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Calcium channel

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is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials. However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. L-type calcium channel blockers selectively inhibit these action potentials
665:. Increased calcium conductance in the neurons leads to increased depolarization and excitability. This leads to a greater predisposition to epileptic episodes. Calcium channel blockers reduce the neuronal calcium conductance and reduce the likelihood of experiencing epileptic attacks. 196:
Skeletal muscle, smooth muscle, bone (osteoblasts), ventricular myocytes** (responsible for prolonged action potential in cardiac cell; also termed DHP receptors), dendrites and dendritic spines of cortical neurons
43:. Other calcium channels can also be regulated by both voltage and ligands to provide precise control over ion flow. Some cation channels allow calcium as well as other cations to pass through the membrane. 694: 2004: 2914: 2649: 1901: 1834: 549: 1237: 65:
The following tables explain gating, gene, location and function of different types of calcium channels, both voltage and ligand-gated.
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The Weiss Lab is investigating the molecular and cellular mechanisms underlying human diseases caused by dysfunction of ion channels
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There are several cation channel families that allow positively charged ions including calcium to pass through. These include
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Putney JW, Steinckwich-Besançon N, Numaga-Tomita T, Davis FM, Desai PN, D'Agostin DM, et al. (June 2017).
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channels, found in mammalian sperm, are one example of this as they are voltage gated and ligand regulated.
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Wu, Jianping; Yan, Zhen; Li, Zhangqiang; Yan, Chuangye; Lu, Shan; Dong, Mengqiu; Yan, Nieng (2015-12-18).
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Katz AM (September 1986). "Pharmacology and mechanisms of action of calcium-channel blockers".
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Textbook of Ion Channels Volume II: Properties, Function, and Pharmacology of the Superfamilies
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in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypertension.
576: 527: 488: 347: 313: 304: 259: 255: 211: 202: 120: 824:"TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene & protein" 3451: 1206: 572: 523: 484: 473: 1188: 1304: 8: 2771: 1647: 1294: 1104: 1079: 1033: 978: 930: 905: 881: 848: 674: 637:
Depiction of binding sites of various antagonistic drugs in the L-type calcium channel.
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a manually curated database of protein-protein interactions for mammalian TRP channels
