429:, Mello recounted the phone call that he received announcing that he had won the prize. He recalls that it was shortly after 4:30 am and he had just finished checking on his daughter, and returned to his bedroom. The phone rang (or rather the green light was blinking) and his wife told him not to answer, as it was a prank call. Upon questioning his wife, she revealed that it had rung while he was out of the room and someone was playing a bad joke on them by saying that he had won the Nobel prize. When he told her that they were actually announcing the Nobel prize winners on this very day, he said "her jaw dropped." He answered the phone, and the voice on the other end told him to get dressed, and that in half an hour his life was about to change.
335:
discussions helped to build his confidence and self-esteem. Mello struggled during the first few years of grade school. He started first grade at the age of five in a local private school because he was too young to enter first grade in the public system. He doesn't know if he was a slow learner, or just not interested, but he did not do well in school until the seventh grade. In second grade, Mello only pretended that he could read and he was embarrassed by being called on in class. He much preferred playing outdoors, in the woods and creeks, to time spent in the classroom. Meanwhile, his older siblings were model students, raising the teacher's expectations for him. During these early years, Mello had no doubt that he would be a
367:
982:
42:
359:, his cell biology instructor, recounted that although he did not receive the "best grades of the class," he was intensely curious and thus a "real pain in the ass." Mello would never let Miller finish a lecture without asking him for more references, questions, or evidence for concepts discussed in the lecture. He received his
486:
counteracts these forces, it is a worldwide enterprise that unifies us and brings us together to solve problems and to understand our place in the world. Indeed, science tells us that we share a deep common history as a species, and that we will very likely share a common destiny as inhabitants of a small and fragile planet.
334:
The Mello family had a very strong tradition of discussions around the dinner table and this experience was very important to young Mello. He learned to argue, to listen, and to admit it when he was wrong about something. At a time when young Mello was not performing so well in school, these daily
485:
Science is a unifier. Science values questions rather than beliefs. Science provides a path for humans to learn about their world, it helps us to create new knowledge and advance our cultures. There are so many forces that divide people; barriers of language, custom, ideology, and belief. Science
509:
where he Chairs the
Scientific Advisory Board. In June 2010, he joined the Technology Advisory Board of Beeologics, a company focused on development of RNAi products for honeybee health and various veterinary and agricultural applications, which, according to Mello, "could very well be the first
403:
In 2006, Mello and Fire received the Nobel Prize for work that began in 1998, when Mello and Fire along with their colleagues (SiQun Xu, Mary
Montgomery, Stephen Kostas, and Sam Driver) published a paper in the journal
455:'s Human Genetics Unit, said: "It is very unusual for a piece of work to completely revolutionize the whole way we think about biological processes and regulation, but this has opened up a whole new field in biology."
288:
and were the first children in their respective families to attend college. His grandparents on both sides withdrew from school as teenagers to work for their families. James Mello completed his
639:
2889:
331:. Among Craig's fondest early memories were field trips with his father and the whole family to Colorado and Wyoming and more frequent trips to the Blue Ridge mountains in Virginia.
1049:
2844:
381:
for graduate studies in molecular, cellular and developmental biology with David Hirsh. After Hirsh decided to take a position in industry, Mello moved to
1042:
209:
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2592:
1058:
1012:
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201:
189:
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1035:
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273:
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where he could continue his research with Dan
Stinchcomb. Mello completed his Ph.D. at Harvard in 1990. He was a postdoctoral fellow at the
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997:
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He believes that "The science vs. religion debate is over" and that it is possible to "unite rationality and spirituality in a
436:, said: "This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information."
386:
237:
1002:
923:
2704:
1062:
1007:
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276:, was a paleontologist and his mother, Sally Mello, was an artist. His paternal grandparents immigrated to the US from the
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that celebrates the mysteries of existence and inspires each human being to achieve a higher purpose in life"
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Fire, Andrew; Xu, SiQun; Montgomery, Mary K.; Kostas, Steven A.; Driver, Samuel E.; Mello, Craig C. (1998).
