304:
281:
203:
178:
555:
310:
209:
31:
2903:
1389:
Prior to its discovery in 2000, it was hypothesized that a protein existed which performed the functions subsequently shown for FGF23. This putative protein was known as phosphatonin. Several types of effects were described including impairment of sodium dependent phosphate transport in both
57:
1564:
Perwad F, Zhang MY, Tenenhouse HS, Portale AA (November 2007). "Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro".
317:
216:
1242:
FGF23´s main function is to regulate the phosphate concentration in plasma. It does this by decreasing reabsorption of phosphate in the kidney, which means phosphate is excreted in urine. FGF23 is secreted by
2423:
White KE, Evans WE, O'Riordan JL, Speer MC, Econs MJ, Lorenz-Depiereux B, et al. (ADHR Consortium) (November 2000). "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23".
1363:
Over-expression of FGF23 has been associated with cardiovascular disease in chronic kidney disease including cardiomyocyte hypertrophy, vascular calcification, stroke, and endothelial dysfunction.
1390:
intestinal and renal brush border membrane vesicles, inhibition of production of calcitriol, stimulation of breakdown of calcitriol, and inhibition of production/secretion of parathyroid hormone.
2806:"Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein"
1485:
Yamashita T, Yoshioka M, Itoh N (October 2000). "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain".
5644:
5664:
5654:
3433:
3809:
2549:
Bowe AE, Finnegan R, Jan de Beur SM, Cho J, Levine MA, Kumar R, et al. (June 2001). "FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate".
2736:"The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency"
5639:
2613:
Kruse K, Woelfel D, Strom TM (2002). "Loss of renal phosphate wasting in a child with autosomal dominant hypophosphatemic rickets caused by a FGF23 mutation".
2656:
4174:
898:
139:
879:
5409:
3484:
5348:
4525:
3717:
3426:
6308:
4450:
2701:"Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production"
6032:
5945:
5890:
5844:
5789:
5524:
5464:
4465:
4395:
3954:
3552:
3494:
1467:
2463:"The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting"
1449:
6027:
5905:
5804:
5590:
5479:
5279:
5239:
4987:
4906:
4768:
4709:
4671:
4616:
4611:
4601:
4475:
4470:
4440:
4415:
4410:
4400:
4286:
4205:
4144:
4072:
4051:
4036:
3989:
3642:
1373:
FGF23 is associated with at least 7 non-nutritional diseases of hypophosphatemia: aside from autosomal dominant hypophosphatemic rickets,
6127:
5985:
5964:
5920:
5900:
5819:
5799:
5514:
5494:
5474:
5117:
5112:
4445:
4169:
3702:
3499:
1316:
1296:
1198:
5950:
5940:
5895:
5849:
5839:
5794:
5618:
5585:
5565:
5529:
5519:
5469:
5429:
4901:
4881:
4848:
4729:
4631:
4480:
3419:
2850:
2666:"Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway"
1609:
1105:
5910:
5809:
5704:
5608:
5560:
5553:
5539:
5484:
5454:
4934:
4924:
4876:
4858:
4787:
4621:
4460:
4405:
1760:
Brown RB, Razzaque MS (January 2018). "Chapter 31 - Endocrine
Regulation of Phosphate Homeostasis". In Singh AK, Williams GH (eds.).
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5649:
5339:
2943:
1263:
4944:
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5749:
3929:
3612:
3297:
3292:
3168:
2314:
Fukagawa M, Nii-Kono T, Kazama JJ (July 2005). "Role of fibroblast growth factor 23 in health and in chronic kidney disease".
6365:
6327:
6277:
6248:
6195:
4682:
4549:
2882:
1787:
1432:
6006:
6002:
5998:
5994:
3547:
3531:
3369:
3364:
3359:
54:
4275:
4194:
4061:
3978:
1411:
5990:
3351:
6370:
5679:
4798:
4358:
3969:
2971:
1348:
Loss of FGF23 activity is thought to lead to increased phosphate levels and the clinical syndrome of familial tumor
303:
3627:
3571:
3562:
1703:"Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1"
6201:
3257:
3186:
2285:
Quarles LD (July 2003). "FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization".
1436:
1415:
280:
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5404:
4960:
4823:
3318:
2986:
1334:
1252:
943:
2902:
6254:
1522:"Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23"
202:
177:
924:
6298:
4694:
4576:
4566:
3245:
3240:
2936:
119:
5669:
3374:
1925:
Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten paraneoplastic syndrome?".
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3213:
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Beck-Nielsen SS, Mughal Z, Haffner D, Nilsson O, Levtchenko E, Ariceta G, et al. (February 2019).
1378:
1338:
309:
208:
6191:
2875:
1374:
1311:, which render the protein resistant to proteolytic cleavage, lead to its increased activity and to
106:
4375:
4291:
4210:
4077:
3994:
3400:
2960:
1223:
1169:
127:
5975:
3722:
3597:
3379:
3163:
2929:
2256:
Silve C, Beck L (June 2002). "Is FGF23 the long sought after phosphaturic factor phosphatonin?".
1342:
2351:
Imel EA, Econs MJ (September 2005). "Fibroblast growth factor 23: roles in health and disease".
1081:
1060:
1034:
1013:
6259:
5875:
5779:
5399:
4818:
3804:
3442:
2461:
White KE, Jonsson KB, Carn G, Hampson G, Spector TD, Mannstadt M, et al. (February 2001).
1280:
1215:
1186:
6333:
4530:
3814:
3453:
2771:"Immunohistochemical detection of FGF-23 protein in tumors that cause oncogenic osteomalacia"
2650:
2108:"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production"
191:
769:
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
6273:
5659:
4591:
4540:
2868:
2509:
2498:"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia"
1960:
Green D, Mohorianu I, Piec I, Turner J, Beadsmoore C, Toms A, et al. (December 2017).
1714:
147:
1669:
8:
5414:
4828:
3395:
2804:
Campos M, Couture C, Hirata IY, Juliano MA, Loisel TP, Crine P, et al. (July 2003).
2578:
White KE, Carn G, Lorenz-Depiereux B, Benet-Pages A, Strom TM, Econs MJ (December 2001).
2513:
2106:
David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, et al. (January 2016).
1718:
5092:
3445:
2830:
2805:
2769:
Larsson T, Zahradnik R, Lavigne J, Ljunggren O, Jüppner H, Jonsson KB (February 2003).
2638:
2449:
2376:
2339:
2327:
2239:
2214:
2134:
2107:
2083:
2056:
1988:
1961:
1938:
1888:
1861:
1837:
1812:
1793:
1769:
1737:
1702:
1678:
1653:
1627:
1590:
151:
2699:
Saito H, Kusano K, Kinosaki M, Ito H, Hirata M, Segawa H, et al. (January 2003).
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
657:
652:
647:
642:
626:
621:
616:
611:
606:
601:
596:
5719:
2835:
2792:
2757:
2722:
2687:
2630:
2601:
2596:
2579:
2566:
2537:
2532:
2497:
2484:
2441:
2411:
2368:
2331:
2302:
2273:
2244:
2190:
2185:
2158:
2139:
2088:
2034:
1993:
1942:
1893:
1842:
1797:
1783:
1742:
1683:
1631:
1582:
1543:
1538:
1521:
1502:
1357:
99:
47:
3411:
2642:
2453:
2343:
2215:"Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis"
1594:
131:
6137:
5269:
2825:
2817:
2782:
2747:
2712:
2677:
2622:
2591:
2558:
2527:
2517:
2496:
Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, et al. (May 2001).
2474:
2433:
2401:
2380:
2360:
2323:
2294:
2265:
2234:
2226:
2180:
2170:
2129:
2119:
2078:
2068:
2024:
1983:
1973:
1934:
1883:
1873:
1832:
1824:
1773:
1765:
1732:
1722:
1673:
1665:
1617:
1574:
1533:
1494:
1353:
396:
327:
271:
226:
1878:
3150:
1367:
1256:
1251:
and phosphate. FGF23 acts on the kidneys by decreasing the expression of NPT2, a
371:
155:
1578:
1472:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1454:
National Center for
Biotechnology Information, U.S. National Library of Medicine
6323:
6244:
6186:
5880:
5729:
5724:
4838:
4833:
3479:
3469:
3464:
2580:"Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23"
2502:
Proceedings of the
National Academy of Sciences of the United States of America
2298:
2230:
2163:
Proceedings of the
National Academy of Sciences of the United States of America
1978:
1707:
Proceedings of the
National Academy of Sciences of the United States of America
472:
2073:
1622:
6359:
6017:
5930:
5859:
5829:
5764:
5674:
5628:
5504:
5434:
5379:
5368:
4853:
4561:
4244:
4149:
4041:
2952:
2854:
1288:
1181:
583:
2013:"Regulation of ion channels by secreted Klotho: mechanisms and implications"
1727:
554:
532:
410:
6343:
6313:
6052:
6042:
5935:
5834:
5689:
5509:
5444:
5359:
4863:
4666:
4505:
4500:
4420:
4370:
4184:
3938:
3919:
3898:
3869:
3592:
3587:
2839:
2796:
2761:
2752:
2735:
2726:
2717:
2700:
2691:
2682:
2665:
2634:
2605:
2570:
2562:
2541:
2522:
2488:
2479:
2462:
2445:
2415:
2406:
2389:
2372:
2364:
2335:
2306:
2277:
2269:
2248:
2194:
2143:
2092:
2038:
1997:
1946:
1897:
1846:
1746:
1701:
Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, Huang CL (July 2008).
