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Cerebral hypoxia

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If hypoxia results in coma, the length of unconsciousness is often indicative of long-term damage. In some cases coma can give the brain an opportunity to heal and regenerate, but, in general, the longer a coma, the greater the likelihood that the person will remain in a vegetative state until death.
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applied within 6 hours of cerebral hypoxia effectively improves survival and neurological outcome. In adults, however, the evidence is less convincing and the first goal of treatment is to restore oxygen to the brain. The method of restoration depends on the cause of the hypoxia. For mild-to-moderate
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Cerebral hypoxia refers to oxygen levels in brain tissue, not blood. Blood oxygenation will usually appear normal in cases of hypemic, ischemic, and hystoxic cerebral hypoxia. Even in hypoxic hypoxia blood measures are only an approximate guide; the oxygen level in the brain tissue will depend on
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per minute. Initially the body responds to lowered blood oxygen by redirecting blood to the brain and increasing cerebral blood flow. Blood flow may increase up to twice the normal flow but no more. If the increased blood flow is sufficient to supply the brain's oxygen needs then no symptoms will
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and places the patient at increased risk for a major stroke in the future. In a broad study in 1998, more than 11 million people were estimated to have experienced a stroke in the United States. Approximately 770,000 of these strokes were symptomatic and 11 million were first-ever silent MRI
611:– Limited oxygen in the environment causes reduced brain function. Divers, aviators, mountain climbers, and fire fighters are all at risk for this kind of cerebral hypoxia. The term also includes oxygen deprivation due to obstructions in the lungs. Choking, strangulation, the crushing of the 218:
Cerebral hypoxia can be caused by any event that severely interferes with the brain's ability to receive or process oxygen. This event may be internal or external to the body. Mild and moderate forms of cerebral hypoxia may be caused by various diseases that interfere with breathing and
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of the brain (left side) typically causes problems with speech and language. Damage to the right side of the brain may interfere with the ability to express emotions or interpret what one sees. Damage on either side can cause paralysis of the opposite side of the body.
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are termed "anoxia", which can be hypoxic in origin (reduced oxygen availability) or ischemic in origin (oxygen deprivation due to a disruption in blood flow). Brain injury as a result of oxygen deprivation either due to hypoxic or anoxic mechanisms are generally termed
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Mild and moderate cerebral hypoxia may result in seizures and impaired memory going forward. The outcome of severe cerebral hypoxia will depend on the success of damage control, amount of brain tissue deprived of oxygen, and the speed with which oxygen was restored.
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Long-term comas can have a significant impact on a patient's family. Families of coma patients often have idealized images of the outcome based on Hollywood movie depictions of coma. Adjusting to the realities of ventilators, feeding tubes,
342:, slurred speech, and mental confusion. The symptoms of a TIA typically resolve within 24 hours, unlike a stroke. Brain injury may still occur in a TIA lasting only a few minutes. Having a TIA is a risk factor for eventually having a stroke. 445:
in the mother. Problems after delivery can include severe prematurity, severe lung or heart disease, serious infections, trauma to the brain or skull, congenital malformations of the brain or very low blood pressure in the baby and due to
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However, if blood flow cannot be increased or if doubled blood flow does not correct the problem, symptoms of cerebral hypoxia will begin to appear. Mild symptoms include difficulties with complex learning tasks and reductions in
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There has long been a debate over whether newborn infants with cerebral hypoxia should be resuscitated with 100% oxygen or normal air. It has been demonstrated that high concentrations of oxygen lead to generation of oxygen
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cases of hypoxia, removal of the cause of hypoxia may be sufficient. Inhaled oxygen may also be provided. In severe cases treatment may also involve life support and damage control measures.
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In severe cases it is extremely important to act quickly. Brain cells are very sensitive to reduced oxygen levels. Once deprived of oxygen they will begin to die off within five minutes.
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which does not have any outward symptoms, and the patient is typically unaware they have had a stroke. Despite its lack of identifiable symptoms, a silent stroke still causes
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Konig P, et al. (1992). "Psychological counseling of the family of patients with craniocerebral injuries (psychological family counseling of severely ill patients)"".
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Davis, PG; Tan, A; O'Donnell, CPF; Schulze, A (2004). "Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis".
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Brain damage can occur both during and after oxygen deprivation. During oxygen deprivation, cells die due to an increasing acidity in the brain tissue (
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levels, and hemodilution (thinning of the blood) coupled with drug-induced hypertension are some treatment techniques currently under investigation.
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paralysis (opposite side of body from affected brain hemisphere), or sudden weakness or numbness. A TIA may cause sudden dimming or loss of vision,
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Robinson, LR; Micklesen, PJ; Tirschwell, DL; Lew, HL (Mar 2003). "Predictive value of somatosensory evoked potentials for awakening from coma".
375:. The risk of silent stroke increases with age but may also affect younger adults. Women appear to be at increased risk for silent stroke, with 2467: 797:
If cerebral hypoxia was localized to a specific part of the brain, brain damage will be localized to that region. A general consequence may be
560:– A stroke occurring in a localized area that can either be acute or transient. This may be due to a variety of medical conditions such as an 1133: 318:(AHA/ASA) refined the definition of transient ischemic attack. TIA is now defined as a transient episode of neurologic dysfunction caused by 1601:
Pressman B. D.; Tourje E. J.; Thompson J. R. (Sep 1987). "An early CT sign of ischemic infarction: increased density in a cerebral artery".
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and others led to new international guidelines on newborn resuscitation in 2010, recommending the use of normal air instead of 100% oxygen.
2269: 102:. There are four categories of cerebral hypoxia; they are, in order of increasing severity: diffuse cerebral hypoxia (DCH), focal cerebral 1656: 3206: 3779: 3095: 813:
The effects of certain kinds of severe generalized hypoxias may take time to develop. For example, the long-term effects of serious
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Cerebral hypoxia is typically grouped into four categories depending on the severity and location of the brain's oxygen deprivation:
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A deep coma will interfere with the body's breathing reflexes even after the initial cause of hypoxia has been dealt with;
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Even if the patient wakes up, brain damage is likely to be significant enough to prevent a return to normal functioning.
