29:
532:
Andy
Devereux-Cooke; Sian Leary; Simon J. McGrath; Emma Northwood; Anna Redshaw; Charles Shepherd; Pippa Stacey; Claire Tripp; Jim Wilson; Margaret Mar; Danielle Boobyer; Sam Bromiley; Sonya Chowdhury; Claire Dransfield; Mohammed Almas; Øyvind Almelid; David Buchanan; Diana Garcia; John Ireland;
95:
The study announced receipt of funding in June 2020, and recruitment was opened on 12 September 2022. In
January 2023, the team wrote that over 17,000 patients had completed the survey, of which almost 9,000 were sent collection kits. On 2 May 2023 they announced that over 10,000 people had been
55:
ME/CFS is a chronic medical condition that often causes significant disability, and whose cause is unknown. Genetic studies of ME/CFS have been done before, but without significant findings. The authors of a 2022 study suggested that research with more participants is needed to discover
99:
In June 2023, DecodeME made changes to their data analysis methodology that allowed them to invite additional participants to give DNA. Recruitment is expected to close on 15 November. Recruitment for the study closed on 15 November 2023.
86:
The investigators hope the study's findings will inform further research into the pathology of ME/CFS and potential treatments. They also hope that discovering a genetic connection will help dispel some of the stigma around ME/CFS.
128:. There will also be a survey to collect data on symptoms. Results are expected to be published by September 2024. If new risk factors are identified, it may enable further research into potential causes, tests, or treatments.
236:
Hajdarevic, Riad; Lande, Asgeir; Mehlsen, Jesper; Rydland, Anne; Sosa, Daisy D.; Strand, Elin B.; Mella, Olav; Pociot, Flemming; Fluge, Øystein; Lie, Benedicte A.; Viken, Marte K. (2022-05-01).
108:
DecodeME is a genome-wide association study with a case-control design. Expected recruitment is at least 20,000 patients whose onset was not associated with COVID-19, and 5,000 people with
47:. With a planned recruitment of 25,000 patients, it is expected to be the largest such study to date. Recruitment closed on 15 November 2023 and results are expected in 2024.
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Shona M. Kerr; Isabel Lewis; Ewan McDowall; Malgorzata Migdal; Phil Murray; David Perry; Chris P. Ponting; Veronique Vitart; Jareth C. Wolfe (19 Jul 2022).
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83:. The researchers have also worked with Forward ME and a group of patient advocates, the latter of which contributed to the design of the study.
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213:"Recommendations | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management | Guidance | NICE"
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238:"Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci"
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This article is about the ongoing study whether ME/CFS has a genetic risk factor. For the defunct genome testing service, see
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535:"DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndrome"
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304:"How will you ensure that you have the support of the community of people with ME/CFS for this project?"
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DecodeME aims to perform such a large study. It is being run as a partnership between
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152:"UK to launch world's largest genetic study into chronic fatigue syndrome"
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609:"The world's largest study of chronic fatigue syndrome to launch in UK"
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as chief investigator, and with £3.2 million in funding from the UK's
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384:"People with ME invited to take part in major genetic study"
332:"People with ME invited to take part in major genetic study"
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at home and control samples will be obtained from the
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will be collected by sending patients kits to collect
181:"Chronic fatigue syndrome: Search for genetic clues"
810:Myalgic encephalomyelitis/chronic fatigue syndrome
672:Myalgic encephalomyelitis/chronic fatigue syndrome
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585:"How long will the GWAS study take to complete?"
509:"Closing participant recruitment - Thank you!"
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460:"Inviting More Participants to Donate DNA"
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434:"We've reached 10,000 DNA participants!"
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356:"Major study hopes to tackle ME stigma"
43:searching for genetic risk factors for
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81:National Institute for Health Research
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112:who were diagnosed with ME/CFS after
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330:Carmichael, Hannah (2022-09-11).
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507:Connolly, Anne (2023-11-15).
242:Brain, Behavior, and Immunity
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41:genome-wide association study
179:O'Neill, Sean (2020-06-23).
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552:10.1186/s12883-022-02763-6
458:Lewis, Issy (2023-06-16).
410:"What We Achieved in 2022"
408:Lewis, Issy (2023-01-31).
96:asked to provide samples.
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255:10.1016/j.bbi.2022.03.010
58:statistically significant
32:The study's official logo
774:Open Medicine Foundation
77:Medical Research Council
779:Solve ME/CFS Initiative
696:Post-exertional malaise
69:University of Edinburgh
16:Genetic study on ME/CFS
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617:. Retrieved
615:. 2020-06-23
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362:. 2023-09-21
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248:: 362–369.
104:Methodology
799:Categories
701:2-day CPET
619:2022-07-31
594:2022-07-31
545:(1): 269.
518:2023-11-16
493:2023-09-22
469:2023-09-22
444:2023-05-29
440:. DecodeME
419:2023-02-01
394:2022-09-12
366:2023-09-22
341:2022-09-12
313:2022-07-31
222:2022-07-31
198:2022-07-31
162:2022-07-31
132:References
126:UK Biobank
110:long COVID
51:Background
691:Treatment
290:247549585
274:0889-1591
193:0140-0460
185:The Times
717:DecodeME
710:Research
589:DecodeME
571:35854226
513:DecodeME
488:DecodeME
464:DecodeME
414:DecodeME
308:DecodeME
282:35318112
114:COVID-19
79:and the
67:and the
37:DecodeME
733:History
562:9294749
438:Twitter
91:History
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484:"Home"
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122:saliva
45:ME/CFS
286:S2CID
567:PMID
278:PMID
270:ISSN
189:ISSN
557:PMC
547:doi
260:hdl
250:doi
246:102
118:DNA
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