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Striggow F, Ehrlich BE (August 1996). "Ligand-gated calcium channels inside and out".
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across cell membranes. Calcium channels can also be used to release calcium ions as
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and increased intracellular calcium (Calcium Induced Calcium Release - CICR)
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NAADP-activated calcium transport across endosomal/lysosomal membranes
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within the cell, affecting downstream signaling pathways.  
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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Calcium channels can participate in the creation of
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Ion channel complex through which calcium ions pass
906:"The functions of store-operated calcium channels" 3443: 3386: 847:Prakriya, Murali; Lewis, Richard S. (Oct 2015). 802:. Edinburgh: Churchill Livingstone. p. 54. 1078:Zamponi GW, Lory P, Perez-Reyes E (July 2010). 548:Nicotinic acid adenine dinucleotide phosphate ( 953:Zheng, Jie; Trudeau, Matthew C. (2023-06-06). 1214: 1148:IUPHAR Database of Receptors and Ion Channels 846: 493:Releases calcium from ER/SR in response to IP 952: 590:Provides calcium signaling to the cytoplasm 607:Transient Receptor Potential (TRP) channels 597:Non-selective Channels Permeable to Calcium 1221: 1207: 995: 1805: 1250: 1191:at the U.S. National Library of Medicine 1103: 929: 880: 761: 793: 791: 789: 632: 3374: 1593: 743: 3444: 611:Cyclic nucleotide-gated (CNG) channels 31:ions. It is sometimes synonymous with 27:which shows selective permeability to 3373: 2558: 1804: 1592: 1249: 1202: 959:(1 ed.). Boca Raton: CRC Press. 786: 1050: 797: 746:"A Crash Course in Calcium Channels" 705: 677: – Use of calcium by organisms. 60: 2587:Calcium-activated chloride channels 123:("Long-Lasting" AKA "DHP Receptor") 13: 1657:Amiloride-sensitive cation channel 429:receptor-operated calcium channels 14: 3478: 2559: 1124: 849:"Store-Operated Calcium Channels" 744:Zamponi, Gerald W. (2017-12-20). 81:voltage-operated calcium channels 1053:Journal of Clinical Hypertension 68: 3180:Voltage-dependent anion channel 1273:Inositol trisphosphate receptor 1071: 1044: 713:Current Opinion in Cell Biology 628: 533:Calcium-induced calcium release 422: 250:and peripheral nervous system. 3202:General bacterial porin family 989: 946: 897: 840: 816: 737: 688: 310:intermediate-voltage-activated 1: 725:10.1016/S0955-0674(96)80025-1 681: 649:. In most areas of the body, 558:endosomal/lysosomal membranes 75:voltage-gated calcium channel 33:voltage-gated calcium channel 1144:"Voltage-Gated Ion Channels" 922:10.1016/j.bbamcr.2016.11.028 763:10.1021/acschemneuro.7b00415 700:Dorland's Medical Dictionary 264:HVA (high voltage activated) 208:HVA (high-voltage-activated) 126:HVA (high voltage activated) 