382:, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.
914:
463:
450:, another TH2 cytokine, primes eosinophilic exit from the bone marrow by lining vessel walls with adhesion molecules such as VCAM-1 and ICAM-1. When eosinophils are activated, they undergo cytolysis, where the breaking of the cell releases eosinophilic granules found in extracellular DNA traps. High concentrations of these DNA traps are known to cause cellular damage, as the granules they contain are responsible for the ligand-induced secretion of eosinophilic toxins which cause structural damage. There is evidence to suggest that eosinophil granule protein expression is regulated by the non-coding RNA
29:
808:
values are more informative than mean values for determining normal levels. Few large-scale studies have reported median blood eosinophil counts, with the median for healthy individuals being 100 cells/μL and the 95th percentile at 420 cells/μL. Thus, it is now evident that the normal median blood eosinophil count in healthy adults is around 100 cells/μL, with counts above 400 cells/μL considered outside the normal range. Current cutoffs such as 150 or 300 cells/μL used in asthma or COPD management fall within the normal range.
391:
41:
3710:
3722:
1014:, thereby inhibiting its function and reducing the number of developing eosinophils as well as the number of eosinophils leading to inflammation through antibody-dependent cell-mediated cytotoxicity and eosinophilic apoptosis. Lysosomotropic agents are an efficient means to target the lysosome-like eosinophil granules inducing eosinophil apoptosis.
413:
controls the development of eosinophils in the bone marrow, as they differentiate from myeloid precursor cells. Their lineage fate is determined by transcription factors, including GATA and C/EBP. Eosinophils produce and store many secondary granule proteins prior to their exit from the bone marrow.
924:
Eosinophils play an important role in asthma as the number of accumulated eosinophils corresponds to the severity of asthmatic reaction. Eosinophilia in mice models are shown to be associated with high interleukin-5 levels. Furthermore, mucosal bronchial biopsies conducted on patients with diseases
680:
Eosinophils are responsible for tissue damage and inflammation in many diseases, including asthma. High levels of interleukin-5 has been observed to up regulate the expression of adhesion molecules, which then facilitate the adhesion of eosinophils to endothelial cells, thereby causing inflammation
807:
Strong evidence indicates that blood eosinophil counts can predict the effectiveness of specific anti-inflammatory drugs. Despite their increasing use in clinical practice, data on "normal" blood eosinophil counts remain insufficient. Due to the right-skewed distribution of these counts, median
928:
Eosinophils can also cause tissue damage in the lungs of asthmatic patients. High concentrations of eosinophil major basic protein and eosinophil-derived neurotoxin that approach cytotoxic levels are observed at degranulation sites in the lungs as well as in the asthmatic sputum.
925:
such as asthma have been found to have higher levels of interleukin-5 leading to higher levels of eosinophils. The infiltration of eosinophils at these high concentrations causes an inflammatory reaction. This ultimately leads to airway remodelling and difficulty of breathing.
1533:
Metcalf D, Burgess AW, Johnson GR, Nicola NA, Nice EC, DeLamarter J, Thatcher DR, Mermod JJ (September 1986). "In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in
Escherichia coli: comparison with purified native GM-CSF".
2275:
Venge P, Byström J, Carlson M, Hâkansson L, Karawacjzyk M, Peterson C, Sevéus L, Trulson A (September 1999). "Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease".
1001:
target IL-13 and its receptor, which reduces eosinophilic inflammation in patients with asthma due to lowering the number of adhesion molecules present for eosinophils to bind to, thereby decreasing inflammation.
700:
Following activation by an immune stimulus, eosinophils degranulate to release an array of cytotoxic granule cationic proteins that are capable of inducing tissue damage and dysfunction. These include:
2179:
Morgan RK, Costello RW, Durcan N, Kingham PJ, Gleich GJ, McLean WG, Walsh MT (August 2005). "Diverse effects of eosinophil cationic granule proteins on IMR-32 nerve cell signaling and survival".
2376:
Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin A, Stahl N, Yancopoulos GD, Graham N, Pirozzi G (June 2013).
1920:
Horiuchi T, Weller PF (July 1997). "Expression of vascular endothelial growth factor by human eosinophils: upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5".
1805:
Saito K, Nagata M, Kikuchi I, Sakamoto Y (December 2004). "Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin".
779:
1506:
Metcalf D, Begley CG, Nicola NA, Johnson GR (March 1987). "Quantitative responsiveness of murine hemopoietic populations in vitro and in vivo to recombinant multi-CSF (IL-3)".
653:(worm) colonization and may be slightly elevated in the presence of certain parasites. Eosinophils are also involved in many other biological processes, including postpubertal
750:
remodelling. Eosinophil cationic protein creates toxic pores in the membranes of target cells, allowing potential entry of other cytotoxic molecules to the cell, can inhibit
435:
1881:
Kato Y, Fujisawa T, Nishimori H, Katsumata H, Atsuta J, Iguchi K, Kamiya H (2005). "Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils".
2417:
Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG (September 2011).
1727:
Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, Kay AB, Rothenberg ME (May 2008). "Eosinophils: biological properties and role in health and disease".
2690:
2658:
165:
730:
Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues. Eosinophil cationic protein and eosinophil-derived
3279:
1109:
2458:
Laviolette M, Gossage DL, Gauvreau G, Leigh R, Olivenstein R, Katial R, Busse WW, Wenzel S, Wu Y, Datta V, Kolbeck R, Molfino NA (November 2013).
1062:
response, the TH2 response becomes suppressed, showing that mice without TH2 cytokines are significantly less likely to express asthma symptoms.
2683:
3197:
2810:
2507:
Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P (September 2014).
1677:"The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications"
2591:"CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue"
1128:
975:
2558:
Vraila, Marianthi; Asp, Elin; Melo, Fabio Rabelo; Grujic, Mirjana; Rollman, Ola; Pejler, Gunnar; Lampinen, Maria (November 2023).
3272:
2676:
334:
in size with bilobed nuclei. While eosinophils are released into the bloodstream, they reside in tissue. They are found in the
2224:
Young JD, Peterson CG, Venge P, Cohn ZA (1986). "Mechanism of membrane damage mediated by human eosinophil cationic protein".
1441:
1294:
1158:
2590:
863:
1190:"Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma"
3265:
567:
263:-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to
898:. But, perhaps the most common cause for eosinophilia is an allergic condition such as asthma. In 1989, contaminated
2057:
1626:
Wagner LA, Christensen CJ, Dunn DM, Spangrude GJ, Georgelas A, Kelley L, Esplin MS, Weiss RB, Gleich GJ (June 2007).
