40:
622:
599:
1602:
1624:
31:
4012:
1989:
1477:
1179:
1974:
694:
874:
treatment of adults with HER2-overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma who have not received prior treatment for metastatic disease as a component of a combination regimen;
1494:
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1142:. Those with partial or complete DPD deficiency have a significantly increased risk of severe or even fatal drug toxicities when treated with fluoropyrimidines; examples of toxicities include
1966:
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245:
2118:
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may enhance the therapeutic effects of capecitabine by means of synergising with its metabolite, 5-FU. It may also induce more severe diarrhoea by means of this synergy.
2014:
868:
treatment of people with advanced or metastatic breast cancer in combination with docetaxel after disease progression on prior anthracycline-containing chemotherapy;
736:
InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
3878:
871:
treatment of adults with unresectable or metastatic gastric, esophageal, or gastroesophageal junction cancer as a component of a combination chemotherapy regimen;
4077:
200:
865:
treatment of people with advanced or metastatic breast cancer as a single agent if an anthracycline- or taxane-containing chemotherapy is not indicated;
2181:
Amstutz U, Froehlich TK, Largiadèr CR (September 2011). "Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity".
2290:
2077:
2224:
1514:
1513:
1484:
1216:
1215:
1186:
1512:
1214:
862:
treatment of people with unresectable or metastatic colorectal cancer as a single agent or as a component of a combination chemotherapy regimen;
2036:
1483:
1185:
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2253:
1528:
1230:
116:
3938:
2990:
708:
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1837:"Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing"
1503:
1205:
1018:
1515:
1217:
1692:
1527:
1229:
1517:
1219:
2107:
1548:
856:
adjuvant treatment of people with Stage III colon cancer as a single agent or as a component of a combination chemotherapy regimen;
1967:"FDA approves updated drug labeling including new indications and dosing regimens for capecitabine tablets under Project Renewal"
1526:
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1228:
1225:
1500:
1492:
1202:
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1806:
1520:
1508:
1222:
1210:
1110:(DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes capecitabine,
4042:
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2006:
837:
1490:
1489:
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adjuvant treatment of adults with pancreatic adenocarcinoma as a component of a combination chemotherapy regimen.
376:
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perioperative treatment of adults with locally advanced rectal cancer as a component of chemoradiotherapy;
3475:
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1713:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
578:
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Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, et al. (December 2013).
1741:
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Capecitabine was patented in 1992 and approved for medical use in 1998. It is on the
783:
269:
257:
140:
2217:"Xeloda (capecitabine) dosing, indications, interactions, adverse effects, and more"
1802:
126:
3918:
3675:
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3024:
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2190:
1931:
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997:
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801:, weakness, and rashes. Other severe side effects include blood clotting problems,
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213:
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1015:
History of hypersensitivity to fluorouracil, capecitabine or any of its excipients
427:
4016:
3357:
3319:
3110:
2532:
2447:
332:
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may result in harm to the fetus. Capecitabine, inside the body, is converted to
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2347:
2317:
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1139:
1135:
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Click on genes, proteins and metabolites below to link to respective articles.
821:(5-FU) through which it acts. It belongs to the class of medications known as
4026:
3851:
3811:
3181:
3054:
2935:
2878:
2636:
2585:
1993:
1147:
775:
610:
282:
22:
337:
liver, to 5'-DFCR, 5'-DFUR (inactive); neoplastic tissue, 5'-DFUR to active
3898:
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2140:
1928:
World Health
Organization model list of essential medicines: 21st list 2019
1870:
1127:
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2337:
2157:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust.
1601:
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1936:
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478:
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2194:
1126:) can lead to reduced or absent DPD activity, and individuals who are
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2007:"XELODA (capecitabine) tablet, film coated [Genentech, Inc.]"
1770:(69 ed.). British Medical Association. 2015. pp. 585, 588.
1685:
1088:
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1992:
This article incorporates text from this source, which is in the
1115:
985:
830:
2390:
2078:"Capecitabine 150mg – Summary of Product Characteristics (SPC)"
1589:(ThMP), the active form of thymidine which is required for the
1078:
931:
558:
30:
90:
2246:. In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.).
684:
538:
583:
1567:
The interactive pathway map can be edited at WikiPathways:
518:
84:
78:
1691:
Others include
Xitabin, Capcibin, Kapetral and Pecaset by
2180:
1922:
1720:
1091:, as it increases the plasma concentrations of phenytoin.
69:
63:
1940:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1581:
Capecitabine is metabolised to 5-FU which in turn is a
838:
797:
Common side effects include abdominal pain, vomiting,
4000:
2037:"Capecitabine Teva : EPAR – Product Information"
1805:. The American Society of Health-System Pharmacists.