7: 668: 10: 3483: 3462:Integral membrane proteins 2621:Chloride Channel Accessory 1230:Membrane transport protein 865:10.1152/physrev.00020.2014 72: 3427: 3382: 3369: 3210: 3099: 2895: 2793: 2769: 2571: 2567: 2554: 2177: 2082: 1947: 1820: 1816: 1800: 1687: 1646: 1616:Epithelial sodium channel 1608: 1604: 1588: 1320: 1265: 1261: 1245: 1096:10.1007/s00424-009-0772-x 750:ACS Chemical Neuroscience 615:Acid-sensing ion channels 511:dihydropyridine receptors 404:neurons, cells that have 1533:Cation channels of sperm 1193:Medical Subject Headings 659:calcium channel blockers 643:calcium channel blockers 1014:10.1126/science.aad2395 567:store-operated channels 638: 348:T-type calcium channel 305:R-type calcium channel 260:Q-type calcium channel 256:P-type calcium channel 203:N-type calcium channel 121:L-type calcium channel 1609:Constitutively active 965:10.1201/9781003096276 853:Physiological Reviews 636: 353:low-voltage-activated 1059:(3 Suppl): 28S–37S. 579:depletion of calcium 293:in the cerebellum / 3376:By gating mechanism 582:ORAI1, ORAI2, ORAI3 481:ITPR1, ITPR2, ITPR3 114:Most often found in 109:Associated subunits 104:subunit (gene name) 2903:TRP cation channel 2801:CNG cation channel 2084:Tandem pore domain 1295:Ryanodine receptor 675:Calcium in biology 661:are used to treat 645:are used to treat 639: 506:Ryanodine receptor 205:("Neural"/"Non-L") 37:membrane potential 3457:Electrophysiology 3439: 3438: 3423: 3422: 3419: 3418: 3411:Stretch-activated 3388:Ion channel class 3365: 3364: 3361: 3360: 2550: 2549: 2546: 2545: 1822:Calcium-activated 1810:Potassium channel 1796: 1795: 1792: 1791: 1584: 1583: 1580: 1579: 1008:(6267): aad2395. 974:978-1-003-09627-6 809:978-0-443-07145-4 756:(12): 2583–2585. 695:"calcium channel" 594: 593: 420: 419: 61:Comparison tables 52:second messengers 48:action potentials 3474: 3467:Calcium channels 3384: 3383: 3371: 3370: 2579:Chloride channel 2569: 2568: 2556: 2555: 1949:Inward-rectifier 1818: 1817: 1802: 1801: 1606: 1605: 1590: 1589: 1560:Two-pore channel 1263: 1262: 1247: 1246: 1223: 1216: 1209: 1200: 1199: 1189:Calcium+Channels 1185: 1183: 1182: 1173:. Archived from 1162: 1160: 1159: 1139: 1118: 1117: 1107: 1075: 1069: 1068: 1048: 1042: 1041: 993: 987: 986: 950: 944: 943: 933: 901: 895: 894: 884: 859:(4): 1383–1436. 844: 838: 837: 835: 834: 820: 814: 813: 798:Rang HP (2003). 795: 784: 783: 765: 741: 735: 709: 703: 692: 544:Two-pore channel 520:RYR1, RYR2, RYR3 434: 433: 408:activity, bone ( 342:, other neurons 333:δ, β, possibly γ 291:Purkinje neurons 287:δ, β, possibly γ 86: 85: 3482: 3481: 3477: 3476: 3475: 3473: 3472: 3471: 3442: 3441: 3440: 3435: 3415: 3378: 3357: 3206: 3105: 3095: 2891: 2789: 2765: 2563: 2542: 2456: 2333: 2190: 2173: 2078: 2042: 2012: 1968: 1960: 1943: 1897: 1812: 1788: 1761: 1700: 1683: 1642: 1600: 1576: 1459: 1431: 1418: 1405: 1385: 1372: 1337: 1316: 1257: 1255:Calcium channel 1241: 1227: 1180: 1178: 1167:"TRIP Database" 1165: 1157: 1155: 1142: 1132:"The Weiss