2652:
3611:
2663:
917:
172:
1579:"Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors"
618:
There are also eosinophils that play a role in fighting viral infections, which is evident from the abundance of
3606:
414:
After maturation, eosinophils circulate in blood and migrate to inflammatory sites in tissues, or to sites of
3549:
2132:"Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins"
1099:
903:
822:
An increase in eosinophils, i.e., the presence of more than 500 eosinophils/microlitre of blood is called an
723:
160:
3080:
2888:
2083:"Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein"
843:
951:
711:
3700:
3435:
913:
835:
462:
153:
1770:
Lacy P (September 2005). "The role of Rho GTPases and SNAREs in mediator release from granulocytes".
747:
3257:
2193:
3142:
1409:
1392:
1089:
920:
of white blood cells, comparing eosinophil granulocyte amount (shown in light red) with other cells
887:
855:
148:
136:
248:
before migrating into blood, after which they are terminally differentiated and do not multiply.
3615:
3373:
3244:
3163:
3032:
2559:
775:
484:
1577:
Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K (January 1988).
330:
In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17
3637:
3355:
3291:
2188:
1240:
Rosenberg HF, Phipps S, Foster PS (June 2007). "Eosinophil trafficking in allergy and asthma".
1104:
1011:
288:
2460:"Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia"
1628:"EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression"
3747:
3742:
3584:
3440:
3418:
1975:
851:
717:
504:
296:
268:
937:
Treatments used to combat autoimmune diseases and conditions caused by eosinophils include:
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3601:
3534:
3445:
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3239:
2233:
1093:
875:
839:
670:
1136:
474:
Following activation, eosinophils effector functions include production of the following:
8:
3661:
3596:
3579:
3413:
3331:
3027:
3002:
980:
705:
316:
2353:
2320:
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3173:
2615:
2484:
2459:
2301:
2257:
2161:
2112:
2022:
1902:
1752:
1706:
1652:
1627:
1603:
1578:
1559:
1483:
1458:
1352:
1214:
1189:
907:
883:
831:
751:
2049:
2040:
Gleich GJ, Adolphson CR (1986). "The eosinophilic leukocyte: structure and function".
1818:
3529:
3295:
3037:
2620:
2540:
2489:
2440:
2399:
2358:
2340:
2293:
2289:
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2206:
2153:
2104:
2063:
2053:
2014:
1979:
1937:
1894:
1863:
1822:
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1783:
1744:
1740:
1698:
1693:
1676:
1657:
1608:
1551:
1515:
1488:
1437:
1414:
1344:
1290:
1267:
1219:
1083:
886:(in which eosinophils will be found in the squamous epithelium of the esophagus) and
771:
739:
689:
409:, which promotes the production of TH2 cytokines, including the interleukins (ILs).
335:
304:
2305:
2165:
2116:
2026:
1906:
1756:
1710:
470:, characterized by its bilobed nucleus despite scant visible eosinophilic cytoplasm.
3649:
3589:
3561:
3556:
3524:
3511:
3501:
3114:
3017:
2832:
2610:
2602:
2571:
2530:
2520:
2479:
2471:
2430:
2389:
2348:
2332:
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2241:
2198:
2143:
2094:
2045:
2006:
1971:
1929:
1886:
1853:
1814:
1779:
1736:
1688:
1647:
1639:
1598:
1590:
1543:
1478:
1470:
1404:
1356:
1336:
1257:
1249:
1209:
1201:
859:
783:
544:
500:
347:
339:
284:
201:
73:
1563:
3726:
3544:
3063:
2852:
2784:
2668:
2589:
Bolus WR, Gutierrez DA, Kennedy AJ, Anderson-Baucum EK, Hasty AH (October 2015).
1643:
941:
141:
28:
2628:
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3714:
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252:
50:
3736:
3539:
3428:
3209:
3119:
2764:
2606:
2344:
2202:
1997:
Shi HZ (September 2004). "Eosinophils function as antigen-presenting cells".
1933:
1474:
1205:
1086:, extreme increase (>1,500 cells per microliter) in eosinophil blood count
1059:
1055:
1051:
971:
963:
658:
654:
604:
600:
596:
592:
588:
584:
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540:
479:
410:
398:
320:
241:
205:
124:
2664:"What is an eosinophil?" at the Cincinnati Center for Eosinophilic Disorders
1858:
1841:
3506:
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3423:
3321:
3234:
3168:
3137:
2997:
2862:
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2700:
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2544:
2508:
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2403:
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2210:
2018:
1983:
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1826:
1791:
1748:
1702:
1661:
1547:
1492:
1348:
1271:
1223:
1077:
1046:
from a high fat diet. Mouse models of eosinophilia from mice infected with
1007:
998:
967:
899:
823:
817:
735:
685:
646:
627:
439:
300:
264:
256:
119:
2525:
2435:
2418:
2394:
2377:
2253:
2157:
2108:
2067:
1941:
1612:
1555:
1519:
1418:
1042:
expression. Furthermore, this effect was exaggerated when the mice became
2911:
2794:
2319:
Lommatzsch, Marek; Nair, Parameswaran; Virchow, Johann
Christian (2024).
1594:
1129:"eosinophil - Definition of eosinophil in English by Oxford Dictionaries"
1071:
1003:
955:
515:
488:
451:
367:
312:
245:
237:
40:
2010:
3629:
3382:
3288:
3022:
3012:
2992:
2984:
2929:
2919:
2857:
2749:
2560:"Monensin induces secretory granule-mediated cell death in eosinophils"
2535:
1035:
959:
895:
891:
871:
731:
635:
511:
492:
467:
419:
390:
331:
217:
46:
2336:
1890:
1842:"The cellular biology of eosinophil eicosanoid formation and function"
1675:
Trulson A, Byström J, Engström A, Larsson R, Venge P (February 2007).
1262:
826:, and is typically seen in people with a parasitic infestation of the
178:
3687:
3392:
3287:
3229:
3075:
3007:
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2924:
2789:
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2759:
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827:
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631:
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576:
379:
292:
225:
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213:
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1340:
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3450:
3408:
3362:
3326:
3202:
3096:
2975:
2963:
2939:
2934:
2722:
2509:"Mepolizumab treatment in patients with severe eosinophilic asthma"
1327:
Lambrecht BN, Hammad H (January 2015). "The immunology of asthma".