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898:
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1783:
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2018:
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when he grew up. He is now the father of two daughters and a step-daughter and step-son.
8:
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2186:
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2070:
2034:
1994:
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1500:
1253:
1150:
1094:
1013:
Potent and specific genetic interference by double-stranded RNA in
Caenorhabditis elegans
742:
TEDxBrownUniversity - Kenneth Miller - What Makes the Brown
University Curriculum Unique?
564:
506:
451:
plays a key role in gene regulation. According to
Professor Nick Hastie, director of the
360:
2414:
1138:
981:
787:
2498:
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2237:
2126:
2006:
1966:
1950:
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1524:
1395:
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1323:
880:
807:
382:
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467:
and has been inspired by his essays on natural history and the philosophy of science.
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2619:
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2114:
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1938:
1863:
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1415:
1379:
1261:
1166:
799:
426:
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327:, when James Mello switched from the USGS to a position as assistant director at the
324:
197:
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2022:
1990:
1731:
884:
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1958:
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1508:
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111:
87:
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on
October 18, 1960. He was the third child of James and Sally Mello. His father,
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2325:
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2150:
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2014:
1914:
1879:
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1843:
1695:
1659:
1464:
1315:
1158:
767:
765:
582:
534:
297:
1791:
825:
477:
In his
October 2015 acceptance speech for a China Friendship Award from Premier
2687:
2662:
2410:
2337:
2317:
2293:
2269:
2253:
2214:
2210:
2142:
2118:
1982:
1978:
1934:
1918:
1831:
1815:
1799:
1795:
1571:
1423:
1371:
1249:
1182:
313:
740:
621:
in 2007. He gave the keynote
Baccalaureate Address at Commencement ceremonies.
418:) before it can produce a protein - effectively shutting specific genes down.
2823:
2737:
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2406:
2373:
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2190:
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556:
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76:
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1962:
1930:
1807:
1723:
1707:
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1655:
1643:
1631:
1387:
1375:
1355:
1234:
1226:
1142:
586:
293:
135:
41:
1057:
976:
803:
2712:
2643:
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2218:
2194:
2102:
1767:
1563:
1480:
1110:
1102:
1086:
863:
Horton, Richard (10 October 2015). "The underrated value of friendship".
560:
538:
269:
241:
193:
121:
72:
2245:
1504:
1452:
1399:
510:
company to obtain FDA approval for an RNAi therapy". In
September 2011
478:
2446:
1998:
899:"Beeologics Welcomes Nobel Prize Winner, Craig C... | MyPRGenie"
471:
336:
265:
169:
68:
1008:
US Patent 6506559 Genetic inhibition by double-stranded RNA (patent)
768:"Potent and specific genetic interference by double-stranded RNA in
2241:
511:
305:
277:
987:
Return to the RNAi World: Rethinking Gene Expression and Evolution
795:
224:(born October 18, 1960) is an American biologist and professor of
902:
281:
953:"Golden Plate Awardees of the American Academy of Achievement"
496:
289:
91:
415:
398:
351:. After receiving his high school diploma, Mello attended
2890:
Members of the United States National Academy of Sciences
829:
448:
411:
100:
414:
fool the cell into destroying the gene's messenger RNA (
1003:
Nobel announcement from the University of Massachusetts
571:
for Distinguished Work in Medical Research in 2005.
533:Co-recipient (with Andrew Fire, Thomas Tuschl and
924:"UMASS MEDICAL SCHOOL PROFESSOR WINS NOBEL PRIZE"
2821:
425:Scientific Meeting held on November 13, 2006 in
862:
662:Howard Hughes Medical Institute. Archived from
355:as a biochemistry and molecular biology major.
