320:
297:
219:
194:
585:
571:
3941:
578:
3971:
1431:; however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. Splice variants of CD44 on colon cancer cells display sialofucosylated HCELL glycoforms that serve as P-, L-, and E-selectin ligands and fibrin, but not fibrinogen, receptors under hemodynamic flow conditions pertinent to the process of cancer metastasis.
326:
225:
31:
3956:
1663:
In other cases different research groups analyzing the same neoplastic disease reached contradictory conclusions regarding the correlation between CD44 expression and disease prognosis, possibly due to differences in methodology. These problems must be resolved before applying anti-CD44 therapy to
57:
1416:(MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below)
1510:. In breast cancer research CD44+/CD24- expression is commonly used as a marker for breast CSCs and is used to sort breast cancer cells into a population enriched in cells with stem-like characteristics and has been seen as an indicator of increased survival time in
3062:"Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression"
1647:
CD44v5 (includes the fifth 'v5' exon) is associated with better prognosis (increased time to recurrence following surgery). In prostate cancer, the exclusion of the v5 exon through alternative splicing was associated with the presence of RNA binding protein
1462:
to bone marrow. Ex vivo glycan engineering of the surface of live cells has been used to enforce HCELL expression on any cell that expresses CD44. CD44 glycosylation also directly controls its binding capacity to fibrin and immobilized fibrinogen.
3154:"Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts"
333:
232:
2274:
Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, et al. (February 2008). "Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone".
3380:
Zohar R, Suzuki N, Suzuki K, Arora P, Glogauer M, McCulloch CA, et al. (July 2000). "Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration".
2149:
Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (April 2008). "The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion".
2612:"Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen)"
3257:"CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes"
3103:"Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering"
1624:
generate many different CD44 sequences, including, perhaps, tumor-specific sequences, the production of anti-CD44 tumor-specific agents may be a realistic therapeutic approach.
1454:
The HCELL glycoform was originally discovered on human hematopoietic stem cells and leukemic blasts, and was subsequently identified on cancer cells. HCELL functions as a "bone
2915:
Eibl RH, Pietsch T, Moll J, Skroch-Angel P, Heider KH, von Ammon K, et al. (December 1995). "Expression of variant CD44 epitopes in human astrocytic brain tumors".
2831:
Assimakopoulos D, Kolettas E, Patrikakos G, Evangelou A (October 2002). "The role of CD44 in the development and prognosis of head and neck squamous cell carcinomas".
2465:"Selectin ligand expression regulates the initial vascular interactions of colon carcinoma cells: the roles of CD44v and alternative sialofucosylated selectin ligands"
4872:
2236:
Sackstein R, Dimitroff CJ (October 2000). "A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity".
2735:"Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants"
1597:. All these biological properties are essential to the physiological activities of normal cells, but they are also associated with the pathologic activities of
4011:
1855:"The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene"
2868:"High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event"
968:
949:
155:
6048:
3425:"CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration"
3011:"The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing"
4862:
3940:
1635:
are exceptions), a high level of CD44 expression is not always associated with an unfavorable outcome. On the contrary, in some neoplasms CD44
3989:
3860:
1835:
1817:
3869:
2509:"Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow"
54:
3970:
4842:
3393:
1271:
1264:
5704:
4028:
4004:
3880:
3296:
Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B (June 1990). "CD44 is the principal cell surface receptor for hyaluronate".
1943:
Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B (June 1990). "CD44 is the principal cell surface receptor for hyaluronate".
6197:
6599:
5435:
1494:
CD44 expression is an indicative marker for effector-memory T-cells. Memory cell proliferation (activation) can also be assayed
5423:
5201:
7144:
6041:
5487:
5482:
5428:
5208:
3920:
3873:
3695:
1499:
1800:
7149:
4941:
4867:
3997:
3886:
3852:
1366:
1–5 and 16–20 is expressed in most cell types. CD44 splice variants containing variable exons are designated CD44v. Some
6976:
5970:
5965:
5960:
5955:
4882:
1779:
3742:
Sun CX, Robb VA, Gutmann DH (November 2002). "Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation".
7016:
6566:
5935:
3955:
1616:
High levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia. Furthermore, because
319:
6866:
6069:
6034:
5171:
3562:"Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration"
2560:"Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration"
1697:
126:, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
3816:
Martin TA, Harrison G, Mansel RE, Jiang WG (May 2003). "The role of the CD44/ezrin complex in cancer metastasis".
6276:
6096:
5739:
5233:
4919:
1804:
1783:
1636:
296:
7154:
5378:
4914:
1621:
1335:
involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the
1013:
4019:
3713:
Yasuda M, Nakano K, Yasumoto K, Tanaka Y (2003). "CD44: functional relevance to inflammation and malignancy".
7159:
6086:
5875:
5347:
5342:
5287:
5021:
4470:
3519:"The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives"
218:
193:
994:
774:
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
6577:
5569:
5292:
135:
3779:
Ponta H, Sherman L, Herrlich PA (January 2003). "CD44: from adhesion molecules to signalling regulators".
1524:
demonstrate increased expression of splice variants of CD44, and increased adherence to peritoneal cells.
7113:
6592:
4887:
1673:
2702:
Sillanpää S, Anttila MA, Voutilainen K, Tammi RH, Tammi MI, Saarikoski SV, et al. (November 2003).
7103:
6514:
5599:
4024:
332:
231:
7066:
7026:
4465:
3913:
3466:"CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex"
1472:
325:
224:
122:
7006:
6981:
6546:
5649:
4544:
1562:
1435:
1413:
1237:
1233:
1229:
1225:
1221:
1206:
1202:
1198:
1188:
1184:
1180:
1176:
1142:
1138:
1134:
1130:
1126:
1111:
1107:
1103:
1093:
1089:
1085:
1081:
143:
3341:"Signaling through CD44 is mediated by tyrosine kinases. Association with p56lck in T lymphocytes"
1506:
In addition, variations in CD44 are reported as cell surface markers for some breast and prostate
5613:
3674:
1609:
oligonucleotides, and CD44-soluble proteins markedly reduces the malignant activities of various
1582:
3009:
Luxton HJ, Simpson BS, Mills IG, Brindle NR, Ahmed Z, Stavrinides V, et al. (August 2019).
1986:
Müller S, Sindikubwabo F, Cañeque T, Lafon A, Versini A, Lombard B, et al. (October 2020).
1247:
1172:
1152:
1077:
7164:
7041:
6585:
6061:
4956:
4951:
4946:
4936:
4243:
4171:
2703:
1554:
1459:
1455:
1343:
2411:
Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R, Konstantopoulos K (February 2006).
1853:
Spring FA, Dalchau R, Daniels GL, Mallinson G, Judson PA, Parsons SF, et al. (May 1988).
6253:
6026:
4300:
4218:
2866:
Quéré R, Andradottir S, Brun AC, Zubarev RA, Karlsson G, Olsson K, et al. (March 2011).
2043:
Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, et al. (May 2023).
1538:
1443:
207:
6225:
6211:
5537:
5250:
3906:
3152:
Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, et al. (May 2013).
2056:
1999:
1644:
1632:
1628:
1617:
1532:
1424:
3605:"The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing"
163:
8:
7046:
6971:
6858:
6835:
6799:
6771:
6090:
5564:
5383:
3892:
3656:
3639:
754:
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
2077:
2060:
2044:
2003:
6996:
4971:
4705:
3804:
3767:
3586:
3561:
3543:
3518:
3490:
3465:
3405:
3321:
3229:
3204:
3180:
3153:
3129:
3102:
3037:
3010:
2988:
2963:
Naor D, Nedvetzki S, Golan I, Melnik L, Faitelson Y (November 2002). "CD44 in cancer".
2940:
2892:
2867:
2808:
2783:
2759:
2734:
2638:
2611:
2584:
2559:
2535:
2508:
2442:
2369:"HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells"
2344:
2319:
2300:
2174:
2020:
1987:
1968:
1871:
1854:
167:
3829:
1920:
1895:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
646:
641:
636:
631:
626:
7071:
6900:
3833:
3796:
3759:
3730:
3701:
3691:
3661:
3626:
3621:
3604:
3591:
3577:
3548:
3495:
3446:
3397:
3362:
3313:
3309:
3278:
3234:
3185:
3134:
3083:
3042:
2980:
2932:
2897:
2848:
2813:
2764:
2750:
2715:
2684:
2643:
2589:
2575:
2540:
2486:
2434:
2390:
2349:
2292:
2253:
2218:
2166:
2126:
2082:
2025:
1960:
1956:
1925:
1876:
1606:
1507:
819:
negative regulation of DNA damage response, signal transduction by p53 class mediator
115:
47:
3808:
3771:
3409:
2992:
2944:
2446:
2178:
6986:
6803:
6756:
6391:
6057:
5744:
5477:
5398:
4961:
4154:
4080:
3825:
3788:
3751:
3722:
3683:
3651:
3616:
3581:
3573:
3538:
3530:
3485:
3477:
3436:
3389:
3352:
3339:
Taher TE, Smit L, Griffioen AW, Schilder-Tol EJ, Borst J, Pals ST (February 1996).
3325:
3305:
3268:
3224:
3216:
3175:
3165:
3124:
3114:
3073:
3032:
3022:
2972:
2924:
2887:
2879:
2840:
2803:
2795:
2754:
2746:
2674:
2633:
2623:
2579:
2571:
2530:
2520:
2476:
2424:
2380:
2339:
2331:
2304:
2284:
2245:
2208:
2158:
2121:
2116:
2104:
2072:
2064:
2015:
2007:
1972:
1952:
1915:
1907:
1866:
412:
343:
287:
242:
2213:
2196:
1400:
and internalizes metals bound to hyaluronic acid and can also interact with other
147:
6943:
6915:
6831:
5804:
4340:
4335:
4258:
3534:
3481:
2733:
Griffith JS, Liu YG, Tekmal RR, Binkley PA, Holden AE, Schenken RS (April 2010).
