Knowledge

File:Considerations for the design of engineered live bacterial therapeutics.pdf

Source 📝

43: 483:"}},"text\/plain":{"en":{"":"checksum"}}},"{\"value\":\"78cd57837d6817c3c2e096e17b0c5032757ae5d5\",\"type\":\"string\"}":{"text\/html":{"en":{"P4092":"78cd57837d6817c3c2e096e17b0c5032757ae5d5"}},"text\/plain":{"en":{"P4092":"78cd57837d6817c3c2e096e17b0c5032757ae5d5"}}},"{\"value\":{\"entity-type\":\"property\",\"numeric-id\":459,\"id\":\"P459\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"":" 407:"}},"text\/plain":{"en":{"":"inception"}}},"{\"value\":{\"time\":\"+2020-04-08T00:00:00Z\",\"timezone\":0,\"before\":0,\"after\":0,\"precision\":11,\"calendarmodel\":\"http:\\\/\\\/www.wikidata.org\\\/entity\\\/Q1985727\"},\"type\":\"time\"}":{"text\/html":{"en":{"P571":"8 April 2020"}},"text\/plain":{"en":{"P571":"8 April 2020"}}}}": --> 190: 479: 146:
also be influenced by the circuit’s effectors, pragmatic concerns regarding inducer compounds, and the genetic stability of regulatory circuits. Critically, the design of an engineered bacterial drug may also be constrained by considerations for the needs of patients. b Optimal strain design often requires a balance between strain suitability for function in the target microenvironment and concerns for feasibility of manufacturing and clinical development.
91: 761: 685:"}},"text\/plain":{"en":{"":"number of pages"}}},"{\"value\":{\"amount\":\"+1\",\"unit\":\"1\"},\"type\":\"quantity\"}":{"text\/html":{"en":{"P1104":"1"}},"text\/plain":{"en":{"P1104":"1"}}}}": --> 445:"}},"text\/plain":{"en":{"":"media type"}}},"{\"value\":\"application\\\/pdf\",\"type\":\"string\"}":{"text\/html":{"en":{"P1163":"application\/pdf"}},"text\/plain":{"en":{"P1163":"application\/pdf"}}}}": --> 487:"}},"text\/plain":{"en":{"":"determination method"}}},"{\"value\":{\"entity-type\":\"item\",\"numeric-id\":13414952,\"id\":\"Q13414952\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"P459":" 363:"}},"text\/plain":{"en":{"":"copyright license"}}},"{\"value\":{\"entity-type\":\"item\",\"numeric-id\":20007257,\"id\":\"Q20007257\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"P275":" 319:"}},"text\/plain":{"en":{"":"copyright status"}}},"{\"value\":{\"entity-type\":\"item\",\"numeric-id\":50423863,\"id\":\"Q50423863\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"P6216":" 550:"}},"text\/plain":{"en":{"":"data size"}}},"{\"value\":{\"amount\":\"+403562\",\"unit\":\"http:\\\/\\\/www.wikidata.org\\\/entity\\\/Q8799\"},\"type\":\"quantity\"}":{"text\/html":{"en":{"P3575":"403,562 595:"}},"text\/plain":{"en":{"":"height"}}},"{\"value\":{\"amount\":\"+1200\",\"unit\":\"http:\\\/\\\/www.wikidata.org\\\/entity\\\/Q355198\"},\"type\":\"quantity\"}":{"text\/html":{"en":{"P2048":"1,200 640:"}},"text\/plain":{"en":{"":"width"}}},"{\"value\":{\"amount\":\"+750\",\"unit\":\"http:\\\/\\\/www.wikidata.org\\\/entity\\\/Q355198\"},\"type\":\"quantity\"}":{"text\/html":{"en":{"P2049":"750 681: 57: 53: 47: 102: 70: 237:– You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. 868: 488: 364: 320: 682: 637: 592: 547: 480: 442: 316: 484: 404: 360: 778:
Uploaded a work by Mark R. Charbonneau, Vincent M. Isabella, Ning Li & Caroline B. Kurtz from https://doi.org/10.1038/s41467-020-15508-1 with UploadWizard
268: 760: 755: 42: 367:"}},"text\/plain":{"en":{"P275":"Creative Commons Attribution 4.0 International"}}}}": --> 815: 532: 390: 346: 848:
