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Type 2 diabetes

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901: 1953: 511: 57: 1726: 1579:, improves a person's life expectancy. Decreasing the systolic blood pressure to less than 140 mmHg is associated with a lower risk of death and better outcomes. Intensive blood pressure management (less than 130/80 mmHg) as opposed to standard blood pressure management (less than 140-160 mmHg systolic to 85–100 mmHg diastolic) results in a slight decrease in stroke risk but no effect on overall risk of death. 483:. As of 2015, there were approximately 392 million people diagnosed with the disease compared to around 30 million in 1985. Typically, it begins in middle or older age, although rates of type 2 diabetes are increasing in young people. Type 2 diabetes is associated with a ten-year-shorter life expectancy. Diabetes was one of the first diseases ever described, dating back to an Egyptian manuscript from 1456:
reduce the risk of diabetes by about 28%. Evidence for the benefit of dietary changes alone, however, is limited, with some evidence for a diet high in green leafy vegetables and some for limiting the intake of sugary drinks. There is an association between higher intake of sugar-sweetened fruit juice and diabetes, but no evidence of an association with 100% fruit juice. A 2019 review found evidence of benefit from
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and life expectancy. Hypoglycemia is associated with adverse outcomes in older people with type 2 diabetes. Despite guidelines recommending that intensive blood sugar control be based on balancing immediate harms with long-term benefits, many people – for example people with a life expectancy of
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Onset of type 2 diabetes can be delayed or prevented through proper nutrition and regular exercise. Intensive lifestyle measures may reduce the risk by over half. The benefit of exercise occurs regardless of the person's initial weight or subsequent weight loss. High levels of physical activity
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Rates of diabetes in 1985 were estimated at 30 million, increasing to 135 million in 1995 and 217 million in 2005. This increase is believed to be primarily due to the global population aging, a decrease in exercise, and increasing rates of obesity. Traditionally considered a disease
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Many international guidelines recommend blood pressure treatment targets that are lower than 140/90 mmHg for people with diabetes. However, there is only limited evidence regarding what the lower targets should be. A 2016 systematic review found potential harm to treating to targets lower than
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may either be added to oral medication or used alone. Most people do not initially need insulin. When it is used, a long-acting formulation is typically added at night, with oral medications being continued. Doses are then increased to effect (blood sugar levels being well controlled). When nightly
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release. However, in the setting of insulin resistance, the liver inappropriately releases glucose into the blood. The proportion of insulin resistance versus beta cell dysfunction differs among individuals, with some having primarily insulin resistance and only a minor defect in insulin secretion
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to promote weight loss is generally recommended. Around 80 percent of obese people with type 2 diabetes achieve complete remission with no need for medication if they sustain a weight loss of at least 15 kilograms (33 lb), but most patients are not able to achieve or sustain significant
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threshold of ≥ 48 mmol/mol (≥ 6.5 DCCT %) should be used to diagnose diabetes. This recommendation was adopted by the American Diabetes Association in 2010. Positive tests should be repeated unless the person presents with typical symptoms and blood sugar >11.1 mmol/L
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in the normal range. Self-monitoring of blood glucose for people with newly diagnosed type 2 diabetes may be used in combination with education, although the benefit of self-monitoring in those not using multi-dose insulin is questionable. In those who do not want to measure blood levels,
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intervention, appeared to delay or reduce the risk of developing type 2 diabetes. This same review found moderate-quality evidence that when compared to intensive diet and exercise, Metformin did not reduce risk of developing type 2 diabetes, as well as very low-quality evidence that
8529:"Aspirin for primary prevention of cardiovascular events in people with diabetes: a position statement of the American Diabetes Association, a scientific statement of the American Heart Association, and an expert consensus document of the American College of Cardiology Foundation" 2108:
In 2020, Diabetes Severity Score (DISSCO) was developed which is a tool that might better than HbA1c identify if a person's condition is declining. It uses a computer algorithm to analyse data from anonymised electronic patient records and produces a score based on 34 indicators.
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has the advantages that fasting is not required and results are more stable but has the disadvantage that the test is more costly than measurement of blood glucose. It is estimated that 20% of people with diabetes in the United States do not realize that they have the disease.
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rates. The five countries with the greatest number of people with diabetes as of 2000 are India having 31.7 million, China 20.8 million, the United States 17.7 million, Indonesia 8.4 million, and Japan 6.8 million. It is recognized as a global
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is an effective measure to treat diabetes. Many are able to maintain normal blood sugar levels with little or no medication following surgery and long-term mortality is decreased. There however is some short-term mortality risk of less than 1% from the surgery. The
1899:(acetylsalicylic acid) to prevent cardiovascular disease in diabetes is controversial. Aspirin is recommended in people with previous cardiovascular disease, however routine use of aspirin has not been found to improve outcomes in uncomplicated diabetes. Aspirin as 1696:
Culturally appropriate education may help people with type 2 diabetes control their blood sugar levels for up to 24 months. There is not enough evidence to determine if lifestyle interventions affect mortality in those who already have type 2 diabetes.
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combining metformin with intensive diet and exercise does not appear to have any effect on risk of developing type 2 diabetes when compared to intensive diet and exercise alone. This systematic review only found one suitable trial comparing metformin with
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are at particularly high risk of developing type 2 diabetes. Type 2 diabetes in normal weight individuals represents 60 to 80 percent of all cases in some Asian countries. The mechanism causing diabetes in non-obese individuals is poorly understood.
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A proper diet and regular exercise are foundations of diabetic care, with one review indicating that a greater amount of exercise improved outcomes. Regular exercise may improve blood sugar control, decrease body fat content, and decrease blood lipid levels.
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The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors. While some of these factors are under personal control, such as diet and obesity, other factors are not, such as increasing age, female sex, and genetics.
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Type 2 diabetes is typically a chronic disease associated with a ten-year-shorter life expectancy. This is partly due to a number of complications with which it is associated, including: two to four times the risk of cardiovascular disease, including
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Mannucci E, Giaccari A, Gallo M, Bonifazi A, Belén ÁD, Masini ML, et al. (February 2022). "Self-management in patients with type 2 diabetes: Group-based versus individual education. A systematic review with meta-analysis of randomized trails".
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may have greater risk than benefit, but could be considered in people aged 50 to 70 with another significant cardiovascular risk factor and low risk of bleeding after information about possible risks and benefits as part of shared-decision making.
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descent the recommendation to start prevention starts at the BMI of 27,5. A study based on a large sample of people in England suggest even lower BMIs for certain ethnic groups for the start of prevention, for example 24 in South Asian and 21 in
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Cobelli C, Toffolo GM, Dalla Man C, Campioni M, Denti P, Caumo A, et al. (July 2007). "Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests".
7912:"Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis" 980:
The causes of the aging-related insulin resistance seen in obesity and in type 2 diabetes are uncertain. Effects of intracellular lipid metabolism and ATP production in liver and muscle cells may contribute to insulin resistance.
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Hyberbolic relationship between insulin sensitivity and beta cell function showing dynamical compensation in "healthy" insulin resistance (transition from A to B) and the evolution of type 2 diabetes mellitus (transition from A to C).
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Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, et al. (June 2016). "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis".
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Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018 Oct;67(10):1923-1931. doi: 10.2337/db18-0537. PMID 30237160; PMCID:
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in preventing cardiovascular disease. Although a 2016 review found similar effects of ACEIs and ARBs on major cardiovascular and renal outcomes. There is no evidence that combining ACEIs and ARBs provides additional benefits.
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is generally recommended as a first line treatment as there is some evidence that it decreases mortality; however, this conclusion is questioned. Metformin should not be used in those with severe kidney or liver problems. The
5784:"Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013" 8323:"Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis" 8011:
Chen X, Yang L, Zhai SD (December 2012). "Risk of cardiovascular disease and all-cause mortality among diabetic patients prescribed rosiglitazone or pioglitazone: a meta-analysis of retrospective cohort studies".
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has also been linked to type 2 diabetes. Laboratory studies have linked short-term sleep deprivations to changes in glucose metabolism, nervous system activity, or hormonal factors that may lead to diabetes.
9478: 9463: 1541:. The same review found that there was no conclusive evidence that voglibose compared to diet and exercise or placebo reduced incidence of diabetes mellitus type 2, or any of the other measured outcomes. 3736:
Abdullah A, Peeters A, de Courten M, Stoelwinder J (September 2010). "The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies".
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with people who have type 2 diabetes helps them to reduce their blood sugar levels. It is a way of helping people understand their own health condition and involving them actively in its management.
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that is a new onset of high blood sugars associated with pregnancy. Type 1 and type 2 diabetes can typically be distinguished based on the presenting circumstances. If the diagnosis is in doubt
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140 mmHg, and a subsequent review in 2019 found no evidence of additional benefit from blood pressure lowering to between 130–140 mmHg, although there was an increased risk of adverse events.
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integrate beta cell function and insulin sensitivity in a way so that the results remain constant across dynamical compensation. Changed from Cobelli et al. 2007, Hannon et al. 2018 and Dietrich et al.
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mentioning "too great emptying of the urine." The first described cases are believed to be of type 1 diabetes. Indian physicians around the same time identified the disease and classified it as
8364:"Effects of aliskiren on mortality, cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review and meta-analysis of 13,395 patients" 1594:
of 7 to 8% or a fasting glucose of less than 7.2 mmol/L (130 mg/dL); however these goals may be changed after professional clinical consultation, taking into account particular risks of
785:, for example, increases the risk of developing diabetes by 1.5 times and is the greatest risk of the common genetic variants. Most of the genes linked to diabetes are involved in pancreatic 589:. In the developed world, and increasingly elsewhere, type 2 diabetes is the largest cause of nontraumatic blindness and kidney failure. It has also been associated with an increased risk of 9593: 2572:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015" 1808:, a thiazolidinedione, has not been found to improve long-term outcomes even though it improves blood sugar levels. Additionally it is associated with increased rates of heart disease and death. 6586:"Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians" 2203: 1685:) reduced fasting blood glucose in diabetic people. As of 2015, there is insufficient data to recommend nonnutritive sweeteners, which may help reduce caloric intake. An elevated intake of 7368:"Higher intake of microbiota-accessible carbohydrates and improved cardiometabolic risk factors: a meta-analysis and umbrella review of dietary management in patients with type 2 diabetes" 1938:
cutoffs for when surgery is appropriate are not yet clear. It is recommended that this option be considered in those who are unable to get both their weight and blood sugar under control.
6441:"Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials" 5656:"Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus" 778:(SNPs) had been found that contribute to the risk of type 2 diabetes. All of these genes together still only account for 10% of the total heritable component of the disease. The 6150:"Alpha-glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus" 6981: 3593:"Differences by sex in the prevalence of diabetes mellitus, impaired fasting glycaemia and impaired glucose tolerance in sub-Saharan Africa: a systematic review and meta-analysis" 9388: 4635:
Nieto-Martínez R, González-Rivas JP, Medina-Inojosa JR, Florez H (November 2017). "Are Eating Disorders Risk Factors for Type 2 Diabetes? A Systematic Review and Meta-analysis".
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A weight loss of ~15 kg, achieved by calorie restriction as part of an intensive management programme, can lead to remission of T2DM in ~80% of patients with obesity and T2DM.
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appeared to reduce incidence of diabetes mellitus type 2 when compared to placebo, however there was no conclusive evidence that acarbose compare to diet and exercise,
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Muley A, Fernandez R, Ellwood L, Muley P, Shah M (May 2021). "Effect of tree nuts on glycemic outcomes in adults with type 2 diabetes mellitus: a systematic review".
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definition of diabetes (both type 1 and type 2) is for a single raised glucose reading with symptoms, otherwise raised values on two occasions, of either:
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In the early stages of insulin resistance, the mass of beta cells expands, increasing the output of insulin to compensate for the insulin insensitivity, so that the
4071:"Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis" 1366:(ADA) recommended in 2024 screening in all adults from the age of 35 years. ADA also recommends screening in adults of all ages with a BMI over 25 (or over 23 in 9579: 8420:"Cardiovascular and Renal Outcomes of Renin-Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: A Systematic Review with Network Meta-Analyses" 3435:
Akinpelu OV, Mujica-Mota M, Daniel SJ (March 2014). "Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta-analysis".
7319:"Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association" 3414: 5833:
Nield L, Summerbell CD, Hooper L, Whittaker V, Moore H (July 2008). Nield L (ed.). "Dietary advice for the prevention of type 2 diabetes mellitus in adults".
1804:. A 2018 review found that SGLT2 inhibitors and GLP-1 agonists, but not DPP-4 inhibitors, were associated with lower mortality than placebo or no treatment. 8666: 7744: 7091: 2868:
Moscou S (2013). "Getting the word out: advocacy, social marketing, and policy development and enforcement". In Truglio-Londrigan M, Lewenson SB (eds.).
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Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. (GBD 2015 Disease and Injury Incidence and Prevalence Collaborators) (October 2016).
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Type 2 diabetes is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. This is in contrast to
7409:"Should Viscous Fiber Supplements Be Considered in Diabetes Control? Results From a Systematic Review and Meta-analysis of Randomized Controlled Trials" 4183:"The Concordance and Heritability of Type 2 Diabetes in 34,166 Twin Pairs From International Twin Registers: The Discordant Twin (DISCOTWIN) Consortium" 6532: 6248:"Clinical review: Effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis" 970:. However, not all people with insulin resistance develop diabetes since an impairment of insulin secretion by pancreatic beta cells is also required. 8475: 8269: 5611:
Raina Elley C, Kenealy T (December 2008). "Lifestyle interventions reduced the long-term risk of diabetes in adults with impaired glucose tolerance".
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Saenz A, Fernandez-Esteban I, Mataix A, Ausejo M, Roque M, Moher D (July 2005). Saenz A (ed.). "Metformin monotherapy for type 2 diabetes mellitus".
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There is no evidence that screening changes the risk of death and any benefit of screening on adverse effects, incidence of type 2 diabetes, HbA
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levels may be useful to confirm type 2 diabetes, with C-peptide levels normal or high in type 2 diabetes, but low in type 1 diabetes.
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estimates nearly 537 million people lived with diabetes worldwide in 2021, 90–95% of whom have type 2 diabetes. Diabetes is common both in the
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A 2017 review found that, long term, lifestyle changes decreased the risk by 28%, while medication does not reduce risk after withdrawal. While low
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American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, et al. (2024-01-01).
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American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, et al. (2024-01-01).
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American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, et al. (2024-01-01).
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American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, et al. (2024-01-01).
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American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, et al. (2024-01-01).
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American Diabetes Association Professional Practice Committee, ElSayed NA, Aleppo G, Bannuru RR, Bruemmer D, Collins BS, et al. (2024-01-01).
5148: 8172:"Effect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses" 7010: 10365: 8702:"The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation" 1758: 1200: 9333:"Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study" 10129: 7603:"Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes: A Meta-analysis" 5528: 6784:"Physical activity and incident type 2 diabetes mellitus: a systematic review and dose-response meta-analysis of prospective cohort studies" 4769:"A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" 8221:"Benefits and harms of lower blood pressure treatment targets: systematic review and meta-analysis of randomised placebo-controlled trials" 1328: 6148:
Moelands SV, Lucassen PL, Akkermans RP, De Grauw WJ, Van de Laar FA (2018-12-28). Cochrane Metabolic and Endocrine Disorders Group (ed.).
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Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B, et al. (Cochrane Metabolic and Endocrine Disorders Group) (December 2019).
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Zaccardi F, Webb DR, Yates T, Davies MJ (February 2016). "Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective".
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In 1916, Elliot Joslin proposed that in people with diabetes, periods of fasting are helpful. Subsequent research has supported this, and
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levels are associated with an increased risk of diabetes, correcting the levels by supplementing vitamin D3 does not improve that risk.