2413:"Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells"
1640:
1397:
1359:
387:
171:
3687:
3682:. Current Topics in Microbiology and Immunology. Vol. 184. pp. 47–63.
3101:
Chen X, Khajeh JA, Ju JH, Gupta YK, Stanley CB, Do C, et al. (March 2015).
1840:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1822:
National Center for
Biotechnology Information, U.S. National Library of Medicine
7093:
6612:
5589:
5011:
4522:
4325:
3205:"Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin"
2162:
2068:
1566:
1514:
1328:
488:
3273:
3256:
2976:
2011:
7138:
7098:
7086:
6766:
6373:
5559:
5016:
4107:
2249:
1590:
1521:
1383:
613:
584:
570:
6607:
3170:
3119:
3027:
2784:"CD44 variant isoforms in head and neck squamous cell carcinoma progression"
2704:"CD44 expression indicates favorable prognosis in epithelial ovarian cancer"
548:
426:
7011:
6923:
6790:
6620:
6616:
6344:
6340:
6336:
6332:
6125:
5915:
5223:
5213:
4744:
4710:
3837:
3800:
3763:
3734:
3673:
Günthert U (1993). "CD44: A Multitude of
Isoforms with Diverse Functions".
3665:
3630:
3595:
3552:
3499:
3450:
3441:
3424:
3401:
3357:
3340:
3189:
3138:
3087:
3078:
3061:
3046:
2984:
2901:
2852:
2817:
2768:
2719:
2688:
2647:
2628:
2593:
2544:
2525:
2490:
2481:
2464:
2438:
2394:
2385:
2368:
2353:
2335:
2320:"CD44 is a major E-selectin ligand on human hematopoietic progenitor cells"
2296:
2257:
2222:
2197:"CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity"
2170:
2105:"Detection of an L-selectin ligand on a hematopoietic progenitor cell line"
2086:
2029:
1929:
1570:
1439:
1358:
CD44 is expressed in a large number of mammalian cell types. The standard
1347:
1332:
577:
405:
184:
3705:
3394:
10.1002/(SICI)1097-4652(200007)184:1<118::AID-JCP13>3.0.CO;2-Y
3366:
3317:
3282:
3238:
3220:
2936:
2679:
2662:
2429:
2412:
2130:
1964:
1880:
1311:
1306:
7123:
7118:
7108:
7081:
7051:
7036:
6905:
6761:
6751:
6628:
6417:
6350:
6310:
6300:
5925:
5574:
5352:
5327:
5026:
4648:
4574:
4048:
2883:
2830:
1737:
1713:
1598:
1558:
1542:
1405:
1058:
1039:
2844:
1911:
30:
6951:
6523:
6494:
6489:
6484:
6407:
6328:
5855:
5579:
5260:
5001:
4877:
4510:
4505:
4500:
4355:
4139:
3726:
3464:
Shi X, Leng L, Wang T, Wang W, Du X, Li J, et al. (October 2006).
2928:
2799:
2507:
Thomas SN, Zhu F, Schnaar RL, Alves CS, Konstantopoulos K (June 2008).
2318:
Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R (June 2001).
1748:
1725:
1707:
1578:
1511:
1390:
1379:
1367:
1350:-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1.
304:
201:
151:
3755:
92:
88:
84:
80:
76:
7061:
7056:
7031:
7021:
6933:
6320:
6120:
5694:
5689:
5684:
5674:
5669:
5664:
5659:
2194:
1742:
1594:
1574:
1458:
receptor", directing migration of human hematopoietic stem cells and
913:
371:
358:
270:
257:
159:
3792:
2463:
Napier SL, Healy ZR, Schnaar RL, Konstantopoulos K (February 2007).
1988:"CD44 regulates epigenetic plasticity by mediating iron endocytosis"
1378:
CD44 participates in a wide variety of cellular functions including
6880:
6875:
6870:
6848:
6843:
6821:
6816:
6776:
6529:
6476:
6285:
6189:
6078:
6000:
5900:
5714:
5699:
4902:
4897:
4805:
4495:
3949:: SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44
3640:"Cancer cells in transit: the vascular interactions of tumor cells"
2288:
2195:
Hanley WD, Burdick MM, Konstantopoulos K, Sackstein R (July 2005).
1610:
1602:
1586:
1409:
1370:
also express a larger isoform (CD44E), which includes exons v8–10.
1295:
2782:
Wang SJ, Wong G, de Heer AM, Xia W, Bourguignon LY (August 2009).
2610:
Alves CS, Yakovlev S, Medved L, Konstantopoulos K (January 2009).
2609:
6928:
6811:
6608:
5950:
5945:
5940:
5840:
5654:
5644:
5471:
5450:
5445:
5413:
5218:
5138:
5133:
5128:
5123:
5118:
5036:
4729:
4569:
4564:
4559:
4554:
4549:
4020:
3295:
2462:
1942:
1681:
1649:
1528:
1428:
1025:
980:
898:
894:
2701:
2045:"A druggable copper-signalling pathway that drives inflammation"
139:
7001:
6720:
6680:
6386:
6257:
6147:
6110:
6100:
5890:
5850:
5835:
5819:
5814:
5794:
5789:
5724:
5532:
5502:
5466:
5457:
5270:
5238:
5102:
5097:
5067:
5046:
5006:
4966:
4832:
4810:
4769:
4693:
4688:
4683:
4678:
4673:
4668:
4537:
4532:
4527:
4475:
4460:
4330:
4320:
4283:
4278:
4196:
4191:
3060:
Bourguignon LY, Singleton PA, Zhu H, Diedrich F (August 2003).
3059:
1703:
1653:
1488:
1484:
1401:
1279:
935:
6056:
3898:
3338:
1985:
1601:. Experiments in animals have shown that targeting of CD44 by
593:
6895:
6890:
6735:
6730:
6725:
6715:
6710:
6705:
6685:
6670:
6665:
6650:
6637:
6561:
6538:
6534:
6462:
6452:
6447:
6442:
6437:
6432:
6381:
6261:
6243:
6239:
6229:
6215:
6201:
6177:
6172:
6167:
6162:
6157:
6152:
6135:
6130:
6104:
6015:
5990:
5910:
5905:
5895:
5885:
5870:
5865:
5860:
5845:
5799:
5784:
5749:
5734:
5729:
5719:
5639:
5634:
5629:
5608:
5604:
5594:
5507:
5408:
5403:
5362:
5312:
5307:
5302:
5297:
5282:
5275:
5255:
5243:
5186:
5181:
5176:
5166:
5161:
5154:
5092:
5082:
5077:
5072:
5062:
5041:
5031:
4996:
4991:
4986:
4981:
4976:
4931:
4926:
4892:
4857:
4852:
4847:
4837:
4825:
4820:
4800:
4795:
4790:
4785:
4739:
4631:
4626:
4445:
4429:
4422:
4417:
4412:
4407:
4402:
4397:
4372:
4350:
4345:
4238:
4164:
4159:
4149:
3856:
1852:
1687:
1387:
3979:: hyaluronan-binding domain of CD44 in its ligand-bound form
1342:
on chromosome 11. CD44 has been referred to as HCAM (homing
7076:
6991:
6700:
6695:
6690:
6675:
6660:
6655:
6645:
6551:
6457:
6427:
6422:
6412:
6362:
6358:
6354:
6305:
6247:
6233:
6219:
6205:
6140:
6115:
6010:
6005:
5995:
5985:
5980:
5975:
5930:
5920:
5880:
5809:
5779:
5774:
5769:
5764:
5759:
5754:
5709:
5679:
5584:
5552:
5547:
5527:
5517:
5512:
5497:
5492:
5393:
5388:
5357:
5337:
5332:
5322:
5317:
5196:
5149:
5109:
4764:
4759:
4754:
4749:
4734:
4725:
4720:
4715:
4700:
4658:
4653:
4643:
4638:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4517:
4490:
4485:
4480:
4455:
4450:
4387:
4382:
4377:
4362:
4315:
4310:
4305:
4295:
4290:
4273:
4268:
4263:
4253:
4248:
4233:
4228:
4223:
4213:
4208:
4203:
4186:
4181:
4176:
4127:
4095:
4090:
4085:
4068:
4063:
4058:
4053:
3151:
2914:
2865:
2317:
1754:
1691:
1657:
1613:, stressing the therapeutic potential of anti-CD44 agents.
1480:
1420:
1363:
1339:
3712:
2410:
2273:
2042:
5522:
4134:
4122:
4117:
4112:
4102:
4075:
4043:
3864:
3815:
3008:
1731:
1719:
2962:
2732:
2366:
1639:
is associated with a favorable outcome. This is true of
829:
positive regulation of peptidyl-tyrosine phosphorylation
395:
3254:
2663:"Beyond tumorigenesis: cancer stem cells in metastasis"
2148:
673:
macrophage migration inhibitory factor receptor complex
3422:
3379:
804:
positive regulation of peptidyl-serine phosphorylation
799:
cellular response to fibroblast growth factor stimulus
3637:
3423:
Bourguignon LY, Zhu H, Shao L, Chen YW (March 2001).
2506:
2367:
Burdick MM, Chu JT, Godar S, Sackstein R (May 2006).
764:
positive regulation of heterotypic cell-cell adhesion
560:
3778:
1893:
2660:
1353:
2781:
2661:Li F, Tiede B, Massagué J, Kang Y (January 2007).
2235:
1796:
1794:
1792:
1775:
1773:
1771:
3100:
1652:and became included in the presence of increased
342:
241:
7136:
3676:Adhesion in Leukocyte Homing and Differentiation
3202:
2965:Critical Reviews in Clinical Laboratory Sciences
3463:
3255:Ilangumaran S, Briol A, Hoessli DC (May 1998).
2605:
2603:
2502:
2500:
2458:
2456:
2406:
2404:
2269:
2267:
2190:
2188:
2151:American Journal of Physiology. Cell Physiology
2144:
2142:
2140:
1789:
1768:
3859:Blood Group Antigen Gene Mutation Database at
3741:
3250:
3248:
2102:
2098:
2096:
1894:Goodison S, Urquidi V, Tarin D (August 1999).