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Leary M. C.; Saver J. L. (2003). "Annual incidence of first silent stroke in the United States: a preliminary estimate".
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Ferro J. M.; et al. (Dec 1996). "Diagnosis of transient ischemic attack by the nonneurologist: A validation study".
625:– Reduced brain function is caused by inadequate oxygen in the blood despite adequate environmental oxygen. Anemia and 202:
Objective measurements of the severity of cerebral hypoxia depend on the cause. Blood oxygen saturation may be used for
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Gardiner M, Eisen S, Murphy C. Training in paediatrics: the essential curriculum. Oxford University Press, Oxford 2009.
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Geraghty M. C.; Torbey M. T. (2006). "Neuroimaging and serologic markers of neurologic injury after cardiac arrest".
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Jacobs, Susan E; Berg, Marie; Hunt, Rod; Tarnow-Mordi, William O; Inder, Terrie E; Davis, Peter G (2013-01-31).
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build up. When oxygen enters the tissue these materials interact with oxygen to create high levels of oxidants.
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Details of the mechanism of damage from cerebral hypoxia, along with anoxic depolarization, can be found here:
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may be difficult. Treatment decisions often involve complex ethical choices and can strain family dynamics.
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This website provides hypoxia related safety tips for aviators working for the United States Navy aviators.
1156: 330:. The symptoms of a TIA can resolve within a few minutes, unlike a stroke. TIAs share the same underlying 3789: 3784: 3511: 3501: 2642: 716:
may all be tried in an effort to get the heart to resume pumping. Severe cerebral hypoxia can also cause
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as strokes; a disruption of cerebral blood flow. TIAs and strokes present with the same symptoms such as
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Wijdicks E. F. M.; Wijdicks C. A. (2006). "The portrayal of coma in contemporary motion pictures".
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poisoning usually may take several weeks to appear. Recent research suggests this may be due to an
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Montgomery V, et al. (2002). "The effect of severe traumatic brain injury on the family".
1660: 801:. The long-term effects will depend on the purpose of that portion of the brain. Damage to the 779: 693: 577: 62: 2235: 1146: 3932: 3677: 3536: 3528: 3496: 3383: 3022: 2896: 2714: 2692: 2607: 2530: 2440: 2427: 2352: 1962: 2033: 1196:. Maryland Institute for Emergency Medical Services Systems (2004). Retrieved on 2007-04-13. 647:
may cause stagnant hypoxia. Ischemic hypoxia can also be created by pressure on the brain.
3846: 3841: 3645: 3437: 2959: 2776: 2665: 747:). Additionally, during the period of oxygen deprivation, materials that can easily create 411: 248: 8: 3922: 3689: 2888: 2535: 2390: 2330: 2184: 1836: 737: 652: 595: 590: 327: 298: 290: 107: 554:– A mild to moderate impairment of brain function due to low oxygen levels in the blood. 3836: 3746: 3328: 3058: 3043: 3031: 2781: 2732: 2569: 2432: 2320: 2082: 2070: 1845: 1817: 1767: 1688: 1546: 1529: 1379: 1208: 1008: 996: 944:"Increased neurogenesis after hypoxic-ischemic encephalopathy in humans is age related" 924: 806: 760: 733: 667: 612: 565: 286: 282: 232: 143: 69: 2189: 1805: 3985: 3627: 3576: 3476: 2821: 2787: 2759: 2750: 2682: 2658: 2525: 2373: 2144: 2140: 2109: 2074: 1943: 1864: 1859: 1840: 1809: 1772: 1754: 1640: 1618: 1551: 1461: 1420: 1371: 1336: 1295: 1254: 1121: 1084: 1043: 1000: 965: 916: 912: 854: 672: 399: 380: 176: 87: 57: 40: 2086: 2008: 1821: 1734: 1383: 1012: 928: 671:– Oxygen is present in brain tissue but cannot be metabolized by the brain tissue. 3632: 3281: 3184: 2944: 2815: 2810: 2595: 2590: 2136: 2066: 1854: 1801: 1762: 1750: 1746: 1666: 1610: 1541: 1451: 1410: 1363: 1326: 1285: 1246: 1074: 1035: 992: 955: 908: 415: 274: 48: 1905:
Richmond, T. S. (May 1997). "Cerebral Resuscitation after Global Brain Ischemia",
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levels showing a possible reduction in the overall systemic inflammatory process.
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Cerebral hypoxia can also be classified by the cause of the reduced brain oxygen:
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Techniques for preventing damage to brain cells are an area of ongoing research.
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Severe cerebral hypoxia and anoxia is usually caused by traumatic events such as
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The severity of a neonatal hypoxic-ischaemic brain injury may be assessed using
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Orozco-Gutierrez A, Rojas-Cerda L, Estrada RM, Gil-Rosales C (December 2010).
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For newborn infants starved of oxygen during birth there is now evidence that
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is the only evidence-supported therapy, but antioxidant drugs, control of
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may be required. Additionally, severe cerebral hypoxia causes an elevated
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Floppiness, or unreactive to sights or sounds, or more tense and agitated.
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The brain requires approximately 3.3 ml of oxygen per 100 g of
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can cause some degree of diffuse cerebral hypoxia. Other causes include
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Spinal muscular atrophy with lower extremity predominance (SMALED)
2805: 2797: 2763: 2617: 2520: 1659:. Gray Laboratory Cancer Research Trust. 1999-08-01. Archived from 1483:"What You Need To Know About Hypoxic Ischemic Encephalopathy (HIE)" 1191: 874: 798: 752: 744: 717: 713: 569: 561: 419: 331: 266: 258:, and intense exercise at high altitudes prior to acclimatization. 236: 184: 180: 103: 75: 2211: 1506: 2284: 573: 339: 262: 210:
how the body deals with the reduced oxygen content of the blood.
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Hypoxic-anoxic events may affect the fetus at various stages of
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is being evaluated with the reduction in total and myocardial
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Basic Neurochemistry: Molecular, Cellular and Medical Aspects
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at the American Association of Critical-Care Nurses website.
