructive Surgery
1131:
14:
14533:
11074:Tooltip Choline acetyltransferase
8857:
8532:from the original on 27 July 2020
8200:from the original on 21 July 2021
7458:from the original on 24 July 2008
7309:from the original on 27 July 2020
6863:from the original on 27 June 2021
6833:from the original on 23 June 2021
4111:from the original on 27 July 2020
2646:from the original on 7 April 2024
2614:from the original on 2 April 2024
2528:from the original on 12 June 2022
2442:from the original on 8 April 2023
2402:"Nuceiva (PPD Australia Pty Ltd)"
295:
218:
14477:Acetylcholine release inhibitors
14449:
14437:
13713:
13712:
12134:Fasciculins (green mamba toxins)
11625:Dicyclohexyl phosphorofluoridate
10987:
10986:
8738:
8724:10.1016/j.jpsychires.2013.11.006
8703:
8631:
8588:
8566:10.1111/j.1526-4610.2010.01678.x
8544:
8511:
8499:
8430:
8182:
8147:
8135:
8030:Journal Français d'Ophtalmologie
8021:
7972:
7941:
7914:
7822:
7773:
7733:
7699:
7648:
7597:
7507:
7470:
7444:
7361:
7349:
7329:"Drug Approval Package: Jeuveau"
7321:
7291:
7261:
7231:
7201:
7168:
7143:
7108:
7069:
7038:
7005:
6993:from the original on 22 May 2021
6975:
6935:
6923:from the original on 23 May 2021
6905:
6875:
6813:
6786:
6764:
6715:
6680:
6637:
6441:
6415:"Re: Docket No. FDA-2008-P-0061"
6325:
6247:
6212:
6163:
6120:
5381:
5211:from the original on 6 July 2019
5178:
4958:from the original on 23 May 2022
4697:
4616:
4151:
3856:10.1111/j.1875-595X.2011.00085.x
3707:"Botox treatment for vaginismus"
3682:. Mayo Clinic. 28 January 2014.
3587:Clinical Medicine & Research
3187:10.1111/j.1468-1331.2006.01438.x
3050:Critical Reviews in Microbiology
3014:10.2165/00003495-200262040-00011
2894:from the original on 2 June 2022
2864:from the original on 2 June 2022
2799:from the original on 2 June 2022
2558:from the original on 7 June 2022
1962:
1807:
1739:
1670:
1479:
1467:, which she designated A and B.
1022:
543:
537:
12065:Tetraethyl pyrophosphate (TEPP)
11790:Hexaethyl tetraphosphate (HETP)
10019:Extracellular adenylate cyclase
8976:"RimabotulinumtoxinB Injection"
8940:"IncobotulinumtoxinA Injection"
8712:Journal of Psychiatric Research
7185:10.1002/0471686786.ebd0012.pub2
6778:. 11 March 2019. Archived from
6728:British Journal of Pharmacology
6474:10.1016/j.healthpol.2009.12.001
6094:
6068:Current Opinion in Microbiology
6059:
5858:
5512:
5482:
5415:
5393:
5283:
5253:
5223:
5109:
5068:
5019:
4970:
4827:
4786:
4743:
4717:"Novel Drug Approvals for 2024"
4709:
4673:"Drug Trials Snapshots: Letybo"
4628:
4592:"Drug Trials Snapshot: Daxxify"
4450:
4414:
4402:from the original on 5 May 2017
4384:
4257:
4214:
4163:
4123:
4093:
4032:
3997:
3966:
3917:
3698:
3672:
3623:
3574:
3498:
3457:
3391:
2993:
2967:Current Opinion in Pharmacology
2876:
2811:
2748:
2718:
2688:
2658:
2626:
2608:Drug and Health Products Portal
2596:
2582:Drug and Health Products Portal
2570:
2540:
1756:
1640:
1540:
1490:needs additional citations for
1470:
1362:) found in the rice-colonizing
1183:heptavalent botulinum antitoxin
1095:
1002:botulinum toxin injections for
876:
834:. The toxin causes the disease
74:Botox, Myobloc, Jeuveau, others
11135:N,N-Dimethylaminoethylacrylate
8952:"OnabotulinumtoxinA Injection"
8928:"AbobotulinumtoxinA Injection"
7754:. 29 March 2011. p. 246.
6188:10.1113/jphysiol.1949.sp004364
4844:10.1002/14651858.cd008271.pub2
4457:Satriyasa BK (10 April 2019).
3983:10.1002/14651858.CD005493.pub3
3367:10.1002/14651858.CD001408.pub2
2510:
2484:
2454:
2424:
2394:
2248:The drug for the treatment of
1798:
1451:, as it was decided that term
1217:that use the neurotransmitter
555:
549:
531:
308:
1:
12738:
12688:Receptor/signaling modulators
12460:Hemicholinium-3 (hemicholine)
12359:Tooltip Butyrylcholinesterase
10171:Fibronectin binding protein A
8518:Watkins T (15 October 2010).
7958:10.1016/s0161-6420(89)32989-7
7890:10.1016/j.toxicon.2009.03.016
7798:10.1128/AEM.15.2.249-256.1967
7369:"2011 Allergan Annual Report"
6887:American Cosmetic Association
6378:Boffey PM (14 October 1986).
6346:10.1016/s0161-6420(80)35127-0
6233:10.1016/s0161-6420(82)34764-8
5667:Annual Review of Biochemistry
5615:Arquivos de Neuro-Psiquiatria
4874:Indian Journal of Dermatology
4090:. dddmag.com. 4 February 2014
4039:Simpson L (2 December 2012).
4018:10.3928/0191-3913-19940301-05
3175:European Journal of Neurology
2259:
2215:
2157:
2068:
2058:in people over 12 years old.
1942:spores, where exposure to an
1721:
1560:
14512:Peripherally selective drugs
14111:Bone morphogenetic protein 1
11155:Tooltip Acetylcholinesterase
8786:10.1097/PRS.0000000000006327
8652:10.1097/PRS.0000000000001733
8483:Food and Drug Administration
8295:10.7860/JCDR/2014/11624.5341
8119:Food and Drug Administration
7750:Food and Drug Administration
7532:10.1128/MMBR.56.1.80-99.1992
7486:The European Aesthetic Guide
7333:Food and Drug Administration
7303:Food and Drug Administration
7243:Food and Drug Administration
7213:Food and Drug Administration
7179:. Wiley-Liss. pp. 1–2.
7082:. Elsevier Health Sciences.
6954:Food and Drug Administration
6422:Food and Drug Administration
6276:10.1126/science.145.3633.719
6149:10.1126/science.103.2681.613
5563:Emerging Infectious Diseases
5365:Food and Drug Administration
5332:Food and Drug Administration
5295:Food and Drug Administration
5265:Food and Drug Administration
5235:Food and Drug Administration
5162:Food and Drug Administration
4793:Charles PD (November 2004).
4723:Food and Drug Administration
4679:Food and Drug Administration
4598:Food and Drug Administration
4282:10.1016/j.mayocp.2012.04.017
4135:Food and Drug Administration
3903:10.1016/j.eururo.2011.07.001
3843:International Dental Journal
3724:10.1097/PRS.0b013e3181bf7f11
3108:10.1097/PRS.0000000000007762
2089:Food and Drug Administration
2061:In the case of treatment of
2031:Blepharospasm and strabismus
1730:
1713:
1661:
1612:
1142:Botulinum toxin produced by
963:Food and Drug Administration
436:Botulinum toxin A: none
7:
14166:
12957:Hair coloring and bleaching
12449:Tooltip Choline transporter
12395:Profenamine (ethopropazine)
11635:Diisopropyl fluorophosphate
11100:4-(1-Naphthylvinyl)pyridine
11085:1-(-Benzoylethyl)pyridinium
9912:Staphylococcus aureus alpha
9890:Panton–Valentine leukocidin
6307:Investigative Ophthalmology
6102:"Home Canning and Botulism"
5780:10.1007/978-3-642-33570-9_1
5116:Schiffer J (8 April 2021).
4812:10.1093/ajhp/61.suppl_6.S11
2230:. Research is based on the
2122:Upper motor neuron syndrome
2025:
1830:, discuss the issue on the
1747:
1635:Vancouver, British Columbia
993:
873:ng/kg when taken by mouth.
869:ng/kg when inhaled, or 1000
10:
14538:
12298:Dimethylcarbamoyl fluoride
11105:Acetylseco hemicholinium-3
9930:Toxic shock syndrome toxin
8831:10.1007/s40265-021-01631-w
8416:10.1016/j.jaad.2010.02.053
6883:"How Much Does Botox Cost"
4944:10.1016/j.jaad.2005.06.011
4868:Nigam PK, Nigam A (2010).
4650:– via Business Wire.
3705:Pacik PT (December 2009).
3159:10.1016/j.jdds.2014.06.002
2979:10.1016/j.coph.2004.12.006
2241:
2232:facial feedback hypothesis
2219:
2192:
2034:
2018:, e.g., zinc-coordinating
1371:
1181:. The second antitoxin is
1135:
998:In 2010, the FDA approved
850:of type A toxin is 1.3–2.1
521:Chemical and physical data
14472:Drugs developed by AbbVie
14323:
14315:Michaelis–Menten kinetics
14287:
14256:
14225:
14174:
14083:
13938:Matrix metalloproteinases
13936:
13791:
13708:
13193:
13182:
13131:
13090:
13054:
12944:
12893:
12857:
12746:
12680:
12626:
12530:
12513:
12483:
12442:
12425:
12352:
11148:
11067:
11050:
10982:
10969:
10907:
10827:(+)-Allopumiliotoxin 267A
10814:
10788:
10777:
10732:
10674:
10568:
10557:
10326:
10183:
10154:
10090:
10027:
9974:
9947:
9900:
9875:
9866:
9839:
9752:
9743:
9723:
9712:
9613:
9468:
9439:
9421:
9403:
9385:
9332:
9278:
9269:
9247:
9236:Polyalkylene derivatives:
9212:
9090:
9050:
9030:
8609:10.1007/s11910-010-0087-5
8381:10.1016/j.pio.2010.04.004
8042:10.1016/j.jfo.2020.07.023
7843:10.1016/j.tim.2007.02.004
7305:(FDA). 24 December 1999.
6857:Fortune Business Insights
6793:Chapman L (10 May 2012).
6176:The Journal of Physiology
6080:10.1016/j.mib.2012.05.005
6023:Aesthetic Surgery Journal
5738:10.3390/molecules16010202
4547:Krause R (10 June 2019).
4519:American Family Physician
4235:10.1007/s40272-017-0242-4
4176:Frontiers in Pharmacology
4081:UK Approves New Botox Use
3439:World Health Organization
3310:10.2106/JBJS.RVW.19.00119
3062:10.1080/10408410590912952
2130:syndrome (UMNS), such as
1679:This article needs to be
770:
758:
746:
741:
737:
721:
702:
690:
678:
666:
654:
642:
630:
625:
613:
608:
603:
581:
564:
525:
520:
501:
472:
443:
427:
398:
369:
364:
285:
280:
254:
232:
206:
176:
162:
97:
86:
78:
68:
63:
38:of tertiary structure of
28:
14207:Diffusion-limited enzyme
14121:Insulin-degrading enzyme
12168:Methanesulfonyl fluoride
10220:beta-Nitropropionic acid
8919:(Bontoxilysin A) at the
8456:10.1001/archoto.2010.240
8369:Progress in Orthodontics
7997:10.1177/1756285614557475
7477:Petrou I (Spring 2009).
7452:"Botulinum Toxin Type A"
7287:– via PR Newswire.
6853:"Botulinum Toxin Market"
5334:(FDA). 3 November 2018.
4189:10.3389/fphar.2016.00029
4086:22 February 2014 at the
3806:10.1177/1756283X12468039
3435:"Fact sheets - Botulism"
2108:levator labii superioris
1933:horizontally transferred
1071:
1043:, Dysport/Azzalure from
489:Botulinum toxin B:
481:Botulinum toxin A:
460:Botulinum toxin B:
452:Botulinum toxin A:
415:Botulinum toxin B:
407:Botulinum toxin A:
386:Botulinum toxin B:
378:Botulinum toxin A:
263:Botulinum toxin A:
13431:Laura Mercier Cosmetics
13213:Anastasia Beverly Hills
13139:Cosmetic electrotherapy
12764:Botulinum toxin (Botox)
11345:+glycopyrronium bromide
10004:Heat-labile enterotoxin
9995:heat-stable enterotoxin
7520:Microbiological Reviews
7245:(FDA). 17 August 2011.
6658:10.1067/mhn.2000.110960
5931:(Supplement 8): S2–S6.
5884:10.1002/1873-3468.12969
4887:10.4103/0019-5154.60343
4805:(22 Suppl 6): S11–S23.
4356:Mayo Clinic Proceedings
4270:Mayo Clinic Proceedings
3636:Medical Science Monitor
3560:10.1001/jama.285.8.1059
3483:10.1002/1873-3468.13446
2002:The botulinum toxin is
1607:1983 US Orphan Drug Act
1311:and closely related to
1160:Guillain–Barré syndrome
13396:Jeffree Star Cosmetics
13323:Daigaku Honyaku Center
11095:3-Chloro-4-stillbazole
10113:Bacillus thuringiensis
9249:ACh release inhibitors
9131:intermediate duration:
8744:Clinical trial number
8646:(5 Suppl): 111S–119S.
8481:(Press release). U.S.
8332:The Angle Orthodontist
8085:10.1055/s-2008-1064563
8073:Facial Plastic Surgery
7831:Trends in Microbiology
7674:10.1186/1741-7007-7-66
7623:10.3390/toxins11010034
6573:Clinics in Dermatology
6544:(5 Suppl): 177S–188S.
5833:10.3390/toxins10100421
5575:10.3201/eid1110.041279
5233:(Press release). U.S.
5044:10.5114/ada.2019.82795
4995:10.5114/ada.2019.82795
4764:10.1055/s-0036-1571953
3930:The Permanente Journal
2212:headache medications.
1622:
1411:
1210:
1032:
944:Other muscle disorders
901:of the head and neck,
828:neuromuscular junction
799:), is a highly potent
14300:Eadie–Hofstee diagram
14233:Allosteric regulation
14096:Procollagen peptidase
13777:metalloendopeptidases
13338:Elizabeth Arden, Inc.
13243:Bath & Body Works
13188:Major cosmetic brands
13149:Cosmetics advertising
9100:ultra-short duration:
7335:(FDA). 5 March 2019.
7049:Clostridium botulinum
6919:. 27 September 2021.
6701:10.1001/jama.2012.505
5983:10.1212/wnl.53.8.1850
5772:Botulinum Neurotoxins
5533:10.1093/infdis/jit449
5205:Pharmaceutical Online
4752:Seminars in Neurology
2929:. 19 September 2022.
2250:premature ejaculation
2238:Premature ejaculation
2144:reciprocal inhibition
1944:anaerobic environment
1792:Clostridium botulinum
1620:
1465:Clostridium botulinum
1449:Clostridium botulinum
1424:Clostridium botulinum
1415:, meaning 'sausage'.
1379:Clostridium botulinum
1307:Botulinum toxins are
1229:by receptor-mediated
1196:
1144:Clostridium botulinum
1030:
961:In July 2016, the US
812:Clostridium botulinum
14310:Lineweaver–Burk plot
13526:Neal's Yard Remedies
13164:History of cosmetics
13144:Cosmetic ingredients
12656:Atracotoxins (e.g.,
12283:Tetrahydrocannabinol
11630:Diisopropylphosphate
10014:Pseudomonas exotoxin
9476:Arbaclofen placarbil
9169:Dimethyltubocurarine
9077:Dimethyltubocurarine
8345:10.2319/091407-437.1
8156:Journal of Marketing
7786:Applied Microbiology
5371:on 13 September 2015
5241:on 24 September 2015
4683:. 29 February 2024.
4602:. 7 September 2022.
4476:10.2147/CCID.S202919
3599:10.3121/cmr.2007.716
2890:. 28 February 2022.
2408:. 16 February 2023.
1922:C. argentinense
1836:create a new article
1828:improve this article
1535:Karl Friedrich Meyer
1499:improve this article
1319:, and in particular
1153:floppy baby syndrome
793:botulinum neurotoxin
150:rimabotulinumtoxinB
126:incobotulinumtoxinA
118:daxibotulinumtoxinA
13303:ColourPop Cosmetics
12906:Circle contact lens
12642:Tooltip Latrophilin
12344:Trimedoxime bromide
12273:Stercuronium iodide
12090:Tricresyl phosphate
11565:Chlorpyrifos-methyl
9223:Choline derivatives
9032:Peripherally acting
8251:The Washington Post
8196:. 22 January 2014.
7882:2009Txcn...54..575C
6268:1964Sci...145..719D
6141:1946Sci...103..613L
6029:(suppl_1): S4–S11.
5423:"Kinds of Botulism"
5407:. 13 January 2009.
3648:10.12659/MSM.911296
3441:. 10 January 2018.
2825:. 9 February 2021.
2610:. 7 February 2024.
2554:. 23 October 2014.
2524:. 23 October 2014.
2438:. 26 January 2023.
2063:infantile esotropia
2016:protease inhibitors
1657:Society and culture
1189:Mechanism of action
976:infantile esotropia
923:lower urinary tract
333:(Prescription only)
304:(Prescription only)
142:prabotulinumtoxinA
134:onabotulinumtoxinA
110:abobotulinumtoxinA
93:rimabotulinumtoxinB
25:
14269:Enzyme superfamily
14202:Enzyme promiscuity
13154:Cosmetic packaging
12911:Eyelash extensions
12161:Onchidella binneyi
11503:Organophosphates:
10930:Alpha-Bungarotoxin
10100:Lipopolysaccharide
10058:Pore-forming toxin
9387:Nonbenzodiazepines
9092:4° ammonium agents
8752:ClinicalTrials.gov
8489:on 19 October 2010
8168:10.1509/jm.10.0406
7717:. 19 August 2019.
7581:. 9 October 2018.
7219:on 13 January 2017
7150:Baselt RC (2014).
6385:The New York Times
6035:10.1093/asj/sjw284
5925:Movement Disorders
5124:The New York Times
4429:Accessdata.fda.gov
3942:10.7812/tpp/07-072
2702:. 2 October 2022.
2672:. 16 August 2022.
