443:
184:
24:
621:
113:
486:
InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
476:
InChI=1/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
106:
466:
InChI=1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)
217:
634:
502:
629:
903:
457:
641:
586:
733:; its full chemical name is 3--2-hydroxy-1-propanesulfonate. Both detergents have low light absorbance in the
898:
46:
400:
179:
746:
696:
421:
141:
767:
726:
ulfonate. A related detergent, called CHAPSO, has the same basic chemical structure with an additional
692:
23:
438:
738:
211:
762:
688:
597:
36:
800:
700:
409:
161:
82:
8:
750:
676:
442:
183:
72:
804:
789:"A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis"
823:
788:
893:
869:
864:
847:
828:
742:
328:
294:
268:
246:
848:"Liposome Solubilization and Membrane Protein Reconstitution Using Chaps and Chapso"
362:
859:
818:
808:
730:
704:
530:
239:
846:
Cladera, Josep; Ricaud, Jean-Louis; Verde, Joaquim Villa; DuNach, Mireia (1997).
793:
Proceedings of the
National Academy of Sciences of the United States of America
612:
887:
172:
813:
873:
832:
734:
712:
672:
664:
660:
657:
567:
510:
CC(CCC(=O)NCCC(C)(C)CCCS()(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C
152:
684:
680:
611:
Except where otherwise noted, data are given for materials in their
727:
200:
51:
3-phenanthren-1-yl]pentanamido}propyl)azaniumyl]propane-1-sulfonate
112:
105:
708:
668:
226:
132:
515:
S(=O)(=O)CCC(C)(C)CCCNC(=O)CC(C)4CC32(1((C(O)CC1)C2O)C)C(O)34C
95:
426:
191:
218:
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
845:
707:, which are often sparingly soluble or insoluble in
885:
839:
361:
327:
293:
267:
245:
238:
81:
683:groups; it is structurally similar to certain
786:
441:
182:
160:
863:
822:
812:
741:, which is useful for monitoring ongoing
408:
40:3-{Dimethylazaniumyl}propane-1-sulfonate
437:
216:
886:
703:and is especially useful in purifying
173:
489:Key: UMCMPZBLKLEWAF-BCTGSCMUSA-N
469:Key: UMCMPZBLKLEWAF-UHFFFAOYSA-N
140:
479:Key: UMCMPZBLKLEWAF-BCTGSCMUBQ
229:
199:
13:
718:CHAPS is an abbreviation for 3--1-
667:biological macromolecules such as
14:
915:
865:10.1111/j.1432-1033.1997.00798.x
852:European Journal of Biochemistry
787:Hjelmeland, LM (November 1980).
619:
548:
542:
22:
675:and is zwitterionic due to its
615:(at 25 °C , 100 kPa).
780:
560:
554:
536:
1:
773:
711:solution due to their native
671:. It may be synthesized from
699:detergent in the process of
7:
756:
10:
920:
768:Taurochenodeoxycholic acid
693:taurochenodeoxycholic acid
663:used in the laboratory to
609:
579:
523:
498:
453:
65:
57:
45:
35:
30:
21:
904:Zwitterionic surfactants
739:electromagnetic spectrum
605:−4.32 (predicted)
814:10.1073/pnas.77.11.6368
747:protein-protein binding
695:. It is used as a non-
763:Taurodeoxycholic acid
689:taurodeoxycholic acid
60:3--1-propanesulfonate
47:Systematic IUPAC name
899:Biochemistry methods
701:protein purification
805:1980PNAS...77.6368H
751:UV/Vis spectroscopy
677:quaternary ammonium
575: g·mol
18:
743:chemical reactions
642:Infobox references
16:
705:membrane proteins
650:Chemical compound
648:
647:
580:Surface tension:
422:CompTox Dashboard
114:Interactive image
107:Interactive image
911:
878:
877:
867:
843:
837:
836:
826:
816:
784:
731:functional group
632:
626:
623:
622:
574:
562:
556:
550:
544:
538:
531:Chemical formula
446:
445:
430:
428:
412:
365:
331:
297:
271:
249:
242:
231:
220:
203:
186:
175:
164:
144:
116:
109:
85:
26:
19:
17:CHAPS detergent
15:
919:
918:
914:
913:
912:
910:
909:
908:
884:
883:
882:
881:
844:
840:
799:(11): 6368–70.
785:
781:
776:
759:
651:
644:
639:
638:
637: ?)
628:
624:
620:
616:
589:
572:
559:
553:
547:
541:
533:
519:
516:
511:
506:
505:
494:
491:
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487:
481:
480:
477:
471:
470:
467:
461:
460:
449:
431:
424:
415:
395:
371:
345:
315:
285:
259:
232:
206:
167:
147:
119:
99:
88:
75:
61:
53:
52:
41:
12:
11:
5:
917:
907:
906:
901:
896:
880:
879:
858:(3): 798–804.