1834: 1789: 1735:"Cooling for newborns with hypoxic ischaemic encephalopathy" 720:, which put the patient at risk of self-injury, and various 700:, and in extreme cases the heart may tire and stop pumping. 540: 3600: 619:
exacerbations may also lead to symptoms of hypoxic hypoxia.
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response caused by carbon monoxide-induced changes in the
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Norwegian paediatrician honoured by University of Athens
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Weak breathing, no breathing at all, or rapid breathing.
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National Institute of Neurological Disorders and Stroke
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drugs may need to be administered before treatment.
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Low Apgar scores, <5 at 5 minutes and 10 minutes.
310:(TIA), is often referred to as a "mini-stroke". The 1095: 2031: 1950:. Archived from the original on September 6, 2013 586:– A complete stoppage of blood flow to the brain. 568:occurring in the affected blood vessels due to a 3972: 2009:"'Rewired brain' revives patient after 19 years" 293:. It is also recreationally self-induced in the 1583:The Gale Encyclopedia of Neurological Disorders 941: 900:American Journal of Physiology. Cell Physiology 768:Hypothermia therapy for neonatal encephalopathy 686:hypothermia therapy for neonatal encephalopathy 425:Problems during labor and delivery can include 461:, which is based on clinical presentation and 3200: 2270: 1396: 1923: 1881:ILCOR Neonatal Resuscitation Guidelines 2010 1637:Animal Models of Acute Neurological Injuries 759:and cause further damage (this is known as " 2989: 1901: 1899: 1715:"Cooling 'cure' averts infant brain damage" 1527: 1437: 1312: 1236: 3780:Chronic cerebrospinal venous insufficiency 3207: 3193: 2277: 2263: 2126: 1139: 598:which affects multiple areas of the brain. 441:, prolonged late stages of labor, or very 39: 1858: 1766: 1545: 1455: 1414: 1330: 1289: 1078: 959: 942:Mattiesen W. R.; et al. (May 2009). 546:one cause of hypoxic anoxic injury (HAI). 469:. Signs and symptoms of HIE may include: 162:CT in a person after generalized hypoxia. 2006: 1896: 1562: 1175: 1173: 892: 564:that causes a hemorrhagic stroke, or an 539: 157: 1739:Cochrane Database of Systematic Reviews 1438:HerderscheĂŞ D, et al. (Sep 1992). 1397:Vermeer S. E.; et al. (Jan 2002). 1313:HerderscheĂŞ D, et al. (Sep 1992). 1204: 1202: 615:all cause this sort of hypoxia. Severe 402:, during labor and delivery and in the 118:, resulting in a hypoxic brain injury. 3973: 3066:Distal hereditary motor neuronopathies 2739:Template:Demyelinating diseases of CNS 1678: 1271: 663:and impede their absorption of oxygen. 491:Need for resuscitation after delivery. 3552:Hereditary hemorrhagic telangiectasia 3188: 2258: 2099: 1509:. Florida Neonatal Neurologic Network 1477: 1475: 1170: 629:are common causes of hypemic hypoxia. 485:Poor muscle tone and absent reflexes. 387: 326:, or retinal ischemia, without acute 153: 3557:Generalized essential telangiectasia 2917:Idiopathic intracranial hypertension 2306: 1835:Kutzsche, S; Ilves, P; Kirkeby, OJ; 1713:Laurance, Jeremy (October 1, 2009). 1199: 1061:Busl K. M.; Greer D. M. (Jan 2010). 893:Malhotra R, et al. (Nov 2001). 1691:Naval Safety Center. Archived from 1635:Jun Chen, Zao C. Xu, Xiao-Ming Xu, 1272:Easton JD, et al. (Jun 2009). 1214:"Cerebral Hypoxia Information Page" 239:-rich environments, ascent from a 187:, long-term loss of consciousness, 13: 3148:Infantile progressive bulbar palsy 2071:10.1212/01.wnl.0000210497.62202.e9 1679:Brooks, Kevin E. (May–June 2005). 1472: 997:10.1097/01.ccm.0000053643.21751.3b 523:anoxic depolarization in the brain 517:Anoxic depolarization in the brain 367:which are detected via the use of 14: 4002: 2851:Template:Cerebrovascular diseases 2654:Frontotemporal lobar degeneration 2158: 1118:Lippincott Williams & Wilkins 532: 363:. Silent strokes typically cause 3707:Cerebral venous sinus thrombosis 2871:For more detailed coverage, see 2849:For more detailed coverage, see 2820:For more detailed coverage, see 2786:For more detailed coverage, see 2737:For more detailed coverage, see 2141:10.1097/00005373-200206000-00016 2032:Mayo Clinic staff (2006-05-17). 