574:, with high numbers of infected mosquitoes. The virus is transmitted to humans through the bites of infected female mosquitoes, though humans are not capable of transmitting the disease and are not contagious. The incubation period is 3 to 14 days, while the period of the illness is 3–7 days. Signs and symptoms may include severe headache; retro-orbital pain; muscle, joint, and bone pain; macular or maculopapular rash; and minor hemorrhagic manifestations, including petechiae, ecchymosis, purpura, epistaxis, bleeding gums, hematuria, or a positive tourniquet test result. A recent systematic review and meta-analysis showed that allergic symptoms are one of the core symptoms that are highly associated with dengue severity.
303:
773:. When macrophages consume the 'neutralized' virus, the virus is able to replicate within the macrophage, causing disease. These cross-reactive, ineffective antibodies ease access of the virus into macrophages, which induces more severe disease (dengue hemorrhagic fever, dengue shock syndrome). A common problem faced in dengue-endemic regions is when mothers become infected with dengue; after giving birth, offspring carry the immunity from their mother and are susceptible to hemorrhagic fever if infected with any of the other three serotypes. One vaccine was in phase III trials in 2012 and planning for vaccine usage and effectiveness surveillance had started.
421:
484:
dependent on the presence of a 43 amino acid segment of the NS2B cofactor. This cofactor wraps around the NS3 protease domain and becomes part of the active site. The remaining NS2B residues before and after the cofactor region contain helical domains involved in membrane binding. The remaining NS3 residues (180–618) form the three subdomains of the DENV helicase. A six-stranded parallel β-sheet surrounded by four α-helices makes up subdomains I and II, and subdomain III is composed of four α-helices surrounded by three shorter α-helices and two antiparallel β-strands.
798:(France). This unit produces four-serotype vaccine for phase III trials. In September 2014, the Sanofi-Pasteur CEO gave early results of the phase III trial efficacy study in Latin America. The efficacy per serotype (ST) varied widely, 42.3% for ST2, 50.3% for ST1, 74.0% for ST3, and 77.7% for ST4. The full analysis of data from the phase III Latin American-Caribbean study will be reviewed by external experts before being published in a peer-reviewed scientific journal. Primary results has to be presented at the
63:
471:
travels via the secretory pathway to the Golgi apparatus. As the virion passes through the trans-Golgi network, it is exposed to low pH. This acidic environment causes a conformational change in the E protein, which disassociates it from the prM protein and causes it to form E homodimers, which lie flat against the viral surface, giving the maturing virion a smooth appearance. During this maturation, pr peptide is cleaved from the M peptide by the host protease,
4246:
692:- the presence of this 105-kDa protein results in inactivation of STAT2 (via the signal transduction of the response to interferon) when it is expressed alone. When NS5 is cleaved with NS4B by a protease (NS2B3), it can degrade STAT2. In fact, after the cleavage of NS5 by the protease, an E3 ligase association with STAT2 occurs, and the E3 ligase targets STAT2 for the degradation.
31:
738:. Although immune responses against D7 proteins might impair their antiviral activity, a study showed that non-DENV subjects have slightly higher anti-D7 IgG levels than infected ones, although it was not statistically significant. Thus, more studies over D7 protein family are needed do elucidate its role on DENV infection and its applicability in medicine.
475:. The M protein then acts as a transmembrane protein under the E-protein shell of the mature virion. The pr peptide stays associated with the E protein until the viral particle is released into the extracellular environment. This pr peptide acts like a cap, covering the hydrophobic fusion loop of the E protein until the viral particle has exited the cell.
734:
was thought to assist the process of blood feeding. Despite the prior assumptions, D7 can modulate the host cell and act against the virus to prevent viral infection. Unfortunately, D7 proteins provoke immune responses, which raise anti-D7 antibody levels. These antibodies inhibit the function of D7 proteins, which enhance transmission of
733:
The immune responses of antibodies that are trying to fight off the foreign virus actually increase transmission and make the infection worse. Levels of protein D7 are more prevalent in salivary glands of dengue-infected mosquitoes compared to those uninfected ones. D7 is found in mosquito saliva and
363:
response, not to mention apoptosis, are triggered depending on the infected cell type. The activation of autophagy and ER stress during infection enhances virus reproduction. Attempts to provide detailed summaries of the life cycle of dengue at the cellular level are published in review articles from
437:
The DENV E (envelope) protein, found as a dimer on the surface of the mature viral particle, is important in the initial attachment of this particle to the host cell. Each E protein monomer comprises three ectodomains, ED1 to ED3, and a transmembrane segment. ED2 includes the dimerization interface,
510:
Crystal structures of complexes between antibodies and either the ectodomain (sE) of the viral E protein or its domain 3 (ED3) have helped understand the molecular bases of the virus recognition and neutralization. Some of the epitopes are partially or totally inaccessible in the known structure of
501:
The DENV NS5 protein is a 900-residue peptide with a methyltransferase domain at its N-terminal end (residues 1–296) and a RNA-dependent RNA polymerase (RdRp) at its C-terminal end (residues 320–900). The methyltransferase domain consists of an α/β/β sandwich flanked by N-and C-terminal subdomains.
760:
approved Qdenga, a live tetravalent attenuated vaccine for adults, adolescents and children from four years of age. The 2016 vaccine
Dengvaxia is only recommended in individuals who have been previously infected, or in populations with a high rate of prior infection by age nine. Dengvaxia has been
526:
The murine antibody 4E11 neutralizes all four DENV serotypes with varying efficacies. Its scFv fragment was crystallized in complex with the ED3 domains of the four DENV serotypes. Its epitope straddles β-strands A and G of ED3 as does the epitope of 1A1D-2. The structures at 2.0 Å resolution have
483:
The DENV NS3 is a serine protease, as well as an RNA helicase and RTPase/NTPase. The protease domain consists of six β-strands arranged into two β-barrels formed by residues 1–180 of the protein. The catalytic triad (His-51, Asp-75 and Ser-135) is found between these two β-barrels, and activity is
811:
On May 1, 2019, the U.S. Food and Drug
Administration announced the approval of Dengvaxia, the first vaccine for the prevention of dengue disease caused by all dengue virus serotypes in people ages 9 through 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas.
561:
fever; dengue hemorrhagic fever and dengue shock syndrome are the severe forms. Dengue is found in tropical and subtropical climates worldwide, mostly in urban and semiurban areas. People of all ages who are exposed to infected mosquitoes are at risk of developing dengue fever. The disease occurs
470:
shell of the mature DENV virion consists of 180 copies each of the E and M proteins. The immature virion starts out with the E and prM proteins forming 90 heterodimers that give a spiky exterior to the viral particle. This immature viral particle buds into the endoplasmic reticulum and eventually
764:
Several vaccines are under development by private and public researchers. Developing a vaccine against the disease is challenging. With four different serotypes of the virus that can cause the disease, the vaccine must immunize against all four types to be effective. Vaccination against only one
842:
Although there are no approved direct antiviral treatments for dengue fever, most antiviral research has focused on inhibiting the NS2B/NS3 protease or NS5 proteins. Reported protease inhibitor approaches have mainly targeted covalent inhibitors. One drug, Balapiravir, initially repurposed as a
533:
The human antibodies Ede1-C10, Ede2-A11, and Ede2-B7 potently neutralize all four DENV serotypes. Their Fab or scFv fragments were crystallized in complex with the sE protein of DENV2. The recognition determinants of these antibodies are at a serotype-invariant site in the E dimer interface and
450:
may also be involved in the attachment. E protein is known to contain physicochemically conserved B cells and T cells specific epitopes, which can be exploited to design vaccine. Recombinant domains of the E protein are used as well-defined antigens in the serological detection of antibodies
250:
has increased dramatically within the last 20 years, becoming one of the worst mosquito-borne human pathogens that tropical countries have to deal with. 2013 estimates indicate that as many as 390 million infections occur each year, and many dengue infections are increasingly understood to be
703:
This protease complex allows the inhibition of the production of type I interferon by reducing the activity of IFN-beta promoter; NS2B3 protease complex is involved in inhibiting the phosphorylation of IRF3. The NS2B3 protease complex inhibits (by cleaving) protein MITA which allows the IRF3
631:
Some people develop more severe forms of dengue, such as dengue hemorrhagic fever. Different strains of viruses interacting with people with different immune backgrounds lead to a complex interaction. Among the possible causes are cross-serotypic immune response, through a mechanism known as
492:
DENV NS4A is a nonstructural protein involved in altering cell membrane curvature and induction of autophagy. In addition to its membrane altering property, NS4A is a scaffold for the virus replication complex and undergoes oligomerization. Mutations of NS4A that affect interaction with NS4B
846:
The journal explores a novel approach by examining the potential of metal-TPI complexes (with iron, cobalt, and zinc) as inhibitors of dengue virus replication. Zn-TPI and Fe-TPI showed low toxicity and significant inhibition of DENV-3, while Co-TPI demonstrated antiviral activity at low
605:
Assembly occurs on intracellular membranes, which bud into the ER (forming the envelope from the ER membrane). Subsequent budding from the ER through the Golgi and into vesicles allows maturation via posttranslational modifications, e.g. glycosylation and pH transformational
223:
of the virus have been found, and a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. Nevertheless, the mainstream scientific community's understanding of dengue virus may be simplistic as, rather than distinct antigenic groups, a
2825:
Rouvinski A, Guardado-Calvo P, Barba-Spaeth G, Duquerroy S, Vaney MC, Kikuti CM, Navarro
Sanchez ME, Dejnirattisai W, Wongwiwat W, Haouz A, Girard-Blanc C, Petres S, Shepard WE, Desprès P, Arenzana-Seisdedos F, Dussart P, Mongkolsapaya J, Screaton GR, Rey FA (April 2015).