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Schulman AP, del Genio F, Sinha N, Rubino F (September–October 2009). ""Metabolic" surgery for treatment of type 2 diabetes mellitus".
8619:"Impact of providing patients access to electronic health records on quality and safety of care: a systematic review and meta-analysis" 4845: 9304: 3277: 2328: 3382: 429:
Type 2 diabetes is largely preventable by staying at a normal weight, exercising regularly, and eating a healthy diet (high in
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Management of type 2 diabetes focuses on lifestyle interventions, lowering other cardiovascular risk factors, and maintaining
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Threshold for diagnosis of diabetes is based on the relationship between results of glucose tolerance tests, fasting glucose or HbA
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Other potentially important mechanisms associated with type 2 diabetes and insulin resistance include: increased breakdown of
17: 4022:"Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy" 1650:
weight loss. Even modest weight loss can produce significant improvements in glycemic control and reduce the need for medication.
1191: %) is another method of diagnosing diabetes. In 2009 an International Expert Committee that included representatives of the 7560:
Ee CC, Armour M, Piya MK, McMorrow R, Al-Kanini I, Sabag A (2021-12-23). Cochrane Metabolic and Endocrine Disorders Group (ed.).
6199:"Long-term Sustainability of Diabetes Prevention Approaches: A Systematic Review and Meta-analysis of Randomized Clinical Trials" 2147: 4939: 4720:"Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium" 4118: 2046:
noting that the urine would attract ants. The term "diabetes" or "to pass through" was first used in 230 BCE by the Greek
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remains constant. But when type 2 diabetes has become manifest, the person will have lost about half of their beta cells.
6400:"Intensive and Standard Blood Pressure Targets in Patients With Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis" 826:
There are a number of medications and other health problems that can predispose to diabetes. Some of the medications include:
8979: 8926:"Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations" 5319: 5290: 5258: 4956: 4824: 4386: 3121: 3067: 2881: 2690: 2628: 2551: 9893: 9838: 9641: 5494: 4890:"A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives" 4843:
Sun T, Han X (2019). "Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes".
1283:. A fasting or random blood sugar is preferred over the glucose tolerance test, as they are more convenient for people. HbA 801: 8966: 5008: 1420:
guidelines suggest taking action to prevent diabetes for people with a body mass index (BMI) of 30 or more. For people of
10334: 9497: 7092:"5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes—2024" 4339: 2047: 667: 7644:"Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials" 3774:"Relation of active, passive, and quitting smoking with incident type 2 diabetes: a systematic review and meta-analysis" 2061:
Type 1 and type 2 diabetes were identified as separate conditions for the first time by the Indian physicians
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or severe obesity. ADA recommends repeat screening every 3 years at minimum. ADA recommends yearly tests in people with
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US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, et al. (2021-08-24).
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Izzedine H, Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G (November 2005). "Drug-induced diabetes mellitus".
1992: 1429: 5564:"Ethnicity-specific BMI cutoffs for obesity based on type 2 diabetes risk in England: a population-based cohort study" 1863:) to reduce the risks of progression of kidney disease and present cardiovascular events. There is some evidence that 1347:, screening is recommended if they have a BMI over 23. Screening at an earlier age may be considered in people with a 10288: 9938: 3406: 1965: 1196: 757: 9019:"The Pathophysiology of Type 2 Diabetes Mellitus in Non-obese Individuals: An Overview of the Current Understanding" 10164: 8578:"The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis" 6627:"Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society" 2082: 1952: 1793: 1425: 559: 555: 361: 158: 7194:"Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base" 5708:"Lifestyle interventions for patients with and at risk for type 2 diabetes: a systematic review and meta-analysis" 8473: 8267: 7742: 7642:
Boussageon R, Supper I, Bejan-Angoulvant T, Kellou N, Cucherat M, Boissel JP, et al. (2012). Groop L (ed.).
7089: 6676:"An Evidence-Based Medicine Approach to Antihyperglycemic Therapy in Diabetes Mellitus to Overcome Overtreatment" 6530: 6439:
Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassaï B, et al. (July 2011).
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A random blood sugar of greater than 11.1 mmol/L (200 mg/dL) in association with typical symptoms or a
336:(wounds) that do not heal. Often, symptoms develop slowly. Long-term complications from high blood sugar include 5934:"Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies" 2176: 9749: 812:, among others. Maturity onset diabetes of the young constitute 1–5% of all cases of diabetes in young people. 809: 775: 761: 9389:"New tool for assessing the severity of type 2 diabetes could help personalise treatment and improve outcomes" 5529:"Are you at risk of diabetes? Research finds prevention should start at a different BMI for each ethnic group" 4941:
Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: Report of a WHO/IDF consultation
2765: 10054: 9765: 4715: 1868: 1754: 1450: 1363: 1192: 7458:"Culturally appropriate health education for people in ethnic minority groups with type 2 diabetes mellitus" 6723:
Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, et al. (April 14, 2022).
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Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus".
2238:"Hyperosmolar hyperglycemic state: a historic review of the clinical presentation, diagnosis, and treatment" 1351:
of diabetes; some ethnic groups, including Hispanics, African Americans, and Native Americans; a history of
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are at a higher risk of developing type 2 diabetes. Other health problems that are associated include:
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status of a mother during fetal development may also play a role, with one proposed mechanism being that of
10094: 10021: 9236: 5885:"Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis" 5354:"Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement" 1860: 745: 9076:
Salvatore T, Galiero R, Caturano A, Rinaldi L, Criscuolo L, Di Martino A, et al. (30 December 2022).
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Hemmingsen B, Gimenez-Perez G, Mauricio D, Roqué I, Figuls M, Metzendorf MI, et al. (December 2017).
1529:, reduced or increased risk of cardiovascular mortality, serious or non-serious adverse events, non-fatal 1331:(USPSTF) recommended in 2021 screening for type 2 diabetes in adults aged 35 to 70 years old who are 10006: 9931: 9926: 9607: 5403:"Screening for type 2 diabetes mellitus: a systematic review for the U.S. Preventive Services Task Force" 3681:
Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, et al. (July 2016).
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supplementation to people with type 2 diabetes may improve markers of insulin resistance and HbA1c.
1827:, but as they are significantly more expensive, they are not cost effective as of 2010. In those who are 1498: 792:
There are a number of rare cases of diabetes that arise due to an abnormality in a single gene (known as
419: 7040:"8. Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes—2021" 672:
Lifestyle factors are important to the development of type 2 diabetes, including obesity and being
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Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, et al. (August 2016).
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Pasquier F (October 2010). "Diabetes and cognitive impairment: how to evaluate the cognitive status?".
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Ripsin CM, Kang H, Urban RJ (January 2009). "Management of blood glucose in type 2 diabetes mellitus".
1464: 1102: 1077: 713: 465: 8090:"Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation" 2766:"Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin" 10141: 10089: 9986: 9331:
Zghebi SS, Mamas MA, Ashcroft DM, Salisbury C, Mallen CD, Chew-Graham CA, et al. (May 5, 2020).
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Picot J, Jones J, Colquitt JL, Gospodarevskaya E, Loveman E, Baxter L, et al. (September 2009).
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Davis N, Forbes B, Wylie-Rosett J (June 2009). "Nutritional strategies in type 2 diabetes mellitus".
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Although psychological stress is recognized as a risk factor for type 2 diabetes, the effect of
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insulin is insufficient, twice daily insulin may achieve better control. The long acting insulins
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with type 1 associated with youth and type 2 with being overweight. The importance of
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of adults, type 2 diabetes is increasingly diagnosed in children in parallel with rising
1487:
in reducing risk of type 2 diabetes but it did not report any patient-relevant outcomes.
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5994: 4287: 3694: 1811: 1438: 1421: 1399: 1352: 1321: 1300: 874:. Individuals with cancer may be at a higher risk of mortality if they also have diabetes. 847: 712:
Dietary factors also influence the risk of developing type 2 diabetes. Consumption of
685: 654: 606: 461: 395: 345: 174: 9440: 1892:
should be considered after evaluating the person's total risk for cardiovascular disease.
8: 10329: 10314: 10243: 10228: 10223: 10206: 10191: 10176: 10119: 10114: 10079: 10046: 9976: 9559: 9482: 8131:"A Roadmap on the Prevention of Cardiovascular Disease Among People Living With Diabetes" 6042:"Carbohydrate quality and human health: a series of systematic reviews and meta-analyses" 3973:"White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review" 2022: 1739: 1646: 1590:
of 7–7.9%) does not appear to change mortality. The goal of treatment is typically an HbA
1563: 1557: 1510: 1387: 1180: 741: 737: 729: 725: 701: 681: 617:, and frequent infections. There is also an association between type 2 diabetes and mild 423: 376: 333: 9430: 7853:
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measuring urine levels may be done. Managing other cardiovascular risk factors, such as
926:
to respond adequately to normal levels of insulin, occurs primarily within the muscles,
10293: 9881: 9732: 9711: 9603: 9491: 9487: 9404: 9365: 9332: 9281: 9256: 9171: 9136: 9112: 9077: 9053: 9018: 8906: 8863: 8782: 8682: 8667:"Sharing electronic records with patients led to improved control of type two diabetes" 8643: 8618: 8553: 8528: 8446: 8419: 8388: 8363: 8245: 8220: 8196: 8171: 8065: 8040: 8039:
Swinnen SG, Simon AC, Holleman F, Hoekstra JB, Devries JH (July 2011). Simon AC (ed.).
7988: 7936: 7911: 7887: 7854: 7745:"9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes—2024" 7722: 7670: 7643: 7586: 7561: 7542: 7438: 7343: 7318: 7299: 7169: 7144: 7069: 6960: 6870: 6857: 6832: 6808: 6783: 6759: 6724: 6700: 6675: 6651: 6626: 6513: 6465: 6440: 6321: 6272: 6247: 6223: 6198: 6174: 6149: 6120: 6095: 6071: 6017: 5982: 5958: 5933: 5909: 5884: 5862: 5810: 5783: 5680: 5655: 5636: 5588: 5563: 5544: 5510: 5468: 5443: 5226: 5201: 5113: 5088: 5064: 5039: 4916: 4889: 4870: 4744: 4719: 4660: 4576: 4528: 4503: 4479: 4454: 4435: 4308: 4275: 4256: 4163: 4095: 4070: 4046: 4021: 3997: 3972: 3948: 3923: 3899: 3874: 3855: 3798: 3773: 3718: 3642:"Maternal micronutrient deficiency, fetal development, and the risk of chronic disease" 3617: 3592: 3568: 3535: 3511: 3486: 3460: 3232: 3170: 3028: 3003: 2979: 2954: 2935: 2845: 2820: 2801: 2596: 2571: 2489: 2438: 2411: 2389: 2262: 2237: 2155: 1900: 1658: 992: 919: 631: 610: 468:) is advised; however, this may not be needed in those who are not on insulin therapy. 301: 129: 9395:(Plain English summary). National Institute for Health and Care Research. 2020-08-07. 8894: 7960: 7710: 7695:"Guideline recommendations and the positioning of newer drugs in type 2 diabetes care" 6691: 6058: 6041: 5579: 5535:(Plain English summary). National Institute for Health and Care Research. 2022-03-10. 5351: 4037: 3890: 3789: 3360: 2587: 10099: 10036: 9966: 9921: 9794: 9672: 9615: 9519: 9408: 9370: 9352: 9286: 9217: 9196:"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030" 9176: 9158: 9117: 9099: 9058: 9040: 8975: 8947: 8898: 8867: 8855: 8820: 8774: 8733: 8728: 8686: 8648: 8599: 8558: 8509: 8497: 8451: 8413: 8393: 8344: 8303: 8291: 8250: 8201: 8152: 8111: 8070: 8021: 7993: 7941: 7892: 7874: 7835: 7817: 7778: 7766: 7726: 7714: 7675: 7624: 7534: 7526: 7487: 7430: 7389: 7348: 7303: 7291: 7256: 7215: 7174: 7125: 7113: 7073: 7061: 6964: 6952: 6944: 6905: 6862: 6813: 6764: 6705: 6656: 6607: 6566: 6554: 6505: 6470: 6421: 6380: 6325: 6313: 6277: 6228: 6179: 6125: 6063: 6022: 5963: 5914: 5854: 5815: 5764: 5729: 5685: 5628: 5593: 5548: 5514: 5473: 5424: 5383: 5375: 5325: 5315: 5286: 5254: 5231: 5182: 5170: 5118: 5069: 4989: 4952: 4921: 4874: 4862: 4820: 4790: 4749: 4696: 4652: 4617: 4568: 4533: 4484: 4427: 4392: 4382: 4338:. National Institute of Diabetes and Digestive and Kidney Diseases, NIH. March 2007. 4313: 4248: 4243: 4226: 4204: 4155: 4150: 4133: 4100: 4051: 4002: 3953: 3904: 3847: 3803: 3754: 3710: 3663: 3622: 3573: 3555: 3516: 3452: 3364: 3329: 3259: 3236: 3224: 3162: 3158: 3127: 3117: 3073: 3063: 3033: 2984: 2927: 2887: 2877: 2850: 2805: 2793: 2746: 2727: 2696: 2686: 2634: 2624: 2601: 2547: 2481: 2477: 2443: 2381: 2297: 2267: 2078: 2001: 1984: 1926: 1789: 1706: 1494: 1471: 1296: 1127: 974: 935:
and others with slight insulin resistance and primarily a lack of insulin secretion.
906: 721: 602: 469: 293: 252: 233: 219: 117: 8786: 8476:"10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2024" 8270:"11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2024" 7546: 7442: 6924: 6874: 6517: 6416: 6399: 6214: 6075: 5866: 5640: 4580: 4439: 4260: 4167: 3859: 3464: 3174: 2970: 2493: 2393: 1175:, two hours after the oral dose a plasma glucose ≥ 11.1 mmol/L (200 mg/dL) 10074: 9699: 9396: 9360: 9344: 9276: 9268: 9207: 9166: 9148: 9107: 9089: 9048: 9030: 8937: 8910: 8890: 8847: 8812: 8764: 8723: 8713: 8674: 8638: 8630: 8589: 8548: 8540: 8505: 8487: 8441: 8431: 8383: 8375: 8339: 8334: 8322: 8299: 8281: 8240: 8232: 8191: 8183: 8142: 8101: 8088:
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Rates of type 2 diabetes have increased markedly since 1960 in parallel with
10273: 9943: 9831: 9737: 9626: 9513: 9272: 8769: 8752: 8436: 8147: 8130: 7660: 7456:
Attridge M, Creamer J, Ramsden M, Cannings-John R, Hawthorne K (September 2014).
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Diabetes is one of the first diseases described with an Egyptian manuscript from
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and stroke; a 20-fold increase in lower limb amputations, and increased rates of
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is often present. Smoking appears to increase the risk of type 2 diabetes.
464:. In those on insulin, routinely checking blood sugar levels (such as through a 10233: 10106: 9348: 8415: 6925:"Diet and exercise in the prevention and treatment of type 2 diabetes mellitus" 6584:
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in 1921 and 1922. This was followed by the development of the longer acting
1324:
for diabetes in people without risk factors or symptoms is not recommended.