1909:8 (2). Retrieved on 2007-04-13. 1860:10.1203/00006450-200106000-00020 1152:MedlinePlus Medical Encyclopedia 913:10.1152/ajpcell.2001.281.5.c1596 193:cessation of brain stem reflexes 74:Confusion, difficulty speaking, 2120: 2093: 2050: 2025: 2000: 1975: 1884: 1875: 1828: 1783: 1726: 1707: 1672: 1649: 1629: 1594: 1571: 1521: 1499: 1431: 1390: 1347: 1306: 1265: 1230: 1104:Butterworth, Roger F. (1999). " 503:Seizures or abnormal movements. 136:Hypoxic ischemic encephalopathy 3658:Hepatic veno-occlusive disease 2007:Phillips, Helen (2006-07-03). 1936:Diving and Hyperbaric Medicine 1751:10.1002/14651858.cd003311.pub3 1054: 1019: 976: 935: 886: 544:Aneurysm in a cerebral artery, 94:), specifically involving the 1: 3470:Aneurysm of sinus of Valsalva 3324:Monckeberg's arteriosclerosis 3164:Amyotrophic lateral sclerosis 3049:Hereditary spastic paraplegia 2907:Normal pressure hydrocephalus 1985:Medical Center (2004-09-06). 1806:10.1016/S0140-6736(04)17189-4 1665:Retrieved on 2007-04-13 from 1587:Retrieved on 2007-04-13 from 1218:National Institutes of Health 1116:, 6th edition, Philadelphia: 880: 433:, rupture of the placenta or 3775:Chronic venous insufficiency 3400:Aortoiliac occlusive disease 3133:Progressive muscular atrophy 1585:. The Gale Group, Inc. 2005. 1291:10.1161/STROKEAHA.108.192218 1157:National Library of Medicine 788: 736:after asphyxia. Research by 679: 527: 510: 500:Excessive acid in the blood. 452:MĂĽnchausen syndrome by proxy 16:Oxygen shortage of the brain 7: 3790:Inferior vena cava syndrome 3785:Superior vena cava syndrome 3512:Vertebral artery dissection 3502:Intracranial berry aneurysm 2643:Primary progressive aphasia 1916:September 27, 2007, at the 1681:"Are you a hypoxia expert?" 1639:, Humana Press; 1 edition, 848: 383:being predisposing factors. 316:American Stroke Association 10: 4007: 3891:Hypertensive heart disease 3542:Arteriovenous malformation 3517:Familial aortic dissection 2965:Hashimoto's encephalopathy 2671:Posterior cortical atrophy 2492:Striatonigral degeneration 2343:Cavernous sinus thrombosis 1983:University of Pennsylvania 1136:. Retrieved on 2007-04-13. 755:interfere with the normal 514: 497:Bluish or pale skin color. 391: 312:American Heart Association 18: 3946: 3916:Renovascular hypertension 3881: 3872: 3859:Hepatic artery thrombosis 3807: 3767: 3722: 3626: 3608: 3599: 3567: 3527: 3507:Carotid artery dissection 3460:Abdominal aortic aneurysm 3432: 3392: 3369: 3310:Intermittent claudication 3280: 3273:Peripheral artery disease 3271: 3241: 3223: 3071:Spinal muscular atrophies 3039:Primary lateral sclerosis 3021: 2998: 2982: 2937: 2897:Intracranial hypertension 2887: 2859: 2830: 2796: 2758: 2747: 2713: 2691: 2677:Creutzfeldt–Jakob disease 2616: 2426: 2417: 2403: 2363: 2297: 2221: 2166: 1967:: CS1 maint: unfit URL ( 1251:10.1161/01.STR.27.12.2225 1108:". In: Siegel, George J. 1040:10.1016/j.ncl.2005.10.006 961:10.1007/s00401-009-0509-0 776:Hyperbaric oxygen therapy 627:carbon monoxide poisoning 465:findings, and also using 307:Transient ischemic attack 213: 68: 56: 47: 38: 33: 3901:Hypertensive nephropathy 3714:Post-thrombotic syndrome 3695:Paget–Schroetter disease 3487:Coronary artery aneurysm 3465:Thoracic aortic aneurysm 3138:Progressive bulbar palsy 2929:Intracranial hypotension 2912:Choroid plexus papilloma 2326:Herpesviral encephalitis 1457:10.1161/01.str.23.9.1220 1332:10.1161/01.str.23.9.1220 675:is a well-known example. 584:Global cerebral ischemia 552:Diffuse cerebral hypoxia 3956:Orthostatic hypotension 3938:White coat hypertension 3415:Fibromuscular dysplasia 3379:Carotid artery stenosis 2650:Frontotemporal dementia 2336:Encephalitis lethargica 732:, which have a role in 572:(thrombotic stroke) or 558:Focal cerebral ischemia 394:Neonatal encephalopathy 128:hypoxic/anoxic injuries 3928:Pulmonary hypertension 3911:Secondary hypertension 3906:Essential hypertension 3896:Hypertensive emergency 3737:Portacaval anastomosis 3673:Portal vein thrombosis 3315:Critical limb ischemia 3216:Cardiovascular disease 2955:Hepatic encephalopathy 1106:Hypoxic Encephalopathy 985:Critical Care Medicine 780:creatine phosphokinase 694:mechanical ventilation 578:middle cerebral artery 547: 429:occlusion, torsion or 163: 63:Critical care medicine 52:Arteries beneath brain 3933:Systolic hypertension 3678:Renal vein thrombosis 3537:Arteriovenous fistula 3529:Vascular malformation 