522:
The murine antibody 2H12 cross-reacts with all four DENV serotypes. It neutralizes the corresponding viruses, except DENV2. Its Fab fragment was crystallized in complex with the ED3 domains of DENV1, DENV3 and DENV4. Its epitope is located around the conserved AB loop of
673:
is a small, hydrophobic protein located in association with the endoplasmic reticulum. It may block the phosphorylation of STAT 1 after induction by interferons type I alpha & beta. In fact, as the activity of Tyk2 kinase decreases in association with
355:
from mosquito to mosquito has also been observed in some vector species. Dogs have been found to be infected by the virus, but more research is needed to determine if dogs or other animals can serve as reservoirs or are just incidental hosts.
589:
DENV undergoes endocytosis. Acidification of the endosome leads to a conformational change of E, exposing a fusion peptide sequence that facilitates fusion of the envelope with the endosomal membrane, releasing the virion capsid into the
729:
in the body. The mosquito's saliva was thought to make the virus spread faster due to the weakened immune response of its host. However, a current study has found that the protein D7 hinders the virus transmission into the host cells.
446:. Several molecules that interact with the viral E protein (ICAM3-grabbing nonintegrin, CD209, Rab 5, GRP 78, and the mannose receptor) have been shown to be important factors mediating attachment and viral entry. The membrane form of
2319:
Brandler S, Ruffie C, Najburg V, Frenkiel MP, Bedouelle H, Desprès P, Tangy F (September 2010). "Pediatric measles vaccine expressing a dengue tetravalent antigen elicits neutralizing antibodies against all four dengue viruses".
678:, so too does STAT 1 phosphorylation. Furthermore, the innate immune system's response to the virus is further damped as expression of interferon-stimulating gene(s) (ISG) is restricted by the aforementioned 'NS4B' protein.
769:, the immune system produces cross-reactive antibodies that provide immunity to that particular serotype. However, these antibodies are incapable of neutralizing other serotypes upon reinfection and actually increase
515:
The murine antibody E111 neutralizes DENV1. Its Fab and scFv fragments were crystallized in complex with the ED3 domain of DENV1. Its epitope is located around β-strands C and C' of ED3, and the intervening
3060:
Dejnirattisai W, Jumnainsong A, Onsirisakul N, Fitton P, Vasanawathana S, Limpitikul W, Puttikhunt C, Edwards C, Duangchinda T, Supasa S, Chawansuntati K, Malasit P, Mongkolsapaya J, Screaton G (May 2010).
1175:
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI (April 2013).
2827:
820:
There are no approved direct antiviral treatments for Dengue fever. Most antiviral drug research for Dengue infections has focussed on inhibition of the NS2B/NS3 protease or NS5 proteins. Reported
808:
In late 2015 and early 2016, the first dengue vaccine, Dengvaxia (CYD-TDV) by Sanofi-Pasteur, was registered in several countries for use in individuals 9–45 years of age living in endemic areas.
700:
NS2B3-b protease complex is a proteolytic core consisting of the last 40 amino acids of NS2B and the first 180 amino acids of NS3. Cleavage of the NS2B3 precursor activates the protease complex.
519:
The murine antibody 1A1D-2 strongly neutralizes DENV1, DENV2, and DENV3. Its Fab fragment was crystallized in complex with the ED3 domain of DENV2. Its epitope straddles β-strands A and G of ED3.
309:
mosquito and a colorized transmission electron micrograph of dengue virus particles (yellow/red). Photo by NIAID; micrograph courtesy of CDC; micrograph colorization and visual effects by NIAID.
527:
enabled one to analyze the roles of water molecules within the protein interfaces and the roles of somatic hypermutations outside of these interfaces in the interactions and cross-recognitions.
602:
As soon as functional RNA-dependent RNA polymerase is synthesized, RNA replication can commence. Synthesis is asymmetrical, making 10 times more of the positive-sense strand than the negative.
1933:
Tassaneetrithep B, Burgess TH, Granelli-Piperno A, Trumpfheller C, Finke J, Sun W, Eller MA, Pattanapanyasat K, Sarasombath S, Birx DL, Steinman RM, Schlesinger S, Marovich MA (April 2003).
530:
The chimpanzee antibody 5H2 potently neutralizes DENV4. Its Fab fragment was crystallized in complex with the sE protein of DENV4. Its epitope is included in domain 1 (ED1) of the E protein.
463:
The DENV prM (membrane) protein, which is important in the formation and maturation of the viral particle, consists of seven antiparallel β-strands stabilized by three disulfide bonds.
2733:
Lisova O, Belkadi L, Bedouelle H (April 2014). "Direct and indirect interactions in the recognition between a cross-neutralizing antibody and the four serotypes of dengue virus".
2553:
Lok SM, Kostyuchenko V, Nybakken GE, Holdaway HA, Battisti AJ, Sukupolvi-Petty S, Sedlak D, Fremont DH, Chipman PR, Roehrig JT, Diamond MS, Kuhn RJ, Rossmann MG (March 2008).
275:
10 per nucleotide per year, a rate similar to other RNA viruses. The
American African genotype has been estimated to have evolved between 1907 and 1949. This period includes
636:, which happens when a person who has been previously infected with dengue gets infected for the second, third, or fourth time. The previous antibodies to the old strain of
1401:"First isolation of Aedes flavivirus in the Western Hemisphere and evidence of vertical transmission in the mosquito Aedes (Stegomyia) albopictus (Diptera: Culicidae)"
438:
two glycosylation sites, and the peptide of fusion with the cellular membrane. ED3 is a continuous polypeptide segment; its fold is compact and immunoglobulin-like.
5430:
2602:
Midgley CM, Flanagan A, Tran HB, Dejnirattisai W, Chawansuntati K, Jumnainsong A, Wongwiwat W, Duangchinda T, Mongkolsapaya J, Grimes JM, Screaton GR (May 2012).
1886:"Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito cell-derived dengue viruses"
765:
serotype could possibly lead to severe dengue hemorrhagic shock when infected with another serotype due to antibody-dependent enhancement. When infected with
662:
has many nonstructural proteins that allow the inhibition of various mediators of the innate immune system response. These proteins act on two levels :
2229:"Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins"
283:, which were associated with considerable movement of populations and environmental disturbance, factors known to promote the evolution of new vector-borne
3960:
599:
Cellular and viral proteinases cleave the polypeptide into 10 proteins (E, M, C and 7 nonstructural/enzymatic proteins) while embedded on the ER membrane.
3457:"Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro"
2776:
Cockburn JJ, Navarro
Sanchez ME, Goncalvez AP, Zaitseva E, Stura EA, Kikuti CM, Duquerroy S, Dussart P, Chernomordik LV, Lai CJ, Rey FA (February 2012).
511:
the mature virion. The corresponding antibodies are, therefore, assumed to bind to alternate or transitional conformations of the virus at 37 °C.
4371:
799:
3942:
761:
approved in 11 countries (Mexico, the
Philippines, Indonesia, Brazil, El Salvador, Costa Rica, Paraguay, Guatemala, Peru, Thailand, and Singapore).
5186:
2692:
Cockburn JJ, Navarro
Sanchez ME, Fretes N, Urvoas A, Staropoli I, Kikuti CM, Coffey LL, Arenzana Seisdedos F, Bedouelle H, Rey FA (February 2012).
3208:"Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell"
5702:
3506:"Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex"
2653:"Mapping to completeness and transplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus"
347:, however, has followed its emergence from sylvatic cycles and the primary lifecycle now exclusively involves transmission between humans and
5715:
5440:
3974:"Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors"
2604:"Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity"
3972:
Leung, D.; Schroder, K.; White, H.; Fang, N. X.; Stoermer, M. J.; Abbenante, G.; Martin, J. L.; Young, P. R.; Fairlie, D. P. (2001-12-07).
1099:
4815:
3742:
2960:
493:
abolished or severely reduced virus replication indicating the importance of NS4A and its interaction with NS4B in dengue reproduction.
1289:
Costa RL, Voloch CM, Schrago CG (2012) Comparative evolutionary epidemiology of dengue virus serotypes. Infect Genet Evol 12(2):309-314
2357:"The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner"
3365:"Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation"
502:
The DENV RdRp is similar to other RdRps containing palm, finger, and thumb subdomains and a GDD motif for incorporating nucleotides.
2133:"The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors"
5753:
1008:
Dwivedi, V. D., Tripathi, I. P., Tripathi, R. C., Bharadwaj, S., & Mishra, S. K. (2017). Genomics, proteomics and evolution of
1299:
4452:
3827:
721:, which produces saliva that contains over 100 unique proteins, including the protein family D7. Scientists used to believe that
3843:
586:(DENV) E envelope protein binds to a cellular receptor. The exact nature of the cellular receptor has not been fully elucidated.
2945:
4364:
3875:
1742:
940:
2984:
267:
was reported. A single report of a fifth serotype DEN-5 in 2015 has not been replicated or further reported on. The rate of
4689:
2895:
1884:
Navarro-Sanchez E, Altmeyer R, Amara A, Schwartz O, Fieschi F, Virelizier JL, Arenzana-Seisdedos F, Desprès P (July 2003).
4804:
2280:"Thermodynamic stability of domain III from the envelope protein of flaviviruses and its improvement by molecular design"
1653:
Zakeri Z, Ghosh-Roy S, Datan E, McLean JE, Zandi K, Germain G (2015). "Cell death and virus infection – a short review".
3961:
https://www.fda.gov/news-events/press-announcements/first-fda-approved-vaccine-prevention-dengue-disease-endemic-regions
1552:"Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation"
963:
Normile D (October 2013). "Tropical medicine. Surprising new dengue virus throws a spanner in disease control efforts".
847:
concentrations. These findings suggest new possibilities for developing more effective antiviral treatments for dengue.
5748:
4098:"A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients"
2504:"Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope"
4679:
1029:
821:
4039:
Dražić, Tonko; Kopf, Sara; Corridan, James; Leuthold, Mila M.; Bertoša, Branimir; Klein, Christian D. (2020-01-09).
640:
now interfere with the immune response to the current strain, paradoxically leading to more virus entry and uptake.