1801:GRCm38: Ensembl release 89: ENSMUSG00000005087
1553:CD44 is a multistructural and multifunctional
6593:
6042:
4005:
3914:
3416:
3053:
2726:
2695:
2654:
2600:
2551:
2497:
2453:
2401:
2360:
2311:
2264:
2229:
2185:
2137:
824:positive regulation of ERK1 and ERK2 cascade
3332:
3289:
3245:
3196:
2093:
1887:
1780:GRCh38: Ensembl release 89: ENSG00000026508
1427:that results in many functionally distinct
839:positive regulation of monocyte aggregation
779:interferon-gamma-mediated signaling pathway
6600:
6586:
6049:
6035:
4012:
3998:
3921:
3907:
1846:
1581:, and growth factors to the corresponding
4029:list of human clusters of differentiation
3964:: HYALURONAN BINDING DOMAIN OF HUMAN CD44
3655:
3620:
3602:
3585:
3559:
3542:
3516:
3489:
3440:
3356:
3272:
3228:
3179:
3169:
3128:
3118:
3077:
3036:
3026:
2891:
2824:
2807:
2758:
2678:
2637:
2627:
2583:
2557:
2534:
2524:
2480:
2428:
2384:
2343:
2212:
2120:
2076:
2019:
1919:
1870:
859:regulation of lamellipodium morphogenesis
647:transmembrane signaling receptor activity
3672:
3609:The Journal of Investigative Dermatology
3203:Jalkanen S, Jalkanen M (February 1992).
2775:
1531:are also relevant to the progression of
1466:
794:negative regulation of apoptotic process
6906:Structural maintenance of chromosomes 3
3818:Critical Reviews in Oncology/Hematology
3644:Annual Review of Biomedical Engineering
3457:
2103:Oxley SM, Sackstein R (November 1994).
1382:activation, recirculation and homing,
7137:
3781:Nature Reviews. Molecular Cell Biology
884:positive regulation of kinase activity
6581:
6030:
3993:
3902:
3638:Konstantopoulos K, Thomas SN (2009).
3373:
3004:
3002:
2958:
2956:
2954:
1533:head and neck squamous cell carcinoma
1471:The protein is a determinant for the
1446:(also linked to tumour development).
693:integral component of plasma membrane
347:
308:
303:
246:
205:
200:
3657:10.1146/annurev-bioeng-061008-124949
531:endothelial cell of lymphatic vessel
3429:The Journal of Biological Chemistry
3345:The Journal of Biological Chemistry
3158:The Journal of Biological Chemistry
3107:The Journal of Biological Chemistry
3066:The Journal of Biological Chemistry
2616:The Journal of Biological Chemistry
2513:The Journal of Biological Chemistry
2469:The Journal of Biological Chemistry
2373:The Journal of Biological Chemistry
13:
3509:
2999:
2951:
14:
7176:
7017:Cholesterylester transfer protein
6867:Chondroitin sulfate proteoglycans
3846:
1548:
1438:is at least in part activated by
854:wound healing, spreading of cells
789:extracellular matrix organization
3969:
3954:
3939:
3622:10.1111/j.0022-202X.2004.09301.x
3578:10.1111/j.1600-065X.2009.00792.x
2751:10.1016/j.fertnstert.2008.12.012
2576:10.1111/j.1600-065X.2009.00792.x
1698:Epidermal Growth Factor Receptor
1520:Endometrial cells in women with
1354:Tissue distribution and isoforms
784:extracellular matrix disassembly
583:
576:
569:
331:
324:
318:
295:
230:
223:
217:
192:
29:
3928:
3145:
3094:
2908:
2859:
1667:
1622:posttranslational modifications
1362:, designated CD44s, comprising
3382:Journal of Cellular Physiology
2122:10.1182/blood.V84.10.3299.3299
2036:
1979:
1936:
1896:"CD44 cell adhesion molecules"
1828:
1810:
1593:, as well as in signaling for
1541:against CD44 variants include
663:integral component of membrane
594:More reference expression data
549:More reference expression data
1:
3830:10.1016/S1040-8428(02)00172-5
3523:Current Opinion in Hematology
2214:10.1158/0008-5472.CAN-04-4557
1762:
316:
215:
7145:Genes on human chromosome 11
3715:Histology and Histopathology
3535:10.1097/MOH.0b013e3283476140
3482:10.1016/j.immuni.2006.08.020
3310:10.1016/0092-8674(90)90694-A
2833:Histology and Histopathology
1957:10.1016/0092-8674(90)90694-a
769:hyaluronan catabolic process
7:
7150:Clusters of differentiation
7114:Tumor necrosis factor alpha
4025:clusters of differentiation
3688:10.1007/978-3-642-78253-4_4
3209:The Journal of Cell Biology
2324:The Journal of Cell Biology
1373:
738:basolateral plasma membrane
441:stromal cell of endometrium
10:
7181:
7104:Thyroxine-binding proteins
6515:Lymphocyte homing receptor
3891:gene details page in the
2163:10.1152/ajpcell.00463.2007
2069:10.1038/s41586-023-06017-4
713:secretory granule membrane
642:cytokine receptor activity
7067:Serum amyloid P component
7027:Colony-stimulating factor
6964:
6942:
6914:
6857:
6830:
6798:
6789:
6744:
6636:
6627:
6507:
6475:
6400:
6372:
6319:
6293:
6284:
6275:
6188:
6077:
6068:
5828:
5622:
5371:
5055:
4778:
4438:
4036:
3934:
3853:Indian blood group system
3560:Sackstein R (July 2009).
3517:Sackstein R (July 2011).
3274:10.1182/blood.V91.10.3901
2977:10.1080/10408360290795574
2917:Journal of Neuro-Oncology
2558:Sackstein R (July 2009).
2012:10.1038/s41557-020-0513-5
1836:"Mouse PubMed Reference:"
1818:"Human PubMed Reference:"
1483:, is used to track early
1473:Indian blood group system
1414:matrix metalloproteinases
1310:
1305:
1301:
1294:
1278:
1272:Chr 2: 102.64 – 102.73 Mb
1259:
1244:
1220:
1195:
1171:
1164:
1149:
1125:
1100:
1076:
1069:
1056:
1052:
1037:
1033:
1024:
1011:
1007:
992:
988:
979:
966:
962:
947:
943:
934:
919:
912:
908:
892:
612:
608:
591:
568:
559:
546:
495:
486:
433:
424:
394:
386:
382:
365:
352:
315:
294:
285:
281:
264:
251:
214:
191:
182:
178:
133:
130:
120:
113:
108:
73:
68:
51:
46:
41:
37:
28:
23:
16:Cell-surface glycoprotein
7007:B-cell activating factor
6982:Alpha 1-antichymotrypsin
6547:Carcinoembryonic antigen
6401:Unconventional/ungrouped
3603:Sackstein R (May 2004).
2708:Clinical Cancer Research
2250:10.1182/blood.V96.8.2765
1449:
1265:Chr 11: 35.14 – 35.23 Mb
849:neutrophil degranulation
6062:cell adhesion molecules
3744:Journal of Cell Science
3171:10.1074/jbc.M113.451336
3120:10.1074/jbc.M114.589523
3028:10.3390/cancers11091233
2739:Fertility and Sterility
1700:(Hyaluronan-dependent),
1672:CD44 has been shown to
1633:non-Hodgkin's lymphomas
1396:CD44 is a receptor for
637:hyaluronic acid binding
7042:Membrane glycoproteins
3442:10.1074/jbc.M006498200
3358:10.1074/jbc.271.5.2863
3079:10.1074/jbc.M301885200
2629:10.1074/jbc.M805144200
2526:10.1074/jbc.M800543200
2482:10.1074/jbc.M607219200
2386:10.1074/jbc.M513617200
2336:10.1083/jcb.153.6.1277
1460:mesenchymal stem cells
1344:cell adhesion molecule
723:lamellipodium membrane
718:apical plasma membrane
7155:Blood antigen systems
6254:Glycoprotein IIb/IIIa
3566:Immunological Reviews
3221:10.1083/jcb.116.3.817
2680:10.1038/sj.cr.7310118
2564:Immunological Reviews
2430:10.1096/fj.05-4574fje
1555:cell surface molecule
1539:Monoclonal antibodies
1467:Clinical significance
1419:Transcripts for this
1346:), Pgp-1 (phagocytic
869:inflammatory response
809:cartilage development
703:extracellular exosome
208:Chromosome 11 (human)
7160:Transfusion medicine
6226:Macrophage-1 antigen
6212:Integrin alphaXbeta2
3885:genome location and
3750:(Pt 21): 3991–4000.
2884:10.1038/leu.2010.281
1618:alternative splicing
1563:cell differentiation
1425:alternative splicing
834:cell-matrix adhesion
759:monocyte aggregation
349:2 E2|2 54.13 cM
310:Chromosome 2 (mouse)
69:List of PDB id codes
42:Available structures
7047:Myelin protein zero
6972:Activin and inhibin
6772:Phytohaemagglutinin
6091:Myelin protein zero
6070:Calcium-independent
3893:UCSC Genome Browser
3164:(21): 14824–14838.
3072:(32): 29420–29434.
2845:10.14670/HH-17.1269
2519:(23): 15647–15655.
2379:(20): 13899–13905.
2061:2023Natur.617..386S
2004:2020NatCh..12..929M
1912:10.1136/mp.52.4.189
1900:Molecular Pathology
1487:development in the
844:leukocyte migration
515:submandibular gland
473:islet of Langerhans
449:gingival epithelium
6997:Asialoglycoprotein
3727:10.14670/HH-17.945
2929:10.1007/bf01052619
2800:10.1002/lary.20506
1645:transcript variant
1573:, presentation of
1559:cell proliferation
1014:ENSMUSG00000005087
864:cell-cell adhesion
747:Biological process
656:Cellular component
620:Molecular function
523:tibiofemoral joint
519:epithelium of lens
7132:
7131:
7072:Sialoglycoprotein
6960:
6959:
6901:Platelet factor 4
6785:
6784:
6575:
6574:
6503:
6502:
6471:
6470:
6277:Calcium-dependent
6271:
6270:
6058:Membrane proteins
6024:
6023:
3987:
3986:
3756:10.1242/jcs.00094
3697:978-3-642-78255-8
3435:(10): 7327–7336.