1080:, increase (>500 cells per microliter) in eosinophil blood count
1039:
1034:, there is an increased number of eosinophils, greater alternative
986:
791:
759:
743:
650:
563:
554:
496:
415:
363:
272:
209:
54:
3682:
3496:
3345:
3316:
3104:
2951:
1043:
1010:
are other treatment options that target the alpha subunit of the
639:
271:, it is this affinity that causes them to appear brick-red after
229:
2378:"Dupilumab in persistent asthma with elevated eosinophil levels"
2081:
Slifman NR, Loegering DA, McKean DJ, Gleich GJ (November 1986).
3654:
3642:
3387:
3338:
3192:
3068:
2732:
2130:
Zheutlin LM, Ackerman SJ, Gleich GJ, Thomas LL (October 1984).
882:
production (corticosteroids suppress blood eosinophil levels);
763:
755:
674:
643:
623:
431:
406:
359:
355:
343:
308:
233:
2457:
2416:
1880:
1625:
1054:
in mice spleen. Mouse models of asthma from OVA show a higher
79:
3147:
1674:
1031:
619:
436:
5-hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid
427:
423:
351:
324:
276:
2274:
2129:
2080:
2178:
1532:
1159:"What is an Eosinophil? | Definition & Function | CCED"
1027:
867:
571:
402:
375:
371:
260:
97:
82:
2181:
American
Journal of Respiratory Cell and Molecular Biology
2044:. Advances in Immunology. Vol. 39. pp. 177–253.
1922:
American
Journal of Respiratory Cell and Molecular Biology
1804:
1726:
1505:
902:
supplements caused a deadly form of eosinophilia known as
649:
and are associated with disease severity. They also fight
2375:
1459:"Eosinophil survival and apoptosis in health and disease"
1058:
response. When mice are administered IL-12 to induce the
989:(STI571) – inhibits PDGF-BB in hypereosinophilic leukemia
280:
103:
91:
45:
Eosinophil under the microscope (400×) from a peripheral
2506:
1839:
1576:
2223:
770:, and stimulate fibroblast cells to secrete mucus and
3698:
2716:
2318:
1431:
1284:
1239:
948:. Numbers of eosinophils in blood are rapidly reduced
100:
94:
88:
76:
742:
activity. Major basic protein induces mast cell and
106:
2557:
1840:Bandeira-Melo C, Bozza PT, Weller PF (March 2002).
1110:
List of distinct cell types in the adult human body
319:. These mediators are released by a process called
208:components responsible for combating multicellular
85:
2698:
1962:Rothenberg ME, Hogan SP (2006). "The eosinophil".
295:, which contain many chemical mediators, such as
3734:
1883:International Archives of Allergy and Immunology
323:following activation of the eosinophil, and are
2039:
1961:
1326:
688:is considered a major diagnostic criterion for
478:Cationic granule proteins and their release by
228:, they also control mechanisms associated with
2464:The Journal of Allergy and Clinical Immunology
2419:"Lebrikizumab treatment in adults with asthma"
1919:
1846:The Journal of Allergy and Clinical Immunology
1432:Young B, Lowe JS, Stevens A, Heath JW (2006).
1410:10.1182/blood.V79.12.3101.bloodjournal79123101
1285:Young B, Lowe jo, Stevens A, Heath JW (2006).
1242:The Journal of Allergy and Clinical Immunology
3273:
2684:
1957:
1955:
1953:
1951:
1619:
1386:
1038:activation, and a propensity towards type 2
405:cells both express the transcription factor
1456:
1384:
1382:
1380:
1378:
1376:
1374:
1372:
1370:
1368:
1366:
1322:
1320:
1318:
1316:
1314:
1312:
1310:
1308:
1306:
1187:
622:they contain within their granules, and in
3280:
3266:
2691:
2677:
2655:- BioWeb at University of Wisconsin System
2564:Journal of Allergy and Clinical Immunology
2321:"Normal Blood Eosinophil Counts in Humans"
1948:
1807:Annals of Allergy, Asthma & Immunology
1092:, presence of a premalignant or malignant
39:
27:
2614:
2534:
2524:
2483:
2434:
2393:
2352:
2192:
2147:
2098:
1857:
1692:
1651:
1602:
1482:
1463:Allergy, Asthma & Immunology Research
1408:
1393:"Interleukin-5, Eosinophils, and Disease"
1390:
1261:
1213:
1194:Allergy, Asthma & Immunology Research
1976:10.1146/annurev.immunol.24.021605.090720
1722:
1720:
1363:
1303:
1235:
1233:
912:
797:
461:
389:
287:. The staining is concentrated in small
3198:Megakaryocyte–erythroid progenitor cell
1188:Uhm TG, Kim BS, Chung IY (March 2012).
1096:of eosinophils in bone marrow and blood
974:, which eliminates eosinophils through
3735:
684:An accumulation of eosinophils in the
503:, which is preferentially produced by
3261:
2672:
1717:
1230:
1183:
1181:
1179:
983:of leukotriene synthesis or receptors
786:in the target, causing cell death by
2312:
1769:
1763:
1583:The Journal of Experimental Medicine
1074:, decrease in eosinophil blood count
864:lymphocyte-variant hypereosinophilia
746:degranulation, and is implicated in
669:. They have also been implicated in
2513:The New England Journal of Medicine
2423:The New England Journal of Medicine
2382:The New England Journal of Medicine
1996:
695:
327:to both parasite and host tissues.
13:
1457:Park YM, Bochner BS (April 2010).
1436:(5th ed.). Elsevier Limited.
1289:(5th ed.). Elsevier Limited.
1176:
966:, prevents eosinophilopoiesis, or
466:Histology of an eosinophil within
14:
3764:
2646:
2278:Clinical and Experimental Allergy
1729:Clinical and Experimental Allergy
1681:Clinical and Experimental Allergy
1017:
3720:
3708:
2290:10.1046/j.1365-2222.1999.00542.x
2042:Advances in Immunology Volume 39
1784:10.1016/j.pharmthera.2005.03.008
1741:10.1111/j.1365-2222.2008.02958.x
1694:10.1111/j.1365-2222.2007.02644.x
918:Reference ranges for blood tests
173:Anatomical terms of microanatomy
72:
2582:
2551:
2500:
2451:
2410:
2369:
2268:
2217:
2172:
2123:
2074:
2033:
1990:
1913:
1885:. 137. 137 Suppl 1 (1): 17–20.