900: 510: 10255: 9996: 9991: 9706: 9374: 9290: 9221: 9180: 9153: 9121: 9062: 8951: 8902: 8859: 8824: 8778: 8737: 8652: 8603: 8562: 8513: 8455: 8397: 8348: 8307: 8254: 8205: 8156: 8115: 8074: 8025: 7997: 7945: 7927: 7896: 7839: 7782: 7718: 7679: 7628: 7619: 7602: 7538: 7522: 7491: 7434: 7393: 7384: 7367: 7352: 7295: 7260: 7219: 7178: 7129: 7065: 6956: 6909: 6866: 6817: 6768: 6709: 6660: 6611: 6570: 6509: 6474: 6425: 6384: 6317: 6281: 6232: 6183: 6129: 6067: 6026: 5967: 5918: 5858: 5819: 5768: 5733: 5706:
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5689: 5632: 5597: 5477: 5428: 5387: 5235: 5186: 5122: 5073: 4993: 4925: 4866: 4794: 4753: 4700: 4656: 4621: 4572: 4537: 4488: 4431: 4317: 4252: 4208: 4159: 4104: 4055: 4006: 3957: 3908: 3851: 3842: 3825: 3807: 3758: 3714: 3667: 3626: 3577: 3520: 3456: 3368: 3333: 3263: 3228: 3166: 3037: 2988: 2931: 2854: 2797: 2750: 2731: 2605: 2485: 2447: 2385: 2301: 2271: 2051: 1844: 1785: 1662: 1595: 1568: 1506: 1484: 1403: 1379: 835: 771: 693: 689: 56: 9435: 8594: 8577: 7562:"Mindfulness-based interventions for adults with type 2 diabetes mellitus" 3658: 3641: 3608: 1725: 1618:
results in an improvement in blood sugar levels for people with diabetes.
10298: 10026: 9864: 9543: 9137:"Maternal low protein diet and fetal programming of lean type 2 diabetes" 9094: 7145:"Low glycaemic index, or low glycaemic load, diets for diabetes mellitus" 6263: 5624: 4906: 3683:"Human gut microbes impact host serum metabolome and insulin sensitivity" 2097: 2090: 1848: 1824: 1769:
as the first-line treatment in patients who have or are at high risk for
1714: 1611: 1502: 1395: 1280: 871: 563: 321: 142: 9455: 9400: 9035: 8816: 8678: 6533:"6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2024" 5540: 4299: 4199: 4182: 3706: 3680: 3551: 1606:
It is recommended that all people with type 2 diabetes get regular
9958: 9770: 5850: 3448: 2872:(2nd ed.). Burlington, MA: Jones & Bartlett Learning. p.  2074: 2070: 2035: 1332: 1295:
in which there is an absolute insulin deficiency due to destruction of
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Type 2 diabetes is due to insufficient insulin production from
10031: 9817: 8575: 7455: 7015: 6722: 5883:
Carter P, Gray LJ, Troughton J, Khunti K, Davies MJ (August 2010).
5561: 4273: 2062: 2006: 1828: 1823:
are equally safe and effective, and do not appear much better than
1682: 1514: 1305: 951: 947: 943: 831: 594: 535: 519: 456:. If blood sugar levels are not adequately lowered, the medication 449: 411: 387: 380: 313: 212: 138: 9601: 4409: 2713: 2179:. International Diabetes Federation. 17 March 2006. Archived from 2073:
with type 1 associated with youth and type 2 with being
460:
is typically recommended. Many people may eventually also require
9723: 9257:"Strategies of Unloading the Failing Heart from Metabolic Stress" 9255:
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National Institute of Diabetes and Digestive and Kidney Diseases
7191: 6986:
National Institute of Diabetes and Digestive and Kidney Diseases
2333:
National Institute of Diabetes and Digestive and Kidney Diseases
2208:
National Institute of Diabetes and Digestive and Kidney Diseases
9914: 9911: 9908: 9905: 9902: 9899: 9659: 9656: 9653: 9650: 9647: 9644: 9467: 9075: 7852: 7406: 5501:. National Institute for Health and Care Research. 2022-07-26. 5253:(7th ed.). Philadelphia, Pa.: Saunders. pp. 1194–95. 4677: 4375:"Influencing self-management: from compliance to collaboration" 1885: 1678: 1674: 1530: 963: 939: 867: 843: 782: 779: 341: 170: 8974:(10 ed.). International Diabetes Federation. p. 33. 7600: 5981:
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commenting that he had only seen two cases during his career.
638:
is more common in women than men in many parts of Africa. The
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interventions on disease progression are not established. A
930:, and fat tissue. In the liver, insulin normally suppresses 356:, and poor blood flow in the lower-limbs, which may lead to 10283: 9786: 6624: 6583: 5249:
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5242: 4596:"Low testosterone and the association with type 2 diabetes" 3001: 2409: 2362: 1855:, an inhibitor of the renin-angiotensin system (such as an 955: 767: 98: 86: 83: 7273: 6397: 6093: 6039: 5781: 4766: 3107: 1308:
testing may be useful to confirm type 1 diabetes and
7232: 6982:"Achieving Type 2 Diabetes Remission through Weight Loss" 6782:
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6245: 5882: 5400: 4553:
The Journal of Steroid Biochemistry and Molecular Biology
3434: 1586:< 6%) as opposed to standard blood sugar lowering (HbA 1161:
fasting plasma glucose ≥ 7.0 mmol/L (126 mg/dL)
774:
is estimated at 72%. More than 36 genes and 80 
605:. Other complications include hyperpigmentation of skin ( 518:
The classic symptoms of diabetes are frequent urination (
9194:
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558:(a condition of very high blood sugar associated with a 9134: 6887: 3144: 2870:
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8757:
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3536:"Type 2 Diabetes Mellitus: A Review of Current Trends" 2287: 1717:‐based interventions for adults with type 2 diabetes. 1610:. There is moderate evidence suggesting that treating 398:. In type 1 diabetes, there is a lower total level of 9250: 9248: 9193: 9135:
Vipin VA, Blesson CS, Yallampalli C (15 March 2022).
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6830: 5006: 4887: 4019: 3533: 3110:"The Main Events in the History of Diabetes Mellitus" 514:
Overview of the most significant symptoms of diabetes
371:
Type 2 diabetes primarily occurs as a result of
101: 9445: 8582:
The Journal of Clinical Endocrinology and Metabolism
7859:
Therapeutic Advances in Endocrinology and Metabolism
7559: 6340:"Type 2 diabetes: The management of type 2 diabetes" 6252:
The Journal of Clinical Endocrinology and Metabolism
5441: 2959:
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1374:
with diabetes, ethnicity at high risk for diabetes,
966:, and inappropriate regulation of metabolism by the 818:
regulation may have a role in type 2 diabetes.
386:
Type 2 diabetes makes up about 90% of cases of
95: 89: 80: 5701: 5699: 5495:"Diabetes: putting people at the heart of services" 5202:"Diagnosis and classification of diabetes mellitus" 5089:"Diagnosis and classification of diabetes mellitus" 3534:Olokoba AB, Obateru OA, Olokoba LB (July 7, 2012). 3116:(2nd ed.). New York: Springer. pp. 3–16. 3062:(2nd ed.). Boca Raton: CRC Press. p. 25. 2569: 2100:is a first line treatment in type 2 diabetes. 9245: 8320: 7226: 6922: 6298:Nutrition, Metabolism, and Cardiovascular Diseases 5610: 5274: 4808: 4452: 4336:National Diabetes Information Clearinghouse (NDIC) 882:may also interact with type 2 diabetes, with 414:. Diagnosis of diabetes is by blood tests such as 64:A blue circle is the universal symbol of diabetes. 9016: 8750: 8218: 8169: 5746: 3108:Zajac J, Shrestha A, Patel P, Poretsky L (2009). 2819:Ganguly S, Tan HC, Lee PC, Tham KW (April 2015). 2818: 10347: 10017:Metabolic Score for Insulin Resistance (METS-IR) 9441:ADA's Standards of Medical Care in Diabetes 2024 8361: 7038:American Diabetes Association (1 January 2021). 6831:Thomas DE, Elliott EJ, Naughton GA (July 2006). 5696: 5394: 5305: 3639: 3487:"Dietary fats and prevention of type 2 diabetes" 3480: 2290:African Journal of Medicine and Medical Sciences 2235: 1831:, insulin is generally the treatment of choice. 922:. Insulin resistance, which is the inability of 8469: 8467: 8465: 8362:Zheng SL, Roddick AJ, Ayis S (September 2017). 6143: 6141: 6139: 4888:Reed J, Bain S, Kanamarlapudi V (August 2021). 4838: 4836: 4372: 3771: 3319: 3053: 2952: 2685:(9th ed.). New York: McGraw-Hill Medical. 1599:less than nine years who will not benefit, are 658:have been connected with type 2 diabetes. 9326: 9324: 7738: 7736: 7504: 7085: 7083: 6923:Magkos F, Hjorth MF, Astrup A (October 2020). 5251:Robbins and Cotran Pathologic Basis of Disease 5200:American Diabetes Association (January 2012). 5087:American Diabetes Association (January 2010). 4220: 4218: 3103: 3101: 3099: 3097: 3095: 3093: 3091: 3089: 3087: 2683:Greenspan's basic & clinical endocrinology 2680: 2323: 2321: 2319: 2317: 2315: 2313: 2311: 2050:. The disease was rare during the time of the 1759:European Association for the Study of Diabetes 1201:European Association for the Study of Diabetes 878:is also associated with type 2 diabetes. 50:noninsulin-dependent diabetes mellitus (NIDDM) 9802: 9587: 8798: 8796: 7142: 6890:The Mount Sinai Journal of Medicine, New York 6089: 6087: 6085: 5347: 5345: 5343: 5341: 5339: 5142: 5140: 5138: 5136: 5134: 5132: 5033: 5031: 5029: 4368: 4366: 4276:"The genetic architecture of type 2 diabetes" 3970: 2676: 2674: 2672: 2670: 2668: 2565: 2563: 2198: 2196: 2194: 2192: 2190: 736:appears to play a role in increasing risk. A 9006:(14 ed.). Elsevier. pp. 1349–1370. 8462: 8409: 8407: 8261: 8010: 7961:"Rosiglitazone for type 2 diabetes mellitus" 7005: 7003: 6716: 6332: 6136: 5312:Basic Skills in Interpreting Laboratory Data 5038:International Expert Committee (July 2009). 4833: 4671: 4587: 4544: 4453:Sampson UK, Linton MF, Fazio S (July 2011). 4062: 3823: 3819: 3817: 3249: 2666: 2664: 2662: 2660: 2658: 2656: 2654: 2652: 2650: 2648: 2537: 2535: 2533: 2531: 2529: 2527: 2525: 2523: 2463: 1329:United States Preventive Services Task Force 954:levels in the blood, increased retention of 502:in the disease was determined in the 1920s. 9321: 9082:International Journal of Molecular Sciences 8753:"Bariatric surgery for diabetes management" 8045:The Cochrane Database of Systematic Reviews 7968:The Cochrane Database of Systematic Reviews 7733: 7462:The Cochrane Database of Systematic Reviews 7365: 7149:The Cochrane Database of Systematic Reviews 7080: 6837:The Cochrane Database of Systematic Reviews 6729:The Cochrane Database of Systematic Reviews 6673: 6524: 6100:The Cochrane Database of Systematic Reviews 5980: 5835:The Cochrane Database of Systematic Reviews 5660:The Cochrane Database of Systematic Reviews 5489: 5487: 5448:The Cochrane Database of Systematic Reviews 5442:Peer N, Balakrishna Y, Durao S (May 2020). 4707: 4594:Farrell JB, Deshmukh A, Baghaie AA (2008). 4224: 4215: 3971:Hu EA, Pan A, Malik V, Sun Q (March 2012). 3084: 2770:The Cochrane Database of Systematic Reviews 2716:The Cochrane Database of Systematic Reviews 2521: 2519: 2517: 2515: 2513: 2511: 2509: 2507: 2505: 2503: 2308: 1653:Several diets may be effective such as the 1359:. Screening can be repeated every 3 years. 9809: 9795: 9594: 9580: 9436:Centers for Disease Control and Prevention 9187: 8965:International Diabetes Federation (2021). 8793: 8219:Brunström M, Carlberg B (September 2019). 7372:The American Journal of Clinical Nutrition 6082: 5336: 5129: 5026: 4846:Seminars in Cell and Developmental Biology 4550: 4363: 4231:European Journal of Clinical Investigation 3476: 3474: 3202: 3200: 3198: 3196: 3194: 3192: 3190: 3188: 3186: 3184: 3049: 3047: 2909: 2905: 2903: 2901: 2618: 2560: 2236:Pasquel FJ, Umpierrez GE (November 2014). 2187: 2142: 1834: 1478:, when compared to diet and exercise or a 9759:Other pancreatic disorders and conditions 9364: 9280: 9211: 9170: 9152: 9111: 9093: 9052: 9034: 8941: 8768: 8727: 8717: 8642: 8593: 8552: 8491: 8445: 8435: 8404: 8387: 8338: 8285: 8244: 8195: 8170:Brunström M, Carlberg B (February 2016). 