3267:(10): 3901–3908.
3113:(10): 6639–6652.
2714:(14): 5318–5324.
2207:(13): 5812–5817.
2115:(10): 3299–3306.
2055:(7960): 386–394.
1627:In many cancers (
1585:, and docking of
1508:cancer stem cells
1502:chemical tagging.
1479:CD44, along with
1321:
1320:
1317:
1316:
1290:
1289:
1255:
1254:
1214:
1213:
1160:
1159:
1119:
1118:
1065:
1064:
1046:
1045:
1020:
1019:
1001:
1000:
975:
974:
956:
955:
904:
903:
879:T cell activation
604:
603:
600:
599:
555:
554:
542:
541:
480:
479:
378:
377:
277:
276:
104:
103:
100:
99:
52:Ortholog search:
7172:
6987:Apolipoprotein H
6796:
6795:
6757:Intrinsic factor
6634:
6633:
6602:
6595:
6588:
6579:
6578:
6291:
6290:
6282:
6281:
6075:
6074:
6051:
6044:
6037:
6028:
6027:
4014:
4007:
4000:
3991:
3990:
3973:
3958:
3943:
3923:
3916:
3909:
3900:
3899:
3841:
3812:
3775:
3738:
3709:
3681:
3669:
3659:
3634:
3624:
3615:(5): 1061–1069.
3599:
3589:
3556:
3546:
3504:
3503:
3493:
3461:
3455:
3454:
3444:
3420:
3414:
3413:
3377:
3371:
3370:
3360:
3351:(5): 2863–2867.
3336:
3330:
3329:
3304:(7): 1303–1313.
3293:
3287:
3286:
3276:
3252:
3243:
3242:
3232:
3200:
3194:
3193:
3183:
3173:
3149:
3143:
3142:
3132:
3122:
3098:
3092:
3091:
3081:
3057:
3051:
3050:
3040:
3030:
3006:
2997:
2996:
2960:
2949:
2948:
2912:
2906:
2905:
2895:
2863:
2857:
2856:
2839:(4): 1269–1281.
2828:
2822:
2821:
2811:
2794:(8): 1518–1530.
2788:The Laryngoscope
2779:
2773:
2772:
2762:
2745:(6): 1745–1749.
2730:
2724:
2723:
2699:
2693:
2692:
2682:
2658:
2652:
2651:
2641:
2631:
2622:(2): 1177–1189.
2607:
2598:
2597:
2587:
2555:
2549:
2548:
2538:
2528:
2504:
2495:
2494:
2484:
2475:(6): 3433–3441.
2460:
2451:
2450:
2432:
2408:
2399:
2398:
2388:
2364:
2358:
2357:
2347:
2330:(6): 1277–1286.
2315:
2309:
2308:
2271:
2262:
2261:
2244:(8): 2765–2774.
2233:
2227:
2226:
2216:
2192:
2183:
2182:
2157:(4): C907–C916.
2146:
2135:
2134:
2124:
2100:
2091:
2090:
2080:
2040:
2034:
2033:
2023:
1992:Nature Chemistry
1983:
1977:
1976:
1951:(7): 1303–1313.
1940:
1934:
1933:
1923:
1891:
1885:
1884:
1874:
1850:
1844:
1843:
1832:
1826:
1825:
1814:
1808:
1798:
1787:
1777:
1706:and immobilized
1423:undergo complex
1368:epithelial cells
1303:
1302:
1274:
1267:
1250:
1218:
1217:
1209:
1169:
1168:
1165:RefSeq (protein)
1155:
1123:
1122:
1114:
1074:
1073:
1050:
1049:
1031:
1030:
1005:
1004:
986:
985:
960:
959:
941:
940:
910:
909:
627:collagen binding
610:
609:
596:
587:
580:
573:
566:
565:
551:
491:
489:Top expressed in
484:
483:
429:
427:Top expressed in
422:
421:
401:
400:
384:
383:
374:
361:
350:
335:
328:
322:
311:
299:
283:
282:
273:
260:
249:
234:
227:
221:
210:
196:
180:
179:
174:
172:CD44 - orthologs
125:
118:
95:
66:
65:
60:
39:
38:
33:
21:
20:
7180:
7179:
7175:
7174:
7173:
7171:
7170:
7169:
7135:
7134:
7133:
7128:
6956:
6938:
6910:
6853:
6826:
6781:
6740:
6623:
6606:
6576:
6571:
6499:
6467:
6396:
6368:
6315:
6267:
6184:
6064:
6055:
6025:
6020:
5824:
5618:
5367:
5051:
4774:
4434:
4032:
4018:
3988:
3983:
3980:
3974:
3965:
3959:
3950:
3944:
3930:
3927:
3849:
3844:
3793:10.1038/nrm1004
3698:
3679:
3512:
3510:Further reading
3507:
3462:
3458:
3421:
3417:
3378:
3374:
3337:
3333:
3294:
3290:
3253:
3246:
3201:
3197:
3150:
3146:
3099:
3095:
3058:
3054:
3007:
3000:
2961:
2952:
2913:
2909:
2864:
2860:
2829:
2825:
2780:
2776:
2731:
2727:
2700:
2696:
2659:
2655:
2608:
2601:
2556:
2552:
2505:
2498:
2461:
2454:
2409:
2402:
2365:
2361:
2316:
2312:
2277:Nature Medicine
2272:
2265:
2234:
2230:
2201:Cancer Research
2193:
2186:
2147:
2138:
2101:
2094:
2041:
2037:
1998:(10): 929–938.
1984:
1980:
1941:
1937:
1892:
1888:
1851:
1847:
1834:
1833:
1829:
1816:
1815:
1811:
1799:
1790:
1778:
1769:
1765:
1760:
1670:
1664:human cancers.
1641:prostate cancer
1551:
1469:
1452:
1398:hyaluronic acid
1376:
1356:
1312:View/Edit Mouse
1307:View/Edit Human
1270:
1263:
1260:Location (UCSC)
1246:
1240:
1236:
1232:
1228:
1224:
1205:
1201:
1197:
1191:
1187:
1183:
1179:
1175:
1151:
1145:
1141:
1137:
1133:
1129:
1110:
1106:
1102:
1096:
1092:
1088:
1084:
1080:
995:ENSG00000026508
888:
742:
728:cell projection
688:plasma membrane
668:Golgi apparatus
651:
632:protein binding
592:
582:
581:
575:
574:
547:
538:
533:
529:
525:
521:
517:
513:
509:
505:
501:
487:
476:
471:
467:
465:Achilles tendon
463:
461:skin of abdomen
459:
455:
451:
447:
443:
439:
425:
369:
356:
348:
338:
337:
336:
329:
309:
286:Gene location (
268:
255:
247:
237:
236:
235:
228:
206:
183:Gene location (
134:
121:
114:
75:
53:
17:
12:
11:
5:
7178:
7168:
7167:
7162:
7157:
7152:
7147:
7130:
7129:
7127:
7126:
7121:
7116:
7111:
7106:
7101:
7096:
7094:Thrombopoietin
7091:
7090:
7089:
7084:
7079:
7069:
7064:
7059:
7054:
7049:
7044:
7039:
7034:
7029:
7024:
7019:
7014:
7009:
7004:
6999:
6994:
6989:
6984:
6979:
6974:
6968:
6966:
6962:
6961:
6958:
6957:
6955:
6954:
6948:
6946:
6940:
6939:
6937:
6936:
6931:
6926:
6920:
6918:
6912:
6911:
6909:
6908:
6903:
6898:
6893:
6888:
6883:
6878:
6873:
6863:
6861:
6855:
6854:
6852:
6851:
6846:
6840:
6838:
6828:
6827:
6825:
6824:
6819:
6814:
6808:
6806:
6793:
6787:
6786:
6783:
6782:
6780:
6779:
6774:
6769:
6764:
6759:
6754:
6748:
6746:
6742:
6741:
6739:
6738:
6733:
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6693:
6688:
6683:
6678:
6673:
6668:
6663:
6658:
6653:
6648:
6642:
6640:
6631:
6625:
6624:
6613:glycoconjugate
6605:
6604:
6597:
6590:
6582:
6573:
6572:
6570:
6569:
6564:
6559:
6554:
6549:
6543:
6542:
6526:
6521:
6511:
6509:
6505:
6504:
6501:
6500:
6498:
6497:
6492:
6487:
6481:
6479:
6473:
6472:
6469:
6468:
6466:
6465:
6460:
6455:
6450:
6445:
6440:
6435:
6430:
6425:
6420:
6415:
6410:
6404:
6402:
6398:
6397:
6395:
6394:
6389:
6384:
6378:
6376:
6370:
6369:
6367:
6366:
6348:
6325:
6323:
6317:
6316:
6314:
6313:
6308:
6303:
6297:
6295:
6288:
6279:
6273:
6272:
6269:
6268:
6266:
6265:
6251:
6237:
6223:
6209:
6194:
6192:
6186:
6185:
6183:
6182:
6181:
6180:
6175:
6170:
6165:
6160:
6155:
6145:
6144:
6143:
6138:
6133:
6128:
6118:
6113:
6108:
6094:
6083:
6081:
6072:
6066:
6065:
6054:
6053:
6046:
6039:
6031:
6022:
6021:
6019:
6018:
6013:
6008:
6003:
5998:
5993:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5918:
5913:
5908:
5903:
5898:
5893:
5888:
5883:
5878:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5832:
5830:
5826:
5825:
5823:
5822:
5817:
5812:
5807:
5802:
5797:
5792:
5787:
5782:
5777:
5772:
5767:
5762:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5707:
5702:
5697:
5692:
5687:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5647:
5642:
5637:
5632:
5626:
5624:
5620:
5619:
5617:
5616:
5611:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5556:
5555:
5550:
5540:
5535:
5530:
5525:
5520:
5515:
5510:
5505:
5500:
5495:
5490:
5485:
5480:
5475:
5469:
5460:
5455:
5454:
5453:
5448:
5438:
5433:
5432:
5431:
5426:
5416:
5411:
5406:
5401:
5396:
5391:
5386:
5381:
5375:
5373:
5369:
5368:
5366:
5365:
5360:
5355:
5350:
5345:
5340:
5335:
5330:
5325:
5320:
5315:
5310:
5305:
5300:
5295:
5290:
5285:
5280:
5279:
5278:
5273:
5263:
5258:
5253:
5248:
5247:
5246:
5241:
5236:
5226:
5221:
5216:
5211:
5206:
5205:
5204:
5199:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5158:
5157:
5152:
5142:
5136:
5131:
5126:
5121:
5112:
5107:
5106:
5105:
5100:
5095:
5085:
5080:
5075:
5070:
5065:
5059:
5057:
5053:
5052:
5050:
5049:
5044:
5039:
5034:
5029:
5024:
5019:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4929:
4924:
4923:
4922:
4917:
4907:
4906:
4905:
4900:
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4829:
4828:
4823:
4813:
4808:
4803:
4798:
4793:
4788:
4782:
4780:
4776:
4775:
4773:
4772:
4767:
4762:
4757:
4752:
4747:
4742:
4737:
4732:
4723:
4718:
4713:
4708:
4703:
4698:
4697:
4696:
4691:
4686:
4681:
4676:
4671:
4661:
4656:
4651:
4646:
4641:
4636:
4635:
4634:
4629:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4579:
4578:
4577:
4572:
4567:
4562:
4557:
4552:
4542:
4541:
4540:
4535:
4530:
4520:
4515:
4514:
4513:
4508:
4503:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4442:
4440:
4436:
4435:
4433:
4432:
4427:
4426:
4425:
4420:
4415:
4410:
4405:
4400:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4359:
4358:
4353:
4348:
4343:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4287:
4286:
4281:
4271:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4200:
4199:
4194:
4184:
4179:
4174:
4169:
4168:
4167:
4162:
4157:
4152:
4142:
4137:
4132:
4131:
4130:
4120:
4115:
4110:
4105:
4100:
4099:
4098:
4093:
4088:
4078:
4073:
4072:
4071:
4066:
4061:
4056:
4051:
4040:
4038:
4034:
4033:
4017:
4016:
4009:
4002:
3994:
3985:
3984:
3982:
3981:
3975:
3968:
3966:
3960:
3953:
3951:
3945:
3938:
3935:
3932:
3931:
3926:
3925:
3918:
3911:
3903:
3897:
3896:
3877:
3867:
3848:
3847:External links
3845:
3843:
3842:
3824:(2): 165–186.
