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Calcium ATPase

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during muscle relaxation. In the skeletal muscles the calcium pump in the sarcoplasmic reticulum membrane works in harmony with similar calcium pumps in the plasma membrane. This ensures that the cytosolic concentration of free calcium in resting muscle is below 0.1 μM. The sarcoplasmic and
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Jensen TP, Buckby LE, Empson RM (September 2004). "Expression of plasma membrane Ca2+ ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat".
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endoplasmic reticulum calcium pumps are closely related in structure and mechanism, and both are inhibited by the tumor-promoting agent thapsigargin, which does not affect the plasma membrane Ca pumps.
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Ca concentrations. Since it transports Ca into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the
2154: 185: 461: 570: 1275: 1270: 1255: 943: 270:(Ca) from the cell. It is vital for regulating the amount of Ca within cells. In fact, the PMCA is involved in removing Ca from all 2013: 1578: 1568: 1522: 1239: 1233: 1228: 1206: 1196: 1186: 1153: 1035: 1030: 1020: 801: 741: 647: 1597: 1313: 1217: 1057: 1052: 178: 1543: 652: 145: 1512: 1085: 310: 642: 1306: 1081: 571:"Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3" 2212: 674: 2518: 2103: 139: 2098: 237: 121: 2368: 2120: 407: 126: 2168: 1690: 1485: 1413: 1409: 1386: 1346: 540:"Expression and immunolocalization of plasma membrane calcium ATPase isoforms in human corneal epithelium" 2513: 2090: 190: 114: 2483: 683: 2469: 2456: 2443: 2430: 2417: 2404: 2391: 2353: 2149: 1588: 1359: 1333: 1288: 1048: 1043: 372: 2363: 2317: 2260: 1704: 1399: 1364: 1337: 634: 628: 346:) Ca is normally sequestered (isolated) in a specialized form of endoplasmic reticulum (ER) called 295: 275: 142: 44: 462:"Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps" 66: 2265: 2074: 2037: 1376: 1298: 1804: 1444: 1141: 347: 224: 682: 2286: 2205: 1934: 1842: 2358: 667: 608: 102: 624: 8: 2322: 2139: 1176: 303: 299: 78: 49: 2255: 1720: 595: 433: 2523: 1394: 600: 551: 520: 481: 437: 390: 255: 133: 2301: 2296: 2270: 2198: 1784: 1730: 1712: 590: 582: 512: 473: 429: 321: 516: 2348: 2332: 2245: 2131: 2020: 1834: 1534: 1354: 1165: 991: 687: 660: 586: 477: 355: 291: 287: 259: 2497: 2386: 2327: 359: 263: 161: 965: 2507: 2291: 2250: 1998: 1608: 1169: 981: 283: 2240: 1983: 1956: 1885: 1878: 1861: 1856: 1830: 708: 695: 604: 555: 538:
Talarico EF, Kennedy BG, Marfurt CF, Loeffler KU, Mangini NJ (March 2005).
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into cells, yet it is very important for cells to maintain low
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Jensen TP, Filoteo AG, Knopfel T, Empson RM (February 2007).