2353:. 10 February 2023
2128:upper motor neuron
1623:
1579:Daniel B. Drachman
1575:strabismus surgery
1445:Bacillus botulinus
1441:Bacillus botulinus
1433:Bacillus botulinus
1420:Émile van Ermengem
1264:composed of a 100-
1211:
1203:tetanus neurotoxin
1106:trouble swallowing
1033:
982:Excessive sweating
938:overactive bladder
909:, limbs, jaw, and
848:median lethal dose
21:
14425:
14424:
14134:
14133:
13739:
13738:
13704:
13703:
13681:Victoria's Secret
13391:Helena Rubinstein
13273:Bumble and bumble
13169:Cosmetic industry
12706:
12705:
12676:
12675:
12524:
12509:
12508:
12436:
12421:
12420:
12060:Tetrachlorvinphos
11935:Pirimiphos-methyl
11885:Oxydemeton-methyl
11835:Methyl phenkapton
11061:
11000:
10999:
10965:
10964:
10935:Beta-Bungarotoxin
10879:Pumiliotoxin 251D
10773:
10772:
10179:
10178:
10166:Clumping factor A
10086:
10085:
9970:
9969:
9943:
9942:
9862:
9861:
9631:
9630:
9609:
9608:
9265:
9264:
9230:(Succinylcholine)
9208:
9207:
8824:(18): 2091–2101.
8289:(12): ZE25–ZE29.
8254:. 12 April 2008.
7194:978-0-471-68678-1
7161:978-0-9626523-9-4
7089:978-0-323-39541-0
6782:on 12 March 2019.
6740:10.1111/bph.12763
6734:(18): 4177–4192.
6695:(16): 1736–1745.
6340:(10): 1044–1049.
6262:(3633): 719–721.
6135:(2681): 613–614.
5937:10.1002/mds.20003
5789:978-3-642-33569-3
5628:10.1159/000083259
5569:(10): 1578–1583.
5207:. 4 August 2009.
4870:"Botulinum toxin"
4727:. 29 April 2024.
4105:The Pharma Letter
4052:978-0-323-14160-4
3476:(12): 1403–1410.
3181:(Suppl 1): 2–10.
2860:. 22 March 2021.
2642:. 14 March 2017.
2179:cervical dystonia
2173:Cervical dystonia
2116:zygomaticus minor
2114:(LLSAN), and the
1997:C. botulinum
1993:
1992:
1929:C. botulinum
1910:C. butyricum
1905:C. botulinum
1864:
1863:
1856:
1838:, as appropriate.
1700:
1699:
1646:William J. Binder
1531:
1530:
1523:
1390:Baden-Württemberg
1356:; and a BoNT/Wo (
1255:flaccid paralysis
1225:the toxin into a
1164:myasthenia gravis
1148:C. botulinum
885:Muscle spasticity
832:flaccid paralysis
795:(commonly called
786:
785:
782:
781:
685:metabolic pathway
599:
598:
356:
341:
328:
311:
299:
222:
189:
23:Botulinum toxin A
14529:
14502:Muscle relaxants
14482:Bacterial toxins
14454:
14453:
14452:
14442:
14441:
14433:
14305:Hanes–Woolf plot
14248:Enzyme activator
14243:Enzyme inhibitor
14217:Enzyme catalysis
14161:
14154:
14147:
14138:
14137:
13801:Alpha secretases
13766:
13759:
13752:
13743:
13742:
13716:
13715:
13501:Morphe Cosmetics
13466:Make Up For Ever
13283:Carol's Daughter
13184:
13183:
13062:Artificial nails
13019:Styling products
12824:Permanent makeup
12754:Anti-aging cream
12733:
12726:
12719:
12710:
12709:
12643:
12639:
12578:
12574:
12547:
12543:
12528:
12527:
12518:
12491:
12487:
12450:
12446:
12440:
12439:
12430:
12360:
12356:
12324:Asoxime chloride
11900:Parathion-methyl
11600:Demeton-S-methyl
11156:
11152:
11075:
11071:
11065:
11064:
11055:
11027:
11020:
11013:
11004:
11003:
10990:
10989:
10918:
10874:Histrionicotoxin
10820:
10794:
10786:
10785:
10738:
10692:Alpha-latrotoxin
10680:
10574:
10566:
10565:
10298:Sterigmatocystin
10250:, Fumonisin B3,
10214:epsilon-amanitin
10133:B. thuringiensis
9962:Diphtheria toxin
9905:
9873:
9872:
9842:
9758:
9750:
9749:
9741:
9740:
9730:
9729:
9721:
9720:
9658:
9651:
9644:
9635:
9634:
9586:Thiocolchicoside
9441:Anticholinergics
9405:Thienodiazepines
9276:
9275:
9271:Centrally acting
9201:(Hexafluorenium)
9057:
9056:
9052:Non-depolarizing
9048:
9047:
9019:muscle relaxants
9011:
9004:
8997:
8988:
8987:
8983:
8971:
8959:
8947:
8935:
8853:
8843:
8833:
8808:
8798:
8788:
8754:
8742:
8736:
8735:
8707:
8701:
8700:
8698:
8696:
8681:
8672:
8671:
8635:
8629:
8628:
8592:
8586:
8585:
8548:
8542:
8541:
8539:
8537:
8515:
8509:
8503:
8502:
8498:
8496:
8494:
8475:
8469:
8468:
8458:
8434:
8428:
8427:
8410:(6): 1042–1051.
8399:
8393:
8392:
8364:
8358:
8357:
8347:
8323:
8317:
8316:
8306:
8274:
8268:
8267:
8265:
8263:
8242:
8236:
8235:
8233:
8231:
8216:
8210:
8209:
8207:
8205:
8186:
8180:
8179:
8151:
8145:
8139:
8138:
8134:
8132:
8130:
8111:
8105:
8104:
8068:
8062:
8061:
8025:
8019:
8018:
8008:
7976:
7970:
7969:
7945:
7939:
7938:
7918:
7912:
7911:
7901:
7861:
7855:
7854:
7826:
7820:
7819:
7809:
7777:
7771:
7770:
7768:
7766:
7760:
7745:
7737:
7731:
7730:
7728:
7726:
7703:
7697:
7696:
7686:
7676:
7652:
7646:
7645:
7635:
7625:
7601:
7595:
7594:
7592:
7590:
7571:"About Botulism"
7567:
7554:
7553:
7543:
7511:
7505:
7504:
7502:
7500:
7495:on 20 March 2013
7494:
7488:. Archived from
7483:
7474:
7468:
7467:
7465:
7463:
7448:
7442:
7441:
7431:
7407:
7396:
7394:
7392:
7390:
7384:
7373:
7365:
7359:
7353:
7352:
7348:
7346:
7344:
7325:
7319:
7318:
7316:
7314:
7295:
7289:
7288:
7286:
7284:
7265:
7259:
7258:
7256:
7254:
7235:
7229:
7228:
7226:
7224:
7205:
7199:
7198:
7172:
7166:
7165:
7147:
7141:
7140:
7135:
7133:
7127:
7120:
7112:
7106:
7105:
7103:
7101:
7073:
7067:
7066:
7064:
7062:
7042:
7036:
7035:
7033:
7031:
7009:
7003:
7002:
7000:
6998:
6979:
6973:
6972:
6970:
6968:
6962:
6947:
6939:
6933:
6932:
6930:
6928:
6909:
6903:
6902:
6900:
6898:
6879:
6873:
6872:
6870:
6868:
6849:
6843:
6842:
6840:
6838:
6832:
6825:
6817:
6811:
6810:
6808:
6806:
6801:on 6 August 2012
6797:. Archived from
6790:
6784:
6783:
6768:
6762:
6761:
6751:
6719:
6713:
6712:
6684:
6678:
6677:
6641:
6635:
6634:
6606:
6597:
6596:
6568:
6562:
6561:
6533:
6524:
6523:
6495:
6486:
6485:
6468:(2–3): 216–228.
6457:
6451:
6445:
6444:
6440:
6438:
6436:
6430:
6419:
6411:
6402:
6401:
6399:
6397:
6375:
6366:
6365:
6329:
6323:
6322:
6302:
6296:
6295:
6251:
6245:
6244:
6216:
6210:
6209:
6199:
6167:
6161:
6160:
6124:
6118:
6117:
6115:
6113:
6104:. 24 June 2022.
6098:
6092:
6091:
6063:
6057:
6056:
6046:
6014:
6003:
6002:
5977:(8): 1850–1853.
5966:
5957:
5956:
5920:
5907:
5906:
5896:
5886:
5862:
5856:
5855:
5845:
5835:
5811:
5802:
5801:
5767:
5761:
5760:
5750:
5740:
5716:
5701:
5700:
5690:
5658:
5649:
5648:
5630:
5606:
5597:
5596:
5586:
5554:
5545:
5544:
5516:
5510:
5509:
5507:
5505:
5486:
5480:
5479:
5477:
5475:
5456:
5443:
5442:
5440:
5438:
5419:
5413:
5412:
5397:
5391:
5385:
5384:
5380:
5378:
5376:
5357:
5348:
5347:
5345:
5343:
5324:
5311:
5310:
5308:
5306:
5287:
5281:
5280:
5278:
5276:
5257:
5251:
5250:
5248:
5246:
5227:
5221:
5220:
5218:
5216:
5197:
5188:
5182:
5181:
5177:
5175:
5173:
5154:
5148:
5147:
5145:
5143:
5121:
5113:
5107:
5106:
5096:
5072:
5066:
5065:
5055:
5023:
5017:
5016:
5006:
4974:
4968:
4967:
4965:
4963:
4923:
4910:
4909:
4899:
4889:
4865:
4856:
4855:
4831:
4825:
4824:
4814:
4790:
4784:
4783:
4747:
4741:
4740:
4738:
4736:
4713:
4707:
4701:
4700:
4696:
4694:
4692:
4669:
4652:
4651:
4649:
4647:
4632:
4626:
4620:
4619:
4615:
4613:
4611:
4588:
4569:
4568:
4566:
4564:
4544:
4535:
4534:
4514:
4499:
4498:
4488:
4478:
4454:
4448:
4447:
4445:
4443:
4437:
4426:
4418:
4412:
4411:
4409:
4407:
4388:
4382:
4381:
4371:
4369:10.4065/80.5.657
4347:
4338:
4337:
4335:
4333:
4313:
4304:
4303:
4293:
4261:
4255:
4254:
4223:Paediatric Drugs
4218:
4212:
4211:
4201:
4191:
4167:
4161:
4155:
4154:
4150:
4148:
4146:
4127:
4121:
4120:
4118:
4116:
4097:
4091:
4078:
4069:
4068:
4066:
4064:
4036:
4030:
4029:
4001:
3995:
3994:
3977:(12): CD005493.
3970:
3964:
3963:
3953:
3921:
3915:
3914:
3891:European Urology
3885:
3879:
3878:
3868:
3858:
3834:
3828:
3827:
3817:
3785:
3779:
3778:
3750:
3737:
3736:
3726:
3717:(6): 455e–456e.
3702:
3696:
3695:
3693:
3691:
3676:
3670:
3669:
3659:
3627:
3621:
3620:
3610:
3578:
3572:
3571:
3554:(8): 1059–1070.
3543:
3537:
3536:
3526:
3502:
3496:
3495:
3485:
3461:
3455:
3454:
3452:
3450:
3431:
3420:
3419:
3417:
3415:
3395:
3389:
3388:
3378:
3361:(10): CD001408.
3346:
3333:
3332:
3322:
3312:
3288:
3271:
3270:
3268:
3266:
3247:
3236:
3235:
3233:
3231:
3216:
3207:
3206:
3170:
3164:
3163:
3161:
3137:
3128:
3127:
3102:(4): 644e–657e.
3091:
3082:
3081:
3045:
3034:
3033:
2997:
2991:
2990:
2962:
2943:
2942:
2940:
2938:
2919:
2904:
2903:
2901:
2899:
2880:
2874:
2873:
2871:
2869:
2850:
2839:
2838:
2836:
2834:
2815:
2809:
2808:
2806:
2804:
2795:. 30 July 2021.
2785:
2776:
2775:
2773:
2771:
2762:. 28 July 2022.
2752:
2746:
2745:
2743:
2741:
2722:
2716:
2715:
2713:
2711:
2692:
2686:
2685:
2683:
2681:
2662:
2656:
2655:
2653:
2651:
2630:
2624:
2623:
2621:
2619:
2600:
2594:
2593:
2591:
2589:
2574:
2568:
2567:
2565:
2563:
2544:
2538:
2537:
2535:
2533:
2514:
2508:
2507:
2505:
2503:
2488:
2482:
2481:
2479:
2477:
2468:. 21 June 2022.
2458:
2452:
2451:
2449:
2447:
2428:
2422:
2421:
2419:
2417:
2398:
2392:
2391:
2389:
2387:
2377:nctr-crs.fda.gov
2369:
2363:
2362:
2360:
2358:
2343:
2334:
2333:
2331:
2329:
2314:
2303:
2302:
2300:
2298:
2283:
2189:Chronic migraine
2056:hemifacial spasm
1988:
1985:
1966:
1958:
1895:Toxin production
1879:manufactured by
1859:
1852:
1848:
1845:
1839:
1811:
1810:
1803:
1695:
1692:
1686:
1674:
1673:
1666:
1526:
1519:
1515:
1512:
1506:
1483:
1475:
1414:
1365:Weissella oryzae
1361:
1349:
1343:
1317:Diphtheria toxin
1294:neurotransmitter
1078:neuropathic pain
872:
868:
853:
817:neurotransmitter
806:produced by the
739:
738:
601:
600:
595:
594:
587:
576:
574:
557:
551:
545:
539:
533:
516:
505:
494:
486:
465:
457:
420:
412:
391:
383:
354:
351:
346:
339:
336:
326:
323:
319:
310:
307:
297:
294:
272:
220:
217:
199:
188:
185:
172:
155:
147:
139:
131:
123:
115:
57:
47:
33:
26:
24:
20:
14537:
14536:
14532:
14531:
14530:
14528:
14527:
14526:
14522:Protein domains
14517:Plastic surgery
14462:
14461:
14460:
14450:
14448:
14436:
14428:
14426:
14421:
14333:Oxidoreductases
14319:
14295:Enzyme kinetics
14283:
14279:List of enzymes
14252:
14221:
14192:Catalytic triad
14170:
14165:
14135:
14130:
14079:
13932:
13787:
13770:
13740:
13735:
13700:
13641:Tarte Cosmetics
13521:Nature Republic
13416:Kylie Cosmetics
13401:Kao Corporation
13189:
13178:
13127:
13123:Sunless tanning
13113:Plastic surgery
13086:
13050:
12940:
12889:
12853:
12849:Venetian ceruse
12814:Moist towelette
12742:
12737:
12707:
12702:
12672:
12641:
12622:
12582:Botulinum toxin
12576:
12551:Botulinum toxin
12545:
12517:
12505:
12489:
12479:
12465:Triethylcholine
12448:
12429:
12417:
12358:
12348:
12268:Rosmarinic acid
12035:Sulfotep (TEDP)
11705:Ethylsarin (GE)
11585:Cyclosarin (GF)
11555:Chlorfenvinphos
11545:Carbophenothion
11525:Azinphos-methyl
11154:
11144:
11110:Acryloylcholine
11073:
11054:
11046:
11031:
11001:
10996:
10978:
10961:
10957:Cardiotoxin III
10913:
10908:
10903:
10815:
10810:
10789:
10781:
10769:
10733:
10728:
10675:
10670:
10569:
10561:
10553:
10457:Resiniferatoxin
10322:
10175:
10157:
10150:
10115:delta endotoxin
10082:
10023:
10009:Pertussis toxin
9977:
9966:
9939:
9901:
9896:
9858:
9854:Listeriolysin O
9840:
9835:
9753:
9735:
9715:
9708:
9662:
9632:
9627:
9615:Directly acting
9605:
9464:
9455:Cyclobenzaprine
9446:Antimuscarinics
9443:
9435:
9417:
9399:
9381:
9334:Benzodiazepines
9328:
9261:
9257:Botulinum toxin
9243:
9204:
9086:
9040:
9034:
9026:
9015:
8974:
8962:
8950:
8938:
8926:
8860:
8763:
8761:Further reading
8758:
8757:
8743:
8739:
8708:
8704:
8694:
8692:
8683:
8682:
8675:
8636:
8632:
8593:
8589:
8549:
8545:
8535:
8533:
8516:
8512:
8500:
8492:
8490:
8477:
8476:
8472:
8435:
8431:
8400:
8396:
8365:
8361:
8324:
8320:
8275:
8271:
8261:
8259:
8244:
8243:
8239:
8229:
8227:
8226:on 26 June 2011
8218:
8217:
8213:
8203:
8201:
8188:
8187:
8183:
8152:
8148:
8136:
8128:
8126:
8125:on 8 March 2010
8113:
8112:
8108:
8069:
8065:
8026:
8022:
7977:
7973:
7947:
7946:
7942:
7919:
7915:
7862:
7858:
7827:
7823:
7778:
7774:
7764:
7762:
7758:
7743:
7739:
7738:
7734:
7724:
7722:
7705:
7704:
7700:
7653:
7649:
7602:
7598:
7588:
7586:
7569:
7568:
7557:
7512:
7508:
7498:
7496:
7492:
7481:
7475:
7471:
7461:
7459:
7450:
7449:
7445:
7408:
7399:
7388:
7386:
7382:
7371:
7367:
7366:
7362:
7350:
7342:
7340:
7327:
7326:
7322:
7312:
7310:
7297:
7296:
7292:
7282:
7280:
7267:
7266:
7262:
7252:
7250:
7237:
7236:
7232:
7222:
7220:
7207:
7206:
7202:
7195:
7173:
7169:
7162:
7148:
7144:
7131:
7129:
7125:
7118:
7114:
7113:
7109:
7099:
7097:
7090:
7074:
7070:
7060:
7058:
7043:
7039:
7029:
7027:
7010:
7006:
6996:
6994:
6981:
6980:
6976:
6966:
6964:
6960:
6945:
6941:
6940:
6936:
6926:
6924:
6917:MedicareFAQ.com
6911:
6910:
6906:
6896:
6894:
6881:
6880:
6876:
6866:
6864:
6851:
6850:
6846:
6836:
6834:
6830:
6823:
6819:
6818:
6814:
6804:
6802:
6791:
6787:
6776:Plastic Surgery
6770:
6769:
6765:
6720:
6716:
6685:
6681:
6642:
6638:
6607:
6600:
6569:
6565:
6534:
6527:
6496:
6489:
6458:
6454:
6442:
6434:
6432:
6428:
6417:
6413:
6412:
6405:
6395:
6393:
6376:
6369:
6330:
6326:
6313:(12): 924–927.