This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
692: 651: 606: 561: 498: 452: 330: 825: 525: 414: 374: 305: 851:
If the file has been modified from its original state, some details may not fully reflect the modified file.
206: 554:"}},"text\/plain":{"en":{"P3575":"403,562 byte"}}}}": --> 599:"}},"text\/plain":{"en":{"P2048":"1,200 pixel"}}}}": --> 323:"}},"text\/plain":{"en":{"P6216":"copyrighted"}}}}": --> 644:"}},"text\/plain":{"en":{"P2049":"750 pixel"}}}}": --> 110: 491:"}},"text\/plain":{"en":{"P459":"SHA-1"}}}}": --> 203: 8: 792: 97: 295: 797: 771: 165: 860:
Considerations for the design of engineered live bacterial therapeutics.pdf
135:
Considerations for the design of engineered live bacterial therapeutics.pdf
702: 661: 616: 571: 508: 462: 424: 384: 340: 175:
Mark R. Charbonneau, Vincent M. Isabella, Ning Li & Caroline B. Kurtz
289:
Considerations for the design of engineered live bacterial therapeutics
728:
Click on a date/time to view the file as it appeared at that time.
155: 85: 835: 786: 806: 726: 109:
Commons is a freely licensed media file repository.
75:(750 × 1,200 pixels, file size: 394 KB, MIME type: 391:Creative Commons Attribution 4.0 International 365:Creative Commons Attribution 4.0 International 90: 189: 151: 132: 171: 161: 14: 641: 596: 551: 244:https://creativecommons.org/licenses/by/4.0 220:– to copy, distribute and transmit the work 46:Size of this JPG preview of this PDF file: 166:https://doi.org/10.1038/s41467-020-15508-1 808:The following other wikis use this file: 514:78cd57837d6817c3c2e096e17b0c5032757ae5d5 869:Serif Affinity Designer (Mar 31 2020) 788:The following 2 pages use this file: 121: 719: 195: 13: 846: 294: 288: 211: 186: 139: 122: 68: 914: 878:PDFlib+PDI 9.1.2p1-i (OS X/macOS) 853: 293: 250:Creative Commons Attribution 4.0 279: 231:Under the following conditions: 202:This file is licensed under the 194: 188: 89: 31: 21: 276: 263: 140: 803: 723: 275: 261: 26: 1: 207:Attribution 4.0 International 36: 783: 301:Items portrayed in this file 182: 7: 843: 10: 919: 832:Usage on www.wikidata.org 822:Usage on fa.wikipedia.org 812:Usage on ar.wikipedia.org 129: 124: 720: 16: 278: 96:This is a file from the 41: 777: 154: 100:. Information from its 103:description page there 899:Version of PDF format 526:determination method 485:determination method 756:17:45, 8 April 2020 226:– to adapt the work 52:Other resolutions: 875:Conversion program 269:Template:CC-notice 62:750 × 1,200 pixels 906: 905: 804:Global file usage 793:Bacterial therapy 781: 643: 598: 553: 375:copyright license 361:copyright license 287: 179: 178: 118: 117: 98:Wikimedia Commons 32:Global file usage 910: 854: 768: 730: 670: 625: 580: 535: 530: 331:copyright status 317:copyright status 285: 271: 266: 257: 254: 251: 248: 245: 204:Creative Commons 198: 197: 192: 191: 157: 144: 136: 130: 114: 93: 92: 86: 80: 78: 65: 58:300 × 480 pixels 54:150 × 240 pixels 48:375 × 600 pixels 918: 917: 913: 912: 911: 909: 908: 907: 842: 816:العلاج البكتيري 802: 798:Living medicine 782: 774: 766: 722: 721: 718: 717: 716: 715: 714: 713: 712: 711: 709: 699: 698: 697: 695: 693:number of pages 683:number of pages 680: 679: 678: 677: 676: 675: 674: 673: 671: 668: 658: 657: 656: 654: 635: 634: 633: 632: 631: 630: 629: 628: 626: 623: 613: 612: 611: 609: 590: 589: 588: 587: 586: 585: 584: 583: 581: 578: 568: 567: 566: 564: 545: 544: 543: 542: 541: 540: 539: 538: 537: 536: 531: 528: 519: 518: 517: 515: 505: 504: 503: 501: 478: 477: 476: 475: 474: 473: 472: 471: 469: 468:application/pdf 459: 458: 457: 455: 440: 439: 438: 437: 436: 435: 434: 433: 431: 421: 420: 419: 417: 402: 401: 400: 399: 398: 397: 396: 395: 393: 381: 380: 379: 377: 358: 357: 356: 355: 354: 353: 352: 351: 349: 337: 336: 335: 333: 314: 313: 312: 311: 310: 308: 292: 291: 290: 267: 262: 259: 258: 255: 252: 249: 246: 243: 242: 210: 199: 185: 180: 147: 134: 127: 120: 119: 108: 107: 106:is shown below. 