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has contracted. The two kinds of calcium ATPase are:
350:(SR). It is a Ca ATPase that transfers Ca from the 418: 459: 2505: 290:; thus it is necessary for the cell to employ 2206: 1314: 668: 472:(1). American Physiological Society: 21–50. 422:Brain Research. Developmental Brain Research 332:Sarcoendoplasmic Reticulum Ca ATPase (SERCA) 274:cells. There is a very large transmembrane 2213: 2199: 1321: 1307: 675: 661: 460:Strehler EE, Zacharias DA (January 2001). 455: 453: 451: 298:(NCX) are together the main regulators of 27: 1064:3.A.3.1.4: H/K transporting, nongastric: 648:Cation transporting ATPase family in Pfam 627:at the U.S. National Library of Medicine 594: 498: 241: 562: 531: 492: 448: 2506: 320:The PMCA is expressed in a variety of 2194: 1302: 656: 501:"Calcium pump of the plasma membrane" 311:P-type primary ion transport ATPases 294:to remove the Ca. The PMCA and the 13: 373:Active transport#Counter-transport 14: 2535: 709:F-, V-, and A-type ATPase (3.A.2) 618: 434:10.1016/j.devbrainres.2004.06.004 2491: 309:The PMCA belongs to a family of 232:Plasma membrane Ca ATPase (PMCA) 221:Plasma membrane Ca ATPase (PMCA) 725:H transporting, mitochondrial: 278:of Ca driving the entry of the 412: 401: 384: 238:Plasma membrane calcium ATPase 1: 517:10.1152/physrev.1991.71.1.129 378: 246:Rendered image of the Ca pump 587:10.1113/jphysiol.2006.123901 478:10.1152/physrev.2001.81.1.21 358:of the SR at the expense of 7: 2220: 2091:Protein-synthesizing GTPase 499:Carafoli E (January 1991). 366: 250:Plasma membrane Ca ATPase ( 10: 2540: 1135:3.A.3.5: Cu transporting: 684:Membrane transport protein 607:. 17170045. Archived from 335: 235: 2377: 2369:Michaelis–Menten kinetics 2341: 2310: 2279: 2228: 2150:Guanylate-binding protein 2129: 2088: 1828: 1702: 1689: 1654: 1606: 1587: 1533: 1453: 1432: 1425: 1408: 1385: 1345: 1334:acid anhydride hydrolases 1284: 980: 964: 830:H transporting, lysosomal 820: 716: 707: 575:The Journal of Physiology 184: 172: 160: 155: 151: 132: 120: 108: 96: 84: 72: 60: 55: 43: 38: 26: 21: 2261:Diffusion-limited enzyme 1705:Heterotrimeric G protein 1400:Phosphoadenylylsulfatase 629:Medical Subject Headings 296:sodium calcium exchanger 276:electrochemical gradient 1377:Thiamine-triphosphatase 643:Overview at utoronto.ca 2519:Transmembrane proteins 611:on September 27, 2007. 393:Molecule of the Month 348:sarcoplasmic reticulum 266:that serves to remove 247: 225:Sarcoplasmic reticulum 2354:Eadie–Hofstee diagram 2287:Allosteric regulation 2132:Polymerization motors 1843:Rho family of GTPases 505:Physiological Reviews 466:Physiological Reviews 245: 2364:Lineweaver–Burk plot 2140:dynamin superfamily 1238:Class VI, type 11: 354:of the cell to the 304:extracellular space 2514:Transport proteins 2323:Enzyme superfamily 2256:Enzyme promiscuity 1222:Class V, type 