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littered with empty
Chlorodyne bottles. Over the decades of the twentieth century, the cannabis was removed from the formulation, and the amount of opiates in the medicine were progressively reduced. The name of Collis Browne lives on in Britain in a mixture sold under the trade name "J Collis
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Between 1861 and 1862 The
British Medical Journal featured several pieces of criticism of chlorodyne including one lead article that featured it as an example of "Professional Testimonial-Mongers." Alongside this are two letters from practising doctors. Both include significant distaste at the
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Besides the generics, a number of rival sellers marketed their own branded versions of the formula, brands such as "Freeman's", "Teasdale's", and "Towle's". It can be seen from the illustrations that the authenticity of these rival brands was hotly contested. Another version, Shinyaku (lit.
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content also made it very addictive, and deaths from overdoses, either accidental or deliberate, became a frequent occurrence. A common feature of the coroner's report in such cases would be the description of the deceased's body being found in a flat or
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Browne's
Mixture" for the relief of coughs and diarrhea. This modern formulation contains morphine and peppermint oil. The active ingredients per 5ml are: morphine hydrochloride equivalent to 1.0mg anhydrous morphine, peppermint oil 1.5 microlitres.
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Chlorodyne sold extremely well for many years; as its active ingredients were well known, local chemists' shops would also make up cheaper generic versions for sale to their customers. Here is an example of such a generic formulation, from
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repeated inclusion of advertisement for
Chlorodyne from Dr. Browne in a previous issue. Furthermore scepticism of its usefulness over other opioids and a general distaste for its Homeopathic advertisement is a consistent theme.
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50 and enough alcohol (90 per cent) to make 1000. Strength. 1 millilitre contains chloroform 7.5 centimils; morphine hydrochloride 1 centigram; acidum hydrocyanicum dilutum 5 centimils.
258:"divine-medicine"), was developed in Japan and sold domestically for many years, although its most toxic ingredients were replaced over time for reasons of safety and legality.
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Chlorodyne medicine bottles and chlorodyne lozenge tins showing various brands from the UK and
Australia
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intended to be an imitation of the proprietary medicine called chlorodyne. Mix
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solution (E420), treacle (containing sucrose and fructose), purified water.
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sold in the
British Isles. It was invented in the 19th century by a Dr.
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2 and glycerin 250 with alcohol (20 per cent) 450. Dissolve
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Parker, R. R.; Cobb, J. P.; Connell, P. H. (March 1974).
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185:, etc. As its principal ingredients were a mixture of
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Though the drug was effective in many ways, its high
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1891 advertisement for J. Collis Browne's
Chlorodyne
246:hydrochloride 10 in the mixture. Add to it diluted
46:. Unsourced material may be challenged and removed.
138:1891 advertisement for a rival brand of Chlorodyne
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165:, who advertised it widely, as a treatment for
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218:& A.H. Douthwaite, 21st edition (1932):
161:. Browne sold his formula to the pharmacist
224:Tinctura Chloroformi et Morphinæ Composita
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106:Learn how and when to remove this message
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262:Criticism from the medical community
44:adding citations to reliable sources
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373:"Professional Testimonial-Mongers"
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253:Dose 5 to 15 minims - 0.2 to 1ml
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493:The British Medical Journal
454:The British Medical Journal
448:Prichard, Augustin (1862).
415:The British Medical Journal
377:The British Medical Journal
288:The other ingredients are:
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189:(an alcoholic solution of
163:John Thistlewood Davenport
145:was one of the best known
487:Lankester, Edwin (1862).
528:"Chlorodyne dependence"
337:Ohashi, K. (1999). "".
236:tincture of Indian hemp
544:10.1136/bmj.1.5905.427
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383:(42): 415–417. 1861.
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40:improve this article
155:British Indian Army
339:Yakushigaku Zasshi
216:William Hale-White
153:, a doctor in the
151:John Collis Browne
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240:oil of peppermint
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421:(154). 1859.
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96:December 2009
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51:Find sources:
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29:This article
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489:"Chlorodyne"
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450:"Chlorodyne"
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345:(2): 89–96.
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314:hypromellose
294:benzoic acid
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55:"Chlorodyne"
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38:Please help
33:verification
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499:(74): 588.
310:citric acid
292:(alcohol),
582:Analgesics
576:Categories
324:References
300:tincture,
228:chloroform
205:Imitations
199:chloroform
143:Chlorodyne
66:newspapers
505:0007-1447
466:0007-1447
427:0007-1447
389:0007-1447
351:0285-2314
183:migraines
179:neuralgia
532:Br Med J
513:25198848
474:25198825
435:25195610
397:25198149
359:11624349
318:sorbitol
312:(E330),
298:capsicum
296:(E210),
244:morphine
232:capsicum
195:cannabis
187:laudanum
175:insomnia
171:diarrhea
562:4816855
553:1633222
306:menthol
290:ethanol
271:Decline
167:cholera
159:cholera
80:scholar
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282:bedsit
277:opiate
197:, and
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509:JSTOR
470:JSTOR
431:JSTOR
393:JSTOR
238:100,
191:opium
87:JSTOR
73:books
558:PMID
501:ISSN
462:ISSN
423:ISSN
385:ISSN
355:PMID
347:ISSN
234:25,
59:news
548:PMC
540:doi
214:by
42:by
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