3813:
3776:
3739:
3721:(3): 945–950.
3710:
3696:
3670:
3635:
3600:
3557:
3529:(4): 239–248.
3513:
3511:
3508:
3506:
3505:
3476:(4): 595–606.
3456:
3415:
3388:(1): 118–130.
3372:
3331:
3288:
3244:
3215:(3): 817–825.
3195:
3144:
3093:
3052:
2998:
2971:(6): 527–579.
2950:
2923:(3): 165–170.
2907:
2878:(3): 515–526.
2858:
2823:
2774:
2725:
2694:
2653:
2599:
2550:
2496:
2452:
2423:(2): 337–339.
2400:
2359:
2310:
2289:10.1038/nm1703
2283:(2): 181–187.
2263:
2228:
2184:
2136:
2092:
2035:
1978:
1935:
1906:(4): 189–196.
1886:
1845:
1827:
1809:
1788:
1766:
1764:
1761:
1759:
1758:
1752:
1746:
1740:
1735:
1729:
1723:
1717:
1711:
1701:
1695:
1685:
1678:
1669:
1666:
1567:cell migration
1550:
1549:CD44 in cancer
1547:
1515:ovarian cancer
1504:
1503:
1492:
1468:
1465:
1451:
1448:
1444:Wnt signalling
1375:
1372:
1355:
1352:
1319:
1318:
1315:
1314:
1309:
1299:
1298:
1292:
1291:
1288:
1287:
1285:
1283:
1276:
1275:
1268:
1261:
1257:
1256:
1253:
1252:
1242:
1241:
1215:
1212:
1211:
1193:
1192:
1166:
1162:
1161:
1158:
1157:
1147:
1146:
1120:
1117:
1116:
1098:
1097:
1071:
1067:
1066:
1063:
1062:
1054:
1053:
1047:
1044:
1043:
1035:
1034:
1028:
1022:
1021:
1018:
1017:
1009:
1008:
1002:
999:
998:
990:
989:
983:
977:
976:
973:
972:
964:
963:
957:
954:
953:
945:
944:
938:
932:
931:
926:
921:
917:
916:
906:
905:
902:
901:
890:
889:
887:
886:
881:
876:
874:cell migration
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
750:
748:
744:
743:
741:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
683:focal adhesion
680:
675:
670:
665:
659:
657:
653:
652:
650:
649:
644:
639:
634:
629:
623:
621:
617:
616:
606:
605:
602:
601:
598:
597:
589:
588:
563:
557:
556:
553:
552:
544:
543:
540:
539:
537:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
493:
492:
481:
478:
477:
475:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
431:
430:
418:
417:
409:
398:
392:
391:
388:RNA expression
380:
379:
376:
375:
367:
363:
362:
354:
351:
346:
340:
339:
330:
323:
317:
313:
312:
307:
301:
300:
292:
291:
279:
278:
275:
274:
266:
262:
261:
253:
250:
245:
239:
238:
229:
222:
216:
212:
211:
204:
198:
197:
189:
188:
176:
175:
132:
128:
127:
119:
111:
110:
106:
105:
102:
101:
98:
97:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
7177:
7166:
7165:Glycoproteins
7163:
7161:
7158:
7156:
7153:
7151:
7148:
7146:
7143:
7142:
7140:
7125:
7122:
7120:
7117:
7115:
7112:
7110:
7107:
7105:
7102:
7100:
7099:Thyroglobulin
7097:
7095:
7092:
7088:
7087:Glycophorin C
7085:
7083:
7080:
7078:
7075:
7074:
7073:
7070:
7068:
7065:
7063:
7060:
7058:
7055:
7053:
7050:
7048:
7045:
7043:
7040:
7038:
7035:
7033:
7030:
7028:
7025:
7023:
7020:
7018:
7015:
7013:
7010:
7008:
7005:
7003:
7000:
6998:
6995:
6993:
6990:
6988:
6985:
6983:
6980:
6978:
6975:
6973:
6970:
6969:
6967:
6963:
6953:
6950:
6949:
6947:
6945:
6941:
6935:
6932:
6930:
6927:
6925:
6922:
6921:
6919:
6917:
6913:
6907:
6904:
6902:
6899:
6897:
6894:
6892:
6889:
6887:
6884:
6882:
6879:
6877:
6874:
6872:
6868:
6865:
6864:
6862:
6860:
6856:
6850:
6847:
6845:
6842:
6841:
6839:
6837:
6833:
6829:
6823:
6820:
6818:
6815:
6813:
6810:
6809:
6807:
6805:
6801:
6797:
6794:
6792:
6791:Proteoglycans
6788:
6778:
6775:
6773:
6770:
6768:
6767:Peptidoglycan
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6749:
6747:
6743:
6737:
6734:
6732:
6729:
6727:
6724:
6722:
6719:
6717:
6714:
6712:
6709:
6707:
6704:
6702:
6699:
6697:
6694:
6692:
6689:
6687:
6684:
6682:
6679:
6677:
6674:
6672:
6669:
6667:
6664:
6662:
6659:
6657:
6654:
6652:
6649:
6647:
6644:
6643:
6641:
6639:
6635:
6632:
6630:
6626:
6622:
6621:glycopeptides
6618:
6617:glycoproteins
6614:
6610:
6603:
6598:
6596:
6591:
6589:
6584:
6583:
6580:
6568:
6565:
6563:
6560:
6558:
6555:
6553:
6550:
6548:
6545:
6544:
6540:
6536:
6532:
6531:
6527:
6525:
6522:
6520:
6516:
6513:
6512:
6510:
6506:
6496:
6493:
6491:
6488:
6486:
6483:
6482:
6480:
6478:
6474:
6464:
6461:
6459:
6456:
6454:
6451:
6449:
6446:
6444:
6441:
6439:
6436:
6434:
6431:
6429:
6426:
6424:
6421:
6419:
6416:
6414:
6411:
6409:
6406:
6405:
6403:
6399:
6393:
6390:
6388:
6385:
6383:
6380:
6379:
6377:
6375:
6374:Protocadherin
6371:
6364:
6360:
6356:
6352:
6349:
6346:
6342:
6338:
6334:
6330:
6327:
6326:
6324:
6322:
6318:
6312:
6309:
6307:
6304:
6302:
6299:
6298:
6296:
6292:
6289:
6287:
6283:
6280:
6278:
6274:
6263:
6259:
6255:
6252:
6249:
6245:
6241:
6238:
6235:
6231:
6227:
6224:
6221:
6217:
6213:
6210:
6207:
6203:
6199:
6196:
6195:
6193:
6191:
6187:
6179:
6176:
6174:
6171:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6150:
6149:
6146:
6142:
6139:
6137:
6134:
6132:
6129:
6127:
6124:
6123:
6122:
6119:
6117:
6114:
6112:
6109:
6106:
6102:
6098:
6095:
6092:
6088:
6085:
6084:
6082:
6080:
6076:
6073:
6071:
6067:
6063:
6059:
6052:
6047:
6045:
6040:
6038:
6033:
6032:
6029:
6017:
6014:
6012:
6009:
6007:
6004:
6002:
5999:
5997:
5994:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5929:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5879:
5877:
5874:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5833:
5831:
5827:
5821:
5818:
5816:
5813:
5811:
5808:
5806:
5803:
5801:
5798:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5778:
5776:
5773:
5771:
5768:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5706:
5703:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5633:
5631:
5628:
5627:
5625:
5621:
5615:
5612:
5610:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5554:
5551:
5549:
5546:
5545:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5479:
5476:
5473:
5470:
5468:
5464:
5461:
5459:
5456:
5452:
5449:
5447:
5444:
5443:
5442:
5439:
5437:
5434:
5430:
5427:
5425:
5422:
5421:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5376:
5374:
5370:
5364:
5361:
5359:
5356:
5354:
5351:
5349:
5346:
5344:
5341:
5339:
5336:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5284:
5281:
5277:
5274:
5272:
5269:
5268:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5245:
5242:
5240:
5237:
5235:
5232:
5231:
5230:
5227:
5225:
5222:
5220:
5217:
5215:
5212:
5210:
5207:
5203:
5200:
5198:
5195:
5194:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5156:
5153:
5151:
5148:
5147:
5146:
5143:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5116:
5113:
5111:
5108:
5104:
5101:
5099:
5096:
5094:
5091:
5090:
5089:
5086:
5084:
5081:
5079:
5076:
5074:
5071:
5069:
5066:
5064:
5061:
5060:
5058:
5054:
5048:
5045:
5043:
5040:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4921:
4918:
4916:
4913:
4912:
4911:
4908:
4904:
4901:
4899:
4896:
4895:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4827:
4824:
4822:
4819:
4818:
4817:
4814:
4812:
4809:
4807:
4804:
4802:
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4783:
4781:
4777:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4731:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4666:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4633:
4630:
4628:
4625:
4624:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4547:
4546:
4543:
4539:
4536:
4534:
4531:
4529:
4526:
4525:
4524:
4521:
4519:
4516:
4512:
4509:
4507:
4504:
4502:
4499:
4498:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4443:
4441:
4437:
4431:
4428:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4395:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4357:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4338:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4285:
4282:
4280:
4277:
4276:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4237:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4198:
4195:
4193:
4190:
4189:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4147:
4146:
4143:
4141:
4138:
4136:
4133:
4129:
4126:
4125:
4124:
4121:
4119:
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4097:
4094:
4092:
4089:
4087:
4084:
4083:
4082:
4079:
4077:
4074:
4070:
4067:
4065:
4062:
4060:
4057:
4055:
4052:
4050:
4047:
4046:
4045:
4042:
4041:
4039:
4035:
4030:
4026:
4022:
4015:
4010:
4008:
4003:
4001:
3996:
3995:
3992:
3978:
3972:
3967:
3963:
3957:
3952:
3948:
3942:
3937:
3936:
3933:
3924:
3919:
3917:
3912:
3910:
3905:
3904:
3901:
3894:
3890:
3889:
3884:
3883:
3878:
3875:
3871:
3868:
3866:
3862:
3858:
3854:
3851:
3850:
3839:
3835:
3831:
3827:
3823:
3819:
3814:
3810:
3806:
3802:
3798:
3794:
3790:
3786:
3782:
3777:
3773:
3769:
3765:
3761:
3757:
3753:
3749:
3745:
3740:
3736:
3732:
3728:
3724:
3720:
3716:
3711:
3707:
3703:
3699:
3693:
3689:
3685:
3678:
3677:
3671:
3667:
3663:
3658:
3653:
3649:
3645:
3641:
3636:
3632:
3628:
3623:
3618:
3614:
3610:
3606:
3601:
3597:
3593:
3588:
3583:
3579:
3575:
3571:
3567:
3563:
3558:
3554:
3550:
3545:
3540:
3536:
3532:
3528:
3524:
3520:
3515:
3514:
3501:
3497:
3492:
3487:
3483:
3479:
3475:
3471:
3467:
3460:
3452:
3448:
3443:
3438:
3434:
3430:
3426:
3419:
3411:
3407:
3403:
3399:
3395:
3391:
3387:
3383:
3376:
3368:
3364:
3359:
3354:
3350:
3346:
3342:
3335:
3327:
3323:
3319:
3315:
3311:
3307:
3303:
3299:
3292:
3284:
3280:
3275:
3270:
3266:
3262:
3258:
3251:
3249:
3240:
3236:
3231:
3226:
3222:
3218:
3214:
3210:
3206:
3199:
3191:
3187:
3182:
3177:
3172:
3167:
3163:
3159:
3155:
3148:
3140:
3136:
3131:
3126:
3121:
3116:
3112:
3108:
3104:
3097:
3089:
3085:
3080:
3075:
3071:
3067:
3063:
3056:
3048:
3044:
3039:
3034:
3029:
3024:
3020:
3016:
3012:
3005:
3003:
2994:
2990:
2986:
2982:
2978:
2974:
2970:
2966:
2959:
2957:
2955:
2946:
2942:
2938:
2934:
2930:
2926:
2922:
2918:
2911:
2903:
2899:
2894:
2889:
2885:
2881:
2877:
2873:
2869:
2862:
2854:
2850:
2846:
2842:
2838:
2834:
2827:
2819:
2815:
2810:
2805:
2801:
2797:
2793:
2789:
2785:
2778:
2770:
2766:
2761:
2756:
2752:
2748:
2744:
2740:
2736:
2729:
2721:
2717:
2713:
2709:
2705:
2698:
2690:
2686:
2681:
2676:
2672:
2668:
2667:Cell Research
2664:
2657:
2649:
2645:
2640:
2635:
2630:
2625:
2621:
2617:
2613:
2606:
2604:
2595:
2591:
2586:
2581:
2577:
2573:
2569:
2565:
2561:
2554:
2546:
2542:
2537:
2532:
2527:
2522:
2518:
2514:
2510:
2503:
2501:
2492:
2488:
2483:
2478:
2474:
2470:
2466:
2459:
2457:
2448:
2444:
2440:
2436:
2431:
2426:
2422:
2418:
2417:FASEB Journal
2414:
2407:
2405:
2396:
2392:
2387:
2382:
2378:
2374:
2370:
2363:
2355:
2351:
2346:
2341:
2337:
2333:
2329:
2325:
2321:
2314:
2306:
2302:
2298:
2294:
2290:
2286:
2282:
2278:
2270:
2268:
2259:
2255:
2251:
2247:
2243:
2239:
2232:
2224:
2220:
2215:
2210:
2206:
2202:
2198:
2191:
2189:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2145:
2143:
2141:
2132:
2128:
2123:
2118:
2114:
2110:
2106:
2099:
2097:
2088:
2084:
2079:
2074:
2070:
2066:
2062:
2058:
2054:
2050:
2046:
2039:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1993:
1989:
1982:
1974:
1970:
1966:
1962:
1958:
1954:
1950:
1946:
1939:
1931:
1927:
1922:
1917:
1913:
1909:
1905:
1901:
1897:
1890:
1882:
1878:
1873:
1868:
1864:
1860:
1856:
1849:
1841:
1837:
1831:
1823:
1819:
1813:
1806:
1802:
1797:
1795:
1793:
1785:
1781:
1776:
1774:
1772:
1767:
1756:
1753:
1750:
1747:
1744:
1741:
1739:
1736:
1733:
1730:
1727:
1724:
1721:
1718:
1715:
1712:
1709:
1705:
1702:
1699:
1696:
1693:
1689:
1686:
1683:
1680:
1679:
1677:
1675:
1665:
1661:
1659:
1655:
1651:
1646:
1642:
1638:
1634:
1630:
1625:
1623:
1619:
1614:
1612:
1608:
1604:
1600:
1596:
1595:cell survival
1592:
1591:cell membrane
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1560:
1556:
1546:
1544:
1540:
1536:
1534:
1530:
1527:CD44 variant
1525:
1523:
1522:endometriosis
1518:
1516:
1513:
1509:
1501:
1497:
1493:
1490:
1486:
1482:
1478:
1477:
1476:
1474:
1464:
1461:
1457:
1447:
1445:
1441:
1437:
1436:transcription
1432:
1430:
1426:
1422:
1417:
1415:
1411:
1407:
1403:
1399:
1394:
1392:
1389:
1385:
1384:hematopoiesis
1381:
1371:
1369:
1365:
1361:
1351:
1349:
1345:
1341:
1338:
1334:
1330:
1326:
1313:
1308:
1304:
1300:
1297:
1293:
1286:
1284:
1281:
1277:
1273:
1269:
1266:
1262:
1258:
1251:
1249:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1216:
1210:
1208:
1204:
1200:
1194:
1190:
1186:
1182:
1178:
1174:
1170:
1167:
1163:
1156:
1154:
1148:
1144:
1140:
1136:
1132:
1128:
1124:
1121:
1115:
1113:
1109:
1105:
1099:
1095:
1091:
1087:
1083:
1079:
1075:
1072:
1070:RefSeq (mRNA)
1068:
1061:
1060:
1055:
1051:
1048:
1042:
1041:
1036:
1032:
1029:
1027:
1023:
1016:
1015:
1010:
1006:
1003:
997:
996:
991:
987:
984:
982:
978:
971:
970:
965:
961:
958:
952:
951:
946:
942:
939:
937:
933:
930:
927:
925:
922:
918:
915:
911:
907:
900:
896:
891:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
814:cell adhesion
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
751:
749:
746:
745:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
660:
658:
655:
654:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
622:
619:
618:
615:
614:Gene ontology
611:
607:
595:
590:
586:
579:
572:
567:
564:
562:
558:
550:
545:
535:body of femur
534:
530:
527:parotid gland
526:
522:
518:
514:
510:
506:
502:
498:
497:
494:
490:
485:
482:
472:
468:
464:
460:
456:
453:skin of thigh
452:
448:
444:
440:
437:parotid gland
436:
435:
432:
428:
423:
420:
419:
416:
414:
410:
408:
407:
403:
402:
399:
397:
393:
389:
385:
381:
373:
368:
364:
360:
355:
345:
341:
334:
327:
321:
314:
306:
302:
298:
293:
289:
284:
280:
272:
267:
263:
259:
254:
244:
240:
233:
226:
220:
213:
209:
203:
199:
195:
190:
186:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
129:
124:
117:
112:
107:
96:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
7012:4-1BB ligand
6924:Fibromodulin
6885:
6629:Mucoproteins
6556:
6528:
6518:
5542:
5462:
5440:
5418:
5265:
5228:
5191:
5144:
5114:
5087:
4909:
4815:
4663:
4392:
4367:
4144:
3976:
3961:
3946:
3887:
3881:
3821:
3817:
3787:(1): 33–45.