8146: 8105: 8064: 7987: 7935: 7886: 7829: 7760: 7669: 7659: 7618: 7585: 7481: 7424: 7383: 7342: 7250: 7209: 7168: 7107: 7055: 7000: 6856: 6807: 6758: 6748: 6699: 6650: 6601: 6548: 6464: 6415: 6374: 6271: 6222: 6173: 6119: 6057: 6016: 6006: 5957: 5908: 5809: 5799: 5723: 5679: 5587: 5467: 5418: 5369: 5277:Diabetes mellitus a guide to patient care 5225: 5164: 5112: 5063: 4915: 4905: 4811:Diabetes mellitus a guide to patient care 4784: 4743: 4611: 4527: 4504:"Diabetes and cancer: a consensus report" 4478: 4307: 4242: 4198: 4149: 4094: 4045: 3996: 3947: 3898: 3841: 3814: 3797: 3657: 3616: 3597:Bulletin of the World Health Organization 3567: 3510: 3027: 2978: 2844: 2645: 2595: 2459: 2457: 2437: 2427: 2405: 2403: 2358: 2356: 2354: 2283: 2281: 2261: 2231: 2229: 2140: 2138: 2136: 2134: 2132: 2130: 2128: 2126: 2124: 2122: 1187:) of ≥ 48 mmol/mol (≥ 6.5 472:often improves diabetes in those who are 8751:Frachetti KJ, Goldfine AB (April 2009). 8368:Diabetes & Vascular Disease Research 5568:The Lancet. Diabetes & Endocrinology 5484: 5444:"Screening for type 2 diabetes mellitus" 4174: 4131: 3778:The Lancet. Diabetes & Endocrinology 3346: 3315: 3313: 3311: 3309: 3307: 3305: 3303: 3301: 3299: 3297: 2500: 1956:Prevalence of total diabetes by age and 1951: 1865:angiotensin converting enzyme inhibitors 1724: 1413:or socioeconomic effects are not clear. 1212:ADA diabetes diagnostic criteria   899: 700:. Among those who are not obese, a high 509: 9309:Faculty of Biology, Medicine and Health 8837: 7699:The Lancet Diabetes & Endocrinology 7566:Cochrane Database of Systematic Reviews 6881: 6833:"Exercise for type 2 diabetes mellitus" 6487: 6154:Cochrane Database of Systematic Reviews 5925: 5775: 5725:10.7326/0003-4819-159-8-201310150-00007 4986:10.7326/0003-4819-152-5-201003020-01003 4932: 4639:(Systematic review and meta-analysis). 3866: 3739:Diabetes Research and Clinical Practice 3471: 3282:Faculty of Biology, Medicine and Health 3221:10.7326/0003-4819-152-5-201003020-01003 3181: 3044: 2898: 2204:"Diagnosis of Diabetes and Prediabetes" 990:WHO diabetes diagnostic criteria   14: 10348: 9234: 5000: 4842: 3640:Christian P, Stewart CP (March 2010). 2867: 2707: 2454: 2400: 2351: 2278: 2226: 2119: 1784:Other classes of medications include: 1771:atherosclerotic cardiovascular disease 1733: 1713:is under way to assess the effects of 1693:may be useful in those with diabetes. 1689:can help reducing the effects of T2D. 390:, with the other 10% due primarily to 10366:Medical conditions related to obesity 9790: 9575: 9337:BMJ Open Diabetes Research & Care 9241:. OrangeBooks Publication. p. 2. 8673:(Plain English summary). 2020-10-21. 8418:, Ridao M, et al. (March 2016). 4971: 3294: 3206: 1474:found moderate-quality evidence that 1263:Random glucose with classic symptoms 821: 732:decreasing the risk. Eating a lot of 505: 10059:Metabolic assessment and monitoring 9017:Olaogun I, Farag M, Hamid P (2020). 6674:Makam AN, Nguyen OK (January 2017). 5749:The Medical Clinics of North America 4377:. In Bethel MN, Feinglos MA (eds.). 3830:Cleveland Clinic Journal of Medicine 3826:"Does lack of sleep cause diabetes?" 2953:Tfayli H, Arslanian S (March 2009). 2339:from the original on 2 February 2016 1700: 802:maturity onset diabetes of the young 766:Most cases of diabetes involve many 402:to control blood glucose, due to an 10335:Notable people with type 1 diabetes 9847:(SIDD, SIRD, MOD and MARD clusters) 7241:(Professional society guidelines). 6633:(Professional society guidelines). 4510:(Professional society guidelines). 1687:microbiota-accessible carbohydrates 1582:Intensive blood sugar lowering (HbA 668:Lifestyle causes of type 2 diabetes 24: 9004:Williams Textbook of Endocrinology 4724:Diabetes, Obesity & Metabolism 4117:: CS1 maint: overridden setting ( 3824:Touma C, Pannain S (August 2011). 2544:Williams textbook of endocrinology 893: 798:"other specific types of diabetes" 740:is believed to cause 7% of cases. 597:through disease processes such as 406:induced loss of insulin-producing 25: 10377: 10289:International Diabetes Federation 9419: 6692:10.1161/CIRCULATIONAHA.116.022622 5308:"Chapter 13: Endocrine Disorders" 3891:10.1161/CIRCULATIONAHA.109.876185 1966:International Diabetes Federation 1794:dipeptidyl peptidase-4 inhibitors 1197:International Diabetes Federation 758:Genetic causes of type 2 diabetes 10165:Hyperosmolar hyperglycemic state 9381: 9297: 9261:The American Journal of Medicine 9228: 9128: 9069: 9010: 8995: 8958: 8917: 8874: 8831: 8744: 8693: 8659: 8610: 8569: 8520: 8355: 8314: 8212: 8163: 8122: 8081: 8032: 8004: 7952: 7903: 7846: 7789: 7686: 7635: 7594: 7553: 7498: 7449: 7400: 7359: 7310: 7267: 7185: 7136: 7031: 6974: 6916: 6824: 6775: 6667: 6618: 6577: 6346:from the original on 2015-05-22. 5938:European Journal of Epidemiology 5306:Vivian EM, Blackorbay B (2013). 4373:Funnell MM, Anderson RM (2008). 4244:10.1111/j.1365-2362.2010.02454.x 4187:Twin Research and Human Genetics 4151:10.1111/j.1365-2796.2012.02536.x 4075:European Journal of Epidemiology 3159:10.1136/postgradmedj-2015-133281 2478:10.2165/00003495-200565030-00005 1406:are also recommended screening. 846:. Those who have previously had 569: 560:decreased level of consciousness 556:hyperosmolar hyperglycemic state 362:hyperosmolar hyperglycemic state 159:Hyperosmolar hyperglycemic state 76: 55: 6481: 6432: 6417:10.1001/archinternmed.2012.3147 6391: 6350: 6288: 6239: 6215:10.1001/jamainternmed.2017.6040 6190: 6033: 5974: 5876: 5826: 5740: 5647: 5604: 5555: 5521: 5435: 5299: 5267: 5193: 5080: 4965: 4881: 4801: 4760: 4628: 4495: 4446: 4403: 4353: 4342:from the original on 2008-07-04 4324: 4267: 4225:Herder C, Roden M (June 2011). 4125: 4013: 3964: 3915: 3765: 3729: 3674: 3633: 3584: 3527: 3428: 3417:from the original on 2024-03-19 3399: 3375: 3340: 3270: 3243: 3138: 3114:Principles of diabetes mellitus 3060:Exercise and disease management 3054:Leutholtz BC, Ripoll I (2011). 2995: 2971:10.1590/s0004-27302009000200008 2946: 2861: 2812: 2757: 2623:. Academic Press. p. 575. 2619:MacKay I, Rose N, eds. (2014). 2612: 2416:World Journal of Clinical Cases 1941: 1378:≥130/80 mmHg or on therapy for 776:single nucleotide polymorphisms 632:Generous consumption of alcohol 8712:(41): 1–190, 215–357, iii–iv. 8340:10.1001/jamainternmed.2014.348 8057:10.1002/14651858.CD006383.pub2 7980:10.1002/14651858.CD006063.pub2 7505:Hackett RA, Steptoe A (2017). 7474:10.1002/14651858.CD006424.pub3 7161:10.1002/14651858.CD006296.pub2 6849:10.1002/14651858.CD002968.pub2 6741:10.1002/14651858.CD004714.pub4 6166:10.1002/14651858.CD005061.pub3 6112:10.1002/14651858.CD008558.pub2 5843:10.1002/14651858.CD005102.pub2 5672:10.1002/14651858.CD003054.pub4 5460:10.1002/14651858.cd005266.pub2 2825:Journal of Biomedical Research 2782:10.1002/14651858.CD005060.pub3 2743:10.1002/14651858.CD002966.pub4 2724:10.1002/14651858.CD002966.pub3 2169: 1720: 1621: 762:Epigenetics of diabetes type 2 13: 1: 10224:Diabetes-related skin disease 9766:Pancreatic beta cell function 8895:10.1016/S0140-6736(12)60401-2 7711:10.1016/S2213-8587(20)30343-0 6490:Current Opinion in Cardiology 6404:Archives of Internal Medicine 6059:10.1016/S0140-6736(18)31809-9 5580:10.1016/S2213-8587(21)00088-7 4459:Current Opinion in Cardiology 4412:Expert Opinion on Drug Safety 4132:Lind L, Lind PM (June 2012). 4038:10.1016/S0140-6736(12)61031-9 3790:10.1016/S2213-8587(15)00316-2 3751:10.1016/j.diabres.2010.04.012 3503:10.1016/j.plipres.2008.10.002 3361:10.1016/S1262-3636(10)70475-4 2588:10.1016/S0140-6736(16)31678-6 2177:"Diabetes Blue Circle Symbol" 2154:. August 2011. Archived from 2112: 2028: 1869:angiotensin receptor blockers 1755:American Diabetes Association 1744:There are several classes of 1729:Metformin 500 mg tablets 1551: 1451:Prevention of type 2 diabetes 1444: 1364:American Diabetes Association 1203:(EASD) recommended that a HbA 1193:American Diabetes Association 746:Persistent organic pollutants 550:. Other symptoms may include 484: 10022:Homeostatic model assessment 9816: 9273:10.1016/j.amjmed.2019.08.035 8770:10.1097/MED.0b013e32832912e7 8706:Health Technology Assessment 8437:10.1371/journal.pmed.1001971 8148:10.1016/j.gheart.2019.07.009 8094:Health Technology Assessment 7661:10.1371/journal.pmed.1001204 7511:Nature Reviews Endocrinology 6929:Nature Reviews Endocrinology 6502:10.1097/HCO.0b013e328347b139 6310:10.1016/j.numecd.2021.10.005 6008:10.1371/journal.pone.0093471 4980:(5): ITC31-15, quiz ITC316. 4859:10.1016/j.semcdb.2019.12.002 4471:10.1097/HCO.0b013e3283470359 4138:Journal of Internal Medicine 3215:(5): ITC31–15, quiz ITC316. 3147:Postgraduate Medical Journal 1861:angiotensin receptor blocker 1843:In people with diabetes and 1667:monitored carbohydrate diets 1499:alpha-glucosidase inhibitors 1370:) with another risk factor: 1315: 1233:≥ 6.5% (≥ 48 mmol/mol) 984: 946:, resistance to and lack of 661: 324:. Symptoms may also include 7: 10007:Noninvasive glucose monitor 8486:(Supplement_1): S179–S218. 8280:(Supplement_1): S219–S230. 8237:10.1136/bmjopen-2018-026686 7802:Annals of Internal Medicine 7755:(Supplement_1): S158–S178. 7288:10.11124/JBISRIR-D-19-00397 7245:(Supplement_1): S120–S143. 7050:(Supplement_1): S100–S110. 6590:Annals of Internal Medicine 6543:(Supplement_1): S111–S125. 5712:Annals of Internal Medicine 5407:Annals of Internal Medicine 5007:World Health Organization. 4974:Annals of Internal Medicine 4565:10.1016/j.jsbmb.2008.12.022 4455:"Are statins diabetogenic?" 3250:Rathee M, Prachi J (2019). 3209:Annals of Internal Medicine 2366:Annals of Internal Medicine 2210:. June 2014. Archived from 2148:"Diabetes Fact sheet N°312" 2103: 1979:Some ethnic groups such as 1626: 1525:, no intervention improved 1513:(HbA1c). It was found that 751: 420:oral glucose tolerance test 232:Maintaining normal weight, 10: 10382: 10239:Diabetic cheiroarthropathy 10068:Ambulatory glucose profile 9875:Impaired glucose tolerance 9750:Rabson–Mendenhall syndrome 9743:Congenital hyperinsulinism 9349:10.1136/bmjdrc-2019-000962 7102:(Supplement_1): S77–S110. 5761:10.1016/j.mcna.2011.06.007 5507:10.3310/nihrevidence_52026 4693:10.1152/ajpendo.00421.2006 3491:Progress in Lipid Research 3407:"WHAT IS TYPE 2 DIABETES?" 2020: 2016: 1945: 1921: 1737: 1639: 1555: 1465:impaired glucose tolerance 1448: 1299:cells in the pancreas and 1279:and complications such as 1236:5.7–6.4% (39–47 mmol/mol) 1103:Impaired glucose tolerance 1078:Impaired fasting glycaemia 810:Rabson–Mendenhall syndrome 755: 665: 646:. The intestinal bacteria 573: 466:continuous glucose monitor 383:more at risk than others. 308:. Common symptoms include 10356:Aging-associated diseases 10307: 10264: 10140: 10045: 9987:Postprandial glucose test 9957: 9824: 9758: 9722: 9683: 9614: 9534: 9449: 9213:10.2337/diacare.27.5.1047 9141:World Journal of Diabetes 8635:10.1136/bmjqs-2019-010581 7578:10.1002/14651858.CD014881 7211:10.1016/j.nut.2014.06.011 6941:10.1038/s41574-020-0381-5 6800:10.1007/s00125-016-4079-0 5950:10.1007/s10654-017-0246-y 5159:(Supplement_1): S20–S42. 4949:World Health Organization 4649:10.1007/s11892-017-0949-1 4424:10.1517/14740338.4.6.1097 4087:10.1007/s10654-018-0380-1 3349:Diabetes & Metabolism 3322:American Family Physician 3258:. StatPearls Publishing. 