1268:
449:
Prydz K, Kase BF, Björkhem I, Pedersen JI (August 1988). "Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver".
344:
317:
163:
559:
Wheeler JB, Shaw DR, Barnes S (December 1997). "Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes".
670:
182:
851:
822:
696:
735:
927:
175:
875:
142:
841:
663:
987:
942:
947:
937:
831:
520:"The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase"
136:
118:
1143:
954:
780:
656:
410:"The breakdown of adenosine triphosphate accompanying cholic acid activation by guinea-pig liver microsomes"
123:
477:
Schepers L, Casteels M, Verheyden K, Parmentier G, Asselberghs S, Eyssen HJ, Mannaerts GP (January 1989).
329:
302:
187:
1258:
922:
917:
890:
800:
775:
760:
720:
111:
1244:
1231:
1218:
1205:
1192:
1179:
1166:
1128:
912:
836:
795:
755:
745:
740:
725:
705:
46:
479:"Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver"
1138:
1092:
1035:
805:
730:
715:
687:
642:
203:
29:
139:
1040:
785:
765:
750:
710:
63:
638:
902:
810:
790:
770:
1061:
980:
932:
648:
1133:
860:
99:
8:
1097:
41:
75:
1030:
495:
478:
426:
409:
385:
368:
206:
34:
536:
519:
1288:
617:
576:
541:
500:
459:
431:
390:
289:
130:
1076:
1071:
1045:
973:
865:
607:
568:
531:
490:
421:
380:
1123:
1107:
1020:
346:
AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
278:
1272:
1161:
1102:
907:
612:
595:
594:
Falany CN, Xie X, Wheeler JB, Wang J, Smith M, He D, Barnes S (December 2002).
326:(2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA
158:
1282:
1066:
1025:
263:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
1015:
621:
572:
435:
394:
580:
545:
504:
463:
1239:
1174:
1010:
320:
243:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase
87:
369:"The enzymic activation of cholic acid by guinea-pig-liver microsomes"
1213:
1187:
285:
596:"Molecular cloning and expression of rat liver bile acid CoA ligase"
1267:
476:
251:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase
296:
106:
1226:
996:
870:
683:
679:
274:
247:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase
170:
82:
70:
58:
678:
259:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase
1200:
880:
895:
885:
94:
965:
448:
1256:
332:
305:
593:
517:
338:
311:
558:
1280:
518:Mallonee DH, Adams JL, Hylemon PB (April 1992).
981:
664:
988:
974:
671:
657:
641:at the U.S. National Library of Medicine
611:
535:
494:
425:
384:
561:Archives of Biochemistry and Biophysics
407:
366:
1281:
350:This enzyme requires Mg for activity.
969:
736:D-alanine—poly(phosphoribitol) ligase
652:
271:trihydroxycoprostanoyl-CoA synthetase
339:{\displaystyle \rightleftharpoons }
312:{\displaystyle \rightleftharpoons }
13:
876:Von Hippel–Lindau tumor suppressor
14:
1300:
632:
1266:
842:Long-chain-fatty-acid—CoA ligase
282:cholate:CoA ligase (AMP-forming)
938:Carbamoyl phosphate synthetase
832:Succinyl coenzyme A synthetase
587:
552:
511:
470:
442:
401:
360:
333:
306:
1:
353:
227:choloyl coenzyme A synthetase
408:Elliott WH (February 1957).
7:
995:
219:bile acid coenzyme A ligase
10:
1305:
923:Holocarboxylase synthetase
918:Argininosuccinate synthase
891:Anaphase-promoting complex
613:10.1194/jlr.M200260-JLR200
1152:
1144:Michaelis–Menten kinetics
1116:
1085:
1054:
1003:
955:Glutamate–cysteine ligase
913:Adenylosuccinate synthase
850:
821:
706:Aminoacyl tRNA synthetase
695:
600:Journal of Lipid Research
452:Journal of Lipid Research
367:Elliott WH (March 1956).