2845:Fairfax High School (Fairfax, Virginia) alumni
2600:
601:Dr. Paul Janssen Award for Biomedical Research
2586:
1043:
308:so that James could take a position with the
439:Mello and Fire's research, conducted at the
998:Nobel announcement from Stanford University
624:Recipient of the Golden Plate Award of the
312:(USGS) in Washington, DC. He was raised as
2593:
2579:
1050:
1036:
1023:University of Massachusetts Medical School
980:
928:University of Massachusetts Medical School
856:
594:Paul Ehrlich and Ludwig Darmstaedter Prize
497:Involvement in RNAi biotechnology industry
445:University of Massachusetts Medical School
230:University of Massachusetts Medical School
180:University of Massachusetts Medical School
40:
2865:Nobel laureates in Physiology or Medicine
710:
708:
706:
704:
702:
700:
501:Mello is involved in several RNAi-based
458:
365:
252:and published in 1998. Mello has been a
698:
696:
694:
692:
690:
688:
686:
684:
682:
680:
610:Co-recipient (with Andrew Fire) of the
592:Co-recipient (with Andrew Fire) of the
576:Gairdner Foundation International Award
574:Co-recipient (with Andrew Fire) of the
491:Craig Mello 2006 China Friendship Award
432:The Nobel citation, issued by Sweden's
349:Fairfax High School (Fairfax, Virginia)
143:Gairdner Foundation International Award
14:
2870:Scientists from New Haven, Connecticut
2822:
738:
631:Recipient of an honorary doctorate by
617:Recipient of an honorary doctorate by
387:Fred Hutchinson Cancer Research Center
238:Nobel Prize for Physiology or Medicine
2905:American people of Portuguese descent
2574:
1063:Nobel Prize in Physiology or Medicine
1031:
759:
612:Nobel Prize in Physiology or Medicine
329:Smithsonian Museum of Natural History
248:. This research was conducted at the
150:Nobel Prize in Physiology or Medicine
734:
732:
677:
517:
2855:Howard Hughes Medical Investigators
826:"Nobel prize for genetic discovery"
581:Co-recipient (with Andrew Fire and
530:Award in Molecular Biology in 2003.
526:Co-recipient (with Andrew Fire) of
389:in the laboratory of James Priess.
300:in 1962. The Mello family moved to
24:
2875:American people of Azorean descent
522:(By chronological year of award )
284:. His parents met while attending
250:Carnegie Institution of Washington
25:
2916:
2885:UMass Chan Medical School faculty
970:
729:
505:companies. He is a co-founder of
2900:21st-century American biologists
541:in the Biomedical Sciences from
447:(Mello), had shown that in fact
441:Carnegie Institution for Science
961:American Academy of Achievement
945:
749:from the original on 2021-12-19
626:American Academy of Achievement
423:Howard Hughes Medical Institute
410:detailing how tiny snippets of
379:University of Colorado, Boulder
310:United States Geological Survey
254:Howard Hughes Medical Institute
916:
891:
843:
818:
716:"Autobiography of Craig Mello"
652:
640:Hope Funds Award of Excellence
463:Mello admired and worked with
392:
129:NAS Award in Molecular Biology
13:
1:
877:10.1016/S0140-6736(15)00419-5
646:
259:
985:including the Nobel Lecture
930:. 2006-10-02. Archived from
550:National Academy of Sciences
528:National Academy of Sciences
342:
7:
2155:Christiane NĂĽsslein-Volhard
642:in Basic Research in 2008.
599:Inaugural recipient of The
27:American biologist (b.1960)
10:
2921:
396:
236:. He was awarded the 2006
2850:Harvard University alumni
2747:
2728:
2703:
2678:
2653:
2629:
2610:
2228:
1893:
1554:
1352:Charles Scott Sherrington
1328:Frederick Gowland Hopkins
1290:
1069:
569:Lewis S. Rosenstiel Award
256:investigator since 2000.
215:
185:
175:
165:
158:
117:
107:
83:
51:
39:
32:
2835:American Nobel laureates
2342:Françoise Barré-Sinoussi
453:Medical Research Council
234:Worcester, Massachusetts
2895:Massry Prize recipients
2880:Duke University faculty
2840:Brown University alumni
992:Nobel Prize information
851:Thank God for Evolution
660:"Craig C. Mello, Ph.D."