5191:
5031:
4564:
4559:
4357:
4219:"The influence of metal on the performance of 2,4,5-triphenylimidazole as an inhibitor of dengue virus replication"
4196:"The influence of metal on the performance of 2,4,5-triphenylimidazole as an inhibitor of dengue virus replication"
39:
5720:
4041:"Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes"
3504:
Rodriguez-Madoz JR, Belicha-Villanueva A, Bernal-Rubio D, Ashour J, Ayllon J, Fernandez-Sesma A (October 2010).
843:
hepatitis C NS5 polymerase inhibitor, reached Phase II clinical trials but was stopped due to lack of efficacy.
359:
Recent findings suggest that as the virus infects human cells, host homeostatic processes such as autophagy and
4966:
2916:
839:
NS5 polymerase inhibitor progressed to a Phase II clinical trial before being stopped due to lack of efficacy.
633:
622:
2080:
Miller JL, de Wet BJ, deWet BJ, Martinez-Pomares L, Radcliffe CM, Dwek RA, Rudd PM, Gordon S (February 2008).
5223:
4863:
4462:
3717:
2502:
Austin SK, Dowd KA, Shrestha B, Nelson CA, Edeling MA, Johnson S, Pierson TC, Diamond MS, Fremont DH (2012).
812:
Dengue is endemic in the U.S. territories of
American Samoa, Guam, Puerto Rico, and the U.S. Virgin Islands.
2998:"Association of Allergic Symptoms with Dengue Infection and Severity: A Systematic Review and Meta-analysis"
5514:
5509:
5117:
3768:
825:
4261:
3893:"Preparing for dengue vaccine introduction: recommendations from the 1st dengue v2V International Meeting"
3611:
Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM (September 2016).
1550:
Datan E, Roy SG, Germain G, Zali N, McLean JE, Golshan G, Harbajan S, Lockshin RA, Zakeri Z (March 2016).
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Londono-Renteria BL, Shakeri H, Rozo-Lopez P, Conway MJ, Duggan N, Jaberi-Douraki M, Colpitts TM (2018).
2778:"Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus"
2182:"Development of Global Consensus of Dengue Virus Envelope Glycoprotein for Epitopes Based Vaccine Design"
1442:"First evidence of dengue infection in domestic dogs living in different ecological settings in Thailand"
397:
291:
1731:
1030:"A Putative Fifth Serotype of Dengue - Potential Implications for Diagnosis, Therapy and Vaccine Design"
5233:
5151:
5132:
4498:
2033:"Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2"
62:
4147:"Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir"
2961:
https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/Dengue-virus-disease?viewAsPdf=true
5356:
4819:
4711:
1235:"Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control"
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Holmes EC, Twiddy SS (May 2003). "The origin, emergence and evolutionary genetics of dengue virus".
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Jones M, Davidson A, Hibbert L, Gruenwald P, Schlaak J, Ball S, Foster GR, Jacobs M (May 2005).
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4854:
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4665:
4543:
4467:
4442:
4428:
4407:
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2996:
Kien ND, El-Qushayri AE, Ahmed AM, Safi A, Mageed SA, Mehyar SM, et al. (February 2020).
2693:
805:
In
September 2012, one of the vaccines was reported to not have done well in clinical trials.
534:
include the exposed side chains of the E fusion loop and the two conserved glycan side-chains.
5768:
5763:
5319:
5228:
5206:
4870:
4779:
4547:
4349:
3746:
3553:
Yu CY, Chang TH, Liang JJ, Chiang RL, Lee YL, Liao CL, Lin YL (June 2012). Diamond MS (ed.).
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Haddow AD, Guzman H, Popov VL, Wood TG, Widen SG, Haddow AD, Tesh RB, Weaver SC (June 2013).
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5758:
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3268:
3074:
2842:
1778:
1453:
1365:
1189:
972:
649:
447:
57:
4278:
2828:"Recognition determinants of broadly neutralizing human antibodies against dengue viruses"
596:
Host translational machinery (ribosomes) translates the (+)ssRNA into a single polypeptide
8:
5292:
5161:
4956:
3119:
2985:
https://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/dengue
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5504:
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4171:
4146:
4145:
Chen YL, Abdul Ghafar N, Karuna R, Fu Y, Lim SP, Schul W, et al. (February 2014).
4122:
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3663:
3639:
3612:
3581:
3554:
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3505:
3486:
3432:
3405:
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3315:
3237:
3183:
3158:
3095:
3062:
3022:
2997:
2874:
2802:
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2758:
2628:
2603:
2584:
2530:
2503:
2479:
2454:
2430:
2405:
2386:
2255:
2228:
2181:
2157:
2132:
2108:
2081:
2062:
2008:
1983:
1959:
1934:
1910:
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1861:
1836:
1706:
1681:
1630:
1603:
1576:
1551:
1527:
1500:
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1441:
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Halstead SB (January 1988). "Pathogenesis of dengue: challenges to molecular biology".
1307:
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Muñoz-Jordan JL, Sánchez-Burgos GG, Laurent-Rolle M, García-Sastre A (November 2003).
3206:
Ho LJ, Hung LF, Weng CY, Wu WL, Chou P, Lin YL, Chang DM, Tai TY, Lai JH (June 2005).
2197:
1982:
Krishnan MN, Sukumaran B, Pal U, Agaisse H, Murray JL, Hodge TW, Fikrig E (May 2007).
1801:
1766:
1334:
658:, has the ability to inhibit the innate immune response during the infection. Indeed,
5676:
5584:
5361:
4704:
4518:
4176:
4127:
4082:
4070:
4062:
4013:
4005:
3924:
3871:
3695:
3644:
3586:
3535:
3478:
3437:
3386:
3345:
3296:
3229:
3188:
3139:
3100:
3027:
2866:
2807:
2750:
2715:
2674:
2633:
2576:
2535:
2484:
2435:
2378:
2337:
2301:
2260:
2209:
2201:
2162:
2113:
2054:
2013:
1964:
1915:
1866:
1806:
1738:
1711:
1635:
1581:
1532:
1481:
1422:
1381:
1338:
1272:
1254:
1215:
1157:
1051:
988:
936:
900:
4096:
Nguyen NM, Tran CN, Phung LK, Duong KT, Huynh HA, Farrar J, et al. (May 2013).
4025:
3840:
3743:"Stellungnahme der STIKO zum neu-zugelassenen Lebendimpfstoff gegen Dengue (Qdenga)"
3490:
3254:
3241:
3174:
2390:
2066:
1046:
5681:
5312:
5297:
4927:
4738:
4733:
4166:
4158:
4117:
4109:
4052:
3995:
3985:
3959:
First FDA-approved vaccine for the prevention of dengue disease in endemic regions
3914:
3904:
3685:
3675:
3634:
3624:
3576:
3566:
3525:
3517:
3503:
3468:
3427:
3417:
3376:
3335:
3327:
3286:
3276:
3219:
3178:
3170:
3131:
3120:"Mechanisms of evasion of the type I interferon antiviral response by flaviviruses"
3090:
3082:
3017:
3009:
2878:
2858:
2850:
2797:
2789:
2762:
2742:
2705:
2664:
2623:
2615:
2566:
2525:
2515:
2474:
2466:
2425:
2417:
2368:
2329:
2291:
2250:
2240:
2193:
2152:
2144:
2103:
2093:
2044:
2003:
1995:
1954:
1946:
1905:
1897:
1856:
1848:
1796:
1786:
1701:
1693:
1662:
1625:
1615:
1571:
1563:
1522:
1512:
1471:
1461:
1412:
1373:
1330:
1262:
1246:
1205:
1197:
1147:
1137:
1041:
980:
912:
890:
882:
665:
389:
2333:
1932:
1124:
Vogels CB, Rückert C, Cavany SM, Perkins TA, Ebel GD, Grubaugh ND (January 2019).
5389:
5019:
5012:
5007:
4810:
4721:
4601:
4596:
4315:
4057:
4040:
3909:
3847:
3629:
3571:
3224:
3207:
2899:
2588:
2520:
2404:
Lee CM, Xie X, Zou J, Li SH, Lee MY, Dong H, Qin CF, Kang C, Shi PY (June 2015).
2098:
1466:
1142:
984:
550:
111:
4216:
4193:
2892:
2355:
Miller S, Kastner S, Krijnse-Locker J, Bühler S, Bartenschlager R (March 2007).
1666:
1417:
1400:
1250:
5216:
4904:
4875:
3555:"Dengue virus targets the adaptor protein MITA to subvert host innate immunity"
3261:
Proceedings of the
National Academy of Sciences of the United States of America
3159:"Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression"
3013:
2694:"Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody"
1771:
Proceedings of the National Academy of Sciences of the United States of America
1126:"Arbovirus coinfection and co-transmission: A neglected public health concern?"
777:
753:
747:
563:
393:
326:
318:
5271:
4273:
3D electron microscopy structures of dengue virus from the EM Data Bank (EMDB)
3865:
3861:
2710:
2049:
2032:
1901:
1852:
886:
505:
5737:
5652:
5563:
5473:
5421:
5342:
5324:
5246:
5166:
5042:
5024:
4936:
4726:
4383:
4066:
4009:
3680:
2619:
2296:
2279:
2245:
2205:
1697:
1258:
1055:
717:
571:
420:
401:
284:
99:
4113:
3473:
3456:
3281:
3086:
2824:
2453:
Zou J, Xie X, Wang QY, Dong H, Lee MY, Kang C, Yuan Z, Shi PY (April 2015).