1874:
1833:
1798:
1772:Pharmacology & Therapeutics
1668:
1570:
1526:
1499:
906:, which was reminiscent of the
811:
780:reactive nitrogen intermediates
774:. Eosinophil peroxidase forms
3607:Immunoglobulin class switching
1536:Journal of Cellular Physiology
1450:
1434:Wheater's Functional Histology
1425:
1287:Wheater's Functional Histology
1278:
1151:
1121:
993:Monoclonal antibodies such as
890:; and with the use of certain
870:diseases (such as exfoliative
802:
385:
1:
2050:10.1016/S0065-2776(08)60351-X
1819:10.1016/S1081-1206(10)61269-0
1133:Oxford Dictionaries - English
1115:
1100:Chronic eosinophilic leukemia
904:eosinophilia-myalgia syndrome
724:eosinophil-derived neurotoxin
638:, are important mediators of
338:and the junction between the
53:surround the eosinophil, two
2889:Extramedullary hematopoiesis
2595:Journal of Leukocyte Biology
1999:Journal of Leukocyte Biology
1644:10.1182/blood-2006-06-027987
932:
844:Systemic lupus erythematosus
16:Variety of white blood cells
7:
2149:10.4049/jimmunol.133.4.2180
2100:10.4049/jimmunol.137.9.2913
1964:Annual Review of Immunology
1248:(6): 1303–10, quiz 1311–2.
1163:www.cincinnatichildrens.org
1065:
1050:showed an increase in IL-5
952:monoclonal antibody therapy
712:eosinophil cationic protein
457:
10:
3769:
3436:Polyclonal B cell response
2576:10.1016/j.jaci.2023.07.012
2476:10.1016/j.jaci.2013.05.020
1254:10.1016/j.jaci.2007.03.048
815:
766:, induce degranulation by
630:. Eosinophils, along with
33:3D rendering of eosinophil
3670:
3628:
3570:
3471:
3401:
3309:
3302:
3222:
3182:
3156:
3128:
3095:
3055:Antigen-presenting cells
3048:
2983:
2974:
2910:
2901:
2881:
2843:
2818:
2809:
2780:
2740:
2731:
2707:
1391:Sanderson, Colin (1992).
836:collagen vascular disease
510:Lipid mediators like the
418:infection in response to
171:
159:
147:
135:
130:
118:
67:
62:
38:
26:
21:
3143:Nucleated red blood cell
2699:Myeloid blood cells and
2607:10.1189/jlb.3HI0115-018R
2203:10.1165/rcmb.2005-0056OC
1934:10.1165/ajrcmb.17.1.2796
1475:10.4168/aair.2010.2.2.87
1206:10.4168/aair.2012.4.2.68
1090:Clonal hypereosinophilia
888:eosinophilic esophagitis
878:and other causes of low
856:clonal hypereosinophilia
3245:Hematopoietic stem cell
3164:Leukocyte extravasation
3033:Foreign-body giant cell
1859:10.1067/mai.2002.121529
1508:Experimental Hematology
776:reactive oxygen species
485:Reactive oxygen species
57:at the top left corner.
3550:Tolerance in pregnancy
3292:adaptive immune system
1548:10.1002/jcp.1041280311
1105:Acidophile (histology)
921:
471:
395:
3585:Somatic hypermutation
3419:Polyclonal antibodies
3414:Monoclonal antibodies
2659:Histology at ucsf.edu
2526:10.1056/nejmoa1403290
2436:10.1056/nejmoa1106469
2395:10.1056/nejmoa1304048
2136:Journal of Immunology
2087:Journal of Immunology
916:
852:eosinophilic leukemia
798:Clinical significance
718:eosinophil peroxidase
505:eosinophil peroxidase
465:
393:
297:eosinophil peroxidase
3602:Junctional diversity
3370:Antigen presentation
3240:Hematopoietic system
3028:Langhans giant cells
1595:10.1084/jem.167.1.43
840:rheumatoid arthritis
671:antigen presentation
346:, and, in the lower
291:within the cellular
240:that develop during
3597:V(D)J recombination
3580:Affinity maturation
3332:Antigenic variation
3003:Alveolar macrophage
2570:(5): 1312–1320.e3.
2470:(5): 1086–1096.e5.
2238:1986Natur.321..613Y
2011:10.1189/jlb.0404228
706:major basic protein
692:(nasal allergies).
681:and tissue damage.
446:(LTB4) and MCP1/4.
430:(eotaxin-2), CCL5 (
342:and medulla of the
317:major basic protein
200:, are a variety of
196:or, less commonly,
192:, sometimes called
3174:Intrinsic immunity
3038:Touton giant cells
1139:on 8 February 2018
922:
910:in Spain in 1981.
908:toxic oil syndrome
884:reflux esophagitis
772:glycosaminoglycans
640:allergic responses
472:
396:
394:Blood cell lineage
305:deoxyribonucleases
154:H2.00.04.1.02017
3696:
3695:
3624:
3623:
3374:professional APCs
3255:
3254:
3218:
3217:
3091:
3090:
3018:Epithelioid cells
2897:
2896:
2877:
2876:
2873:
2872:
2805:
2804:
2337:10.1159/000537833
1891:10.1159/000085427
1443:978-0-443-06850-8
1403:(12): 3101–3109.
1329:Nature Immunology
1296:978-0-443-06850-8
1084:Hypereosinophilia
876:Addison's disease
850:diseases such as
690:allergic rhinitis
553:Enzymes, such as
370:, but not in the
285:Romanowsky method
202:white blood cells
187:
186:
182:
3760:
3725:
3724:
3723:
3713:
3712:
3704:
3590:Clonal selection
3562:Immune privilege
3557:Immunodeficiency
3512:Cross-reactivity
3502:Hypersensitivity
3307:
3306:
3282:
3275:
3268:
3259:
3258:
3189:Precursor cells
3115:Promegakaryocyte
2981:
2980:
2908:
2907:
2833:Promegakaryocyte
2816:
2815:
2738:
2737:
2729:
2728:
2714:
2713:
2693:
2686:
2679:
2670:
2669:
2641:
2640:
2638:
2636:
2627:. Archived from
2618:
2586:
2580:
2579:
2555:
2549:
2548:
2538:
2528:
2519:(13): 1198–207.