10: 1211:Class II, type 9: 315:aspartyl phosphate 248: 2479: 2478: 2188: 2187: 2184: 2183: 1685: 1684: 1650: 1649: 1395:Adenylylsulfatase 1296: 1295: 1185:Class I, type 8: 992:Na/K transporting 976: 975: 286:of Ca for proper 256:transport protein 227:Ca ATPase (SERCA) 200: 199: 196: 195: 115:metabolic pathway 2531: 2496: 2495: 2487: 2359:Hanes–Woolf plot 2302:Enzyme activator 2297:Enzyme inhibitor 2271:Enzyme catalysis 2215: 2208: 2201: 2192: 2191: 1700: 1699: 1430: 1429: 1423: 1422: 1323: 1316: 1309: 1300: 1299: 1289:ATPase disorders 1160:Other/ungrouped: 714: 713: 677: 670: 663: 654: 653: 613: 612: 598: 566: 560: 559: 544:Molecular Vision 535: 529: 528: 496: 490: 489: 457: 446: 445: 416: 410: 405: 399: 388: 324:, including the 153: 152: 31: 19: 18: 16:Class of enzymes 2539: 2538: 2534: 2533: 2532: 2530: 2529: 2528: 2504: 2503: 2502: 2490: 2482: 2480: 2475: 2387:Oxidoreductases 2373: 2349:Enzyme kinetics 2337: 2333:List of enzymes 2306: 2275: 2246:Catalytic triad 2224: 2219: 2189: 2180: 2125: 2084: 1835:Ras superfamily 1824: 1808: 1788: 1734: 1724: 1716: 1681: 1646: 1602: 1583: 1529: 1486:Plasma membrane 1449: 1404: 1381: 1355:Pyrophosphatase 1341: 1327: 1297: 1292: 1280: 1177:Mg transporting 1090:Ca transporting 972: 971:found in Archea 960: 816: 703: 681: 621: 616: 581:(Pt 1): 85–99. 567: 563: 536: 532: 497: 493: 458: 449: 417: 413: 406: 402: 389: 385: 381: 369: 340: 334: 288:cell signalling 260:plasma membrane 240: 234: 209:that transfers 34: 17: 12: 11: 5: 2537: 2527: 2526: 2521: 2516: 2501: 2500: 2477: 2476: 2474: 2473: 2460: 2447: 2434: 2421: 2408: 2395: 2381: 2379: 2375: 2374: 2372: 2371: 2366: 2361: 2356: 2351: 2345: 2343: 2339: 2338: 2336: 2335: 2330: 2325: 2320: 2314: 2312: 2311:Classification 2308: 2307: 2305: 2304: 2299: 2294: 2289: 2283: 2281: 2277: 2276: 2274: 2273: 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1584: 1582: 1581: 1576: 1571: 1566: 1561: 1556: 1551: 1546: 1540: 1538: 1531: 1530: 1528: 1527: 1526: 1525: 1520: 1510: 1509: 1508: 1503: 1498: 1493: 1483: 1482: 1481: 1476: 1471: 1460: 1458: 1451: 1450: 1448: 1447: 1442: 1436: 1434: 1433:Cu++ (3.6.3.4) 1427: 1420: 1406: 1405: 1403: 1402: 1397: 1391: 1389: 1383: 1382: 1380: 1379: 1374: 1369: 1368: 1367: 1362: 1351: 1349: 1343: 1342: 1326: 1325: 1318: 1311: 1303: 1294: 1293: 1285: 1282: 1281: 1279: 1278: 1273: 1268: 1263: 1258: 1252: 1247: 1242: 1236: 1231: 1226: 1220: 1215: 1209: 1204: 1199: 1194: 1189: 1183: 1173: 1172: 1162: 1161: 1157: 1156: 1145: 1144: 1139: 1132: 1131: 1126: 1121: 1116: 1111: 1106: 1101: 1096: 1069: 1068: 1061: 1060: 1055: 1049:H/K exchanging 1046: 1039: 1038: 1033: 1028: 1023: 1018: 1013: 1008: 1003: 998: 987: 985: 978: 977: 974: 973: 970: 968: 962: 961: 959: 958: 952: 951: 946: 941: 936: 931: 926: 921: 916: 911: 906: 901: 896: 891: 886: 881: 876: 871: 866: 861: 856: 851: 846: 841: 836: 826: 824: 818: 817: 815: 814: 809: 804: 799: 794: 789: 784: 779: 774: 769: 764: 759: 754: 749: 744: 739: 734: 729: 722: 720: 711: 705: 704: 680: 679: 672: 665: 657: 651: 650: 645: 640: 632: 625:Calcium+ATPase 620: 619:External links 617: 615: 614: 561: 530: 491: 447: 411: 400: 382: 380: 377: 376: 375: 368: 365: 360:ATP hydrolysis 336:Main article: 333: 330: 317:intermediate. 