6303:
6299:
6252:
6248:
6217:
6213:
6168:
6164:
6125:
6121:
6111:
6109:
6100:
6099:
6095:
6064:
6060:
6015:
6006:
5967:
5960:
5921:
5910:
5863:
5859:
5812:
5805:
5790:
5768:
5764:
5717:
5704:
5659:
5652:
5607:
5600:
5555:
5548:
5517:
5513:
5503:
5501:
5488:
5487:
5483:
5473:
5471:
5458:
5457:
5446:
5436:
5434:
5421:
5420:
5416:
5399:
5398:
5394:
5382:
5374:
5372:
5359:
5358:
5351:
5341:
5339:
5326:
5325:
5314:
5304:
5302:
5289:
5288:
5284:
5274:
5272:
5259:
5258:
5254:
5244:
5242:
5229:
5228:
5224:
5214:
5212:
5199:
5198:
5191:
5179:
5171:
5169:
5168:on 2 March 2012
5156:
5155:
5151:
5141:
5139:
5114:
5110:
5073:
5069:
5024:
5020:
4975:
4971:
4961:
4959:
4924:
4913:
4866:
4859:
4838:(9): CD008271.
4832:
4828:
4791:
4787:
4748:
4744:
4734:
4732:
4715:
4714:
4710:
4698:
4690:
4688:
4671:
4670:
4655:
4645:
4643:
4634:
4633:
4629:
4617:
4609:
4607:
4590:
4589:
4572:
4562:
4560:
4545:
4538:
4515:
4502:
4455:
4451:
4441:
4439:
4435:
4424:
4420:
4419:
4415:
4405:
4403:
4390:
4389:
4385:
4348:
4341:
4331:
4329:
4314:
4307:
4276:(10): 982–990.
4262:
4258:
4219:
4215:
4168:
4164:
4152:
4144:
4142:
4129:
4128:
4124:
4114:
4112:
4099:
4098:
4094:
4088:Wayback Machine
4079:
4072:
4062:
4060:
4053:
4037:
4033:
4002:
3998:
3971:
3967:
3922:
3918:
3886:
3882:
3835:
3831:
3786:
3782:
3761:(10): 609–614.
3751:
3740:
3703:
3699:
3689:
3687:
3678:
3677:
3673:
3628:
3624:
3579:
3575:
3544:
3540:
3503:
3499:
3462:
3458:
3448:
3446:
3433:
3432:
3423:
3413:
3411:
3396:
3392:
3347:
3336:
3289:
3274:
3264:
3262:
3249:
3248:
3239:
3229:
3227:
3218:
3217:
3210:
3171:
3167:
3138:
3131:
3092:
3085:
3046:
3037:
2998:
2994:
2963:
2946:
2936:
2934:
2921:
2920:
2907:
2897:
2895:
2882:
2881:
2877:
2867:
2865:
2852:
2851:
2842:
2832:
2830:
2817:
2816:
2812:
2802:
2800:
2787:
2786:
2779:
2769:
2767:
2754:
2753:
2749:
2739:
2737:
2732:. 10 May 2022.
2724:
2723:
2719:
2709:
2707:
2694:
2693:
2689:
2679:
2677:
2664:
2663:
2659:
2649:
2647:
2632:
2631:
2627:
2617:
2615:
2602:
2601:
2597:
2587:
2585:
2584:. 15 March 2022
2576:
2575:
2571:
2561:
2559:
2546:
2545:
2541:
2531:
2529:
2516:
2515:
2511:
2501:
2499:
2490:
2489:
2485:
2475:
2473:
2460:
2459:
2455:
2445:
2443:
2430:
2429:
2425:
2415:
2413:
2400:
2399:
2395:
2385:
2383:
2371:
2370:
2366:
2356:
2354:
2345:
2344:
2337:
2327:
2325:
2316:
2315:
2306:
2296:
2294:
2293:. 5 August 2024
2285:
2284:
2267:
2262:
2246:
2240:
2224:
2218:
2197:
2191:
2175:
2160:
2124:
2071:
2039:
2033:
2028:
2008:metalloprotease
1989:
1983:
1980:
1973:needs expansion
1967:
1956:
1916:C. baratii
1897:
1860:
1849:
1843:
1840:
1825:
1812:
1808:
1801:
1781:
1759:
1750:
1742:
1733:
1724:
1716:
1696:
1690:
1687:
1684:
1675:
1671:
1664:
1659:
1643:
1615:
1563:
1543:
1527:
1516:
1510:
1507:
1496:
1484:
1473:
1402:Justinus Kerner
1388:in what is now
1382:
1374:
1357:
1350:) found in cow
1345:
1339:
1282:metalloprotease
1191:
1140:
1134:
1132:Role in disease
1098:
1074:
1025:
996:
984:
946:
887:
879:
870:
866:
863:intramuscularly
851:
830:, thus causing
826:endings at the
789:Botulinum toxin
590:
588:
585:(what is this?)
582:
572:
570:
560:
554:
548:
542:
536:
497:
468:
439:
423:
394:
360:
344:
317:
276:
235:
228:
209:
202:
197:Botulinum toxin
158:
59:
53:
43:
17:
12:
11:
5:
14535:
14525:
14524:
14519:
14514:
14509:
14504:
14499:
14494:
14489:
14487:Protein toxins
14484:
14479:
14474:
14459:
14458:
14446:
14423:
14422:
14420:
14419:
14406:
14393:
14380:
14367:
14354:
14341:
14327:
14325:
14321:
14320:
14318:
14317:
14312:
14307:
14302:
14297:
14291:
14289:
14285:
14284:
14282:
14281:
14276:
14271:
14266:
14260:
14258:
14257:Classification
14254:
14253:
14251:
14250:
14245:
14240:
14235:
14229:
14227:
14223:
14222:
14220:
14219:
14214:
14209:
14204:
14199:
14194:
14189:
14184:
14178:
14176:
14172:
14171:
14164:
14163:
14156:
14149:
14141:
14132:
14131:
14129:
14128:
14123:
14118:
14113:
14108:
14103:
14098:
14093:
14087:
14085:
14081:
14080:
14078:
14077:
14072:
14067:
14062:
14057:
14052:
14047:
14042:
14037:
14032:
14027:
14022:
14017:
14012:
14007:
14002:
13997:
13992:
13987:
13982:
13977:
13976:
13975:
13970:
13960:
13959:
13958:
13953:
13942:
13940:
13934:
13933:
13931:
13930:
13925:
13920:
13915:
13910:
13905:
13900:
13895:
13890:
13885:
13880:
13875:
13870:
13865:
13860:
13855:
13850:
13845:
13840:
13835:
13830:
13825:
13824:
13823:
13818:
13813:
13808:
13797:
13795:
13789:
13788:
13769:
13768:
13761:
13754:
13746:
13737:
13736:
13734:
13733:
13728:
13723:
13718:
13709:
13706:
13705:
13702:
13701:
13699:
13698:
13693:
13688:
13683:
13678:
13673:
13668:
13663:
13658:
13653:
13648:
13643:
13638:
13633:
13628:
13623:
13618:
13613:
13608:
13603:
13598:
13593:
13591:Richard Hudnut
13588:
13583:
13578:
13573:
13568:
13563:
13558:
13553:
13548:
13543:
13538:
13533:
13528:
13523:
13518:
13516:Natural Wonder
13513:
13508:
13503:
13498:
13493:
13488:
13483:
13478:
13473:
13468:
13463:
13458:
13453:
13451:Love Cosmetics
13448:
13443:
13438:
13433:
13428:
13423:
13418:
13413:
13408:
13403:
13398:
13393:
13388:
13383:
13378:
13373:
13370:
13365:
13360:
13355:
13350:
13345:
13340:
13335:
13330:
13325:
13320:
13315:
13310:
13305:
13300:
13295:
13290:
13285:
13280:
13275:
13270:
13265:
13260:
13255:
13250:
13245:
13240:
13235:
13230:
13225:
13220:
13215:
13210:
13205:
13200:
13194:
13191:
13190:
13180:
13179:
13177:
13176:
13174:Male cosmetics
13171:
13166:
13161:
13156:
13151:
13146:
13141:
13135:
13133:
13129:
13128:
13126:
13125:
13120:
13118:Skin whitening
13115:
13110:
13105:
13100:
13094:
13092:
13088:
13087:
13085:
13084:
13079:
13074:
13069:
13064:
13058:
13056:
13052:
13051:
13049:
13048:
13047:
13046:
13041:
13036:
13031:
13026:
13016:
13011:
13006:
13005:
13004:
12999:
12994:
12989:
12984:
12979:
12974:
12969:
12959:
12954:
12948:
12946:
12942:
12941:
12939:
12938:
12933:
12928:
12923:
12918:
12913:
12908:
12903:
12901:Blepharoplasty
12897:
12895:
12891:
12890:
12888:
12887:
12882:
12877:
12872:
12867:
12861:
12859:
12855:
12854:
12852:
12851:
12846:
12841:
12836:
12831:
12826:
12821:
12816:
12811:
12806:
12801:
12796:
12791:
12786:
12781:
12776:
12771:
12766:
12761:
12756:
12750:
12748:
12744:
12743:
12736:
12735:
12728:
12721:
12713:
12704:
12703:
12701:
12700:
12695:
12690:
12685:
12681:
12678:
12677:
12674:
12673:
12671:
12670:
12665:
12650:
12649:
12632:
12630:
12624:
12623:
12621:
12620:
12617:γ-bungarotoxin
12613:β-bungarotoxin
12602:
12601:
12567:
12566:
12536:
12534:
12525:
12511:
12510:
12507:
12506:
12504:
12503:
12494:
12492:
12481:
12480:
12478:
12477:
12468:
12467:
12462:
12453:
12451:
12437:
12423:
12422:
12419:
12418:
12416:
12415:
12412:
12407:
12402:
12397:
12392:
12387:
12382:
12377:
12372:
12363:
12361:
12350:
12349:
12347:
12346:
12341:
12336:
12331:
12326:
12316:
12315:
12310:
12305:
12300:
12295:
12290:
12285:
12280:
12275:
12270:
12265:
12260:
12255:
12250:
12245:
12240:
12235:
12230:
12225:
12220:
12215:
12210:
12205:
12200:
12195:
12190:
12185:
12180:
12171:
12170:
12165:
12153:
12131:
12122:
12117:
12112:
12107:
12102:
12097:
12092:
12087:
12082:
12077:
12072:
12067:
12062:
12057:
12052:
12047:
12042:
12037:
12032:
12027:
12022:
12017:
12012:
12007:
12002:
11997:
11992:
11987:
11982:
11977:
11972:
11967:
11962:
11957:
11952:
11947:
11942:
11937:
11932:
11927:
11922:
11917:
11912:
11907:
11902:
11897:
11892:
11887:
11882:
11877:
11875:Novichok agent
11872:
11867:
11862:
11857:
11852:
11847:
11842:
11837:
11832:
11827:
11822:
11817:
11812:
11807:
11802:
11797:
11795:Isofluorophate
11792:
11787:
11782:
11777:
11772:
11767:
11762:
11757:
11752:
11747:
11742:
11737:
11732:
11727:
11722:
11717:
11712:
11707:
11702:
11697:
11692:
11687:
11682:
11677:
11672:
11667:
11662:
11657:
11652:
11647:
11642:
11637:
11632:
11627:
11622:
11617:
11612:
11607:
11602:
11597:
11592:
11587:
11582:
11577:
11572:
11567:
11562:
11557:
11552:
11550:Chlorethoxyfos
11547:
11542:
11537:
11532:
11527:
11522:
11520:Azinphos-ethyl
11517:
11512:
11507:
11497:
11496:
11491:
11486:
11481:
11476:
11471:
11466:
11461:
11456:
11451:
11446:
11441:
11436:
11431:
11426:
11421:
11416:
11411:
11406:
11401:
11396:
11391:
11386:
11381:
11372:
11367:
11362:
11360:Pyridostigmine
11357:
11352:
11347:
11339:
11334:
11329:
11320:
11315:
11310:
11305:
11300:
11295:
11290:
11285:
11280:
11275:
11270:
11265:
11260:
11255:
11250:
11245:
11240:
11235:
11230:
11225:
11220:
11215:
11210:
11205:
11200:
11195:
11190:
11185:
11180:
11175:
11159:
11157:
11146:
11145:
11143:
11142:
11137:
11132:
11127:
11122:
11117:
11112:
11107:
11102:
11097:
11092:
11087:
11078:
11076:
11062:
11048:
11047:
11030:
11029:
11022:
11015:
11007:
10998:
10997:
10995:
10994:
10983:
10980:
10979:
10977:
10976:
10970:
10967:
10966:
10963:
10962:
10960:
10959:
10954:
10949:
10944:
10939:
10938:
10937:
10932:
10921:
10919:
10905:
10904:
10902:
10901:
10899:Zetekitoxin AB
10896:
10891:
10886:
10881:
10876:
10871:
10866:
10865:
10864:
10859:
10854:
10849:
10844:
10834:
10829:
10823:
10821:
10812:
10811:
10809:
10808:
10803:
10797:
10795:
10783:
10775:
10774:
10771:
10770:
10768:
10767:
10762:
10757:
10752:
10747:
10741:
10739:
10730:
10729:
10727:
10726:
10721:
10716:
10711:
10706:
10701:
10696:
10695:
10694:
10683:
10681:
10672:
10671:
10669:
10668:
10663:
10658:
10653:
10648:
10643:
10638:
10633:
10628:
10623:
10618:
10613:
10608:
10603:
10598:
10593:
10588:
10583:
10577:
10575:
10563:
10555:
10554:
10552:
10551:
10546:
10545:
10544:
10539:
10529:
10524:
10519:
10514:
10509:
10504:
10499:
10494:
10489:
10484:
10479:
10474:
10469:
10464:
10459:
10454:
10449:
10447:Pseudaconitine
10444:
10439:
10434:
10429:
10424:
10419:
10414:
10409:
10404:
10399:
10394:
10389:
10387:Djenkolic acid
10384:
10379:
10374:
10369:
10364:
10359:
10354:
10349:
10344:
10339:
10333:
10331:
10324:
10323:
10321:
10320:
10315:
10310:
10305:
10300:
10295:
10290:
10285:
10280:
10275:
10270:
10265:
10260:
10255:
10237:
10232:
10227:
10222:
10217:
10210:gamma-amanitin
10202:alpha-amanitin
10195:
10189:
10187:
10181:
10180:
10177:
10176:
10174:
10173:
10168:
10162:
10160:
10152:
10151:
10149:
10148:
10147:
10146:
10141:
10129:
10128:
10127:
10122:
10109:
10108:
10107:
10096:
10094:
10088:
10087:
10084:
10083:
10081:
10080:
10079:
10078:
10062:
10061:
10060:
10048:
10047:
10046:
10033:
10031:
10025:
10024:
10022:
10021:
10016:
10011:
10006:
9997:
9989:
9982:
9980:
9972:
9971:
9968:
9967:
9965:
9964:
9959:
9953:
9951:
9949:Actinomycetota
9945:
9944:
9941:
9940:
9938:
9937:
9932:
9927:
9922:
9908:
9906:
9903:Staphylococcus
9898:
9897:
9895:
9894:
9893:
9892:
9882:
9876:
9870:
9864:
9863:
9860:
9859:
9857:
9856:
9851:
9845:
9843:
9837:
9836:
9834:
9833:
9832:
9831:
9819:
9818:
9817:
9812:
9800:
9799:
9798:
9793:
9781:
9780:
9779:
9774:
9761:
9759:
9747:
9738:
9727:
9718:
9710:
9709:
9707:
9706:
9705:
9704:
9699:
9694:
9689:
9684:
9679:
9674:
9661:
9660:
9653:
9646:
9638:
9629:
9628:
9626:
9625:
9619:
9617:
9611:
9610:
9607:
9606:
9604:
9603:
9598:
9593:
9588:
9583:
9578:
9573:
9568:
9563:
9558:
9553:
9548:
9543:
9538:
9533:
9528:
9523:
9518:
9513:
9508:
9503:
9498:
9493:
9488:
9483:
9478:
9472:
9470:
9466:
9465:
9463:
9462:
9457:
9451:
9449:
9437:
9436:
9434:
9433:
9427:
9425:
9419:
9418:
9416:
9415:
9409:
9407:
9401:
9400:
9398:
9397:
9391:
9389:
9383:
9382:
9380:
9379:
9374:
9369:
9364:
9359:
9354:
9349:
9344:
9338:
9336:
9330:
9329:
9327:
9326:
9321:
9316:
9311:
9306:
9301:
9296:
9291:
9285:
9283:
9273:
9267:
9266:
9263:
9262:
9260:
9259:
9253:
9251:
9245:
9244:
9242:
9241:
9232:
9231:
9218:
9216:
9210:
9209:
9206:
9205:
9203:
9202:
9192:
9191:
9186:
9181:
9176:
9171:
9166:
9161:long duration:
9157:
9156:
9151:
9146:
9141:
9136:
9127:
9126:
9121:
9116:
9110:short duration
9106:
9105:
9096:
9094:
9088:
9087:
9085:
9084:
9079:
9074:
9068:
9066:
9054:
9045:
9028:
9027:
9014:
9013:
9006:
8999:
8991:
8985:
8984:
8972:
8960:
8948:
8936:
8924:
8903:
8882:
8859:
8858:External links
8856:
8855:
8854:
8809:
8762:
8759:
8756:
8755:
8737:
8702:
8673:
8630:
8603:(2): 140–146.
8587:
8560:(6): 921–936.
8543:
8510:
8470:
8449:(4): 339–344.
8429:
8394:
8359:
8318:
8269:
8237:
8211:
8181:
8146:
8106:
8079:(2): 141–146.
8063:
8036:(4): 509–518.
8020:
7971:
7940:
7929:(4): 212–217.
7913:
7876:(5): 575–582.
7856:
7837:(4): 172–180.
7821:
7792:(2): 249–256.
7772:
7732:
7698:
7647:
7596:
7555:
7506:
7469:
7443:
7397:
7360:
7320:
7290:
7260:
7230:
7200:
7193:
7167:
7160:
7142:
7107:
7088:
7068:
7037:
7026:on 1 June 2011
7004:
6974:
6934:
6904:
6874:
6844:
6812:
6785:
6763:
6714:
6679:
6652:(6): 669–676.
6636:
6598:
6579:(6): 469–472.
6563:
6525:
6506:(2): 353–355.
6487:
6452:
6431:on 6 July 2010
6403:
6367:
6324:
6297:
6246:
6227:(5): 489–491.
6211:
6182:(1–2): 10–24.
6162:
6119:
6093:
6074:(3): 292–299.
6058:
6004:
5958:
5908:
5877:(3): 310–317.
5857:
5803:
5788:
5762:
5731:(1): 202–220.
5702:
5673:(1): 811–837.
5650:
5621:(1): 180–185.
5598:
5546:
5527:(2): 183–191.
5511:
5481:
5444:
5414:
5392:
5349:
5312:
5301:on 2 June 2015
5282:
5271:on 1 July 2015
5252:
5222:
5189:
5149:
5108:
5067:
5038:(6): 853–861.
5018:
4989:(6): 853–861.