2504:
2498:
2497:
2487:
2455:
2449:
2448:
2438:
2414:
2408:
2407:
2397:
2373:
2367:
2366:
2356:
2316:
2310:
2309:
2272:
2266:
2265:
2246:10.1038/321613a0
2221:
2215:
2214:
2196:
2176:
2170:
2169:
2151:
2127:
2121:
2120:
2102:
2078:
2072:
2071:
2037:
2031:
2030:
1994:
1988:
1987:
1959:
1946:
1945:
1917:
1911:
1910:
1878:
1872:
1871:
1861:
1837:
1831:
1830:
1802:
1796:
1795:
1767:
1761:
1760:
1724:
1715:
1714:
1696:
1672:
1666:
1665:
1655:
1623:
1617:
1616:
1606:
1574:
1568:
1567:
1530:
1524:
1523:
1503:
1497:
1496:
1486:
1454:
1448:
1447:
1429:
1423:
1422:
1412:
1388:
1361:
1360:
1324:
1301:
1300:
1282:
1276:
1275:
1265:
1237:
1228:
1227:
1217:
1185:
1174:
1173:
1171:
1169:
1155:
1149:
1148:
1146:
1144:
1135:. Archived from
1125:
1022:Within the fat (
860:Hodgkin lymphoma
784:oxidative stress
748:peripheral nerve
696:Granule proteins
501:hypobromous acid
348:gastrointestinal
179:edit on Wikidata
176:
113:
112:
109:
108:
105:
102:
99:
96:
93:
90:
87:
84:
81:
78:
43:
31:
19:
18:
3768:
3767:
3763:
3762:
3761:
3759:
3758:
3757:
3733:
3732:
3731:
3721:
3719:
3707:
3699:
3697:
3692:
3666:
3620:
3566:
3545:Clonal deletion
3473:
3467:
3397:
3298:
3286:
3256:
3251:
3214:
3178:
3157:Immune response
3152:
3130:Red blood cells
3124:
3087:
3064:Langerhans cell
3059:Dendritic cells
3044:
2970:
2893:
2869:
2853:Proerythroblast
2839:
2801:
2785:Monocytopoiesis
2776:
2720:
2703:
2697:
2649:
2644:
2634:
2632:
2587:
2583:
2556:
2552:
2505:
2501:
2456:
2452:
2429:(12): 1088–98.
2415:
2411:
2388:(26): 2455–66.
2374:
2370:
2317:
2313:
2273:
2269:
2232:(6070): 613–6.
2222:
2218:
2194:10.1.1.335.4162
2177:
2173:
2128:
2124:
2079:
2075:
2060:
2038:
2034:
1995:
1991:
1960:
1949:
1918:
1914:
1879:
1875:
1838:
1834:
1803:
1799:
1768:
1764:
1725:
1718:
1673:
1669:
1624:
1620:
1575:
1571:
1531:
1527:
1504:
1500:
1455:
1451:
1444:
1430:
1426:
1389:
1364:
1341:10.1038/ni.3049
1325:
1304:
1297:
1283:
1279:
1238:
1231:
1186:
1177:
1167:
1165:
1157:
1156:
1152:
1142:
1140:
1127:
1126:
1122:
1118:
1068:
1020:
942:corticosteroids
935:
820:
814:
805:
800:
698:
659:oestrus cycling
626:removal during
548:
537:
530:
523:
460:
388:
204:and one of the
183:
75:
71:
58:
51:Red blood cells
34:
17:
12:
11:
5:
3766:
3756:
3755:
3750:
3745:
3730:
3729:
3717:
3694:
3693:
3691:
3690:
3685:
3680:
3674:
3672:
3668:
3667:
3665:
3664:
3659:
3658:
3657:
3647:
3646:
3645:
3634:
3632:
3626:
3625:
3622:
3621:
3619:
3618:
3609:
3604:
3599:
3594:
3593:
3592:
3587:
3576:
3574:
3572:Immunogenetics
3568:
3567:
3565:
3564:
3559:
3554:
3553:
3552:
3547:
3542:
3537:
3532:
3520:
3519:
3517:Co-stimulation
3514:
3509:
3504:
3499:
3494:
3489:
3484:
3477:
3475:
3469:
3468:
3466:
3465:
3460:
3458:Immune complex
3454:
3453:
3448:
3443:
3438:
3433:
3432:
3431:
3426:
3421:
3416:
3405:
3403:
3399:
3398:
3396:
3395:
3390:
3385:
3380:
3378:Dendritic cell
3366:
3365:
3360:
3359:
3358:
3356:Conformational
3353:
3342:
3341:
3336:
3335:
3334:
3329:
3324:
3313:
3311:
3304:
3300:
3299:
3285:
3284:
3277:
3270:
3262:
3253:
3252:
3250:
3249:
3248:
3247:
3237:
3232:
3226:
3224:
3220:
3219:
3216:
3215:
3213:
3212:
3207:
3206:
3205:
3200:
3195:
3186:
3184:
3180:
3179:
3177:
3176:
3171:
3166:
3160:
3158:
3154:
3153:
3151:
3150:
3145:
3140:
3134:
3132:
3126:
3125:
3123:
3122:
3117:
3112:
3110:Megakaryoblast
3107:
3101:
3099:
3093:
3092:
3089:
3088:
3086:
3085:
3084:
3083:
3073:
3072:
3071:
3066:
3061:
3052:
3050:
3046:
3045:
3043:
3042:
3041:
3040:
3035:
3030:
3020:
3015:
3010:
3005:
3000:
2995:
2989:
2987:
2978:
2972:
2971:
2969:
2968:
2967:
2966:
2956:
2955:
2954:
2944:
2943:
2942:
2932:
2927:
2922:
2916:
2914:
2905:
2903:Myeloid tissue
2899:
2898:
2895:
2894:
2892:
2891:
2885:
2883:
2879:
2878:
2875:
2874:
2871:
2870:
2868:
2867:
2866:
2865:
2860:
2855:
2848:Erythropoiesis
2844:
2841:
2840:
2838:
2837:
2836:
2835:
2830:
2828:Megakaryoblast
2823:Thrombopoiesis
2819:
2813:
2807:
2806:
2803:
2802:
2800:
2799:
2798:
2797:
2792:
2781:
2778:
2777:
2775:
2774:
2773:
2772:
2767:
2762:
2757:
2752:
2745:Granulopoiesis
2741:
2735:
2726:
2711:
2705:
2704:
2696:
2695:
2688:
2681:
2673:
2667:
2666:
2661:
2656:
2648:
2647:External links
2645:
2643:
2642:
2581:
2550:
2499:
2450:
2409:
2368:
2331:(4): 214–216.
