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Chalcones and their derivatives demonstrate a wide range of biological activities including anti-inflammation. Some 2′-amino chalcones have been studied as potential antitumor agents. Chalcones are of interest in
855:
Song, Dong-mee; Jung, Kyoung-Hoon; Moon, Ji-hye; Shin, Dong-Myung (2003). "Photochemistry of chalcone and the application of chalcone-derivatives in photo-alignment layer of liquid crystal display".
1039:
Xia, Yi; Yang, Zheng-Yu; Xia, Peng; Bastow, Kenneth F.; Nakanishi, Yuka; Lee, Kuo-Hsiung (2000). "Antitumor agents. Part 202: Novel 2′-amino chalcones: design, synthesis and biological evaluation".
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Santos, Mariana B.; Pinhanelli, Vitor C.; Garcia, Mayara A.R.; Silva, Gabriel; Baek, Seung J.; França, Suzelei C.; Fachin, Ana L.; Marins, Mozart; Regasini, Luis O. (2017).
712:
1004:
Mahapatra, Debarshi Kar; Bharti, Sanjay Kumar; Asati, Vivek (2017). "Chalcone
Derivatives: Anti-inflammatory Potential and Molecular Targets Perspectives".
500:
828:
Tomás-Barberán, Francisco A.; Clifford, Michael N. (2000). "Flavanones, Chalcones and
Dihydrochalcones - Nature, Occurrence and Dietary Burden".
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841:
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This reaction, which can be carried out without any solvent, is so reliable that it is often given as an example of
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Zhuang, Chunlin; Zhang, Wen; Sheng, Chunquan; Zhang, Wannian; Xing, Chengguo; Miao, Zhenyuan (28 June 2017).
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1084:"Antiproliferative and pro-apoptotic activities of 2′- and 4′-aminochalcones against tumor canine cells"
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Chalcones have been used as intermediates in heterocyclic synthesis, especially in the synthesis of
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793:
Nomenclature of
Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book)
550:. They are widely known bioactive substances, fluorescent materials, and chemical intermediates.
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546:. A variety of important biological compounds are known collectively as chalcones or
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10.1002/(SICI)1097-0010(20000515)80:7<1073::AID-JSFA568>3.0.CO;2-B
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Chalcones have two absorption maxima at 280 nm and 340 nm.
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InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H
1185:
Nayak, Yogeesha N.; Gaonkar, Santosh L.; Sabu, Mariya (2023-01-04).
1142:
Nayak, Yogeesha N.; Gaonkar, Santosh L.; Sabu, Mariya (2023-01-04).
477:
Except where otherwise noted, data are given for materials in their
348:
InChI=1/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H
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39:
969:
Palleros, Daniel R (2004). "Solvent-Free
Synthesis of Chalcones".
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1187:"Chalcones: Versatile intermediates in heterocyclic synthesis"
1144:"Chalcones: Versatile intermediates in heterocyclic synthesis"
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166:
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1081:
942:
E. P. Kohler, H. M. Chadwell (1922). "Benzalacetophenone".
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345 to 348 °C (653 to 658 °F; 618 to 621 K)
30:
895:"Chalcone: A Privileged Structure in Medicinal Chemistry"
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of these compounds. The enzyme is found in all "higher" (
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55 to 57 °C (131 to 135 °F; 328 to 330 K)
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1006:Current Topics in Medicinal Chemistry
341:Key: DQFBYFPFKXHELB-UHFFFAOYSA-N
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602:Chalcone is usually prepared by an
351:Key: DQFBYFPFKXHELB-UHFFFAOYAP
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13:
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1191:Journal of Heterocyclic Chemistry
1148:Journal of Heterocyclic Chemistry
1018:10.2174/1568026617666170914160446
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618:
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399:
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29:
1178:
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664:, chalcones have been used as:
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481:(at 25 °C , 100 kPa).