244:, for the discovery of
2753:Nobel Prize recipients
2705:Physiology or Medicine
1123:Santiago RamĂłn y Cajal
770:Caenorhabditis elegans
718:. The Nobel Foundation
543:Rockefeller University
494:
374:
323:, the family moved to
319:After a brief stay in
1624:Dickinson W. Richards
1308:Julius Wagner-Jauregg
605:Johnson & Johnson
514:acquired Beeologics.
483:
459:Philosophical outlook
369:
2047:Rita Levi-Montalcini
1408:Albert Szent-Györgyi
434:Karolinska Institute
372:World Economic Forum
363:from Brown in 1982.
2439:William C. Campbell
2350:Elizabeth Blackburn
2187:Robert F. Furchgott
2179:Stanley B. Prusiner
2171:Rolf M. Zinkernagel
2071:George H. Hitchings
2035:Joseph L. Goldstein
1995:Bengt I. Samuelsson
1824:Earl Sutherland Jr.
957:www.achievement.org
788:1998Natur.391..806F
565:Brandeis University
555:Co-recipient (with
507:RXi Pharmaceuticals
377:Mello attended the
361:Bachelor of Science
222:Craig Cameron Mello
34:Craig Cameron Mello
2499:William Kaelin Jr.
2495:Peter J. Ratcliffe
2238:Leland H. Hartwell
2127:Richard J. Roberts
2007:Barbara McClintock
1951:Godfrey Hounsfield
1852:Nikolaas Tinbergen
1784:Marshall Nirenberg
1752:Charles B. Huggins
1541:Tadeusz Reichstein
1529:AntĂłnio Egas Moniz
1324:Christiaan Eijkman
979:on Nobelprize.org
559:, Andrew Fire and
383:Harvard University
375:
370:Mello at the 2015
264:Mello was born in
226:molecular medicine
97:Harvard University
2817:
2816:
2730:Economic Sciences
2620:Roger D. Kornberg
2568:
2567:
2533:Ardem Patapoutian
2382:Ralph M. Steinman
2378:Jules A. Hoffmann
2366:Robert G. Edwards
2334:Harald zur Hausen
2258:H. Robert Horvitz
2159:Eric F. Wieschaus
2095:E. Donnall Thomas
2079:J. Michael Bishop
2067:Gertrude B. Elion
1939:Hamilton O. Smith
1864:Christian de Duve
1600:Frederick Robbins
1477:Alexander Fleming
1416:Corneille Heymans
1262:Frederick Banting
1167:Allvar Gullstrand
782:(6669): 806–811.
638:Recipient of the
518:Awards and honors
427:Ashburn, Virginia
325:Fairfax, Virginia
219:
218:
210:Daniel Stinchcomb
186:Academic advisors
160:Scientific career
147:
126:
16:(Redirected from
2912:
2755:
2595:
2588:
2581:
2572:
2571:
2561:
2546:
2535:
2520:
2514:Michael Houghton
2501:
2491:Gregg L. Semenza
2485:
2479:James P. Allison
2473:
2471:Michael W. Young
2457:
2455:Yoshinori Ohsumi
2449:
2433:
2417:
2415:Thomas C. SĂĽdhof
2401:
2389:
2368:
2360:
2354:Carol W. Greider
2344:
2328:
2312:
2300:
2288:
2276:
2264:
2248:
2221:
2205:
2197:
2181:
2173:
2167:Peter C. Doherty
2161:
2145:
2139:Alfred G. Gilman
2133:
2121:
2109:
2097:
2085:
2083:Harold E. Varmus
2073:
2057:
2049:
2037:
2025:
2009:
2001:
1985:
1969:
1959:Baruj Benacerraf
1953:
1941:
1925:
1909:
1886:
1870:
1854:
1838:
1826:
1818:
1802:
1786:
1776:Robert W. Holley
1770:
1754:
1742:
1726:
1714:
1698:
1682:
1680:Georg von Békésy
1674:
1662:
1650:
1648:Joshua Lederberg
1634:
1626:
1620:Werner Forssmann