93:
75:
60:
1834:
1045:
Severe hepatic impairment or severe renal impairment
87:
81:
66:
1705:
786:. For breast cancer it is often used together with
446:
72:
1134:for these variations may have partial or complete
1138:; an estimated 0.2% of individuals have complete
4024:
426:
2176:
2174:
2117:. Roche Products Pty Limited. 5 December 2013.
1883:
1479:
1181:
401:
1830:
1828:
1826:
1824:
1684:One of the brand names is Xeloda, marketed by
4078:World Health Organization essential medicines
2284:
2254:National Center for Biotechnology Information
1585:inhibitor, hence inhibiting the synthesis of
1085:and other coumarin-derivatives anticoagulants
1052:or its chemically related analogues, such as
716:FC=1\C(=N/C(=O)N(C=1)2O((O)2O)C)\NC(=O)OCCCCC
2171:
1961:
1959:
1957:
1955:
1953:
1951:
1949:
1947:
1561:
1064:Drugs it is known to interact with include:
2108:"NAME OF THE MEDICINE XELODA® Capecitabine"
2084:. Zentiva. 23 December 2013. Archived from
1821:
1652:. Unsourced material may be challenged and
2291:
2277:
1797:
1795:
1793:
1791:
1789:
1787:
620:
597:
486:
1944:
1935:
1860:
1672:Learn how and when to remove this message
506:
2244:"Capecitabine Therapy and DPYD Genotype"
1768:British national formulary : BNF 69
1784:
593:
466:
139:
4025:
2121:from the original on 11 September 2017
2072:
2070:
2068:
1916:
1890:. John Wiley & Sons. p. 511.
1877:
1841:Clinical Pharmacology and Therapeutics
1608:
1157:
611:
291:
263:
2272:
2227:from the original on 2 February 2014.
2152:
2133:
1930:. Geneva: World Health Organization.
1022:
566:
546:
276:
125:
4048:Drugs developed by Hoffmann-La Roche
2241:
2053:from the original on 4 February 2014
2046:. Teva Pharma B.V. 10 January 2014.
2017:from the original on 1 February 2014
1977:from the original on 27 January 2023
1904:from the original on 12 January 2023
1760:
1650:adding citations to reliable sources
1617:
1059:
1006:
212:
2560:ribonucleotide reductase inhibitors
2209:
2146:
2100:
2065:
2029:
1538:|alt=Fluorouracil (5-FU) Activity
1101:
526:
417:
13:
2726:Ribonucleotide reductase inhibitor
2682:Ribonucleotide reductase inhibitor
2235:
2139:Reddening, swelling, numbness and
1809:from the original on 15 April 2016
1600:
1475:
1468:
1463:
1458:
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1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1177:
881:
14:
4089:
2485:Dihydrofolate reductase inhibitor
2013:. Genentech, Inc. December 2013.
1999:
1971:U.S. Food and Drug Administration
1596:
1570:"FluoropyrimidineActivity_WP1601"
239:
159:
111:Xeloda, Xitabin, Kapetral, others
4010:
1987:
1622:
654:
651:
645:
56:
38:
29:
2082:electronic Medicines Compendium
1884:Fischer J, Ganellin CR (2006).
1108:dihydropyrimidine dehydrogenase
978:
890:Very common (>10% frequency)
843:
741:Key:GAGWJHPBXLXJQN-UORFTKCHSA-N
2622:Thymidylate synthase inhibitor
2512:Thymidylate synthase inhibitor
1734:
1613:
1551:Fluorouracil (5-FU) Activity
886:Adverse effects by frequency:
660:
639:
252:
1:
2542:Adenosine deaminase inhibitor
2383:Block microtubule disassembly
2155:Australian Medicines Handbook
1887:Analogue-based Drug Discovery
1698:
363:kidney (95.5%), faecal (2.6%)
4043:Drugs developed by Genentech
766:, sold under the brand name
7:
1071:or its analogues, such as,
1011:Contraindications include:
10:
4094:
2264:. Bookshelf ID: NBK385155.
2249:Medical Genetics Summaries
2223:. WebMD. 25 January 2014.
973:Notes on adverse effects:
629:Chemical and physical data
3961:
3842:Omacetaxine mepesuccinate
3722:Ciltacabtagene autoleucel
3712:Brexucabtagene autoleucel
3658:
3609:
3389:
3382:
3318:
3272:
3205:
3162:
2999:
2984:
2864:
2834:
2759:
2744:
2715:
2611:
2531:
2474:
2457:
2446:
2382:
2335:
2316:
2044:European Medicines Agency
1924:World Health Organization
1746:European Medicines Agency
805:, heart problems such as
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724:
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682:
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633:
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229:
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199:
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147:
133:
115:
105:
51:
46:
37:
28:
3894:Talimogene laherparepvec
3827:Nadofaragene firadenovec
3797:Lisocabtagene maraleucel
2746:Topoisomerase inhibitors
2665:DNA polymerase inhibitor
3697:Axicabtagene ciloleucel
2301:chemotherapeutic agents
1587:thymidine monophosphate
1081:substrates, including,
1028:Pregnancy and lactation
4063:Pyrimidine antagonists
3879:Sitimagene ceradenovec
3777:Idecabtagene vicleucel
3342:Methyl aminolevulinate
2115:TGA eBusiness Services
1605:
1532:
1234:
825:, which also includes
3353:Porphyrin derivatives
3049:Melphalan flufenamide
2696:Hypomethylating agent
2305:antineoplastic agents
2153:Rossi S, ed. (2013).