3497:Intracranial aneurysm 3384:Renal artery stenosis 3013:Ataxia–telangiectasia 2970:Static encephalopathy 2693:Mitochondrial disease 2531:Spasmodic torticollis 2441:Basal ganglia disease 2034:"Coma: Coping skills" 1615:10.2214/ajr.149.3.583 1534:Paediatr Child Health 1416:10.1161/hs0102.101629 1080:10.3233/NRE-2010-0531 543: 392:Further information: 227:and various sorts of 161: 3847:Paradoxical embolism 3842:Cholesterol embolism 3668:May–Thurner syndrome 3663:Budd–Chiari syndrome 3646:Deep vein thrombosis 3641:primarily lower limb 3420:Raynaud's phenomenon 2960:Toxic encephalopathy 2666:Lewy bodies dementia 1907:AACN Clinical Issues 1528:Bellemare S (2006). 19:For other uses, see 3923:Benign hypertension 3008:Friedreich's ataxia 2391:Meningoencephalitis 2331:Limbic encephalitis 2102:Zentralbl Neurochir 1800:(9442): 1329–1333. 1603:AJR Am J Roentgenol 1067:NeuroRehabilitation 825:sheath surrounding 738:Ola Didrik Saugstad 596:cerebral blood flow 591:Cerebral infarction 482:Low blood pressure. 299:erotic asphyxiation 256:supplemental oxygen 108:cerebral infarction 90:(reduced supply of 3837:Pulmonary embolism 3747:Esophageal varices 3685:upper limb / torso 3329:Arteriolosclerosis 3044:Pseudobulbar palsy 2782:Status epilepticus 2733:Multiple sclerosis 2570:Myoclonic epilepsy 2433:movement disorders 2379:Acute disseminated 2321:Viral encephalitis 2250:Hypoxia experiment 2222:External resources 1846:Pediatric Research 1689:United States Navy 1657:"What is Hypoxia?" 1487:Birth Injury Guide 1147:"Cerebral hypoxia" 907:(5): C1596–C1603. 761:reperfusion injury 734:reperfusion injury 668:Histotoxic hypoxia 659:exert pressure on 548: 443:low blood pressure 388:Pre- and postnatal 287:status asthmaticus 281:, crushing of the 233:status epilepticus 164: 154:Signs and symptoms 123:oxygen deprivation 3968: 3967: 3964: 3963: 3808:Arteries or veins 3803: 3802: 3628:Venous thrombosis 3595: 3594: 3577:Cherry hemangioma 3477:Aortic dissection 3428: 3427: 3263:Buerger's disease 3182: 3181: 3178: 3177: 3174: 3173: 2978: 2977: 2883: 2882: 2822:Template:Headache 2788:Template:Epilepsy 2709: 2708: 2683:Vascular dementia 2526:Status dystonicus 2399: 2398: 2374:Encephalomyelitis 2245: 2244: 2129:Journal of Trauma 1645:978-1-60327-184-4 1368:10.1159/000071128 1245:(12): 2225–2229. 855:Altitude sickness 673:Cyanide poisoning 653:brain hemorrhages 412:maternal diabetes 400:fetal development 381:cigarette smoking 221:blood oxygenation 177:short-term memory 81: 80: 28:Medical condition 3998: 3879: 3878: 3690:Mondor's disease 3633:Thrombophlebitis 3606: 3605: 3282:Arteriosclerosis 3278: 3277: 3239: 3238: 3209: 3202: 3195: 3186: 3185: 2996: 2995: 2987: 2986: 2945:Brain herniation 2756: 2755: 2596:Intention tremor 2591:Essential tremor 2456:Postencephalitic 2424: 2423: 2415: 2414: 2304: 2303: 2285:Diseases of the 2279: 2272: 2265: 2256: 2255: 2164: 2163: 2153: 2152: 2135:(6): 1121–1124. 2124: 2118: 2117: 2097: 2091: 2090: 2065:(9): 1300–1303. 2054: 2048: 2047: 2045: 2044: 2029: 2023: 2022: 2020: 2019: 2004: 1998: 1997: 1995: 1994: 1979: 1973: 1972: 1966: 1958: 1956: 1955: 1927: 1921: 1903: 1894: 1888: 1882: 1879: 1873: 1872: 1862: 1832: 1826: 1825: 1787: 1781: 1780: 1770: 1730: 1724: 1711: 1705: 1703: 1701: 1700: 1676: 1670: 1664: 1653: 1647: 1633: 1627: 1626: 1598: 1592: 1586: 1575: 1569: 1566: 1560: 1559: 1549: 1525: 1519: 1518: 1516: 1514: 1503: 1497: 1496: 1494: 1493: 1479: 1470: 1469: 1459: 1450:(9): 1220–1224. 1435: 1429: 1428: 1418: 1394: 1388: 1387: 1351: 1345: 1344: 1334: 1325:(9): 1220–1224. 1310: 1304: 1303: 1293: 1284:(6): 2276–2293. 1269: 1263: 1262: 1234: 1228: 1227: 1225: 1224: 1206: 1197: 1195: 1187: 1185: 1177: 1168: 1167: 1165: 1164: 1143: 1137: 1130:Freely available 1102: 1093: 1092: 1082: 1058: 1052: 1051: 1023: 1017: 1016: 980: 974: 973: 963: 948:Acta Neuropathol 939: 933: 932: 890: 633:Ischemic hypoxia 506:Problems feeding 416:vascular disease 404:postnatal period 275:smoke inhalation 84:Cerebral hypoxia 49:Circle of Willis 43: 34:Cerebral hypoxia 31: 30: 4006: 4005: 4001: 4000: 3999: 3997: 3996: 3995: 3981:Brain disorders 3971: 3970: 3969: 3960: 3942: 3868: 3825:Microangiopathy 3820:Macroangiopathy 3799: 3763: 3732:Gastric varices 3718: 3631: 3622: 3591: 3563: 3523: 3455:Aortic aneurysm 3441: 3424: 3410:Erythromelalgia 3388: 3365: 3290:Atherosclerosis 3267: 3231: 3219: 3213: 3183: 3170: 3096:Congenital DSMA 3017: 2974: 2933: 2879: 2867:Sleep disorders 2855: 2832:Cerebrovascular 2826: 2792: 2749: 2743: 2705: 2687: 2612: 2558:Choreoathetosis 2431: 2408: 2395: 2359: 2293: 2283: 2246: 2241: 2240: 2217: 2216: 2175: 2161: 2156: 2125: 2121: 2098: 2094: 2055: 2051: 2042: 2040: 2030: 2026: 2017: 2015: 2005: 2001: 1992: 1990: 1980: 1976: 1960: 1959: 1953: 1951: 1928: 1924: 1918:Wayback Machine 1904: 1897: 1889: 1885: 1880: 1876: 1833: 1829: 1788: 1784: 1745:(1): CD003311. 