1610:
1602:
1586:
1574:
1566:
1547:
1531:
1519:
1511:
1509:Bernardo Houssay
1495:
1487:
1471:
1459:
1447:
1446:
1440:
1439:
1433:
1432:
1426:
1418:
1410:
1402:
1390:
1382:
1366:
1358:
1346:
1338:
1336:Karl Landsteiner
1330:
1318:
1310:
1302:
1300:Johannes Fibiger
1283:
1282:
1276:
1274:Willem Einthoven
1268:
1256:
1244:
1243:
1237:
1229:
1221:
1220:
1214:
1213:
1207:
1206:
1200:
1199:
1193:
1185:
1177:
1169:
1161:
1153:
1145:
1139:Élie Metchnikoff
1133:
1131:Alphonse Laveran
1125:
1113:
1105:
1097:
1089:
1081:
1052:
1045:
1038:
1029:
1028:
984:
965:
964:
949:
943:
942:
940:
939:
920:
914:
913:
911:
910:
901:. Archived from
895:
889:
888:
860:
854:
847:
841:
840:
838:
837:
822:
816:
815:
763:
757:
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755:
754:
736:
727:
726:
724:
723:
712:
675:
674:
672:
671:
656:
619:Brown University
492:
465:Stephen J. Gould
353:Brown University
286:Brown University
246:RNA interference
154:
145:
140:
133:
124:
112:RNA interference
88:Brown University
65:
62:October 18, 1960
61:
59:
44:
30:
29:
21:
2920:
2919:
2915:
2914:
2913:
2911:
2910:
2909:
2820:
2819:
2818:
2813:
2751:
2743:
2740:(United States)
2724:
2721:(United States)
2715:(United States)
2699:
2696:(United States)
2690:(United States)
2674:
2649:
2625:
2622:(United States)
2606:
2599:
2569:
2564:
2549:
2538:
2523:
2518:Charles M. Rice
2510:Harvey J. Alter
2504:
2488:
2476:
2467:Michael Rosbash
2463:Jeffrey C. Hall
2460:
2452:
2436:
2427:May-Britt Moser
2420:
2404:
2399:Shinya Yamanaka
2392:
2371:
2363:
2358:Jack W. Szostak
2347:
2331:
2326:Oliver Smithies
2315:
2303:
2291:
2279:
2274:Peter Mansfield
2267:
2262:John E. Sulston
2251:
2235:
2224:
2208:
2200:
2184:
2176:
2164:
2151:Edward B. Lewis
2148:
2136:
2124:
2112:
2100:
2088:
2076:
2060:
2055:Susumu Tonegawa
2052:
2040:
2028:
2012:
2004:
1988:
1972:
1956:
1944:
1928:
1915:Roger Guillemin
1912:
1907:Daniel Gajdusek
1903:Baruch Blumberg
1900:
1889:
1880:Renato Dulbecco
1876:David Baltimore
1873:
1857:
1844:Karl von Frisch
1841:
1829:
1821:
1805:
1789:
1773:
1764:Haldan Hartline
1757:
1745:
1729:
1717:
1701:
1696:Maurice Wilkins
1685:
1677:
1665:
1660:Arthur Kornberg
1653:
1637:
1629:
1613:
1605:
1589:
1577:
1569:
1561:
1550:
1534:
1522:
1514:
1498:
1490:
1474:
1465:Joseph Erlanger
1462:
1450:
1444:
1443:
1437:
1436:
1430:
1429:
1421:
1413:
1405:
1393:
1385:
1369:
1361:
1349:
1341:
1333:
1321:
1316:Charles Nicolle
1313:
1305:
1297:
1286:
1280:
1279:
1271:
1259:
1247:
1241:
1240:
1232:
1224:
1218:
1217:
1211:
1210:
1204:
1203:
1197:
1196:
1188:
1180:
1172:
1164:
1159:Albrecht Kossel
1156:
1148:
1136:
1128:
1116:
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54:
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46:Mello in 2014
43:
38:
31:
19:
2783:
2718:
2694:George Smoot
2671:(Bangladesh)
2669:Grameen Bank
2665:(Bangladesh)
2544:Svante Pääbo
2529:David Julius
