459:. It is an ion-exchange resin, is an orally administered bile acid sequestrant that is being developed by Mitsubishi Tanabe Pharma Corporation for the treatment of hypercholesterolaemia and hyperphosphataemia. It has been launched in Japan for hypercholesterolaemia. For the treatment of hyperphosphataemia, it is launched in Austria, Germany, the Czech Republic, Portugal and the United Kingdom, is registered in the EU. Phase III development in paediatric patients with hyperphosphataemia associated with chronic kidney disease was underway in the UK and Germany. However, the company discontinued the development. In addition, the phase II development in type-2 diabetes mellitus and phase I development in hyperphosphataemia, in Japan, was also discontinued by the company.
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Phase III development for hyperphosphataemia was previously underway in the US. However, Mitsubishi Tanabe Pharma discontinued development in this market. Colestilan was also investigated in phase III trials in Europe and Asia for hypercholesterolaemia. However, as of March 2015, no recent reports of
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587:. Colestilan is not absorbed from the gut, but is excreted together with the bound anions.
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The substance can inhibit the resorption of other drugs, as well as fat soluble vitamins (
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725:(in German). Vienna: Ãsterreichischer Apothekerverlag. BindRen 1 g Filmtabletten.
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Klement A (11 November 2013). "Dialysepflichtig â weniger
Phosphat mit BindRen".
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deficiency. Vitamin K deficiency sometimes causes gastrointestinal bleeding.
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642:"Role of bile acid sequestrants in the treatment of type 2 diabetes"
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Colestilan is contraindicated in patients with bowel obstruction.
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development have been identified for the drug in this indication
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583:. It binds these anions in the gut and removes them from the
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concentrations in the blood serum) in patients undergoing
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695:. Springer Nature Switzerland AG. December 2, 2015
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598:-imidazole (left) and epichlorohydrin (right)
543:such as constipation, as well as vitamin and
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137:In general: â (Prescription only)
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1553:Magnesium pyridoxal 5-phosphate glutamate
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471:Colestilan is used for the treatment of
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828:Calcium acetate/magnesium carbonate
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13:
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209:2-(chloromethyl)oxirane 2-methyl-1
14:
1667:
917:Cholesterol absorption inhibitors
648:. 34 Suppl 2 (Suppl 2): S244-50.
551:Chemistry and mechanism of action
627:Ãsterreichische Apothekerzeitung
498:
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800:Sodium zirconium cyclosilicate
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1:
555:Colestilan is a cross-linked
7:
629:(in German) (23/2013): 28f.
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375:Chemical and physical data
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1568:Omegaâ3-acid ethyl esters
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721:Haberfeld H, ed. (2013).
689:"Drug Profile:Colestilan"
640:Handelsman Y (May 2011).
585:enterohepatic circulation
541:gastrointestinal problems
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26:
1467:Bempedoic acid/ezetimibe
1088:Niacin and derivatives (
853:Sucroferric oxyhydroxide
539:Adverse effects include
62:International Drug Names
1492:Fenofibrate/simvastatin
1487:Fenofibrate/pravastatin
1462:Amlodipine/atorvastatin
763:Drugs for treatment of
571:resin with affinity to
1656:Bile acid sequestrants
1477:Ezetimibe/rosuvastatin
1472:Ezetimibe/atorvastatin
949:Bile acid sequestrants
599:
1482:Ezetimibe/simvastatin
895:Lipid-lowering agents
795:Polystyrene sulfonate
593:
457:bile acid sequestrant
1523:Alipogene tiparvovec
1249:Aluminium clofibrate
1108:Aluminium nicotinate
603:Notes and references
213:-imidazole copolymer
1259:Choline fenofibrate
843:Lanthanum carbonate
818:Aluminium hydroxide
485:peritoneal dialysis
23:
1628:Never to phase III
1507:Niacin/simvastatin
1497:Niacin/laropiprant
600:
473:hyperphosphataemia
19:
1651:Phosphate binders
1638:
1637:
1502:Niacin/lovastatin
1450:
1449:
1338:
1337:
1216:
1215:
1171:ATP citrate lyase
1128:Nicotinyl alcohol
1026:HMG-CoA reductase
1007:
1006:
861:
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833:Calcium carbonate
810:Phosphate binders
782:Potassium binders
769:hyperphosphatemia
654:10.2337/dc11-s237
561:2-methylimidazole
525:immunosuppressant
491:Contraindications
434:
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344:CompTox Dashboard
16:Chemical compound
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1387:PCSK9 inhibitors
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567:and works as an
453:phosphate binder
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1203:Dextrothyroxine
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823:Calcium acetate
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569:anion exchanger
565:epichlorohydrin
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535:Adverse effects
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451:that acts as a
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420:(what is this?)