284:concentrations 236:Main article: 233: 230: 229: 228: 222: 198: 197: 194: 193: 188: 182: 181: 176: 170: 169: 164: 158: 157: 149: 148: 137: 130: 129: 124: 118: 117: 112: 106: 105: 100: 94: 93: 88: 82: 81: 76: 70: 69: 64: 58: 57: 53: 52: 47: 41: 40: 36: 35: 33:Calcium ATPase 32: 24: 23: 22:Calcium ATPase 15: 9: 6: 4: 3: 2: 2536: 2525: 2522: 2520: 2517: 2515: 2512: 2511: 2509: 2499: 2494: 2489: 2488: 2485: 2471: 2467: 2466: 2461: 2458: 2454: 2453: 2448: 2445: 2441: 2440: 2435: 2432: 2428: 2427: 2422: 2419: 2415: 2414: 2409: 2406: 2402: 2401: 2396: 2393: 2389: 2388: 2383: 2382: 2380: 2376: 2370: 2367: 2365: 2362: 2360: 2357: 2355: 2352: 2350: 2347: 2346: 2344: 2340: 2334: 2331: 2329: 2328:Enzyme family 2326: 2324: 2321: 2319: 2316: 2315: 2313: 2309: 2303: 2300: 2298: 2295: 2293: 2292:Cooperativity 2290: 2288: 2285: 2284: 2282: 2278: 2272: 2269: 2267: 2264: 2262: 2259: 2257: 2254: 2252: 2251:Oxyanion hole 2249: 2247: 2244: 2242: 2239: 2237: 2234: 2233: 2231: 2227: 2223: 2216: 2211: 2209: 2204: 2202: 2197: 2196: 2193: 2177: 2174: 2170: 2167: 2165: 2161: 2158: 2156: 2153: 2151: 2148: 2146: 2143: 2142: 2141: 2138: 2137: 2135: 2133: 2128: 2122: 2119: 2115: 2112: 2110: 2107: 2105: 2102: 2101: 2100: 2097: 2096: 2094: 2092: 2087: 2081: 2078: 2076: 2073: 2071: 2068: 2066: 2063: 2059: 2056: 2054: 2051: 2049: 2046: 2044: 2041: 2040: 2039: 2036: 2032: 2029: 2027: 2024: 2023: 2022: 2019: 2015: 2012: 2010: 2007: 2005: 2002: 2001: 2000: 1996: 1995: 1990: 1987: 1985: 1982: 1981: 1980: 1977: 1973: 1970: 1968: 1965: 1963: 1960: 1959: 1958: 1955: 1951: 1948: 1946: 1943: 1941: 1938: 1937: 1936: 1933: 1931: 1928: 1924: 1921: 1919: 1916: 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ATPase 979: 969: 967: 963: 957: 954: 953: 950: 947: 945: 942: 940: 937: 935: 932: 930: 927: 925: 922: 920: 917: 915: 912: 910: 907: 905: 902: 900: 897: 895: 892: 890: 887: 885: 882: 880: 877: 875: 872: 870: 867: 865: 862: 860: 857: 855: 852: 850: 847: 845: 842: 840: 837: 835: 831: 828: 827: 825: 823: 819: 813: 810: 808: 805: 803: 800: 798: 795: 793: 790: 788: 785: 783: 780: 778: 775: 773: 770: 768: 765: 763: 760: 758: 755: 753: 750: 748: 745: 743: 740: 738: 735: 733: 730: 728: 724: 723: 721: 719: 715: 712: 710: 706: 701: 697: 693: 689: 685: 678: 673: 671: 666: 664: 659: 658: 655: 649: 646: 644: 641: 639: 636: 633: 630: 626: 623: 622: 610: 606: 602: 597: 592: 588: 584: 580: 576: 572: 565: 557: 553: 549: 545: 541: 534: 526: 522: 518: 514: 511:(1): 129–53. 