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31:
266:, a new company focused on health, well-being, and longevity. Prior to that, she served as a part-time advisor beginning in November 2013. Kenyon remains affiliated with UCSF as an emeritus professor.
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Kenyon's research prompted her to make personal dietary changes. In 2000, when she discovered that putting sugar on the worms' food shortened their lifespans, she stopped eating high
320:. Kenyon's findings have led to the discovery that an evolutionarily conserved hormone signaling system influences aging in other organisms, perhaps also including mammals.
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281:. These findings demonstrated that Hox genes were not simply involved in segmentation, as thought, but instead were part of a much more ancient and fundamental
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effect was due to the mutation itself rather than due to caloric restriction. In 1993, Kenyon's discovery that a single-gene mutation (
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Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type".
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where, in Graham Walker's laboratory, she looked for genes on the basis of their activity profiles, discovering that
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could be altered by mutations, but Klass believed that the effect was due to reduced food consumption (
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to try to discover and develop drugs that would slow down the process that makes people age.
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Calico Life
Sciences, LLC; Professor emeritus University of California San Francisco (UCSF)
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Klass MR (1983). "A method for the isolation of longevity mutants in the nematode
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751:"Zehnter "Ilse und Helmut Wachter-Preis" an deutschen Pionier der Genforschung"
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Cynthia Kenyon graduated valedictorian in chemistry and biochemistry from the
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2005 Ilse & Helmut
Wachter Award for Exceptional Scientific Achievement
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1003:, an open-access interview discussing Kenyon's research and her personal
727:"Award for Distinguished Research in the Biomedical Sciences Recipients"
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801:"Inspire Awards 2008 Honorees - Cynthia Kenyon, Longevity Researcher"
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In April 2014, Kenyon was named Vice
President of Aging Research at
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273:, which were known to pattern the body segments of the fruit fly (
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181:, and emeritus professor of biochemistry and biophysics at the
652:"1998 Senior Scholar, Cynthia Kenyon, Wins King Faisal Prize"
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diet for two days, but couldn't stand the constant hunger.
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186:
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Members of the United States
National Academy of Sciences
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Cynthia Kenyon Talk: A Genetic
Control Circuit for Aging
308:
and that this could be reversed by a second mutation in
217:. She then did postdoctoral studies with Nobel laureate
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235:
Since 1986 she has been at the UCSF, where she was the
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lengthens life and reduces hermaphrodite fertility"
991:Cynthia Kenyon's Seminar: Genes that Control Aging
177:. She is the vice president of aging research at
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923:
921:
1080:University of California, San Francisco faculty
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918:
201:in 1976. She received her Ph.D. in 1981 from
1075:Massachusetts Institute of Technology alumni
382:for the Future – Aging: Facing the Challenge
296:). Thomas Johnson later showed that the 65%
1110:Members of the National Academy of Medicine
873:
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344:United States National Academy of Sciences
288:Michael Klass discovered that lifespan of
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269:Her early work led to the discovery that
731:Association of American Medical Colleges
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356:Association of American Medical Colleges
155:(born February 21, 1954) is an American
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631:American Academy of Arts & Sciences
441:Duncan, David Ewing (August 15, 2007).
229:, England, studying the development of
209:-damaging agents activate a battery of
183:University of California, San Francisco
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798:
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331:American Academy of Arts and Sciences
60:Massachusetts Institute of Technology
928:Kingsland, James (18 October 2003).
466:Mechanisms of Ageing and Development
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163:known for her genetic dissection of
402:carbohydrates and started eating a
251:Professor. In 1999, she co founded-
223:MRC Laboratory of Molecular Biology
115:MRC Laboratory of Molecular Biology
13:
947:Platoni, Kara (January 18, 2006).
825:"Cynthia Kenyon - Dan David Prize"
755:Medizinische Universität Innsbruck
431:
406:. She briefly experimented with a
14:
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799:Guroff, Margaret (January 2008).
507:Friedman DB, Johnson TE (1988).
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358:Award for Distinguished Research
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701:"Past and Present GSA Officers"
304:) could double the lifespan of
981:Basic Research: Cynthia Kenyon
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656:The Ellison Medical Foundation
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1:
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1070:University of Georgia alumni
893:10.1371/journal.pbio.0020012
681:National Academy of Sciences
478:10.1016/0047-6374(83)90082-9
7:
1105:21st-century American women
874:O'Neill, B (January 2004).