2152:World Health Organization 2011:World Health Organization 1915:electronic health records 1746:anti-diabetic medications 1691:Viscous fiber supplements 1392:polycystic ovary syndrome 1357:polycystic ovary syndrome 1155:World Health Organization 1053: 1008: 1005: 1002: 724:increasing the risk, and 682:lack of physical activity 624: 576:Complications of diabetes 328:, having a sensation of 296:that is characterized by 271: 258: 240: 228: 218: 204: 196: 188: 152: 128: 116: 68: 63: 54: 46:Diabetes mellitus type 2; 42: 37: 27:Form of diabetes mellitus 10325:Epidemiology of diabetes 10063:Blood glucose monitoring 9939:Type 3c (pancreatogenic) 9870:Impaired fasting glucose 8852:10.3810/pgm.2011.01.2242 8623:BMJ Quality & Safety 8380:10.1177/1479164117715854 7871:10.1177/2042018820980225 4637:Current Diabetes Reports 4613:10.1177/0145721708323100 3646:The Journal of Nutrition 3485:, Hu FB (January 2009). 1958:Global Burden of Disease 1948:Epidemiology of diabetes 1879: 1616:scaling and root planing 1535:congestive heart failure 1501:in people with impaired 886:increasing the risk and 744:is another risk factor. 18:Diabetes mellitus type 2 10182:Neuropathic arthropathy 9426:IDF Diabetes Atlas 2021 9238:A Hand Book On Diabetes 9235:Sajida S (2021-01-26). 8014:Chinese Medical Journal 6376:10.1001/jama.2014.18574 5613:Evidence-Based Medicine 5371:10.1001/jama.2021.12531 5099:(Supplement_1): S62-9. 4786:10.1111/1753-0407.13525 3112:. In Poretsky L (ed.). 2837:10.7555/JBR.29.20140127 2621:The Autoimmune Diseases 2429:10.12998/wjcc.v3.i6.504 1888:in diabetes to prevent 1835:Blood pressure lowering 1802:GLP-1 receptor agonists 1635: 1511:glycated hemoglobin A1c 1497:assessed the effect of 1398:. People with previous 1345:people of Asian descent 876:Testosterone deficiency 840:atypical antipsychotics 634:is also a risk factor. 304:, and relative lack of 10130:Gastric bypass surgery 10012:Insulin tolerance test 9982:Glucose tolerance test 9887:Ketosis-prone diabetes 9858:Diabetes and pregnancy 9154:10.4239/wjd.v13.i3.185 8327:JAMA Internal Medicine 7928:10.1001/jama.2018.3024 7620:10.1001/jama.2016.9400 7523:10.1038/nrendo.2017.64 7276:JBI Evidence Synthesis 6203:JAMA Internal Medicine 3843:10.3949/ccjm.78a.10165 1961: 1890:cardiovascular disease 1853:chronic kidney disease 1779:chronic kidney disease 1763:GLP-1 receptor agonist 1730: 1384:cardiovascular disease 1266:≥ 200 mg/dL 1255:≥ 200 mg/dL 1244:≥ 126 mg/dL 1208:(>200 mg/dL). 1173:glucose tolerance test 968:central nervous system 911: 748:may also play a role. 714:sugar-sweetened drinks 583:ischemic heart disease 515: 416:fasting plasma glucose 360:. The sudden onset of 348:, which can result in 8840:Postgraduate Medicine 8729:10536/DRO/DU:30064294 8595:10.1210/jc.2017-01024 4600:The Diabetes Educator 3659:10.3945/jn.109.116327 3609:10.2471/BLT.12.113415 3413:. December 29, 2021. 2737:(Retracted, see 2021:Further information: 1955: 1946:Further information: 1812:Injections of insulin 1728: 1671:low carbohydrate diet 1640:Further information: 1556:Further information: 1539:myocardial infarction 1507:fasting blood glucose 1372:first-degree relative 903: 796:forms of diabetes or 680:of greater than 25), 615:diabetic ketoacidosis 591:cognitive dysfunction 540:peripheral neuropathy 526:), increased hunger ( 522:), increased thirst ( 513: 288:), formerly known as 163:diabetic ketoacidosis 48:adult-onset diabetes; 10320:Glossary of diabetes 10279:Open Insulin Project 10115:Embryonic stem cells 9852:Gestational diabetes 9095:10.3390/ijms24010658 7865:: 2042018820980225. 7385:10.1093/ajcn/nqaa435 6264:10.1210/jc.2014-2136 5625:10.1136/ebm.13.6.173 4951:. 2006. p. 21. 4907:10.2147/DMSO.S319895 3540:Oman Medical Journal 2582:(10053): 1545–1602. 2329:"Causes of Diabetes" 2048:Apollonius Memphites 1960:super-region in 2021 1564:blood glucose levels 1400:gestational diabetes 1353:gestational diabetes 1301:gestational diabetes 848:gestational diabetes 686:psychological stress 655:Bacteroides vulgatus 607:acanthosis nigricans 396:gestational diabetes 364:may occur; however, 346:diabetic retinopathy 290:adult-onset diabetes 211:, lack of exercise, 175:diabetic retinopathy 10330:History of diabetes 10315:Outline of diabetes 10244:Diabetic foot ulcer 10229:Diabetic dermopathy 10188:Organs in diabetes 10120:Artificial pancreas 10080:Diabetes medication 9977:Glycated hemoglobin 9401:10.3310/alert_40652 9036:10.7759/cureus.7614 8817:10.4158/EP09170.RAR 8679:10.3310/alert_42103 6988:. 30 September 2020 5999:2014PLoSO...993471X 5541:10.3310/alert_48878 5212:(Suppl 1): S64-71. 4773:Journal of Diabetes 4300:10.1038/nature18642 4292:2016Natur.536...41F 4200:10.1017/thg.2015.83 3707:10.1038/nature18646 3699:2016Natur.535..376P 3552:10.5001/omj.2012.68 3355:(Suppl 3): S100-5. 2023:History of diabetes 1927:Weight loss surgery 1740:Diabetes medication 1734:Blood sugar control 1647:Calorie restriction 1558:Diabetes management 1527:all-cause mortality 1388:physical inactivity 1258:140–199 mg/dL 1247:100–125 mg/dL 1213: 1181:glycated hemoglobin 996: 907:Disposition metrics 742:Sedentary lifestyle 730:monounsaturated fat 599:Alzheimer's disease 448:Treatment involves 424:glycated hemoglobin 192:Middle or older age 10294:World Diabetes Day 9882:Insulin resistance 9733:Insulin resistance 9608:glucose metabolism 9535:External resources 8968:IDF Diabetes Atlas 8805:Endocrine Practice 6052:(10170): 434–445. 5310:. In Lee M (ed.). 3449:10.1002/lary.24354 1962: 1901:primary prevention 1790:thiazolidinediones 1761:recommend using a 1731: 1659:Mediterranean diet 1219:Diabetes mellitus 1211: 989: 920:insulin resistance 918:in the setting of 912: 856:Cushing's syndrome 822:Medical conditions 611:sexual dysfunction 564:low blood pressure 544:vaginal infections 516: 506:Signs and symptoms 462:insulin injections 379:. Some people are 314:frequent urination 302:insulin resistance 275:392 million (2015) 139:frequent urination 10361:Types of diabetes 10343: 10342: 10037:Disposition index 9967:Blood sugar level 9837:Type 1 diabetes ( 9784: 9783: 9673:Template:Diabetes 9569: 9568: 8981:978-2-930229-98-0 8943:10.2337/dc16-0236 8889:(9833): 2300–11. 8629:(12): 1019–1032. 8545:10.2337/dc10-0555 8493:10.2337/dc24-S010 8287:10.2337/dc24-S011 7922:(15): 1580–1591. 7808:(10): 1392–1400. 7762:10.2337/dc24-S011 7426:10.2337/dc18-1126 7335:10.2337/dc12-9002 7252:10.2337/dc14-S120 7109:10.2337/dc24-S005 7057:10.2337/dc21-S008 6902:10.1002/msj.20118 6794:(12): 2527–2545. 6643:10.2337/dc12-2480 6550:10.2337/dc24-S006 6457:10.1136/bmj.d4169 6410:(17): 1296–1303. 6209:(12): 1808–1817. 5901:10.1136/bmj.c4229 5801:10.1136/bmj.i3857 5321:978-1-58528-345-3 5292:978-1-58255-732-8 5260:978-0-7216-0187-8 5218:10.2337/dc12-s064 5166:10.2337/dc24-S002 5105:10.2337/dc10-S062 5056:10.2337/dc09-9033 4958:978-92-4-159493-6 4826:978-1-58255-732-8 4736:10.1111/dom.13005 4520:10.2337/dc10-0666 4388:978-1-58829-794-5 3989:10.1136/bmj.e1454 3940:10.2337/dc10-1079 3123:978-0-387-09840-1 3069:978-1-4398-2759-8 3020:10.2337/dc12-0669 2924:10.1038/nm0106-75 2883:978-1-4496-4660-8 2692:978-0-07-162243-1 2630:978-0-12-384929-8 2553:978-1-4377-0324-5 2254:10.2337/dc14-0984 2183:on 5 August 2007. 2158:on 26 August 2013 2079:Frederick Banting 1985:Pacific Islanders 1929:in those who are 1707:stress management 1701:Stress management 1503:glucose tolerance 1495:systematic review 1472:systematic review 1426:African-Caribbean 1339:over 25) or have 1273: 1272: 1151: 1150: 1128:Diabetes mellitus 995: 975:disposition index 800:). These include 722:trans fatty acids 698:Pacific Islanders 603:vascular dementia 470:Bariatric surgery 294:diabetes mellitus 279: 278: 253:bariatric surgery 220:Diagnostic method 32:Medical condition 16:(Redirected from 10373: 10075:Diet in diabetes 9811: 9804: 9797: 9788: 9787: 9700:Oxyhyperglycemia 9596: 9589: 9582: 9573: 9572: 9447: 9446: 9413: 9412: 9385: 9379: 9378: 9368: 9328: 9319: 9318: 9316: 9315: 9301: 9295: 9294: 9284: 9252: 9243: 9242: 9232: 9226: 9225: 9215: 9191: 9185: 9184: 9174: 9156: 9132: 9126: 9125: 9115: 9097: 9073: 9067: 9066: 9056: 9038: 9014: 9008: 9007: 8999: 8993: 8992: 8990: 8988: 8973: 8962: 8956: 8955: 8945: 8921: 8915: 8914: 8878: 8872: 8871: 8835: 8829: 8828: 8800: 8791: 8790: 8772: 8748: 8742: 8741: 8731: 8721: 8719:10.3310/hta13410 8697: 8691: 8690: 8663: 8657: 8656: 8646: 8614: 8608: 8607: 8597: 8588:(9): 3097–3110. 8573: 8567: 8566: 8556: 8524: 8518: 8517: 8508: 10725811. 8495: 8471: 8460: 8459: 8449: 8439: 8411: 8402: 8401: 8391: 8359: 8353: 8352: 8342: 8318: 8312: 8311: 8302: 10725805. 8289: 8265: 8259: 8258: 8248: 8216: 8210: 8209: 8199: 8188:10.1136/bmj.i717 8167: 8161: 8160: 8150: 8126: 8120: 8119: 8109: 8107:10.3310/hta14360 8085: 8079: 8078: 8068: 8036: 8030: 8029: 8008: 8002: 8001: 7991: 7965: 7956: 7950: 7949: 7939: 7907: 7901: 7900: 7890: 7850: 7844: 7843: 7833: 7814:10.7326/M21-2941 7793: 7787: 7786: 7777: 10725810. 7764: 7740: 7731: 7730: 7690: 7684: 7683: 7673: 7663: 7639: 7633: 7632: 7622: 7598: 7592: 7591: 7589: 7572:(12): CD014881. 7557: 7551: 7550: 7502: 7496: 7495: 7485: 7453: 7447: 7446: 7428: 7404: 7398: 7397: 7387: 7378:(6): 1515–1530. 7363: 7357: 7356: 7346: 7329:(8): 1798–1808. 7314: 7308: 7307: 7271: 7265: 7264: 7254: 7230: 7224: 7223: 7213: 7189: 7183: 7182: 7172: 7140: 7134: 7133: 7124: 10725816. 7111: 7087: 7078: 7077: 7059: 7035: 7029: 7028: 7026: 7024: 7019:. September 2023 7007: 6998: 6997: 6995: 6993: 6978: 6972: 6971: 6920: 6914: 6913: 6885: 6879: 6878: 6860: 6828: 6822: 6821: 6811: 6779: 6773: 6772: 6762: 6752: 6720: 6714: 6713: 6703: 6671: 6665: 6664: 6654: 6637:(5): 1384–1395. 6622: 6616: 6615: 6605: 6603:10.7326/M17-0939 6581: 6575: 6574: 6565: 10725808. 6552: 6528: 6522: 6521: 6485: 6479: 6478: 6468: 6436: 6430: 6429: 6419: 6395: 6389: 6388: 6378: 6354: 6348: 6347: 6336: 6330: 6329: 6292: 6286: 6285: 6275: 6243: 6237: 6236: 6226: 6194: 6188: 6187: 6177: 6160:(12): CD005061. 6145: 6134: 6133: 6123: 6106:(12): CD008558. 6091: 6080: 6079: 6061: 6037: 6031: 6030: 6020: 6010: 5978: 5972: 5971: 5961: 5929: 5923: 5922: 5912: 5880: 5874: 5873: 5870: 5830: 5824: 5823: 5813: 5803: 5779: 5773: 5772: 5744: 5738: 5737: 5727: 5703: 5694: 5693: 5683: 5666:(12): CD003054. 5651: 5645: 5644: 5608: 5602: 5601: 5591: 5559: 5553: 5552: 5525: 5519: 5518: 5491: 5482: 5481: 5471: 5439: 5433: 5432: 5422: 5420:10.7326/M14-2221 5398: 5392: 5391: 5373: 5349: 5334: 5333: 5303: 5297: 5296: 5280: 5271: 5265: 5264: 5246: 5240: 5239: 5229: 5197: 5191: 5190: 5181: 10725812. 5168: 5144: 5127: 5126: 5116: 5084: 5078: 5077: 5067: 5035: 5024: 5023: 5021: 5020: 5011:. Archived from 5004: 4998: 4997: 4969: 4963: 4962: 4946: 4936: 4930: 4929: 4919: 4909: 4885: 4879: 4878: 4840: 4831: 4830: 4814: 4805: 4799: 4798: 4788: 4764: 4758: 4757: 4747: 4711: 4705: 4704: 4675: 4669: 4668: 4632: 4626: 4625: 4615: 4591: 4585: 4584: 4548: 4542: 4541: 4531: 4514:(7): 1674–1685. 4499: 4493: 4492: 4482: 4450: 4444: 4443: 4418:(6): 1097–1109. 4407: 4401: 4400: 4370: 4361: 4357: 4351: 4350: 4348: 4347: 4328: 4322: 4321: 4311: 4271: 4265: 4264: 4246: 4222: 4213: 4212: 4202: 4178: 4172: 4171: 4153: 4129: 4123: 4122: 4116: 4108: 4098: 4066: 4060: 4059: 4049: 4032:(9838): 219–29. 4017: 4011: 4010: 4000: 3968: 3962: 3961: 3951: 3919: 3913: 3912: 3902: 3870: 3864: 3863: 3845: 3821: 3812: 3811: 3801: 3769: 3763: 3762: 3733: 3727: 3726: 3693:(7612): 376–81. 