Lab" 1130: 1127: 1122: 1121: 1084:Pflügers Archiv 1076: 1072: 1049: 1045: 994: 990: 975: 951: 947: 902: 898: 845: 841: 832: 830: 828:www.uniprot.org 822: 821: 817: 810: 796: 787: 742: 738: 710: 706: 693: 689: 684: 671: 631: 599: 586:plasma membrane 496: 477: 468: 425: 390: 385: 375: 370: 360: 332: 317: 286: 271: 246:Throughout the 242: 238: 234: 230: 215: 192: 177: 172: 162: 148: 143: 133: 103: 77: 71: 63: 21:calcium channel 17: 12: 11: 5: 3480: 3470: 3469: 3464: 3459: 3454: 3437: 3436: 3428: 3425: 3424: 3421: 3420: 3417: 3416: 3414: 3413: 3408: 3403: 3398: 3392: 3390: 3380: 3379: 3367: 3366: 3363: 3362: 3359: 3358: 3356: 3355: 3350: 3349: 3348: 3347: 3346: 3341: 3336: 3328: 3327: 3326: 3321: 3316: 3308: 3307: 3306: 3301: 3296: 3291: 3286: 3281: 3276: 3268: 3267: 3266: 3261: 3256: 3251: 3246: 3241: 3236: 3222: 3220: 3208: 3207: 3205: 3204: 3199: 3198: 3197: 3192: 3187: 3177: 3176: 3175: 3170: 3165: 3160: 3155: 3150: 3145: 3140: 3135: 3130: 3119: 3117: 3103: 3097: 3096: 3094: 3093: 3092: 3091: 3086: 3081: 3076: 3071: 3066: 3056: 3055: 3054: 3049: 3039: 3034: 3033: 3032: 3027: 3022: 3012: 3011: 3010: 3005: 3000: 2995: 2990: 2985: 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1598:Sodium channel 1586: 1585: 1582: 1581: 1578: 1577: 1575: 1574: 1573: 1572: 1567: 1557: 1556: 1555: 1550: 1545: 1540: 1529: 1528: 1527: 1526: 1521: 1516: 1511: 1501: 1500: 1499: 1494: 1489: 1484: 1474: 1473: 1472: 1467: 1457: 1452: 1451: 1450: 1449: 1444: 1439: 1429: 1421: 1416: 1408: 1403: 1395: 1394: 1393: 1383: 1375: 1370: 1362: 1361: 1360: 1355: 1350: 1345: 1335: 1326: 1324: 1318: 1317: 1315: 1314: 1313: 1312: 1307: 1302: 1292: 1291: 1290: 1285: 1280: 1269: 1267: 1259: 1258: 1243: 1242: 1226: 1225: 1218: 1211: 1203: 1197: 1196: 1186: 1163: 1140: 1126: 1125:External links 1123: 1120: 1119: 1090:(2): 395–403. 1070: 1043: 988: 973: 945: 916:(6): 900–906. 896: 839: 815: 808: 785: 736: 719:(4): 490–495. 704: 686: 685: 683: 680: 679: 678: 670: 667: 651:depolarization 630: 627: 598: 595: 592: 591: 588: 583: 580: 571:indirectly by 569: 563: 562: 559: 556: 553: 546: 540: 539: 530: 521: 518: 508: 502: 501: 494: 491: 482: 479: 475: 471: 466: 461: 460: 455: 450: 445: 440: 432: 431: 424: 421: 418: 417: 402: 400: 388: 373: 358: 354: 351: 344: 343: 334: 330: 327: 315: 311: 308: 301: 300: 288: 284: 281: 269: 265: 262: 258:("Purkinje") / 252: 251: 244: 240: 236: 232: 228: 225: 213: 209: 206: 199: 198: 194: 190: 187: 175: 160: 146: 131: 127: 124: 117: 116: 111: 106: 101: 97: 92: 84: 83: 73:Main article: 70: 67: 62: 59: 15: 9: 6: 4: 3: 2: 3479: 3468: 3465: 3463: 3460: 3458: 3455: 3453: 3450: 3449: 3447: 3434: 3433: 3426: 3412: 3409: 3407: 3406:Voltage-gated 3404: 3402: 3399: 3397: 3394: 3393: 3391: 3389: 3385: 3381: 3377: 3372: 3368: 3354: 3351: 3345: 3342: 3340: 3337: 3335: 3332: 3331: 3329: 3325: 3322: 3320: 3317: 3315: 3312: 3311: 3309: 3305: 3302: 3300: 3297: 3295: 3292: 3290: 3287: 3285: 3282: 3280: 3277: 3275: 3272: 3271: 3269: 3265: 3262: 3260: 