3784:
3780:
3747:
3743:
3718:
3714:
3675:
3647:
3643:
3612:
3608:
3572:(1): 51–74.
3569:
3565:
3526:
3522:
3473:
3469:
3459:
3432:
3428:
3418:
3385:
3381:
3375:
3348:
3344:
3334:
3301:
3297:
3291:
3264:
3260:
3212:
3208:
3198:
3161:
3157:
3147:
3110:
3106:
3096:
3069:
3065:
3055:
3018:
3014:
2968:
2964:
2920:
2916:
2910:
2875:
2871:
2861:
2836:
2832:
2826:
2791:
2787:
2777:
2742:
2738:
2728:
2711:
2707:
2697:
2670:
2666:
2656:
2619:
2615:
2570:(1): 51–74.
2567:
2563:
2553:
2516:
2512:
2472:
2468:
2420:
2416:
2376:
2372:
2362:
2327:
2323:
2313:
2280:
2276:
2241:
2237:
2231:
2204:
2200:
2154:
2150:
2112:
2108:
2052:
2048:
2038:
1995:
1991:
1981:
1948:
1944:
1938:
1903:
1899:
1889:
1865:(1): 37–43.
1862:
1858:
1848:
1839:
1830:
1821:
1812:
1671:
1668:Interactions
1662:
1660:expression.
1643:, where the
1637:upregulation
1629:renal cancer
1626:
1615:
1599:cancer cells
1571:angiogenesis
1557:involved in
1552:
1537:
1526:
1519:
1505:
1495:
1470:
1453:
1440:beta-catenin
1433:
1418:
1395:
1377:
1357:
1348:glycoprotein
1336:
1333:glycoprotein
1325:CD44 antigen
1324:
1322:
1245:
1238:NP_001171258
1234:NP_001171257
1230:NP_001171256
1226:NP_001034240
1222:NP_001034239
1207:NP_001189486
1203:NP_001189485
1199:NP_001189484
1196:
1189:NP_001001392
1185:NP_001001391
1181:NP_001001390
1177:NP_001001389
1150:
1143:NM_001177787
1139:NM_001177786
1135:NM_001177785
1131:NM_001039151
1127:NM_001039150
1112:NM_001202557
1108:NM_001202556
1104:NM_001202555
1101:
1094:NM_001001392
1090:NM_001001391
1086:NM_001001390
1082:NM_001001389
1057:
1038:
1012:
993:
967:
948:
928:
923:
698:cell surface
411:
404:
370:102,732,010
357:102,641,486
131:External IDs
74:
18:
7124:Vitronectin
7119:Uteroglobin
7109:Transcortin
7082:Glycophorin
7052:Osteonectin
7037:Lactoferrin
6762:Orosomucoid
6752:Haptoglobin
6351:Desmocollin
3929:PDB gallery
3650:: 177–202.
3021:(9): 1233.
2673:(1): 3–14.
1738:Osteopontin
1714:Fibronectin
1543:bivatuzumab
1406:osteopontin
733:microvillus
503:granulocyte
469:skin of hip
457:human penis
269:35,232,402
256:35,138,882
109:Identifiers
7139:Categories
6952:Syndecan 1
6524:L-selectin
6495:P-selectin
6490:L-selectin
6485:E-selectin
6408:T-cadherin
6329:Desmoglein
6321:Desmosomal
4027:(see also
1859:Immunology
1807:, May 2017
1786:, May 2017
1763:References
1726:Hyaluronan
1708:fibrinogen
1658:metadherin
1603:antibodies
1579:chemokines
1517:patients.
1512:epithelial
1434:CD44 gene
1404:, such as
1391:metastasis
1380:lymphocyte
415:(ortholog)
152:HomoloGene
7062:Protein S
7057:Protein C
7032:Hemopexin
7022:Clusterin
6934:Keratocan
6477:Selectins
6294:Classical
6286:Cadherins
6190:Integrins
6121:L1 family
1743:Selectins
1611:neoplasms
1607:antisense
1587:proteases
1583:receptors
1575:cytokines
1410:collagens
1331:-surface
1248:NP_033981
1173:NP_000601
1153:NM_009851
1078:NM_000610
914:Orthologs
160:GeneCards
6881:Brevican
6876:Neurocan
6871:Aggrecan
6849:Perlecan
6844:Testican
6822:Versican
6817:Biglycan
6777:Ovomucin
6530:integrin
6079:IgSF CAM
4021:Proteins
3870:Articles
3838:12711360
3809:19495756
3801:12511867
3772:14243743
3764:12356905
3735:12168806
3666:19413512
3631:15140204
3596:19594629
3553:21546828
3500:17045821
3470:Immunity
3451:11084024
3410:11548419
3402:10825241
3190:23589287
3139:25572402
3088:12748184
3047:31450747
2993:30019668
2985:12484499
2945:21251441
2902:21116281
2872:Leukemia
2853:12371152
2818:19507218
2769:19200980
2720:14614016
2689:17179981
2648:19004834
2594:19594629
2545:18375392
2491:17135256
2447:23662591
2439:16352650
2395:16565092
2354:11402070
2297:18193058
2258:11023510
2223:15994957
2179:31373618
2171:18234849
2087:37100912
2078:10131557
2030:32747755
1930:10694938
1803:–
1782:–
1674:interact
1545:for v6.
1529:isoforms
1496:in vitro
1429:isoforms
1374:Function
1296:Wikidata
893:Sources:
678:membrane
507:calvaria
6929:Lumican
6812:Decorin
6609:Protein
5829:301–350
5623:251–300
5575:CD240CE
5372:201–250
5056:151–200
4779:101–150
3706:7508842
3587:4306344
3544:3145154
3491:3707630
3367:8576267
3326:8217636
3318:1694723
3283:9573028
3239:1730778
3230:2289325
3181:3663506
3130:4358296
3038:6770463
3015:Cancers
2937:8750182
2893:3072510
2809:2718060
2760:2864724
2639:2613610
2585:4306344
2536:2414264
2345:2192031
2305:5095656
2131:7524735
2057:Bibcode
2021:7612580
2000:Bibcode
1973:8217636
1965:1694723
1881:2454887
1872:1385183
1805:Ensembl
1784:Ensembl
1682:ARHGEF1
1650:KHDRBS1
1589:at the
1402:ligands
1360:isoform
1026:UniProt
981:Ensembl
920:Species
899:QuickGO
708:cytosol
390:pattern
116:Aliases
7002:Avidin
6681:MUC5AC
6392:PCDH19
6387:PCDH15
6258:ITGA2B
6148:Nectin
6126:L1-CAM
6116:PE-CAM
6111:VCAM-1
5836:CD300A
5795:CDw293
5580:CD240D
5441:CD213a
5419:CDw210
5384:CD202b
5358:CDw199
5353:CDw198
5007:CD140b
4439:51–100
3879:Human
3836:
3807:
3799:
3770:
3762:
3733:
3704:
3694:
3664:
3629:
3594:
3584:
3551:
3541:
3498:
3488:
3449:
3408:
3400:
3365:
3324:
3316:
3281:
3237:
3227:
3188:
3178:
3137:
3127:
3086:
3045:
3035:
2991:
2983:
2943:
2935:
2900:
2890:
2851:
2816:
2806:
2767:
2757:
2718:
2687:
2646:
2636:
2592:
2582:
2543:
2533:
2489:
2445:
2437:
2393:
2352:
2342:
2303:
2295:
2256:
2221:
2177:
2169:
2129:
2085:
2075:
2049:Nature
2028:
2018:
1971:
1963:
1928:
1921:395698
1918:
1879:
1869:
1704:Fibrin
1690:, via
1676:with:
1654:YTHDC1
1489:thymus
1485:T cell
1456:homing
1412:, and
1386:, and
1282:search
1280:PubMed
1059:P15379
1040:P16070
936:Entrez
561:BioGPS
511:dermis
140:107269
6965:Other
6896:CSPG5
6891:CSPG4
6745:Other
6736:MUC20
6731:MUC19
6726:MUC17
6721:MUC16
6716:MUC15
6711:MUC13
6706:MUC12
6686:MUC5B
6671:MUC3B
6666:MUC3A
6651:CD164
6638:Mucin
6567:EpCAM
6562:CD146
6539:LFA-1
6535:VLA-4
6508:Other
6463:CDH10
6453:CDH17
6448:CDH16
6443:CDH15
6438:CDH12
6433:CDH11
6382:PCDH1
6262:ITGB3
6244:CD49d
6240:VLA-4
6230:CD11b
6216:CD11c
6202:CD11a
6198:LFA-1
6178:CD155
6173:CADM3
6168:CADM1
6163:PVRL3
6158:PVRL2
6153:PVRL1
6136:NFASC
6131:NRCAM
6087:N-CAM
6016:CD350
6011:CD349
6006:CD344
6001:CD340
5996:CD339
5991:CD338
5986:CD337
5981:CD336
5976:CD335
5971:CD334
5966:CD333
5961:CD332
5956:CD331
5951:CD329
5946:CD328
5941:CD327
5936:CD326
5931:CD325
5926:CD324
5921:CD322
5916:CD321
5911:CD320
5906:CD318
5901:CD317
5896:CD316
5891:CD315
5886:CD314
5881:CD312
5876:CD309
5871:CD307
5866:CD306
5861:CD305
5856:CD304
5851:CD303
5846:CD302
5841:CD301
5820:CD299
5815:CD298
5810:CD297
5805:CD295
5800:CD294
5790:CD292
5785:CD290
5780:CD289
5775:CD288
5770:CD286
5765:CD284
5760:CD283
5755:CD282
5750:CD281
5745:CD280
5740:CD279
5735:CD278
5730:CD276
5725:CD275
5720:CD274
5715:CD273
5710:CD272