4969:
4938:(3): 407–415.
4911:
4857:
4826:
4785:
4742:
4708:
4653:
4627:
4570:
4553:refinery29.com
4536:
4525:(3): 168–175.
4500:
4449:
4413:
4383:
4362:(5): 657–666.
4339:
4305:
4256:
4229:(4): 367–373.
4213:
4162:
4122:
4092:
4070:
4051:
4031:
3996:
3965:
3916:
3897:(4): 784–795.
3880:
3829:
3800:(2): 115–135.
3780:
3738:
3697:
3671:
3622:
3593:(2): 132–138.
3573:
3538:
3517:(5): 489–503.
3497:
3456:
3421:
3390:
3334:
3272:
3237:
3208:
3165:
3129:
3083:
3035:
3008:(4): 705–722.
2992:
2973:(3): 274–279.
2944:
2905:
2875:
2840:
2810:
2777:
2747:
2717:
2687:
2657:
2625:
2595:
2569:
2539:
2509:
2483:
2453:
2423:
2393:
2364:
2335:
2304:
2264:
2263:
2261:
2258:
2239:
2236:
2217:
2214:
2190:
2187:
2174:
2171:
2159:
2156:
2132:cerebral palsy
2123:
2120:
2070:
2067:
2032:
2029:
2027:
2024:
1991:
1990:
1970:
1968:
1961:
1955:
1952:
1896:
1893:
1862:
1861:
1822:of the subject
1820:worldwide view
1815:
1813:
1806:
1800:
1797:
1787:Baader-Meinhof
1779:
1758:
1755:
1749:
1746:
1741:
1738:
1732:
1729:
1723:
1720:
1715:
1712:
1698:
1697:
1678:
1676:
1669:
1663:
1660:
1658:
1655:
1642:
1639:
1614:
1611:
1571:electromyogram
1562:
1559:
1551:Chemical Corps
1542:
1539:
1529:
1528:
1487:
1485:
1478:
1472:
1469:
1461:Georgina Burke
1381:
1375:
1373:
1370:
1274:disulfide bond
1251:SNARE proteins
1190:
1187:
1136:Main article:
1133:
1130:
1097:
1094:
1090:cerebral palsy
1073:
1070:
1024:
1021:
995:
992:
983:
980:
945:
942:
893:, post-stroke
891:cerebral palsy
886:
883:
878:
875:
784:
783:
780:
779:
774:
768:
767:
762:
756:
755:
750:
744:
743:
735:
734:
725:
719:
718:
707:
700:
699:
694:
688:
687:
682:
676:
675:
670:
664:
663:
658:
652:
651:
646:
640:
639:
634:
628:
627:
623:
622:
617:
611:
610:
606:
605:
597:
596:
579:
578:
568:
562:
561:
558:
552:
546:
540:
534:
529:
523:
522:
518:
517:
507:
499:
498:
496:
495:
487:
478:
476:
470:
469:
467:
466:
458:
449:
447:
441:
440:
438:
437:
433:
431:
425:
424:
422:
421:
413:
404:
402:
396:
395:
393:
392:
384:
375:
373:
367:
366:
362:
361:
359:
358:
349:
334:
321:
305:
291:
289:
283:
282:
278:
277:
275:
274:
260:
258:
252:
251:
238:
236:administration
230:
229:
227:
226:
224:
214:
212:
204:
203:
201:
200:
182:
180:
174:
173:
166:
160:
159:
157:
156:
148:
140:
132:
124:
116:
107:
105:
95:
94:
90:
84:
83:
80:
76:
75:
72:
66:
65:
61:
60:
36:Ribbon diagram
34:
15:
9:
6:
4:
3:
2:
14534:
14523:
14520:
14518:
14515:
14513:
14510:
14508:
14505:
14503:
14500:
14498:
14495:
14493:
14490:
14488:
14485:
14483:
14480:
14478:
14475:
14473:
14470:
14469:
14467:
14457:
14447:
14445:
14440:
14435:
14434:
14431:
14417:
14413:
14412:
14407:
14404:
14400:
14399:
14394:
14391:
14387:
14386:
14381:
14378:
14374:
14373:
14368:
14365:
14361:
14360:
14355:
14352:
14348:
14347:
14342:
14339:
14335:
14334:
14329:
14328:
14326:
14322:
14316:
14313:
14311:
14308:
14306:
14303:
14301:
14298:
14296:
14293:
14292:
14290:
14286:
14280:
14277:
14275:
14274:Enzyme family
14272:
14270:
14267:
14265:
14262:
14261:
14259:
14255:
14249:
14246:
14244:
14241:
14239:
14238:Cooperativity
14236:
14234:
14231:
14230:
14228:
14224:
14218:
14215:
14213:
14210:
14208:
14205:
14203:
14200:
14198:
14197:Oxyanion hole
14195:
14193:
14190:
14188:
14185:
14183:
14180:
14179:
14177:
14173:
14169:
14162:
14157:
14155:
14150:
14148:
14143:
14142:
14139:
14127:
14124:
14122:
14119:
14117:
14114:
14112:
14109:
14107:
14104:
14102:
14099:
14097:
14094:
14092:
14089:
14088:
14086:
14082:
14076:
14073:
14071:
14068:
14066:
14063:
14061:
14058:
14056:
14053:
14051:
14048:
14046:
14043:
14041:
14038:
14036:
14033:
14031:
14028:
14026:
14023:
14021:
14018:
14016:
14013:
14011:
14008:
14006:
14003:
14001:
13998:
13996:
13993:
13991:
13988:
13986:
13983:
13981:
13978:
13974:
13971:
13969:
13966:
13965:
13964:
13961:
13957:
13954:
13952:
13949:
13948:
13947:
13944:
13943:
13941:
13939:
13935:
13929:
13926:
13924:
13921:
13919:
13916:
13914:
13911:
13909:
13906:
13904:
13901:
13899:
13896:
13894:
13891:
13889:
13886:
13884:
13881:
13879:
13876:
13874:
13871:
13869:
13866:
13864:
13861:
13859:
13856:
13854:
13851:
13849:
13846:
13844:
13841:
13839:
13836:
13834:
13831:
13829:
13826:
13822:
13819:
13817:
13814:
13812:
13809:
13807:
13804:
13803:
13802:
13799:
13798:
13796:
13794:
13793:ADAM proteins
13790:
13785:
13782:
13778:
13774:
13767:
13762:
13760:
13755:
13753:
13748:
13747:
13744:
13732:
13729:
13727:
13724:
13722:
13719:
13711:
13710:
13707:
13697:
13694:
13692:
13689:
13687:
13684:
13682:
13679:
13677:
13674:
13672:
13669:
13667:
13664:
13662:
13659:
13657:
13654:
13652:
13651:The Face Shop
13649:
13647:
13646:The Body Shop
13644:
13642:
13639:
13637:
13634:
13632:
13629:
13627:
13624:
13622:
13621:Sinful Colors
13619:
13617:
13614:
13612:
13609:
13607:
13604:
13602:
13599:
13597:
13594:
13592:
13589:
13587:
13584:
13582:
13579:
13577:
13574:
13572:
13569:
13567:
13564:
13562:
13559:
13557:
13554:
13552:
13549:
13547:
13546:NYX Cosmetics
13544:
13542:
13539:
13537:
13534:
13532:
13529:
13527:
13524:
13522:
13519:
13517:
13514:
13512:
13509:
13507:
13504:
13502:
13499:
13497:
13494:
13492:
13489:
13487:
13484:
13482:
13479:
13477:
13474:
13472:
13469:
13467:
13464:
13462:
13461:MAC Cosmetics
13459:
13457:
13454:
13452:
13449:
13447:
13444:
13442:
13439:
13437:
13434:
13432:
13429:
13427:
13424:
13422:
13419:
13417:
13414:
13412:
13409:
13407:
13404:
13402:
13399:
13397:
13394:
13392:
13389:
13387:
13384:
13382:
13379:
13377:
13374:
13371:
13369:
13366:
13364:
13361:
13359:
13356:
13354:
13351:
13349:
13346:
13344:
13341:
13339:
13336:
13334:
13331:
13329:
13326:
13324:
13321:
13319:
13316:
13314:
13311:
13309:
13306:
13304:
13301:
13299:
13296:
13294:
13291:
13289:
13286:
13284:
13281:
13279:
13276:
13274:
13271:
13269:
13266:
13264:
13261:
13259:
13256:
13254:
13251:
13249:
13246:
13244:
13241:
13239:
13236:
13234:
13231:
13229:
13226:
13224:
13221:
13219:
13216:
13214:
13211:
13209:
13206:
13204:
13201:
13199:
13196:
13195:
13192:
13185:
13181:
13175:
13172:
13170:
13167:
13165:
13162:
13160:
13157:
13155:
13152:
13150:
13147:
13145:
13142:
13140:
13137:
13136:
13134:
13130:
13124:
13121:
13119:
13116:
13114:
13111:
13109:
13106:
13104:
13101:
13099:
13096:
13095:
13093:
13089:
13083:
13080:
13078:
13075:
13073:
13070:
13068:
13065:
13063:
13060:
13059:
13057:
13053:
13045:
13042:
13040:
13037:
13035:
13032:
13030:
13027:
13025:
13022:
13021:
13020:
13017:
13015:
13012:
13010:
13007:
13003:
13000:
12998:
12995:
12993:
12990:
12988:
12985:
12983:
12980:
12978:
12975:
12973:
12970:
12968:
12965:
12964:
12963:
12960:
12958:
12955:
12953:
12950:
12949:
12947:
12943:
12937:
12934:
12932:
12929:
12927:
12924:
12922:
12919:
12917:
12914:
12912:
12909:
12907:
12904:
12902:
12899:
12898:
12896:
12892:
12886:
12883:
12881:
12878:
12876:
12873:
12871:
12868:
12866:
12863:
12862:
12860:
12856:
12850:
12847:
12845:
12842:
12840:
12837:
12835:
12832:
12830:
12827:
12825:
12822:
12820:
12817:
12815:
12812:
12810:
12807:
12805:
12802:
12800:
12799:Facial toning
12797:
12795:
12792:
12790:
12787:
12785:
12782:
12780:
12777:
12775:
12772:
12770:
12767:
12765:
12762:
12760:
12757:
12755:
12752:
12751:
12749:
12745:
12741:
12734:
12729:
12727:
12722:
12720:
12715:
12714:
12711:
12699:
12696:
12694:
12691:
12689:
12686:
12683:
12682:
12679:
12669:
12666:
12663:
12659:
12655:
12652:
12651:
12648:
12645:
12640:
12634:
12633:
12631:
12629:
12625:
12618:
12614:
12610:
12609:Bungarotoxins
12607:
12604:
12603:
12599:
12595:
12591:
12587:
12583:
12580:
12579:inactivators:
12575:
12569:
12568:
12564:
12560:
12556:
12552:
12549:
12548:inactivators:
12544:
12538:
12537:
12535:
12533:
12529:
12526:
12522:
12516:
12512:
12502:
12499:
12496:
12495:
12493:
12488:
12482:
12476:
12473:
12470:
12469:
12466:
12463:
12461:
12458:
12455:
12454:
12452:
12447:
12441:
12438:
12434:
12428:
12424:
12413:
12411:
12410:ZINC-12613047
12408:
12406:
12403:
12401:
12398:
12396:
12393:
12391:
12388:
12386:
12383:
12381:
12378:
12376:
12373:
12371:
12368:
12365:
12364:
12362:
12357:
12351:
12345:
12342:
12340:
12337:
12335:
12332:
12330:
12327:
12325:
12321:
12318:
12317:
12314:
12311:
12309:
12306:
12304:
12301:
12299:
12296:
12294:
12291:
12289:
12286:
12284:
12281:
12279:
12276:
12274:
12271:
12269:
12266:
12264:
12261:
12259:
12256:
12254:
12253:Lactucopicrin
12251:
12249:
12246:
12244:
12241:
12239:
12236:
12234:
12231:
12229:
12226:
12224:
12221:
12219:
12216:
12214:
12211:
12209:
12206:
12204:
12201:
12199:
12196:
12194:
12191:
12189:
12186:
12184:
12181:
12179:
12176:
12173:
12172:
12169:
12166:
12163:
12162:
12157:
12154:
12151:
12147:
12143:
12139:
12135:
12132:
12130:
12126:
12123:
12121:
12118:
12116:
12113:
12111:
12108:
12106:
12103:
12101:
12098:
12096:
12093:
12091:
12088:
12086:
12085:Trichloronate
12083:
12081:
12078:
12076:
12073:
12071:
12068:
12066:
12063:
12061:
12058:
12056:
12053:
12051:
12048:
12046:
12043:
12041:
12038:
12036:
12033:
12031:
12028:
12026:
12023:
12021:
12018:
12016:
12013:
12011:
12008:
12006:
12003:
12001:
11998:
11996:
11993:
11991:
11988:
11986:
11983:
11981:
11978:
11976:
11973:
11971:
11968:
11966:
11963:
11961:
11958:
11956:
11953:
11951:
11948:
11946:
11943:
11941:
11938:
11936:
11933:
11931:
11928:
11926:
11923:
11921:
11918:
11916:
11913:
11911:
11908:
11906:
11903:
11901:
11898:
11896:
11893:
11891:
11888:
11886:
11883:
11881:
11878:
11876:
11873:
11871:
11868:
11866:
11863:
11861:
11860:Monocrotophos
11858:
11856:
11853:
11851:
11848:
11846:
11843:
11841:
11838:
11836:
11833:
11831:
11828:
11826:
11825:Methamidophos
11823:
11821:
11818:
11816:
11813:
11811:
11808:
11806:
11803:
11801:
11798:
11796:
11793:
11791:
11788:
11786:
11783:
11781:
11778:
11776:
11773:
11771:
11768:
11766:
11763:
11761:
11758:
11756:
11753:
11751:
11748:
11746:
11743:
11741:
11738:
11736:
11733:
11731:
11728:
11726:
11723:
11721:
11718:
11716:
11713:
11711:
11708:
11706:
11703:
11701:
11700:Echothiophate
11698:
11696:
11693:
11691:
11688:
11686:
11683:
11681:
11678:
11676:
11673:
11671:
11668:
11666:
11663:
11661:
11658:
11656:
11653:
11651:
11648:
11646:
11643:
11641:
11638:
11636:
11633:
11631:
11628:
11626:
11623:
11621:
11618:
11616:
11613:
11611:
11608:
11606:
11603:
11601:
11598:
11596:
11593:
11591:
11588:
11586:
11583:
11581:
11578:
11576:
11573:
11571:
11568:
11566:
11563:
11561:
11558:
11556:
11553:
11551:
11548:
11546:
11543:
11541:
11538:
11536:
11533:
11531:
11528:
11526:
11523:
11521:
11518:
11516:
11513:
11511:
11508:
11506:
11502:
11501:Irreversible:
11499:
11498:
11495:
11492:
11490:
11487:
11485:
11482:
11480:
11477:
11475:
11472:
11470:
11467:
11465:
11462:
11460:
11457:
11455:
11452:
11450:
11447:
11445:
11442:
11440:
11437:
11435:
11432:
11430:
11427:
11425:
11422:
11420:
11417:
11415:
11412:
11410:
11407:
11405:
11402:
11400:
11397:
11395:
11392:
11390:
11387:
11385:
11382:
11380:
11376:
11373:
11371:
11368:
11366:
11365:Quilostigmine
11363:
11361:
11358:
11356:
11355:Physostigmine
11353:
11351:
11348:
11346:
11343:
11340:
11338:
11335:
11333:
11330:
11328:
11325:; Stigmines:
11324:
11321:
11319:
11316:
11314:
11311:
11309:
11306:
11304:
11301:
11299:
11296:
11294:
11291:
11289:
11286:
11284:
11281:
11279:
11276:
11274:
11271:
11269:
11266:
11264:
11261:
11259:
11256:
11254:
11251:
11249:
11246:
11244:
11241:
11239:
11236:
11234:
11231:
11229:
11226:
11224:
11223:Chloropropham
11221:
11219:
11216:
11214:
11211:
11209:
11206:
11204:
11201:
11199:
11196:
11194:
11191:
11189:
11186:
11184:
11181:
11179:
11176:
11174:
11170:
11167:
11165:
11161:
11160:
11158:
11153:
11147:
11141:
11138:
11136:
11133:
11131:
11128:
11126:
11123:
11121:
11118:
11116:
11113:
11111:
11108:
11106:
11103:
11101:
11098:
11096:
11093:
11091:
11088:
11086:
11083:
11080:
11079:
11077:
11072:
11066:
11063:
11059:
11053:
11049:
11045:
11042:
11038:
11035:
11034:Acetylcholine
11028:
11023:
11021:
11016:
11014:
11009:
11008:
11005:
10993:
10985:
10984:
10981:
10975:
10972:
10971:
10968:
10958:
10955:
10953:
10950:
10948:
10945:
10943:
10940:
10936:
10933:
10931:
10928:
10927:
10926:
10923:
10922:
10920:
10916:
10911:
10906:
10900:
10897:
10895:
10892:
10890:
10889:Samandaridine
10887:
10885:
10882:
10880:
10877:
10875:
10872:
10870:
10867:
10863:
10862:Marinobufagin
10860:
10858:
10855:
10853:
10850:
10848:
10845:
10843:
10840:
10839:
10838:
10835:
10833:
10832:Batrachotoxin
10830:
10828:
10825:
10824:
10822:
10818:
10813:
10807:
10804:
10802:
10799:
10798:
10796:
10792:
10787:
10784:
10780:
10776:
10766:
10763:
10761:
10758:
10756:
10753:
10751:
10748:
10746:
10743:
10742:
10740:
10736:
10731:
10725:
10722:
10720:
10717:
10715:
10712:
10710:
10707:
10705:
10702:
10700:
10697:
10693:
10690:
10689:
10688:
10685:
10684:
10682:
10678:
10673:
10667:
10664:
10662:
10659:
10657:
10654:
10652:
10649:
10647:
10644:
10642:
10639:
10637:
10634:
10632:
10629:
10627:
10624:
10622:
10619:
10617:
10614:
10612:
10609:
10607:
10604:
10602:
10599:
10597:
10594:
10592:
10589:
10587:
10586:Charybdotoxin
10584:
10582:
10579:
10578:
10576:
10572:
10567:
10564:
10560:
10556:
10550:
10547:
10543:
10540:
10538:
10535:
10534:
10533:
10530:
10528:
10525:
10523:
10520:
10518:
10515:
10513:
10510:
10508:
10505:
10503:
10500:
10498:
10497:Solauricidine
10495:
10493:
10490:
10488:
10485:
10483:
10480:
10478:
10475:
10473:
10470:
10468:
10465:
10463:
10460:
10458:
10455:
10453:
10450:
10448:
10445:
10443:
10442:Protoanemonin
10440:
10438:
10435:
10433:
10430:
10428:
10427:Oenanthotoxin
10425:
10423:
10420:
10418:
10415:
10413:
10410:
10408:
10405:
10403:
10400:
10398:
10395:
10393:
10390:
10388:
10385:
10383:
10380:
10378:
10375:
10373:
10370:
10368:
10365:
10363:
10360:
10358:
10355:
10353:
10350:
10348:
10345:
10343:
10340:
10338:
10335:
10334:
10332:
10329:
10325:
10319:
10316:
10314:
10311:
10309:
10306:
10304:
10303:Trichothecene
10301:
10299:
10296:
10294:
10291:
10289:
10286:
10284:
10281:
10279:
10276:
10274:
10271:
10269:
10266:
10264:
10263:Ibotenic acid
10261:
10259:
10256:
10253:
10249:
10245:
10241:
10238:
10236:
10233:
10231:
10228:
10226:
10223:
10221:
10218:
10215:
10211:
10207:
10206:beta-amanitin
10203:
10199:
10196:
10194:
10191:
10190:
10188:
10186:
10182:
10172:
10169:
10167:
10164:
10163:
10161:
10159:
10153:
10145:
10142:
10140:
10137:
10136:
10134:
10130:
10126:
10123:
10121:
10118:
10117:
10116:
10114:
10110:
10106:
10103:
10102:
10101:
10098:
10097:
10095:
10093:
10089:
10077:
10073:
10070:
10069:
10068:
10067:
10063:
10059:
10056:
10055:
10054:
10053:
10049:
10045:
10042:
10041:
10040:
10039:
10035:
10034:
10032:
10030:
10026:
10020:
10017:
10015:
10012:
10010:
10007:
10005:
10001:
10000:Cholera toxin
9998:
9996:
9994:
9990:
9987:
9984:
9983:
9981:
9979:
9973:
9963:
9960:
9958:
9955:
9954:
9952:
9950:
9946:
9936:
9933:
9931:
9928:
9926:
9923:
9921:
9917:
9913:
9910:
9909:
9907:
9904:
9899:
9891:
9888:
9887:
9886:
9883:
9881:
9878:
9877:
9874:
9871:
9869:
9865:
9855:
9852:
9850:
9849:Anthrax toxin
9847:
9846:
9844:
9838:
9830:
9827:
9826:
9825:
9824:
9820:
9816:
9813:
9811:
9808:
9807:
9806:
9805:
9801:
9797:
9794:
9792:
9789:
9788:
9787:
9786:
9782:
9778:
9775:
9773:
9772:Tetanospasmin
9770:
9769:
9768:
9767:
9763:
9762:
9760:
9756:
9751:
9748:
9746:
9742:
9739:
9737:
9731:
9728:
9726:
9722:
9719:
9717:
9711:
9703:
9700:
9698:
9695:
9693:
9690:
9688:
9685:
9683:
9680:
9678:
9675:
9673:
9670:
9669:
9668:
9665:
9664:
9659:
9654:
9652:
9647:
9645:
9640:
9639:
9636:
9624:
9621:
9620:
9618:
9616:
9612:
9602:
9599:
9597:
9594:
9592:
9589:
9587:
9584:
9582:
9579:
9577:
9574:
9572:
9569:
9567:
9564:
9562:
9559:
9557:
9554:
9552:
9551:Methocarbamol
9549:
9547:
9544:
9542:
9541:Mephenoxalone
9539:
9537:
9534:
9532:
9529:
9527:
9524:
9522:
9519:
9517:
9514:
9512:
9509:
9507:
9504:
9502:
9499:
9497:
9496:Chlorzoxazone
9494:
9492:
9491:Chlorphenesin
9489:
9487:
9486:Chlormezanone
9484:
9482:
9479:
9477:
9474:
9473:
9471:
9467:
9461:
9458:
9456:
9453:
9452:
9450:
9447:
9442:
9438:
9432:
9429:
9428:
9426:
9424:
9420:
9414:
9411:
9410:
9408:
9406:
9402:
9396:
9393:
9392:
9390:
9388:
9384:
9378:
9375:
9373:
9370:
9368:
9365:
9363:
9360:
9358:
9357:Flunitrazepam
9355:
9353:
9350:
9348:
9345:
9343:
9340:
9339:
9337:
9335:
9331:
9325:
9322:
9320:
9317:
9315:
9314:Phenprobamate
9312:
9310:
9307:
9305:
9302:
9300:
9299:Difebarbamate
9297:
9295:
9292:
9290:
9287:
9286:
9284:
9281:
9280:Carbamic acid
9277:
9274:
9272:
9268:
9258:
9255:
9254:
9252:
9250:
9246:
9240:
9239:Hexamethonium
9237:
9234:
9233:
9229:
9228:Suxamethonium
9226:
9224:
9220:
9219:
9217:
9215:
9211:
9200:
9199:Hexafluronium
9197:
9194:
9193:
9190:
9187:
9185:
9182:
9180:
9177:
9175:
9172:
9170:
9167:
9165:
9162:
9159:
9158:
9155:
9152:
9150:
9147:
9145:
9142:
9140:
9139:Cisatracurium
9137:
9135:
9132:
9129:
9128:
9125:
9122:
9120:
9117:
9115:
9111:
9108:
9107:
9104:
9101:
9098:
9097:
9095:
9093:
9089:
9083:
9080:
9078:
9075:
9073:
9070:
9069:
9067:
9065:
9062:
9058:
9055:
9053:
9049:
9046:
9043:
9038:
9037:antinicotinic
9033:
9029:
9024:
9020:
9012:
9007:
9005:
9000:
8998:
8993:
8992:
8989:
8981:
8977:
8973:
8969:
8965:
8961:
8957:
8953:
8949:
8945:
8941:
8937:
8933:
8929:
8925:
8922:
8918:
8917:
8912:
8908:
8904:
8901:
8897:
8896:
8891:
8887:
8883:
8880:
8876:
8875:
8870:
8866:
8862:
8861:
8851:
8847:
8842:
8837:
8832:
8827:
8823:
8819:
8815:
8810:
8806:
8802:
8797:
8792:
8787:
8782:
8778:
8774:
8770:
8765:
8764:
8753:
8749:
8748:
8741:
8733:
8729:
8725:
8721:
8717:
8713:
8706:
8690:
8686:
8680:
8678:
8669:
8665:
8661:
8657:
8653:
8649:
8645:
8641:
8634:
8626:
8622:
8618:
8614:
8610:
8606:
8602:
8598:
8591:
8583:
8579:
8575:
8571:
8567:
8563:
8559:
8555:
8547:
8531:
8527:
8526:
8521:
8514:
8507:
8506:public domain
8488:
8484:
8480:
8474:
8466:
8462:
8457:
8452:
8448:
8444:
8440:
8433:
8425:
8421:
8417:
8413:
8409:
8405:
8398:
8390:
8386:
8382:
8378:
8374:
8370:
8363:
8355:
8351:
8346:
8341:
8337:
8333:
8329:
8322:
8314:
8310:
8305:
8300:
8296:
8292:
8288:
8284:
8280:
8273:
8257:
8253:
8252:
8247:
8241:
8225:
8221:
8215:
8199:
8195:
8191:
8185:
8177:
8173:
8169:
8165:
8161:
8157:
8150:
8143:
8142:public domain
8124:
8120:
8116:
8110:
8102:
8098:
8094:
8090:
8086:
8082:
8078:
8074:
8067:
8059:
8055:
8051:
8047:
8043:
8039:
8035:
8031:
8024:
8016:
8012:
8007:
8002:
7998:
7994:
7990:
7986:
7982:
7975:
7967:
7963:
7959:
7955:
7951:
7950:Ophthalmology
7944:
7936:
7932:
7928:
7924:
7917:
7909:
7905:
7900:
7895:
7891:
7887:
7883:
7879:
7875:
7871:
7867:
7860:
7852:
7848:
7844:
7840:
7836:
7832:
7825:
7817:
7813:
7808:
7803:
7799:
7795:
7791:
7787:
7783:
7776:
7757:
7753:
7751:
7742:
7736:
7720:
7716:
7714:
7708:
7702:
7694:
7690:
7685:
7680:
7675:
7670:
7666:
7662:
7658:
7651:
7643:
7639:
7634:
7629:
7624:
7619:
7615:
7611:
7607:
7600:
7584:
7580:
7578:
7572:
7566:
7564:
7562:
7560:
7551:
7547:
7542:
7537:
7533:
7529:
7525:
7521:
7517:
7510:
7491:
7487:
7480:
7473:
7457:
7453:
7447:
7439:
7435:
7430:
7425:
7421:
7417:
7413:
7406:
7404:
7402:
7395:See PDF p. 7.
7381:
7377:
7370:
7364:
7357:
7356:public domain
7338:
7334:
7330:
7324:
7308:
7304:
7300:
7294:
7278:
7274:
7270:
7264:
7248:
7244:
7240:
7234:
7218:
7214:
7210:
7204:
7196:
7190:
7186:
7182:
7178:
7171:
7163:
7157:
7153:
7146:
7139:
7124:
7121:. U.S. Army.
7117:
7111:
7095:
7091:
7085:
7081:
7080:
7072:
7056:
7052:
7050:
7041:
7025:
7021:
7020:
7015:
7008:
6992:
6988:
6984:
6978:
6959:
6955:
6951:
6944:
6938:
6922:
6918:
6914:
6908:
6892:
6888:
6884:
6878:
6862:
6858:
6854:
6848:
6829:
6822:
6816:
6800:
6796:
6789:
6781:
6777:
6773:
6767:
6759:
6755:
6750:
6745:
6741:
6737:
6733:
6729:
6725:
6718:
6710:
6706:
6702:
6698:
6694:
6690:
6683:
6675:
6671:
6667:
6663:
6659:
6655:
6651:
6647:
6640:
6632:
6628:
6624:
6620:
6616:
6612:
6605:
6603:
6594:
6590:
6586:
6582:
6578:
6574:
6567:
6559:
6555:
6551:
6547:
6543:
6539:
6532:
6530:
6521:
6517:
6513:
6509:
6505:
6501:
6494:
6492:
6483:
6479:
6475:
6471:
6467:
6463:
6462:Health Policy
6456:
6449:
6448:public domain
6427:
6423:
6416:
6410:
6408:
6391:
6387:
6386:
6381:
6374:
6372:
6363:
6359:
6355:
6351:
6347:
6343:
6339:
6335:
6334:Ophthalmology
6328:
6320:
6316:
6312:
6308:
6301:
6293:
6289:
6285:
6281:
6277:
6273:
6269:
6265:
6261:
6257:
6250:
6242:
6238:
6234:
6230:
6226:
6222:
6221:Ophthalmology
6215:
6207:
6203:
6198:
6193:
6189:
6185:
6181:
6177:
6173:
6166:
6158:
6154:
6150:
6146:
6142:
6138:
6134:
6130:
6123:
6107:
6103:
6097:
6089:
6085:
6081:
6077:
6073:
6069:
6062:
6054:
6050:
6045:
6040:
6036:
6032:
6028:
6024:
6020:
6013:
6011:
6009:
6000:
5996:
5992:
5988:
5984:
5980:
5976:
5972:
5965:
5963:
5954:
5950:
5946:
5942:
5938:
5934:
5930:
5926:
5919:
5917:
5915:
5913:
5904:
5900:
5895:
5890:
5885:
5880:
5876:
5872:
5868:
5861:
5853:
5849:
5844:
5839:
5834:
5829:
5825:
5821:
5817:
5810:
5808:
5799:
5795:
5791:
5785:
5781:
5777:
5773:
5766:
5758:
5754:
5749:
5744:
5739:
5734:
5730:
5726:
5722:
5715:
5713:
5711:
5709:
5707:
5698:
5694:
5689:
5684:
5680:
5676:
5672:
5668:
5664:
5657:
5655:
5646:
5642:
5638:
5634:
5629:
5624:
5620:
5616:
5612:
5605:
5603:
5594:
5590:
5585:
5580:
5576:
5572:
5568:
5564:
5560:
5553:
5551:
5542:
5538:
5534:
5530:
5526:
5522:
5515:
5499:
5495:
5491:
5485:
5469:
5465:
5461:
5455:
5453:
5451:
5449:
5432:
5428:
5424:
5418:
5410:
5406:
5402:
5396:
5389:
5388:public domain
5370:
5366:
5362:
5356:
5354:
5337:
5333:
5329:
5323:
5321:
5319:
5317:
5300:
5296:
5292:
5286:
5270:
5266:
5262:
5256:
5240:
5236:
5232:
5226:
5210:
5206:
5202:
5196:
5194:
5186:
5185:public domain
5167:
5163:
5159:
5153:
5137:
5133:
5129:
5125:
5120:
5112:
5104:
5100:
5095:
5090:
5086:
5082:
5078:
5071:
5063:
5059:
5054:
5049:
5045:
5041:
5037:
5033:
5029:
5022:
5014:
5010:
5005:
5000:
4996:
4992:
4988:
4984:
4980:
4973:
4957:
4953:
4949:
4945:
4941:
4937:
4933:
4929:
4922:
4920:
4918:
4916:
4907:
4903:
4898:
4893:
4888:
4883:
4879:
4875:
4871:
4864:
4862:
4853:
4849:
4845:
4841:
4837:
4830:
4822:
4818:
4813:
4808:
4804:
4800:
4796:
4789:
4781:
4777:
4773:
4769:
4765:
4761:
4757:
4753:
4746:
4730:
4726:
4724:
4718:
4712:
4705:
4704:public domain
4686:
4682:
4680:
4674:
4668:
4666:
4664:
4662:
4660:
4658:
4641:
4637:
4631:
4624:
4623:public domain
4605:
4601:
4599:
4593:
4587:
4585:
4583:
4581:
4579:
4577:
4575:
4558:
4554:
4550:
4543:
4541:
4532:
4528:
4524:
4520:
4513:
4511:
4509:
4507:
4505:
4496:
4492:
4487:
4482:
4477:
4472:
4468:
4464:
4460:
4453:
4434:
4430:
4423:
4417:
4401:
4397:
4393:
4387:
4379:
4375:
4370:
4365:
4361:
4357:
4353:
4346:
4344:
4327:
4323:
4319:
4312:
4310:
4301:
4297:
4292:
4287:
4283:
4279:
4275:
4271:
4267:
4260:
4252:
4248:
4244:
4240:
4236:
4232:
4228:
4224:
4217:
4209:
4205:
4200:
4195:
4190:
4185:
4181:
4177:
4173:
4166:
4159:
4158:public domain
4140:
4136:
4132:
4126:
4110:
4106:
4102:
4096:
4089:
4085:
4082:
4077:
4075:
4058:
4054:
4048:
4044:
4043:
4035:
4027:
4023:
4019:
4015:
4011:
4007:
4000:
3992:
3988:
3984:
3980:
3976:
3969:
3961:
3957:
3952:
3947:
3943:
3939:
3935:
3931:
3927:
3920:
3912:
3908:
3904:
3900:
3896:
3892:
3884:
3876:
3872:
3867:
3862:
3857:
3852:
3848:
3844:
3840:
3833:
3825:
3821:
3816:
3811:
3807:
3803:
3799:
3795:
3791:
3784:
3776:
3772:
3768:
3764:
3760:
3756:
3749:
3747:
3745:
3743:
3734:
3730:
3725:
3720:
3716:
3712:
3708:
3701:
3685:
3681:
3675:
3667:
3663:
3658:
3653:
3649:
3645:
3642:: 8160–8171.
