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Dog Aging Project

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than in human studies. A further premise is that the longitudinal portion of the project seeks to understand the underlying biology of aging, as opposed to understanding individual age-related diseases. In this respect, if the aging process itself is addressed, then several age-related diseases could
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of 10,000 dogs over a 10-year period conducted across the United States. Individual dogs are followed for the duration of their lives to understand the biological and environmental factors that influence dog longevity. A small subset of those dogs (approximately 500) will be enrolled in a
170: 376: 161:. In 2017 the project reported the results of a 10 week trial showing that a small number of dogs that received rapamycin had better heart function than a 122:. The entire project also shares operational similarities to Darwin's Ark, a citizen science initiative of companion animals with more specific focus on 137:
that influence human life span. Since dogs age significantly more rapidly than humans, data on aging can be generated much more rapidly using a
406: 432: 291: 493: 483: 114:. The longitudinal study portion of the Dog Aging Project bears some similarity to the Golden Retriever Lifetime Study of the 78:
The project engages the general public to register their dogs in the studies, and therefore the project is an example of
82:. As of 2022 nearly 40,000 dogs have been registered with the project. The majority of the dogs will participate in a 225: 455: 126:. The initiatives are each managed to ensure the data can be integrated into a powerful master data set. 322: 197: 166: 157:
from the University of Washington. It has also received funding from small private donors, an example of
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for humans since they live in the same environment as humans. The project may thereby help identify
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of dogs. The project has implications for improving the life spans of humans and is an example of
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awarded the Dog Aging Project a five year grant to support further studies. Researchers from the
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Chemical structure of rapamycin, a pharmaceutical under evaluation for its effects on longevity
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are the co-directors of the project. Together with Chief Veterinarian, Dr.
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Texas A&M College of Veterinary Medicine & Biomedical Sciences
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The Dog Aging Project was founded in 2014 and received a US $ 200,000
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be delayed or avoided simultaneously. This is important because
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initiative. The investigators have committed to releasing all
24: 191: 292:"The Dog Aging Project Wants to Help Your Pet Live Longer" 43:, the project primarily focuses on research to understand 323:"Dogs Test Drugs Aimed at Humans' Biggest Killer: Age" 285: 283: 281: 475: 129:A premise of the project is that dogs may be a 278: 192:Healthy Aging and Longevity Research Institute 16:Study of aging in dogs with human implications 400: 398: 316: 314: 312: 237: 433:"It's a Dog's Life. That Could be Great" 404: 69: 395: 374: 289: 219: 217: 215: 213: 47:through the collection and analysis of 476: 447: 430: 424: 350:"Rapamycin: A real fountain of youth?" 320: 309: 347: 223: 173:are also investigators in the study. 368: 224:Ogden, Lesley Evans (27 July 2022). 210: 453: 405:Doughton, Sandi (2 November 2014). 23:is a long-term biological study of 13: 375:Golbeck, Jennifer (3 April 2015). 341: 290:Matchar, Emily (August 29, 2016). 