1853:10.1038/clpt.2013.172
1604:
1531:
1233:
1122:within the DPD gene (
811:low blood cell counts
772:anticancer medication
3682:Asparagine depleters
3611:Receptor antagonists
3525:+abiraterone acetate
1973:. 15 December 2022.
1646:improve this section
1583:thymidylate synthase
194:Antineoplastic agent
3732:Denileukin diftitox
3632:Retinoid X receptor
3332:Aminolevulinic acid
3154:Triethylenemelamine
2986:Crosslinking of DNA
2717:Deoxyribonucleotide
2656:+gimeracil/oteracil
1609:Society and culture
1158:Mechanism of action
961:Shortness of breath
770:among others, is a
272:(Prescription only)
248:(Prescription only)
25:
3988:Never to phase III
2790:Etirinotecan pegol
2221:Medscape Reference
2143:on palms and soles
2088:on 1 February 2014
1606:
1593:synthesis of DNA.
1533:
1235:
1152:hand-foot syndrome
1120:Genetic variations
927:Hand-foot syndrome
803:allergic reactions
21:
4038:Fluoropyrimidines
3998:
3997:
3957:
3956:
3914:Tigilanol tiglate
3391:Enzyme inhibitors
3314:
3313:
3310:
3309:
3010:Nitrogen mustards
2980:
2979:
2740:
2739:
2442:
2441:
2195:10.2217/pgs.11.72
2164:978-0-9805790-9-3
1748:. 2 February 2001
1682:
1681:
1674:
1060:Drug interactions
1007:Contraindications
823:fluoropyrimidines
784:colorectal cancer
761:
760:
695:Interactive image
579:CompTox Dashboard
295:
280:
267:
255:
243:
163:
16:Chemical compound
4085:
4015:
4014:
4013:
4006:
3919:Tisagenlecleucel
3676:Arsenic trioxide
3387:
3386:
3320:Photosensitizers
3111:Alkyl sulfonates
3025:Cyclophosphamide
2997:
2996:
2936:Anthracenediones
2757:
2756:
2731:Hydroxycarbamide
2472:
2471:
2455:
2454:
2333:
2332:
2293:
2286:
2279:
2270:
2269:
2265:
2229:
2228:
2213:
2207:
2206:
2189:(9): 1321–1336.
2183:Pharmacogenomics
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1717:nctr-crs.fda.gov
1709:
1677:
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1471:
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1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1251:
1246:
1241:
1144:myelosuppression
1102:Pharmacogenetics
1095:Calcium folinate
1041:thrombocytopenia
1023:Pharmacogenetics
1000:
998:thrombocytopenia
982:
968:Myelosuppression
848:Capecitabine is
757:
756:
697:
677:
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384:Pentyl carbamate
349:
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24:
20:
4093:
4092:
4088:
4087:
4086:
4084:
4083:
4082:
4073:Specialty drugs
4053:Organofluorides
4023:
4022:
4021:
4011:
4009:
4001:
3999:
3994:
3993:
3978:Clinical trials
3953:
3659:Other/ungrouped
3654:
3605:
3378:
3358:Porfimer sodium
3306:
3268:
3201:
3158:
2988:
2976:
2860:
2830:
2748:
2736:
2711:
2607:
2527:
2463:
2461:antimetabolites
2459:
2458:DNA precursors/
2450:
2448:DNA replication
2438:
2378:
2348:Vinca alkaloids
2324:
2312:
2297:
2242:Dean L (2016).
