66:
2371:
2401:
2411:
2391:
2381:
40:
202:
If someone has coagulopathy, their health care provider may help them manage their symptoms with medications or replacement therapy. In replacement therapy, the reduced or absent clotting factors are replaced with proteins derived from human blood or created in the laboratory. This therapy may be
113:
Coagulopathy may cause uncontrolled internal or external bleeding. Left untreated, uncontrolled bleeding may cause damage to joints, muscles, or internal organs and may be life-threatening. People should seek immediate medical care for serious symptoms, including heavy external bleeding,
245:
is the only option that is currently supported by a large, randomized, controlled clinical trial, and is given to people with major bleeding after trauma. There are several possible risks to treating coagulopathies, such as transfusion-related
211:
One area of treatment is managing people with major bleeding in a critical setting, like an emergency department. In these situations, the common treatment is transfusing a combination of red cells with one of the following options:
138:
The normal clotting process depends on the interplay of various proteins in the blood. Coagulopathy may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation factors.
926:
907:
130:, difficulty walking, convulsions, or seizures. They should seek prompt medical care if they experience mild but unstoppable external bleeding or joint swelling and stiffness.
97:
Coagulopathies are sometimes erroneously referred to as "clotting disorders", but a clotting disorder is the opposite, defined as a predisposition to excessive clot formation (
991:
984:
1900:
2241:
977:
1840:
1108:
327:
181:, first introduced the term Acute Traumatic Coagulopathy (ATC), establishing that coagulopathy induced by trauma results in:
2140:
161:
will also prevent clots from forming properly. Coagulopathy may also occur as a result of dysfunction or reduced levels of
1283:
1266:
255:
251:
2276:
1618:
1345:
1297:
178:
2394:
2266:
1700:
1064:
1351:
1337:
586:
2246:
1325:
1288:
1158:
607:
1890:
1478:
1054:
283:
1870:
1433:
1278:
510:
750:
Spahn DR, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, et al. (April 2013).
2299:
1549:
1120:
1101:
2091:
2013:
2008:
1928:
1688:
1519:
1262:
1091:
941:
65:
2440:
2071:
2045:
1509:
1302:
1663:
1611:
1423:
1398:
1356:
752:"Management of bleeding and coagulopathy following major trauma: an updated European guideline"
354:
263:
148:
2314:
2200:
2173:
2146:
2098:
2052:
1747:
1418:
1408:
1226:
679:
651:
203:
given either to treat bleeding that has already begun or to prevent bleeding from occurring.
2334:
2294:
2161:
1975:
1970:
1950:
1885:
1737:
1174:
1069:
1059:
300:
90:) is impaired. This condition can cause a tendency toward prolonged or excessive bleeding (
94:), which may occur spontaneously or following an injury or medical and dental procedures.
8:
2414:
2356:
2339:
1998:
1715:
1413:
1403:
1199:
1079:
930:
188:
2304:
2261:
2251:
2040:
1993:
1960:
1955:
1705:
1683:
1539:
1221:
1179:
1153:
1026:
875:
832:
778:
751:
689:
115:
91:
863:
819:
802:
2435:
2400:
2374:
2256:
2226:
2205:
2168:
2151:
2066:
2030:
2020:
1915:
1835:
1779:
1742:
1727:
1668:
1635:
1604:
1428:
1204:
1113:
969:
952:
867:
824:
783:
729:
684:
630:
247:
140:
54:
935:
879:
850:
Shakur H, Roberts I, Perel P (2010). "Tranexamic acid for trauma – Authors' reply".
2384:
2076:
2061:
1938:
1813:
1769:
1254:
1194:
1189:
1049:
859:
836:
814:
773:
763:
721:
419:
278:
2404:
2349:
2210:
2195:
2178:
2118:
2113:
2057:
2035:
1732:
1678:
1658:
1534:
1368:
1209:
1074:
946:
563:
242:
235:
165:(small disk-shaped bodies in the bloodstream that aid in the clotting process).
2236:
2190:
2003:
1933:
1752:
1559:
1271:
1214:
1096:
957:
293:
154:
119:
2429:
2319:
2108:
2103:
1965:
1905:
1808:
1569:
1391:
1386:
1381:
1138:
871:
442:
288:
123:
102:
1312:
920:
916:
2324:
2309:
2135:
1860:
1710:
1695:
1641:
1579:
828:
787:
733:
216:
174:
725:
2183:
2128:
2025:
1880:
1855:
1673:
1376:
1184:
1016:
1005:
712:
Hunt BJ (February 2014). "Bleeding and coagulopathies in critical care".