3678: 3672: 3671: 3661: 3637: 3631: 3630: 3620: 3588: 3582: 3581: 3571: 3531: 3525: 3524: 3514: 3478: 3469: 3468: 3437:The Laryngoscope 3432: 3426: 3425: 3423: 3422: 3403: 3397: 3396: 3394: 3393: 3379: 3373: 3372: 3344: 3338: 3337: 3317: 3292: 3291: 3289: 3288: 3274: 3268: 3267: 3247: 3241: 3240: 3204: 3179: 3178: 3142: 3136: 3135: 3105: 3082: 3081: 3051: 3042: 3041: 3031: 2999: 2993: 2992: 2982: 2950: 2944: 2943: 2907: 2896: 2895: 2865: 2859: 2858: 2848: 2816: 2810: 2809: 2761: 2755: 2754: 2735: 2711: 2705: 2704: 2678: 2643: 2642: 2616: 2610: 2609: 2599: 2567: 2558: 2557: 2539: 2498: 2497: 2461: 2452: 2451: 2441: 2431: 2407: 2398: 2397: 2378:10.7326/M15-2650 2360: 2349: 2348: 2346: 2344: 2325: 2306: 2305: 2285: 2276: 2275: 2265: 2233: 2224: 2223: 2221: 2219: 2200: 2185: 2184: 2173: 2167: 2166: 2164: 2163: 2144: 2069:in 400–500  2033: 2030: 1993:Native Americans 1974:developing world 1798:SGLT2 inhibitors 1642:Diet in diabetes 1608:eye examinations 1577:microalbuminuria 1573:high cholesterol 1281:retinal problems 1241:Fasting glucose 1214: 1210: 1006:Fasting glucose 997: 991: 988: 888:anorexia nervosa 880:Eating disorders 864:pheochromocytoma 806:Donohue syndrome 738:lack of exercise 649:Prevotella copri 587:hospitalizations 489: 486: 377:lack of exercise 330:pins and needles 326:increased hunger 320:and unexplained 310:increased thirst 298:high blood sugar 264:10 year shorter 147:increased hunger 135:Increased thirst 108: 107: 104: 103: 100: 97: 94: 91: 88: 85: 82: 59: 35: 34: 21: 10381: 10380: 10376: 10375: 10374: 10372: 10371: 10370: 10346: 10345: 10344: 10339: 10303: 10274:T1International 10266: 10265:Advocacy & 10260: 10136: 10085:Insulin therapy 10041: 9953: 9820: 9815: 9785: 9780: 9754: 9738:Hyperinsulinism 9718: 9712:Whipple's triad 9679: 9610: 9602:Disease of the 9600: 9570: 9565: 9564: 9530: 9529: 9458: 9422: 9417: 9416: 9387: 9386: 9382: 9329: 9322: 9313: 9311: 9303: 9302: 9298: 9253: 9246: 9233: 9229: 9192: 9188: 9133: 9129: 9074: 9070: 9015: 9011: 9000: 8996: 8986: 8984: 8982: 8971: 8963: 8959: 8922: 8918: 8879: 8875: 8836: 8832: 8801: 8794: 8749: 8745: 8698: 8694: 8665: 8664: 8660: 8615: 8611: 8574: 8570: 8539:(6): 1395–402. 8525: 8521: 8472: 8463: 8430:(3): e1001971. 8412: 8405: 8360: 8356: 8319: 8315: 8266: 8262: 8217: 8213: 8168: 8164: 8127: 8123: 8086: 8082: 8051:(7): CD006383. 8037: 8033: 8009: 8005: 7974:(3): CD006063. 7963: 7957: 7953: 7908: 7904: 7851: 7847: 7794: 7790: 7741: 7734: 7691: 7687: 7654:(4): e1001204. 7640: 7636: 7599: 7595: 7558: 7554: 7503: 7499: 7468:(9): CD006424. 7454: 7450: 7405: 7401: 7364: 7360: 7315: 7311: 7282:(5): 966–1002. 7272: 7268: 7231: 7227: 7190: 7186: 7155:(1): CD006296. 7141: 7137: 7088: 7081: 7036: 7032: 7022: 7020: 7009: 7008: 7001: 6991: 6989: 6980: 6979: 6975: 6935:(10): 545–555. 6921: 6917: 6886: 6882: 6843:(3): CD002968. 6829: 6825: 6780: 6776: 6735:(4): CD004714. 6721: 6717: 6672: 6668: 6623: 6619: 6582: 6578: 6529: 6525: 6486: 6482: 6437: 6433: 6396: 6392: 6355: 6351: 6338: 6337: 6333: 6293: 6289: 6258:(10): 3551–60. 6244: 6240: 6195: 6191: 6146: 6137: 6092: 6083: 6038: 6034: 5979: 5975: 5930: 5926: 5881: 5877: 5871: 5837:(3): CD005102. 5831: 5827: 5780: 5776: 5745: 5741: 5704: 5697: 5652: 5648: 5609: 5605: 5560: 5556: 5527: 5526: 5522: 5493: 5492: 5485: 5454:(6): CD005266. 5440: 5436: 5399: 5395: 5350: 5337: 5322: 5304: 5300: 5293: 5273: 5272: 5268: 5261: 5247: 5243: 5198: 5194: 5145: 5130: 5085: 5081: 5036: 5027: 5018: 5016: 5005: 5001: 4970: 4966: 4959: 4944: 4938: 4937: 4933: 4886: 4882: 4841: 4834: 4827: 4807: 4806: 4802: 4765: 4761: 4712: 4708: 4676: 4672: 4633: 4629: 4592: 4588: 4549: 4545: 4500: 4496: 4451: 4447: 4408: 4404: 4389: 4371: 4364: 4358: 4354: 4345: 4343: 4330: 4329: 4325: 4286:(7614): 41–47. 4272: 4268: 4223: 4216: 4179: 4175: 4130: 4126: 4110: 4109: 4067: 4063: 4018: 4014: 3969: 3965: 3934:(11): 2477–83. 3920: 3916: 3885:(11): 1356–64. 3871: 3867: 3822: 3815: 3770: 3766: 3734: 3730: 3679: 3675: 3638: 3634: 3603:(9): 671–682D. 3589: 3585: 3532: 3528: 3479: 3472: 3433: 3429: 3420: 3418: 3405: 3404: 3400: 3391: 3389: 3381: 3380: 3376: 3345: 3341: 3318: 3295: 3286: 3284: 3276: 3275: 3271: 3248: 3244: 3205: 3182: 3143: 3139: 3124: 3106: 3085: 3070: 3052: 3045: 3014:(12): 2515–20. 3000: 2996: 2951: 2947: 2912:Nature Medicine 2908: 2899: 2884: 2866: 2862: 2817: 2813: 2762: 2758: 2736: 2718:(3): CD002966. 2712: 2708: 2693: 2679: 2646: 2631: 2617: 2613: 2568: 2561: 2554: 2540: 2501: 2462: 2455: 2408: 2401: 2361: 2352: 2342: 2340: 2327: 2326: 2309: 2286: 2279: 2248:(11): 3124–31. 2234: 2227: 2217: 2215: 2214:on 6 March 2016 2202: 2201: 2188: 2175: 2174: 2170: 2161: 2159: 2146: 2145: 2120: 2115: 2106: 2031: 2025: 2019: 1950: 1944: 1936:body mass index 1924: 1882: 1837: 1767:SGLT2 inhibitor 1742: 1736: 1723: 1711:Cochrane review 1703: 1644: 1638: 1629: 1624: 1593: 1589: 1585: 1560: 1554: 1537:, or non-fatal 1453: 1447: 1412: 1368:Asian Americans 1318: 1293:type 1 diabetes 1286: 1278: 1230: 1206: 1199:(IDF), and the 1186: 1012: 1003:2-hour glucose 987: 896: 894:Pathophysiology 890:decreasing it. 884:bulimia nervosa 860:hyperthyroidism 828:glucocorticoids 824: 764: 756:Main articles: 754: 726:polyunsaturated 702:waist–hip ratio 678:body mass index 670: 664: 644:DNA methylation 627: 578: 572: 508: 487: 454:dietary changes 392:type 1 diabetes 292:, is a form of 282:Type 2 diabetes 266:life expectancy 245:Dietary changes 112: 79: 75: 49: 47: 38:Type 2 diabetes 33: 28: 23: 22: 15: 12: 11: 5: 10379: 10369: 10368: 10363: 10358: 10341: 10340: 10338: 10337: 10332: 10327: 10322: 10317: 10311: 10309: 10305: 10304: 10302: 10301: 10296: 10291: 10286: 10281: 10276: 10270: 10268: 10262: 10261: 10259: 10258: 10253: 10248: 10247: 10246: 10241: 10236: 10234:Diabetic bulla 10231: 10221: 10220: 10219: 10214: 10209: 10204: 10199: 10194: 10186: 10185: 10184: 10179: 10169: 10168: 10167: 10162: 10157: 10150:Diabetic comas 10146: 10144: 10138: 10137: 10135: 10134: 10133: 10132: 10124: 10123: 10122: 10117: 10109: 10107:Diabetic shoes 10104: 10103: 10102: 10097: 10092: 10082: 10077: 10072: 10071: 10070: 10065: 10057: 10051: 10049: 10043: 10042: 10040: 10039: 10034: 10029: 10024: 10019: 10014: 10009: 10004: 9999: 9994: 9989: 9984: 9979: 9974: 9969: 9963: 9961: 9955: 9954: 9952: 9951: 9946: 9941: 9936: 9935: 9934: 9929: 9919: 9918: 9917: 9890: 9884: 9879: 9878: 9877: 9872: 9862: 9861: 9860: 9848: 9842: 9835: 9834:(SAID cluster) 9828: 9826: 9822: 9821: 9814: 9813: 9806: 9799: 9791: 9782: 9781: 9779: 9778: 9773: 9768: 9762: 9760: 9756: 9755: 9753: 9752: 9747: 9746: 9745: 9735: 9729: 9727: 9720: 9719: 9717: 9716: 9715: 9714: 9704: 9703: 9702: 9691: 9689: 9681: 9680: 9678: 9677: 9676: 9675: 9664: 9663: 9662: 9639: 9634: 9629: 9620: 9618: 9612: 9611: 9599: 9598: 9591: 9584: 9576: 9567: 9566: 9563: 9562: 9560:article/117853 9551: 9539: 9538: 9536: 9532: 9531: 9528: 9527: 9516: 9505: 9494: 9475: 9459: 9454: 9453: 9451: 9450:Classification 9444: 9443: 9438: 9433: 9428: 9421: 9420:External links 9418: 9415: 9414: 9380: 9343:(1): e000962. 9320: 9296: 9267:(3): 290–296. 9244: 9227: 9206:(5): 1047–53. 9186: 9147:(3): 185–202. 9127: 9068: 9009: 8994: 8980: 8957: 8916: 8873: 8830: 8792: 8743: 8692: 8658: 8609: 8568: 8519: 8461: 8403: 8374:(5): 400–406. 8354: 8333:(5): 773–785. 8313: 8260: 8231:(9): e026686. 8211: 8162: 8141:(3): 215–240. 8121: 8080: 8031: 8020:(23): 4301–6. 8003: 7951: 7902: 7845: 7788: 7732: 7685: 7634: 7593: 7552: 7517:(9): 547–560. 7497: 7448: 7419:(5): 755–766. 7399: 7358: 7309: 7266: 7225: 7184: 7135: 7079: 7030: 6999: 6973: 6915: 6896:(3): 257–268. 6880: 6823: 6774: 6715: 6686:(2): 180–195. 6666: 6617: 6596:(8): 569–576. 6576: 6523: 6480: 6431: 6390: 6369:(6): 603–615. 6349: 6331: 6304:(2): 330–336. 6287: 6238: 6189: 6135: 6081: 6032: 5973: 5944:(5): 363–375. 5924: 5875: 5825: 5774: 5755:(5): 953–969. 5739: 5718:(8): 543–551. 5695: 5646: 5603: 5574:(7): 419–426. 5554: 5520: 5483: 5434: 5413:(11): 765–76. 5393: 5364:(8): 736–743. 5335: 5320: 5298: 5291: 5266: 5259: 5241: 5192: 5128: 5079: 5050:(7): 1327–34. 5025: 4999: 4964: 4957: 4931: 4880: 4832: 4825: 4800: 4759: 4706: 4670: 4627: 4606:(5): 799–806. 4586: 4559:(1–2): 40–43. 4543: 4494: 4465:(4): 342–347. 4445: 4402: 4387: 4362: 4352: 4323: 4266: 4237:(6): 679–692. 4214: 4193:(6): 762–771. 4173: 4124: 4081:(9): 811–829. 4061: 4012: 3963: 3914: 3865: 3813: 3784:(12): 958–67. 3764: 3728: 3673: 3632: 3583: 3546:(4): 269–273. 3526: 3470: 3443:(3): 767–776. 3427: 3411:Diabetes Daily 3398: 3374: 3339: 3293: 3269: 3242: 3180: 3153:(1084): 63–9. 3137: 3122: 3083: 3068: 3043: 2994: 2945: 2897: 2882: 2860: 2811: 2756: 2706: 2691: 2644: 2629: 2611: 2559: 2552: 2499: 2472:(3): 385–411. 2453: 2399: 2372:(11): 740–51. 2350: 2307: 2277: 2225: 2186: 2168: 2117: 2116: 2114: 2111: 2105: 2102: 2093:in the 1940s. 2018: 2015: 1943: 1940: 1923: 1920: 1913:Sharing their 1881: 1878: 1836: 1833: 1735: 1732: 1722: 1719: 1702: 1699: 1637: 1634: 1628: 1625: 1623: 1620: 1591: 1587: 1583: 1553: 1550: 1463:In those with 1449:Main article: 1446: 1443: 1410: 1376:blood pressure 1349:family history 1317: 1314: 1284: 1276: 1271: 1270: 1269:Not available 1267: 1264: 1260: 1259: 1256: 1253: 1249: 1248: 1245: 1242: 1238: 1237: 1234: 1231: 1228: 1224: 1223: 1220: 1217: 1204: 1184: 1177: 1176: 1168: 1167: 1163: 1162: 1149: 1148: 1145: 1142: 1139: 1136: 1133: 1130: 1124: 1123: 1120: 1117: 1114: 1111: 1108: 1105: 1099: 1098: 1095: 1092: 1089: 1086: 1083: 1080: 1074: 1073: 1070: 1067: 1064: 1061: 1058: 1055: 1051: 1050: 1045: 1040: 1035: 1030: 1025: 1020: 1014: 1013: 1010: 1007: 1004: 1001: 986: 983: 895: 892: 866:, and certain 823: 820: 753: 750: 676:(defined by a 666:Main article: 663: 660: 626: 623: 574:Main article: 571: 568: 532:blurred vision 507: 504: 354:kidney failure 277: 276: 273: 269: 268: 262: 256: 255: 242: 238: 237: 236:, healthy diet 230: 226: 225: 222: 216: 215: 206: 202: 201: 198: 194: 193: 190: 186: 185: 179:kidney failure 156: 150: 149: 141:, unexplained 132: 126: 125: 120: 114: 113: 111: 110: 72: 70: 66: 65: 61: 60: 52: 51: 44: 40: 39: 31: 26: 9: 6: 4: 3: 2: 10378: 10367: 10364: 10362: 10359: 10357: 10354: 10353: 10351: 10336: 10333: 10331: 10328: 10326: 10323: 10321: 10318: 10316: 10313: 10312: 10310: 10306: 10300: 10297: 10295: 10292: 10290: 10287: 10285: 10282: 10280: 10277: 10275: 10272: 10271: 10269: 10267:Organizations 10263: 10257: 10254: 10252: 10251:Hyperglycemia 10249: 10245: 10242: 10240: 10237: 10235: 10232: 10230: 10227: 10226: 10225: 10222: 10218: 10215: 10213: 10210: 10208: 10205: 10203: 10200: 10198: 10195: 10193: 10192:Blood vessels 10190: 10189: 10187: 10183: 10180: 10178: 10175: 10174: 10173: 10172:Diabetic foot 10170: 10166: 10163: 10161: 10158: 10156: 10153: 10152: 10151: 10148: 10147: 10145: 10143: 10142:Complications 10139: 10131: 10128: 10127: 10125: 10121: 10118: 10116: 10113: 10112: 10110: 10108: 10105: 10101: 10098: 10096: 10093: 10091: 10088: 10087: 10086: 10083: 10081: 10078: 10076: 10073: 10069: 10066: 10064: 10061: 10060: 10058: 10056: 10053: 10052: 10050: 10048: 10044: 10038: 10035: 10033: 10030: 10028: 10025: 10023: 10020: 10018: 10015: 10013: 10010: 10008: 10005: 10003: 10000: 9998: 9995: 9993: 9990: 9988: 9985: 9983: 9980: 9978: 9975: 9973: 9970: 9968: 9965: 9964: 9962: 9960: 9956: 9950: 9947: 9945: 9942: 9940: 9937: 9933: 9930: 9928: 9925: 9924: 9923: 9920: 9916: 9913: 9910: 9907: 9904: 9901: 9898: 9897: 9895: 9891: 9888: 9885: 9883: 9880: 9876: 9873: 9871: 9868: 9867: 9866: 9863: 9859: 9856: 9855: 9853: 9849: 9846: 9843: 9840: 9836: 9833: 9830: 9829: 9827: 9823: 9819: 9812: 9807: 9805: 9800: 9798: 9793: 9792: 9789: 9777: 9774: 9772: 9769: 9767: 9764: 9763: 9761: 9757: 9751: 9748: 9744: 9741: 9740: 9739: 9736: 9734: 9731: 9730: 9728: 9725: 9721: 9713: 9710: 9709: 9708: 9705: 9701: 9698: 9697: 9696: 9695:Hyperglycemia 9693: 9692: 9690: 9687: 9686:blood glucose 9682: 9674: 9670: 9669: 9668: 9667:Complications 9665: 9661: 9658: 9655: 9652: 9649: 9646: 9643: 9640: 9638: 9635: 9633: 9630: 9628: 9625: 9624: 9622: 9621: 9619: 9617: 9613: 9609: 9605: 9597: 9592: 9590: 9585: 9583: 9578: 9577: 9574: 9561: 9557: 9556: 9552: 9550: 9546: 9545: 9541: 9540: 9537: 9533: 9526: 9522: 9521: 9517: 9515: 9511: 9510: 9506: 9504: 9500: 9499: 9495: 9493: 9489: 9485: 9484: 9480: 9476: 9474: 9470: 9469: 9465: 9461: 9460: 9457: 9452: 9448: 9442: 9439: 9437: 9434: 9432: 9429: 9427: 9424: 9423: 9410: 9406: 9402: 9398: 9394: 9393:NIHR Evidence 9390: 9384: 9376: 9372: 9367: 9362: 9358: 9354: 9350: 9346: 9342: 9338: 9334: 9327: 9325: 9310: 9306: 9300: 9292: 9288: 9283: 9278: 9274: 9270: 9266: 9262: 9258: 9251: 9249: 9240: 9239: 9231: 9223: 9219: 9214: 9209: 9205: 9201: 9200:Diabetes Care 9197: 9190: 9182: 9178: 9173: 9168: 9164: 9160: 9155: 9150: 9146: 9142: 9138: 9131: 9123: 9119: 9114: 9109: 9105: 9101: 9096: 9091: 9087: 9083: 9079: 9072: 9064: 9060: 9055: 9050: 9046: 9042: 9037: 9032: 9028: 9024: 9020: 9013: 9005: 8998: 8983: 8977: 8970: 8969: 8961: 8953: 8949: 8944: 8939: 8936:(6): 861–77. 