2238:
2236:Further reading
2233:
2232:
2215:
2214:
2210:
2179:
2172:
2165:
2151:
2147:
2138:
2134:
2124:
2122:
2110:
2106:
2105:
2101:
2091:
2089:
2076:
2075:
2066:
2056:
2054:
2050:
2039:
2035:
2034:
2030:
2020:
2018:
2005:
2004:
2000:
1988:
1980:
1978:
1965:
1964:
1945:
1921:
1917:
1907:
1905:
1898:
1882:
1878:
1833:
1822:
1812:
1810:
1801:
1800:
1785:
1778:
1766:
1765:
1761:
1751:
1749:
1740:
1739:
1735:
1725:
1723:
1711:
1710:
1706:
1701:
1678:
1667:
1661:
1658:
1643:
1627:
1616:
1611:
1599:
1579:
1578:
1577:
1568:
1566:
1562:
1557:
1556:
1555:
1550:
1545:
1544:
1543:
1537:
1536:
1535:
1534:
1530:
1473:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1389:
1387:
1384:
1382:
1379:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1236:
1232:
1160:
1104:
1062:
1048:Treatment with
1009:
1004:
1003:
983:
979:
971:
884:
882:Adverse effects
846:
752:
750:
745:
742:
737:
732:
731:
720:
717:
712:
711:
700:
675:
665:
659:
650:
644:
605:
581:
573:
553:
533:
513:
493:
473:
453:
433:
416:
408:
388:
385:
380:
379:
347:
323:Protein binding
313:Bioavailability
305:Pharmacokinetic
299:
283:
220:
176:
169:
150:
59:
55:
17:
12:
11:
5:
4091:
4081:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4020:
4019:
3996:
3995:
3992:
3991:
3990:
3989:
3986:
3975:
3969:
3963:
3962:
3959:
3958:
3955:
3954:
3952:
3951:
3946:
3941:
3936:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3865:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3678:
3673:
3668:
3662:
3660:
3656:
3655:
3653:
3652:
3640:
3628:
3615:
3613:
3607:
3606:
3604:
3603:
3597:
3592:
3587:
3582:
3570:
3564:
3559:
3554:
3549:
3538:
3532:
3527:
3519:
3512:PARP inhibitor
3508:
3496:
3484:
3472:
3471:
3470:
3465:
3460:
3455:
3443:
3437:
3432:
3427:
3422:
3408:
3395:
3393:
3384:
3380:
3379:
3377:
3376:
3370:
3365:
3360:
3349:
3344:
3339:
3334:
3328:
3326:
3316:
3315:
3312:
3311:
3308:
3307:
3305:
3304:
3298:
3293:
3288:
3278:
3276:
3270:
3269:
3267:
3266:
3260:
3255:
3244:
3239:
3234:
3229:
3217:
3211:
3209:
3203:
3202:
3200:
3199:
3194:
3189:
3184:
3179:
3174:
3168:
3166:
3164:Platinum-based
3160:
3159:
3157:
3156:
3151:
3146:
3141:
3129:
3128:
3122:
3106:
3105:
3100:
3095:
3090:
3080:
3075:
3063:
3062:
3057:
3052:
3042:
3037:
3031:
3022:
3017:
3005:
3003:
2994:
2982:
2981:
2978:
2977:
2975:
2974:
2969:
2964:
2959:
2954:
2948:
2943:
2932:
2926:
2921:
2916:
2911:
2906:
2901:
2891:
2886:
2879:Anthracyclines
2874:
2872:
2862:
2861:
2859:
2858:
2852:
2840:
2838:
2832:
2831:
2829:
2828:
2822:
2817:
2812:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2765:
2763:
2754:
2742:
2741:
2738:
2737:
2735:
2734:
2721:
2719:
2713:
2712:
2710:
2709:
2703:
2691:
2690:
2677:
2676:
2660:
2659:
2649:
2644:
2639:
2634:
2629:
2617:
2615:
2609:
2608:
2606:
2605:
2599:
2597:Mercaptopurine
2588:
2583:
2578:
2572:
2567:
2551:
2550:
2537:
2535:
2529:
2528:
2526:
2525:
2519:
2508:
2502:
2497:
2492:
2480:
2478:
2469:
2452:
2444:
2443:
2440:
2439:
2437:
2436:
2424:
2418:
2413:
2408:
2403:
2398:
2386:
2384:
2380:
2379:
2377:
2376:
2370:
2365:
2360:
2355:
2343:
2341:
2330:
2314:
2313:
2299:Intracellular
2296:
2295:
2288:
2281:
2273:
2267:
2266:
2237:
2234:
2231:
2230:
2208:
2170:
2163:
2145:
2132:
2099:
2064:
2028:
1998:
1943:
1915:
1896:
1876:
1847:(6): 640–645.