1687:
1586:
1547:
1506:
1498:
389:
168:
2787:
2770:
2175:
1145:
1140:
6303:
6269:
6167:
6157:
6152:
6142:
6092:
5915:
5814:
5575:
5489:
5419:
5314:
5077:
5042:
4992:
4955:
4891:
4773:
4704:
4656:
4646:
4641:
4636:
4520:
4515:
4510:
3888:
3799:
3789:
3757:
3752:
3747:
3742:
3732:
3692:
3657:
1330:
1193:. FGF-23 decreases reabsorption of phosphate in the kidney. Mutations in
988:
969:
30:
2124:
6122:
6087:
6082:
6072:
6062:
5980:
5769:
5744:
5734:
5580:
5534:
5394:
5220:
5189:
5158:
5127:
5072:
5047:
5027:
5012:
5002:
4896:
4813:
4606:
4586:
4485:
4430:
4425:
4249:
4154:
4139:
3934:
3893:
3865:
3834:
3794:
3697:
3652:
3647:
3622:
3617:
3607:
3520:
3514:
3504:
3201:
3196:
3191:
2821:
2029:
2012:
1828:
1778:
1349:
1248:
288:
185:
135:
2626:
2219:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
76:
6147:
6117:
6112:
6107:
6102:
6097:
6077:
6067:
6057:
6047:
5739:
5699:
5595:
5570:
5329:
5324:
5319:
5309:
5304:
5299:
5289:
5210:
5148:
5082:
5062:
5057:
5052:
5037:
5032:
5022:
5017:
4911:
4886:
4651:
4571:
4490:
4435:
4325:
4264:
4254:
4159:
4046:
3844:
3839:
3829:
3737:
3727:
3712:
3687:
3682:
3672:
3667:
3662:
3302:
3158:
1267:
1244:
1231:
1227:
1177:
1173:
843:
355:
342:
254:
241:
143:
2577:
2159:"FGF23, hypophosphatemia, and rickets: has phosphatonin been found?"
110:, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
6318:
6037:
5694:
5294:
5284:
5264:
5007:
4997:
4344:
3824:
3767:
3677:
3637:
3112:
2057:"FGF23 and its role in X-linked hypophosphatemia-related morbidity"
1129:
5199:
5168:
5137:
5101:
2437:
6293:
5714:
5179:
4581:
3542:
3287:
3226:
2921:
1377:, autosomal recessive hypophosphatemic rickets type 1, 2, and 3,
1210:
1165:
955:
910:
828:
824:
2768:
2664:
Yamashita T, Konishi M, Miyake A, Inui K, Itoh N (August 2002).
2054:
123:
6206:
5870:
5759:
5684:
5389:
5384:
4808:
4803:
4757:
4753:
4749:
4745:
4741:
4737:
4733:
4385:
3924:
3602:
1327:
1312:
1113:
865:
563:
2860:
6238:
6234:
6230:
6226:
6222:
6218:
6214:
6210:
5925:
5824:
5499:
5439:
5253:
4976:
4972:
4968:
4964:
4455:
4319:
4238:
4234:
4133:
4129:
4125:
4121:
4030:
4026:
3877:
3341:
3336:
3331:
3326:
3282:
3277:
3272:
3267:
3131:
3126:
3121:
3097:
3091:
3085:
3079:
3059:
3055:
3046:
3042:
3033:
3029:
1323:
2422:
2287:
American
Journal of Physiology. Endocrinology and Metabolism
1563:
5709:
4315:
4311:
4307:
4303:
4299:
4295:
4230:
4226:
4222:
4218:
4214:
4117:
4113:
4105:
4101:
4097:
4093:
4089:
4085:
4081:
4022:
4018:
4014:
4010:
4006:
4002:
3998:
3950:
3946:
3942:
3908:
3873:
3854:
3051:
3038:
3025:
3003:
2999:
2995:
2990:
2982:
2105:
1295:. The gene was identified by its mutations associated with
1292:
1284:
1219:
1190:
2803:
2663:
2548:
1962:"MicroRNA expression in a phosphaturic mesenchymal tumour"
2495:
1700:
1959:
1859:
754:
positive regulation of vitamin D 24-hydroxylase activity
379:
2733:
2460:
617:
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
6309:
Pituitary adenylate cyclase-activating peptide (PACAP)
2734:
Bai XY, Miao D, Goltzman D, Karaplis AC (March 2003).
2698:
2313:
3441:
1764:(Second ed.). Academic Press. pp. 539–548.
1484:
1172:(FGF) family which participates in the regulation of
794:
phosphatidylinositol-3-phosphate biosynthetic process
544:
2467:
The
Journal of Clinical Endocrinology and Metabolism
2551:
1610:"Fun facts about bones: More than just scaffolding"
1487:
Biochemical and Biophysical Research Communications
784:
phosphatidylinositol phosphate biosynthetic process
739:
fibroblast growth factor receptor signaling pathway
734:
positive regulation of transcription, DNA-templated
6255:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5113:Glial cell line-derived neurotrophic factor (GDNF)
4766:Cleavage products/derivatives with unknown target:
1428:
1426:
1424:
1407:
1405:
1403:
1381:and Hypophosphatemic rickets with hypercalciuria.
2655:: CS1 maint: DOI inactive as of September 2024 (
2612:
1197:can lead to its increased activity, resulting in
814:positive regulation of protein kinase B signaling
774:cellular response to parathyroid hormone stimulus
724:negative regulation of osteoblast differentiation
326:
225:
6357:
6289:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1912:"Entrez Gene: FGF23 fibroblast growth factor 23"
1567:American Journal of Physiology. Renal Physiology
1322:FGF23 can also be overproduced by some types of
602:type 1 fibroblast growth factor receptor binding
3930:Heparin-binding EGF-like growth factor (HB-EGF)
3613:Heparin-binding EGF-like growth factor (HB-EGF)
2050:
2048:
1651:
1421:
1400:
1270:and subsequently impairing calcium absorption.
759:phosphate-containing compound metabolic process
2316:Current Opinion in Nephrology and Hypertension
1559:
1557:
1433:GRCm38: Ensembl release 89: ENSMUSG00000000182
6341:Additional growth factor receptor modulators:
3427:
2937:
2876:
2394:Journal of the American Society of Nephrology
2353:Journal of the American Society of Nephrology
1759:
1366:FGF23 expression and cleavage is promoted by
4695:Insulin-like growth factor-2 (somatomedin A)
4577:Insulin-like growth factor-2 (somatomedin A)
4567:Insulin-like growth factor-1 (somatomedin C)
2212:
2045:
2004:
1953:
1853:
1804:
1694:
749:positive regulation of ERK1 and ERK2 cascade
1924:
1554:
1513:
1478:
1412:GRCh38: Ensembl release 89: ENSG00000118972
1317:autosomal dominant hypophosphatemic rickets
1297:autosomal dominant hypophosphatemic rickets
1199:autosomal dominant hypophosphatemic rickets
3434:
3420:
2944:
2930:
2883:
2869:
2851:United States National Library of Medicine
2387:
679:negative regulation of bone mineralization
2829:
2786:
2751:
2716:
2681:
2595:
2531:
2521:
2478:
2405:
2350:
2255:
2238:
2184:
2174:
2133:
2123:
2082:
2072:
2028:
1987:
1977:
1887:
1877:
1836:
1777:
1736:
1726:
1677:
1652:Robling AG, Bonewald LF (February 2020).
1621:
1537:
1209:Fibroblast growth factor 23 (FGF23) is a
809:regulation of signaling receptor activity
597:fibroblast growth factor receptor binding
6299:Migration-stimulating factor (MSF; PRG4)
2849:This article incorporates text from the
2156:
1860:Rodríguez-Ortiz ME, Rodríguez M (2015).
1519:
1302:
779:negative regulation of hormone secretion
622:1-phosphatidylinositol-3-kinase activity
3628:Transforming growth factor alpha (TGFα)
2390:"How fibroblast growth factor 23 works"
2284:
1810:
804:post-translational protein modification
6358:
6202:Connective tissue growth factor (CTGF)
1904:
1645:
6265:Hepatoma-derived growth factor (HDGF)
3415:
2925:
2864:
2258:Nephrology, Dialysis, Transplantation
2213:Kiela PR, Ghishan FK (January 2009).