225:
221:
83:
2271:
2156:
2123:
1895:
1845:
1830:
1825:
1818:
1803:
1793:
1564:
1529:
1504:
1148:
1130:
377:
259:
229:
144:
59:
899:
2344:
2086:
2081:
1945:
1923:
1798:
1762:
1554:
1499:
1086:
47:
768:
1850:
1627:
1468:
1463:
1453:
1143:
1001:
559:
535:
304:
162:
158:
127:
98:
87:
270:
Laboratory findings in various platelet and coagulation disorders
2329:
1789:
1757:
1650:
1514:
1473:
398:
1458:
911:
489:
39:
1596:
749:
999:
889:
800:
16:
Condition involving impaired blood clotting ability
849:
82:) is a condition in which the blood's ability to
2427:
843:
801:Brohi K, Singh J, Heron M, Coats T (June 2003).
168:
1612:
985:
151:, can cause a reduction in clotting factors.
101:), also known as a hypercoagulable state or
1901:Reproductive endocrinology and infertility
1619:
1605:
992:
978:
707:
705:
64:
38:
2242:Bachelor of Medicine, Bachelor of Surgery
818:
777:
767:
745:
743:
1246:
702:
2428:
328:Disseminated intravascular coagulation
1600:
973:
740:
126:, severe head or neck pain, repeated
108:
2380:
2141:Physical medicine and rehabilitation
711:
2390:
714:The New England Journal of Medicine
256:multiple organ dysfunction syndrome
252:acute respiratory distress syndrome
173:In 2003, Karim Brohi, Professor of
13:
2277:Medical Scientist Training Program
14:
2452:
820:10.1097/01.TA.0000069184.82147.06
2409:
2399:
2389:
2379:
2370:
2369:
1346:platelet storage pool deficiency
1298:Heparin-induced thrombocytopenia
206:
2410:
179:Queen Mary University of London
2267:Doctor of Osteopathic Medicine
1701:Oral and maxillofacial surgery
1065:Activated protein C resistance
803:"Acute traumatic coagulopathy"
794:
1:
864:10.1016/S0140-6736(10)61479-1
695:
2247:Bachelor of Medical Sciences
2014:Neurosurgical anesthesiology
1626:
1159:Trousseau sign of malignancy
197:
169:Acute traumatic coagulopathy
133:
7:
1479:Nonthrombocytopenic purpura
1055:Antithrombin III deficiency
673:
284:Partial thromboplastin time
10:
2457:
1434:Congenital afibrinogenemia
1338:Glanzmann's thrombasthenia
587:Glanzmann's thrombasthenia
511:Congenital afibrinogenemia
315:Normal or mildly prolonged
2365:
2287:
2225:
1986:
1914:
1869:
1778:
1649:
1634:
1550:Gastrointestinal bleeding
1489:
1446:
1367:
1352:Hermansky–Pudlak syndrome
1311:
1253:
1239:
1167:
1129:
1121:Antiphospholipid syndrome
1102:Essential thrombocythemia
1042:
1035:
1012:
893:
464:Liver failure, end-stage
53:
46:
37:
29:
24:
2201:Transplantation medicine
2092:Clinical neurophysiology
2009:Obstetric anesthesiology
1929:Interventional radiology
1689:Digestive system surgery
1520:Subconjunctival bleeding
1326:Bernard–Soulier syndrome
1289:Upshaw–Schulman syndrome
1263:Thrombocytopenic purpura
1092:Sticky platelet syndrome
608:Bernard–Soulier syndrome
2072:Intensive care medicine
2046:Mass gathering medicine
1891:Maternal–fetal medicine
1510:Intracranial hemorrhage
624:Decreased or unaffected
363:Prolonged or unaffected
1664:Cardiothoracic surgery
1424:Factor XIII deficiency
1404:Hypoprothrombinemia/II
1399:von Willebrand disease
1357:Gray platelet syndrome
562:deficiency as seen in
355:Von Willebrand disease
264:venous thromboembolism
149:Von Willebrand disease
2315:Personalized medicine
2174:Reproductive medicine
2099:Occupational medicine
2053:Evolutionary medicine
1419:Factor XII deficiency
1409:Factor VII deficiency
1227:Renal vein thrombosis
807:The Journal of Trauma
726:10.1056/NEJMra1208626
680:Trauma triad of death
224:complex concentrate,
2335:Traditional medicine
2295:Alternative medicine
2162:Addiction psychiatry
1976:Transfusion medicine
1971:Medical microbiology
1886:Gynecologic oncology
1738:Reproductive surgery
1175:Deep vein thrombosis
1070:Protein S deficiency
1060:Protein C deficiency
631:Factor XI deficiency
301:Vitamin K deficiency
185:more severe bleeding
2357:History of medicine
2340:Veterinary medicine
2147:Preventive medicine
1999:Adolescent medicine
1841:Infectious diseases
1414:Factor X deficiency
1303:May–Hegglin anomaly
1080:Prothrombin G20210A
858:(9746): 1050–1051.