1820:
1803:"Capecitabine"
1783:
1776:
1759:
1733:
1703:
1702:
1700:
1697:
1680:
1679:
1630:
1628:
1621:
1615:
1612:
1610:
1607:
1598:
1597:Drug synthesis
1595:
1576:
1575:
1559:
1558:
1547:
1546:
1474:
1237:
1176:
1175:
1174:
1173:
1171:
1170:
1169:
1168:
1167:
1166:
1159:
1156:
1140:DPD deficiency
1136:DPD deficiency
1112:5-fluorouracil
1103:
1100:
1099:
1098:
1092:
1086:
1076:
1061:
1058:
1057:
1056:
1046:
1043:
1029:
1026:
1019:DPD deficiency
1016:
1008:
1005:
1002:
1001:
976:
975:
970:
969:
966:
965:Eye irritation
963:
958:
953:
948:
943:
940:
937:
934:
929:
924:
919:
916:
915:Abdominal pain
913:
908:
905:
902:
899:
895:
894:
893:
891:
883:
880:
879:
878:
875:
872:
869:
866:
863:
860:
857:
845:
842:
819:5-fluorouracil
807:cardiomyopathy
790:. It is taken
780:gastric cancer
774:used to treat
759:
758:
747:
746:
744:
743:
740:
738:
735:
727:
726:
725:
722:
721:
719:
718:
715:
707:
706:
705:
702:
701:
699:
698:
690:
688:
680:
679:
673:
667:
666:
663:
657:
648:
642:
637:
631:
630:
626:
625:
615:
607:
606:
604:
603:
590:
588:
575:
574:
572:
571:
563:
561:
555:
554:
552:
551:
543:
541:
535:
534:
532:
531:
523:
521:
515:
514:
512:
511:
503:
501:
495:
494:
492:
491:
483:
481:
475:
474:
472:
471:
463:
461:
455:
454:
452:
451:
443:
441:
435:
434:
432:
431:
423:
421:
410:
409:
407:
406:
398:
396:
390:
389:
387:
386:
383:
375:
374:
373:
370:
369:
365:
364:
361:
355:
354:
351:
342:
341:
335:
329:
328:
325:
319:
318:
315:
309:
308:
301:
300:
298:
297:
288:
273:
260:
249:
235:
233:
227:
226:
222:
221:
219:
218:
205:
203:
197:
196:
191:
185:
184:
179:
177:administration
171:
170:
168:
167:
165:
155:
153:
145:
144:
137:
131:
130:
123:
113:
112:
109:
103:
102:
53:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
4090:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4030:
4028:
4018:
4008:
4007:
4004:
3987:
3985:
3982:
3981:
3979:
3976:
3973:
3970:
3968:
3965:
3964:
3960:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3869:
3866:
3864:
3860:
3859:
3855:
3853:
3852:Tabelecleucel
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3812:Lurbinectedin
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3692:
3688:
3684:
3683:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3663:
3661:
3657:
3650:
3646:
3645:
3641:
3638:
3634:
3633:
3629:
3626:
3622:
3621:
3617:
3616:
3614:
3612:
3608:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3577:
3575:
3571:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3544:
3543:
3539:
3536:
3533:
3531:
3528:
3526:
3523:
3520:
3518:
3514:
3513:
3509:
3506:
3502:
3501:
3497:
3494:
3490:
3489:
3485:
3482:
3478:
3477:
3473:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3450:
3449:
3448:
3444:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3417:
3416:
3413:
3409:
3406:
3402:
3401:
3397:
3396:
3394:
3392:
3388:
3385:
3381:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3355:
3354:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3329:
3327:
3325:
3321:
3317:
3302:
3299:
3297:
3294:
3292:
3289:
3287:
3283:
3280:
3279:
3277:
3275:
3274:Intercalation
3271:
3264:
3261:
3259:
3256:
3254:
3250:
3249:
3245:
3243:
3240:
3238:
3235:
3233:
3230:
3227:
3223:
3222:
3218:
3216:
3213:
3212:
3210:
3208:
3204:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3182:Dicycloplatin
3180:
3178:
3175:
3173:
3170:
3169:
3167:
3165:
3161:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3131:
3130:
3126:
3123:
3121:
3117:
3114:
3112:
3108:
3107:
3104:
3101:
3099:
3096:
3094:
3091:
3088:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3065:
3064:
3061:
3058:
3056:
3055:Prednimustine
3053:
3050:
3046:
3043:
3041:
3038:
3035:
3032:
3030:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3007:
3006:
3004:
3002:
2998:
2995:
2992:
2987:
2983:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2952:
2949:
2947:
2944:
2942:
2938:
2937:
2933:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2899:
2895:
2892:
2890:
2887:
2885:
2881:
2880:
2876:
2875:
2873:
2871:
2870:Intercalation
2867:
2863:
2856:
2853:
2851:
2847:
2846:
2842:
2841:
2839:
2837:
2833:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2772:
2771:
2767:
2766:
2764:
2762:
2758:
2755:
2752:
2747:
2743:
2732:
2728:
2727:
2723:
2722:
2720:
2718:
2714:
2707:
2704:
2702:
2698:
2697:
2693:
2692:
2688:
2684:
2683:
2679:
2678:
2674:
2673:+daunorubicin
2671:
2667:
2666:
2662:
2661:
2657:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2637:Doxifluridine
2635:
2633:
2630:
2628:
2624:
2623:
2619:
2618:
2616:
2614:
2610:
2603:
2600:
2598:
2594:
2593:
2589:
2587:
2586:Rabacfosadine
2584:
2582:
2579:
2576:
2573:
2571:
2568:
2566:
2562:
2561:
2557:
2553:
2552:
2548:
2544:
2543:
2539:
2538:
2536:
2534:
2530:
2523:
2520:
2518:
2514:
2513:
2509:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2487:
2486:
2482:
2481:
2479:
2477:
2473:
2470:
2467:
2462:
2456:
2453:
2449:
2445:
2434:
2430:
2429:
2425:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2393:
2392:
2388:
2387:
2385:
2381:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2350:
2349:
2345:
2344:
2342:
2339:
2334:
2331:
2328:
2323:
2319:
2315:
2310:
2306:
2302:
2294:
2289:
2287:
2282:
2280:
2275:
2274:
2271:
2263:
2259:
2255:
2251:
2250:
2245:
2240:
2239:
2226:
2222:
2218:
2212:
2204:
2200:
2196:
2192:
2188:
2184:
2177:
2175:
2166:
2160:
2156:
2149:
2142:
2136:
2120:
2116:
2109:
2103:
2087:
2083:
2079:
2073:
2071:
2069:
2049:
2045:
2038:
2032:
2016:
2012:
2008:
2002:
1995:
1994:public domain
1976:
1972:
1968:
1962:
1960:
1958:
1956:
1954:
1952:
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1938:
1933:
1929:
1925:
1919:
1903:
1899:
1897:9783527607495
1893:
1889:
1888:
1880:
1872:
1868:
1863:
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1779:
1777:9780857111562
1773:
1769:
1763:
1747:
1743:
1742:"Xeloda EPAR"
1737:
1722:
1718:
1714:
1708:
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1696:
1694:
1689:
1687:
1676:
1673:
1665:
1655:
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1647:
1641:
1640:
1636:
1631:This section
1629:
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1620:
1619:
1603:
1594:
1592:
1588:
1584:
1571:
1564:
1560:
1554:
1549:
1541:
1478:
1180:
1165:
1164:
1155:
1153:
1149:
1148:neurotoxicity
1145:
1141:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1109:
1096:
1093:
1090:
1087:
1084:
1080:
1077:
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1066:
1065:
1055:
1051:
1047:
1044:
1042:
1038:
1034:
1030:
1027:
1024:
1020:
1017:
1014:
1013:
1012:
999:
995:
991:
987:
981:
977:
974:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
941:
938:
935:
933:
930:
928:
925:
923:
920:
917:
914:
912:
909:
906:
903:
900:
898:Appetite loss
897:
896:
892:
889:
888:
887:
876:
873:
870:
867:
864:
861:
858:
855:
854:
853:
851:
841:
839:
834:
832:
828:
824:
820:
816:
813:. Use during
812:
808:
804:
800:
795:
793:
789:
785:
781:
777:
776:breast cancer
773:
769:
765:
755:
748:
739:
734:
733:
730:
723:
714:
713:
710:
703:
696:
692:
691:
689:
686:
681:
674:
672:
668:
638:
636:
632:
627:
623:
619:
616:
614:
612:ECHA InfoCard
608:
600:
596:
595:DTXSID3046451
592:
591:
589:
580:
576:
569:
565:
564:
562:
560:
556:
549:
545:
544:
542:
540:
536:
529:
525:
524:
522:
520:
516:
509:
505:
504:
502:
500:
496:
489:
485:
484:
482:
480:
476:
469:
465:
464:
462:
460:
456:
449:
445:
444:
442:
440:
436:
429:
425:
424:
422:
415:
411:
404:
400:
399:
397:
395:
391:
382:
381:
378:
371:
366:
362:
360:
356:
353:38–45 minutes
352:
350:
343:
340:
336:
334:
330:
326:
324:
320:
316:
314:
310:
306:
302:
296: Rx-only
289:
286:
274:
271:
261:
259:
250:
247:
237:
236:
234:
232:
228:
223:
215:
210:
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198:
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186:
183:
180:
178:
172:
166:
157:
156:
154:
152:
146:
142:
138:
136:
132:
128:
124:
122:
118:
114:
110:
108:
104:
98:
54:
52:Pronunciation
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
3899:Tazemetostat
3863:Alitretinoin
3856:
3767:Estramustine
3747:Elsamitrucin
3737:Eflornithine
3691:Pegaspargase
3687:Asparaginase
3680:
3649:Testolactone
3642:
3630:
3618:
3572:
3557:Panobinostat
3540:
3510:
3498:
3486:
3474:
3445:
3410:
3398:
3351:
3347:Padeliporfin
3286:Dactinomycin
3282:Streptomyces
3263:Temozolomide
3258:Mitozolomide
3246:
3237:Mitobronitol
3226:Procarbazine
3219:
3207:Nonclassical
3132:
3109:
3103:Streptozocin
3068:Nitrosoureas
3066:
3040:Chlorambucil
3034:Trofosfamide
3020:Chlormethine
3015:Bendamustine
3008:
2946:Mitoxantrone
2941:Losoxantrone
2934:
2894:Daunorubicin
2877:
2843:
2780:Camptothecin
2768:
2724:
2694:
2680:
2663:
2647:Fluorouracil
2627:Capecitabine
2626:
2620:
2590:
2554:
2540:
2510:
2505:Pralatrexate
2495:Methotrexate
2483:
2426:
2389:
2346:
2248:
2220:
2211:
2186:
2182:
2154:
2148:
2141:desquamation
2135:
2123:. Retrieved
2114:
2102:
2090:. Retrieved
2086:the original
2081:
2055:. Retrieved
2043:
2031:
2019:. Retrieved
2010:
2001:
1979:. Retrieved
1970:
1937:10665/325771
1927:
1918:
1906:. Retrieved
1886:
1879:
1844:
1840:
1811:. Retrieved
1767:
1762:
1750:. Retrieved
1745:
1736:
1724:. Retrieved
1716:
1707:
1690:
1683:
1668:
1659:
1644:Please help
1632:
1590:
1580:
1563:
1162:
1161:
1128:heterozygous
1123:
1105:
1063:
1010:
980:
972:
885:
847:
844:Medical uses
835:
796:
767:
764:Capecitabine
763:
762:
751:
346:Elimination
339:fluorouracil
231:Legal status
225:Legal status
23:Capecitabine
18:
4068:Pyrimidones
3974:from market
3944:Vorasidenib
3924:Trabectedin
3909:Tiazofurine
3904:Tebentafusp
3889:Tagraxofusp
3847:Plitidepsin
3817:Mitoguazone
3757:Epacadostat
3727:Demecolcine
3671:Aflibercept
3644:Sex steroid
3517:Fuzuloparib
3458:Carfilzomib
3430:Palbociclib
3420:Abemaciclib
3373:Verteporfin
3337:Efaproxiral
3253:Dacarbazine
3215:Altretamine
3197:Satraplatin
3192:Oxaliplatin
3172:Carboplatin
3149:Triaziquone
3120:Mannosulfan
3098:Ranimustine
3078:Fotemustine
2919:Pirarubicin
2904:Doxorubicin
2898:+cytarabine
2884:Aclarubicin
2845:Podophyllum
2770:Camptotheca
2701:Azacitidine
2687:Gemcitabine
2642:Floxuridine
2575:Fludarabine
2570:Clofarabine
2556:Halogenated
2547:Pentostatin
2522:Raltitrexed
2490:Aminopterin
2433:Ixabepilone
2428:Epothilones
2396:Cabazitaxel
2373:Vinorelbine
2358:Vincristine
2353:Vinblastine
2338:microtubule
1662:August 2020
1614:Brand names
1037:neutropenia
994:neutropenia
990:lymphopenia
956:Indigestion
678: g·mol
618:100.112.980
548:CHEBI:31348
403:154361-50-9
368:Identifiers
135:MedlinePlus
107:Trade names
4033:Carbamates
4027:Categories
3939:Verdinexor
3934:Venetoclax
3837:Oblimersen
3832:Navitoclax
3807:Lucanthone
3802:Lonidamine
3792:Lifileucel
3787:Ivosidenib
3782:Imetelstat
3752:Enasidenib
3742:Elesclomol
3707:Bexarotene
3702:Belzutifan
3637:Bexarotene
3625:Atrasentan
3600:Umbralisib
3595:Idelalisib
3585:Copanlisib
3567:Vorinostat
3562:Romidepsin
3552:Entinostat
3547:Belinostat
3505:Masoprocol
3493:Tiazofurin
3481:Anagrelide
3453:Bortezomib
3440:Seliciclib
3435:Ribociclib