2099:
2010:
1670:10.1146/annurev-physiol-021119-034332
1607:
1315:phosphate loss, in the human disease
331:
292:
287:
230:
189:
184:
1601:
729:cellular response to leptin stimulus
2740:The Journal of Biological Chemistry
2705:The Journal of Biological Chemistry
2670:The Journal of Biological Chemistry
1918:
1352:. Mice lacking either FGF23 or the
1266:, reducing its ability to activate
1226:(FGF) family which participates in
13:
2951:
2911:: Crystal structure of human FGF23
2328:10.1097/01.mnh.0000172717.49476.80
2205:
1939:10.1016/j.oraloncology.2011.09.011
1770:10.1016/b978-0-12-803247-3.00032-5
1278:In humans FGF23 is encoded by the
1213:which in humans is encoded by the
704:cellular phosphate ion homeostasis
684:cellular response to interleukin-6
14:
6382:
2775:European Journal of Endocrinology
2061:Orphanet Journal of Rare Diseases
1862:"FGF23 as a calciotropic hormone"
789:peptidyl-tyrosine phosphorylation
714:regulation of phosphate transport
694:regulation of bone mineralization
6284:Leukemia inhibitory factor (LIF)
2901:
2597:10.1046/j.1523-1755.2001.00064.x
1817:Kidney International. Supplement
1762:Textbook of Nephro-Endocrinology
1539:10.2169/internalmedicine.47.0730
612:protein tyrosine kinase activity
553:
495:lumbar subsegment of spinal cord
315:
308:
302:
279:
214:
207:
201:
176:
29:
5452:Negative allosteric modulators:
3258:Relaxin family peptide hormones
2890:
2388:Liu S, Quarles LD (June 2007).
2150:
1753:
5770:Gossypetin (3,5,7,8,3',4'-HHF)
4961:Platelet-derived growth factor
1460:
1442:
1356:enzyme age prematurely due to
1335:phosphaturic mesenchymal tumor
1253:sodium-phosphate cotransporter
1204:
719:cellular response to vitamin D
564:More reference expression data
533:More reference expression data
1:
5976:Placental growth factor (PGF)
1879:10.12688/f1000research.7189.1
1654:"The Osteocyte: New Insights"
1393:
300:
199:
6366:Genes on human chromosome 12
6260:Glia maturation factor (GMF)
4769:Glypromate (GPE, (1-3)IGF-1)
1608:Dance A (23 February 2022).
1180:metabolism. In humans it is
744:response to sodium phosphate
7:
1658:Annual Review of Physiology
1579:10.1152/ajprenal.00463.2006
1273:
1237:
1234:metabolism and regulation.
1222:. FGF23 is a member of the
1158:Fibroblast growth factor 23
764:vitamin D catabolic process
689:vitamin D metabolic process
653:endoplasmic reticulum lumen
10:
6387:
6192:Colony-stimulating factors
6184:Additional growth factors:
3231:Insulin-like growth factor
2299:10.1152/ajpendo.00016.2003
2231:10.1038/labinvest.2008.114
1979:10.1016/j.bonr.2017.09.001
1384:
1379:Tumor-induced osteomalacia
1339:tumor-induced osteomalacia
6176:
5963:
5858:
5627:
5540:SNA-120 (pegylated K252a)
5367:
5358:
5338:
5252:
5229:
5198:
5167:
5136:
5100:
5091:
4943:
4786:
4719:
4712:(against IGF-1 and IGF-2)
4681:
4674:(against IGF-1 and IGF-2)
4548:
4539:
4357:
4334:
4274:
4193:
4060:
3977:
3968:
3907:
3853:
3766:
3570:
3561:
3530:
3452:
3388:
3350:
3317:
3254:
3223:
3212:
3177:
3149:
3107:
3068:
3012:
2968:
2959:
2896:
2074:10.1186/s13023-019-1014-8
1623:10.1146/knowable-022222-1
1468:"Mouse PubMed Reference:"
1450:"Human PubMed Reference:"
1375:X-linked hypophosphatemia
1291:and is composed of three
1247:in response to increased
1144:
1139:
1135:
1128:
1112:
1106:Chr 6: 127.05 – 127.06 Mb
1093:
1078:
1074:
1057:
1053:
1046:
1031:
1027:
1010:
1006:
999:
986:
982:
967:
963:
954:
941:
937:
922:
918:
909:
896:
892:
877:
873:
864:
849:
842:
838:
822:
709:response to magnesium ion
699:phosphate ion homeostasis
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
6371:Fibroblast growth factor
4376:Hepatocyte growth factor
3935:Neuregulins (heregulins)
3866:Neuregulins (heregulins)
3810:Trastuzumab duocarmazine
3523:(against angiopoietin 2)
3517:(against angiopoietin 3)
2157:Strewler GJ (May 2001).
1811:Jüppner H (April 2011).
1262:FGF23 may also suppress
1224:fibroblast growth factor
1170:fibroblast growth factor
3723:Depatuxizumab mafodotin
3071:FGF homologous factors:
2810:The Biochemical Journal
2629:(inactive 2024-09-21).
1728:10.1073/pnas.0803223105
1343:paraneoplastic syndrome
511:vastus lateralis muscle
16:Protein found in humans
6346:(neurotrophin mixture)
6334:Wnt signaling proteins
6015:Allosteric modulators:
5735:Norwogonin (5,7,8-THF)
3955:5 (tomoregulin, TMEFF)
3805:Trastuzumab deruxtecan
3443:Growth factor receptor
2753:10.1074/jbc.M210490200
2718:10.1074/jbc.M207872200
2683:10.1074/jbc.M202527200
2563:10.1006/bbrc.2001.5084
2523:10.1073/pnas.101545198
2480:10.1210/jcem.86.2.7408
2407:10.1681/ASN.2007010068
2365:10.1681/ASN.2005050573
1813:"Phosphate and FGF-23"
1499:10.1006/bbrc.2000.3696
1287:, which is located on
1099:Chr 12: 4.37 – 4.38 Mb
607:growth factor activity
503:superior frontal gyrus
487:lumbar spinal ganglion
6274:T-cell growth factors
4531:Telisotuzumab vedotin
3815:Trastuzumab emtansine
2788:10.1530/eje.0.1480269
2176:10.1073/pnas.11154898
2011:Huang CL (May 2010).
1303:Clinical significance
453:primary visual cortex
192:Chromosome 12 (human)
4859:EVT-901 (SAR-127963)
4592:Mecasermin rinfabate
3352:Vascular endothelial
2584:Kidney International
2270:10.1093/ndt/17.6.958
2112:Kidney International
2017:Kidney International
674:cell differentiation
643:extracellular region
519:major salivary gland
294:Chromosome 6 (mouse)
69:List of PDB id codes
42:Available structures
2676:(31): 28265–28270.
2514:2001PNAS...98.6500S
2125:10.1038/ki.2015.290
1719:2008PNAS..105.9805C
1520:Fukumoto S (2008).
1264:1-alpha-hydroxylase
658:extracellular space
441:right lobe of liver
6025:Kinase inhibitors:
5888:Kinase inhibitors:
5787:Kinase inhibitors:
5462:Kinase inhibitors:
5277:Kinase inhibitors:
5237:Kinase inhibitors:
5218:Kinase inhibitors:
5187:Kinase inhibitors:
5156:Kinase inhibitors:
5125:Kinase inhibitors:
4985:Kinase inhibitors:
4599:Kinase inhibitors:
4393:Kinase inhibitors:
4182:Kinase inhibitors:
4175:Aprutumab ixadotin
3822:Kinase inhibitors:
3635:Kinase inhibitors:
3492:Kinase inhibitors:
2853:, which is in the
2822:10.1042/BJ20030287
2030:10.1038/ki.2010.73
1829:10.1038/ki.2011.27
1573:(5): F1577–F1583.
1370:and inflammation.
1168:and member of the
944:ENSMUSG00000000182
667:Biological process
636:Cellular component
590:Molecular function
507:extraocular muscle
499:tibiofemoral joint
6353:
6352:
5959:
5958:
5720:N-Acetylserotonin
5619:ReN-1820 (TrkAd5)
5248:
5247:
4782:
4781:
4727:Binding proteins:
4386:Dihexa (PNB-0408)
4353:
4352:
3964:
3963:
3878:6 (neuroglycan C)
3598:EGF (urogastrone)
3576:
3409:
3408:
3313:
3312:
3145:
3144:
2919:
2918:
2816:(Pt 1): 271–279.
2746:(11): 9843–9849.
2627:10.1159/000050018
2508:(11): 6500–6505.
2169:(11): 5945–5946.
1789:978-0-12-803247-3
1713:(28): 9805–9810.