3641:
3637:
3633:
3626:
3618:
3614:
3609:
3604:
3600:
3596:
3592:
3588:
3584:
3577:
3569:
3565:
3561:
3557:
3553:
3549:
3542:
3534:
3530:
3525:
3520:
3516:
3512:
3508:
3501:
3493:
3489:
3484:
3479:
3475:
3471:
3467:
3460:
3444:
3440:
3436:
3430:
3428:
3426:
3409:
3405:
3401:
3394:
3386:
3382:
3377:
3372:
3368:
3364:
3360:
3356:
3352:
3345:
3343:
3341:
3339:
3330:
3326:
3321:
3316:
3311:
3306:
3302:
3298:
3294:
3287:
3285:
3283:
3281:
3279:
3277:
3260:
3256:
3252:
3246:
3244:
3242:
3225:
3221:
3215:
3213:
3204:
3200:
3196:
3192:
3188:
3184:
3180:
3176:
3169:
3160:
3155:
3151:
3147:
3143:
3136:
3134:
3125:
3121:
3117:
3113:
3109:
3105:
3101:
3097:
3090:
3088:
3079:
3075:
3071:
3067:
3063:
3059:
3055:
3051:
3044:
3042:
3040:
3031:
3027:
3023:
3019:
3015:
3011:
3007:
3003:
2996:
2988:
2984:
2980:
2976:
2972:
2968:
2961:
2959:
2957:
2955:
2953:
2951:
2949:
2932:
2928:
2924:
2918:
2916:
2914:
2912:
2910:
2893:
2889:
2885:
2879:
2863:
2859:
2855:
2849:
2847:
2845:
2828:
2824:
2820:
2814:
2798:
2794:
2790:
2784:
2782:
2765:
2761:
2757:
2751:
2735:
2731:
2727:
2721:
2705:
2701:
2697:
2691:
2675:
2671:
2667:
2661:
2645:
2641:
2640:
2639:Health Canada
2635:
2629:
2613:
2609:
2605:
2599:
2583:
2579:
2573:
2557:
2553:
2552:Health Canada
2549:
2543:
2527:
2523:
2522:Health Canada
2519:
2513:
2497:
2493:
2487:
2471:
2467:
2463:
2457:
2441:
2437:
2433:
2427:
2411:
2407:
2403:
2397:
2382:
2378:
2374:
2368:
2352:
2348:
2342:
2340:
2323:
2319:
2313:
2311:
2309:
2292:
2288:
2282:
2280:
2278:
2276:
2274:
2272:
2270:
2265:
2257:
2255:
2251:
2245:
2235:
2233:
2229:
2223:
2213:
2210:
2205:
2202:
2196:
2186:
2184:
2180:
2170:
2168:
2164:
2155:
2153:
2149:
2145:
2141:
2137:
2133:
2129:
2119:
2117:
2113:
2109:
2105:
2101:
2096:
2094:
2090:
2085:
2079:
2077:
2066:
2064:
2059:
2057:
2052:
2048:
2045:
2044:blepharospasm
2038:
2023:
2021:
2017:
2013:
2009:
2005:
2000:
1998:
1987:
1984:February 2015
1978:
1974:
1971:This section
1969:
1965:
1960:
1959:
1951:
1949:
1945:
1941:
1936:
1934:
1930:
1925:
1923:
1918:
1917:
1912:
1911:
1906:
1902:
1892:
1890:
1885:
1882:
1877:
1871:
1868:
1858:
1855:
1847:
1837:
1833:
1829:
1823:
1821:
1814:
1805:
1804:
1796:
1794:
1793:
1788:
1783:
1776:
1772:
1768:
1764:
1754:
1745:
1740:Hyperhidrosis
1737:
1728:
1719:
1711:
1707:
1705:
1694:
1682:
1677:
1668:
1667:
1654:
1652:
1647:
1638:
1636:
1631:
1629:
1619:
1610:
1608:
1604:
1603:blepharospasm
1598:
1594:
1592:
1587:
1584:
1583:Alan B. Scott
1580:
1576:
1572:
1568:
1558:
1554:
1552:
1548:
1538:
1536:
1525:
1522:
1514:
1504:
1500:
1494:
1493:
1488:This section
1486:
1482:
1477:
1476:
1468:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1429:
1425:
1421:
1416:
1413:
1408:
1403:
1399:
1395:
1394:blood sausage
1391:
1387:
1380:
1369:
1367:
1366:
1360:
1355:
1354:
1348:
1342:
1337:
1333:
1329:
1327:
1322:
1321:tetanus toxin
1318:
1314:
1313:Anthrax toxin
1310:
1305:
1303:
1297:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1258:
1256:
1252:
1248:
1244:
1243:synaptotagmin
1240:
1236:
1232:
1228:
1224:
1220:
1219:acetylcholine
1216:
1208:
1204:
1200:
1195:
1186:
1184:
1180:
1176:
1171:
1169:
1165:
1161:
1156:
1154:
1149:
1145:
1139:
1129:
1127:
1126:Health Canada
1121:
1119:
1115:
1109:
1107:
1102:
1093:
1091:
1087:
1083:
1079:
1069:
1065:
1061:
1058:
1054:
1050:
1046:
1042:
1038:
1029:
1023:Cosmetic uses
1020:
1018:
1015:
1012:
1008:
1005:
1001:
1000:intramuscular
991:
989:
988:hyperhidrosis
979:
977:
973:
972:off-label use
968:
964:
959:
957:
952:
950:
941:
939:
936:
932:
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
882:
874:
864:
860:
859:intravenously
856:
849:
843:
839:
837:
833:
829:
825:
821:
820:acetylcholine
818:
814:
813:
809:
805:
802:
798:
794:
790:
778:
775:
773:
769:
766:
763:
761:
757:
754:
751:
749:
745:
740:
736:
733:
729:
726:
724:
723:Gene Ontology
720:
717:
714:
711:
708:
705:
701:
698:
695:
693:
689:
686:
683:
681:
677:
674:
671:
669:
665:
662:
661:NiceZyme view
659:
657:
653:
650:
647:
645:
641:
638:
635:
633:
629:
624:
621:
618:
616:
612:
607:
602:
593:
586:
580:
569:
567:
563:
530:
528:
524:
519:
515:
511:
508:
506:
504:ECHA InfoCard
500:
493:
488:
485:
480:
479:
477:
475:
471:
464:
459:
456:
451:
450:
448:
446:
442:
435:
434:
432:
430:
426:
419:
414:
411:
406:
405:
403:
401:
397:
390:
385:
382:
377:
376:
374:
372:
368:
363:
357: Rx-only
350:
347:
335:
332:
322:
315:
306:
303:
293:
292:
290:
288:
284:
279:
271:
266:
262:
261:
259:
257:
253:
250:
246:
242:
241:Intramuscular
239:
237:
231:
225:
216:
215:
213:
211:
205:
198:
193:
184:
183:
181:
179:
175:
171:
167:
165:
161:
154:
149:
146:
141:
138:
133:
130:
125:
122:
117:
114:
109:
108:
106:
104:
100:
96:
91:
89:
85:
81:
77:
73:
71:
67:
64:Clinical data
62:
56:
51:
46:
41:
37:
32:
27:
19:
14411:Translocases
14408:
14395:
14382:
14369:
14356:
14346:Transferases
14343:
14330:
14187:Binding site
13946:Collagenases
13571:Paula Begoun
13496:Molton Brown
13486:Merle Norman
13406:Kevyn Aucoin
13368:Fenty Beauty
13343:Estée Lauder
13208:Amorepacific
12763:
12653:
12647:α-Latrotoxin
12635:
12605:
12581:
12570:
12550:
12539:
12497:
12471:
12456:
12400:Rivastigmine
12366:
12320:Reactivators
12293:Ungiminorine
12248:Kobophenol A
12213:Coronaridine
12203:Bulbocapnine
12198:Arisugacin A
12174:
12159:
12045:Tebupirimfos
11925:Phosphamidon
11830:Methidathion
11735:Fenitrothion
11560:Chlorpyrifos
11500:
11375:Terestigmine
11370:Rivastigmine
11332:Eptastigmine
11283:Phenmedipham
11253:Formparanate
11238:Ethiofencarb
11171:Carbamates:
11168:
11162:
11081:
10973:
10952:Calcicludine
10942:Calciseptine
10925:Bungarotoxin
10894:Tarichatoxin
10842:Arenobufagin
10806:Tetrodotoxin
10765:Tetrodotoxin
10719:Vanillotoxin
10656:Phaiodotoxin
10559:Invertebrate
10482:Solasodamine
10417:Lotaustralin
10252:Fumonisin B4
10248:Fumonisin B2
10244:Fumonisin B1
10230:Cytochalasin
10132:
10112:
10064:
10050:
10044:Superantigen
10036:
9992:
9880:Streptolysin
9828:
9821:
9802:
9783:
9764:
9601:Zoxazolamine
9460:Orphenadrine
9431:Methaqualone
9423:Quinazolines
9294:Cyclarbamate
9289:Carisoprodol
9256:
9235:
9221:
9214:Depolarizing
9195:
9179:Pipecuronium
9160:
9130:
9114:Rapacuronium
9109:
9099:
9082:Tubocurarine
8979:
8967:
8955:
8943:
8931:
8914:
8893:
8872:
8821:
8817:
8779:(1): 45–58.
8776:
8772:
8745:
8740:
8715:
8711:
8705:
8693:. Retrieved
8643:
8639:
8633:
8600:
8596:
8590:
8557:
8553:
8546:
8534:. Retrieved
8523:
8513:
8491:. Retrieved
8487:the original
8473:
8446:
8442:
8432:
8407:
8403:
8397:
8375:(1): 76–82.
8372:
8368:
8362:
8338:(1): 70–77.
8335:
8331:
8321:
8286:
8282:
8272:
8260:. Retrieved
8249:
8240:
8228:. Retrieved
8224:the original
8214:
8202:. Retrieved
8184:
8162:(6): 55–68.
8159:
8155:
8149:
8127:. Retrieved
8123:the original
8109:
8076:
8072:
8066:
8033:
8029:
8023:
7991:(2): 82–91.
7988:
7984:
7974:
7949:
7943:
7926:
7922:
7916:
7873:
7869:
7859:
7834:
7830:
7824:
7789:
7785:
7775:
7763:. Retrieved
7747:
7735:
7723:. Retrieved
7710:
7701:
7664:
7660:
7650:
7613:
7609:
7599:
7587:. Retrieved
7574:
7526:(1): 80–99.
7523:
7519:
7509:
7497:. Retrieved
7490:the original
7485:
7472:
7460:. Retrieved
7446:
7422:(2): 31–39.
7419:
7415:
7387:. Retrieved
7363:
7341:. Retrieved
7323:
7311:. Retrieved
7293:
7281:. Retrieved
7272:
7263:
7251:. Retrieved
7233:
7221:. Retrieved
7217:the original
7203:
7176:
7170:
7151:
7145:
7137:
7132:16 September
7130:. Retrieved
7110:
7098:. Retrieved
7078:
7071:
7059:. Retrieved
7048:
7040:
7028:. Retrieved
7024:the original
7017:
7007:
6995:. Retrieved
6986:
6977:
6965:. Retrieved
6949:
6937:
6925:. Retrieved
6916:
6907:
6895:. Retrieved
6886:
6877:
6865:. Retrieved
6856:
6847:
6835:. Retrieved
6815:
6803:. Retrieved
6799:the original
6788:
6780:the original
6775:
6766:
6731:
6727:
6717:
6692:
6688:
6682:
6649:
6645:
6639:
6617:(1): 17–21.
6614:
6610:
6576:
6572:
6566:
6541:
6537:
6503:
6499:
6465:
6461:
6455:
6433:. Retrieved
6426:the original
6394:. Retrieved
6383:
6337:
6333:
6327:
6310:
6306:
6300:
6259:
6255:
6249:
6224:
6220:
6214:
6179:
6175:
6165:
6132:
6128:
6122:
6110:. Retrieved
6096:
6071:
6067:
6061:
6026:
6022:
5974:
5970:
5928:
5924:
5874:
5871:FEBS Letters
5870:
5860:
5823:
5819:
5771:
5765:
5728:
5724:
5670:
5666:
5618:
5614:
5566:
5562:
5524:
5520:
5514:
5502:. Retrieved
5493:
5484:
5472:. Retrieved
5435:. Retrieved
5417:
5404:
5395:
5373:. Retrieved
5369:the original
5340:. Retrieved
5303:. Retrieved
5299:the original
5285:
5273:. Retrieved
5269:the original
5255:
5243:. Retrieved
5239:the original
5225:
5213:. Retrieved
5204:
5170:. Retrieved
5166:the original
5152:
5140:. Retrieved
5123:
5111:
5087:(8): 16–18.
5084:
5080:
5070:
5035:
5031:
5021:
4986:
4982:
4972:
4960:. Retrieved
4935:
4931:
4877:
4873:
4835:
4829:
4802:
4798:
4788:
4758:(1): 73–83.
4755:
4751:
4745:
4733:. Retrieved
4720:
4711:
4689:. Retrieved
4676:
4646:24 September
4644:. Retrieved
4630:
4608:. Retrieved
4595:
4561:. Retrieved
4552:
4522:
4518:
4466:
4462:
4452:
4440:. Retrieved
4428:
4416:
4404:. Retrieved
4395:
4386:
4359:
4355:
4330:. Retrieved
4273:
4269:
4259:
4226:
4222:
4216:
4179:
4175:
4165:
4143:. Retrieved
4125:
4113:. Retrieved
4104:
4095:
4061:. Retrieved
4045:. Elsevier.
4041:
4034:
4012:(2): 85–88.
4009:
4005:
3999:
3974:
3968:
3936:(4): 62–65.
3933:
3929:
3919:
3894:
3890:
3883:
3846:
3842:
3832:
3797:
3793:
3783:
3758:
3754:
3714:
3710:
3700:
3688:. Retrieved
3674:
3639:
3635:
3625:
3590:
3586:
3576:
3551:
3547:
3541:
3514:
3510:
3500:
3473:
3470:FEBS Letters
3469:
3459:
3447:. Retrieved
3438:
3412:. Retrieved
3403:
3393:
3358:
3354:
3303:(3): e0119.
3300:
3297:JBJS Reviews
3296:
3263:. Retrieved
3254:
3228:. Retrieved
3178:
3174:
3168:
3149:
3145:
3099:
3095:
3056:(1): 11–18.
3053:
3049:
3005:
3001:
2995:
2970:
2966:
2937:27 September
2935:. Retrieved
2926:
2896:. Retrieved
2887:
2878:
2866:. Retrieved
2857:
2831:. Retrieved
2822:
2813:
2801:. Retrieved
2792:
2768:. Retrieved
2759:
2750:
2738:. Retrieved
2729:
2720:
2708:. Retrieved
2699:
2690:
2678:. Retrieved
2669:
2660:
2648:. Retrieved
2637:
2628:
2616:. Retrieved
2607:
2598:
2586:. Retrieved
2581:
2572:
2560:. Retrieved
2551:
2542:
2530:. Retrieved
2521:
2512:
2500:. Retrieved
2486:
2474:. Retrieved
2465:
2456:
2444:. Retrieved
2435:
2426:
2414:. Retrieved
2405:
2396:
2384:. Retrieved
2376:
2367:
2355:. Retrieved
2350:
2326:. Retrieved
2295:. Retrieved
2290:
2247:
2225:
2206:
2198:
2176:
2167:Bell's palsy
2161:
2125:
2097:
2080:
2075:
2072:
2060:
2053:
2049:
2040:
2020:hydroxamates
2001:
1996:
1994:
1981:
1977:adding to it
1972:
1939:
1937:
1928:
1920:
1914:
1908:
1904:
1901:Clostridium,
1900:
1898:
1886:
1872:
1869:
1865:
1850:
1841:
1817:
1790:
1784:
1763:bioterrorism
1760:
1757:Bioterrorism
1751:
1743:
1734:
1725:
1717:
1708:
1701:
1691:October 2017
1688:
1680:
1644:
1641:Chronic pain
1632:
1627:
1624:
1599:
1595:
1588:
1564:
1555:
1547:Fort Detrick
1544:
1541:World War II
1532:
1517:
1508:
1497:Please help
1492:verification
1489:
1471:Food canning
1464:
1456:
1452:
1448:
1447:was renamed
1444:
1440:
1432:
1423:
1417:
1406:
1383:
1378:
1363:
1353:Enterococcus
1351:
1325:
1306:
1301:
1298:
1268:heavy chain
1259:
1239:gangliosides
1212:
1206:
1198:
1172:
1157:
1147:
1143:
1141:
1122:
1118:heart attack
1112:can include
1110:
1103:
1099:
1096:Side effects
1086:chronic pain
1075:
1066:
1062:
1034:
1004:prophylactic
997:
985:
967:FDA approves
960:
953:
947:
931:anal fissure
888:
880:
877:Medical uses
844:
840:
810:
796:
792:
788:
787:
649:BRENDA entry
604:Bontoxilysin
589:
583:
287:Legal status
281:Legal status
245:subcutaneous
178:License data
39:
18:
14507:Neurotoxins
14182:Active site
14116:Lysostaphin
14101:Thermolysin
13963:Gelatinases
13696:Yves Rocher
13671:Urban Decay
13666:Uoma Beauty
13656:Ulta Beauty
13551:O Boticário
13436:Lise Watier
13353:Etude House
13278:Burt's Bees
13263:Bobbi Brown
13258:Bite Beauty
13159:Cosmetology
13077:Nail polish
12952:Conditioner
12916:Eyelid glue
12819:Moisturizer
12809:Highlighter
12498:Inhibitors:
12475:Coluracetam
12457:Inhibitors:
12427:Transporter
12367:Inhibitors:
12339:Pralidoxime
12233:Cyclanoline
12183:α-Viniferin
12080:Trichlorfon
11845:Metrifonate
11760:Fosthiazate
11745:Fluorotabun
11620:Dicrotophos
11575:Crotylsarin
11419:Huperzine A
11414:Galantamine
11409:Edrophonium
11342:Neostigmine
11337:Ganstigmine
11303:Propamocarb
11248:Formetanate
11233:Ethienocarb
11213:Carbosulfan
11203:Carbetamide
11198:Carbendazim
11169:Reversible:
11082:Inhibitors:
10915:Snake venom
10869:Epibatidine
10857:Cinobufagin
10714:Stromatoxin
10661:Imperatoxin
10611:Scyllatoxin
10517:Tagetitoxin
10512:Swainsonine
10502:Solauricine
10467:Solamargine
10462:Scopolamine
10452:Retronecine
10318:Zearalenone
9986:Shiga toxin
9957:Cord factor
9796:Enterotoxin
9791:Alpha toxin
9785:perfringens
9777:Tetanolysin
9755:Clostridium
9692:hepatotoxin
9682:enterotoxin
9672:cardiotoxin
9596:Tolperisone
9581:Silperisone
9571:Promoxolane
9531:Lanperisone
9526:Inaperisone
9511:Flopropione
9506:Fenyramidol
9395:Eszopiclone
9309:Meprobamate
9304:Febarbamate
9174:Pancuronium
9103:Gantacurium
9035:(primarily
8980:MedlinePlus
8968:MedlinePlus
8956:MedlinePlus
8944:MedlinePlus
8932:MedlinePlus
8747:NCT01917006
8695:5 September
8493:23 November
7661:BMC Biology
7343:22 November
7313:23 November
7283:18 December
7253:23 November
7223:18 December
5826:(10): 421.
5494:Mayo Clinic
5375:1 September
5342:18 December
5305:18 December
5275:18 December
5245:18 December
5142:23 November
4962:29 December
4880:(1): 8–14.
4469:: 223–228.
2833:18 December
2770:18 December
2740:18 December
2710:18 December
2680:18 December
2328:18 December
2297:5 September
2204:treatment.
2110:(LLS), the
1940:Clostridium
1876:indications
1799:Brand names
1771:pralidoxime
1511:August 2018
1457:Clostridium
1398:Württemberg
1328:neurotoxins
1326:Clostridium
1278:presynaptic
1272:joined via
1270:polypeptide
1231:endocytosis
1080:, and some
911:vocal cords
637:IntEnz view
609:Identifiers
577: g·mol
510:100.088.372
365:Identifiers
249:intradermal
164:MedlinePlus
88:Biosimilars
82:BoNT, botox
79:Other names
70:Trade names
14466:Categories
14385:Isomerases
14359:Hydrolases
14226:Regulation
14091:Neprilysin
13717:Categories
13616:SimplySiti
13611:Shu Uemura
13531:Neutrogena
13481:Maybelline
13476:Max Factor
13446:L'Occitane
13386:Hard Candy
13268:Bonne Bell
13098:Cold cream
12926:Eye shadow
12804:Foundation
12779:Cotton pad
12662:versutoxin
12658:robustoxin
12532:Inhibitors
12521:modulators
12472:Enhancers:
12433:modulators
12390:Ladostigil
12380:Conodurine
12375:Affinisine
12288:Ungeremine
12263:Phosacetim
12223:Corynoline
12218:Corydaline
12208:Conodurine
12193:Affinisine
12129:Demecarium
12127:; Others:
12040:Tabun (GA)
12030:Soman (GD)
12020:Sarin (GB)
11940:Profenofos
11800:Isoxathion
11785:Guanitoxin
11755:Formothion
11730:Fenamiphos
11660:Disulfoton
11655:Dioxathion
11645:Dimethoate
11615:Dichlorvos
11449:Ladostigil
11439:Ipidacrine
11384:Ambenonium
11379:Acotiamide
11377:; Others:
11350:Phenserine
11327:Distigmine
11318:Thiodicarb
11293:Pirimicarb
11258:Methiocarb
11243:Fenobucarb
11218:Chlorbufam
11208:Carbofuran
11183:Bendiocarb
11164:Inhibitors
11058:modulators
11044:modulators
11037:metabolism
10947:Taicatoxin
10884:Samandarin
10837:Bufotoxins
10801:Ciguatoxin
10779:Vertebrate
10724:Huwentoxin
10704:Cupiennins
10687:Latrotoxin
10631:Kaliotoxin
10601:Margatoxin
10591:Maurotoxin
10532:Toxalbumin
10522:Tinyatoxin
10507:Strychnine
10492:Solasonine
10487:Solasodine
10472:Solanidine
10392:Falcarinol
10377:Delphinine
10293:Phalloidin
10283:Ochratoxin
10278:Orellanine
10268:Lolitrem B
10235:Ergotamine
10185:Mycotoxins
10029:Mechanisms
9988:/Verotoxin
9925:Exfoliatin
9885:Leukocidin
9702:phototoxin
9697:neurotoxin
9623:Dantrolene
9591:Tizanidine
9561:Pregabalin
9546:Metaxalone
9536:Mephenesin
9516:Gabapentin
9377:Tetrazepam
9367:Nitrazepam
9352:Clonazepam
9342:Bromazepam
9164:Doxacurium
9154:Vecuronium
9149:Rocuronium
9144:Fazadinium
9134:Atracurium
9124:Chandonium
9119:Mivacurium
9072:Alcuronium
8916:A0A0X1KH89
8536:16 October
7707:"Botulism"
7499:9 December
7116:"M8 Paper"
7061:24 January
5504:1 November
4145:7 November
3849:(1): 1–5.