8935: 8931: 8930:Diabetes Care 8927: 8920: 8912: 8908: 8904: 8900: 8896: 8892: 8888: 8884: 8877: 8869: 8865: 8861: 8857: 8853: 8849: 8845: 8841: 8834: 8826: 8822: 8818: 8814: 8811:(6): 624–31. 8810: 8806: 8799: 8797: 8788: 8784: 8780: 8776: 8771: 8766: 8763:(2): 119–24. 8762: 8758: 8754: 8747: 8739: 8735: 8730: 8725: 8720: 8715: 8711: 8707: 8703: 8696: 8688: 8684: 8680: 8676: 8672: 8671:NIHR Evidence 8668: 8662: 8654: 8650: 8645: 8640: 8636: 8632: 8628: 8624: 8620: 8613: 8605: 8601: 8596: 8591: 8587: 8583: 8579: 8572: 8564: 8560: 8555: 8550: 8546: 8542: 8538: 8534: 8533:Diabetes Care 8530: 8523: 8515: 8511: 8507: 8503: 8499: 8494: 8489: 8485: 8481: 8480:Diabetes Care 8477: 8470: 8468: 8466: 8457: 8453: 8448: 8443: 8438: 8433: 8429: 8425: 8424:PLOS Medicine 8421: 8417: 8410: 8408: 8399: 8395: 8390: 8385: 8381: 8377: 8373: 8369: 8365: 8358: 8350: 8346: 8341: 8336: 8332: 8328: 8324: 8317: 8309: 8305: 8301: 8297: 8293: 8288: 8283: 8279: 8275: 8274:Diabetes Care 8271: 8264: 8256: 8252: 8247: 8242: 8238: 8234: 8230: 8226: 8222: 8215: 8207: 8203: 8198: 8193: 8189: 8185: 8181: 8177: 8173: 8166: 8158: 8154: 8149: 8144: 8140: 8136: 8132: 8125: 8117: 8113: 8108: 8103: 8100:(36): 1–248. 8099: 8095: 8091: 8084: 8076: 8072: 8067: 8062: 8058: 8054: 8050: 8046: 8042: 8035: 8027: 8023: 8019: 8015: 8007: 7999: 7995: 7990: 7985: 7981: 7977: 7973: 7969: 7962: 7955: 7947: 7943: 7938: 7933: 7929: 7925: 7921: 7917: 7913: 7906: 7898: 7894: 7889: 7884: 7880: 7876: 7872: 7868: 7864: 7860: 7856: 7849: 7841: 7837: 7832: 7827: 7823: 7819: 7815: 7811: 7807: 7803: 7799: 7792: 7784: 7780: 7776: 7772: 7768: 7763: 7758: 7754: 7750: 7749:Diabetes Care 7746: 7739: 7737: 7728: 7724: 7720: 7716: 7712: 7708: 7704: 7700: 7696: 7689: 7681: 7677: 7672: 7667: 7662: 7657: 7653: 7649: 7648:PLOS Medicine 7645: 7638: 7630: 7626: 7621: 7616: 7613:(3): 313–24. 7612: 7608: 7604: 7597: 7588: 7583: 7579: 7575: 7571: 7567: 7563: 7556: 7548: 7544: 7540: 7536: 7532: 7528: 7524: 7520: 7516: 7512: 7508: 7501: 7493: 7489: 7484: 7479: 7475: 7471: 7467: 7463: 7459: 7452: 7444: 7440: 7436: 7432: 7427: 7422: 7418: 7414: 7413:Diabetes Care 7410: 7403: 7395: 7391: 7386: 7381: 7377: 7373: 7369: 7362: 7354: 7350: 7345: 7340: 7336: 7332: 7328: 7324: 7323:Diabetes Care 7320: 7313: 7305: 7301: 7297: 7293: 7289: 7285: 7281: 7277: 7270: 7262: 7258: 7253: 7248: 7244: 7240: 7239:Diabetes Care 7236: 7229: 7221: 7217: 7212: 7207: 7203: 7199: 7195: 7188: 7180: 7176: 7171: 7166: 7162: 7158: 7154: 7150: 7146: 7139: 7131: 7127: 7123: 7119: 7115: 7110: 7105: 7101: 7097: 7096:Diabetes Care 7093: 7086: 7084: 7075: 7071: 7067: 7063: 7058: 7053: 7049: 7045: 7044:Diabetes Care 7041: 7034: 7018: 7017: 7012: 7006: 7004: 6987: 6983: 6977: 6970: 6966: 6962: 6958: 6954: 6950: 6946: 6942: 6938: 6934: 6930: 6926: 6919: 6911: 6907: 6903: 6899: 6895: 6891: 6884: 6876: 6872: 6868: 6864: 6859: 6854: 6850: 6846: 6842: 6838: 6834: 6827: 6819: 6815: 6810: 6805: 6801: 6797: 6793: 6789: 6785: 6778: 6770: 6766: 6761: 6756: 6751: 6746: 6742: 6738: 6734: 6730: 6726: 6719: 6711: 6707: 6702: 6697: 6693: 6689: 6685: 6681: 6677: 6670: 6662: 6658: 6653: 6648: 6644: 6640: 6636: 6632: 6631:Diabetes Care 6628: 6621: 6613: 6609: 6604: 6599: 6595: 6591: 6587: 6580: 6572: 6568: 6564: 6560: 6556: 6551: 6546: 6542: 6538: 6537:Diabetes Care 6534: 6527: 6519: 6515: 6511: 6507: 6503: 6499: 6496:(4): 288–93. 6495: 6491: 6484: 6476: 6472: 6467: 6462: 6458: 6454: 6450: 6446: 6442: 6435: 6427: 6423: 6418: 6413: 6409: 6405: 6401: 6394: 6386: 6382: 6377: 6372: 6368: 6364: 6360: 6353: 6345: 6341: 6335: 6327: 6323: 6319: 6315: 6311: 6307: 6303: 6299: 6291: 6283: 6279: 6274: 6269: 6265: 6261: 6257: 6253: 6249: 6242: 6234: 6230: 6225: 6220: 6216: 6212: 6208: 6204: 6200: 6193: 6185: 6181: 6176: 6171: 6167: 6163: 6159: 6155: 6151: 6144: 6142: 6140: 6131: 6127: 6122: 6117: 6113: 6109: 6105: 6101: 6097: 6090: 6088: 6086: 6077: 6073: 6069: 6065: 6060: 6055: 6051: 6047: 6043: 6036: 6028: 6024: 6019: 6014: 6009: 6004: 6000: 5996: 5993:(3): e93471. 5992: 5988: 5984: 5977: 5969: 5965: 5960: 5955: 5951: 5947: 5943: 5939: 5935: 5928: 5920: 5916: 5911: 5906: 5902: 5898: 5894: 5890: 5886: 5879: 5868: 5864: 5860: 5856: 5852: 5848: 5844: 5840: 5836: 5829: 5821: 5817: 5812: 5807: 5802: 5797: 5793: 5789: 5785: 5778: 5770: 5766: 5762: 5758: 5754: 5750: 5743: 5735: 5731: 5726: 5721: 5717: 5713: 5709: 5702: 5700: 5691: 5687: 5682: 5677: 5673: 5669: 5665: 5661: 5657: 5650: 5642: 5638: 5634: 5630: 5626: 5622: 5618: 5614: 5607: 5599: 5595: 5590: 5585: 5581: 5577: 5573: 5569: 5565: 5558: 5550: 5546: 5542: 5538: 5534: 5533:NIHR Evidence 5530: 5524: 5516: 5512: 5508: 5504: 5500: 5499:NIHR Evidence 5496: 5490: 5488: 5479: 5475: 5470: 5465: 5461: 5457: 5453: 5449: 5445: 5438: 5430: 5426: 5421: 5416: 5412: 5408: 5404: 5397: 5389: 5385: 5381: 5377: 5372: 5367: 5363: 5359: 5355: 5348: 5346: 5344: 5342: 5340: 5331: 5327: 5323: 5317: 5313: 5309: 5302: 5294: 5288: 5284: 5279: 5278: 5270: 5262: 5256: 5252: 5245: 5237: 5233: 5228: 5223: 5219: 5215: 5211: 5207: 5206:Diabetes Care 5203: 5196: 5188: 5184: 5180: 5176: 5172: 5167: 5162: 5158: 5154: 5153:Diabetes Care 5150: 5143: 5141: 5139: 5137: 5135: 5133: 5124: 5120: 5115: 5110: 5106: 5102: 5098: 5094: 5093:Diabetes Care 5090: 5083: 5075: 5071: 5066: 5061: 5057: 5053: 5049: 5045: 5044:Diabetes Care 5041: 5034: 5032: 5030: 5015:on 2007-05-29 5014: 5010: 5003: 4995: 4991: 4987: 4983: 4979: 4975: 4968: 4960: 4954: 4950: 4943: 4942: 4935: 4927: 4923: 4918: 4913: 4908: 4903: 4900:: 3567–3602. 4899: 4895: 4891: 4884: 4876: 4872: 4868: 4864: 4860: 4856: 4852: 4848: 4847: 4839: 4837: 4828: 4822: 4818: 4813: 4812: 4804: 4796: 4792: 4787: 4782: 4778: 4774: 4770: 4763: 4755: 4751: 4746: 4741: 4737: 4733: 4729: 4725: 4721: 4717: 4710: 4702: 4698: 4694: 4690: 4687:(1): E1–E15. 4686: 4682: 4674: 4666: 4662: 4658: 4654: 4650: 4646: 4642: 4638: 4631: 4623: 4619: 4614: 4609: 4605: 4601: 4597: 4590: 4582: 4578: 4574: 4570: 4566: 4562: 4558: 4554: 4547: 4539: 4535: 4530: 4525: 4521: 4517: 4513: 4509: 4508:Diabetes Care 4505: 4498: 4490: 4486: 4481: 4476: 4472: 4468: 4464: 4460: 4456: 4449: 4441: 4437: 4433: 4429: 4425: 4421: 4417: 4413: 4406: 4398: 4394: 4390: 4384: 4380: 4376: 4369: 4367: 4356: 4341: 4337: 4333: 4327: 4319: 4315: 4310: 4305: 4301: 4297: 4293: 4289: 4285: 4281: 4277: 4270: 4262: 4258: 4254: 4250: 4245: 4240: 4236: 4232: 4228: 4221: 4219: 4210: 4206: 4201: 4196: 4192: 4188: 4184: 4177: 4169: 4165: 4161: 4157: 4152: 4147: 4144:(6): 537–53. 4143: 4139: 4135: 4128: 4120: 4114: 4106: 4102: 4097: 4092: 4088: 4084: 4080: 4076: 4072: 4065: 4057: 4053: 4048: 4043: 4039: 4035: 4031: 4027: 4023: 4016: 4008: 4004: 3999: 3994: 3990: 3986: 3982: 3978: 3974: 3967: 3959: 3955: 3950: 3945: 3941: 3937: 3933: 3929: 3928:Diabetes Care 3925: 3918: 3910: 3906: 3901: 3896: 3892: 3888: 3884: 3880: 3876: 3869: 3861: 3857: 3853: 3849: 3844: 3839: 3836:(8): 549–58. 3835: 3831: 3827: 3820: 3818: 3809: 3805: 3800: 3795: 3791: 3787: 3783: 3779: 3775: 3768: 3760: 3756: 3752: 3748: 3745:(3): 309–19. 3744: 3740: 3732: 3724: 3720: 3716: 3712: 3708: 3704: 3700: 3696: 3692: 3688: 3684: 3677: 3669: 3665: 3660: 3655: 3652:(3): 437–45. 3651: 3647: 3643: 3636: 3628: 3624: 3619: 3614: 3610: 3606: 3602: 3598: 3594: 3587: 3579: 3575: 3570: 3565: 3561: 3557: 3553: 3549: 3545: 3541: 3537: 3530: 3522: 3518: 3513: 3508: 3504: 3500: 3496: 3492: 3488: 3484: 3477: 3475: 3466: 3462: 3458: 3454: 3450: 3446: 3442: 3438: 3431: 3416: 3412: 3408: 3402: 3388: 3384: 3378: 3370: 3366: 3362: 3358: 3354: 3350: 3343: 3335: 3331: 3327: 3323: 3316: 3314: 3312: 3310: 3308: 3306: 3304: 3302: 3300: 3298: 3283: 3279: 3273: 3265: 3261: 3257: 3253: 3246: 3238: 3234: 3230: 3226: 3222: 3218: 3214: 3210: 3203: 3201: 3199: 3197: 3195: 3193: 3191: 3189: 3187: 3185: 3176: 3172: 3168: 3164: 3160: 3156: 3152: 3148: 3141: 3133: 3129: 3125: 3119: 3115: 3111: 3104: 3102: 3100: 3098: 3096: 3094: 3092: 3090: 3088: 3079: 3075: 3071: 3065: 3061: 3057: 3050: 3048: 3039: 3035: 3030: 3025: 3021: 3017: 3013: 3009: 3008:Diabetes Care 3005: 2998: 2990: 2986: 2981: 2976: 2972: 2968: 2965:(2): 165–74. 2964: 2960: 2956: 2949: 2941: 2937: 2933: 2929: 2925: 2921: 2917: 2913: 2906: 2904: 2902: 2893: 2889: 2885: 2879: 2875: 2871: 2864: 2856: 2852: 2847: 2842: 2838: 2834: 2831:(2): 105–11. 2830: 2826: 2822: 2815: 2807: 2803: 2799: 2795: 2791: 2787: 2783: 2779: 2775: 2771: 2767: 2760: 2752: 2748: 2744: 2740: 2733: 2729: 2725: 2721: 2717: 2710: 2702: 2698: 2694: 2688: 2684: 2677: 2675: 2673: 2671: 2669: 2667: 2665: 2663: 2661: 2659: 2657: 2655: 2653: 2651: 2649: 2640: 2636: 2632: 2626: 2622: 2615: 2607: 2603: 2598: 2593: 2589: 2585: 2581: 2577: 2573: 2566: 2564: 2555: 2549: 2545: 2538: 2536: 2534: 2532: 2530: 2528: 2526: 2524: 2522: 2520: 2518: 2516: 2514: 2512: 2510: 2508: 2506: 2504: 2495: 2491: 2487: 2483: 2479: 2475: 2471: 2467: 2460: 2458: 2449: 2445: 2440: 2435: 2430: 2425: 2421: 2417: 2413: 2406: 2404: 2395: 2391: 2387: 2383: 2379: 2375: 2371: 2367: 2359: 2357: 2355: 2338: 2335:. June 2014. 2334: 2330: 2324: 2322: 2320: 2318: 2316: 2314: 2312: 2303: 2299: 2296:(2): 99–105. 2295: 2291: 2284: 2282: 2273: 2269: 2264: 2259: 2255: 2251: 2247: 2243: 2242:Diabetes Care 2239: 2232: 2230: 2213: 2209: 2205: 2199: 2197: 2195: 2193: 2191: 2182: 2178: 2172: 2157: 2153: 2149: 2143: 2141: 2139: 2137: 2135: 2133: 2131: 2129: 2127: 2125: 2123: 2118: 2110: 2101: 2099: 2094: 2092: 2088: 2084: 2080: 2076: 2072: 2068: 2064: 2059: 2057: 2053: 2049: 2045: 2041: 2037: 2024: 2014: 2012: 2008: 2003: 1997: 1994: 1990: 1986: 1982: 1977: 1975: 1971: 1967: 1959: 1954: 1949: 1939: 1937: 1932: 1928: 1919: 1916: 1911: 1909: 1905: 1902: 1898: 1893: 1891: 1887: 1877: 1874: 1870: 1866: 1862: 1858: 1857:ACE inhibitor 1854: 1850: 1846: 1841: 1832: 1830: 1826: 1822: 1818: 1813: 1809: 1807: 1806:Rosiglitazone 1803: 1799: 1795: 1791: 1787: 1786:sulfonylureas 1782: 1780: 1776: 1775:heart failure 1772: 1768: 1764: 1760: 1756: 1751: 1747: 1741: 1727: 1718: 1716: 1712: 1708: 1698: 1694: 1692: 1688: 1684: 1680: 1676: 1672: 1668: 1664: 1660: 1656: 1651: 1648: 1643: 1633: 1619: 1617: 1613: 1609: 1604: 1602: 1597: 1580: 1578: 1574: 1570: 1565: 1559: 1549: 1547: 1542: 1540: 1536: 1532: 1528: 1524: 1520: 1516: 1512: 1508: 1504: 1500: 1496: 1493: 1488: 1486: 1485:sulphonylurea 1481: 1477: 1473: 1470: 1466: 1461: 1459: 1458:dietary fiber 1452: 1442: 1441:populations. 