1614:Knowable Magazine
1526:Internal Medicine
1358:hyperphosphatemia
1155:
1154:
1151:
1150:
1124:
1123:
1089:
1088:
1068:
1067:
1042:
1041:
1021:
1020:
995:
994:
976:
975:
950:
949:
931:
930:
905:
904:
886:
885:
834:
833:
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
156:FGF23 - orthologs
88:
87:
84:
83:
52:Ortholog search:
6378:
6165:Decoy receptors:
6138:Alacizumab pegol
5616:Decoy receptors:
5365:
5364:
5270:Stem cell factor
5211:Persephin (PSPN)
5149:Neurturin (NRTN)
5098:
5097:
4935:LEVI-04 (p75-Fc)
4932:Decoy receptors:
4546:
4545:
3975:
3974:
3574:
3568:
3567:
3436:
3429:
3422:
3413:
3412:
3319:Platelet-derived
3261:
3234:
3221:
3220:
3115:
3073:
3019:
2976:
2966:
2965:
2946:
2939:
2932:
2923:
2922:
2905:
2885:
2878:
2871:
2862:
2861:
2843:
2833:
2800:
2790:
2765:
2755:
2730:
2720:
2711:(4): 2206–2211.
2695:
2685:
2660:
2654:
2646:
2615:Hormone Research
2609:
2599:
2590:(6): 2079–2086.
2574:
2545:
2535:
2525:
2492:
2482:
2457:
2419:
2409:
2400:(6): 1637–1647.
2384:
2359:(9): 2565–2575.
2347:
2310:
2281:
2252:
2242:
2199:
2198:
2188:
2178:
2154:
2148:
2147:
2137:
2127:
2103:
2097:
2096:
2086:
2076:
2052:
2043:
2042:
2032:
2008:
2002:
2001:
1991:
1981:
1957:
1951:
1950:
1922:
1916:
1915:
1908:
1902:
1901:
1891:
1881:
1857:
1851:
1850:
1840:
1823:(121): S24–S27.
1808:
1802:
1801:
1781:
1757:
1751:
1750:
1740:
1730:
1698:
1692:
1691:
1681:
1649:
1643:
1642:
1640:
1638:
1625:
1605:
1599:
1598:
1561:
1552:
1551:
1541:
1517:
1511:
1510:
1482:
1476:
1475:
1464:
1458:
1457:
1446:
1440:
1430:
1419:
1409:
1137:
1136:
1108:
1101:
1084:
1072:
1071:
1063:
1051:
1050:
1047:RefSeq (protein)
1037:
1025:
1024:
1016:
1004:
1003:
980:
979:
961:
960:
935:
934:
916:
915:
890:
889:
871:
870:
840:
839:
580:
579:
566:
557:
550:
549:
535:
475:
473:Top expressed in
468:
467:
413:
411:Top expressed in
406:
405:
385:
384:
368:
367:
358:
345:
334:
319:
312:
306:
295:
283:
267:
266:
257:
244:
233:
218:
211:
205:
194:
180:
164:
163:
158:
109:
102:
79:
66:
65:
60:
39:
38:
33:
21:
20:
6386:
6385:
6381:
6380:
6379:
6377:
6376:
6375:
6356:
6355:
6354:
6349:
6294:Midkine (NEGF2)
6172:
5955:
5854:
5623:
5561:ABT-110 (PG110)
5354:
5334:
5244:
5225:
5194:
5163:
5132:
5087:
4939:
4877:ABT-110 (PG110)
4778:
4715:
4677:
4535:
4349:
4330:
4270:
4267:(against FGF23)
4189:
4056:
3960:
3903:
3849:
3762:
3573:
3557:
3526:
3448:
3440:
3410:
3405:
3384:
3346:
3309:
3255:
3250:
3224:
3215:
3208:
3173:
3151:EGF-like domain
3141:
3108:
3103:
3069:
3064:
3013:
3008:
2969:
2955:
2950:
2920:
2915:
2912:
2906:
2892:
2889:
2846:
2648:
2647:
2426:Nature Genetics
2208:
2206:Further reading
2203:
2202:
2155:
2151:
2104:
2100:
2053:
2046:
2023:(10): 855–860.
2009:
2005:
1958:
1954:
1923:
1919:
1910:
1909:
1905:
1858:
1854:
1809:
1805:
1790:
1758:
1754:
1699:
1695:
1650:
1646:
1636:
1634:
1606:
1602:
1562:
1555:
1518:
1514:
1483:
1479:
1466:
1465:
1461:
1448:
1447:
1443:
1431:
1422:
1410:
1401:
1396:
1387:
1368:iron deficiency
1305:
1276:
1257:proximal tubule
1240:
1207:
1146:View/Edit Mouse
1141:View/Edit Human
1104:
1097:
1094:Location (UCSC)
1080:
1059:
1033:
1012:
925:ENSG00000118972
818:
662:
631:
627:protein binding
562:
531:
522:
517:
513:
509:
505:
501:
497:
493:
489:
485:
471:
460:
455:
451:
447:
445:muscle of thigh
443:
439:
435:
431:
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
118:
105:
98:
75:
53:
17:
12:
11:
5:
6384:
6374:
6373:
6368:
6351:
6350:
6348:
6347:
6337:
6336:
6331:
6324:Thrombopoietin
6321:
6316:
6311:
6306:
6301:
6296:
6291:
6286:
6281:
6267:
6262:
6257:
6252:
6245:Erythropoietin
6242:
6204:
6199:
6189:
6187:Adrenomedullin
6180:
6178:
6174:
6173:
6171:
6170:
6161:
6160:
6155:
6150:
6145:
6140:
6131:
6130:
6125:
6120:
6115:
6110:
6105:
6100:
6095:
6090:
6085:
6080:
6075:
6070:
6065:
6060:
6055:
6050:
6045:
6040:
6035:
6030:
6021:
6020:
6011:
6010:
5988:
5983:
5978:
5969:
5967:
5961:
5960:
5957:
5956:
5954:
5953:
5948:
5943:
5938:
5933:
5928:
5923:
5918:
5913:
5908:
5903:
5898:
5893:
5884:
5883:
5878:
5873:
5864:
5862:
5856:
5855:
5853:
5852:
5847:
5842:
5837:
5832:
5827:
5822:
5817:
5812:
5807:
5802:
5797:
5792:
5783:
5782:
5773:
5772:
5767:
5762:
5753:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5712:
5707:
5702:
5697:
5692:
5687:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5650:4'-DMA-7,8-DHF
5647:
5642:
5633:
5631:
5625:
5624:
5622:
5621:
5612:
5611:
5599:
5598:
5593:
5588:
5583:
5578:
5573:
5568:
5563:
5544:
5543:
5537:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5492:
5487:
5482:
5477:
5472:
5467:
5458:
5457:
5448:
5447:
5442:
5437:
5432:
5423:
5422:
5417:
5412:
5410:Gambogic amide
5407:
5402:
5397:
5392:
5387:
5382:
5373:
5371:
5362:
5356:
5355:
5353:
5352:
5344:
5342:
5336:
5335:
5333:
5332:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5273:
5272:
5267:
5258:
5256:
5250:
5249:
5246:
5245:
5243:
5242:
5233:
5231:
5227:
5226:
5224:
5223:
5214:
5213:
5204:
5202:
5196:
5195:
5193:
5192:
5183:
5182:
5180:Artemin (ARTN)
5173:
5171:
5165:
5164:
5162:
5161:
5152:
5151:
5142:
5140:
5134:
5133:
5131:
5130:
5121:
5120:
5115:
5106:
5104:
5095:
5089:
5088:
5086:
5085:
5080:
5075:
5066:
5065:
5060:
5055:
5050:
5045:
5040:
5035:
5030:
5025:
5020:
5015:
5010:
5005:
5000:
4995:
4990:
4981:
4980:
4958:
4949:
4947:
4941:
4940:
4938:
4937:
4928:
4927:
4915:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4867:
4866:
4861:
4856:
4851:
4842:
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4792:
4790:
4784:
4783:
4780:
4779:
4777:
4776:
4771:
4762:
4761:
4723:
4721:
4717:
4716:
4714:
4713:
4707:
4698:
4697:
4687:
4685:
4679:
4678:
4676:
4675:
4669:
4664:
4659:
4654:
4649:
4644:
4639:
4634:
4625:
4624:
4619:
4614:
4609:
4604:
4595:
4594:
4589:
4584:
4579:
4574:
4569:
4564:
4554:
4552:
4543:
4537:
4536:
4534:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4494:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4389:
4388:
4379:
4378:
4373:
4363:
4361:
4355:
4354:
4351:
4350:
4348:
4347:
4338:
4336:
4332:
4331:
4329:
4328:
4323:
4289:
4280:
4278:
4272:
4271:
4269:
4268:
4258:
4257:
4252:
4247:
4242:
4208:
4199:
4197:
4191:
4190:
4188:
4187:
4178:
4177:
4172:
4163:
4162:
4157:
4152:
4147:
4142:
4137:
4075:
4066:
4064:
4058:
4057:
4055:
4054:
4049:
4044:
4039:
4034:
3992:
3983:
3981:
3972:
3966:
3965:
3962:
3961:
3959:
3958:
3932:
3927:
3922:
3913:
3911:
3905:
3904:
3902:
3901:
3896:
3891:
3882:
3881:
3859:
3857:
3851:
3850:
3848:
3847:
3842:
3837:
3832:
3827:
3818:
3817:
3812:
3807:
3802:
3797:
3792:
3783:
3782:
3772:
3770:
3764:
3763:
3761:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3706:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3631:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3580:
3578:
3565:
3559:
3558:
3556:
3555:
3550:
3545:
3536:
3534:
3528:
3527:
3525:
3524:
3518:
3508:
3507:
3502:
3497:
3488:
3487:
3485:Angiopoietin 3
3482:
3480:Angiopoietin 2
3473:
3472:
3470:Angiopoietin 4
3467:
3465:Angiopoietin 1
3458:
3456:
3450:
3449:
3439:
3438:
3431:
3424:
3416:
3407:
3406:
3404:
3403:
3398:
3392:
3390:
3386:
3385:
3383:
3382:
3377:
3372:
3367:
3362:
3356:
3354:
3348:
3347:
3345:
3344:
3339:
3334:
3329:
3323:
3321:
3315:
3314:
3311:
3310:
3308:
3307:
3306:
3305:
3300:
3295:
3285:
3280:
3275:
3270:
3264:
3262:
3252:
3251:
3249:
3248:
3243:
3237:
3235:
3218:
3216:Relaxin family
3210:
3209:
3207:
3206:
3205:
3204:
3199:
3194:
3183:
3181:
3175:
3174:
3172:
3171:
3166:
3161:
3155:
3153:
3147:
3146:
3143:
3142:
3140:
3139:
3134:
3129:
3124:
3118:
3116:
3105:
3104:
3102:
3101:
3095:
3089:
3083:
3076:
3074:
3066:
3065:
3063:
3062:
3049:
3036:
3022:
3020:
3010:
3009:
3007:
3006:
2993:
2979:
2977:
2963:
2957:
2956:
2953:Growth factors
2949:
2948:
2941:
2934:
2926:
2917:
2916:
2914:
2913:
2907:
2900:
2897:
2894:
2893:
2888:
2887:
2880:
2873:
2865:
2845:
2844:
2801:
2781:(2): 269–276.