1791:
1620:
1377:
5577:
5403:
5177:
4992:
4911:
4845:
4834:
4791:
4626:
4614:
4569:
4534:
4477:
4419:
4272:
4180:
4131:
4074:
4017:
3990:
3973:
3928:
3699:
3648:
3590:
3539:
3482:
3441:
3390:
3349:
3300:
3233:
3192:
3143:
3104:
3031:
2972:
2870:
2862:
2811:
2793:
2754:
2719:
2678:
2637:
2580:
2539:
2488:
2439:
2382:
2373:
2356:
2341:
2305:
2264:
2213:
2166:
2117:
2058:
2017:
1968:
1919:
1870:
1810:
1715:
1639:
1585:
1567:
1536:
1485:
1426:
1342:
1276:
1219:
1161:
992:
904:
626:
544:
467:
280:
209:
193:
147:
135:
123:
3135:
2669:
2652:
1984:"Rab 5 is required for the cellular entry of dengue and West Nile viruses"
1935:"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells"
1517:
1385:
756:
have been approved and are commercially available. On 5 December 2022 the
5661:
5408:
5398:
5302:
5283:
5110:
5105:
5001:
4980:
4765:
4699:
4656:
4586:
4508:
4432:
4387:
4218:
4195:
4162:
3521:
3331:
3059:
2470:
2421:
1999:
1950:
836:
832:
558:
276:
240:
4000:
2854:
2775:
2148:
1201:
871:"Dengue virus life cycle: viral and host factors modulating infectivity"
5595:
5525:
5495:
5445:
5329:
5211:
5092:
4947:
4825:
4756:
4638:
4487:
3661:
654:
In recent years, many studies have shown that flaviviruses, especially
610:
567:
377:
330:
268:
234:
215:
159:
42:
4302:
2571:
2554:
1100:"A Second Time Dengue Infection Can be Life-Threatening Says Research"
1013:
5604:
4396:
3850:, Dengue Vaccine Initiative, November 2012, accessed November 5, 2013
3497:
3422:
2746:
2278:
Zidane N, Dussart P, Bremand L, Villani ME, Bedouelle H (June 2013).
2131:
Zidane N, Ould-Abeih MB, Petit-Topin I, Bedouelle H (December 2012).
2082:"The mannose receptor mediates dengue virus infection of macrophages"
1680:
Neufeldt CJ, Cortese M, Acosta EG, Bartenschlager R (February 2018).
360:
260:
220:
87:
5623:
3862:"Ch. 54: Alphaviruses (Togaviridae) and Flaviviruses (Flaviviridae)"
3063:"Cross-reacting antibodies enhance dengue virus infection in humans"
2455:"Characterization of dengue virus NS4A and NS4B protein interaction"
2130:
1883:
1501:"Regulation of cell survival and death during Flavivirus infections"
380:
of positive-sense, single-stranded RNA (ssRNA) that codes for three
343:, with rare emergences into human populations. The global spread of
5646:
4380:
4337:
3610:
3381:
3364:
3313:
2944:
DISTRICT OF COLUMBIA DEPARTMENT OF HEALTH. Dengue Fever Factsheet.
2691:
1767:"A ligand-binding pocket in the dengue virus envelope glycoprotein"
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McLean JE, Wudzinska A, Datan E, Quaglino D, Zakeri Z (June 2011).
554:
264:
197:
3455:
Yusof R, Clum S, Wetzel M, Murthy HM, Padmanabhan R (April 2000).
1682:"Rewiring cellular networks by members of the Flaviviridae family"
1499:
Ghosh Roy S, Sadigh B, Datan E, Lockshin RA, Zakeri Z (May 2014).
1306:. Virginia Bioinformatics Institute, Virginia Tech. Archived from
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Dengue Guidelines for Diagnosis, Treatment, Prevention and Control
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3613:"Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection"
3363:
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2354:
2079:
770:
340:
3718:"World's first dengue fever vaccine launched in the Philippines"
3314:
Ashour J, Laurent-Rolle M, Shi PY, García-Sastre A (June 2009).
2601:
666:
Inhibition of interferon signaling by blocking signal transducer
400:(NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). It also includes short
5694:
5572:
5351:
5080:
5069:
2552:
695:
385:
373:
322:
294:
existed about 340 AD (95% confidence interval: 280 BC–850 AD).
290:
A Bayesian analysis of all four serotypes estimated that their
49:
4379:
3403:
3248:
2180:
Hussain, Mazhar; Idrees, Muhammad; Afzal, Samia (2015-07-22).
2030:
259:
Based on the analysis of the envelope protein, at least three
232:. Additionally, coinfection with and lack of rapid tests for
4217:
Sri Sumarsih; Muthia Dewi Pratiwi; Harsasi Setyawati (2020).
4194:
Sri Sumarsih; Muthia Dewi Pratiwi; Harsasi Setyawati (2020).
3606:
3604:
3602:
3600:
3156:
2318:
2226:
2024:
472:
409:
405:
335:
204:
74:
3316:"NS5 of dengue virus mediates STAT2 binding and degradation"
1601:
1498:
1034:
International Journal of Clinical & Medical Microbiology
868:
562:
most often during the rainy season in tropical countries in
228:
appears to exist. This same study identified 47 strains of
4643:
4223:
Asia Pacific Journal of Molecular Biology and Biotechnology
4200:
Asia Pacific Journal of Molecular Biology and Biotechnology
3943:"Sanofi Pasteur Dengue Vaccine Aces Second Phase III Trial"
3890:
2406:"Determinants of Dengue Virus NS4A Protein Oligomerization"
2277:
1981:
795:
506:
Complexes between the E protein and neutralizing antibodies
4038:
3597:
2971:
Centers for Disease Control and Prevention. Epidemiology.
2955:
2953:
2651:
Lisova O, Hardy F, Petit V, Bedouelle H (September 2007).
1764:
1652:
1123:
4279:"Brazil releases 'good' mosquitoes to fight dengue fever"
2650:
2227:
Zidane N, Dussart P, Bremand L, Bedouelle H (July 2013).
1233:
Mustafa, M. S.; Rasotgi, V.; Jain, S.; Gupta, V. (2015).
802:
Annual Meeting, held November 2–6, 2014, in New Orleans.
201:
30:
4144:
3362:
2995:
2501:
1174:
869:
Rodenhuis-Zybert IA, Wilschut J, Smit JM (August 2010).
271:
substitution for this virus has been estimated to be 6.5
3404:
Morrison J, Aguirre S, Fernandez-Sesma A (March 2012).
3307:
2950:
1765:
Modis Y, Ogata S, Clements D, Harrison SC (June 2003).
1232:
3971:
3655:
2732:
2031:
Jindadamrongwech S, Thepparit C, Smith DR (May 2004).
686:
cofactor may also take part in the STAT 1 inhibition.
3769:"Dengue vaccine: WHO position paper – September 2018"
3454:
1398:
4292:
4095:
3257:"Inhibition of interferon signaling by dengue virus"
2983:
Centers for Disease Control and Prevention. Dengue.
1439:
415:
3397:
1549:
1012:. Briefings in functional genomics.16(4): 217–227,
3802:"Sanofi's dengue vaccine approved in 11 countries"
3552:
2179:
1730:
1004:
1002:
725:saliva, when being transmitted, actually enhanced
3859:
800:American Society of Tropical Medicine and Hygiene
5735:
3664:"Aedes aegypti D7 Salivary Proteins in Colombia"
1062:
442:is transmitted by species of the mosquito genus
3356:
1926:
1027:
999:
3891:Torresi J, Tapia-Conyer R, Margolis H (2013).
2452:
1178:"The global distribution and burden of dengue"
4365:
3828:"Dengue Fever Vaccine Available in Indonesia"
3448:
3124:Journal of Interferon & Cytokine Research
2940:
2938:
2893:http://www.austincc.edu/microbio/2993p/df.htm
1597:
1595:
1440:Thongyuan S, Kittayapong P (30 August 2017).
707:
244:complicate matters in real-world infections.
3205:
1728:
1320:
781:
696:Inhibition of the type I interferon response
643:
4816:Severe fever with thrombocytopenia syndrome
3794:
3546:
2911:
2909:
2907:
2403:
2284:Protein Engineering, Design & Selection
52:(the cluster of dark dots near the center)
4372:
4358:
3761:
3047:Fundamentals of Molecular Virology, 2nd ed
2935:
1834:
1592:
958:
956:
954:
952:
29:
4170:
4121:
4056:
3999:
3989:
3918:
3908:
3689:
3679:
3638:
3628:
3580:
3570:
3529:
3472:
3431:
3421:
3406:"Innate immunity evasion by Dengue virus"
3380:
3339:
3290:
3280:
3223:
3182:
3094:
3021:
2801:
2709:
2668:
2627:
2570:
2559:Nature Structural & Molecular Biology
2529:
2519:
2478:
2429:
2372:
2295:
2254:
2244:
2156:
2107:
2097:
2048:
2007:
1958:
1909:
1860:
1830:
1828:
1826:
1824:
1822:
1820:
1800:
1790:
1705:
1629:
1619:
1575:
1526:
1516:
1475:
1465:
1416:
1283:
1266:
1209:
1151:
1141:
1045:
1028:Taylor-Robinson, Andrew W. (2016-03-03).
894:
577:
455:and as immunogens in vaccine candidates.
3820:
3737:
3735:
2973:https://www.cdc.gov/dengue/epidemiology/
2904:
1975:
1722:
1355:
864:
862:
860:
419:
301:
3117:
3044:
1877:
1837:"Structural proteomics of dengue virus"
962:
949:
715:is transmitted by the mosquito species
5736:
4283:BBC News Latin America & Caribbean
2073:
1817:
549:Common names for dengue fever include
263:(1 to 3) are known. In 2013, a fourth
5628:
5627:
5187:Hemorrhagic fever with renal syndrome
4353:
3732:
3711:
3709:
2959:Better Health. Dengue virus disease.
1505:World Journal of Biological Chemistry
1292:
919:
857:
3715:
1939:The Journal of Experimental Medicine
1106:. United Kingdom. September 18, 2015
1023:
1021:
875:Cellular and Molecular Life Sciences
4690:Venezuelan equine encephalomyelitis
3978:The Journal of Biological Chemistry
3461:The Journal of Biological Chemistry
2361:The Journal of Biological Chemistry
1729:Hanley KA, Weaver SC, eds. (2010).