82: 77:application/pdf 76: 74: 67: 66: 51: 12: 11: 5: 916: 904: 903: 900: 896: 895: 892: 888: 887: 884: 880: 879: 876: 872: 871: 866: 862: 861: 858: 845: 841: 840: 839: 838: 830: 829: 828: 820: 819: 818: 805: 801: 800: 795: 785: 780: 779: 776: 772: 769: 763: 758: 753: 749: 748: 745: 742: 739: 736: 733: 725: 710: 707: 705: 704: 703: 701: 700: 696: 691: 689: 688: 687: 686: 684: 672: 666: 664: 663: 662: 660: 659: 655: 650: 648: 647: 646: 645: 639: 627: 621: 619: 618: 617: 615: 614: 610: 605: 603: 602: 601: 600: 594: 582: 576: 574: 573: 572: 570: 569: 565: 560: 558: 557: 556: 555: 549: 524: 523: 522: 521: 520: 516: 513: 511: 510: 509: 507: 506: 502: 497: 495: 494: 493: 492: 490: 486: 482: 470: 467: 465: 464: 463: 461: 460: 456: 451: 449: 448: 447: 446: 444: 432: 429: 427: 426: 425: 423: 422: 418: 413: 411: 410: 409: 408: 406: 394: 389: 387: 386: 385: 383: 382: 378: 373: 371: 370: 369: 368: 366: 362: 350: 345: 343: 342: 341: 339: 338: 334: 329: 327: 326: 325: 324: 322: 318: 309: 304: 302: 299: 298: 297: 296: 284: 283: 280: 277: 273: 272: 241: 240: 239: 238: 229: 228: 227: 221: 214:You are free: 201: 200: 187: 184: 181: 177: 176: 173: 169: 168: 163: 159: 158: 153: 149: 148: 137: 128: 126: 123: 116: 115: 94: 84: 83: 45: 40: 39: 34: 29: 24: 19: 9: 6: 4: 3: 2: 915: 901: 898: 897: 894:360 x 576 pts 893: 890: 889: 885: 882: 881: 877: 874: 873: 870: 867: 865:Software used 864: 863: 859: 856: 855: 852: 849: 837: 834: 833: 831: 827: 826:باکتری درمانی 824: 823: 821: 817: 814: 813: 811: 810: 809: 799: 796: 794: 791: 790: 789: 775: 770: 764: 762: 759: 757: 754: 751: 750: 746: 743: 740: 737: 734: 732: 731: 729: 706: 694: 690: 665: 653: 649: 620: 608: 604: 575: 563: 559: 534: 527: 512: 500: 496: 466: 454: 450: 428: 416: 412: 392: 388: 376: 372: 348: 344: 332: 328: 307: 303: 300: 281: 274: 270: 265: 260: 236: 233: 232: 230: 225: 222: 219: 216: 215: 213: 212: 208: 205: 193: 174: 170: 167: 164: 160: 150: 143: 138: 131: 112: 105: 104: 99: 95: 88: 87: 81: 72: 71:Original file 63: 59: 55: 49: 44: 38: 35: 33: 30: 28: 25: 23: 20: 18: 15: 850: 847: 807: 787: 765:750 × 1,200 727: 724:File history 430:8 April 2020 234: 223: 217: 156:8 April 2020 141: 111:You can help 101: 69: 22:File history 857:Short title 347:copyrighted 321:copyrighted 235:attribution 133:Description 784:File usage 741:Dimensions 453:media type 443:media type 247:CC BY 4.0 27:File usage 891:Page size 883:Encrypted 836:Q96372956 738:Thumbnail 735:Date/Time 562:data size 548:data size 415:inception 405:inception 183:Licensing 142:English: 844:Metadata 773:Rob Hurt 767:(394 KB) 577:403,562 499:checksum 481:checksum 282:Captions 224:to remix 218:to share 209:license. 37:Metadata 752:current 747:Comment 306:depicts 286:English 125:Summary 73:‎ 622:1,200 607:height 593:height 172:Author 162:Source 669:pixel 652:width 642:pixel 638:width 624:pixel 597:pixel 533:SHA-1 489:SHA-1 744:User 667:750 579:byte 552:byte 256:true 253:true 152:Date 17:File 902:1.7 886:no 529:: 60:| 56:| 50:. 708:1 264:↑ 113:. 79:) 64:.