230:Knowable Magazine | Annual Reviews 14: 520: 494:Senescence in non-human organisms 226:"Inside the brains of aging dogs" 179: 454:Kim, Allen (November 15, 2019). 356:. UBM Life Sciences, Veterinary 198:Golden Retriever Lifetime Study 194:of the University of Washington 484:Epidemiological study projects 253: 1: 431:Filler, Lane (May 18, 2016). 203: 321:Harmon, Amy (May 16, 2016). 102:The Dog Aging Project is an 7: 167:National Institute on Aging 10: 525: 118:although with much larger 354:veterinarynews.360dvm.com 239:10.1146/knowable-072622-1 186:Dog Aging Project website 27:in dogs, centered at the 116:Morris Animal Foundation 93:placebo-controlled study 59:to potentially increase 29:University of Washington 458:. Warner Media. cnn.com 95:of the pharmaceutical 75: 110:research data to the 73: 348:Vogelsang, Jessica. 296:Smithsonian Magazine 146:often have multiple 120:phenotypic diversity 165:. As of 2018, the 144:elderly individuals 327:The New York Times 84:longitudinal study 76: 411:The Seattle Times 383:. The Slate Group 265:Dog Aging Project 21:Dog Aging Project 516: 489:Ageing processes 468: 467: 465: 463: 451: 445: 444: 442: 440: 428: 422: 421: 419: 417: 402: 393: 392: 390: 388: 377:"Sick as a Dog?" 372: 366: 365: 363: 361: 345: 339: 338: 336: 334: 329:. New York Times 318: 307: 306: 304: 302: 287: 276: 275: 273: 271: 257: 251: 250: 248: 246: 241: 221: 131:sentinel species 33:Daniel Promislow 524: 523: 519: 518: 517: 515: 514: 513: 474: 473: 472: 471: 461: 459: 452: 448: 438: 436: 429: 425: 415: 413: 403: 396: 386: 384: 373: 369: 359: 357: 346: 342: 332: 330: 319: 310: 300: 298: 288: 279: 269: 267: 259: 258: 254: 244: 242: 222: 211: 206: 182: 176: 148:chronic disease 80:citizen science 57:pharmaceuticals 53:citizen science 37:Matt Kaeberlein 17: 12: 11: 5: 522: 512: 511: 506: 501: 496: 491: 486: 470: 469: 446: 423: 394: 367: 340: 308: 277: 252: 208: 207: 205: 202: 201: 200: 195: 188: 181: 180:External links 178: 15: 9: 6: 4: 3: 2: 521: 510: 507: 505: 502: 500: 497: 495: 492: 490: 487: 485: 482: 481: 479: 457: 450: 434: 427: 412: 408: 401: 399: 382: 378: 371: 355: 351: 344: 328: 324: 317: 315: 313: 297: 293: 286: 284: 282: 266: 262: 256: 240: 235: 231: 227: 220: 218: 216: 214: 209: 199: 196: 193: 189: 187: 184: 183: 177: 174: 172: 168: 164: 163:control group 160: 156: 151: 149: 145: 140: 136: 132: 127: 125: 121: 117: 113: 112:public domain 109: 105: 100: 98: 94: 90: 85: 81: 72: 68: 66: 62: 58: 54: 50: 46: 42: 38: 34: 31:. Professors 30: 26: 22: 509:Crowdfunding 460:. Retrieved 449: 437:. Retrieved 426: 414:. Retrieved 410: 385:. Retrieved 380: 370: 358:. Retrieved 353: 343: 331:. Retrieved 326: 299:. Retrieved 295: 268:. Retrieved 264: 255: 243:. Retrieved 229: 175: 159:crowdfunding 152: 150:conditions. 135:risk factors 128: 104:open science 101: 89:double-blind 77: 20: 18: 65:geroscience 41:Kate Creevy 478:Categories 462:6 February 261:"Our Team" 204:References 155:seed grant 108:anonymized 504:Longevity 435:. Newsday 416:10 August 381:slate.com 270:10 August 245:10 August 139:dog model 97:rapamycin 61:life span 45:dog aging 124:genetics 51:through 49:big data 439:9 June 387:9 June 360:9 June 333:8 June 301:8 June 25:aging 499:Dogs 464:2020 441:2017 418:2022 389:2017 362:2017 335:2017 303:2017 272:2022 247:2022 190:The 35:and 19:The 234:doi 67:. 480:: 409:. 397:^ 379:. 352:. 325:. 311:^ 294:. 280:^ 263:. 232:. 228:. 212:^ 91:, 466:. 443:. 420:. 391:. 364:. 337:. 305:. 274:. 249:. 236::

Index

aging
University of Washington
Daniel Promislow
Matt Kaeberlein
Kate Creevy
dog aging
big data
citizen science
pharmaceuticals
life span
geroscience

citizen science
longitudinal study
double-blind
placebo-controlled study
rapamycin
open science
anonymized
public domain
Morris Animal Foundation
phenotypic diversity
genetics
sentinel species
risk factors
dog model
elderly individuals
chronic disease
seed grant
crowdfunding

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