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797:The Royal Society of Chemistry
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1053:10.1016/S0960-894X(00)00072-X
971:Journal of Chemical Education
877:10.1016/S0925-3467(02)00220-3
762:
643:and have been described as a
570:are synthesized in plants as
73:)-1,3-Diphenylprop-2-en-1-one
1103:10.1016/j.ejmech.2017.06.049
630:in undergraduate education.
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911:10.1021/acs.chemrev.7b00020
805:10.1039/9781849733069-FP001
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757:Juliá–Colonna epoxidation
735:Uses in organic chemistry
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16:For the butterflies, see
1232:Chalcone on reference.md
956:10.15227/orgsyn.002.0001
372:O=C(C=Cc1ccccc1)c2ccccc2
650:
590:) and several "lower" (
465:Magnetic susceptibility
84:Benzylideneacetophenone
634:Potential pharmacology
544:α,β-unsaturated ketone
799:. 2014. p. 722.
572:secondary metabolites
65:Systematic IUPAC name
723:corrosion inhibitors
598:Laboratory synthesis
93:-phenylacrylophenone
86:Phenyl styryl ketone
53:Preferred IUPAC name
983:2004JChEd..81.1345P
869:2003OptMa..21..667S
662:medicinal chemistry
645:privileged scaffold
641:medicinal chemistry
580:polyketide synthase
554:Chemical properties
420: g·mol
25:
1237:2020-09-25 at the
991:10.1021/ed081p1345
713:chemical scaffolds
689:antimalarial drugs
679:antidiabetic drugs
604:aldol condensation
508:Infobox references
428:pale yellow solid
88:benzalacetophenone
23:
18:Chalcone (skipper)
1199:10.1002/jhet.4617
1156:10.1002/jhet.4617
1012:(28): 3146–3169.
944:Organic Syntheses
905:(12): 7762–7810.
857:Optical Materials
814:978-0-85404-182-4
674:Anticancer agents
576:chalcone synthase
516:Chemical compound
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471:-125.7·10 cm/mol
294:CompTox Dashboard
178:Interactive image
119:-benzoylethylene.
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125:Identifiers
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80:Other names
70:
1254:Chalconoids
1097:: 884–889.
977:(9): 1345.
776:Merck Index
710:fluorescent
568:chalconoids
548:chalconoids
542:. It is an
438:1.071 g/cm
425:Appearance
381:Properties
236:100.002.119
198:CHEBI:27618
156:)-Chalcone)
1248:Categories
763:References
594:) plants.
534:C(O)CH=CHC
413:Molar mass
282:5S5A2Q39HX
209:ChemSpider
165:3D model (
132:CAS Number
110:-propylene
106:-diphenyl-
1215:255212828
1207:0022-152X
1172:255212828
1164:0022-152X
1121:0223-5234
1061:0960-894X
741:pyrazoles
691:and more.
24:Chalcone
1235:Archived
1129:28738308
1069:10782667
1026:28914193
929:28488435
751:See also
606:between
588:vascular
520:Chalcone
467:(χ)
152: ((
149:614-47-1
115:-phenyl-
82:Chalkone
57:Chalcone
979:Bibcode
920:6131713
865:Bibcode
745:aurones
522:is the
501:what is
499: (
434:Density
418:208.260
249:PubChem
142:94-41-7
1264:Enones
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365:SMILES
262:637760
47:Names
1211:S2CID
1168:S2CID
1087:(PDF)
950:: 1.
330:InChI
189:ChEBI
167:JSmol
98:-oxo-
1203:ISSN
1160:ISSN
1125:PMID
1117:ISSN
1065:PMID
1057:ISSN
1022:PMID
925:PMID
809:ISBN
780:2028
743:and
651:Uses
610:and
273:UNII
218:6921
1195:doi
1152:doi
1107:hdl
1099:doi
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1049:doi
1014:doi
987:doi
952:doi
915:PMC
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660:In
299:EPA
252:CID
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491:N
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400:H
394:C
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297:(
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154:E
117:β
113:α
108:α
104:γ
102:,
100:α
96:γ
91:β
71:E
20:.
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