2766:
2731:
2696:
2661:
2621:(6): 305–308.
2610:
2575:
2557:(4): 977–981.
2546:
2493:
2473:(2): 497–500.
2458:
2432:(3): 345–348.
2420:
2385:
2348:
2322:(4): 325–329.
2311:
2282:
2264:(6): 958–961.
2253:
2209:
2207:
2204:
2201:
2200:
2149:
2118:(1): 135–146.
2098:
2044:
2003:
1952:
1917:
1903:
1852:
1803:
1788:
1752:
1693:
1664:(1): 485–506.
1644:
1600:
1553:
1532:(5): 337–343.
1512:
1493:(2): 494–498.
1477:
1459:
1441:
1420:
1398:
1397:
1395:
1392:
1386:
1383:
1326:, such as the
1304:
1301:
1275:
1272:
1239:
1236:
1206:
1203:
1176:in plasma and
1153:
1152:
1149:
1148:
1143:
1133:
1132:
1126:
1125:
1122:
1121:
1119:
1117:
1110:
1109:
1102:
1095:
1091:
1090:
1087:
1086:
1076:
1075:
1069:
1066:
1065:
1055:
1054:
1048:
1044:
1043:
1040:
1039:
1029:
1028:
1022:
1019:
1018:
1008:
1007:
1001:
997:
996:
993:
992:
984:
983:
977:
974:
973:
965:
964:
958:
952:
951:
948:
947:
939:
938:
932:
929:
928:
920:
919:
913:
907:
906:
903:
902:
894:
893:
887:
884:
883:
875:
874:
868:
862:
861:
856:
851:
847:
846:
836:
835:
832:
831:
820:
819:
817:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
670:
668:
664:
663:
661:
660:
655:
650:
645:
639:
637:
633:
632:
630:
629:
624:
619:
614:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
6383:
6372:
6369:
6367:
6364:
6363:
6361:
6345:
6342:
6339:
6338:
6335:
6332:
6329:
6325:
6322:
6320:
6317:
6315:
6312:
6310:
6307:
6305:
6302:
6300:
6297:
6295:
6292:
6290:
6287:
6285:
6282:
6279:
6275:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6250:
6246:
6243:
6240:
6236:
6232:
6228:
6224:
6220:
6216:
6212:
6208:
6205:
6203:
6200:
6197:
6193:
6190:
6188:
6185:
6182:
6181:
6179:
6175:
6169:
6166:
6163:
6162:
6159:
6156:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6136:
6133:
6132:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6091:
6089:
6086:
6084:
6081:
6079:
6076:
6074:
6071:
6069:
6066:
6064:
6061:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6031:
6029:
6026:
6023:
6022:
6019:
6018:Cyclotraxin B
6016:
6013:
6012:
6008:
6004:
6000:
5996:
5992:
5989:
5987:
5984:
5982:
5979:
5977:
5974:
5971:
5970:
5968:
5966:
5962:
5952:
5949:
5947:
5944:
5942:
5939:
5937:
5934:
5932:
5931:Larotrectinib
5929:
5927:
5924:
5922:
5919:
5917:
5914:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5886:
5885:
5882:
5879:
5877:
5874:
5872:
5869:
5866:
5865:
5863:
5861:
5857:
5851:
5848:
5846:
5843:
5841:
5838:
5836:
5833:
5831:
5830:Larotrectinib
5828:
5826:
5823:
5821:
5818:
5816:
5813:
5811:
5808:
5806:
5803:
5801:
5798:
5796:
5793:
5791:
5788:
5785:
5784:
5781:
5778:
5775:
5774:
5771:
5768:
5766:
5765:Cyclotraxin B
5763:
5761:
5758:
5755:
5754:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5721:
5718:
5716:
5713:
5711:
5708:
5706:
5703:
5701:
5698:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5675:Amitriptyline
5673:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5646:
5643:
5641:
5638:
5635:
5634:
5632:
5630:
5626:
5620:
5617:
5614:
5613:
5610:
5607:
5604:
5601:
5600:
5597:
5594:
5592:
5589:
5587:
5584:
5582:
5579:
5577:
5574:
5572:
5569:
5567:
5564:
5562:
5559:
5555:
5552:
5551:Against TrkA:
5549:
5546:
5545:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5508:
5506:
5505:Larotrectinib
5503:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5460:
5459:
5456:
5453:
5450:
5449:
5446:
5443:
5441:
5438:
5436:
5435:Dexamethasone
5433:
5431:
5428:
5425:
5424:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5380:Amitriptyline
5378:
5375:
5374:
5372:
5370:
5366:
5363:
5361:
5357:
5350:
5346:
5345:
5343:
5341:
5337:
5331:
5328:
5326:
5323:
5321:
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5288:
5286:
5283:
5281:
5278:
5275:
5274:
5271:
5268:
5266:
5263:
5260:
5259:
5257:
5255:
5251:
5241:
5238:
5235:
5234:
5232:
5228:
5222:
5219:
5216:
5215:
5212:
5209:
5206:
5205:
5203:
5201:
5197:
5191:
5188:
5185:
5184:
5181:
5178:
5175:
5174:
5172:
5170:
5166:
5160:
5157:
5154:
5153:
5150:
5147:
5144:
5143:
5141:
5139:
5135:
5129:
5126:
5123:
5122:
5119:
5116:
5114:
5111:
5108:
5107:
5105:
5103:
5099:
5096:
5094:
5090:
5084:
5081:
5079:
5076:
5074:
5071:
5068:
5067:
5064:
5061:
5059:
5056:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4983:
4982:
4978:
4974:
4970:
4966:
4962:
4959:
4957:
4954:
4951:
4950:
4948:
4946:
4942:
4936:
4933:
4930:
4929:
4926:
4923:
4920:
4917:
4916:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4872:
4869:
4868:
4865:
4862:
4860:
4857:
4855:
4854:Dexamethasone
4852:
4850:
4847:
4844:
4843:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4794:
4793:
4791:
4789:
4785:
4775:
4772:
4770:
4767:
4764:
4763:
4759:
4755:
4751:
4747:
4743:
4739:
4735:
4731:
4728:
4725:
4724:
4722:
4718:
4711:
4708:
4706:
4703:
4700:
4699:
4696:
4692:
4689:
4688:
4686:
4684:
4680:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4627:
4626:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4597:
4596:
4593:
4590:
4588:
4585:
4583:
4580:
4578:
4575:
4573:
4570:
4568:
4565:
4563:
4562:des(1-3)IGF-1
4559:
4556:
4555:
4553:
4551:
4547:
4544:
4542:
4538:
4532:
4529:
4527:
4526:Telisotuzumab
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4496:
4495:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4391:
4390:
4387:
4384:
4383:Potentiators:
4381:
4380:
4377:
4374:
4372:
4368:
4365:
4364:
4362:
4360:
4356:
4346:
4343:
4340:
4339:
4337:
4333:
4327:
4324:
4321:
4317:
4313:
4309:
4305:
4301:
4297:
4293:
4290:
4288:
4285:
4282:
4281:
4279:
4277:
4273:
4266:
4263:
4260:
4259:
4256:
4253:
4251:
4248:
4246:
4245:Selpercatinib
4243:
4240:
4236:
4232:
4228:
4224:
4220:
4216:
4212:
4209:
4207:
4204:
4201:
4200:
4198:
4196:
4192:
4186:
4183:
4180:
4179:
4176:
4173:
4171:
4168:
4165:
4164:
4161:
4158:
4156:
4153:
4151:
4150:Selpercatinib
4148:
4146:
4143:
4141:
4138:
4135:
4131:
4127:
4123:
4119:
4115:
4111:
4107:
4103:
4099:
4095:
4091:
4087:
4083:
4079:
4076:
4074:
4071:
4068:
4067:
4065:
4063:
4059:
4053:
4050:
4048:
4045:
4043:
4042:Selpercatinib
4040:
4038:
4035:
4032:
4028:
4024:
4020:
4016:
4012:
4008:
4004:
4000:
3996:
3993:
3991:
3988:
3985:
3984:
3982:
3980:
3976:
3973:
3971:
3967:
3956:
3952:
3948:
3944:
3940:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3915:
3914:
3912:
3910:
3906:
3900:
3897:
3895:
3892:
3890:
3887:
3884:
3883:
3879:
3875:
3871:
3867:
3864:
3861:
3860:
3858:
3856:
3852:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3820:
3819:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3785:
3784:
3781:
3777:
3774:
3773:
3771:
3769:
3765:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3718:Depatuxizumab
3716:
3714:
3711:
3708:
3707:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3633:
3632:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3585:
3582:
3581:
3579:
3577:
3569:
3566:
3564:
3560:
3554:
3551:
3549:
3546:
3544:
3541:
3538:
3537:
3535:
3533:
3529:
3522:
3519:
3516:
3513:
3510:
3509:
3506:
3503:
3501:
3498:
3496:
3493:
3490:
3489:
3486:
3483:
3481:
3478:
3475:
3474:
3471:
3468:
3466:
3463:
3460:
3459:
3457:
3455:
3451:
3447:
3444:
3437:
3432:
3430:
3425:
3423:
3418:
3417:
3414:
3402:
3399:
3397:
3394:
3393:
3391:
3387:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3357:
3355:
3353:
3349:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3324:
3322:
3320:
3316:
3304:
3301:
3299:
3296:
3294:
3291:
3290:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3265:
3263:
3260:
3259:
3253:
3247:
3244:
3242:
3239:
3238:
3236:
3233:
3232:
3228:
3222:
3219:
3217:
3211:
3203:
3200:
3198:
3195:
3193:
3190:
3189:
3188:
3185:
3184:
3182:
3180:
3176:
3170:
3167:
3165:
3162:
3160:
3157:
3156:
3154:
3152:
3148:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3119:
3117:
3114:
3111:
3110:hormone-like:
3106:
3099:
3096:
3093:
3090:
3087:
3084:
3081:
3078:
3077:
3075:
3072:
3067:
3061:
3057:
3053:
3050:
3048:
3044:
3040:
3037:
3035:
3031:
3027:
3024:
3023:
3021:
3018:
3017:
3011:
3005:
3001:
2997:
2994:
2992:
2988:
2984:
2981:
2980:
2978:
2975:
2973:
2967:
2964:
2962:
2958:
2954:
2947:
2942:
2940:
2935:
2933:
2928:
2927:
2924:
2910:
2904:
2899:
2898:
2895:
2886:
2881:
2879:
2874:
2872:
2867:
2866:
2863:
2859:
2858:
2856:
2855:public domain
2852:
2841:
2837:
2832:
2827:
2823:
2819:
2815:
2811:
2807:
2802:
2798:
2794:
2789:
2784:
2780:
2776:
2772:
2767:
2763:
2759:
2754:
2749:
2745:
2741:
2737:
2732:
2728:
2724:
2719:
2714:
2710:
2706:
2702:
2697:
2693:
2689:
2684:
2679:
2675:
2671:
2667:
2662:
2658:
2652:
2644:
2640:
2636:
2632:
2628:
2624:
2620:
2616:
2611:
2607:
2603:
2598:
2593:
2589:
2585:
2581:
2576:
2572:
2568:
2564:
2560:
2556:
2552:
2547:
2543:
2539:
2534:
2529:
2524:
2519:
2515:
2511:
2507:
2503:
2499:
2494:
2490:
2486:
2481:
2476:
2472:
2468:
2464:
2459:
2455:
2451:
2447:
2443:
2439:
2438:10.1038/81664
2435:
2431:
2427:
2421:
2417:
2413:
2408:
2403:
2399:
2395:
2391:
2386:
2382:
2378:
2374:
2370:
2366:
2362:
2358:
2354:
2349:
2345:
2341:
2337:
2333:
2329:
2325:
2321:
2317:
2312:
2308:
2304:
2300:
2296:
2292:
2288:
2283:
2279:
2275:
2271:
2267:
2263:
2259:
2254:
2250:
2246:
2241:
2236:
2232:
2228:
2224:
2220:
2216:
2211:
2210:
2196:
2192:
2187:
2182:
2177:
2172:
2168:
2164:
2160:
2153:
2145:
2141:
2136:
2131:
2126:
2121:
2117:
2113:
2109:
2102:
2094:
2090:
2085:
2080:
2075:
2070:
2066:
2062:
2058:
2051:
2049:
2040:
2036:
2031:
2026:
2022:
2018:
2014:
2007:
1999:
1995:
1990:
1985:
1980:
1975:
1971:
1967:
1963:
1956:
1948:
1944:
1940:
1936:
1932:
1928:
1927:Oral Oncology
1921:
1913:
1907:
1899:
1895:
1890:
1885:
1880:
1875:
1871:
1867:
1866:F1000Research
1863:
1856:
1848:
1844:
1839:
1834:
1830:
1826:
1822:
1818:
1814:
1807:
1799:
1795:
1791:
1785:
1780:
1775:
1771:
1767:
1763:
1756:
1748:
1744:
1739:
1734:
1729:
1724:
1720:
1716:
1712:
1708:
1704:
1697:
1689:
1685:
1680:
1675:
1671:
1667:
1663:
1659:
1655:
1648:
1633:
1629:
1624:
1619:
1615:
1611:
1604:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1560:
1558:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1516:
1508:
1504:
1500:
1496:
1492:
1488:
1481:
1473:
1469:
1463:
1455:
1451:
1445:
1438:
1434:
1429:
1427:
1425:
1417:
1413:
1408:
1406:
1404:
1399:
1391:
1382:
1380:
1376:
1371:
1369:
1364:
1361:
1359:
1355:
1351:
1346:
1344:
1340:
1336:
1332:
1329:
1325:
1320:
1318:
1314:
1310:
1307:Mutations in
1300:
1298:
1294:
1290:
1289:chromosome 12
1286:
1283:
1282:
1271:
1269:
1265:
1260:
1258:
1254:
1250:
1246:
1235:
1233:
1229:
1225:
1221:
1218:
1217:
1212:
1202:
1200:
1196:
1192:
1189:
1188:
1183:
1179:
1175:
1171:
1167:
1163:
1159:
1147:
1142:
1138:
1134:
1131:
1127:
1120:
1118:
1115:
1111:
1107:
1103:
1100:
1096:
1092:
1085:
1083:
1077:
1073:
1070:
1064:
1062:
1056:
1052:
1049:
1045:
1038:
1036:
1030:
1026:
1023:
1017:
1015:
1009:
1005:
1002:
1000:RefSeq (mRNA)
998:
991:
990:
985:
981:
978:
972:
971:
966:
962:
959:
957:
953:
946:
945:
940:
936:
933:
927:
926:
921:
917:
914:
912:
908:
901:
900:
895:
891:
888:
882:
881:
876:
872:
869:
867:
863:
860:
857:
855:
852:
848:
845:
841:
837:
830:
826:
821:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
671:
669:
666:
665:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
481:
478:
474:
469:
466:
456:
452:
449:muscle tissue
448:
444:
440:
436:
433:right auricle
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
6344:Cerebrolysin
6340:
6314:Pleiotrophin
6270:Interleukins
6183:
6164:
6134:
6053:Fruquintinib
6043:Cabozantinib
6024:
6014:
5972:
5936:Lestaurtinib
5887:
5867:
5835:Lestaurtinib
5786:
5776:
5757:Antagonists:
5756:
5690:Deoxygedunin
5645:3,7,8,2'-THF
5636:
5615:
5606:Against NGF:
5605:
5602:
5558:Against NGF:
5557:
5550:
5547:
5510:Lestaurtinib
5461:
5451:
5445:Testosterone
5427:Antagonists:
5426:
5376:
5276:
5261:
5236:
5217:
5207:
5186:
5176:
5155:
5145:
5124:
5109:
5069:
4984:
4952:
4931:
4922:Against NGF:
4921:
4918:
4874:Against NGF:
4873:
4870:
4864:Testosterone
4846:Antagonists:
4845:
4795:
4765:
4726:
4701:
4690:
4667:Teprotumumab
4628:
4598:
4557:
4506:Ficlatuzumab
4501:Emibetuzumab
4497:
4451:JNJ-38877605
4421:Cabozantinib
4392:
4382:
4371:Fosgonimeton
4366:
4341:
4283:
4261:
4202:
4185:Infigratinib
4181:
4166:
4069:
3986:
3920:Betacellulin
3916:
3899:Seribantumab
3885:
3862:
3821:
3786:
3780:Unknown/none
3779:
3775:
3709:
3634:
3593:Betacellulin
3588:Amphiregulin
3583:
3575:(ErbB1/HER1)
3539:
3511:
3491:
3477:Antagonists:
3476:
3461:
3454:Angiopoietin
3256:
3225:
3214:Insulin/IGF/
3179:TGFβ pathway
3136:
3109:
3070:
3014:
2972:FGF receptor
2970:
2908:
2848:
2847:
2813:
2809:
2778:
2774:
2743:
2739:
2708:
2704:
2673:
2669:
2651:cite journal
2618:
2614:
2587:
2583:
2554:
2550:
2505:
2501:
2470:
2466:
2429:
2425:
2397:
2393:
2356:
2352:
2319:
2315:
2293:(1): E1–E9.