2311:
2284:(9): 1172–86.
2267:
2216:
2171:
2122:
2073:
2058:
2032:
1989:
1947:
1912:
1873:
1852:(3): 393–400.
1832:
1813:(6): 594–600.
1797:
1762:
1716:
1667:
1638:(12): 5191–8.
1618:
1569:
1525:
1498:
1449:
1442:
1424:
1362:
1302:
1295:
1277:
1229:
1175:
1150:
1119:
1117:
1114:
1113:
1112:
1107:
1102:
1097:
1087:
1081:
1075:
1067:
1064:
1019:
1018:Animal studies
1016:
991:
990:
984:
978:
949:
934:
931:
880:corticosteroid
816:Main article:
813:
810:
804:
801:
799:
796:
762:production by
728:
727:
721:
715:
709:
697:
694:
665:rejection and
616:
615:
574:
560:Growth factors
557:
551:
546:
535:
528:
521:
508:
482:
459:
456:
448:Interleukin-13
444:leukotriene B4
438:, and certain
387:
384:
185:
184:
175:
169:
168:
163:
157:
156:
151:
145:
144:
139:
133:
132:
128:
127:
122:
116:
115:
69:
65:
64:
60:
59:
44:
36:
35:
32:
24:
23:
15:
9:
6:
4:
3:
2:
3765:
3754:
3751:
3749:
3746:
3744:
3741:
3740:
3738:
3728:
3718:
3716:
3711:
3706:
3705:
3702:
3689:
3686:
3684:
3681:
3679:
3676:
3675:
3673:
3669:
3663:
3660:
3656:
3653:
3652:
3651:
3648:
3644:
3641:
3640:
3639:
3636:
3635:
3633:
3631:
3627:
3617:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3591:
3588:
3586:
3583:
3582:
3581:
3578:
3577:
3575:
3573:
3569:
3563:
3560:
3558:
3555:
3551:
3548:
3546:
3543:
3541:
3540:Clonal anergy
3538:
3536:
3533:
3531:
3528:
3527:
3526:
3522:
3521:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3479:
3478:
3476:
3470:
3464:
3461:
3459:
3456:
3455:
3452:
3449:
3447:
3444:
3442:
3439:
3437:
3434:
3430:
3429:Microantibody
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3411:
3410:
3407:
3406:
3404:
3400:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3375:
3371:
3368:
3367:
3364:
3361:
3357:
3354:
3352:
3349:
3348:
3347:
3344:
3343:
3340:
3337:
3333:
3330:
3328:
3325:
3323:
3320:
3319:
3318:
3315:
3314:
3312:
3308:
3305:
3301:
3297:
3293:
3290:
3283:
3278:
3276:
3271:
3269:
3264:
3263:
3260:
3246:
3243:
3242:
3241:
3238:
3236:
3233:
3231:
3228:
3227:
3225:
3221:
3211:
3210:Myelomonocyte
3208:
3204:
3201:
3199:
3196:
3194:
3191:
3190:
3188:
3187:
3185:
3181:
3175:
3172:
3170:
3167:
3165:
3162:
3161:
3159:
3155:
3149:
3146:
3144:
3141:
3139:
3136:
3135:
3133:
3131:
3127:
3121:
3120:Megakaryocyte
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3102:
3100:
3098:
3094:
3082:
3079:
3078:
3077:
3074:
3070:
3067:
3065:
3062:
3060:
3057:
3056:
3054:
3053:
3051:
3047:
3039:
3036:
3034:
3031:
3029:
3026:
3025:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2998:Kupffer cells
2996:
2994:
2991:
2990:
2988:
2986:
2982:
2979:
2977:
2973:
2965:
2962:
2961:
2960:
2957:
2953:
2950:
2949:
2948:
2945:
2941:
2938:
2937:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2917:
2915:
2913:
2909:
2906:
2904:
2900:
2890:
2887:
2886:
2884:
2880:
2864:
2861:
2859:
2856:
2854:
2851:
2850:
2849:
2846:
2845:
2842:
2834:
2831:
2829:
2826:
2825:
2824:
2821:
2820:
2817:
2814:
2812:
2808:
2796:
2793:
2791:
2788:
2787:
2786:
2783:
2782:
2779:
2771:
2768:
2766:
2765:Metamyelocyte
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2747:
2746:
2743:
2742:
2739:
2736:
2734:
2730:
2727:
2724:
2719:
2715:
2712:
2710:
2709:Hematopoiesis
2706:
2702:
2694:
2689:
2687:
2682:
2680:
2675:
2674:
2671:
2665:
2662:
2660:
2657:
2654:
2651:
2650:
2631:on 9 May 2017
2630:
2626:
2622:
2617:
2612:
2608:
2604:
2601:(4): 467–77.
2600:
2596:
2592:
2585:
2577:
2573:
2569:
2565:
2561:
2554:
2546:
2542:
2537:
2532:
2527:
2522:
2518:
2514:
2510:
2503:
2495:
2491:
2486:
2481:
2477:
2473:
2469:
2465:
2461:
2454:
2446:
2442:
2437:
2432:
2428:
2424:
2420:
2413:
2405:
2401:
2396:
2391:
2387:
2383:
2379:
2372:
2364:
2360:
2355:
2350:
2346:
2342:
2338:
2334:
2330:
2326:
2322:
2315:
2307:
2303:
2299:
2295:
2291:
2287:
2283:
2279:
2271:
2263:
2259:
2255:
2251:
2247:
2243:
2239:
2235:
2231:
2227:
2220:
2212:
2208:
2204:
2200:
2195:
2190:
2187:(2): 169–77.
2186:
2182:
2175:
2167:
2163:
2159:
2155:
2150:
2145:
2142:(4): 2180–5.
2141:
2137:
2133:
2126:
2118:
2114:
2110:
2106:
2101:
2096:
2093:(9): 2913–7.
2092:
2088:
2084:
2077:
2069:
2065:
2061:
2059:9780120224395
2055:
2051:
2047:
2043:
2036:
2028:
2024:
2020:
2016:
2012:
2008:
2004:
2000:
1993:
1985:
1981:
1977:
1973:
1970:(1): 147–74.
1969:
1965:
1958:
1956:
1954:
1952:
1943:
1939:
1935:
1931:
1927:
1923:
1916:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1877:
1869:
1865:
1860:
1855:
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1828:
1824:
1820:
1816:
1812:
1808:
1801:
1793:
1789:
1785:
1781:
1778:(3): 358–76.