181:
169:
157:
152:
148:
129:
117:
105:
93:
81:
69:
57:
52:
40:
28:
23:
18:
1036:Diffusion-limited enzyme
643:Medical Subject Headings
524:Journal of Bacteriology
483:The Biochemical Journal
414:The Biochemical Journal
373:The Biochemical Journal
903:Glutathione synthetase
573:10.1006/abbi.1997.0391
340:
313:
239:cholic acid:CoA ligase
223:choloyl-CoA synthetase
1129:Eadie–Hofstee diagram
1062:Allosteric regulation
933:Asparagine synthetase
837:Acetyl—CoA synthetase
341:
314:
267:cholyl-CoA synthetase
1139:Lineweaver–Burk plot
861:Glutamine synthetase
639:Cholate---CoA+ligase
330:
303:
215:bile acid CoA ligase
1098:Enzyme superfamily
1031:Enzyme promiscuity
336:
309:
235:cholate thiokinase
200:Cholate—CoA ligase
19:Cholate—CoA ligase
1254:
1253:
963:
962:
854:: Carbon-Nitrogen
290:chemical reaction
231:cholic thiokinase
197:
196:
193:
192:
112:metabolic pathway
1296:
1271:
1270:
1262:
1134:Hanes–Woolf plot
1077:Enzyme activator
1072:Enzyme inhibitor
1046:Enzyme catalysis
990:
983:
976:
967:
966:
866:Ubiquitin ligase
673:
666:
659:
650:
649:
626:
625:
615:
591:
585:
584:
556:
550:
549:
539:
515:
509:
508:
498:
474:
468:
467:
446:
440:
439:
429:
405:
399:
398:
388:
364:
345:
343:
342:
337:
318:
316:
315:
310:
150:
149:
16:
15:
1304:
1303:
1299:
1298:
1297:
1295:
1294:
1293:
1279:
1278:
1277:
1265:
1257:
1255:
1250:
1162:Oxidoreductases
1148:
1124:Enzyme kinetics
1112:
1108:List of enzymes
1081:
1050:
1021:Catalytic triad
999:
994:
964:
959:
846:
825:: Carbon-Sulfur
817:
699:: Carbon-Oxygen
691:
682:: CO CS and CN
677:
635:
630:
629:
606:(12): 2062–71.
592:
588:
557:
553:
516:
512:
475:
471:
458:(8): 997–1004.
447:
443:
406:
402:
365:
361:
356:
331:
328:
327:
304:
301:
300:
279:systematic name
255:THCA-CoA ligase
12:
11:
5:
1302:
1292:
1291:
1276:
1275:
1252:
1251:
1249:
1248:
1235:
1222:
1209:
1196:
1183:
1170:
1156:
1154:
1150:
1149:
1147:
1146:
1141:
1136:
1131:
1126:
1120:
1118:
1114:
1113:
1111:
1110:
1105:
1100:
1095:
1089:
1087:
1086:Classification
1083:
1082:
1080:
1079:
1074:
1069:
1064:
1058:
1056:
1052:
1051:
1049:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1007:
1005:
1001:
1000:
993:
992:
985:
978:
970:
961:
960:
958:
957:
952:
951:
950:
945:
935:
930:
925:
920:
915:
910:
908:CTP synthetase
905:
900:
899:
898:
893:
888:
883:
878:
873:
863:
857:
855:
848:
847:
845:
844:
839:
834:
828:
826:
819:
818:
816:
815:
814:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
702:
700:
693:
692:
676:
675:
668:
661:
653:
647:
646:
634:
633:External links
631:
628:
627:
586:
551:
530:(7): 2065–71.
510:
469:
441:
400:
358:
357:
355:
352:
348:
347:
335:
324:
308:
288:the following
284:. This enzyme
195:
194:
191:
190:
185:
179:
178:
173:
167:
166:
161:
155:
154:
146:
145:
134:
127:
126:
121:
115:
114:
109:
103:
102:
97:
91:
90:
85:
79:
78:
73:
67:
66:
61:
55:
54:
50:
49:
44:
38:
37:
32:
26:
25:
21:
20:
9:
6:
4:
3:
2:
1301:
1290:
1287:
1286:
1284:
1274:
1269:
1264:
1263:
1260:
1246:
1242:
1241:
1236:
1233:
1229:
1228:
1223:
1220:
1216:
1215:
1210:
1207:
1203:
1202:
1197:
1194:
1190:
1189:
1184:
1181:
1177:
1176:
1171:
1168:
1164:
1163:
1158:
1157:
1155:
1151:
1145:
1142:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1121:
1119:
1115:
1109:
1106:
1104:
1103:Enzyme family
1101:
1099:
1096:
1094:
1091:
1090:
1088:
1084:
1078:
1075:
1073:
1070:
1068:
1067:Cooperativity
1065:
1063:
1060:
1059:
1057:
1053:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1026:Oxyanion hole
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1008:
1006:
1002:
998:
991:
986:
984:
979:
977:
972:
971:
968:
956:
953:
949:
946:
944:
941:
940:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
868:
867:
864:
862:
859:
858:
856:
853:
849:
843:
840:
838:
835:
833:
830:
829:
827:
824:
820:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
781:Phenylalanine
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
708:
707:
704:
703:
701:
698:
694:
689:
685:
681:
674:
669:
667:
662:
660:
655:
654:
651:
644:
640:
637:
636:
623:
619:
614:
609:
605:
601:
597:
590:
582:
578:
574:
570:
566:
562:
555:
547:
543:
538:
533:
529:
525:
521:
514:
506:
502:
497:
492:
488:
484:
480:
473:
465:
461:
457:
453:
445:
437:
433:
428:
423:
420:(2): 315–21.