2290:
2286:
2261:
2257:
2222:
2218:
2166:
2162:
2152:
2115:
2111:
2101:
2064:
2060:
2020:
2016:
2006:
1969:
1966:Bone Reports
1965:
1955:
1933:(2): e9-10.
1930:
1926:
1920:
1906:
1869:
1865:
1855:
1820:
1816:
1806:
1761:
1755:
1710:
1706:
1696:
1661:
1657:
1647:
1635:. Retrieved
1613:
1603:
1570:
1566:
1529:
1525:
1515:
1490:
1486:
1480:
1471:
1462:
1453:
1444:
1388:
1372:
1365:
1362:
1347:
1321:
1308:
1306:
1279:
1277:
1261:
1241:
1214:
1208:
1194:
1185:
1161:
1157:
1156:
1079:
1058:
1032:
1011:
987:
968:
942:
923:
897:
878:
858:
853:
799:MAPK cascade
515:carotid body
395:
388:
354:127,058,371
341:127,049,865
115:External IDs
74:
18:
6304:Oncomodulin
6168:Aflibercept
6158:Ranibizumab
6153:Ramucirumab
6143:Bevacizumab
6135:Antibodies:
6093:Regorafenib
6033:Altiratinib
5946:ONO-5390556
5916:Entrectinib
5891:Altiratinib
5845:ONO-5390556
5815:Entrectinib
5790:Altiratinib
5576:Frunevetmab
5548:Antibodies:
5525:ONO-5390556
5490:Entrectinib
5465:Altiratinib
5420:Tavilermide
5315:Quizartinib
5254:SCF (c-Kit)
5078:Ramucirumab
5070:Antibodies:
5043:Quizartinib
4993:Avapritinib
4956:Becaplermin
4892:Frunevetmab
4871:Antibodies:
4774:Trofinetide
4705:Dusigitumab
4702:Antibodies:
4657:Robatumumab
4647:Figitumumab
4642:Dalotuzumab
4637:Cixutumumab
4629:Antibodies:
4521:Rilotumumab
4516:Onartuzumab
4511:Flanvotumab
4498:Antibodies:
4466:PF-04217903
4396:Altiratinib
4359:HGF (c-Met)
4262:Antibodies:
4167:Antibodies:
3889:Duligotumab
3886:Antibodies:
3800:Trastuzumab
3790:Ertumaxomab
3787:Antibodies:
3758:Zalutumumab
3753:Panitumumab
3748:Nimotuzumab
3743:Necitumumab
3733:Imgatuzumab
3710:Antibodies:
3693:Osimertinib
3658:Dacomitinib
3553:Dapiclermin
3512:Antibodies:
3495:Altiratinib
2891:PDB gallery
2225:(1): 7–14.
1779:10012/15679
1331:mesenchymal
1205:Description
648:Golgi lumen
421:sural nerve
333:6|6 F3
93:Identifiers
6360:Categories
6123:Vandetanib
6088:Rebastinib
6083:Pegaptanib
6073:Nintedanib
6063:Lenvatinib
6028:Agerafenib
5981:Ripretinib
5906:CH-7057288
5805:CH-7057288
5670:7,8,3'-THF
5665:7,8,2'-THF
5591:Ranevetmab
5581:Fulranumab
5535:Rebastinib
5480:CH-7057288
5395:Cenegermin
5280:Agerafenib
5240:Agerafenib
5221:Vandetanib
5190:Vandetanib
5159:Vandetanib
5128:Vandetanib
5073:Olaratumab
5048:Ripretinib
5028:Nintedanib
5013:Lenvatinib
5003:Crenolanib
4988:Agerafenib
4907:Ranevetmab
4897:Fulranumab
4814:Cenegermin
4788:LNGF (p75)
4710:Xentuzumab
4672:Xentuzumab
4617:NVP-AEW541
4612:NVP-ADW742
4607:Linsitinib
4602:BMS-754807
4587:Mecasermin
4486:Tivantinib
4476:PHA-665752
4471:PF-2341066
4441:Golvatinib
4431:Crizotinib
4426:Capmatinib
4416:BMS-777607
4411:Amuvatinib
4287:Ersofermin
4250:Sprifermin
4206:Ersofermin
4155:Sprifermin
4145:Repifermin
4140:Palifermin
4073:Ersofermin
4052:Velafermin
4037:Repifermin
3990:Ersofermin
3909:ErbB4/HER4
3894:Patritumab
3855:ErbB3/HER3
3835:Mubritinib
3795:Pertuzumab
3768:ErbB2/HER2
3698:Vandetanib
3653:Canertinib
3648:Brigatinib
3643:Agerafenib
3623:Nepidermin
3618:Murodermin
3608:Epiregulin
3563:EGF (ErbB)
3521:Nesvacumab
3515:Evinacumab
3505:Rebastinib
3446:modulators
3401:Hepatocyte
2961:Fibroblast
1439:, May 2017
1418:, May 2017
1394:References
1350:calcinosis
1249:calcitriol
1245:osteocytes
399:(ortholog)
253:4,379,712
240:4,368,227
136:HomoloGene
6148:Icrucumab
6128:WHI-P 154
6118:Tivozanib
6113:Toceranib
6108:Sunitinib
6103:Sorafenib
6098:Semaxanib
6078:Pazopanib
6068:Motesanib
6058:Lapatinib
6048:Cediranib
5986:Telbermin
5973:Agonists:
5921:GZ-389988
5901:CE-245677
5868:Agonists:
5820:GZ-389988
5800:CE-245677
5700:Diosmetin
5637:Agonists:
5603:Aptamers:
5596:Tanezumab
5571:Fasinumab
5515:Milciclib
5495:GZ-389988
5475:CE-245677
5377:Agonists:
5330:Toceranib
5325:Sunitinib
5320:Sorafenib
5310:Pazopanib
5305:Nilotinib
5300:Masitinib
5290:Dasatinib
5262:Agonists:
5208:Agonists:
5177:Agonists:
5146:Agonists:
5118:Liatermin
5110:Agonists:
5093:RET (GFL)
5083:Tovetumab
5063:Toceranib
5058:Sorafenib
5053:Sunitinib
5038:Radotinib
5033:Pazopanib
5023:Motesanib
5018:Masitinib
4953:Agonists:
4919:Aptamers:
4912:Tanezumab
4887:Fasinumab
4796:Agonists:
4652:Ganitumab
4572:IGF-1 LR3
4491:Volitinib
4446:INCB28060
4436:Foretinib
4342:Agonists:
4326:Trafermin
4284:Agonists:
4265:Burosumab
4255:Trafermin
4203:Agonists:
4170:Aprutumab
4160:Trafermin
4122:10 (KGF2)
4070:Agonists:
4047:Trafermin
4027:10 (KGF2)
3987:Agonists:
3917:Agonists:
3863:Agonists:
3845:Tucatinib
3840:Neratinib
3830:Lapatinib
3738:Matuzumab
3728:Futuximab
3713:Cetuximab
3703:WHI-P 154
3688:Neratinib
3683:Lapatinib
3673:Grandinin
3668:Gefitinib
3663:Erlotinib
3540:Agonists:
3500:CE-245677
3462:Agonists:
2067:(1): 58.