3690:14 October
3265:28 October
3230:28 October
3152:(1): 1–8.
2386:22 October
2260:References
2242:See also:
2228:depression
2220:See also:
2216:Depression
2193:See also:
2163:Sialorrhea
2158:Sialorrhea
2148:spasticity
2142:, loss of
2035:See also:
2012:inhibition
1844:April 2017
1722:Botox cost
1653:headache.
1567:strabismus
1561:Strabismus
1428:Ellezelles
1359:A0A069CUU9
1347:A0A242DI27
1336:family M27
1179:antibodies
1114:arrhythmia
949:Strabismus
935:refractory
895:spasticity
801:neurotoxic
706:structures
673:KEGG entry
566:Molar mass
463:0Y70779M1F
455:E211KPY694
429:ChemSpider
389:93384-43-2
381:93384-43-1
371:CAS Number
320:Schedule D
14497:EC 3.4.24
14264:EC number
13773:Proteases
13721:Companies
13661:Ultima II
13631:Skin Food
13581:Red Earth
13308:CoverGirl
12997:threading
12921:Eye liner
12774:Concealer
12740:Cosmetics
12644:agonists:
12628:Enhancers
12501:Vesamicol
12385:Cymserine
12334:Obidoxime
12329:Methoxime
12243:Harmaline
12238:Cymserine
12228:Crimidine
12175:Unsorted:
12070:Triazofos
12010:Ro 3-0433
12005:Ro 3-0422
12000:Ro 3-0419
11995:Ro 3-0417
11990:Ro 3-0412
11985:Ro 3-0411
11980:Ro 3-0397
11975:Ro 3-0352
11970:Ro 3-0351
11965:Ro 3-0347
11960:Ro 3-0346
11955:Ro 3-0340
11945:Prothoate
11915:Phosfolan
11910:Phosalone
11895:Parathion
11880:Omethoate
11850:Mevinphos
11815:Malathion
11805:Leptophos
11710:Endothion
11590:Demephion
11580:Cyanophos
11570:Coumaphos
11540:Cadusafos
11535:Bensulide
11530:BAY-29952
11494:Zanapezil
11454:Minaprine
11434:Huprine Y
11429:Huprine X
11424:Huprine W
11394:Donepezil
11323:Thiofanox
11298:Promecarb
11288:Pinmicarb
11268:Metolcarb
11228:Dimetilan
11188:Bufencarb
11178:Aminocarb
11130:CM-54,903
11041:transport
10852:Bufotenin
10847:Bufotalin
10817:Amphibian
10760:Saxitoxin
10750:Eledoisin
10745:Conotoxin
10616:Hefutoxin
10432:Oleandrin
10412:Linamarin
10402:Helenalin
10362:Cicutoxin
10357:Chaconine
10337:Amygdalin
10308:Vomitoxin
10258:Gliotoxin
10240:Fumonisin
10193:Aflatoxin
10156:Virulence
10092:Endotoxin
9823:botulinum
9804:difficile
9714:Bacterial
9687:hemotoxin
9677:cytotoxin
9501:Eperisone
9372:Temazepam
9362:Lorazepam
9319:Styramate
9196:unsorted:
9189:Gallamine
9184:Laudexium
9064:alkaloids
9042:NMJ block
9017:Skeletal
8176:167319134
8058:232058260
7725:28 August
7667:(1): 66.
7616:(1): 34.
6805:5 October
5971:Neurology
5725:Molecules
5474:5 October
5437:4 October
5132:0362-4331
4063:1 October
3775:245177279
3404:drugs.com
3124:232408799
2347:"Nuceiva"
2201:migraines
2084:glabellar
2004:denatured
1832:talk page
1731:Insurance
1714:US market
1662:Economics
1613:Cosmetics
1437:Darmstadt
1309:AB toxins
1235:cytoplasm
1175:antitoxin
1057:glabellar
1007:treatment
915:esophagus
808:bacterium
626:Databases
620:3.4.24.69
234:Routes of
208:Pregnancy
153:Monograph
145:Monograph
137:Monograph
129:Monograph
121:Monograph
113:Monograph
103:Drugs.com
14492:Botulism
14456:Medicine
14288:Kinetics
14212:Cofactor
14175:Activity
14126:ZMPSTE24
13928:ADAMTS13
13923:ADAMTS12
13918:ADAMTS10
13691:Younique
13676:Vaseline
13606:Shiseido
13561:Oriflame
13471:Mary Kay
13381:Guerlain
13328:Dermacol
13313:Creme 21
13293:Clinique
13253:Biotherm
13228:Artistry
13223:Aqua Net
13218:Anna Sui
13082:Pedicure
13072:Manicure
12987:plucking
12972:electric
12967:chemical
12865:Lipstick
12789:DD cream
12784:Cleanser
12769:CC cream
12759:BB cream
12684:See also
12668:Crotoxin
12370:Affinine
12303:BW284C51
12258:Lycorine
12188:Affinine
12178:α-Pinene
12156:Onchidal
12075:Tribufos
12055:Terbufos
12025:Schradan
11890:Paraoxon
11810:Malaoxon
11740:Fenthion
11725:Ethoprop
11610:Diazinon
11605:Dialifor
11510:Acephate
11444:Itopride
11389:Caffeine
11313:Propoxur
11263:Methomyl
11193:Carbaryl
11173:Aldicarb
10992:Category
10755:Onchidal
10735:Mollusca
10646:Bestoxin
10641:Birtoxin
10606:Slotoxin
10596:Agitoxin
10571:Scorpion
10527:Tomatine
10477:Solanine
10422:Mimosine
10397:Gossypol
10382:Divicine
10347:Antiarin
10342:Anisatin
10273:Muscimol
10225:Citrinin
10198:Amatoxin
10144:Cry34Ab1
10072:AB toxin
10066:type III
9978:negative
9736:positive
9725:Exotoxin
9566:Pridinol
9556:Phenibut
9481:Baclofen
9413:Etizolam
9347:Diazepam
9324:Tybamate
8850:34787840
8805:31609882
8732:24345483
8689:Archived
8668:24196194
8660:26441090
8625:32191932
8617:20425239
8574:20487038
8554:Headache
8530:Archived
8465:21242533
8424:21093661
8389:20529632
8354:19123705
8313:25654058
8256:Archived
8198:Archived
8194:Allergan
8101:29006338
8050:33632627
8015:25922620
7908:19327377
7851:17336071
7765:12 March
7756:Archived
7719:Archived
7693:19804621
7642:30641949
7583:Archived
7456:Archived
7438:24587850
7380:Archived
7376:Allergan
7337:Archived
7307:Archived
7277:Archived
7247:Archived
7123:Archived
7094:Archived
7055:Archived
7019:Medscape
6991:Archived
6958:Archived
6921:Archived
6897:13 March
6891:Archived
6861:Archived
6828:Archived
6758:24819339
6709:22535858
6674:24406607
6666:11112955
6593:14759577
6558:14504502
6482:20036435
6390:Archived
6362:27341687
6292:43093912
6284:14163805
6206:15394302
6157:21026141
6112:3 August
6106:Archived
6088:22651975
6053:28388718
5999:46559225
5991:10563638
5945:15027048
5903:29323697
5852:30347838
5798:23239346
5757:21193845
5697:30388027
5645:16307223
5637:15830090
5593:16318699
5541:24106296
5498:Archived
5468:Archived
5431:Archived
5409:Archived
5405:CBC News
5336:Archived
5209:Archived
5136:Archived
5103:24003345
5062:33603602
5013:33603602
4956:Archived
4952:16112345
4906:20418969
4852:20824874
4821:15598005
4780:41120474
4772:26866499
4735:30 April
4729:Archived
4691:23 March
4685:Archived
4640:Archived
4610:23 March
4604:Archived
4557:Archived
4531:25077722
4495:31114283
4442:27 April
4433:Archived
4431:. 2011.
4400:Archived
4378:15887434
4326:Archived
4322:Medscape
4300:22877654
4251:24857218
4243:28623614
4208:26924985
4139:Archived
4115:16 March
4109:Archived
4084:Archived
4057:Archived
3991:22161392
3960:21412485
3911:21782318
3875:22251031
3824:23503707
3767:17122031
3733:19952618
3684:Archived
3666:30423587
3617:17607049
3568:11209178
3533:21149997
3492:31111466
3449:23 March
3443:Archived
3408:Archived
3385:31591703
3329:32224633
3259:Archived
3224:Archived
3203:32387953
3195:16417591
3116:33776040
3070:15839401
3030:46981635
3022:11893235
2987:15907915
2931:Archived
2927:DailyMed
2892:Archived
2888:DailyMed
2862:Archived
2858:DailyMed
2827:Archived
2823:DailyMed
2797:Archived
2793:DailyMed
2764:Archived
2734:Archived
2704:Archived
2674:Archived
2644:Archived
2612:Archived
2556:Archived
2526:Archived
2502:31 March
2496:Archived
2476:10 April
2470:Archived
2440:Archived
2410:Archived
2322:Archived
2291:DailyMed
2256:trials.
2254:Phase II
2209:migraine
2183:dystonia
2140:weakness
2136:lengthen
2069:Cosmetic
2026:Research
1948:botulism
1881:Galderma
1826:You may
1767:atropine
1748:Cosmetic
1651:migraine
1453:Bacillus
1418:In 1895
1407:botulism
1223:takes up
1138:Botulism
1053:Daewoong
1045:Galderma
1041:Allergan
1037:wrinkles
1017:headache
1014:migraine
994:Migraine
836:botulism
777:proteins
765:articles
753:articles
710:RCSB PDB
592:(verify)
400:DrugBank
256:ATC code
223: B3
210:category
192:DailyMed
14444:Biology
14430:Portals
14398:Ligases
14168:Enzymes
13913:ADAMTS9
13908:ADAMTS8
13903:ADAMTS5
13898:ADAMTS4
13893:ADAMTS3
13888:ADAMTS2
13883:ADAMTS1
13731:History
13601:Sephora
13566:Origins
13441:L'Oréal
13426:Laneige
13421:Lancôme
13411:Kiehl's
13376:Garnier
13358:Fabergé
13333:Douglas
13288:Clarins
13248:Benefit
13132:Related
13108:Peeling
13067:Buffing
13014:Sindoor
13009:Shampoo
12992:shaving
12962:Removal
12936:Mascara
12654:Others:
12606:Others:
12542:SNAP-25
12515:Release
12405:Tacrine
12313:3152 CT
12278:Taspine
12050:Temefos
11950:R-16661
11920:Phosmet
11905:Phorate
11855:Mipafox
11820:Mazidox
11750:Fonofos
11695:EA-4352
11690:EA-3148
11685:EA-2613
11680:EA-2192
11675:EA-2098
11670:EA-2054
11665:EA-2012
11640:Dimefox
11595:Demeton
11489:Tacrine
11484:TL-1238
11404:EA-4056
11399:EA-3990
11308:Propham
11273:Miotine
10910:Reptile
10372:Daphnin
10367:Coniine
10352:Brucine
10313:Zeranol
10288:Patulin
10135:toxins
10125:Cry3Bb1
10105:Lipid A
10052:type II
9993:E. coli
9745:Bacilli
9576:Quinine
8921:PDBe-KB
8911:UniProt
8900:PDBe-KB
8890:UniProt
8879:PDBe-KB
8869:UniProt
8841:8648634
8796:6940025
8718:: 1–6.
8582:9621285
8304:4316364
8262:26 June
8230:26 June
8204:1 March
8129:26 July
8117:. U.S.
8093:7995530
8006:4356659
7966:2779991
7935:3607594
7899:2730986
7878:Bibcode
7870:Toxicon
7816:5339838
7684:2764570
7633:6357194
7550:1579114
7462:14 July
7429:3935649
7331:. U.S.
7301:. U.S.
7241:. U.S.
7211:. U.S.
7100:10 June
7030:14 July
6956:(FDA).
6952:. U.S.
6749:4241086
6631:1740562
6520:2748749
6435:26 July
6420:. U.S.
6396:14 July
6354:7243198
6319:4203467
6264:Bibcode
6256:Science
6241:7099568
6197:1392572
6137:Bibcode
6129:Science
6044:5434488
5953:8190807
5894:5838542
5843:6215321
5748:6259422
5688:7539302
5584:3366733
5466:(CDC).
5462:. U.S.
5429:(CDC).
5425:. U.S.
5363:. U.S.
5330:. U.S.
5293:. U.S.
5263:. U.S.
5215:16 July
5160:. U.S.
5094:3760599
5053:7874868
5004:7874868
4897:2856357
4486:6489637
4332:6 April
4291:3538391
4199:4759702
4137:(FDA).
4133:. U.S.
4026:8014792
3951:3048443
3866:9374973
3815:3589133
3657:6243868
3608:1905930
3524:3028942
3414:4 March
3376:6779591
3320:7161716
3078:2855356
2898:12 June
2868:12 June
2803:12 June
2650:7 April
2618:2 April
2588:1 April
2562:11 June
2532:12 June
2446:8 April
2416:8 April
2357:8 April
2118:(ZMi).
2104:gingiva
1903:namely
1681:updated
1591:albumin
1412:botulus
1386:Wildbad
1372:History
1302:in vivo
1286:SNAP-25
1262:protein
1227:vesicle
1215:neurons
1082:allergy
1011:chronic
927:bladder
865:, 10–13
804:protein
732:QuickGO
697:profile
680:MetaCyc
527:Formula
418:DB00042
410:DB00083
348:Rx-only
345:WARNING
316: /
312::
273:)
267: (
265:M03AX01
194::
170:a619021
14372:Lyases
14050:MMP23B
14045:MMP23A
13878:ADAM33
13873:ADAM28
13868:ADAM23
13863:ADAM22
13858:ADAM18
13853:ADAM15
13848:ADAM12
13843:ADAM11
13821:ADAM19
13816:ADAM17
13811:ADAM10
13784:3.4.24
13726:People
13596:Rimmel
13586:Revlon
13576:Pond's
13536:Nexxus
13511:Natura
13491:Missha
13363:Farmec
13103:Lotion
13034:pomade
13029:mousse
13002:waxing
12834:Powder
12829:Primer
12794:Facial
12015:Ronnel
11930:Phoxim
11720:Ethion
11515:Armine
11479:TL-599
11474:T-1194
11469:T-1152
11464:T-1123
11278:Oxamyl
11052:Enzyme
10782:toxins
10677:Spider
10651:BmKAEP
10621:HgeTx1
10562:toxins
10437:Persin
10330:toxins
10158:factor
10139:Cry6Aa
10131:Other
10120:Cry1Ac
10038:type I
9841:Other:
9766:tetani
9716:toxins
9667:Toxins
9282:esters
9061:Curare
8895:P10844
8874:P0DPI1
8848:
8838:
8803:
8793:
8730:
8666:
8658:
8623:
8615:
8580:
8572:
8463:
8422:
8387:
8352:
8311:
8301:
8174:
8099:
8091:
8056:
8048:
8013:
8003:
7964:
7933:
7906:
7896:
7849:
7814:
7807:546888
7804:
7691:
7681:
7640:
7630:
7610:Toxins
7589:13 May
7548:
7541:372855
7538:
7436:
7426:
7191:
7158:
7086:
6997:22 May
6967:22 May
6927:22 May
6867:22 May
6837:22 May
6756:
6746:
6707:
6672:
6664:
6629:
6591:
6556:
6518:
6480:
6360:
6352:
6317:
6290:
6282:
6239:
6204:
6194:
6155:
6086:
6051:
6041:
5997:
5989:
5951:
5943:
5901:
5891:
5850:
5840:
5820:Toxins
5796:
5786:
5755:
5745:
5695:
5685:
5643:
5635:
5591:
5581:
5539:
5130:
5101:
5091:
5060:
5050:
5011:
5001:
4950:
4904:
4894:
4850:
4819:
4778:
4770:
4563:9 July
4529:
4493:
4483:
4406:12 May
4376:
4298:
4288:
4249:
4241:
4206:
4196:
4182:: 29.
4049:
4024:
3989:
3958:
3948:
3909:
3873:
3863:
3822:
3812:
3773:
3765:
3731:
3664:
3654:
3615:
3605:
3566:
3531:
3521:
3490:
3383:
3373:
3327:
3317:
3255:CIDRAP
3201:
3193:
3122:
3114:
3076:
3068:
3028:
3020:
2985:
1341:P0DPK1
1332:MEROPS
1290:fusion
1201:) and
1168:stroke
1166:, and
907:vagina
903:eyelid
899:spasms
871:
867:
852:
760:PubMed
742:Search
728:AmiGO
716:PDBsum
656:ExPASy
644:BRENDA
632:IntEnz
615:EC no.
492:D08957
484:D00783
342:
329:
318:
314:℞-only
300:
190:
52:entry
45:P0DPI1
14324:Types
14084:Other
14075:MMP28
14070:MMP27
14065:MMP26
14060:MMP25
14055:MMP24
14040:MMP21
14035:MMP20
14030:MMP19
14025:MMP17
14020:MMP16
14015:MMP15
14010:MMP14
14005:MMP13
14000:MMP12
13995:MMP11
13990:MMP10
13838:ADAM8
13833:ADAM7
13828:ADAM2
13806:ADAM9
13686:Wella
13636:Stila
13626:SK-II
13541:Nivea
13372:Fresh
13318:Cutex
13233:Aveda
13203:Almay
13198:Ahava
13055:Nails
13039:spray
12977:laser
12885:Stain
12880:Liner
12875:Gloss
12844:Toner
12839:Rouge
12486:VAChT
12308:TMTFA
11870:Naled
11775:GT-45
11765:GD-42
11115:AF64A
10709:PhTx3
10626:HsTx1
10549:Tutin
10542:Ricin
10537:Abrin
10407:Ledol
10328:Plant
9920:delta
9868:Cocci
9829:Botox
9469:Other
8818:Drugs
8664:S2CID
8621:S2CID
8578:S2CID
8172:S2CID
8097:S2CID
8054:S2CID
7759:(PDF)
7752:(FDA)
7748:U.S.