1608:The Journal of Biological Chemistry
1239:Medical Journal, Armed Forces India
1014:https://doi.org/10.1093/bfgp/elw040
925:
824:approaches have focussed mainly on
780:started building a new facility in
741:
13:
4102:The Journal of Infectious Diseases
3706:
3369:The Journal of Infectious Diseases
2186:Current Computer-Aided Drug Design
1733:Frontiers in Dengue Virus Research
14:
5780:
4237:
3860:Schmaljohn AL, McClain D (1996).
2198:10.2174/1573409911666150529130134
1835:Perera R, Kuhn RJ (August 2008).
1323:Infection, Genetics and Evolution
1018:
616:
593:Uncoating occurs in the cytoplasm
416:Structural and enzymatic proteins
200:-borne, single positive-stranded
4680:Western equine encephalomyelitis
4670:Eastern equine encephalomyelitis
4244:
3897:PLOS Neglected Tropical Diseases
3617:PLOS Neglected Tropical Diseases
2891:Wiatrek, Melissa. Dengue Fever.
2735:Journal of Molecular Recognition
1737:. Caister Academic. p. 13.
815:
458:
333:between mosquitoes of the genus
61:
5754:Human viruses described in 1907
4805:Crimean–Congo hemorrhagic fever
4210:
4187:
4138:
4089:
4032:
3965:
3953:
3935:
3884:
3853:
3834:
3199:
3175:10.1128/JVI.79.9.5414-5420.2005
3150:
3111:
3053:
3038:
2989:
2977:
2965:
2921:World Health Organization (WHO)
2885:
2818:
2769:
2726:
2685:
2657:The Journal of General Virology
2644:
2595:
2546:
2495:
2446:
2397:
2348:
2312:
2271:
2220:
2173:
2124:
1841:Current Opinion in Microbiology
1758:
1673:
1646:
1543:
1492:
1433:
1392:
1349:
1314:
1304:Pathogen Information (PathInfo)
1226:
487:
313:Until a few hundred years ago,
4967:Kemerovo tickborne viral fever
4045:Journal of Medicinal Chemistry
3782:(93): 457–76. 7 September 2018
1168:
1117:
1092:
634:antibody-dependent enhancement
623:Antibody-dependent enhancement
496:
478:
1:
5224:Hantavirus pulmonary syndrome
4463:Jamestown Canyon encephalitis
3776:Weekly Epidemiological Record
3118:Diamond MS (September 2009).
3045:Acheson, Nicholas H. (2011).
2334:10.1016/j.vaccine.2010.07.073
1335:10.1016/s1567-1348(03)00004-2
935:. World Health Organization.
850:
428:showing structural components
251:asymptomatic or subclinical.
5118:Venezuelan hemorrhagic fever
4058:10.1021/acs.jmedchem.9b00759
3910:10.1371/journal.pntd.0002261
3716:East, Susie (6 April 2016).
3630:10.1371/journal.pntd.0004941
3572:10.1371/journal.ppat.1002780
3225:10.4049/jimmunol.174.12.8163
2521:10.1371/journal.ppat.1002930
2099:10.1371/journal.ppat.0040017
1686:Nature Reviews. Microbiology
1467:10.1371/journal.pone.0180013
1143:10.1371/journal.pbio.3000130
985:10.1126/science.342.6157.415
826:targeted covalent inhibitors
432:
297:
254:
7:
5140:Brazilian hemorrhagic fever
5128:Argentine hemorrhagic fever
1667:10.13140/RG.2.2.35359.97447
1418:10.1016/j.virol.2012.12.008
1251:10.1016/j.mjafi.2014.09.011
1047:10.15344/2456-4028/2016/101
364:different research groups.
292:most recent common ancestor
10:
5785:
5152:Bolivian hemorrhagic fever
5032:Sandfly fever Naples virus
3668:Frontiers in Public Health
3014:10.1007/s12250-019-00165-6
2917:"Dengue and severe dengue"
745:
708:Mosquito D7 saliva protein
647:
620:
542:
538:
5749:Viruses described in 1907
5636:
5593:
5561:
5552:
5523:
5493:
5471:
5460:
5419:
5387:
5340:
5281:
5270:
5244:
5175:
5090:
5079:
5068:
5040:
4990:
4979:
4945:
4925:
4843:
4820:Huaiyangshan banyangvirus
4789:
4778:
4754:
4654:
4532:
4417:
4406:
4395:
4325:
4296:
2711:10.1016/j.str.2012.01.001
2050:10.1007/s00705-003-0263-x
1902:10.1038/sj.embor.embor866
1853:10.1016/j.mib.2008.06.004
887:10.1007/s00018-010-0357-z
758:European Medicines Agency
644:Immune system interaction
367:
56:
37:
28:
21:
5436:SARS-related coronavirus
5399:Henipavirus encephalitis
5257:Murid gammaherpesvirus 4
5102:Viral hemorrhagic fevers
4883:Viral hemorrhagic fevers
4855:Arbovirus encephalitides
4831:Arbovirus encephalitides
4801:Viral hemorrhagic fevers
4766:Banna virus encephalitis
4666:Arbovirus encephalitides
4611:Viral hemorrhagic fevers
4577:Saint Louis encephalitis
4544:Arbovirus encephalitides
4495:Viral hemorrhagic fevers
4429:Arbovirus encephalitides
3681:10.3389/fpubh.2018.00111
2620:10.4049/jimmunol.1200227
2246:10.1186/1471-2334-13-302
1698:10.1038/nrmicro.2017.170
1556:Cell Death & Disease
1070:"A new understanding of
5540:Yaba monkey tumor virus
4897:Kyasanur Forest disease
4859:Tick-borne encephalitis
4560:Australian encephalitis
4453:California encephalitis
3474:10.1074/jbc.275.14.9963
3282:10.1073/pnas.2335168100
3087:10.1126/science.1185181
2233:BMC Infectious Diseases
1792:10.1073/pnas.0832193100
1621:10.1074/jbc.M110.192500
1378:10.1126/science.3277268
4887:Omsk hemorrhagic fever
4468:La Crosse encephalitis
3991:10.1074/jbc.M107360200
2794:10.1038/emboj.2011.439
2374:10.1074/jbc.M609919200
2297:10.1093/protein/gzt010
1655:20 Years of Cell Death
1568:10.1038/cddis.2015.409
782:
578:Mechanism of infection
429:
398:nonstructural proteins
310:
5320:Marburg virus disease
4871:Powassan encephalitis
4548:Japanese encephalitis
4114:10.1093/infdis/jis470
3747:Robert Koch Institute
3212:Journal of Immunology
3136:10.1089/jir.2009.0069
2670:10.1099/vir.0.83028-0
2608:Journal of Immunology
1518:10.4331/wjbc.v5.i2.93
648:Further information:
621:Further information:
423:
353:Vertical transmission
305:
4746:Semliki Forest virus
4285:. 24 September 2014.
4163:10.1128/JVI.02841-13
3867:Medical Microbiology
3864:. In Baron S (ed.).
3522:10.1128/JVI.01051-10
3332:10.1128/JVI.02188-08
2471:10.1128/JVI.03453-14
2422:10.1128/JVI.00546-15
2037:Archives of Virology
2000:10.1128/JVI.02210-06
1951:10.1084/jem.20021840
1080:. September 18, 2015
650:Innate immune system
448:ribosomal protein SA
404:regions on both the
58:Virus classification
5293:Ebola virus disease
4957:Colorado tick fever
4712:O'nyong'nyong fever
4151:Journal of Virology
3984:(49): 45762–45771.
3947:GEN News Highlights
3841:Vaccine Development
3830:. October 17, 2016.
3510:Journal of Virology
3320:Journal of Virology
3273:2003PNAS..10014333M
3163:Journal of Virology
3079:2010Sci...328..745D
2855:10.1038/nature14130
2847:2015Natur.520..109R
2459:Journal of Virology
2410:Journal of Virology
2149:10.1042/BSR20120103
1988:Journal of Virology
1783:2003PNAS..100.6986M
1458:2017PLoSO..1280013T
1370:1988Sci...239..476H
1202:10.1038/nature12060
1194:2013Natur.496..504B
977:2013Sci...342..415N
424:Cross section of a
382:structural proteins
317:was transmitted in
5505:Simian foamy virus
4326:External resources
3846:2019-08-21 at the
3749:. 15 February 2023
2898:2018-07-26 at the
2137:Bioscience Reports
822:protease inhibitor
783:Neuville-sur-Saône
609:Egress occurs via
430:
311:
192:) is the cause of
5731:
5730:
5630:Taxon identifiers
5621:
5620:
5617:
5616:
5613:
5612:
5548:
5547:
5456:
5455:
5266:
5265:
5064:
5063:
5060:
5059:
4975:
4974:
4774:
4773:
4519:Rift Valley fever
4347:
4346:
3877:978-0-9631172-1-2
3002:Virologica Sinica
2663:(Pt 9): 2387–97.
2572:10.1038/nsmb.1382
1744:978-1-904455-50-9
942:978-92-4-154787-1
793:
771:viral replication
451:directed against
181:
180:
5776:
5724:
5723:
5711:
5710:
5698:
5697:
5685:
5684:
5672:
5671:
5670:
5657:
5656:
5655:
5625:
5624:
5559:
5558:
5469:
5468:
5279:
5278:
5088:
5087:
5077:
5076:
5052:Chandipura virus
4988:
4987:
4928:Orthomyxoviridae
4787:
4786:
4734:Ross River fever
4499:Bunyamwera fever
4415:
4414:
4404:
4403:
4374:
4367:
4360:
4351:
4350:
4294:
4293:
4286:
4248:
4247:
4231:
4230:
4214:
4208:
4207:
4191:
4185:
4184:
4174:
4142:
4136:
4135:
4125:
4093:
4087:
4086:
4060:
4036:
4030:
4029:
4003:
3993:
3969:
3963:
3957:
3951:
3950:
3939:
3933:
3932:
3922:
3912:
3888:
3882:
3881:
3857:
3851:
3838:
3832:
3831:
3824:
3818:
3817:
3815:
3813:
3798:
3792:
3791:
3789:
3787:
3773:
3765:
3759:
3758:
3756:
3754:
3739:
3730:
3729:
3727:
3725:
3713:
3704:
3703:
3693:
3683:
3659:
3653:
3652:
3642:
3632:
3608:
3595:
3594:
3584:
3574:
3550:
3544:
3543:
3533:
3501:
3495:
3494:
3476:
3452:
3446:
3445:
3435:
3425:
3423:10.3390/v4030397
3401:
3395:
3394:
3384:
3360:
3354:
3353:
3343:
3311:
3305:
3304:
3294:
3284:
3252:
3246:
3245:
3227:
3203:
3197:
3196:
3186:
3154:
3148:
3147:
3115:
3109:
3108:
3098:
3057:
3051:
3050:
3042:
3036:
3035:
3025:
2993:
2987:
2981:
2975:
2969:
2963:
2957:
2948:
2942:
2933:
2932:
2930:
2928:
2913:
2902:
2889:
2883:
2882:
2841:(7545): 109–13.