1972:: 63–69.
1798:102827267
1632:247095495
1333:neoplasm
1268:vitamin D
1232:vitamin D
1228:phosphate
1178:vitamin D
1174:phosphate
1082:NP_073148
1061:NP_065689
1035:NM_022657
1014:NM_020638
844:Orthologs
144:GeneCards
6330:instead)
6319:Renalase
6280:instead)
6251:instead)
6198:instead)
6038:Axitinib
6007:D (FIGF)
5951:PLX-7486
5941:ONO-4474
5896:AZD-6918
5850:PLX-7486
5840:ONO-4474
5795:AZD-6918
5777:Ligands:
5695:Deprenyl
5655:7,3'-DHF
5586:MEDI-578
5566:ASP-6294
5530:PLX-7486
5520:ONO-4474
5470:AZD-6918
5430:ALE-0540
5351:instead.
5295:Imatinib
5285:Axitinib
5265:Ancestim
5230:Unsorted
5008:Imatinib
4998:Axitinib
4902:MEDI-578
4882:ASP-6294
4849:ALE-0540
4691:Agonists
4632:AVE-1642
4558:Agonists
4481:SU-11274
4367:Agonists
4345:FGF15/19
4335:Unsorted
4300:2 (bFGF)
4219:2 (bFGF)
4086:2 (bFGF)
4003:2 (bFGF)
3825:Afatinib
3776:Agonists
3678:Icotinib
3638:Afatinib
3584:Agonists
3113:FGF15/19
2974:ligands:
2840:12678920
2797:12590648
2762:12519781
2727:12419819
2692:12032146
2643:46748089
2635:11805436
2606:11737582
2571:11409890
2542:11344269
2489:11157998
2454:38870810
2446:11062477
2416:17494882
2373:16033853
2344:23555353
2336:15930999
2307:12791601
2278:12032180
2249:19029978
2195:11371627
2144:26535997
2093:30808384
2039:20375979
1998:28932769
1947:21985764
1898:27081473
1872:: 1472.
1847:21346724
1747:18606998
1688:32040934
1595:20559055
1587:17699549
1548:18310961
1507:11032749
1435:–
1414:–
1337:causing
1274:Genetics
1238:Function
1130:Wikidata
823:Sources:
429:testicle
232:12p13.32
6207:Ephrins
5911:DS-6051
5810:DS-6051
5715:LM22A-4
5705:DMAQ-B1
5660:7,8-DHF
5640:3,7-DHF
5609:RBM-004
5554:GBR-900
5485:DS-6051
5455:VM-902A
4925:RBM-004
4622:OSl-906
4582:Insulin
4461:MK-2461
4406:AMG-458
3543:Axokine
3288:Relaxin
3227:Insulin
2831:1223479
2510:Bibcode
2381:8612881
2240:4292907
2135:4854810
2084:6390548
1989:5596358
1889:4815615
1838:3257051
1738:2474477
1715:Bibcode
1679:8274561
1637:8 March
1437:Ensembl
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1166:protein
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956:UniProt
911:Ensembl
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829:QuickGO
374:pattern
132:1891427
100:Aliases
6177:Others
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5760:ANA-12
5685:BNN-20
5405:DHEA-S
5390:BNN-27
5385:BNN-20
4824:DHEA-S
4809:BNN-27
4804:BNN-20
4720:Others
3925:Epigen
3603:Epigen
3375:VEGF-D
3370:VEGF-C
3365:VEGF-B
3360:VEGF-A
3169:HB-EGF
3100:(FHF4)
3094:(FHF2)
3088:(FHF1)
3082:(FHF3)
2838:
2828:
2795:
2760:
2725:
2690:
2641:
2633:
2604:
2569:
2540:
2530:
2487:
2452:
2444:
2414:
2379:
2371:
2342:
2334:
2305:
2276:
2247:
2237:
2193:
2183:
2142:
2132:
2091:
2081:
2037:
1996:
1986:
1945:
1896:
1886:
1845:
1835:
1796:
1786:
1745:
1735:
1686:
1676:
1630:
1593:
1585:
1546:
1505:
1354:klotho
1328:benign
1324:tumors
1162:FGF-23
1116:search
1114:PubMed
989:Q9EPC2
970:Q9GZV9
866:Entrez
545:BioGPS
491:zygote
483:embryo
124:605380
6326:(see
6276:(see
6247:(see
6194:(see
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5825:K252a
5500:K252a
5440:FX007
5200:GFRα4
5169:GFRα3
5138:GFRα2
5102:GFRα1
4730:IGFBP
4683:IGF-2
4662:R1507
4550:IGF-1
4456:K252a
4276:FGFR4
4195:FGFR3
4062:FGFR2
3979:FGFR1
3396:Nerve
3389:Other
3342:PDGFD
3337:PDGFC
3332:PDGFB
3327:PDGFA
3283:INSL6
3278:INSL5
3273:INSL4
3268:INSL3
3202:TGFβ3
3197:TGFβ2
3192:TGFβ1
3137:FGF23
3132:FGF21
3127:FGF19
3122:FGF15
3098:FGF14
3092:FGF13
3086:FGF12
3080:FGF11
3060:FGF20
3056:FGF16
3047:FGF18
3043:FGF17
3034:FGF22
3030:FGF10
2639:S2CID
2533:33497
2450:S2CID
2377:S2CID
2340:S2CID
2186:33399
1794:S2CID
1628:S2CID
1591:S2CID
1313:renal
1309:FGF23
1293:exons
1281:FGF23
1216:FGF23
1195:FGF23
1187:FGF23
899:64654
859:Mouse
854:Human
825:Amigo
457:blood
437:liver
425:gonad
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
148:FGF23
140:10771
107:FGF23
24:FGF23
6328:here
6278:here
6249:here
6196:here
5991:VEGF
5965:VEGF
5881:NT-3
5876:DHEA
5860:TrkC
5780:DHEA
5750:TDP6
5730:NT-4
5725:NT-3
5710:HIOC
5680:BDNF
5629:TrkB
5400:DHEA
5369:TrkA
5349:here
5347:See
5340:TGFβ
4945:PDGF
4839:NT-4
4834:NT-3
4819:DHEA
4799:BDNF
3548:CNTF
3532:CNTF
3246:IGF2
3241:IGF1
3229:and
3187:TGFβ
3159:TGFα
3052:FGF9
3039:FGF8
3026:FGF7
3004:FGF6
3000:FGF4
2996:FGF3
2991:FGF5
2987:FGF2
2983:FGF1
2909:2p39
2836:PMID
2793:PMID
2758:PMID
2723:PMID
2688:PMID
2657:link
2631:PMID
2602:PMID
2567:PMID
2538:PMID
2485:PMID
2442:PMID
2412:PMID
2369:PMID
2332:PMID
2303:PMID
2274:PMID
2245:PMID
2191:PMID
2140:PMID
2089:PMID
2035:PMID
1994:PMID
1943:PMID
1894:PMID
1843:PMID
1784:ISBN
1743:PMID
1684:PMID
1639:2022
1583:PMID
1544:PMID
1503:PMID
1341:, a
1285:gene
1230:and
1220:gene
1191:gene
880:8074
380:Bgee
328:Band
289:Chr.
227:Band
186:Chr.
120:OMIM
77:2P39
58:RCSB
55:PDBe
5745:R13
5415:NGF
5360:Trk
4829:NGF
4541:IGF
4401:AM7
4292:FGF
4211:FGF
4112:),
4110:KGF
4078:FGF
3995:FGF
3970:FGF
3572:EGF
3380:PGF
3164:EGF
3016:KGF
2826:PMC
2818:doi
2814:373
2783:doi
2779:148
2748:doi
2744:278
2713:doi
2709:278
2678:doi
2674:277
2623:doi
2592:doi
2559:doi
2555:284
2528:PMC
2518:doi
2475:doi
2434:doi
2402:doi
2361:doi
2324:doi
2295:doi
2291:285
2266:doi
2235:PMC
2227:doi
2181:PMC
2171:doi
2130:PMC
2120:doi
2079:PMC
2069:doi
2025:doi
1984:PMC
1974:doi
1935:doi
1884:PMC
1874:doi
1833:PMC
1825:doi
1774:hdl
1766:doi
1733:PMC
1723:doi
1711:105
1674:PMC
1666:doi
1618:doi
1575:doi
1571:293
1534:doi
1495:doi
1491:277
350:End
249:End
152:OMA
128:MGI
48:PDB
6362::
6239:B3
6237:,
6235:B2
6233:,
6231:B1
6229:,
6227:A5
6225:,
6223:A4
6221:,
6219:A3
6217:,
6215:A2
6213:,
6211:A1
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5740:R7
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