271:
189:multi-organ failure
2305:Molecular oncology
2262:Doctor of Medicine
2252:Master of Medicine
2169:Radiation oncology
2041:Emergency medicine
1994:Addiction medicine
1961:Clinical chemistry
1956:Clinical pathology
1748:Transplant surgery
1706:Orthopedic surgery
1684:Colorectal surgery
1540:Pulmonary hematoma
1447:Signs and symptoms
1222:Pulmonary embolism
1027:Bleeding diathesis
690:Hypercoagulability
269:
116:blood in the urine
109:Signs and symptoms
92:bleeding diathesis
2423:
2422:
2257:Master of Surgery
2221:
2220:
2206:Tropical medicine
2152:Prison healthcare
2067:Hospital medicine
2031:Disaster medicine
2021:Aviation medicine
1836:Hospital medicine
1743:Surgical oncology
1728:Pediatric surgery
1722:
1669:Endocrine surgery
1594:
1593:
1590:
1589:
1442:
1441:
1429:Dysfibrinogenemia
1313:Platelet function
1235:
1234:
1114:Purpura fulminans
967:
966:
685:Hypocoagulability
671:
670:
248:acute lung injury
141:Genetic disorders
80:bleeding disorder
73:
72:
33:Bleeding disorder
19:Medical condition
2448:
2413:
2412:
2403:
2393:
2392:
2383:
2382:
2373:
2372:
2077:Medical genetics
2062:General practice
1939:Nuclear medicine
1814:Gastroenterology
1770:Vascular surgery
1720:
1647:
1646:
1621:
1614:
1607:
1598:
1597:
1255:Thrombocytopenia
1251:
1250:
1244:
1243:
1200:Lowenberg's sign
1050:Clotting factors
1040:
1039:
994:
987:
980:
971:
970:
891:
890:
884:
883:
847:
841:
840:
822:
813:(6): 1127–1130.
798:
792:
791:
781:
771:
747:
738:
737:
709:
652:C1INH deficiency
420:Thrombocytopenia
279:Prothrombin time
272:
268:
234:Fibrinogen with
69:
68:
42:
22:
21:
2456:
2455:
2451:
2450:
2449:
2447:
2446:
2445:
2426:
2425:
2424:
2419:
2361:
2350:Chief physician
2283:
2228:
2217:
2211:Travel medicine
2196:Sports medicine
2179:Sexual medicine
2119:Palliative care
2114:Pain management
2058:Family medicine
2036:Diving medicine
1982:
1910:
1872:
1865:
1781:
1774:
1733:Plastic surgery
1679:General surgery
1659:Cardiac surgery
1640:
1638:
1630:
1625:
1595:
1586:
1535:Hemopericardium
1485:
1438:
1369:Clotting factor
1363:
1307:
1231:
1180:Bancroft's sign
1163:
1154:Virchow's triad
1125:
1075:Factor V Leiden
1031:
1008:
998:
968:
963:
962:
902:
888:
887:
848:
844:
799:
795:
769:10.1186/cc12685
748:
741:
710:
703:
698:
676:
564:amyloid purpura
243:tranexamic acid
236:tranexamic acid
209:
200:
175:Trauma Sciences
171:
136:
111:
78:(also called a
63:
20:
17:
12:
11:
5:
2454:
2444:
2443:
2441:Coagulopathies
2438:
2421:
2420:
2418:
2417:
2407:
2397:
2387:
2377:
2366:
2363:
2362:
2360:
2359:
2354:
2353:
2352:
2342:
2337:
2332:
2327:
2322:
2317:
2312:
2307:
2302:
2297:
2291:
2289:
2288:Related topics
2285:
2284:
2282:
2281:
2280:
2279:
2269:
2264:
2259:
2254:
2249:
2244:
2239:
2237:Medical school
2233:
2231:
2223:
2222:
2219:
2218:
2216:
2215:
2214:
2213:
2203:
2198:
2193:
2191:Sleep medicine
2188:
2187:
2186:
2176:
2171:
2166:
2165:
2164:
2154:
2149:
2144:
2138:
2133:
2132:
2131:
2121:
2116:
2111:
2106:
2101:
2096:
2095:
2094:
2084:
2079:
2074:
2069:
2064:
2055:
2050:
2049:
2048:
2038:
2033:
2028:
2023:
2018:
2017:
2016:
2011:
2004:Anesthesiology
2001:
1996:
1990:
1988:
1984:
1983:
1981:
1980:
1979:
1978:
1973:
1968:
1963:
1958:
1953:
1943:
1942:
1941:
1936:
1934:Neuroradiology
1931:
1920:
1918:
1912:
1911:
1909:
1908:
1903:
1898:
1893:
1888:
1883:
1877:
1875:
1871:Obstetrics and
1867:
1866:
1864:
1863:
1858:
1853:
1848:
1843:
1838:
1833:
1828:
1823:
1822:
1821:
1811:
1806:
1801:
1796:
1786:
1784:
1776:
1775:
1773:
1772:
1767:
1766:
1765:
1755:
1753:Trauma surgery
1750:
1745:
1740:
1735:
1730:
1725:
1724:
1723:
1716:Otolaryngology
1713:
1708:
1703:
1698:
1693:
1692:
1691:
1686:
1676:
1671:
1666:
1661:
1655:
1653:
1644:
1642:subspecialties
1632:
1631:
1624:
1623:
1616:
1609:
1601:
1592:
1591:
1588:
1587:
1585:
1584:
1583:
1582:
1574:
1573:
1572:
1567:
1562:
1560:Hemoperitoneum
1557:
1552:
1544:
1543:
1542:
1537:
1532:
1524:
1523:
1522:
1517:
1512:
1507:
1502:
1493:
1491:
1487:
1486:
1484:
1483:
1482:
1481:
1471:
1466:
1461:
1456:
1450:
1448:
1444:
1443:
1440:
1439:
1437:
1436:
1431:
1426:
1421:
1416:
1411:
1406:
1401:
1396:
1395:
1394:
1389:
1384:
1373:
1371:
1365:
1364:
1362:
1361:
1360:
1359:
1354:
1342:
1341:
1340:
1330:
1329:
1328:
1317:
1315:
1309:
1308:
1306:
1305:
1300:
1294:
1293:
1292:
1291:
1286:
1276:
1275:
1274:
1272:Evans syndrome
1259:
1257:
1248:
1241:
1237:
1236:
1233:
1232:
1230:
1229:
1224:
1219:
1218:
1217:
1212:
1207:
1205:Peabody's sign
1202:
1197:
1192:
1187:
1182:
1171:
1169:
1165:
1164:
1162:
1161:
1156:
1151:
1146:
1141:
1135:
1133:
1127:
1126:
1124:
1123:
1118:
1117:
1116:
1106:
1105:
1104:
1099:
1097:Thrombocytosis
1094:
1084:
1083:
1082:
1077:
1072:
1067:
1062:
1057:
1046:
1044:
1037:
1033:
1032:
1030:
1029:
1024:
1019:
1013:
1010:
1009:
997:
996:
989:
982:
974:
965:
964:
961:
960:
949:
938:
923:
903:
898:
897:
895:
894:Classification
886:
885:
842:
793:
739:
720:(9): 847–859.