419:
415:
411:
404:
396:
392:
387:
382:
379:(3): 427–33.
378:
374:
370:
363:
359:
351:
325:
323:+ choloyl-CoA
322:
298:
294:
293:
292:
291:
287:
283:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
205:
201:
189:
186:
184:
180:
177:
174:
172:
168:
165:
162:
160:
156:
151:
147:
144:
141:
138:
135:
132:
128:
125:
122:
120:
116:
113:
110:
108:
104:
101:
98:
96:
92:
89:
88:NiceZyme view
86:
84:
80:
77:
74:
72:
68:
65:
62:
60:
56:
51:
48:
45:
43:
39:
36:
33:
31:
27:
22:
17:
1240:Translocases
1237:
1224:
1211:
1198:
1185:
1175:Transferases
1172:
1159:
1016:Binding site
928:GMP synthase
603:
599:
589:
567:(1): 15–24.
564:
560:
554:
527:
523:
513:
489:(1): 221–9.
486:
482:
472:
455:
451:
444:
417:
413:
403:
376:
372:
362:
349:
281:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
199:
198:
76:BRENDA entry
1011:Active site
321:diphosphate
64:IntEnz view
24:Identifiers
1214:Isomerases
1188:Hydrolases
1055:Regulation
801:Tryptophan
776:Methionine
761:Isoleucine
721:Asparagine
354:References
295:(1) ATP +
133:structures
100:KEGG entry
47:9027-90-1
1093:EC number
796:Threonine
756:Histidine
746:Glutamine
741:Glutamate
726:Aspartate
334:⇌
307:⇌
286:catalyses
53:Databases
1289:EC 6.2.1
1283:Category
1117:Kinetics
1041:Cofactor
1004:Activity
806:Tyrosine
731:Cysteine
716:Arginine
690:6.1-6.3)
622:12454267
436:13403911
395:13303991
273:) is an
188:proteins
176:articles
164:articles
137:RCSB PDB
1273:Biology
1227:Ligases
997:Enzymes
786:Proline
766:Leucine
751:Glycine
711:Alanine
684:ligases
680:Enzymes
581:9390170
546:1551828
505:2521999
496:1135559
464:3183523
427:1199872
386:1215932
297:cholate
207:6.2.1.7
124:profile
107:MetaCyc
42:CAS no.
35:6.2.1.7
1259:Portal
1201:Lyases
871:Cullin
811:Valine
791:Serine
771:Lysine
645:(MeSH)
620:
579:
544:
537:205821
534:
503:
493:
462:
434:
424:
393:
383:
319:AMP +
299:+ CoA
275:enzyme
171:PubMed
153:Search
143:PDBsum
83:ExPASy
71:BRENDA
59:IntEnz
30:EC no.
1153:Types
881:UBE3A
277:with
119:PRIAM
1245:list
1238:EC7
1232:list
1225:EC6
1219:list
1212:EC5
1206:list
1199:EC4
1193:list
1186:EC3
1180:list
1173:EC2
1167:list
1160:EC1
896:UBR1
886:Mdm2
618:PMID
577:PMID
542:PMID
501:PMID
460:PMID
432:PMID
391:PMID
183:NCBI
140:PDBe
95:KEGG
852:6.3
823:6.2
697:6.1
608:doi
569:doi
565:348
532:PMC
528:174
491:PMC
487:257
422:PMC
381:PMC
211:BAL
159:PMC
131:PDB
1285::
948:II
688:EC
616:.
604:43
602:.
598:.
575:.
563:.
540:.
526:.
522:.
499:.
485:.
481:.
456:29
454:.
430:.
418:65
416:.
412:.
389:.
377:62
375:.
371:.
269:,
265:,
261:,
257:,
253:,
249:,
245:,
241:,
237:,
233:,
229:,
225:,
221:,
217:,
213:,
209:,
204:EC
1261::
1247:)
1243:(
1234:)
1230:(
1221:)
1217:(
1208:)
1204:(
1195:)
1191:(
1182:)
1178:(
1169:)
1165:(
989:e
982:t
975:v
943:I
686:(
672:e
665:t
658:v
624:.
610::
583:.
571::
548:.
507:.
466:.
438:.
397:.
202:(
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