1731: 1727: 1720:The Independent 1712: 1708: 1698: 1696: 1677: 1673: 1655: 1654: 1650: 1634: 1630: 1599: 1595: 1577: 1576: 1572: 1567: 1563: 1526: 1522: 1512: 1510: 1505: 1504: 1500: 1491: 1489: 1481: 1480: 1473: 1436: 1432: 1395: 1391: 1356:Cerebrovasc Dis 1352: 1348: 1311: 1307: 1270: 1266: 1235: 1231: 1222: 1220: 1207: 1200: 1189: 1183: 1179: 1178: 1171: 1162: 1160: 1145: 1144: 1140: 1103: 1096: 1059: 1055: 1024: 1020: 981: 977: 940: 936: 891: 887: 883: 865:Hypothermia cap 851: 815:carbon monoxide 807:Wernicke's area 791: 757:brain chemistry 722:anti-convulsant 682: 623:Hypemic hypoxia 608:Hypoxic hypoxia 545: 535: 530: 519: 513: 479:Low heart rate. 439:breech position 396: 390: 241:deep-water dive 216: 204:hypoxic hypoxia 156: 121:Cases of total 114:cell death via 100:cerebral anoxia 51: 29: 24: 17: 12: 11: 5: 4004: 3994: 3993: 3988: 3983: 3966: 3965: 3962: 3961: 3959: 3958: 3952: 3950: 3944: 3943: 3941: 3940: 3935: 3930: 3925: 3920: 3919: 3918: 3908: 3903: 3898: 3893: 3887: 3885: 3876: 3874:Blood pressure 3870: 3869: 3867: 3866: 3861: 3856: 3851: 3850: 3849: 3844: 3839: 3829: 3828: 3827: 3822: 3811: 3809: 3805: 3804: 3801: 3800: 3798: 3797: 3792: 3787: 3782: 3777: 3771: 3769: 3765: 3764: 3762: 3761: 3756: 3755: 3754: 3749: 3744: 3734: 3728: 3726: 3724:Varicose veins 3720: 3719: 3717: 3716: 3711: 3710: 3709: 3699: 3698: 3697: 3692: 3682: 3681: 3680: 3675: 3670: 3665: 3660: 3650: 3649: 3648: 3637: 3635: 3624: 3623: 3621: 3620: 3614: 3612: 3603: 3597: 3596: 3593: 3592: 3590: 3589: 3587:Spider angioma 3584: 3579: 3573: 3571: 3569:Vascular nevus 3565: 3564: 3562: 3561: 3560: 3559: 3554: 3547:Telangiectasia 3544: 3539: 3533: 3531: 3525: 3524: 3522: 3521: 3520: 3519: 3514: 3509: 3504: 3499: 3489: 3484: 3482:Aortic rupture 3479: 3474: 3473: 3472: 3467: 3462: 3447: 3445: 3443:pseudoaneurysm 3430: 3429: 3426: 3425: 3423: 3422: 3417: 3412: 3407: 3402: 3396: 3394: 3390: 3389: 3387: 3386: 3381: 3375: 3373: 3367: 3366: 3364: 3363: 3362: 3361: 3356: 3354:Oxycholesterol 3351: 3346: 3341: 3336: 3326: 3320: 3319: 3318: 3317: 3312: 3307: 3302: 3297: 3286: 3284: 3275: 3269: 3268: 3266: 3265: 3260: 3259: 3258: 3247: 3245: 3236: 3221: 3220: 3212: 3211: 3204: 3197: 3189: 3180: 3179: 3176: 3175: 3172: 3171: 3169: 3168: 3167: 3166: 3155: 3154: 3153: 3152: 3151: 3150: 3145: 3135: 3130: 3129: 3128: 3123: 3118: 3117: 3116: 3111: 3106: 3098: 3093: 3088: 3083: 3078: 3068: 3054: 3053: 3052: 3051: 3046: 3041: 3027: 3025: 3019: 3018: 3016: 3015: 3010: 3004: 3002: 2993: 2984: 2980: 2979: 2976: 2975: 2973: 2972: 2967: 2962: 2957: 2952: 2947: 2941: 2939: 2935: 2934: 2932: 2931: 2926: 2924:Cerebral edema 2921: 2920: 2919: 2914: 2909: 2904: 2893: 2891: 2885: 2884: 2881: 2880: 2878: 2877: 2876: 2875: 2873:Template:Sleep 2863: 2861: 2857: 2856: 2854: 2853: 2847: 2842: 2836: 2834: 2828: 2827: 2825: 2824: 2818: 2813: 2808: 2802: 2800: 2794: 2793: 2791: 2790: 2784: 2779: 2774: 2768: 2766: 2753: 2745: 2744: 2742: 2741: 2735: 2730: 2725: 2719: 2717: 2711: 2710: 2707: 2706: 2704: 2703: 2701:Leigh syndrome 2697: 2695: 2689: 2688: 2686: 2685: 2674: 2673: 2668: 2663: 2662: 2661: 2647: 2646: 2645: 2640: 2639: 2638: 2622: 2620: 2614: 2613: 2611: 2610: 2605: 2600: 2599: 2598: 2593: 2582: 2581: 2580: 2579: 2574: 2573: 2572: 2562: 2561: 2560: 2550: 2545: 2544: 2543: 2538: 2533: 2528: 2512: 2511: 2510: 2509: 2504: 2499: 2494: 2489: 2488: 2487: 2477: 2476: 2475: 2465: 2464: 2463: 2458: 2453: 2437: 2435: 2428:Extrapyramidal 2421: 2412: 2410:encephalopathy 2401: 2400: 2397: 2396: 2394: 2393: 2388: 2383: 2382: 2381: 2370: 2368: 2361: 2360: 2358: 2357: 2356: 2355: 2345: 2340: 2339: 2338: 2333: 2328: 2323: 2312: 2310: 2301: 2295: 2294: 2287:nervous system 2282: 2281: 2274: 2267: 2259: 2253: 2252: 2243: 2242: 2239: 2238: 2226: 2225: 2223: 2219: 2218: 2215: 2214: 2203: 2192: 2176: 2171: 2170: 2168: 2167:Classification 2160: 2159:External links 2157: 2155: 2154: 2119: 2092: 2049: 2024: 1999: 1989:. ScienceDaily 1974: 1942:(4): 218–220. 