5705:CD271
5700:CD269
5695:CD268
5690:CD267
5685:CD266
5680:CD265
5675:CD264
5670:CD263
5665:CD262
5660:CD261
5655:CD258
5650:CD257
5645:CD256
5640:CD254
5635:CD253
5630:CD252
5614:CD249
5609:CD248
5605:CD247
5600:CD246
5595:CD244
5590:CD243
5585:CD241
5570:CD239
5565:CD238
5560:CD236
5543:CD235
5538:CD234
5533:CD233
5528:CD230
5523:CD229
5518:CD228
5513:CD227
5508:CD226
5503:CD225
5498:CD224
5493:CD223
5488:CD222
5483:CD221
5478:CD220
5463:CD218
5458:CD217
5436:CD212
5414:CD209
5409:CD208
5404:CD207
5399:CD206
5394:CD205
5389:CD204
5379:CD201
5363:CD200
5348:CD197
5343:CD196
5338:CD195
5333:CD194
5328:CD193
5323:CD192
5318:CD191
5313:CD186
5308:CD185
5303:CD184
5298:CD183
5293:CD182
5288:CD181
5283:CD180
5266:CD179
5261:CD178
5256:CD177
5251:CD174
5229:CD172
5224:CD171
5219:CD170
5214:CD169
5209:CD168
5192:CD167
5187:CD166
5182:CD164
5177:CD163
5172:CD162
5167:CD161
5162:CD160
5145:CD159
5115:CD158
5110:CD157
5088:CD156
5083:CD155
5078:CD154
5073:CD153
5068:CD152
5063:CD151
5047:CD150
5042:CD148
5037:CD147
5032:CD146
5027:CD144
5022:CD143
5017:CD142
5012:CD141
5002:CD138
4997:CD137
4992:CD136
4987:CD135
4982:CD134
4977:CD133
4972:CD132
4967:CD131
4962:CD130
4957:CD129
4952:CD127
4947:CD126
4942:CD125
4937:CD124
4932:CD123
4927:CD122
4910:CD121
4893:CD120
4888:CD119
4883:CD118
4878:CD117
4873:CD116
4868:CD115
4863:CD114
4858:CD113
4853:CD112
4848:CD111
4843:CD110
4838:CD109
4833:CD108
4816:CD107
4811:CD106
4806:CD105
4801:CD104
4796:CD103
4791:CD102
4786:CD101
4770:CD100
3857:BGMUT
3805:S2CID
3768:S2CID
3680:(PDF)
3406:S2CID
3322:S2CID
3261:Blood
2989:S2CID
2941:S2CID
2443:S2CID
2301:S2CID
2238:Blood
2175:S2CID
2109:Blood
1969:S2CID
1745:, and
1688:Ezrin
1498:with
1450:HCELL
1388:tumor
1364:exons
1327:is a
969:12505
929:Mouse
924:Human
895:Amigo
499:molar
445:vulva
413:Mouse
406:Human
353:Start
288:Mouse
252:Start
248:11p13
185:Human
148:88338
7077:CD43
6992:CD70
6977:ADAM
6886:CD44
6701:MUC8
6696:MUC7
6691:MUC6
6676:MUC4
6661:MUC2
6656:MUC1
6646:CD43
6619:and
6557:CD44
6552:CD24
6519:CD44
6458:CDH9
6428:CDH8
6423:CDH6
6418:CDH5
6413:CDH4
6363:DSC3
6359:DSC2
6355:DSC1
6345:DSG4
6341:DSG3
6337:DSG2
6333:DSG1
6311:CDH3
6306:CDH2
6301:CDH1
6248:CD29
6234:CD18
6220:CD18
6206:CD18
6141:CHL1
6097:ICAM
4765:CD99
4760:CD98
4755:CD97
4750:CD96
4745:CD95
4740:CD94
4735:CD93
4730:CD92
4726:CD91
4721:CD90
4716:CD89
4711:CD88
4706:CD87
4701:CD86
4664:CD85
4659:CD84
4654:CD83
4649:CD82
4644:CD81
4639:CD80
4622:CD79
4617:CD78
4612:CD74
4607:CD73
4602:CD72
4597:CD71
4592:CD70
4587:CD69
4582:CD68
4545:CD66
4523:CD64
4518:CD63
4496:CD62
4491:CD61
4486:CD59
4481:CD58
4476:CD57
4471:CD56
4466:CD55
4461:CD54
4456:CD53
4451:CD52
4446:CD51
4430:CD50
4393:CD49
4388:CD48
4383:CD47
4378:CD46
4373:CD45
4368:CD44
4363:CD43
4336:CD42
4331:CD41
4326:CD40
4321:CD39
4316:CD38
4311:CD37
4306:CD36
4301:CD35
4296:CD34
4291:CD33
4274:CD32
4269:CD31
4264:CD30
4259:CD29
4254:CD28
4249:CD27
4244:CD26
4239:CD25
4234:CD24
4229:CD23
4224:CD22
4219:CD21
4214:CD20
4209:CD19
4204:CD18
4187:CD16
4182:CD15
4177:CD14
4172:CD13
4145:CD11
4140:CD10
4037:1–50
3977:2i83
3962:1uuh
3947:1poz
3888:CD44
3882:CD44
3874:IHOP
3861:NCBI
3834:PMID
3797:PMID
3760:PMID
3731:PMID
3702:PMID
3692:ISBN
3662:PMID
3627:PMID
3592:PMID
3549:PMID
3496:PMID
3447:PMID
3398:PMID
3363:PMID
3314:PMID
3298:Cell
3279:PMID
3235:PMID
3186:PMID
3135:PMID
3084:PMID
3043:PMID
2981:PMID
2933:PMID
2898:PMID
2849:PMID
2814:PMID
2765:PMID
2716:PMID
2685:PMID
2644:PMID
2590:PMID
2541:PMID
2487:PMID
2435:PMID
2391:PMID
2350:PMID
2293:PMID
2254:PMID
2219:PMID
2167:PMID
2127:PMID
2083:PMID
2026:PMID
1961:PMID
1945:Cell
1926:PMID
1877:PMID
1755:CD74
1692:PIP2
1631:and
1620:and
1500:CFSE
1481:CD25
1442:and
1421:gene
1340:gene
1337:CD44
1329:cell
1323:The
396:Bgee
344:Band
305:Chr.
243:Band
202:Chr.
164:CD44
136:OMIM
123:CD44
93:4PZ4
89:4PZ3
85:2I83
81:1UUH
77:1POZ
58:RCSB
55:PDBe
24:CD44
4135:CD9
4123:CD8
4118:CD7
4113:CD6
4108:CD5
4103:CD4
4081:CD3
4076:CD2
4049:a-c
4044:CD1
3872:at
3865:NIH
3855:at
3826:doi
3789:doi
3752:doi
3748:115
3723:doi
3684:doi
3652:doi
3617:doi
3613:122
3582:PMC
3574:doi
3570:230
3539:PMC
3531:doi
3486:PMC
3478:doi
3437:doi
3433:276
3390:doi
3386:184
3353:doi
3349:271
3306:doi
3269:doi
3225:PMC
3217:doi
3213:116
3176:PMC
3166:doi
3162:288
3125:PMC
3115:doi
3111:290
3074:doi
3070:278
3033:PMC
3023:doi
2973:doi
2925:doi
2888:PMC
2880:doi
2841:doi
2804:PMC
2796:doi
2792:119
2755:PMC
2747:doi
2675:doi
2634:PMC
2624:doi
2620:284
2580:PMC
2572:doi
2568:230
2531:PMC
2521:doi
2517:283
2477:doi
2473:282
2425:doi
2381:doi
2377:281
2340:PMC
2332:doi
2328:153
2285:doi
2246:doi
2209:doi
2159:doi
2155:294
2117:doi
2073:PMC
2065:doi
2053:617
2016:PMC
2008:doi
1953:doi
1916:PMC
1908:doi
1867:PMC
1749:Src
1732:Lck
1720:FYN
1656:or
950:960
366:End
265:End
168:OMA
156:508
144:MGI
48:PDB
7141::
6944:HS
6916:KS
6869::
6859:CS
6836:CS
6832:HS
6804:DS
6800:CS
6615::
6611:,
6537:,
6517::
6361:,
6357:,
6343:,
6339:,
6335:,
6103:,
6060::
5607:-
4728:-
4069:1E
4064:1D
4059:1B
4054:1A
4023::
3863:,
3832:.
3822:46
3820:.
3803:.
3795:.
3783:.
3766:.
3758:.
3746:.
3729:.
3719:17
3717:.
3700:.
3690:.
3660:.
3648:11
3646:.
3642:.
3625:.
3611:.
3607:.
3590:.
3580:.
3568:.
3564:.
3547:.
3537:.
3527:18
3525:.
3521:.
3494:.
3484:.
3474:25
3472:.
3468:.
3445:.
3431:.
3427:.
3404:.
3396:.
3384:.
3361:.
3347:.
3343:.
3320:.
3312:.
3302:61
3300:.
3277:.
3265:91
3263:.
3259:.
3247:^
3233:.
3223:.
3211:.
3207:.
3184:.
3174:.
3160:.
3156:.
3133:.
3123:.
3109:.
3105:.
3082:.
3068:.
3064:.
3041:.
3031:.
3019:11
3017:.
3013:.
3001:^
2987:.
2979:.
2969:39
2967:.
2953:^
2939:.
2931:.
2921:26
2919:.
2896:.
2886:.
2876:25
2874:.
2870:.
2847:.
2837:17
2835:.
2812:.
2802:.
2790:.
2786:.
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2710:.
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2642:.
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2618:.
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2602:^
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2511:.
2499:^
2485:.
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2467:.
2455:^
2441:.
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2403:^
2389:.
2375:.
2371:.
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2338:.
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2281:14
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2266:^
2252:.
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2139:^
2125:.
2113:84
2111:.
2107:.
2095:^
2081:.
2071:.
2063:.
2051:.
2047:.
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