1777:
1773:
1766:
1758:
1754:
1750:
1746:
1742:
1738:
1735:(5): 709–50.
1734:
1730:
1723:
1721:
1712:
1708:
1704:
1700:
1695:
1690:
1687:(2): 208–18.
1686:
1682:
1678:
1671:
1663:
1659:
1654:
1649:
1645:
1641:
1637:
1633:
1629:
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1610:
1605:
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1596:
1592:
1588:
1584:
1580:
1573:
1565:
1561:
1557:
1553:
1549:
1545:
1542:(3): 421–31.
1541:
1537:
1529:
1521:
1517:
1514:(3): 288–95.
1513:
1509:
1502:
1494:
1490:
1485:
1480:
1476:
1472:
1469:(2): 87–101.
1468:
1464:
1460:
1453:
1445:
1439:
1435:
1428:
1420:
1416:
1411:
1406:
1402:
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1199:
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1057:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1015:
1013:
1012:IL-5 receptor
1009:
1005:
1000:
996:
988:
985:
982:
979:
977:
973:
972:IL-5 receptor
969:
965:
961:
957:
953:
950:
947:
943:
940:
939:
938:
930:
926:
919:
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849:
845:
841:
837:
833:
829:
825:
819:
809:
795:
793:
789:
785:
782:that promote
781:
777:
773:
769:
765:
761:
757:
753:
752:proliferation
749:
745:
741:
737:
736:ribonucleases
733:
725:
722:
719:
716:
713:
710:
707:
704:
703:
702:
693:
691:
687:
682:
678:
676:
672:
668:
664:
660:
657:development,
656:
655:mammary gland
652:
648:
645:
641:
637:
633:
629:
625:
621:
614:
610:
606:
602:
598:
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582:
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573:
569:
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561:
558:
556:
552:
549:
542:
541:prostaglandin
538:
531:
524:
517:
513:
509:
506:
502:
498:
494:
490:
486:
483:
481:
480:degranulation
477:
476:
475:
469:
464:
455:
453:
449:
445:
441:
437:
433:
429:
426:(eotaxin-1),
425:
421:
417:
412:
408:
404:
400:
392:
383:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
328:
326:
322:
321:degranulation
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
265:coal tar dyes
262:
258:
254:
249:
247:
243:
242:hematopoiesis
239:
235:
231:
227:
223:
220:. Along with
219:
215:
211:
207:
206:immune system
203:
199:
195:
191:
180:
174:
170:
167:
164:
162:
158:
155:
152:
150:
146:
143:
140:
138:
134:
129:
126:
125:Immune system
123:
121:
117:
111:
70:
68:Pronunciation
66:
61:
56:
52:
48:
42:
37:
30:
25:
20:
3748:Granulocytes
3743:Cell biology
3507:Inflammation
3492:Alloimmunity
3487:Autoimmunity
3472:Immunity vs.
3424:Autoantibody
3322:Superantigen
3169:Phagocytosis
3138:Reticulocyte
2946:
2912:Granulocytes
2863:Reticulocyte
2755:Promyelocyte
2718:Myelopoiesis
2633:. Retrieved
2629:the original
2598:
2594:
2584:
2567:
2563:
2553:
2516:
2512:
2502:
2467:
2463:
2453:
2426:
2422:
2412:
2385:
2381:
2371:
2328:
2324:
2314:
2281:
2277:
2270:
2229:
2225:
2219:
2184:
2180:
2174:
2139:
2135:
2125:
2090:
2086:
2076:
2041:
2035:
2005:(3): 520–7.
2002:
1998:
1992:
1967:
1963:
1925:
1921:
1915:
1882:
1876:
1849:
1845:
1835:
1810:
1806:
1800:
1775:
1771:
1765:
1732:
1728:
1684:
1680:
1670:
1635:
1631:
1621:
1589:(1): 43–56.
1586:
1582:
1572:
1539:
1535:
1528:
1511:
1507:
1501:
1466:
1462:
1452:
1433:
1427:
1400:
1396:
1335:(1): 45–56.
1332:
1328:
1286:
1280:
1245:
1241:
1200:(2): 68–79.
1197:
1193:
1166:. Retrieved
1162:
1153:
1141:. Retrieved
1137:the original
1132:
1123:
1078:Eosinophilia
1026:) tissue of
1021:
1008:benralizumab
999:lebrikizumab
992:
968:benralizumab
936:
927:
923:
900:L-tryptophan
866:; extensive
824:eosinophilia
821:
818:Eosinophilia
812:Eosinophilia
806:
729:
699:
686:nasal mucosa
683:
679:
647:pathogenesis
628:inflammation
617:
473:
440:leukotrienes
397:
329:
301:ribonuclease
283:, using the
267:: Normally
257:eosinophilic
250:
238:granulocytes
236:. They are
212:and certain
197:
194:eosinophiles
193:
189:
188:
3753:Human cells
3630:Lymphocytes
3289:Lymphocytic
3023:giant cells
3013:Osteoclasts
2993:Histiocytes
2985:Macrophages
2795:Promonocyte
2635:8 September
2536:2268/176693
2325:Respiration
1928:(1): 70–7.
