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Broad-spectrum antiviral drug

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49:) or by targeting host cell factors and processes exploited by different viruses during infection. As of 2021, there are 150 known BSAs in varying stages of development, effective against 78 human viruses. BSAs are potential candidates for treatment of 37:, which inhibit the infection of multiple viruses from the same (intra-family BSAs) or different (inter-family BSAs) virus families. BSAs could be divided into experimental and investigational agents, and approved drugs. BSAs work by inhibiting 17: 74: 95: 90: 237:
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjørås M, et al. (April 2020).
294: 65:. Many BSAs show antiviral activity against other viruses than originally investigated (such as 8: 77:
is currently underway. A database of BSAs and viruses they inhibit could be found here (
265: 238: 214: 189: 141: 116: 270: 219: 146: 299: 260: 250: 209: 205: 201: 136: 128: 70: 255: 50: 288: 58: 38: 132: 274: 223: 150: 239:"Discovery and development of safe-in-man broad-spectrum antiviral agents" 34: 66: 62: 54: 42: 236: 46: 190:"Drug repurposing for new, efficient, broad spectrum antivirals" 187: 164: 78: 188:
García-Serradilla M, Risco C, Pacheco B (April 2019).
117:"Infectious disease. Combating emerging viral threats" 181: 286: 114: 243:International Journal of Infectious Diseases 264: 254: 213: 140: 14: 287: 24: 115:Bekerman E, Einav S (April 2015). 25: 311: 230: 51:emerging and re-emerging viruses 31:Broad-spectrum antivirals (BSAs) 75:drug repurposing for SARS-CoV-2 206:10.1016/j.virusres.2019.02.011 157: 108: 13: 1: 101: 33:are a class of molecules or 7: 84: 10: 316: 256:10.1016/j.ijid.2020.02.018 96:Broad-spectrum therapeutic 91:Broad-spectrum antibiotic 27:Class of antiviral drugs 18:Broad-spectrum antiviral 133:10.1126/science.aaa3778 79:https://drugvirus.info/ 16:(Redirected from 307: 279: 278: 268: 258: 234: 228: 227: 217: 185: 179: 178: 176: 175: 165:"DrugVirus.info" 161: 155: 154: 144: 112: 21: 315: 314: 310: 309: 308: 306: 305: 304: 295:Antiviral drugs 285: 284: 283: 282: 235: 231: 186: 182: 173: 171: 163: 162: 158: 127:(6232): 282–3. 113: 109: 104: 87: 71:interferon alfa 28: 23: 22: 15: 12: 11: 5: 313: 303: 302: 297: 281: 280: 229: 194:Virus Research 180: 169:drugvirus.info 156: 106: 105: 103: 100: 99: 98: 93: 86: 83: 73:). Efforts in 39:viral proteins 26: 9: 6: 4: 3: 2: 312: 301: 298: 296: 293: 292: 290: 276: 272: 267: 262: 257: 252: 248: 244: 240: 233: 225: 221: 216: 211: 207: 203: 199: 195: 191: 184: 170: 166: 160: 152: 148: 143: 138: 134: 130: 126: 122: 118: 111: 107: 97: 94: 92: 89: 88: 82: 80: 76: 72: 68: 64: 60: 56: 52: 48: 44: 40: 36: 32: 19: 246: 242: 232: 197: 193: 183: 172:. Retrieved 168: 159: 124: 120: 110: 30: 29: 249:: 268–276. 43:polymerases 289:Categories 174:2020-03-28 102:References 67:remdesivir 63:SARS-CoV-2 53:, such as 200:: 22–31. 47:proteases 41:(such as 35:compounds 275:32081774 224:30794895 151:25883340 85:See also 300:Viruses 266:7128205 215:7114681 142:4419706 121:Science 59:marburg 273:  263:  222:  212:  149:  139:  61:, and 55:ebola 271:PMID 220:PMID 147:PMID 69:and 45:and 261:PMC 251:doi 210:PMC 202:doi 198:264 137:PMC 129:doi 125:348 81:). 291:: 269:. 259:. 247:93 245:. 241:. 218:. 208:. 196:. 192:. 167:. 145:. 135:. 123:. 119:. 57:, 277:. 253:: 226:. 204:: 177:. 153:. 131:: 20:)

Index

Broad-spectrum antiviral
compounds
viral proteins
polymerases
proteases
emerging and re-emerging viruses
ebola
marburg
SARS-CoV-2
remdesivir
interferon alfa
drug repurposing for SARS-CoV-2
https://drugvirus.info/
Broad-spectrum antibiotic
Broad-spectrum therapeutic
"Infectious disease. Combating emerging viral threats"
doi
10.1126/science.aaa3778
PMC
4419706
PMID
25883340
"DrugVirus.info"
"Drug repurposing for new, efficient, broad spectrum antivirals"
doi
10.1016/j.virusres.2019.02.011
PMC
7114681
PMID
30794895

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