838:
778:
777:
775:
772:
771:
770:
765:
758:
755:
737:region of the
713:hydrophobicity
649:
646:
645:
640:
618:
617:
613:standard state
610:
607:
606:
603:
594:
593:
590:
585:
582:
581:
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564:
563:
557:
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478:
475:
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468:
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456:
455:
454:
451:
450:
448:
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439:DTXSID70997059
434:
432:
420:
417:
416:
414:
413:
405:
403:
397:
396:
394:
393:
359:
325:
291:
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243:
235:
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214:
208:
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196:
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169:
168:
166:
165:
157:
155:
149:
148:
146:
145:
137:
135:
129:
128:
125:
124:Abbreviations
121:
120:
118:
117:
110:
102:
100:
93:
90:
89:
87:
86:
78:
76:
71:
68:
67:
63:
62:
59:
55:
54:
50:
49:
43:
42:
39:
33:
32:
28:
27:
9:
6:
4:
3:
2:
916:
905:
902:
900:
897:
895:
892:
891:
889:
875:
871:
866:
861:
857:
853:
849:
842:
834:
830:
825:
820:
815:
810:
806:
802:
798:
794:
790:
783:
779:
769:
766:
764:
761:
760:
754:
752:
748:
744:
740:
736:
732:
729:
725:
721:
716:
714:
710:
706:
702:
698:
694:
690:
686:
682:
678:
674:
670:
666:
662:
659:
655:
643:
636:
631:
614:
608:
604:
602:
601:
596:
595:
591:
588:
584:
583:
578:
571:
569:
566:
565:
535:
532:
528:
527:
522:
513:
508:
507:
504:
497:
483:
473:
463:
462:
459:
452:
444:
440:
436:
435:
433:
423:
419:
418:
411:
407:
406:
404:
402:
399:
398:
391:
387:
383:
379:
375:
369:
364:
360:
357:
353:
349:
343:
339:
335:
330:
326:
323:
319:
313:
309:
305:
301:
296:
292:
289:
283:
279:
275:
270:
266:
263:
257:
253:
248:
244:
241:
237:
236:
234:
228:
224:
223:
219:
215:
213:
210:
209:
202:
198:
197:
195:
193:
190:
189:
185:
181:
178:
176:
174:ECHA InfoCard
171:
170:
163:
159:
158:
156:
154:
151:
150:
143:
139:
138:
136:
134:
131:
130:
126:
123:
122:
115:
111:
108:
104:
103:
101:
97:
92:
91:
84:
80:
79:
77:
74:
70:
69:
64:
56:
48:
44:
38:
34:
29:
25:
20:
855:
851:
841:
796:
792:
782:
723:
719:
717:
658:zwitterionic
653:
652:
599:
389:
385:
381:
377:
373:
367:
355:
351:
347:
341:
337:
333:
321:
317:
311:
307:
303:
299:
287:
281:
277:
273:
261:
255:
251:
142:ChEMBL450950
66:Identifiers
58:Other names
735:ultraviolet
673:cholic acid
524:Properties
272: (),(1
250: (),(5
180:100.129.679
888:Categories
774:References
697:denaturing
687:, such as
685:bile acids
665:solubilize
661:surfactant
568:Molar mass
410:QBP25342AG
153:ChemSpider
94:3D model (
83:75621-03-3
73:CAS Number
37:IUPAC name
681:sulfonate
894:Steroids
757:See also
728:hydroxyl
669:proteins
592:8-10 mM
366: (4
332: (4
329:18397788
298: (4
295:25244640
269:10371606
247:24883538
874:9057848
833:6935651
801:Bibcode
709:aqueous
635:what is
633: (
363:9895216
227:PubChem
872:
831:
824:350285
821:
722:ropane
630:verify
627:
573:614.88
503:SMILES
240:107670
201:C11321
133:ChEMBL
127:CHAPS
31:Names
749:with
656:is a
654:CHAPS
458:InChI
162:96843
96:JSmol
870:PMID
829:PMID
691:and
679:and
598:log
401:UNII
336:),(2
302:),(2
212:MeSH
192:KEGG
860:doi
856:243
819:PMC
809:doi
745:or
587:CMC
427:EPA
388:,16
384:,15
380:,14
354:,16
350:,15
320:,16
280:,11
230:CID
890::
868:.
854:.
850:.
827:.
817:.
807:.
797:77
795:.
791:.
753:.
715:.
546:58
540:32
376:,5
372:(2
370:),
346:14
340:,5
316:15
310:,7
306:,5
286:16
276:,5
260:16
254:,7
876:.
862::
835:.
811::
803::
724:s
720:p
625:N
600:P
561:S
558:7
555:O
552:2
549:N
543:H
537:C
429:)
425:(
392:)
390:S
386:S
382:R
378:R
374:S
368:S
358:)
356:S
352:R
348:R
344:,
342:R
338:S
334:R
324:)
322:S
318:R
314:,
312:S
308:R
304:S
300:R
290:)
288:S
284:,
282:S
278:R
274:S
264:)
262:S
258:,
256:S
252:R
98:)
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