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164:Protein binding
154:Bioavailability
146:Pharmacokinetic
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360:DTXSID40914950
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1222:Blood vessels
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1194:Thyromimetics
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1016:
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991:Soluble fiber
989:
987:
984:
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981:Colestyramine
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723:Austria-Codex
717:
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669:
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646:Diabetes Care
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529:antiepileptic
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443:, trade name
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333:ChEMBL2103800
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36:Clinical data
34:
30:
25:
1593:Volanesorsen
1455:Combinations
1427:inhibitors (
1269:Clinofibrate
1264:Ciprofibrate
1173:inhibitors (
1140:inhibitors (
1123:Nicofuranose
1074:Rosuvastatin
1064:Pitavastatin
1044:Cerivastatin
1039:Atorvastatin
970:
837:
765:hyperkalemia
722:
699:December 16,
697:. Retrieved
693:Adis Insight
692:
645:
635:
626:
595:
554:
538:
502:
499:Interactions
494:
483:, including
470:
467:Clinical use
461:
444:
436:
435:
424:
418:
210:
178:Not absorbed
158:Not absorbed
130:Legal status
124:Legal status
1614:from market
1573:Policosanol
1548:Lapaquistat
1528:Azacosterol
1405:Bococizumab
1377:Torcetrapib
1372:Obicetrapib
1367:Evacetrapib
1362:Dalcetrapib
1357:Anacetrapib
1309:Ronifibrate
1304:Pemafibrate
1294:Gemfibrozil
1289:Fenofibrate
1254:Bezafibrate
1161:Mitratapide
1151:Dirlotapide
1079:Simvastatin
1069:Pravastatin
1049:Fluvastatin
999:glucomannan
966:Colesevelam
579:anions and
193:Identifiers
42:Trade names
1645:Categories
1588:Triparanol
1563:Mipomersen
1543:Darapladib
1538:Benfluorex
1533:Azalanstat
1442:Evinacumab
1415:Inclisiran
1410:Evolocumab
1400:Alirocumab
1314:Simfibrate
1284:Etofibrate
1279:Clofibride
1274:Clofibrate
1208:Resmetirom
1156:Lomitapide
1118:Niceritrol
1059:Mevastatin
1054:Lovastatin
976:Colestipol
971:Colestilan
934:Hyzetimibe
838:Colestilan
594:2-methyl-1
475:(too high
449:medication
437:Colestilan
293:VSI302RYSR
268:ChemSpider
232:95522-45-5
223:CAS Number
202:IUPAC name
174:Metabolism
21:Colestilan
1624:Phase III
1612:Withdrawn
1299:Nafenopin
986:Colextran
939:SCH-48461
929:Ezetimibe
848:Sevelamer
790:Patiromer
577:bile acid
573:phosphate
557:copolymer
477:phosphate
184:Excretion
88:Routes of
70:Pregnancy
56:Drugs.com
1583:Tiadenol
1578:Probucol
1558:Meglutol
1330:GW501516
1241:Fibrates
1103:Acipimox
995:psyllium
993:such as
908:GI tract
672:21525463
481:dialysis
427:(verify)
100:ATC code
72:category
1425:ANGPTL3
1022:Statins
663:3632187
545:calcium
531:drugs.
447:) is a
445:BindRen
381:Formula
243:PubChem
116:)
110: (
108:V03AE06
46:BindRen
1607:WHO-EM
1323:Others
1196:(VLDL)
1113:Niacin
953:resins
921:NPC1L1
670:
660:
521:folate
519:) and
324:ChEMBL
313:D01934
1516:Other
1233:(LDL)
1013:Liver
773:V03AE
581:urate
257:65840
1142:VLDL
1138:MTTP
1092:and
997:and
767:and
701:2015
668:PMID
563:and
527:and
455:and
304:KEGG
284:UNII
275:none
148:data
94:Oral
52:AHFS
1433:HDL
1429:LDL
1391:LDL
1348:HDL
1175:LDL
1094:LDL
1090:HDL
1030:LDL
957:LDL
899:C10
658:PMC
650:doi
559:of
441:INN
393:ClN
349:EPA
247:CID
188:Gut
113:WHO
1647::
1620::
1028:,
919:,
709:^
691:.
680:^
666:.
656:.
644:.
611:^
575:,
515:,
511:,
507:,
487:.
409:O)
401:(C
385:(C
168:NA
1435:)
1431:/
1393:)
1389:(
1350:)
1346:(
1177:)
1144:)
1096:)
1032:)
1024:(
959:)
955:(
951:/
901:)
897:(
887:e
880:t
873:v
775:)
771:(
756:e
749:t
742:v
703:.
674:.
652::
596:H
517:K
513:E
509:D
505:A
439:(
411:n
407:6
405:H
403:3
399:m
397:)
395:2
391:5
389:H
387:4
351:)
347:(
211:H
79:B
54:/
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