510: 506: 502: 495: 487: 483: 479: 475: 471: 467: 463: 456: 454: 452: 443: 439: 435: 431: 428:(2): 129–36. 427: 423: 415: 409: 404: 398: 397: 392: 387: 383: 374: 371: 370: 364: 361: 357: 353: 349: 345: 342:In myocytes ( 339: 329: 327: 323: 318: 316: 313:that form an 312: 307: 305: 301: 300:intracellular 297: 293: 289: 285: 281: 277: 273: 269: 265: 261: 257: 253: 244: 239: 226: 223: 220: 219: 218: 216: 212: 208: 205:is a form of 204: 192: 189: 187: 183: 180: 177: 175: 171: 168: 165: 163: 159: 154: 150: 147: 144: 141: 138: 135: 131: 128: 125: 123: 119: 116: 113: 111: 107: 104: 101: 99: 95: 92: 91:NiceZyme view 89: 87: 83: 80: 77: 75: 71: 68: 65: 63: 59: 54: 51: 48: 46: 42: 37: 30: 25: 20: 2465:Translocases 2462: 2449: 2436: 2423: 2410: 2400:Transferases 2397: 2384: 2241:Binding site 1978: 1912: 1868: 1846: 1831:Small GTPase 1454: 1445:Wilson/ATP7B 1440:Menkes/ATP7A 1286: 1089: 1073: 696:ATP synthase 609:the original 578: 574: 564: 547: 543: 533: 508: 504: 494: 469: 465: 425: 421: 414: 403: 396:Calcium pump 394: 386: 344:muscle cells 341: 319: 308: 251: 249: 202: 201: 79:BRENDA entry 2236:Active site 2155:Mitofusin-1 2130:3.6.5.5-6: 2099:Prokaryotic 1148:3.A.3.8.8: 1042:3.A.3.1.2: 990:3.A.3.1.1: 408:nlm.nih.gov 67:IntEnz view 39:Identifiers 2508:Categories 2439:Isomerases 2413:Hydrolases 2280:Regulation 2121:Eukaryotic 1754:Transducin 1591:(3.6.3.10) 1330:Hydrolases 822:H (V-type) 718:H (F-type) 700:TC 3A2-3A3 550:: 169–78. 379:References 272:eukaryotic 136:structures 103:KEGG entry 2318:EC number 2089:3.6.5.3: 1829:3.6.5.2: 1771:Gustducin 1703:3.6.5.1: 1537:(3.6.3.9) 1457:(3.6.3.8) 1360:Inorganic 1287:see also 1254:type 13: 1072:3.A.3.2: 688:ion pumps 292:ion pumps 203:Ca ATPase 56:Databases 2524:EC 7.2.2 2342:Kinetics 2266:Cofactor 2229:Activity 1365:Thiamine 1150:flippase 966:A-ATPase 949:ATP6V0E1 939:ATP6V0D2 934:ATP6V0D1 919:ATP6V0A4 914:ATP6V0A2 909:ATP6V0A1 899:ATP6V1G3 894:ATP6V1G2 889:ATP6V1G1 879:ATP6V1E2 874:ATP6V1E1 864:ATP6V1C2 859:ATP6V1C1 854:ATP6V1B2 849:ATP6V1B1 638:7.2.2.10 605:17170045 556:15765049 486:11152753 442:15351500 367:See also 213:after a 207:P-ATPase 191:proteins 179:articles 167:articles 140:RCSB PDB 50:7.2.2.10 2498:Biology 2452:Ligases 2222:Enzymes 2176:Tubulin 2145:Dynamin 1997:other: 1677:Katanin 1667:Kinesin 1642:ATP13A3 1637:ATP13A2 1372:Apyrase 1276:ATP13A5 1271:ATP13A4 1266:ATP13A3 1261:ATP13A2 1256:ATP13A1 984:(3.A.3) 944:ATP6V0E 929:ATP6V0C 924:ATP6V0B 904:ATP6V1H 884:ATP6V1F 869:ATP6V1D 844:ATP6V1A 839:ATP6AP2 834:ATP6AP1 692:ATPases 596:2075377 525:1986387 352:cytosol 322:tissues 268:calcium 258:in the 254:) is a 211:calcium 127:profile 110:MetaCyc 2484:Portal 2426:Lyases 2053:ARL13B 1913:RhoBTB 1807:α12/13 1695:GTPase 1672:Myosin 1662:Dynein 1632:ATP12A 1627:ATP11B 1622:ATP10A 1617:ATP8B1 1607:Other 1579:ATP1B4 1574:ATP1B3 1569:ATP1B2 1564:ATP1B1 1559:ATP1A4 1554:ATP1A3 1549:ATP1A2 1544:ATP1A1 1535:Na+/K+ 1523:ATP2C2 