Index

File
File history
File usage
Global file usage
Metadata
File:Considerations for the design of engineered live bacterial therapeutics.pdf
375 × 600 pixels
150 × 240 pixels
300 × 480 pixels
750 × 1,200 pixels
Original file
Wikimedia Commons
description page there
You can help
https://doi.org/10.1038/s41467-020-15508-1
Creative Commons
Attribution 4.0 International

Template:CC-notice
depicts
copyright status<\/a>"}},"text\/plain":{"en":{"":"copyright status"}}},"{\"value\":{\"entity-type\":\"item\",\"numeric-id\":50423863,\"id\":\"Q50423863\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"P6216":"copyrighted<\/a>"}},"text\/plain":{"en":{"P6216":"copyrighted"}}}}">

copyright status
copyrighted
copyright license<\/a>"}},"text\/plain":{"en":{"":"copyright license"}}},"{\"value\":{\"entity-type\":\"item\",\"numeric-id\":20007257,\"id\":\"Q20007257\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"P275":"Creative Commons Attribution 4.0 International<\/a>"}},"text\/plain":{"en":{"P275":"Creative Commons Attribution 4.0 International"}}}}">

copyright license
Creative Commons Attribution 4.0 International
inception<\/a>"}},"text\/plain":{"en":{"":"inception"}}},"{\"value\":{\"time\":\"+2020-04-08T00:00:00Z\",\"timezone\":0,\"before\":0,\"after\":0,\"precision\":11,\"calendarmodel\":\"http:\\\/\\\/www.wikidata.org\\\/entity\\\/Q1985727\"},\"type\":\"time\"}":{"text\/html":{"en":{"P571":"8 April 2020"}},"text\/plain":{"en":{"P571":"8 April 2020"}}}}">

inception
media type<\/a>"}},"text\/plain":{"en":{"":"media type"}}},"{\"value\":\"application\\\/pdf\",\"type\":\"string\"}":{"text\/html":{"en":{"P1163":"application\/pdf"}},"text\/plain":{"en":{"P1163":"application\/pdf"}}}}">

media type
checksum<\/a>"}},"text\/plain":{"en":{"":"checksum"}}},"{\"value\":\"78cd57837d6817c3c2e096e17b0c5032757ae5d5\",\"type\":\"string\"}":{"text\/html":{"en":{"P4092":"78cd57837d6817c3c2e096e17b0c5032757ae5d5"}},"text\/plain":{"en":{"P4092":"78cd57837d6817c3c2e096e17b0c5032757ae5d5"}}},"{\"value\":{\"entity-type\":\"property\",\"numeric-id\":459,\"id\":\"P459\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"":"determination method<\/a>"}},"text\/plain":{"en":{"":"determination method"}}},"{\"value\":{\"entity-type\":\"item\",\"numeric-id\":13414952,\"id\":\"Q13414952\"},\"type\":\"wikibase-entityid\"}":{"text\/html":{"en":{"P459":"SHA-1<\/a>"}},"text\/plain":{"en":{"P459":"SHA-1"}}}}">