1922: 1911:Free full text 1895: 1883: 1874: 1853:(6): 834–842. 1827: 1782: 1725: 1706: 1671: 1663:on 2003-09-21. 1648: 1628: 1593: 1570: 1561: 1540:(8): 493–495. 1520: 1498: 1471: 1430: 1389: 1362:(3): 280–285. 1346: 1305: 1264: 1229: 1212:(2018-03-08). 1198: 1169: 1138: 1134:NCBI Bookshelf 1094: 1053: 1034:(1): 107–121. 1018: 991:(3): 960–967. 975: 954:(5): 525–534. 934: 884: 882: 879: 878: 877: 872: 870:Space exposure 867: 862: 857: 850: 847: 843:muscle wasting 790: 787: 681: 678: 677: 676: 664: 649:Cerebral edema 641:cardiac arrest 630: 620: 600: 599: 587: 581: 555: 534: 533:Classification 531: 529: 526: 515:Main article: 512: 509: 508: 507: 504: 501: 498: 495: 492: 489: 486: 483: 480: 477: 474: 459:Sarnat staging 427:umbilical cord 389: 386: 385: 384: 343: 279:drug overdoses 245:high altitudes 215: 212: 155: 152: 148:cardiac arrest 144:birth asphyxia 79: 78: 72: 66: 65: 60: 54: 53: 45: 44: 36: 35: 27: 15: 9: 6: 4: 3: 2: 4003: 3992: 3989: 3987: 3984: 3982: 3979: 3978: 3976: 3957: 3954: 3953: 3951: 3949: 3945: 3939: 3936: 3934: 3931: 3929: 3926: 3924: 3921: 3917: 3914: 3913: 3912: 3909: 3907: 3904: 3902: 3899: 3897: 3894: 3892: 3889: 3888: 3886: 3884: 3880: 3877: 3875: 3871: 3865: 3862: 3860: 3857: 3855: 3852: 3848: 3845: 3843: 3840: 3838: 3835: 3834: 3833: 3830: 3826: 3823: 3821: 3818: 3817: 3816: 3813: 3812: 3810: 3806: 3796: 3793: 3791: 3788: 3786: 3783: 3781: 3778: 3776: 3773: 3772: 3770: 3766: 3760: 3757: 3753: 3750: 3748: 3745: 3743: 3742:Caput medusae 3740: 3739: 3738: 3735: 3733: 3730: 3729: 3727: 3725: 3721: 3715: 3712: 3708: 3705: 3704: 3703: 3700: 3696: 3693: 3691: 3688: 3687: 3686: 3683: 3679: 3676: 3674: 3671: 3669: 3666: 3664: 3661: 3659: 3656: 3655: 3654: 3651: 3647: 3644: 3643: 3642: 3639: 3638: 3636: 3634: 3629: 3625: 3619: 3616: 3615: 3613: 3611: 3607: 3604: 3602: 3598: 3588: 3585: 3583: 3580: 3578: 3575: 3574: 3572: 3570: 3566: 3558: 3555: 3553: 3550: 3549: 3548: 3545: 3543: 3540: 3538: 3535: 3534: 3532: 3530: 3526: 3518: 3515: 3513: 3510: 3508: 3505: 3503: 3500: 3498: 3495: 3494: 3493: 3490: 3488: 3485: 3483: 3480: 3478: 3475: 3471: 3468: 3466: 3463: 3461: 3458: 3457: 3456: 3452: 3449: 3448: 3446: 3444: 3439: 3435: 3431: 3421: 3418: 3416: 3413: 3411: 3408: 3406: 3405:Degos disease 3403: 3401: 3398: 3397: 3395: 3391: 3385: 3382: 3380: 3377: 3376: 3374: 3372: 3368: 3360: 3357: 3355: 3352: 3350: 3347: 3345: 3342: 3340: 3337: 3335: 3332: 3331: 3330: 3327: 3325: 3322: 3321: 3316: 3313: 3311: 3308: 3306: 3303: 3301: 3298: 3296: 3293: 3292: 3291: 3288: 3287: 3285: 3283: 3279: 3276: 3274: 3270: 3264: 3261: 3257: 3254: 3253: 3252: 3249: 3248: 3246: 3244: 3240: 3237: 3235: 3230: 3226: 3222: 3217: 3210: 3205: 3203: 3198: 3196: 3191: 3190: 3187: 3165: 3162: 3161: 3160: 3157: 3156: 3149: 3146: 3144: 3141: 3140: 3139: 3136: 3134: 3131: 3127: 3124: 3122: 3119: 3115: 3112: 3110: 3107: 3105: 3102: 3101: 3099: 3097: 3094: 3092: 3089: 3087: 3084: 3082: 3079: 3077: 3074: 3073: 3072: 3069: 3067: 3064: 3063: 3062: 3060: 3056: 3055: 3050: 3047: 3045: 3042: 3040: 3037: 3036: 3035: 3033: 3029: 3028: 3026: 3024: 3020: 3014: 3011: 3009: 3006: 3005: 3003: 3001: 2997: 2994: 2992: 2988: 2985: 2981: 2971: 2968: 2966: 2963: 2961: 2958: 2956: 2953: 2951: 2950:Reye syndrome 2948: 2946: 2943: 2942: 2940: 2936: 2930: 2927: 2925: 2922: 2918: 2915: 2913: 2910: 2908: 2905: 2903: 2902:Hydrocephalus 2900: 2899: 2898: 2895: 2894: 2892: 2890: 2886: 2874: 2870: 2869: 2868: 2865: 2864: 2862: 2858: 2852: 2848: 2846: 2843: 2841: 2838: 2837: 2835: 2833: 2829: 2823: 2819: 2817: 2814: 2812: 2809: 2807: 2804: 2803: 2801: 2799: 2795: 2789: 2785: 2783: 2780: 2778: 2775: 2773: 2770: 2769: 2767: 2765: 2761: 2757: 2754: 2752: 2746: 2740: 2736: 2734: 2731: 2729: 2726: 2724: 2721: 2720: 2718: 2716: 2715:Demyelinating 2712: 2702: 2699: 2698: 2696: 2694: 2690: 2684: 2681: 2680: 2679: 2678: 2672: 2669: 2667: 2664: 2660: 2657: 2656: 2655: 2651: 2648: 2644: 2641: 2637: 2634: 2633: 2632: 2629: 2628: 2627: 2624: 2623: 2621: 2619: 2615: 2609: 2606: 2604: 2603:Restless legs 2601: 2597: 2594: 2592: 2589: 2588: 2587: 2584: 2583: 2578: 2575: 2571: 2568: 2567: 2566: 2563: 2559: 2556: 2555: 2554: 2551: 2549: 2546: 2542: 2541:Blepharospasm 2539: 2537: 2534: 2532: 2529: 2527: 2524: 2523: 2522: 2519: 2518: 2517: 2514: 2513: 2508: 2505: 2503: 2500: 2498: 2497:Hemiballismus 