1518:ATP2C1 1506:ATP2B4 1501:ATP2B3 1496:ATP2B2 1491:ATP2B1 1479:ATP2A3 1474:ATP2A2 1469:ATP2A1 1418:ATPase 1250:ATP11C 1245:ATP11B 1240:ATP11A 1234:ATP10D 1229:ATP10B 1224:ATP10A 1207:ATP8B4 1202:ATP8B3 1197:ATP8B2 1192:ATP8B1 1187:ATP8A1 1154:ATP8A2 1129:ATP2C1 1124:ATP2B4 1119:ATP2B3 1114:ATP2B2 1109:ATP2B1 1104:ATP2A3 1099:ATP2A2 1094:ATP2A1 1066:ATP12A 1036:ATP1G1 1031:ATP1B4 1026:ATP1B3 1021:ATP1B2 1016:ATP1B1 1011:ATP1A4 1006:ATP1A3 1001:ATP1A2 996:ATP1A1 956:TCIRG1 802:ATP5L2 792:ATP5J2 772:ATP5G3 767:ATP5G2 762:ATP5G1 757:ATP5F1 742:ATP5C2 737:ATP5C1 727:ATP5A1 631:(MeSH) 603:  593:  554:  523:  484:  440:  215:muscle 174:PubMed 156:Search 146:PDBsum 86:ExPASy 74:BRENDA 62:IntEnz 45:EC no. 2378:Types 2109:EF-Tu 2048:SAR1B 2031:RAB27 2026:RAB23 1979:RhoDF 1869:RhoUV 1852:CDC42 1847:Cdc42 1833:> 1818:GNA13 1813:GNA12 1798:GNA11 1787:αq/11 1776:GNAT3 1764:GNAT2 1759:GNAT1 1749:GNAI3 1744:GNAI2 1739:GNAI1 1691:3.6.5 1655:3.6.4 1598:ATP4A 1589:H+/K+ 1464:SERCA 1426:3.6.3 1410:3.6.3 1387:3.6.2 1347:3.6.1 1218:ATP9B 1213:ATP9A 1142:ATP7B 1137:ATP7A 1078:SERCA 1058:ATP4B 1053:ATP4A 812:ATP5S 807:ATP5O 797:ATP5L 787:ATP5J 782:ATP5I 777:ATP5H 752:ATP5E 747:ATP5D 732:ATP5B 356:lumen 338:SERCA 326:brain 264:cells 122:PRIAM 2470:list 2463:EC7 2457:list 2450:EC6 2444:list 2437:EC5 2431:list 2424:EC4 2418:list 2411:EC3 2405:list 2398:EC2 2392:list 2385:EC1 2169:OPA1 2162:and 2114:EF-G 2104:IF-2 2070:Rheb 2058:ARL6 2043:ARF6 2014:NRAS 2009:KRAS 2004:HRAS 1989:RhoD 1984:RhoF 1930:RhoH 1906:RhoG 1891:Rac1 1879:RhoV 1874:RhoU 1857:TC10 1793:GNAQ 1513:SPCA 1340:3.6) 1181:ATP3 1166:Na/K 1088:) / 1086:SPCA 1082:PMCA 601:PMID 552:PMID 521:PMID 482:PMID 438:PMID 252:PMCA 186:NCBI 143:PDBe 98:KEGG 2164:MX2 2160:MX1 2080:RGK 2075:Rap 2065:Ran 2038:Arf 2021:Rab 1999:Ras 1957:Rnd 1935:Rho 1886:Rac 1862:TCL 1723:olf 1455:Ca+ 1044:H/K 591:PMC 583:doi 579:579 513:doi 474:doi 430:doi 426:152 391:PDB 280:ion 262:of 162:PMC 134:PDB 2510:: 1845:: 1733:αi 1715:αs 1693:: 1416:: 1338:EC 1332:: 1179:: 1168:– 1152:: 1092:: 1084:, 1080:, 1074:Ca 1051:: 994:: 832:: 694:/ 690:, 686:: 635:EC 599:. 589:. 577:. 573:. 548:11 546:. 542:. 519:. 509:71 507:. 503:. 480:. 470:81 468:. 464:. 450:^ 436:. 424:. 328:. 306:. 2486:: 2472:) 2468:( 2459:) 2455:( 2446:) 2442:( 2433:) 2429:( 2420:) 2416:( 2407:) 2403:( 2394:) 2390:( 2214:e 2207:t 2200:v 1972:3 1967:2 1962:1 1950:C 1945:B 1940:A 1923:2 1918:1 1901:3 1896:2 1805:G 1785:G 1731:G 1721:G 1713:G 1414:4 1412:- 1336:( 1322:e 1315:t 1308:v 1170:H 1076:( 702:) 698:( 676:e 669:t 662:v 585:: 558:. 527:. 515:: 488:. 476:: 444:. 432::

Index


EC no.
7.2.2.10
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB
RCSB PDB
PDBe
PDBsum
PMC
articles
PubMed
articles
NCBI
proteins
P-ATPase
calcium
muscle
Sarcoplasmic reticulum
Plasma membrane calcium ATPase

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