2483:Tasuku Honjo
2431:Edvard Moser
2423:John O'Keefe
2386:posthumously
2385:
2322:Martin Evans
2309:
2298:Robin Warren
2282:Richard Axel
2229:2001–present
2107:Bert Sakmann
1975:Roger Sperry
1967:George Snell
1963:Jean Dausset
1931:Werner Arber
1884:Howard Temin
1808:Bernard Katz
1792:Max DelbrĂĽck
1748:Francis Rous
1724:Feodor Lynen
1720:Konrad Bloch
1708:Alan Hodgkin
1692:James Watson
1668:Frank Burnet
1656:Severo Ochoa
1644:Edward Tatum
1632:Daniel Bovet
1545:Philip Hench
1457:Edward Doisy
1388:Hans Spemann
1376:George Minot
1356:Edgar Adrian
1344:Otto Warburg
1266:John Macleod
1235:August Krogh
1227:Jules Bordet
1143:Paul Ehrlich
1095:Niels Finsen
1079:Emil Behring
1016:
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947:
936:. Retrieved
932:the original
918:
907:. Retrieved
903:the original
893:
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834:. Retrieved
832:. 2006-10-02
820:
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751:, retrieved
741:
739:TEDx Talks,
720:. Retrieved
668:. Retrieved
664:the original
654:
587:Massry Prize
521:
500:
484:
481:Mello said,
476:
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376:
346:
333:
321:Falls Church
318:
304:in northern
302:Falls Church
294:paleontology
263:
221:
220:
176:Institutions
159:
136:Massry Prize
2830:1960 births
2719:Craig Mello
2713:Andrew Fire
2644:Orhan Pamuk
2603:Nobel Prize
2395:John Gurdon
2310:Craig Mello
2306:Andrew Fire
2219:Eric Kandel
2195:Ferid Murad
2103:Erwin Neher
2015:Niels Jerne
1780:Har Khorana
1768:George Wald
1736:André Lwoff
1704:John Eccles
1592:John Enders
1564:Max Theiler
1525:Walter Hess
1517:Paul MĂĽller
1481:Ernst Chain
1151:Emil Kocher
1111:Robert Koch
1103:Ivan Pavlov
1087:Ronald Ross
849:Commending
561:Gary Ruvkun
539:Wiley Prize
393:Nobel prize
280:islands of
274:James Mello
270:Connecticut
194:Susan Gerbi
122:Wiley Prize
73:Connecticut
2824:Categories
2631:Literature
2246:Paul Nurse
1580:Hans Krebs
1505:Gerty Cori
1453:Henrik Dam
1400:Otto Loewi
1396:Henry Dale
938:2006-10-02
909:2010-06-10
865:The Lancet
836:2006-10-02
753:2018-12-29
722:2007-12-31
670:2007-12-31
647:References
479:Li Keqiang
397:See also:
278:Portuguese
260:Early life
198:Ken Miller
58:1960-10-18
2612:Chemistry
2605:laureates
2447:Tu Youyou
1999:John Vane
1894:1976–2000
1555:1951–1975
1501:Carl Cori
1291:1926–1950
1070:1901–1925
1059:Laureates
537:) of the
472:worldview
343:Education
337:scientist
266:New Haven
170:Biologist
69:New Haven
2646:(Turkey)
2242:Tim Hunt
885:54350254
747:archived
635:in 2008.
628:in 2007.
614:in 2006.
607:in 2006.
596:in 2006.
589:in 2005.
578:in 2005.
552:in 2005.
545:in 2003.
512:Monsanto
489:—
306:Virginia
2680:Physics
1061:of the
812:4355692
804:9486653
784:Bibcode
228:at the
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2477:2018:
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