700:
699:
697:
694:
693:
692:
687:
682:
675:
672:
669:
668:
665:
662:
657:
654:
648:
647:
644:
641:
636:
633:
627:
626:
621:
616:
613:
610:
604:
603:
600:
595:
592:
589:
583:
582:
579:
576:
571:
566:
556:
555:
552:
549:
544:
539:
532:
531:
528:
523:
518:
513:
507:
506:
503:
498:
495:
492:
486:
485:
480:
475:
470:
465:
461:
460:
457:
454:
451:
446:
439:
438:
433:
428:
425:
422:
416:
415:
412:
407:
404:
401:
395:
394:
391:
388:
383:
380:
374:
373:
370:
365:
360:
357:
351:
350:
345:
340:
335:
330:
324:
323:
320:
317:
312:
307:
297:
296:
294:Platelet count
291:
286:
281:
276:
239:
238:
232:
219:
208:
205:
199:
196:
195:
194:
193:high mortality
191:
186:
170:
167:
155:Anticoagulants
135:
132:
110:
107:
71:
70:
57:
51:
50:
44:
43:
35:
34:
31:
27:
26:
18:
15:
9:
6:
4:
3:
2:
2453:
2442:
2439:
2437:
2434:
2433:
2431:
2416:
2408:
2406:
2402:
2398:
2396:
2388:
2386:
2378:
2376:
2368:
2367:
2364:
2358:
2355:
2351:
2348:
2347:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2320:Public health
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2300:Allied health
2298:
2296:
2293:
2292:
2290:
2286:
2278:
2275:
2274:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2234:
2232:
2230:
2224:
2212:
2209:
2208:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2185:
2182:
2181:
2180:
2177:
2175:
2172:
2170:
2167:
2163:
2160:
2159:
2158:
2155:
2153:
2150:
2148:
2145:
2142:
2139:
2137:
2134:
2130:
2127:
2126:
2125:
2122:
2120:
2117:
2115:
2112:
2110:
2109:Oral medicine
2107:
2105:
2104:Ophthalmology
2102:
2100:
2097:
2093:
2090:
2089:
2088:
2085:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2059:
2056:
2054:
2051:
2047:
2044:
2043:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2015:
2012:
2010:
2007:
2006:
2005:
2002:
2000:
1997:
1995:
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1991:
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1966:Cytopathology
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1932:
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1913:
1907:
1906:Urogynecology
1904:
1902:
1899:
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1834:
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1810:
1809:Endocrinology
1807:
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1617:
1615:
1610:
1608:
1603:
1602:
1599:
1581:
1578:
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1571:
1570:Hematosalpinx
1568:
1566:
1563:
1561:
1558:
1556:
1553:
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1545:
1541:
1538:
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1412:
1410:
1407:
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1397:
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1374:
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1223:
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1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1195:Louvel's sign
1193:
1191:
1190:Lisker's sign
1188:
1186:
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1177:
1176:
1173:
1172:
1170:
1166:
1160:
1157:
1155:
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1150:
1147:
1145:
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1140:
1139:Thrombophilia
1137:
1136:
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1128:
1122:
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1038:
1034:
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1007:
1003:
1000:Disorders of
995:
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983:
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948:
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834:
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826:
821:
816:
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808:
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797:
789:
785:
780:
775:
770:
765:
761:
757:
756:Critical Care
753:
746:
744:
735:
731:
727:
723:
719:
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708:
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691:
688:
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469:
466:
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458:
455:
452:
450:
447:
444:
443:Liver failure
441:
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437:
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429:
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402:
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326:
325:
321:
318:
316:
313:
311:
308:
306:
302:
299:
298:
295:
292:
290:
289:Bleeding time
287:
285:
282:
280:
277:
274:
273:
267:
265:
261:
257:
253:
249:
244:
237:
233:
231:
227:
223:
220:
218:
215:
214:
213:
207:Critical care
204:
192:
190:
187:
184:
183:
182:
180:
176:
166:
164:
160:
156:
152:
150:
146:
142:
131:
129:
125:
124:double vision
121:
117:
106:
104:
103:thrombophilia
100:
95:
93:
89:
85:
81:
77:
67:
61:
58:
56:
52:
49:
45:
41:
36:
32:
28:
23:
2325:Rural health
2310:Nanomedicine
1861:Rheumatology
1792: /
1711:Hand surgery
1696:Neurosurgery
1580:Hemarthrosis
1344:
1332:
1320:
1210:Pratt's sign
1022:coagulopathy
1021:
951:
940:
925:
906:
855:
851:
845:
810:
806:
796:
759:
755:
717:
713:
659:
638:
623:
618:
597:
573:
568:
546:
541:
525:
520:
515:
500:
482:
477:
472:
467:
448:
435:
430:
409:
385:
367:
362:
347:
342:
337:
332:
314:
309:
240:
217:Blood plasma
210:
201:
172:
153:
137:
112:
96:
79:
76:Coagulopathy
75:
74:
25:Coagulopathy
2395:Wikiproject
2184:Venereology
2129:Neonatology
2026:Dermatology
1881:Gynaecology
1873:gynaecology
1856:Pulmonology
1674:Eye surgery
1636:Specialties
1333:aggregation
1215:Rose's sign
1185:Homans sign
1017:Coagulation
667:Unaffected
664:Unaffected
656:Unaffected
646:Unaffected
643:Unaffected
635:Unaffected
615:Unaffected
612:Unaffected
602:Unaffected
594:Unaffected
591:Unaffected
581:Unaffected
578:Unaffected
554:Unaffected
551:Unaffected
538:deficiency
530:Unaffected
505:Unaffected
497:Unaffected
494:Unaffected
459:Unaffected
456:Unaffected
453:Unaffected
427:Unaffected
424:Unaffected
414:Unaffected
406:Unaffected
403:Unaffected
393:Unaffected
390:Unaffected
382:Unaffected
372:Unaffected
359:Unaffected
322:Unaffected
319:Unaffected
241:The use of
226:factor XIII
222:Prothrombin
30:Other names
2430:Categories
2157:Psychiatry
2143:(PM&R)
2136:Phlebology
2124:Pediatrics
1951:Anatomical
1916:Diagnostic
1896:Obstetrics
1846:Nephrology
1831:Hematology
1826:Geriatrics
1819:Hepatology
1804:Cardiology
1794:Immunology
1565:Hematocele
1530:Hemothorax
1505:Hemoptysis
1377:Hemophilia
1149:Thrombosis
953:DiseasesDB
852:The Lancet
762:(2): R76.