3257: 3255: 3252: 3250: 3247: 3245: 3242: 3240: 3237: 3235: 3232: 3231: 3229: 3228: 3227: 3224: 3223: 3221: 3219: 3216: 3214: 3209: 3203: 3200: 3196: 3193: 3191: 3188: 3186: 3183: 3182: 3181: 3178: 3174: 3171: 3169: 3166: 3164: 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2728: 2725: 2723: 2720: 2718: 2715: 2713: 2710: 2709: 2708: 2705: 2701: 2698: 2696: 2693: 2691: 2688: 2686: 2683: 2681: 2678: 2676: 2673: 2671: 2668: 2666: 2663: 2661: 2658: 2657: 2656: 2653: 2651: 2648: 2642: 2639: 2637: 2634: 2632: 2629: 2627: 2624: 2623: 2622: 2619: 2615: 2612: 2610: 2607: 2606: 2605: 2602: 2598: 2595: 2594: 2593: 2590: 2589: 2588: 2585: 2584: 2582: 2580: 2577: 2575: 2570: 2566: 2562: 2561:Miscellaneous 2557: 2553: 2539: 2538:Shaker (gene) 2536: 2532: 2529: 2527: 2524: 2522: 2519: 2518: 2517: 2514: 2512: 2511:minK/ISK-like 2509: 2507: 2504: 2500: 2497: 2495: 2492: 2490: 2487: 2485: 2482: 2481: 2480: 2477: 2473: 2470: 2468: 2465: 2463: 2460: 2459: 2458: 2451: 2450: 2445: 2442: 2440: 2437: 2435: 2432: 2431: 2430: 2426: 2423: 2421: 2418: 2416: 2413: 2412: 2411: 2407: 2404: 2402: 2399: 2398: 2397: 2393: 2390: 2388: 2385: 2383: 2380: 2379: 2378: 2374: 2371: 2369: 2366: 2365: 2364: 2360: 2357: 2355: 2352: 2350: 2347: 2345: 2342: 2340: 2337: 2336: 2335: 2328: 2327: 2322: 2319: 2317: 2314: 2312: 2309: 2307: 2304: 2303: 2302: 2298: 2295: 2294: 2293: 2289: 2286: 2284: 2281: 2279: 2276: 2275: 2274: 2270: 2267: 2265: 2262: 2260: 2257: 2255: 2252: 2251: 2250: 2246: 2243: 2241: 2238: 2237: 2236: 2232: 2229: 2227: 2224: 2222: 2219: 2217: 2214: 2212: 2209: 2207: 2204: 2202: 2199: 2197: 2194: 2193: 2192: 2185: 2184: 2182: 2180: 2179:Voltage-gated 2176: 2168: 2165: 2163: 2160: 2158: 2155: 2153: 2150: 2148: 2145: 2143: 2140: 2138: 2135: 2133: 2130: 2128: 2125: 2123: 2120: 2118: 2115: 2113: 2110: 2108: 2105: 2103: 2100: 2098: 2095: 2094: 2093: 2090: 2089: 2087: 2085: 2081: 2073: 2070: 2068: 2065: 2063: 2060: 2058: 2055: 2053: 2050: 2048: 2045: 2044: 2043: 2037: 2033: 2030: 2028: 2025: 2023: 2020: 2018: 2015: 2014: 2013: 2006: 2003: 1999: 1996: 1994: 1991: 1989: 1986: 1984: 1981: 1979: 1976: 1974: 1971: 1970: 1969: 1963: 1961: 1955: 1954: 1952: 1950: 1946: 1938: 1935: 1933: 1930: 1928: 1925: 1923: 1920: 1918: 1915: 1913: 1910: 1908: 1905: 1903: 1900: 1899: 1898: 1892: 1888: 1885: 1884: 1882: 1878: 1875: 1873: 1870: 1868: 1865: 1864: 1863: 1860: 1856: 1853: 1851: 1848: 1846: 1843: 1841: 1838: 1836: 1833: 1832: 1831: 1828: 1827: 1825: 1823: 1819: 1815: 1811: 1808: 1803: 1799: 1783: 1780: 1778: 1775: 1773: 1770: 1768: 1765: 1764: 1763: 1756: 1752: 1749: 1747: 1744: 1742: 1739: 1737: 1734: 1732: 1729: 1727: 1724: 1722: 1719: 1717: 1714: 1712: 1709: 1707: 1704: 1703: 1702: 1695: 1694: 1692: 1690: 1689:Voltage-gated 1686: 1678: 1675: 1673: 1670: 1668: 1665: 1663: 1660: 1659: 1658: 1655: 1654: 1652: 1649: 1645: 1637: 1634: 1632: 1629: 1627: 1624: 1622: 1619: 1618: 1617: 1614: 1613: 1611: 1607: 1603: 1599: 1596: 1591: 1587: 1571: 1568: 1566: 1563: 1562: 