7744:(PDF)
7715:(CDC)
7711:U.S.
7579:(CDC)
7575:U.S.
7493:(PDF)
7482:(PDF)
7389:3 May
7383:(PDF)
7372:(PDF)
7273:Hugel
7126:(PDF)
7119:(PDF)
6961:(PDF)
6946:(PDF)
6831:(PDF)
6824:(PDF)
6670:S2CID
6429:(PDF)
6418:(PDF)
6358:S2CID
6288:S2CID
5995:S2CID
5949:S2CID
5641:S2CID
5172:6 May
4776:S2CID
4725:(FDA)
4721:U.S.
4681:(FDA)
4677:U.S.
4600:(FDA)
4596:U.S.
4436:(PDF)
4425:(PDF)
4396:WebMD
4247:S2CID
3771:S2CID
3199:S2CID
3120:S2CID
3074:S2CID
3026:S2CID
3002:Drugs
2760:(emc)
2730:(emc)
2700:(emc)
2670:(emc)
2100:gummy
1834:, or
1072:Other
1049:Ipsen
822:from
797:botox
791:, or
692:PRIAM
541:10447
14416:list
14409:EC7
14403:list
14396:EC6
14390:list
14383:EC5
14377:list
14370:EC4
14364:list
14357:EC3
14351:list
14344:EC2
14338:list
14331:EC1
13985:MMP7
13980:MMP3
13973:MMP9
13968:MMP2
13956:MMP8
13951:MMP1
13506:NARS
13456:Lush
13298:Coty
13238:Avon
13091:Body
12945:Hair
12931:Kohl
12894:Eyes
12870:Balm
12858:Lips
12747:Face
12638:LPHN
12573:VAMP
12355:BChE
11865:MSPI
11151:AChE
11125:BETA
11120:B115
11070:ChAT
11039:and
10791:Fish
10699:CSTX
9976:Gram
9916:beta
9734:Gram
8909:for
8888:for
8867:for
8846:PMID
8801:PMID
8728:PMID
8697:2017
8656:PMID
8613:PMID
8570:PMID
8538:2010
8495:2019
8461:PMID
8420:PMID
8385:PMID
8350:PMID
8309:PMID
8264:2011
8232:2011
8206:2018
8131:2010
8089:PMID
8046:PMID
8011:PMID
7962:PMID
7931:PMID
7904:PMID
7847:PMID
7812:PMID
7767:2023
7727:2019
7689:PMID
7638:PMID
7591:2020
7546:PMID
7501:2009
7464:2010
7434:PMID
7391:2012
7345:2019
7315:2019
7285:2022
7255:2019
7225:2022
7189:ISBN
7156:ISBN
7134:2020
7102:2022
7084:ISBN
7063:2022
7032:2010
6999:2021
6969:2021
6929:2021
6899:2013
6869:2021
6839:2021
6807:2012
6754:PMID
6705:PMID
6689:JAMA
6662:PMID
6627:PMID
6589:PMID
6554:PMID
6516:PMID
6478:PMID
6437:2010
6398:2010
6350:PMID
6315:PMID
6280:PMID
6237:PMID
6202:PMID
6153:PMID
6114:2022
6084:PMID
6049:PMID
5987:PMID
5941:PMID
5899:PMID
5848:PMID
5794:PMID
5784:ISBN
5753:PMID
5693:PMID
5633:PMID
5589:PMID
5537:PMID
5506:2023
5476:2016
5439:2016
5377:2015
5344:2022
5307:2022
5277:2022
5247:2022
5217:2019
5174:2012
5144:2021
5128:ISSN
5099:PMID
5058:PMID
5009:PMID
4964:2021
4948:PMID
4902:PMID
4848:PMID
4817:PMID
4768:PMID
4737:2024
4693:2024
4648:2022
4612:2024
4565:2019
4527:PMID
4491:PMID
4444:2024
4408:2017
4374:PMID
4334:2014
4296:PMID
4239:PMID
4204:PMID
4147:2016
4117:2020
4065:2020
4047:ISBN
4022:PMID
3987:PMID
3956:PMID
3907:PMID
3871:PMID
3820:PMID
3763:PMID
3729:PMID
3692:2015
3662:PMID
3613:PMID
3564:PMID
3548:JAMA
3529:PMID
3488:PMID
3451:2019
3416:2015
3381:PMID
3359:2019
3325:PMID
3267:2019
3232:2019
3191:PMID
3112:PMID
3066:PMID
3018:PMID
2983:PMID
2939:2022
2900:2022
2870:2022
2835:2022
2805:2022
2772:2022
2742:2022
2712:2022
2682:2022
2652:2024
2620:2024
2590:2024
2564:2022
2534:2022
2504:2024
2478:2023
2448:2023
2418:2023
2388:2023
2359:2023
2330:2022
2299:2024
2093:LD50
1919:and
1889:Merz
1769:and
1245:and
1207:TeNT
1199:BoNT
1047:and
925:and
857:/kg
824:axon
772:NCBI
713:PDBe
668:KEGG
553:2010
547:1743
535:6760
474:KEGG
445:UNII
99:AHFS
55:3BTA
40:BotA
13556:OPI
13348:elf
13044:wax
13024:gel
12982:IPL
12445:CHT
11715:EPN
10666:Pi3
10636:Lq2
10076:AB5
9521:GHB
9023:M03
8907:PDB
8886:PDB
8865:PDB
8836:PMC
8826:doi
8791:PMC
8781:doi
8777:145
8720:doi
8648:doi
8644:136
8605:doi
8562:doi
8525:CNN
8451:doi
8447:137
8412:doi
8377:doi
8340:doi
8299:PMC
8291:doi
8164:doi
8081:doi
8038:doi
8001:PMC
7993:doi
7954:doi
7894:PMC
7886:doi
7839:doi
7802:PMC
7794:doi
7679:PMC
7669:doi
7628:PMC
7618:doi
7536:PMC
7528:doi
7424:PMC
7181:doi
6744:PMC
6736:doi
6732:171
6697:doi
6693:307
6654:doi
6650:123
6619:doi
6581:doi
6546:doi
6542:112
6508:doi
6470:doi
6342:doi
6272:doi
6260:145
6229:doi
6192:PMC
6184:doi
6180:109
6145:doi
6133:103
6076:doi
6039:PMC
6031:doi
5979:doi
5933:doi
5889:PMC
5879:doi
5875:592
5838:PMC
5828:doi
5776:doi
5743:PMC
5733:doi
5683:PMC
5675:doi
5623:doi
5579:PMC
5571:doi
5529:doi
5525:209
5089:PMC
5048:PMC
5040:doi
4999:PMC
4991:doi
4940:doi
4892:PMC
4882:doi
4840:doi
4807:doi
4760:doi
4481:PMC
4471:doi
4364:doi
4286:PMC
4278:doi
4231:doi
4194:PMC
4184:doi
4014:doi
3979:doi
3946:PMC
3938:doi
3899:doi
3861:PMC
3851:doi
3810:PMC
3802:doi
3759:106
3719:doi
3715:124
3652:PMC
3644:doi
3603:PMC
3595:doi
3556:doi
3552:285
3519:PMC
3515:132
3478:doi
3474:593
3371:PMC
3363:doi
3315:PMC
3305:doi
3183:doi
3154:doi
3104:doi
3100:147
3058:doi
3010:doi
2975:doi
2381:FDA
2014:by
1979:.
1775:NBC
1501:by
1334:as
1266:kDa
1247:SV2
1009:of
919:jaw
861:or
748:PMC
704:PDB
575:.05
573:323
571:149
331:POM
270:WHO
50:PDB
48:).
14468::
13781:EC
13775::
12660:,
12615:,
12596:,
12592:,
12588:,
12561:,
12557:,
12322::
12148:,
12144:,
12140:,
12125:VX
12120:VR
12115:VS
12110:VP
12105:VM
12100:VG
12095:VE
11780:GV
11770:GH
10246:,
10212:,
10208:,
10204:,
9112::
8978:.
8966:.
8954:.
8942:.
8930:.
8913::
8892::
8871::
8844:.
8834:.
8822:81
8820:.
8816:.
8799:.
8789:.
8775:.
8771:.
8726:.
8716:52
8714:.
8687:.
8676:^
8662:.
8654:.
8642:.
8619:.
8611:.
8601:10
8599:.
8576:.
8568:.
8558:50
8556:.
8528:.
8522:.
8459:.
8445:.
8441:.
8418:.
8408:63
8406:.
8383:.
8373:11
8371:.
8348:.
8336:79
8334:.
8330:.
8307:.
8297:.
8285:.
8281:.
8248:.
8192:.
8170:.
8160:76
8158:.
8095:.
8087:.
8077:10
8075:.
8052:.
8044:.
8034:44
8032:.
8009:.
7999:.
7987:.
7983:.
7960:.
7927:22
7925:.
7902:.
7892:.
7884:.
7874:54
7872:.
7868:.
7845:.
7835:15
7833:.
7810:.
7800:.
7790:15
7788:.
7784:.
7746:.
7709:.
7687:.
7677:.
7663:.
7659:.
7636:.
7626:.
7614:11
7612:.
7608:.
7573:.
7558:^
7544:.
7534:.
7524:56
7522:.
7518:.
7484:.
7432:.
7418:.
7414:.
7400:^
7378:.
7374:.
7271:.
7187:.
7136:.
7092:.
7053:.
7016:.
6989:.
6985:.
6948:.
6915:.
6889:.
6885:.
6859:.
6855:.
6774:.
6752:.
6742:.
6730:.
6726:.
6703:.
6691:.
6668:.
6660:.
6648:.
6625:.
6615:18
6613:.
6601:^
6587:.
6577:21
6575:.
6552:.
6540:.
6528:^
6514:.
6504:84
6502:.
6490:^
6476:.
6466:95
6464:.
6406:^
6388:.
6382:.
6370:^
6356:.
6348:.
6338:87
6336:.
6311:12
6309:.
6286:.
6278:.
6270:.
6258:.
6235:.
6225:89
6223:.
6200:.
6190:.
6178:.
6174:.
6151:.
6143:.
6131:.
6082:.
6072:15
6070:.
6047:.
6037:.
6027:37
6025:.
6021:.
6007:^
5993:.
5985:.
5975:53
5973:.
5961:^
5947:.
5939:.
5929:19
5927:.
5911:^
5897:.
5887:.
5873:.
5869:.
5846:.
5836:.
5824:10
5822:.
5818:.
5806:^
5792:.
5782:.
5751:.
5741:.
5729:16
5727:.
5723:.
5705:^
5691:.
5681:.
5671:88
5669:.
5665:.
5653:^
5639:.
5631:.
5619:63
5617:.
5613:.
5601:^
5587:.
5577:.
5567:11
5565:.
5561:.
5549:^
5535:.
5523:.
5496:.
5492:.
5447:^
5403:.
5352:^
5315:^
5203:.
5192:^
5134:.
5126:.
5122:.
5097:.
5083:.
5079:.
5056:.
5046:.
5036:37
5034:.
5030:.
5007:.
4997:.
4987:37
4985:.
4981:.
4954:.
4946:.
4936:53
4934:.
4930:.
4914:^
4900:.
4890:.
4878:55
4876:.
4872:.
4860:^
4846:.
4815:.
4803:61
4801:.
4797:.
4774:.
4766:.
4756:36
4754:.
4719:.
4675:.
4656:^
4594:.
4573:^
4555:.
4551:.
4539:^
4523:90
4521:.
4503:^
4489:.
4479:.
4467:12
4465:.
4461:.
4427:.
4398:.
4394:.
4372:.
4360:80
4358:.
4354:.
4342:^
4324:.
4320:.
4308:^
4294:.
4284:.
4274:87
4272:.
4268:.
4245:.
4237:.
4227:19
4225:.
4202:.
4192:.
4178:.
4174:.
4107:.
4103:.
4073:^
4055:.
4020:.
4010:31
4008:.
3985:.
3954:.
3944:.
3934:11
3932:.
3928:.
3905:.
3895:60
3893:.
3869:.
3859:.
3847:62
3845:.
3841:.
3818:.
3808:.
3796:.
3792:.
3769:.
3757:.
3741:^
3727:.
3713:.
3709:.
3660:.
3650:.
3640:24
3638:.
3634:.
3611:.
3601:.
3589:.
3585:.
3562:.
3550:.
3527:.
3513:.
3509:.
3486:.
3472:.
3468:.
3437:.
3424:^
3406:.
3402:.
3379:.
3369:.
3357:.
3353:.
3337:^
3323:.
3313:.
3299:.
3295:.
3275:^
3253:.
3240:^
3211:^
3197:.
3189:.
3179:13
3177:.
3150:19
3148:.
3144:.
3132:^
3118:.
3110:.
3098:.
3086:^
3072:.
3064:.
3054:31
3052:.
3038:^
3024:.
3016:.
3006:62
3004:.
2981:.
2969:.
2947:^
2925:.
2908:^
2886:.
2856:.
2843:^
2821:.
2791:.
2780:^
2758:.
2728:.
2698:.
2668:.
2636:.
2606:.
2580:.
2550:.
2520:.
2494:.
2464:.
2434:.
2404:.
2379:.
2375:.
2349:.
2338:^
2320:.
2307:^
2289:.
2268:^
2234:.
2022:.
1913:,
1907:,
1780:50
1706:.
1609:.
1368:.
1315:,
1257:.
1241:,
1162:,
1116:,
978:.
940:.
921:,
917:,
905:,
855:ng
730:/
559:32
353:EU
338:US
325:UK
309:CA
302:S4
296:AU
247:,
243:,
219:AU
187:US
14432::
14418:)
14414:(
14405:)
14401:(
14392:)
14388:(
14379:)
14375:(
14366:)
14362:(
14353:)
14349:(
14340:)
14336:(
14160:e
14153:t
14146:v
13786:)
13779:(
13765:e
13758:t
13751:v
12732:e
12725:t
12718:v
12664:)
12619:)
12611:(
12600:)
12598:G
12594:F
12590:D
12586:B
12584:(
12565:)
12563:E
12559:C
12555:A
12553:(
12523:)
12519:(
12435:)
12431:(
12164:)
12158:(
12152:)
12150:4
12146:3
12142:2
12138:1
12136:(
11166::
11060:)
11056:(
11026:e
11019:t
11012:v
10917::
10912:/
10819::
10793::
10737::
10679::
10573::
10254:)
10242:(
10216:)
10200:(
10074:/
10002:/
9918:/
9914:/
9815:B
9810:A
9757::
9657:e
9650:t
9643:v
9448:)
9444:(
9225::
9044:)
9039:,
9025:)
9021:(
9010:e
9003:t
8996:v
8982:.
8970:.
8958:.
8946:.
8934:.
8923:.
8902:.
8881:.
8852:.
8828::
8807:.
8783::
8734:.
8722::
8699:.
8670:.
8650::
8627:.
8607::
8584:.
8564::
8540:.
8508:.
8497:.
8467:.
8453::
8426:.
8414::
8391:.
8379::
8356:.
8342::
8315:.
8293::
8287:8
8266:.
8234:.
8208:.
8178:.
8166::
8144:.
8133:.
8103:.
8083::
8060:.
8040::
8017:.
7995::
7989:8
7968:.
7956::
7937:.
7910:.
7888::
7880::
7853:.
7841::
7818:.
7796::
7769:.
7729:.
7695:.
7671::
7665:7
7644:.
7620::
7593:.
7552:.
7530::
7503:.
7466:.
7440:.
7420:7
7393:.
7358:.
7347:.
7317:.
7257:.
7227:.
7197:.
7183::
7164:.
7104:.
7065:.
7051:"
7034:.
7001:.
6971:.
6931:.
6901:.
6871:.
6841:.
6809:.
6760:.
6738::
6711:.
6699::
6676:.
6656::
6633:.
6621::
6595:.
6583::
6560:.
6548::
6522:.
6510::
6484:.
6472::
6450:.
6439:.
6400:.
6364:.
6344::
6321:.
6294:.
6274::
6266::
6243:.
6231::
6208:.
6186::
6159:.
6147::
6139::
6116:.
6090:.
6078::
6055:.
6033::
6001:.
5981::
5955:.
5935::
5905:.
5881::
5854:.
5830::
5800:.
5778::
5759:.
5735::
5699:.
5677::
5647:.
5625::
5595:.
5573::
5543:.
5531::
5508:.
5478:.
5441:.
5390:.
5379:.
5346:.
5309:.
5279:.
5249:.
5219:.
5187:.
5176:.
5146:.
5105:.
5085:6
5064:.
5042::
5015:.
4993::
4966:.
4942::
4908:.
4884::
4854:.
4842::
4823:.
4809::
4782:.
4762::
4739:.
4706:.
4695:.
4625:.
4614:.
4567:.
4533:.
4497:.
4473::
4446:.
4410:.
4380:.
4366::
4336:.
4302:.
4280::
4253:.
4233::
4210:.
4186::
4180:7
4160:.
4149:.
4119:.
4067:.
4028:.
4016::
3993:.
3981::
3962:.
3940::
3913:.
3901::
3877:.
3853::
3826:.
3804::
3798:6
3777:.
3735:.
3721::
3694:.
3668:.
3646::
3619:.
3597::
3591:5
3570:.
3558::
3535:.
3494:.
3480::
3453:.
3418:.
3387:.
3365::
3331:.
3307::
3301:8
3269:.
3234:.
3205:.
3185::
3162:.
3156::
3126:.
3106::
3080:.
3060::
3032:.
3012::
2989:.
2977::
2971:5
2941:.
2902:.
2872:.
2837:.
2807:.
2774:.
2744:.
2714:.
2684:.
2654:.
2622:.
2592:.
2566:.
2536:.
2506:.
2480:.
2450:.
2420:.
2390:.
2361:.
2332:.
2301:.
1986:)
1982:(
1924:,
1857:)
1851:(
1846:)
1842:(
1824:.
1693:)
1689:(
1683:.
1524:)
1518:(
1513:)
1509:(
1495:.
1205:(
556:S
550:O
544:N
538:H
532:C
355::
340::
327::
298::
221::
101:/
58:.
42:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.