3415:inhibitors
3405:Tipifarnib
3368:Temoporfin
3363:Talaporfin
3301:Plicamycin
3296:Mitomycins
3242:Pipobroman
3221:Hydrazines
3187:Nedaplatin
3139:Carboquone
3134:Aziridines
3125:Treosulfan
3073:Carmustine
3060:Uramustine
3029:Ifosfamide
3001:Alkylating
2962:Bisantrene
2951:Pixantrone
2924:Valrubicin
2914:Idarubicin
2909:Epirubicin
2855:Teniposide
2810:Lurtotecan
2805:Irinotecan
2706:Decitabine
2670:Cytarabine
2613:Pyrimidine
2602:Tioguanine
2592:Thiopurine
2581:Nelarabine
2565:Cladribine
2517:Pemetrexed
2500:Pemetrexed
2476:Folic acid
2416:Paclitaxel
2368:Vinflunine
2125:25 January
2092:25 January
2057:25 January
2021:25 January
1981:26 January
1813:8 December
1726:22 October
1699:References
1132:homozygous
1069:Sorivudine
1050:sorivudine
1033:leucopenia
984:Includes:
951:Dermatitis
911:Stomatitis
683:3D model (
671:Molar mass
568:ChEMBL1773
508:6804DJ8Z9U
479:ChemSpider
439:IUPHAR/BPS
394:CAS Number
377:IUPAC name
333:Metabolism
189:Drug class
3984:Phase III
3972:Withdrawn
3949:Vosaroxin
3929:Veliparib
3884:Sotorasib
3874:Selinexor
3868:Tretinoin
3858:Retinoids
3772:Glasdegib
3717:Celecoxib
3666:Adagrasib
3590:Duvelisib
3580:Alpelisib
3535:Rucaparib
3522:Niraparib
3463:Oprozomib
3425:Alvocidib
3291:Bleomycin
3248:Triazenes
3232:Etoglucid
3177:Cisplatin
3093:Nimustine
3087:Semustine
3083:Lomustine
3045:Melphalan
2972:Menogaril
2967:Crisnatol
2957:Amsacrine
2929:Zorubicin
2889:Amrubicin
2850:Etoposide
2825:Topotecan
2820:Silatecan
2815:Rubitecan
2800:Gimatecan
2785:Cositecan
2775:Belotecan
2451:inhibitor
2421:Tesetaxel
2411:Ortataxel
2406:Larotaxel
2401:Docetaxel
2363:Vindesine
1908:30 August
1686:Genentech
1633:does not
1089:Phenytoin
1073:brivudine
1054:brivudine
946:Hair loss
850:indicated
815:pregnancy
788:docetaxel
359:Excretion
348:half-life
317:Extensive
175:Routes of
149:Pregnancy
127:Monograph
121:Drugs.com
4058:Prodrugs
4017:Medicine
3822:Mitotane
3762:Eribulin
3530:Olaparib
3468:Ixazomib
3144:Thiotepa
3116:Busulfan
2795:Exatecan
2632:Carmofur
2340:assembly
2303: /
2262:28520372
2256:(NCBI).
2225:Archived
2203:21919607
2119:Archived
2048:Archived
2015:Archived
2011:DailyMed
1975:Archived
1926:(2019).
1902:Archived
1871:23988873
1807:Archived
1083:warfarin
942:Headache
922:Weakness
904:Vomiting
901:Diarrhea
799:diarrhea
792:by mouth
754:(verify)
459:DrugBank
327:< 60%
201:ATC code
182:By mouth
151:category
2751:S phase
2652:Tegafur
2466:S phase
2391:Taxanes
2327:M phase
1862:3831181
1693:Eurolab
1654:removed
1639:sources
1591:de novo
1172:[[File:
1116:tegafur
1031:Severe
986:anaemia
918:Fatigue
831:tegafur
676:359.354
635:Formula
468:DB01101
414:PubChem
287:Rx-only
284:WARNING
256::
217:)
211: (
209:L01BC06
164: D
141:a699003
4003:Portal
3967:WHO-EM
3576:(Pi3K)
2533:Purine
2336:Block
2260:
2201:
2161:
1894:
1869:
1859:
1774:
1752:2 July
1079:CYP2C9
932:Oedema
907:Nausea
809:, and
768:Xeloda
709:SMILES
559:ChEMBL
528:D01223
281:
268:
258:℞-only
244:
101:
3488:IMPDI
3383:Other
2111:(PDF)
2051:(PDF)
2040:(PDF)
1039:, or
1021:(see
936:Fever
729:InChI
685:JSmol
539:ChEBI
488:54916
428:60953
3574:PIKI
3542:HDAC
2991:CCNS
2258:PMID
2199:PMID
2159:ISBN
2127:2014
2094:2014
2059:2014
2023:2014
1983:2023
1910:2017
1892:ISBN
1867:PMID
1815:2016
1772:ISBN
1754:2024
1728:2023
1637:any
1635:cite
1553:edit
1540:edit
1150:and
1124:DPYD
1114:and
1106:The
996:and
939:Pain
852:for
829:and
827:5-FU
782:and
519:KEGG
499:UNII
448:6799
307:data
117:AHFS
3620:ERA
3476:PhI
3447:PrI
3412:CDK
3324:PDT
2322:MIs
2318:SPs
2309:L01
2191:doi
1932:hdl
1857:PMC
1849:doi
1721:FDA
1648:by
1130:or
584:EPA
418:CID
270:POM
214:WHO
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