2832:
2822:
2816:
2815:
2805:
2782:The EMBO Journal
2773:
2767:
2766:
2747:10.1002/jmr.2352
2730:
2724:
2723:
2713:
2689:
2683:
2682:
2672:
2648:
2642:
2641:
2631:
2599:
2593:
2592:
2574:
2550:
2544:
2543:
2533:
2523:
2514:(10): e1002930.
2499:
2493:
2492:
2482:
2450:
2444:
2443:
2433:
2401:
2395:
2394:
2376:
2352:
2346:
2345:
2316:
2310:
2309:
2299:
2275:
2269:
2268:
2258:
2248:
2224:
2218:
2217:
2177:
2171:
2170:
2160:
2128:
2122:
2121:
2111:
2101:
2077:
2071:
2070:
2052:
2028:
2022:
2021:
2011:
1979:
1973:
1972:
1962:
1930:
1924:
1923:
1913:
1881:
1875:
1874:
1864:
1832:
1815:
1814:
1804:
1794:
1762:
1756:
1755:
1753:
1751:
1736:
1726:
1720:
1719:
1709:
1677:
1671:
1670:
1650:
1644:
1643:
1633:
1623:
1614:(25): 22147–59.
1599:
1590:
1589:
1579:
1562:(e2127): e2127.
1547:
1541:
1540:
1530:
1520:
1496:
1490:
1489:
1479:
1469:
1437:
1431:
1430:
1420:
1396:
1390:
1389:
1364:(4839): 476–81.
1353:
1347:
1346:
1318:
1312:
1311:
1296:
1290:
1287:
1281:
1280:
1270:
1230:
1224:
1223:
1213:
1172:
1166:
1165:
1155:
1145:
1121:
1115:
1114:
1112:
1111:
1096:
1090:
1089:
1087:
1085:
1066:
1060:
1059:
1049:
1025:
1016:
1006:
997:
996:
960:
947:
946:
934:
923:
917:
916:
898:
866:
787:
785:
742:Vaccine research
394:envelope protein
390:membrane protein
274:
66:
65:
33:
19:
18:
16:Species of virus
5784:
5783:
5779:
5778:
5777:
5775:
5774:
5773:
5734:
5733:
5732:
5727:
5719:
5714:
5706:
5701:
5693:
5688:
5680:
5675:
5666:
5665:
5660:
5651:
5650:
5645:
5632:
5622:
5609:
5589:
5554:
5544:
5519:
5489:
5463:
5452:
5415:
5390:Paramyxoviridae
5383:
5336:
5273:
5262:
5240:
5171:
5082:
5071:
5056:
5036:
5020:Pappataci fever
5013:Oropouche virus
5008:Oropouche fever
4982:
4971:
4941:
4921:
4839:
4811:Heartland virus
4781:
4770:
4750:
4722:Pogosta disease
4650:
4597:West Nile fever
4528:
4409:
4398:
4391:
4378:
4348:
4343:
4342:
4321:
4320:
4305:
4290:
4277:
4269:
4268:
4267:
4249:
4245:
4240:
4235:
4234:
4215:
4211:
4192:
4188:
4143:
4139:
4094:
4090:
4037:
4033:
3970:
3966:
3958:
3954:
3941:
3940:
3936:
3889:
3885:
3878:
3858:
3854:
3848:Wayback Machine
3839:
3835:
3826:
3825:
3821:
3811:
3809:
3800:
3799:
3795:
3785:
3783:
3771:
3767:
3766:
3762:
3752:
3750:
3741:
3740:
3733:
3723:
3721:
3714:
3707:
3660:
3656:
3623:(9): e0004941.
3609:
3598:
3565:(6): e1002780.
3551:
3547:
3516:(19): 9760–74.
3502:
3498:
3453:
3449:
3402:
3398:
3361:
3357:
3326:(11): 5408–18.
3312:
3308:
3267:(24): 14333–8.
3253:
3249:
3218:(12): 8163–72.
3204:
3200:
3155:
3151:
3116:
3112:
3073:(5979): 745–8.
3058:
3054:
3043:
3039:
2994:
2990:
2982:
2978:
2970:
2966:
2958:
2951:
2943:
2936:
2926:
2924:
2923:. 17 March 2023
2915:
2914:
2905:
2900:Wayback Machine
2890:
2886:
2830:
2823:
2819:
2774:
2770:
2731:
2727:
2690:
2686:
2649:
2645:
2600:
2596:
2551:
2547:
2500:
2496:
2451:
2447:
2416:(12): 6171–83.
2402:
2398:
2367:(12): 8873–82.
2353:
2349:
2317:
2313:
2276:
2272:
2225:
2221:
2178:
2174:
2129:
2125:
2078:
2074:
2029:
2025:
1980:
1976:
1931:
1927:
1882:
1878:
1833:
1818:
1777:(12): 6986–91.
1763:
1759:
1749:
1747:
1745:
1727:
1723:
1678:
1674:
1651:
1647:
1600:
1593:
1548:
1544:
1497:
1493:
1452:(8): e0180013.
1438:
1434:
1397:
1393:
1354:
1350:
1319:
1315:
1298:
1297:
1293:
1288:
1284:
1231:
1227:
1188:(7446): 504–7.
1173:
1169:
1136:(1): e3000130.
1122:
1118:
1109:
1107:
1098:
1097:
1093:
1083:
1081:
1068:
1067:
1063:
1026:
1019:
1007:
1000:
961:
950:
943:
932:
924:
920:
881:(16): 2773–86.
867:
858:
853:
835:, a repurposed
818:
750:
744:
710:
698:
668:
652:
646:
629:
619:
580:
551:breakbone fever
547:
541:
508:
499:
490:
481:
461:
435:
418:
376:is about 11000
370:
319:sylvatic cycles
300:
272:
257:
177:
137:Amarillovirales
113:Kitrinoviricota
60:
17:
12:
11:
5:
5782:
5772:
5771:
5766:
5761:
5756:
5751:
5746:
5729:
5728:
5726:
5725:
5712:
5699:
5686:
5673:
5658:
5642:
5640:
5634:
5633:
5619:
5618:
5615:
5614:
5611:
5610:
5608:
5607:
5601:
5599:
5591:
5590:
5588:
5587:
5582:
5581:
5580:
5569:
5567:
5556:
5550:
5549:
5546:
5545:
5543:
5542:
5537:
5531:
5529:
5521:
5520:
5518:
5517:
5512:
5507:
5501:
5499:
5491:
5490:
5488:
5487:
5479:
5477:
5466:
5458:
5457:
5454:
5453:
5451:
5450:
5449:
5448:
5443:
5433:
5427:
5425:
5417:
5416:
5414:
5413:
5412:
5411:
5406:
5395:
5393:
5385:
5384:
5382:
5381:
5376:
5375:
5374:
5369:
5364:
5359:
5348:
5346:
5338:
5337:
5335:
5334:
5333:
5332:
5327:
5317:
5316:
5315:
5310:
5305:
5300:
5289:
5287:
5276:
5268:
5267:
5264:
5263:
5261:
5260:
5252:
5250:
5242:
5241:
5239:
5238:
5237:
5236:
5231:
5221:
5220:
5219:
5214:
5209:
5204:
5199:
5194:
5183:
5181:
5173:
5172:
5170:
5169:
5164:
5159:
5158:
5157:
5149:
5148:
5147:
5137:
5136:
5135:
5125:
5124:
5123:
5115:
5114:
5113:
5098:
5096:
5085:
5074:
5066:
5065:
5062:
5061:
5058:
5057:
5055:
5054:
5048:
5046:
5038:
5037:
5035:
5034:
5029:
5028:
5027:
5017:
5016:
5015:
5005:
4998:
4996:
4985:
4977:
4976:
4973:
4972:
4970:
4969:
4964:
4963:
4962:
4953:
4951:
4943:
4942:
4940:
4939:
4933:
4931:
4923:
4922:
4920:
4919:
4918:
4917:
4909:
4908:
4907:
4902:
4894:
4893:
4892:
4880:
4879:
4878:
4868:
4867:
4866:
4851:
4849:
4841:
4840:
4838:
4837:
4828:
4823:
4813:
4808:
4797:
4795:
4784:
4776:
4775:
4772:
4771:
4769:
4768:
4762:
4760:
4752:
4751:
4749:
4748:
4743:
4742:
4741:
4731:
4730:
4729:
4719:
4718:
4717:
4709:
4708:
4707:
4697:
4696:
4695:
4687:
4686:
4685:
4677:
4676:
4675:
4662:
4660:
4652:
4651:
4649:
4648:
4647:
4646:
4636:
4635:
4634:
4624:
4623:
4622:
4607:
4606:
4605:
4604:
4594:
4593:
4592:
4584:
4583:
4582:
4574:
4573:
4572:
4567:
4557:
4556:
4555:
4540:
4538:
4530:
4529:
4527:
4526:
4525:
4524:
4516:
4515:
4514:
4506:
4505:
4504:
4491:
4490:
4485:
4484:
4483:
4475:
4474:
4473:
4465:
4460:
4459:
4458:
4450:
4449:
4448:
4440:
4439:
4438:
4425:
4423:
4412:
4401:
4393:
4392:
4384:viral diseases
4377:
4376:
4369:
4362:
4354:
4345:
4344:
4341:
4340:
4330:
4329:
4327:
4323:
4322:
4319:
4318:
4306:
4301:
4300:
4298:
4297:Classification
4288:
4287:
4275:
4250:
4243:
4242:
4241:
4239:
4238:External links
4236:
4233:
4232:
4209:
4186:
4137:
4108:(9): 1442–50.