1561: 1558: 1554: 1551: 1549: 1546: 1544: 1541: 1539: 1536: 1535: 1534: 1531: 1530: 1525: 1522: 1520: 1517: 1515: 1512: 1510: 1507: 1506: 1505: 1502: 1498: 1495: 1493: 1490: 1488: 1485: 1483: 1480: 1479: 1478: 1475: 1471: 1468: 1466: 1463: 1462: 1461: 1454: 1453: 1448: 1445: 1443: 1440: 1438: 1435: 1434: 1433: 1425: 1422: 1420: 1412: 1409: 1407: 1399: 1396: 1392: 1389: 1388: 1387: 1379: 1376: 1374: 1366: 1363: 1359: 1356: 1354: 1351: 1349: 1346: 1344: 1341: 1340: 1339: 1331: 1328: 1327: 1325: 1323: 1322:Voltage-gated 1319: 1311: 1308: 1306: 1303: 1301: 1298: 1297: 1296: 1293: 1289: 1286: 1284: 1281: 1279: 1276: 1275: 1274: 1271: 1270: 1268: 1264: 1260: 1256: 1253: 1248: 1244: 1239: 1235: 1231: 1224: 1219: 1217: 1212: 1210: 1205: 1204: 1201: 1194: 1190: 1187: 1177:on 2016-08-10 1176: 1172: 1168: 1164: 1154:on 2021-04-17 1153: 1149: 1145: 1141: 1137: 1133: 1129: 1128: 1115: 1111: 1106: 1101: 1097: 1093: 1089: 1085: 1081: 1074: 1066: 1062: 1058: 1054: 1047: 1039: 1035: 1031: 1027: 1023: 1019: 1015: 1011: 1007: 1003: 999: 992: 984: 980: 976: 970: 966: 962: 958: 957: 949: 941: 937: 932: 927: 923: 919: 915: 911: 907: 900: 892: 888: 883: 878: 874: 870: 866: 862: 858: 854: 850: 843: 829: 825: 819: 811: 805: 801: 794: 792: 790: 781: 777: 773: 769: 764: 759: 755: 751: 747: 740: 733: 730: 726: 722: 718: 714: 708: 702: 701: 696: 691: 687: 676: 673: 672: 666: 664: 660: 655: 652: 648: 644: 635: 626: 624: 620: 616: 612: 608: 604: 603:P2X receptors 589: 587: 584: 581: 578: 574: 570: 568: 565: 564: 560: 557: 554: 551: 547: 545: 542: 541: 538: 534: 531: 529: 525: 522: 519: 516: 512: 509: 507: 504: 503: 500: 492: 490: 486: 483: 480: 478: 472: 470: 463: 462: 459: 456: 454: 451: 449: 446: 444: 441: 439: 436: 435: 430: 427: 426: 415: 412:), thalamus ( 411: 407: 403: 401: 398: 397: 392: 383: 382: 377: 368: 367: 362: 355: 352: 350:("Transient") 349: 346: 345: 341: 340:granule cells 338: 335: 328: 325: 324: 319: 312: 309: 306: 303: 302: 299: 298:granule cells 296: 292: 289: 282: 279: 278: 273: 266: 263: 261: 257: 254: 253: 249: 245: 226: 223: 222: 217: 210: 207: 204: 201: 200: 195: 188: 185: 184: 179: 170: 169: 164: 156: 155: 150: 141: 140: 135: 128: 125: 122: 119: 118: 115: 112: 110: 107: 105: 98: 96: 93: 91: 88: 87: 82: 79: 78: 76: 69:Voltage-gated 66: 58: 57: 53: 49: 44: 42: 38: 34: 30: 26: 22: 3452:Ion channels 3429: 3396:Ligand-gated 3387: 3375: 3218:Gap junction 3211: 3100: 2896: 2857: 2835: 2808: 2794: 2770: 2748: 2706: 2654: 2620: 2603: 2591: 2572: 2560: 2515: 2478: 2452: 2329: 2186: 2091: 2038: 2008: 1964: 1893: 1806: 1757: 1696: 1594: 1503: 1476: 1455: 1427: 1414: 1401: 1381: 1368: 1333: 1266:Ligand-gated 1254: 1251: 1234:ion channels 1179:. Retrieved 1175:the original 1170: 1156:. Retrieved 1152:the original 1147: 1135: 1087: 1083: 1073: 1056: 1052: 1046: 1005: 1001: 991: 955: 948: 913: 909: 899: 856: 852: 842: 831:. Retrieved 827: 818: 800:Pharmacology 799: 753: 749: 739: 716: 712: 707: 698: 690: 656: 647:hypertension 640: 629:Pharmacology 