1072:Eosinopenia
1004:Mepolizumab
981:antagonists
956:mepolizumab
803:Blood count
758:, suppress
516:leukotriene
512:eicosanoids
489:hypobromite
386:Development
368:lymph nodes
332:micrometres
313:plasminogen
269:transparent
246:bone marrow
218:vertebrates
190:Eosinophils
131:Identifiers
47:blood smear
3737:Categories
3671:Substances
3535:Peripheral
3523:Inaction:
3402:Antibodies
3383:Macrophage
3296:complement
2947:Eosinophil
2930:Neutrophil
2920:Myeloblast
2858:Normoblast
2750:Myeloblast
2653:Eosinophil
1263:1885/30451
1116:References
1036:macrophage
1030:deficient
960:reslizumab
944:– promote
896:penicillin
872:dermatitis
832:autoimmune
828:intestines
768:mast cells
732:neurotoxin
636:mast cells
550:) families
493:superoxide
468:epithelium
420:chemokines
222:mast cells
214:infections
198:acidophils
22:Eosinophil
3688:Cytolysin
3678:Cytokines
3525:Tolerance
3474:tolerance
3393:Immunogen
3230:Phagocyte
3097:Platelets
3076:Monoblast
3008:Microglia
2976:Monocytes
2959:Mast cell
2925:Band cell
2790:Monoblast
2770:Band cell
2760:Myelocyte
2345:0025-7931
2189:CiteSeerX
995:dupilumab
946:apoptosis
933:Treatment
848:malignant
838:(such as
788:apoptosis
740:antiviral
667:neoplasia
663:allograft
632:basophils
613:TNF alpha
577:Cytokines
514:from the
380:esophagus
307:(DNase),
303:(RNase),
293:cytoplasm
226:basophils
210:parasites
55:platelets
3727:Medicine
3638:Cellular
3482:Immunity
3480:Action:
3463:Paratope
3451:Idiotype
3441:Allotype
3409:Antibody
3363:Mimotope
3327:Allergen
3310:Antigens
3303:Lymphoid
3203:CFU-GEMM
2964:CFU-Mast
2940:CFU-Baso
2935:Basophil
2723:CFU-GEMM
2625:25934927
2545:25199059
2494:23866823
2445:21812663
2404:23688323
2363:38354723
2354:10997252
2306:11541968
2298:10469025
2211:15860794
2166:12043171
2117:33456907
2027:25152503
2019:15218055
1984:16551246
1907:23556551
1899:15947480
1868:11897981
1827:15609771
1792:15951020
1757:25254034
1749:18384431
1711:45301814
1703:17250693
1662:17351112
1493:20358022
1349:25521684
1272:17481712
1224:22379601
1143:27 March
1066:See also
1048:T. canis
1040:cytokine
987:imatinib
970:against
962:against
954:– e.g.,
894:such as
792:necrosis
760:antibody
744:basophil
651:helminth
579:such as
564:TGF beta
562:such as
555:elastase
497:peroxide
487:such as
458:Function
416:helminth
364:prostate
289:granules
279:, a red
273:staining
3715:Biology
3701:Portals
3683:Opsonin
3662:NK cell
3650:Humoral
3530:Central
3497:Allergy
3446:Isotype
3346:Epitope
3317:Antigen
3105:CFU-Meg
2952:CFU-Eos
2882:General
2616:4763864
2485:4172321
2262:4322838
2254:2423882
2234:Bibcode
2158:6206154
2109:3760576
2068:3538819
1942:9224211
1653:1890841
1613:3257253
1604:2188821
1556:3528176
1520:3493174
1484:2846745
1419:1596561
1357:5451867
1215:3283796
1168:14 June
1024:adipose
764:B cells
756:T cells
675:T cells
543:(e.g.,
518:(e.g.,
352:ovaries
350:tract,
336:medulla
244:in the
230:allergy
142:D004804
63:Details
3655:B cell
3643:T cell
3388:B cell
3351:Linear
3339:Hapten
3235:Plasma
3193:CFU-GM
3069:CFU-DL
2733:CFU-GM
2701:plasma
2623:
2613:
2543:
2492:
2482:
2443:
2402:
2361:
2351:
2343:
2304:
2296:
2260:
2252:
2226:Nature
2209:
2191:
2164:
2156:
2115:
2107:
2066:
2056:
2025:
2017:
1982:
1940:
1905:
1897:
1866:
1825:
1790:
1755:
1747:
1709:
1701:
1660:
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1611:
1601:
1564:515338
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1554:
1518:
1491:
1481:
1440:
1417:
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1347:
1293:
1270:
1222:
1212:
858:, and
842:) and
644:asthma
624:fibrin
620:RNases
611:, and
570:, and
539:) and
495:, and
432:RANTES
407:GATA-3
366:, and
360:spleen
356:uterus
344:thymus
340:cortex
315:, and
309:lipase
251:These
234:asthma
120:System
3223:Other
3183:Other
3148:CFU-E
3049:Other
2302:S2CID
2258:S2CID
2162:S2CID
2113:S2CID
2023:S2CID
1903:S2CID
1753:S2CID
1707:S2CID
1632:Blood
1560:S2CID
1397:Blood
1353:S2CID
1094:clone
1044:obese
892:drugs
738:with
726:(EDN)
720:(EPX)
714:(ECP)
708:(MBP)
609:IL-13
442:like
428:CCL24
424:CCL11
422:like
372:lungs
325:toxic
277:eosin
275:with
253:cells
177:[
166:62861
3294:and
2637:2016
2621:PMID
2541:PMID
2490:PMID
2441:PMID
2400:PMID
2359:PMID
2341:ISSN
2294:PMID
2250:PMID
2207:PMID
2154:PMID
2105:PMID
2064:PMID
2054:ISBN
2015:PMID
1980:PMID
1938:PMID
1895:PMID
1864:PMID
1823:PMID
1788:PMID
1745:PMID
1699:PMID
1658:PMID
1609:PMID
1552:PMID
1516:PMID
1489:PMID
1438:ISBN
1415:PMID
1345:PMID
1291:ISBN
1268:PMID
1220:PMID
1170:2018
1145:2018
1052:mRNA
1032:mice
1028:CCR2
1006:and
997:and
976:ADCC
964:IL-5
868:skin
834:and
790:and
778:and
734:are
642:and
634:and
605:IL-9
601:IL-8
597:IL-6
593:IL-5
589:IL-4
585:IL-2
581:IL-1
572:PDGF
568:VEGF
452:EGOT
411:IL-5
403:ILC2
401:and
376:skin
261:acid
259:or "
255:are
232:and
224:and
137:MeSH
3616:HLA
3612:MHC
3081:MPS
2811:MEP
2611:PMC
2603:doi
2572:doi
2568:152
2531:hdl
2521:doi
2517:371
2480:PMC
2472:doi
2468:132
2431:doi
2427:365
2390:doi
2386:368
2349:PMC
2333:doi
2329:103
2286:doi
2242:doi
2230:321
2199:doi
2144:doi
2140:133
2095:doi
2091:137
2046:doi
2007:doi
1972:doi
1930:doi
1887:doi
1854:doi
1850:109
1815:doi
1780:doi
1776:107
1737:doi
1689:doi
1648:PMC
1640:doi
1636:109
1599:PMC
1591:doi
1587:167
1544:doi
1540:128
1479:PMC
1471:doi
1405:doi
1337:doi
1258:hdl
1250:doi
1246:119
1210:PMC
1202:doi
1060:TH1
1056:TH2
958:or
874:);
754:of
673:to
545:PGE
534:LTE
527:LTD
520:LTC
434:),
399:TH2
281:dye
216:in
161:FMA
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