4088:
4051:(1): 140–156.
4031:
3964:
3952:
3934:
3883:
3876:
3852:
3833:
3819:
3793:
3760:
3731:
3705:
3654:
3596:
3559:PLOS Pathogens
3545:
3496:
3467:(14): 9963–9.
3447:
3416:(3): 397–413.
3396:
3382:10.1086/605847
3375:(8): 1261–70.
3355:
3306:
3247:
3198:
3169:(9): 5414–20.
3149:
3110:
3052:
3037:
2988:
2976:
2964:
2949:
2934:
2903:
2884:
2817:
2768:
2725:
2684:
2643:
2614:(10): 4971–9.
2594:
2545:
2508:PLOS Pathogens
2494:
2465:(7): 3455–70.
2445:
2396:
2347:
2328:(41): 6730–9.
2311:
2270:
2219:
2172:
2123:
2086:PLOS Pathogens
2072:
2023:
1974:
1925:
1876:
1816:
1757:
1743:
1721:
1692:(3): 125–142.
1672:
1661:(1): 292–325.
1645:
1591:
1542:
1491:
1432:
1391:
1348:
1313:
1310:on 2010-08-30.
1300:"Dengue virus"
1291:
1282:
1225:
1167:
1116:
1091:
1061:
1017:
998:
948:
941:
918:
855:
854:
852:
849:
817:
814:
794:, a suburb of
778:Sanofi-Pasteur
754:dengue vaccine
748:Dengue vaccine
746:Main article:
743:
740:
709:
706:
697:
694:
667:
664:
645:
642:
618:
617:Severe disease
615:
614:
613:
607:
606:rearrangements
603:
600:
597:
594:
591:
587:
579:
576:
564:Southeast Asia
543:Main article:
540:
537:
536:
535:
531:
528:
524:
520:
517:
507:
504:
498:
495:
489:
486:
480:
477:
460:
457:
434:
431:
417:
414:
369:
366:
327:Southeast Asia
299:
296:
256:
253:
207:of the family
179:
178:
171:
169:
165:
164:
157:
153:
152:
145:
141:
140:
133:
129:
128:
125:Flasuviricetes
121:
117:
116:
109:
105:
104:
97:
93:
92:
85:
78:
77:
72:
68:
67:
54:
53:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
5781:
5770:
5767:
5765:
5762:
5760:
5757:
5755:
5752:
5750:
5747:
5745:
5744:Human viruses
5742:
5741:
5739:
5722:
5717:
5713:
5709:
5704:
5700:
5696:
5691:
5687:
5683:
5678:
5674:
5669:
5663:
5659:
5654:
5648:
5644:
5643:
5641:
5639:
5635:
5631:
5626:
5606:
5603:
5602:
5600:
5598:
5597:
5592:
5586:
5583:
5579:
5576:
5575:
5574:
5571:
5570:
5568:
5566:
5565:
5564:Rhabdoviridae
5560:
5557:
5551:
5541:
5538:
5536:
5533:
5532:
5530:
5528:
5527:
5522:
5516:
5513:
5511:
5508:
5506:
5503:
5502:
5500:
5498:
5497:
5492:
5486:
5485:
5481:
5480:
5478:
5476:
5475:
5474:Herpesviridae
5470:
5467:
5465:
5459:
5447:
5444:
5442:
5439:
5438:
5437:
5434:
5432:
5429:
5428:
5426:
5424:
5423:
5422:Coronaviridae
5418:
5410:
5407:
5405:
5402:
5401:
5400:
5397:
5396:
5394:
5392:
5391:
5386:
5380:
5377:
5373:
5370:
5368:
5365:
5363:
5360:
5358:
5355:
5354:
5353:
5350:
5349:
5347:
5345:
5344:
5343:Rhabdoviridae
5339:
5331:
5328:
5326:
5323:
5322:
5321:
5318:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5295:
5294:
5291:
5290:
5288:
5286:
5285:
5280:
5277:
5275:
5269:
5259:
5258:
5254:
5253:
5251:
5249:
5248:
5247:Herpesviridae
5243:
5235:
5232:
5230:
5227:
5226:
5225:
5222:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5189:
5188:
5185:
5184:
5182:
5180:
5179:
5174:
5168:
5165:
5163:
5160:
5155:
5154:
5153:
5150:
5146:
5143:
5142:
5141:
5138:
5134:
5131:
5130:
5129:
5126:
5121:
5120:
5119:
5116:
5112:
5109:
5108:
5107:
5103:
5100:
5099:
5097:
5095:
5094:
5089:
5086:
5084:
5078:
5075:
5073:
5067:
5053:
5050:
5049:
5047:
5045:
5044:
5043:Rhabdoviridae
5039:
5033:
5030:
5026:
5025:Toscana virus
5023:
5022:
5021:
5018:
5014:
5011:
5010:
5009:
5006:
5003:
5000:
4999:
4997:
4995:
4994:
4989:
4986:
4984:
4978:
4968:
4965:
4960:
4959:
4958:
4955:
4954:
4952:
4950:
4949:
4944:
4938:
4937:Bourbon virus
4935:
4934:
4932:
4930:
4929:
4924:
4915:
4914:
4913:
4910:
4906:
4903:
4900:
4899:
4898:
4895:
4890:
4889:
4888:
4884:
4881:
4877:
4874:
4873:
4872:
4869:
4865:
4862:
4861:
4860:
4856:
4853:
4852:
4850:
4848:
4847:
4842:
4836:
4832:
4829:
4827:
4824:
4821:
4817:
4814:
4812:
4809:
4806:
4802:
4799:
4798:
4796:
4794:
4793:
4788:
4785:
4783:
4777:
4767:
4764:
4763:
4761:
4759:
4758:
4753:
4747:
4744:
4740:
4737:
4736:
4735:
4732:
4728:
4727:Sindbis virus
4725:
4724:
4723:
4720:
4715:
4714:
4713:
4710:
4706:
4703:
4702:
4701:
4698:
4693:
4692:
4691:
4688:
4683:
4682:
4681:
4678:
4673:
4672:
4671:
4667:
4664:
4663:
4661:
4659:
4658:
4653:
4645:
4642:
4641:
4640:
4637:
4633:
4630:
4629:
4628:
4625:
4621:
4618:
4617:
4616:
4612:
4609:
4608:
4603:
4600:
4599:
4598:
4595:
4590:
4589:
4588:
4585:
4580:
4579:
4578:
4575:
4571:
4568:
4566:
4563:
4562:
4561:
4558:
4554:
4551:
4550:
4549:
4545:
4542:
4541:
4539:
4537:
4536:
4531:
4522:
4521:
4520:
4517:
4512:
4511:
4510:
4507:
4502:
4501:
4500:
4496:
4493:
4492:
4489:
4486:
4481:
4480:
4479:
4476:
4471:
4470:
4469:
4466:
4464:
4461:
4456:
4455:
4454:
4451:
4446:
4445:
4444:
4441:
4436:
4435:
4434:
4430:
4427:
4426:
4424:
4422:
4421:
4416:
4413:
4411:
4405:
4402:
4400:
4394:
4389:
4385:
4382:
4375:
4370:
4368:
4363:
4361:
4356:
4355:
4352:
4339:
4335:
4332:
4331:
4328:
4324:
4317:
4313:
4312:
4308:
4307:
4304:
4299:
4295:
4291:
4284:
4280:
4276:
4274:
4271:
4270:
4265:
4264:
4263:
4257:
4253:
4229:(3): 113–121.
4228:
4224:
4220:
4213:
4206:(3): 113–121.
4205:
4201:
4197:
4190:
4182:
4178:
4173:
4168:
4164:
4160:
4157:(3): 1740–7.
4156:
4152:
4148:
4141:
4133:
4129:
4124:
4119:
4115:
4111:
4107:
4103:
4099:
4092:
4084:
4080:
4076:
4072:
4068:
4064:
4059:
4054:
4050:
4046:
4042:
4035:
4027:
4023:
4019:
4015:
4011:
4007:
4002:
3997:
3992:
3987:
3983:
3979:
3975:
3968:
3962:
3956:
3948:
3944:
3938:
3930:
3926:
3921:
3916:
3911:
3906:
3902:
3898:
3894:
3887:
3879:
3873:
3869:
3868:
3863:
3856:
3849:
3845:
3842:
3837:
3829:
3823:
3807:
3803:
3797:
3781:
3777:
3770:
3764:
3748:
3745:(in German).
3744:
3738:
3736:
3719:
3712:
3710:
3701:
3697:
3692:
3687:
3682:
3677:
3673:
3669:
3665:
3658:
3650:
3646:
3641:
3636:
3631:
3626:
3622:
3618:
3614:
3607:
3605:
3603:
3601:
3592:
3588:
3583:
3578:
3573:
3568:
3564:
3560:
3556:
3549:
3541:
3537:
3532:
3527:
3523:
3519:
3515:
3511:
3507:
3500:
3492:
3488:
3484:
3480:
3475:
3470:
3466:
3462:
3458:
3451:
3443:
3439:
3434:
3429:
3424:
3419:
3415:
3411:
3407:
3400:
3392:
3388:
3383:
3378:
3374:
3370:
3366:
3359:
3351:
3347:
3342:
3337:
3333:
3329:
3325:
3321:
3317:
3310:
3302:
3298:
3293:
3288:
3283:
3278:
3274:
3270:
3266:
3262:
3258:
3251:
3243:
3239:
3235:
3231:
3226:
3221:
3217:
3213:
3209:
3202:
3194:
3190:
3185:
3180:
3176:
3172:
3168:
3164:
3160:
3153:
3145:
3141:
3137:
3133:
3130:(9): 521–30.