696:References
378:Hemophilia
275:Condition
260:hemorrhage
230:fibrinogen
145:hemophilia
143:, such as
60:Hematology
2345:Physician
2229:education
2087:Neurology
2082:Narcology
1946:Pathology
1924:Radiology
1799:Angiology
1763:Andrology
1555:Hemobilia
1500:Epistaxis
1087:Platelets
872:0140-6736
660:Shortened
639:Prolonged
619:Prolonged
598:Prolonged
574:Prolonged
569:Prolonged
547:Prolonged
542:Prolonged
526:Prolonged
521:Prolonged
516:Prolonged
501:Prolonged
483:Decreased
478:Prolonged
473:Prolonged
468:Prolonged
449:Prolonged
436:Decreased
431:Prolonged
410:Prolonged
386:Prolonged
368:Prolonged
348:Decreased
343:Prolonged
338:Prolonged
333:Prolonged
310:Prolonged
198:Treatment
163:platelets
134:Mechanism
84:coagulate
55:Specialty
48:Platelets
2436:Bleeding
2375:Category
1851:Oncology
1782:medicine
1780:Internal
1628:Medicine
1546:abdomen
1469:Petechia
1464:Hematoma
1454:Bleeding
1321:adhesion
1247:By cause
1240:Bleeding
1144:Thrombus
1043:By cause
1036:Clotting
1006:clotting
1002:bleeding
880:54321951
829:12813333
788:23601765
734:24571757
674:See also
560:Factor X
536:Factor V
445:, early
305:warfarin
258:, major
159:warfarin
157:such as
128:vomiting
99:thrombus
2415:Outline
2385:Commons
2330:Therapy
2227:Medical
1790:Allergy
1758:Urology
1651:Surgery
1515:Hyphema
1490:By site
1474:Purpura
1168:By site
947:D001778
837:7583542
779:4056078
399:Aspirin
2405:Portal
2272:MD–PhD
1576:joint
1526:torso
1459:Bruise
1382:A/VIII
878:
870:
835:
827:
786:
776:
732:
490:Uremia
262:, and
228:, and
86:(form
62:
1987:Other
1496:head
1131:Clots
958:29158
876:S2CID
833:S2CID
120:stool
88:clots
1392:C/XI
1387:B/IX
1004:and
942:MeSH
931:9-CM
868:ISSN
825:PMID
784:PMID
730:PMID
147:and
1721:ENT
1639:and
1284:TTP
1267:ITP
1109:DIC
936:286
927:ICD
921:D68
917:D65
908:ICD
860:doi
856:376
815:doi
774:PMC
764:doi
722:doi
718:370
303:or
177:at
118:or
2432::
2060:/
1279:TM
1265::
956::
945::
934::
915::
912:10
874:.
866:.
854:.
831:.
823:.
811:54
809:.
805:.
782:.
772:.
760:17
758:.
754:.
742:^
728:.
716:.
704:^
266:.
254:,
250:,
122:,
105:.
1620:e
1613:t
1606:v
993:e
986:t
979:v
929:-
919:-
910:-
900:D
882:.
862::
839:.
817::
790:.
766::
736:.
724::
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