1440: 1435: 1431: 1427: 1423: 1422:Black African 1419: 1414: 1407: 1405: 1401: 1397: 1393: 1389: 1385: 1382:, history of 1381: 1377: 1373: 1369: 1365: 1360: 1358: 1354: 1350: 1346: 1342: 1338: 1334: 1330: 1325: 1323: 1313: 1311: 1307: 1302: 1298: 1294: 1289: 1282: 1268: 1265: 1262: 1261: 1257: 1254: 1251: 1250: 1246: 1243: 1240: 1239: 1235: 1232: 1226: 1225: 1221: 1218: 1216: 1215: 1209: 1202: 1198: 1194: 1190: 1182: 1174: 1170: 1169: 1165: 1164: 1160: 1159: 1158: 1156: 1146: 1143: 1140: 1137: 1134: 1131: 1129: 1126: 1125: 1121: 1118: 1115: 1112: 1109: 1106: 1104: 1101: 1100: 1096: 1093: 1090: 1087: 1084: 1081: 1079: 1076: 1075: 1071: 1068: 1065: 1062: 1059: 1056: 1052: 1049: 1046: 1044: 1041: 1039: 1036: 1034: 1031: 1029: 1026: 1024: 1021: 1019: 1016: 1015: 999: 998: 994: 982: 978: 976: 971: 969: 965: 961: 957: 953: 949: 945: 941: 936: 933: 929: 925: 921: 917: 908: 902: 898: 891: 889: 885: 881: 877: 873: 869: 865: 861: 857: 853: 849: 845: 841: 837: 836:beta blockers 833: 829: 819: 817: 813: 811: 807: 803: 799: 795: 790: 788: 784: 781: 777: 773: 769: 763: 759: 749: 747: 743: 739: 735: 731: 727: 723: 719: 718:saturated fat 715: 710: 707: 706:Lack of sleep 703: 699: 695: 691: 687: 684:, poor diet, 683: 679: 675: 669: 659: 657: 656: 651: 650: 645: 641: 637: 633: 622: 620: 616: 612: 608: 604: 600: 596: 592: 588: 584: 577: 570:Complications 567: 565: 561: 557: 553: 552:loss of taste 549: 545: 541: 537: 533: 529: 525: 521: 512: 503: 501: 497: 493: 482: 477: 475: 471: 467: 463: 459: 455: 451: 446: 444: 443:saturated fat 440: 436: 432: 427: 425: 421: 417: 413: 409: 405: 401: 397: 393: 389: 384: 382: 378: 374: 369: 368:is uncommon. 367: 363: 359: 355: 351: 347: 343: 339: 338:heart disease 335: 331: 327: 323: 319: 315: 311: 307: 303: 299: 295: 291: 287: 283: 274: 270: 267: 263: 261: 257: 254: 250: 246: 243: 239: 235: 231: 227: 223: 221: 217: 214: 210: 207: 203: 199: 195: 191: 187: 184: 181:, lower-limb 180: 176: 172: 168: 167:heart disease 164: 160: 157: 155: 154:Complications 151: 148: 144: 140: 136: 133: 131: 127: 124: 123:Endocrinology 121: 119: 115: 106: 74: 73: 71: 69:Pronunciation 67: 62: 58: 53: 45: 41: 36: 30: 19: 10256:Hypoglycemia 10160:Ketoacidosis 10155:Hypoglycemia 10095:conventional 9997:Glucose test 9992:Fructosamine 9844: 9707:Hypoglycemia 9631: 9553: 9542: 9518: 9507: 9496: 9477: 9462: 9392: 9383: 9340: 9336: 9312:. Retrieved 9308: 9299: 9264: 9260: 9237: 9230: 9203: 9199: 9189: 9144: 9140: 9130: 9085: 9081: 9071: 9029:(4): e7614. 9026: 9022: 9012: 9003: 8997: 8985:. Retrieved 8967: 8960: 8933: 8929: 8919: 8886: 8882: 8876: 8846:(1): 24–33. 8843: 8839: 8833: 8808: 8804: 8760: 8756: 8746: 8709: 8705: 8695: 8670: 8661: 8626: 8622: 8612: 8585: 8581: 8571: 8536: 8532: 8522: 8483: 8479: 8427: 8423: 8371: 8367: 8357: 8330: 8326: 8316: 8277: 8273: 8263: 8228: 8224: 8214: 8179: 8175: 8165: 8138: 8135:Global Heart 8134: 8124: 8097: 8093: 8083: 8048: 8044: 8034: 8017: 8013: 8006: 7971: 7967: 7954: 7919: 7915: 7905: 7862: 7858: 7848: 7805: 7801: 7791: 7752: 7748: 7705:(1): 46–52. 7702: 7698: 7688: 7651: 7647: 7637: 7610: 7606: 7596: 7569: 7565: 7555: 7514: 7510: 7500: 7465: 7461: 7451: 7416: 7412: 7402: 7375: 7371: 7361: 7326: 7322: 7312: 7279: 7275: 7269: 7242: 7238: 7228: 7201: 7197: 7187: 7152: 7148: 7138: 7099: 7095: 7047: 7043: 7033: 7021:. Retrieved 7014: 6990:. Retrieved 6985: 6976: 6968: 6932: 6928: 6918: 6893: 6889: 6883: 6840: 6836: 6826: 6791: 6788:Diabetologia 6787: 6777: 6732: 6728: 6718: 6683: 6679: 6669: 6634: 6630: 6620: 6593: 6589: 6579: 6540: 6536: 6526: 6493: 6489: 6483: 6448: 6444: 6434: 6407: 6403: 6393: 6366: 6362: 6352: 6342:. May 2009. 6334: 6301: 6297: 6290: 6255: 6251: 6241: 6206: 6202: 6192: 6157: 6153: 6103: 6099: 6049: 6045: 6035: 5990: 5986: 5976: 5941: 5937: 5927: 5892: 5888: 5878: 5834: 5828: 5791: 5787: 5777: 5752: 5748: 5742: 5715: 5711: 5663: 5659: 5649: 5616: 5612: 5606: 5571: 5567: 5557: 5532: 5523: 5498: 5451: 5447: 5437: 5410: 5406: 5396: 5361: 5357: 5311: 5301: 5276: 5269: 5250: 5244: 5209: 5205: 5195: 5156: 5152: 5096: 5092: 5082: 5047: 5043: 5017:. 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Retrieved 2156:the original 2151: 2107: 2095: 2083:Charles Best 2060: 2052:Roman empire 2043: 2039: 2026: 1998: 1981:South Asians 1978: 1963: 1942:Epidemiology 1925: 1912: 1906: 1894: 1883: 1845:hypertension 1842: 1838: 1810: 1783: 1743: 1704: 1695: 1663:low-fat diet 1652: 1645: 1630: 1605: 1601:over-treated 1596:hypoglycemia 1581: 1569:hypertension 1561: 1543: 1489: 1462: 1454: 1415: 1408: 1404:pancreatitis 1380:hypertension 1361: 1326: 1319: 1290: 1274: 1222:Prediabetes 1178: 1152: 1047: 1042: 1037: 1032: 1027: 1022: 1017: 979: 972: 937: 913: 897: 872:glucagonomas 825: 814: 791: 765: 711: 694:Pima Indians 690:urbanization 671: 653: 647: 628: 619:hearing loss 579: 542:, recurrent 517: 478: 447: 428: 385: 370: 366:ketoacidosis 289: 285: 281: 280: 29: 10299:Diabetes UK 10027:SPINA-GBeta 9959:Blood tests 9865:Prediabetes 9637:gestational 9544:MedlinePlus 7204:(1): 1–13. 7023:29 November 6992:29 November 6680:Circulation 5872:(Retracted) 5851:10149/92337 4714:Hannon TS, 4643:(12): 138. 3879:Circulation 3481:Risérus U, 3387:Mayo Clinic 2343:10 February 2218:10 February 2098:weight loss 2091:NPH insulin 2085:discovered 2044:honey urine 2032: 1500 1895:The use of 1884:The use of 1871:(ARBs), or 1849:albuminuria 1847:and either 1825:NPH insulin 1748:available. 1721:Medications 1715:mindfulness 1612:gum disease 1509:, elevated 1505:, impaired 1439:Bangladeshi 1430:South Asian 1416:In the UK, 1396:prediabetes 1252:2h glucose 1195:(ADA), the 1048:DCCT % 789:functions. 640:nutritional 488: 1500 437:and low in 381:genetically 358:amputations 322:weight loss 251:, insulin, 189:Usual onset 183:amputations 143:weight loss 43:Other names 10350:Categories 10055:Prevention 10047:Management 9972:Biomarkers 9771:Insulinoma 9520:DiseasesDB 9314:2024-03-20 9263:(Review). 9088:(1): 658. 6750:2164/20480 5619:(6): 173. 5019:2007-05-29 4947:. Geneva: 4360:PMC6463748 4346:2008-08-04 3483:Willett WC 3421:2024-03-20 3392:2024-03-20 3287:2024-03-20 3256:StatPearls 3056:"Diabetes" 2790:1871/48558 2162:2012-01-09 2113:References 2075:overweight 1738:See also: 1669:such as a 1552:Management 1445:Prevention 1333:overweight 1320:Universal 1000:Condition 916:beta cells 852:acromegaly 816:Epigenetic 734:white rice 674:overweight 528:polyphagia 524:polydipsia 435:vegetables 408:beta cells 404:autoimmune 234:exercising 229:Prevention 224:Blood test 10100:pulsatile 10090:intensive 10002:C-peptide 9932:Permanent 9927:Transient 9892:Type 3a ( 9776:Insulitis 9726:disorders 9684:Abnormal 9555:eMedicine 9409:242997909 9357:2052-4897 9163:1948-9358 9104:1422-0067 9045:2168-8184 8868:207551737 8687:242149388 8502:1935-5548 8296:1935-5548 7879:2042-0188 7822:1539-3704 7771:1935-5548 7727:226280186 7531:1759-5029 7304:226250006 7198:Nutrition 7118:0149-5992 7074:228087486 6965:220651657 6949:1759-5037 6559:0149-5992 6451:: d4169. 6326:244580173 5895:: c4229. 5794:: i3857. 5549:247390548 5515:251299176 5380:0098-7484 5330:859778842 5175:0149-5992 4875:209341381 4853:: 76–82. 4397:261324723 3983:: e1454. 3560:1999-768X 3252:"Ageusia" 3237:207535925 3132:663097550 3078:725919496 2892:758391750 2806:205176936 2701:613429053 2639:965646175 2040:madhumeha 1970:developed 1908:Vitamin D 1873:aliskiren 1750:Metformin 1683:hazelnuts 1655:DASH diet 1622:Lifestyle 1546:vitamin D 1519:metformin 1476:metformin 1467:, a 2019 1322:screening 1316:Screening 1310:C-peptide 1072:< 6.0 985:Diagnosis 944:fat cells 832:thiazides 794:monogenic 787:beta cell 772:inherited 662:Lifestyle 536:itchiness 458:metformin 350:blindness 272:Frequency 260:Prognosis 249:metformin 241:Treatment 200:Long term 118:Specialty 10032:SPINA-GR 9922:Neonatal 9850:Type 4 ( 9841:cluster) 9818:Diabetes 9616:Diabetes 9604:pancreas 9375:32385076 9291:31520618 9222:15111519 9181:35432755 9122:36614099 9063:32399348 8987:18 March 8952:27222544 8903:22683132 8860:21293081 8825:19625245 8787:31797748 8779:19276974 8738:19726018 8653:32532814 8604:28957454 8563:20508233 8514:38078592 8456:26954482 8416:Davis BR 8398:28844155 8349:24687000 8308:38078574 8255:31575567 8225:BMJ Open 8206:26920333 8182:: i717. 8157:31451236 8116:20646668 8075:21735405 8026:23217404 7998:17636824 7946:29677303 7897:33489086 7840:36191315 7831:10155215 7783:38078590 7719:33159841 7680:22509138 7629:27434443 7547:34925223 7539:28664919 7492:25188210 7483:10680058 7443:58665219 7435:30617143 7394:33693499 7353:22778165 7296:33141798 7261:24357208 7220:25287761 7179:19160276 7130:38078584 7066:33298419 7016:UpToDate 6957:32690918 6910:19421969 6875:25505640 6867:16855995 6818:27747395 6769:35420698 6710:28069712 6661:23589542 6612:29507945 6571:38078586 6518:20819316 6510:21577100 6475:21791495 6426:22868819 6385:25668264 6344:Archived 6318:34893413 6282:25062463 6233:29114778 6184:30592787 6130:31794067 6076:58632705 6068:30638909 6027:24682091 5987:PLOS ONE 5968:28397016 5919:20724400 5867:23039006 5859:18646120 5820:27510511 5769:21855702 5734:24126648 5690:29205264 5641:26714233 5633:19043031 5598:33989535 5478:32470201 5429:25867111 5388:34427594 5236:22187472 5187:38078589 5123:20042775 5074:19502545 4994:20194231 4926:34413662 4867:31831356 4795:38169110 4754:28493515 4701:17341552 4657:29168047 4622:18832284 4581:22222112 4573:19444934 4538:20587728 4489:21499090 4440:21532595 4432:16255667 4340:Archived 4318:27398621 4261:43548816 4253:21198561 4209:26678054 4168:41018361 4160:22372998 4105:29589226 4056:22818936 4007:22422870 3958:20693348 3909:20308626 3860:45708828 3852:21807927 3808:26388413 3759:20493574 3715:27409811 3668:20071652 3627:24101783 3578:23071876 3521:19032965 3465:25569962 3457:23945844 3415:Archived 3369:21211730 3334:19145963 3264:31747182 3229:20194231 3175:28169759 3167:26621825 3038:23173134 2989:19466209 2932:16397575 2855:25859264 2798:22258959 2751:26421423 2732:16034881 2606:27733282 2494:29670619 2486:15669880 2448:26090370 2394:32016657 2386:27088241 2337:Archived 2302:18939392 2272:25342831 2104:Research 2063:Sushruta 2007:epidemic 1972:and the 1829:pregnant 1817:glargine 1627:Exercise 1515:acarbose 1492:Cochrane 1469:Cochrane 1306:antibody 1122:6.0–6.4 1116:< 126 1113:< 7.0 1097:6.0–6.4 1085:< 140 1082:< 7.8 1066:< 110 1063:< 6.1 1060:< 140 1057:< 7.8 1043:mmol/mol 952:glucagon 948:incretin 870:such as 804:(MODY), 752:Genetics 595:dementia 520:polyuria 450:exercise 412:pancreas 388:diabetes 213:genetics 197:Duration 130:Symptoms 9724:Insulin 9514:D003924 9366:7228474 9282:7054139 9172:8984567 9113:9820420 9054:7213678 8911:5198462 8644:7785164 8554:2875463 8447:4783064 8389:5600262 8246:6773352 8197:4770818 8066:6486036 7989:7389529 7937:5933330 7888:7809522 7671:3323508 7587:8701561 7344:3402256 7170:6486008 6858:8989410 6809:6207340 6760:9009294 6701:5502688 6652:3631867 6466:3144314 6273:4483466 6224:5820728 6175:6517235 6121:6889926 6018:3969361 5995:Bibcode 5959:5506108 5910:2924474 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Index

Diabetes mellitus type 2

/dəbtəs/
Specialty
Endocrinology
Symptoms
Increased thirst
frequent urination
weight loss
increased hunger
Complications
Hyperosmolar hyperglycemic state
diabetic ketoacidosis
heart disease
stroke
diabetic retinopathy
kidney failure
amputations
Obesity
genetics
Diagnostic method
exercising
Dietary changes
metformin
bariatric surgery
Prognosis
life expectancy
diabetes mellitus
high blood sugar
insulin resistance

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