619:SOC channels 600: 566: 555:TPCN1, TPCN2 457: 452: 447: 442: 437: 428: 423:Ligand-gated 394: 379: 364: 321: 307:("Residual") 275: 243:, possibly γ 219: 181: 166: 152: 137: 113: 108: 99: 94: 89: 80: 64: 55: 45: 20: 18: 3401:Light-gated 1883:IK channel 25:ion channel 3446:Categories 2604:Bestrophin 1862:SK channel 1830:BK channel 1504:γ-subunits 1477:β-subunits 1460:δ-subunits 1181:2021-06-18 1158:2008-12-17 833:2017-12-11 682:References 410:osteocytes 337:Cerebellar 295:Cerebellar 3432:disorders 3430:see also 3213:Cytoplasm 3123:Aquaporin 2592:Anoctamin 2415:11.1/hERG 1022:0036-8075 983:259784278 873:0031-9333 772:1948-7193 515:T-tubules 406:pacemaker 3226:Connexin 2506:minK/ISK 1114:20091047 1038:22271779 1030:26680202 940:27913208 891:26400989 780:29131938 669:See also 663:epilepsy 623:Cat-Sper 537:myocytes 497:by e.g. 469:receptor 458:Function 453:Location 443:Gated by 414:thalamus 3353:Innexin 3110:solutes 1105:3312315 1065:3540226 1002:Science 931:5420336 882:4600950 732:8791458 657:T-type 641:L-type 396:CACNA1I 381:CACNA1H 366:CACNA1G 323:CACNA1E 277:CACNA1A 221:CACNA1B 193:δ, β, γ 183:CACNA1F 168:CACNA1D 154:CACNA1C 139:CACNA1S 95:Voltage 29:calcium 1650:-gated 1648:Proton 1424:T-type 1411:R-type 1398:Q-type 1378:P-type 1365:N-type 1330:L-type 1195:(MeSH) 1112:  1102:  1063:  1036:  1028:  1020:  981:  971:  938:  928:  889:  879:  871:  806:  778:  770:  617:, and 56:  41:ligand 23:is an 3264:GJA10 3115:Porin 3015:TRPML 2785:HVCN1 2479:KCNIP 2334:α7-12 1238:TC 1A 1034:S2CID 979:S2CID 550:NAADP 499:GPCRs 248:brain 3344:GJD4 3339:GJD3 3334:GJD2 3324:GJC3 3319:GJC2 3314:GJC1 3304:GJB7 3299:GJB6 3294:GJB5 3289:GJB4 3284:GJB3 3279:GJB2 3274:GJB1 3259:GJA9 3254:GJA8 3249:GJA5 3244:GJA4 3239:GJA3 3234:GJA1 3059:TRPV 3042:TRPP 3037:TRPN 2968:TRPM 2921:TRPC 2911:TRPA 2749:CLNS 2707:CLIC 2655:CLCN 2650:CFTR 2597:ANO1 2516:MiRP 2444:12.3 2439:12.2 2434:12.1 2425:11.3 2420:11.2 2406:10.2 2401:10.1 2191:α1-6 2005:GIRK 1419:α2.3 1406:α2.1 1373:α2.2 1110:PMID 1061:PMID 1026:PMID 1018:ISSN 969:ISBN 936:PMID 914:1864 887:PMID 869:ISSN 804:ISBN 776:PMID 768:ISSN 729:PMID 448:Gene 438:Type 90:Type 3108:(+ 2946:4AP 2859:HCN 2392:9.3 2387:9.2 2382:9.1 2373:8.2 2368:8.1 2359:7.5 2354:7.4 2349:7.3 2344:7.2 2339:7.1 2321:6.4 2316:6.3 2311:6.2 2306:6.1 2297:5.1 2288:4.3 2283:4.2 2278:4.1 2269:3.4 2264:3.3 2259:3.2 2254:3.1 2245:2.2 2240:2.1 2231:1.8 2226:1.7 2221:1.6 2216:1.5 2211:1.4 2206:1.3 2201:1.2 2196:1.1 2092:K2P 2072:7.1 2067:6.2 2062:6.1 2057:5.1 2052:4.2 2047:4.1 2032:3.4 2027:3.3 2022:3.2 2017:3.1 1998:2.6 1993:2.4 1988:2.3 1983:2.2 1978:2.1 1973:1.1 1959:ATP 1937:5.1 1932:4.2 1927:4.1 1922:3.1 1917:2.3 1912:2.2 1907:2.1 1902:1.1 1887:IK1 1877:SK3 1872:SK2 1867:SK1 1746:1.9 1741:1.8 1736:1.7 1731:1.6 1726:1.5 1721:1.4 1716:1.3 1711:1.2 1706:1.1 1595:Na: 1447:3.3 1442:3.2 1437:3.1 1391:2.1 1358:1.4 1353:1.3 1348:1.2 1343:1.1 1252:Ca: 1100:PMC 1092:doi 1088:460 1010:doi 1006:350 961:doi 926:PMC 918:doi 877:PMC 861:doi 