2495: 2493: 2490: 2486: 2483: 2482: 2481: 2478: 2474: 2471: 2470: 2469: 2466: 2462: 2459: 2457: 2454: 2452: 2449: 2448: 2447: 2444: 2443: 2442: 2439: 2438: 2436: 2434: 2429: 2425: 2422: 2420: 2416: 2413: 2411: 2406: 2402: 2392: 2389: 2387: 2384: 2380: 2377: 2376: 2375: 2372: 2371: 2369: 2367: 2362: 2354: 2351: 2350: 2349: 2348:Brain abscess 2346: 2344: 2341: 2337: 2334: 2332: 2329: 2327: 2324: 2322: 2319: 2318: 2317: 2314: 2313: 2311: 2309: 2305: 2302: 2300: 2296: 2292: 2288: 2280: 2275: 2273: 2268: 2266: 2261: 2260: 2257: 2251: 2248: 2247: 2237: 2233: 2232: 2228: 2227: 2224: 2220: 2213: 2209: 2208: 2204: 2202: 2198: 2197: 2193: 2191: 2187: 2186: 2182: 2178: 2177: 2174: 2169: 2165: 2150: 2146: 2142: 2138: 2134: 2130: 2123: 2115: 2111: 2107: 2103: 2096: 2088: 2084: 2080: 2076: 2072: 2068: 2064: 2060: 2053: 2039: 2035: 2028: 2014: 2013:New Scientist 2010: 2003: 1988: 1984: 1978: 1970: 1964: 1949: 1945: 1941: 1937: 1933: 1926: 1919: 1915: 1912: 1908: 1902: 1900: 1892: 1887: 1878: 1870: 1866: 1861: 1856: 1852: 1848: 1847: 1842: 1838: 1831: 1823: 1819: 1815: 1811: 1807: 1803: 1799: 1795: 1794: 1786: 1778: 1774: 1769: 1764: 1760: 1756: 1752: 1748: 1744: 1740: 1736: 1729: 1722: 1721: 1716: 1710: 1695:on 2007-02-08 1694: 1690: 1686: 1682: 1675: 1668: 1662: 1658: 1652: 1646: 1642: 1638: 1632: 1624: 1620: 1616: 1612: 1609:(3): 583–56. 1608: 1604: 1597: 1590: 1584: 1580: 1574: 1565: 1557: 1553: 1548: 1543: 1539: 1535: 1531: 1524: 1508: 1507:"Parent Info" 1502: 1488: 1484: 1478: 1476: 1467: 1463: 1458: 1453: 1449: 1445: 1441: 1434: 1426: 1422: 1417: 1412: 1408: 1404: 1400: 1393: 1385: 1381: 1377: 1373: 1369: 1365: 1361: 1357: 1350: 1342: 1338: 1333: 1328: 1324: 1320: 1316: 1309: 1301: 1297: 1292: 1287: 1283: 1279: 1275: 1268: 1260: 1256: 1252: 1248: 1244: 1240: 1233: 1219: 1215: 1211: 1205: 1203: 1193: 1182: 1176: 1174: 1158: 1154: 1153: 1148: 1142: 1135: 1131: 1127: 1126:0-397-51820-X 1123: 1119: 1115: 1111: 1107: 1101: 1099: 1090: 1086: 1081: 1076: 1072: 1068: 1064: 1057: 1049: 1045: 1041: 1037: 1033: 1029: 1022: 1014: 1010: 1006: 1002: 998: 994: 990: 986: 979: 971: 967: 962: 957: 953: 949: 945: 938: 930: 926: 922: 918: 914: 910: 906: 902: 901: 896: 889: 885: 876: 873: 871: 868: 866: 863: 861: 858: 856: 853: 852: 846: 844: 840: 834: 830: 828: 824: 820: 816: 811: 808: 804: 800: 795: 786: 783: 781: 777: 773: 772:blood glucose 769: 764: 762: 758: 754: 750: 749:free radicals 746: 741: 739: 735: 731: 730:free radicals 725: 723: 719: 715: 711: 707: 706:defibrilation 703: 699: 695: 690: 687: 674: 670: 669: 665: 662: 658: 657:hydrocephalus 654: 650: 646: 642: 638: 634: 631: 628: 624: 621: 618: 614: 610: 609: 605: 604: 603: 597: 593: 592: 588: 585: 582: 579: 575: 571: 567: 563: 559: 556: 553: 550: 549: 542: 538: 525: 524: 518: 505: 502: 499: 496: 493: 490: 487: 484: 481: 478: 475: 472: 471: 470: 468: 464: 460: 455: 453: 449: 444: 440: 436: 432: 428: 423: 421: 417: 413: 409: 405: 401: 395: 382: 378: 374: 370: 366: 362: 357: 353: 349: 348: 347:Silent stroke 344: 341: 337: 336:contralateral 333: 329: 325: 321: 317: 313: 309: 308: 304: 303: 302: 300: 296: 295:fainting game 292: 288: 284: 280: 276: 272: 271:strangulation 268: 264: 259: 257: 253: 250: 249:unpressurized 246: 242: 238: 234: 230: 226: 222: 211: 207: 205: 200: 198: 194: 190: 186: 182: 178: 172: 169: 160: 151: 149: 145: 141: 137: 133: 129: 124: 119: 117: 113: 109: 105: 101: 97: 93: 89: 86:is a form of 85: 77: 73: 71: 67: 64: 61: 59: 55: 50: 46: 42: 37: 32: 26: 22: 3883:Hypertension 3795:Venous ulcer 3701: 3684: 3652: 3640: 3610:Inflammation 3491: 3450: 3339:Hyperplastic 3300:Fatty streak 3243:Inflammation 3158: 3057: 3030: 2991:Degenerative 2728:Inflammatory 2675: 2608:Stiff-person 2446:Parkinsonism 2419:Degenerative 2316:Encephalitis 2299:Inflammation 2289:, primarily 2229: 2205: 2194: 2179: 2132: 2128: 2122: 2108:(2): 78–84. 2105: 2101: 2095: 2062: 2058: 2052: 2041:. 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Index

Hypoxia

Circle of Willis
Specialty
Critical care medicine
Symptoms
seizures
hypoxia
oxygen
brain
ischemia
cerebral infarction
neuronal
apoptosis
oxygen deprivation
birth asphyxia
cardiac arrest

brain tissue
short-term memory
cyanosis
fainting
coma
cessation of brain stem reflexes
brain death
hypoxic hypoxia
blood oxygenation
asthma
anemia
status epilepticus

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