850:"2021 Dickson Prize Winner"
413:
350:Genetics Society of America
277:) also pattern the body of
239:Distinguished Professor of
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1126:
1055:American women geneticists
1035:American women biochemists
1065:Women medical researchers
542:10.1093/genetics/118.1.75
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930:"I want to live forever"
854:University of Pittsburgh
987:, vol. 25, no. 11, 2004
876:"In Methuselah's Mould"
249:American Cancer Society
1040:American biophysicists
515:Caenorhabditis elegans
464:and initial results".
462:Caenorhabditis elegans
253:Elixir Pharmaceuticals
174:Caenorhabditis elegans
16:US molecular biologist
1001:In Methuselah's Mould
949:"Live, Fast, Die Old"
703:. GSA. Archived from
447:MIT Technology Review
404:low-carbohydrate diet
199:University of Georgia
1045:American geneticists
983:by Steven Kotler in
776:"Annual Report 2006"
179:Calico Research Labs
1050:Women biophysicists
829:The Dan David Prize
757:. November 30, 2018
677:"Cynthia J. Kenyon"
627:"Cynthia J. Kenyon"
589:1993Natur.366..461K
509:"A mutation in the
408:calorie restriction
294:caloric restriction
285:patterning system.
157:molecular biologist
153:Cynthia Jane Kenyon
1100:Life extensionists
831:. 11 November 2021
707:on 4 December 2018
368:Prize in Longevity
366:La Fondation IPSEN
1060:Biogerontologists
959:on March 11, 2007
583:(6454): 461–464.
420:Genetics of aging
337:King Faisal Prize
324:Awards and honors
167:in a widely used
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94:Scientific career
48:February 21, 1954
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955:. Archived from
953:East Bay Express
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472:(3–4): 279–286.
457:
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443:"The Enthusiast"
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348:2003 President,
314:Leonard Guarente
257:Leonard Guarente
171:, the roundworm
161:biogerontologist
137:Coleen T. Murphy
133:Notable students
127:Graham C. Walker
122:Doctoral advisor
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56:Alma mater
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975:External links
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658:. May 14, 2000
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318:David Sinclair
298:life extension
247:and is now an
219:Sydney Brenner
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169:model organism
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375:Inspire Award
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342:2003 Member,
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50:(age 70)
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961:. Retrieved
957:the original
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880:PLOS Biology
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833:. Retrieved
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783:. Retrieved
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734:. Retrieved
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709:. Retrieved
705:the original
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635:. Retrieved
633:. April 2023
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536:(1): 75–86.
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389:in Medicine.
339:for Medicine
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241:Biochemistry
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110:Institutions
93:
70:
1090:1955 births
711:27 November
231:C. elegans.
1029:Categories
886:(1): E12.
860:2023-06-05
835:2023-06-05
810:2023-06-05
785:2023-06-05
761:2023-06-05
736:2023-06-05
686:2023-06-05
662:2023-06-05
637:2023-06-05
426:References
306:C. elegans
290:C. elegans
279:C. elegans
275:Drosophila
245:Biophysics
211:DNA repair
72:C. elegans
44:1954-02-21
271:Hox genes
227:Cambridge
213:genes in
104:Biologist
69:Aging in
985:Discover
912:14758367
529:Genetics
513:gene in
414:See also
283:metazoan
963:July 3,
781:. Ipsen
613:4332206
605:8247153
585:Bibcode
560:8608934
551:1203268
494:6870538
486:6632998
310:daf-16m
221:at the
215:E. coli
910:
903:322746
900:
611:
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576:Nature
558:
548:
492:
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264:Calico
193:Career
100:Fields
79:Awards
779:(PDF)
609:S2CID
511:age-1
490:S2CID
385:2021
378:2011
371:2008
364:2006
354:2004
335:2000
302:Daf-2
255:with
165:aging
965:2007
908:PMID
805:AARP
713:2018
601:PMID
556:PMID
482:PMID
373:AARP
316:and
243:and
187:UCSF
159:and
38:Born
1015:TED
1013:at
898:PMC
888:doi
593:doi
581:366
546:PMC
538:doi
534:118
522:PDF
474:doi
225:in
207:DNA
203:MIT
189:).
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