758:doi 721:doi 697:at 535:in 513:in 391:3.3 376:3.2 361:3.1 318:2.3 272:2.1 239:, β 235:, β 231:δ/β 216:2.2 178:1.4 163:1.3 149:1.2 134:1.1 3448:: 3330:D 3310:C 3270:B 3230:A 3112:): 2865:FC 2759:1B 2754:1A 2742:L1 2700:KB 2695:KA 2574:Cl 2167:18 2162:17 2157:16 2152:15 2147:13 2142:12 2137:10 2041:ir 2011:ir 1967:ir 1896:Ca 1855:β4 1850:β3 1845:β2 1840:β1 1835:α1 1807:K: 1758:Na 1751:7A 1697:Na 1524:γ4 1519:γ3 1514:γ2 1509:γ1 1497:β4 1492:β3 1487:β2 1482:β1 1428:Ca 1415:Ca 1402:Ca 1382:Ca 1369:Ca 1334:Ca 1232:: 1169:. 1146:. 1134:. 1108:. 1098:. 1086:. 1082:. 1055:. 1032:. 1024:. 1016:. 1004:. 1000:. 977:. 967:. 934:. 924:. 912:. 908:. 885:. 875:. 867:. 857:95 855:. 851:. 826:. 788:^ 774:. 766:. 752:. 748:. 727:. 715:. 613:, 609:, 605:, 577:SR 573:ER 528:SR 524:ER 489:SR 485:ER 474:IP 465:IP 416:) 387:Ca 372:Ca 357:Ca 314:Ca 268:Ca 212:Ca 174:Ca 159:Ca 157:) 145:Ca 130:Ca 19:A 3215:: 3195:3 3190:2 3185:1 3173:9 3168:8 3163:7 3158:6 3153:5 3148:4 3143:3 3138:2 3133:1 3128:0 3106:O 3104:2 3102:H 3089:6 3084:5 3079:4 3074:3 3069:2 3064:1 3052:2 3047:1 3030:3 3025:2 3020:1 3008:8 3003:7 2998:6 2993:5 2988:4 2983:3 2978:2 2973:1 2961:7 2956:6 2951:5 2941:4 2936:3 2931:2 2926:1 2917:) 2915:1 2913:( 2900:: 2898:M 2885:4 2880:3 2875:2 2870:1 2851:3 2846:2 2841:1 2836:β 2829:4 2824:3 2819:2 2814:1 2809:α 2798:: 2796:M 2774:: 2772:H 2737:6 2732:5 2727:4 2722:3 2717:2 2712:1 2690:7 2685:6 2680:5 2675:4 2670:3 2665:2 2660:1 2641:4 2636:3 2631:2 2626:1 2614:2 2609:1 2576:: 2531:3 2526:2 2521:1 2499:4 2494:3 2489:2 2484:1 2472:3 2467:2 2462:1 2457:β 2455:v 2453:K 2332:v 2330:K 2189:v 2187:K 2132:9 2127:7 2122:6 2117:5 2112:4 2107:3 2102:2 2097:1 2039:K 2009:K 2007:/ 1965:K 1957:K 1894:K 1782:4 1777:3 1772:2 1767:1 1762:β 1760:v 1701:α 1699:v 1677:4 1672:3 1667:2 1662:1 1636:δ 1631:γ 1626:β 1621:α 1570:2 1565:1 1553:4 1548:3 1543:2 1538:1 1470:2 1465:1 1458:2 1456:α 1432:α 1430:v 1426:/ 1417:v 1413:/ 1404:v 1400:/ 1386:α 1384:v 1380:/ 1371:v 1367:/ 1338:α 1336:v 1332:/ 1310:3 1305:2 1300:1 1288:3 1283:2 1278:1 1240:) 1236:( 1222:e 1215:t 1208:v 1184:. 1161:. 1138:. 1116:. 1094:: 1067:. 1057:2 1040:. 1012:: 985:. 963:: 942:. 920:: 893:. 863:: 836:. 812:. 782:. 760:: 754:8 734:. 723:: 717:8 575:/ 552:) 526:/ 495:3 487:/ 476:3 467:3 399:) 393:( 389:v 384:) 378:( 374:v 369:) 363:( 359:v 331:2 329:α 326:) 320:( 316:v 285:2 283:α 280:) 274:( 270:v 241:4 237:3 233:1 229:2 227:α 224:) 218:( 214:v 191:2 189:α 186:) 180:( 176:v 171:) 165:( 161:v 151:( 147:v 142:) 136:( 132:v 102:1 100:α

Index

ion channel
calcium
voltage-gated calcium channel
membrane potential
ligand
action potentials
second messengers
voltage-gated calcium channel
L-type calcium channel
Cav1.1
CACNA1S
Cav1.2
CACNA1C
Cav1.3
CACNA1D
Cav1.4
CACNA1F
N-type calcium channel
Cav2.2
CACNA1B
brain
P-type calcium channel
Q-type calcium channel
Cav2.1
CACNA1A
Purkinje neurons
Cerebellar
granule cells
R-type calcium channel
Cav2.3

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