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417:"Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet"
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InChI=1S/C15H17NO3S/c1-9-2-3-11-10(6-9)4-5-16(15(11)20)14-7-12(18)13(8-17)19-14/h2-6,12-14,17-18H,7-8H2,1H3/t12-,13+,14+/m0/s1
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of d5SICS and dNaM are placed in parallel planes instead of the same plane. The d5SICS-dNaM pairing replaced an older dNaM-
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in a hydrophobic interaction. It was not able to be removed by the error-correcting machinery of the
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into which it was inserted. The pairing of d5SICS–dNaM is mediated by packing and
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Except where otherwise noted, data are given for materials in their
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476:"Structural Insights into DNA Replication Without Hydrogen-Bonds"
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365:, which occurs in natural base pairs. Therefore, in free DNA,
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57:-pentofuranosyl)-6-methylisoquinoline-1(2
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340:-1-thione-2-yl group instead of a base.
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235:Key: ISOKBQJGUJTDAE-BFHYXJOUSA-N
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629:Heterocyclic compounds with 2 rings
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256:OCC3OC(N2C=Cc1cc(ccc1C2=S)C)CC3(O)
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474:Betz, Karin; et al. (2013).
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261:Cc1ccc2c(c1)ccn(c2=S)3C((O3)CO)O
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523:Ben Guarino (24 January 2017).
314:(at 25 °C , 100 kPa).
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562:. You can help Knowledge by
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72:2--6-methylisoquinoline-1(2
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304:291.37 g/mol
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415:Malyshev, D. A. (2012).
634:Molecular biology stubs
442:10.1073/pnas.1205176109
624:Nitrogen heterocycles
68:Systematic IUPAC name
433:2012PNAS..10912005M
427:(30): 12005–12010.
336:containing 6-methyl
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359:hydrophobic forces
318:Infobox references
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614:Synthetic biology
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556:molecular biology
492:10.1021/ja409609j
332:is an artificial
326:Chemical compound
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564:expanding it
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398:. Retrieved
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338:isoquinoline
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100:1010689-00-5
83:Identifiers
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54:
619:Thioketones
609:Nucleosides
361:instead of
270:Properties
603:Categories
377:References
334:nucleoside
300:Molar mass
142:ChemSpider
111:3D model (
90:CAS Number
46:IUPAC name
373:pairing.
176:102129314
510:24283923
461:22773812
400:July 29,
345:pairs up
294:S
151:58191598
76:)-thione
61:)-thione
501:3982147
452:3409741
429:Bibcode
395:Rsc.org
354:E. coli
163:PubChem
55:erythro
17:d5SICS
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330:d5SICS
249:SMILES
40:Names
554:This
371:dTPT3
367:rings
347:with
224:InChI
113:JSmol
560:stub
506:PMID
457:PMID
402:2015
349:dNaM
496:PMC
488:doi
484:135
447:PMC
437:doi
425:109
343:It
193:EPA
166:CID
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292:3
286:H
282:C
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74:H
59:H
53:-
51:D
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