3129:
3125:
3121:
3114:
3106:
3102:
3097:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3056:
3048:
3041:
3033:
3029:
3024:
3019:
3015:
3011:
3007:
3003:
2999:
2992:
2986:
2980:
2974:
2968:
2962:
2956:
2954:
2947:
2941:
2939:
2922:
2918:
2912:
2910:
2908:
2901:
2897:
2894:
2888:
2880:
2876:
2872:
2868:
2864:
2863:10044/1/34173
2860:
2856:
2852:
2848:
2844:
2840:
2836:
2829:
2821:
2813:
2809:
2804:
2799:
2795:
2791:
2788:(3): 767–79.
2787:
2783:
2779:
2772:
2764:
2760:
2756:
2752:
2748:
2744:
2741:(4): 205–14.
2740:
2736:
2729:
2721:
2717:
2712:
2707:
2704:(2): 303–14.
2703:
2699:
2695:
2688:
2680:
2676:
2671:
2666:
2662:
2658:
2654:
2647:
2639:
2635:
2630:
2625:
2621:
2617:
2613:
2609:
2605:
2598:
2590:
2586:
2582:
2578:
2573:
2568:
2564:
2560:
2556:
2549:
2541:
2537:
2532:
2527:
2522:
2517:
2513:
2509:
2505:
2498:
2490:
2486:
2481:
2476:
2472:
2468:
2464:
2460:
2456:
2449:
2441:
2437:
2432:
2427:
2423:
2419:
2415:
2411:
2407:
2400:
2392:
2388:
2384:
2380:
2375:
2370:
2366:
2362:
2358:
2351:
2343:
2339:
2335:
2331:
2327:
2323:
2315:
2307:
2303:
2298:
2293:
2290:(6): 389–99.
2289:
2285:
2281:
2274:
2266:
2262:
2257:
2252:
2247:
2242:
2238:
2234:
2230:
2223:
2215:
2211:
2207:
2203:
2199:
2195:
2191:
2187:
2183:
2176:
2168:
2164:
2159:
2154:
2150:
2146:
2143:(1): 113–24.
2142:
2138:
2134:
2127:
2119:
2115:
2110:
2105:
2100:
2095:
2091:
2087:
2083:
2076:
2068:
2064:
2060:
2056:
2051:
2046:
2043:(5): 915–27.
2042:
2038:
2034:
2027:
2019:
2015:
2010:
2005:
2001:
1997:
1994:(9): 4881–5.
1993:
1989:
1985:
1978:
1970:
1966:
1961:
1956:
1952:
1948:
1944:
1940:
1936:
1929:
1921:
1917:
1912:
1907:
1903:
1899:
1895:
1891:
1887:
1880:
1872:
1868:
1863:
1858:
1854:
1850:
1847:(4): 369–77.
1846:
1842:
1838:
1831:
1829:
1827:
1825:
1823:
1821:
1812:
1808:
1803:
1798:
1793:
1788:
1784:
1780:
1776:
1772:
1768:
1761:
1746:
1740:
1735:
1734:
1725:
1717:
1713:
1708:
1703:
1699:
1695:
1691:
1687:
1683:
1676:
1668:
1664:
1660:
1656:
1649:
1641:
1637:
1632:
1627:
1622:
1617:
1613:
1609:
1605:
1598:
1596:
1587:
1583:
1578:
1573:
1569:
1565:
1561:
1557:
1553:
1546:
1538:
1534:
1529:
1524:
1519:
1514:
1511:(2): 93–105.
1510:
1506:
1502:
1495:
1487:
1483:
1478:
1473:
1468:
1463:
1459:
1455:
1451:
1447:
1443:
1436:
1428:
1424:
1419:
1414:
1410:
1406:
1402:
1395:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1352:
1344:
1340:
1336:
1332:
1328:
1324:
1317:
1309:
1305:
1301:
1295:
1286:
1278:
1274:
1269:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1236:
1229:
1221:
1217:
1212:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1179:
1171:
1163:
1159:
1154:
1149:
1144:
1139:
1135:
1131:
1127:
1120:
1105:
1101:
1095:
1079:
1075:
1073:
1065:
1057:
1053:
1048:
1043:
1039:
1035:
1031:
1024:
1022:
1015:
1011:
1005:
1003:
994:
990:
986:
982:
978:
974:
971:(6157): 415.
970:
966:
959:
957:
955:
953:
944:
938:
931:
930:
922:
914:
910:
906:
902:
897:
892:
888:
884:
880:
876:
872:
865:
863:
861:
856:
848:
844:
840:
838:
834:
830:
827:
823:
816:Drug research
813:
809:
806:
803:
801:
797:
791:
784:
779:
774:
772:
768:
762:
759:
755:
752:Two types of
749:
739:
737:
731:
728:
724:
720:
719:
718:Aedes aegypti
714:
705:
701:
693:
691:
687:
685:
681:
677:
672:
663:
661:
657:
651:
641:
639:
635:
628:
624:
612:
608:
604:
601:
598:
595:
592:
588:
585:
584:Dengue virus'
582:
581:
575:
573:
572:South America
569:
565:
560:
556:
552:
546:
532:
529:
525:
521:
518:
514:
513:
512:
503:
494:
485:
476:
474:
469:
464:
459:prM/M protein
456:
454:
449:
445:
441:
427:
422:
413:
411:
407:
403:
399:
396:E) and seven
395:
391:
387:
383:
379:
375:
365:
362:
357:
354:
350:
346:
342:
339:and nonhuman
338:
337:
332:
328:
324:
320:
316:
308:
304:
295:
293:
288:
286:
285:viral species
282:
278:
270:
266:
262:
252:
249:
245:
243:
242:
237:
236:
231:
227:
222:
218:
217:
212:
211:
206:
203:
199:
195:
191:
187:
186:
176:
175:
170:
167:
166:
163:
162:
158:
155:
154:
151:
150:
146:
143:
142:
139:
138:
134:
131:
130:
127:
126:
122:
119:
118:
115:
114:
110:
107:
106:
103:
102:
101:Orthornavirae
98:
95:
94:
91:
90:
86:
83:
80:
79:
76:
73:
70:
69:
64:
59:
55:
51:
48:
44:
41:
36:
32:
27:
24:
20:
5769:Dengue fever
5764:Flaviviruses
5668:Dengue virus
5638:Dengue virus
5637:
5594:
5585:Mokola virus
5562:
5524:
5496:Retroviridae
5494:
5482:
5472:
5420:
5388:
5341:
5282:
5255:
5245:
5178:Bunyavirales
5176:
5093:Arenaviridae
5091:
5041:
4993:Bunyavirales
4991:
4946:
4926:
4912:Langat virus
4846:Flaviviridae
4844:
4835:Bhanja virus
4792:Bunyavirales
4790:
4755:
4655:
4627:Yellow fever
4619:
4615:Dengue fever
4535:Flaviviridae
4533:
4478:Tahyna virus
4443:Bwamba Fever
4420:Bunyavirales
4418:
4333:
4309:
4289:
4282:
4262:Dengue virus
4260:
4259:
4258:profile for
4255:
4226:
4222:
4212:
4203:
4199:
4189:
4154:
4150:
4140:
4105:
4101:
4091:
4048:
4044:
4034:
4001:10072/347872
3981:
3977:
3967:
3955:
3946:
3937:
3903:(9): e2261.
3900:
3896:
3886:
3866:
3855:
3836:
3822:
3810:. Retrieved
3805:
3796:
3784:. Retrieved
3779:
3775:
3763:
3751:. Retrieved
3722:. Retrieved
3671:
3667:
3657:
3620:
3616:
3562:
3558:
3548:
3513:
3509:
3499:
3464:
3460:
3450:
3413:
3409:
3399:
3372:
3368:
3358:
3323:
3319:
3309:
3264:
3260:
3250:
3215:
3211:
3201:
3166:
3162:
3152:
3127:
3123:
3113:
3070:
3066:
3055:
3046:
3040:
3008:(1): 83–92.
3005:
3001:
2991:
2979:
2967:
2925:. Retrieved
2920:
2887:
2838:
2834:
2820:
2785:
2781:
2771:
2738:
2734:
2728:
2701:
2697:
2687:
2660:
2656:
2646:
2611:
2607:
2597:
2565:(3): 312–7.
2562:
2558:
2548:
2511:
2507:
2497:
2462:
2458:
2448:
2413:
2409:
2399:
2364:
2360:
2350:
2325:
2321:
2314:
2287:
2283:
2273:
2236:
2232:
2222:
2192:(1): 84–97.
2189:
2185:
2175:
2140:
2136:
2126:
2089:
2085:
2075:
2040:
2036:
2026:
1991:
1987:
1977:
1945:(7): 823–9.
1942:
1938:
1928:
1896:(7): 723–8.
1893:
1890:EMBO Reports
1889:
1879:
1844:
1840:
1774:
1770:
1760:
1750:22 September
1748:. Retrieved
1732:
1724:
1689:
1685:
1675:
1658:
1654:
1648:
1611:
1607:
1559:
1555:
1545:
1508:
1504:
1494:
1449:
1445:
1435:
1411:(2): 134–9.
1408:
1404:
1394:
1361:
1357:
1351:
1329:(1): 19–28.
1326:
1322:
1316:
1308:the original
1303:
1294:
1285:
1245:(1): 67–70.
1242:
1238:
1228:
1185:
1181:
1170:
1133:
1130:PLOS Biology
1129:
1119:
1108:. Retrieved
1103:
1094:
1082:. Retrieved
1078:ScienceDaily
1077:
1072:Dengue virus
1071:
1064:
1037:
1033:
1010:Dengue virus
1009:
968:
964:
928:
926:WHO (2009).
921:
878:
874:
845:
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837:hepatitis C
833:Balapiravir
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277:World War I
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