503:
480:
29:
2962:
894:. It is active against both dividing and resting cells. Being phosphorylated, fludarabine is ionized at physiologic pH and is effectually trapped in blood. This provides some level of specificity for blood cells, both cancerous and healthy.
960:
575:
146:
1129:
Gonzalez H, Leblond V, Azar N, Sutton L, Gabarre J, Binet JL, et al. (June 1998). "Severe autoimmune hemolytic anemia in eight patients treated with fludarabine".
914:
Fludarabine is generally administered as its 5-O-phosphorylated form known as fludarabine phosphate, which is rapidly dephosphorylated to fludarabine in the plasma.
2828:
3007:
653:
is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as fludarabine phosphate, sold under the brand name
101:
1158:"Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia"
633:
1240:
830:
51:
2888:
1940:
589:
1769:
1749:
1734:
1046:
1007:
617:
InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
870:
Difficulties are often encountered when harvesting peripheral blood stem cells from patients previously treated with fludarabine.
2156:
2916:
1233:
853:
787:
724:
2523:
1675:
1631:
1509:
640:
1218:
1434:
1206:
1040:
609:
2933:
1226:
1950:
823:
740:
257:
131:
2569:
1571:
1461:
328:
2491:
2474:
2349:
2113:
1491:
794:. Because of its immunosuppressive effects, fludarabine is also used in some conditioning regimens prior to
696:, fever, rash, shortness of breath, numbness, vision changes, and feeling tired. Severe side effects include
2223:
1819:
736:
670:
498:
379:
2997:
2425:
932:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
903:
864:
459:
1815:
1785:
2952:
1605:
682:
448:
1710:
2992:
2791:
2671:
2661:
1060:
931:
674:
2982:
2843:
2776:
2746:
2364:
1614:
887:
475:
2921:
2646:
2361:
1847:
1695:
1622:
811:
791:
658:
83:
41:
2726:
2716:
2449:
2291:
1088:
Rai KR, Peterson BL, Appelbaum FR, Kolitz J, Elias L, Shepherd L, et al. (December 2000).
1030:
795:
678:
214:
428:
3002:
1998:
1645:
1156:
Tournilhac O, Cazin B, Leprètre S, Diviné M, Maloum K, Delmer A, et al. (January 2004).
1003:
319:
61:
1090:"Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia"
368:
2396:
2273:
1794:
388:
283:
224:
8:
2681:
2581:
2560:
2281:
2103:
1935:
1666:
1562:
837:. For this reason, all patients who have ever received fludarabine should only be given
777:
771:
274:
90:
502:
479:
1739:
1248:
764:
2863:
2437:
1271:
1202:
1179:
1138:
1111:
1036:
834:
170:
158:
75:
723:
Fludarabine was approved for medical use in the United States in 1991. It is on the
2987:
2868:
2625:
2340:
1974:
1959:
1680:
1169:
1101:
1068:
748:
515:
308:
196:
114:
829:. The profound lymphopenia caused by fludarabine renders patients susceptible to
2966:
2307:
2269:
2060:
1482:
1397:
204:
1106:
1089:
2927:
2461:
2052:
1546:
1410:
1297:
1267:
1254:
1174:
1157:
891:
815:
697:
814:. People who have been treated with fludarabine will usually be asked to take
265:(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2976:
2801:
2761:
2131:
2004:
1885:
1828:
1586:
1535:
965:
883:
879:
848:, requiring regular blood count monitoring. Some patients require blood and
756:
717:
713:
491:
183:
20:
2848:
2812:
2696:
2686:
2640:
2636:
2598:
2506:
2296:
2235:
2231:
2212:
2207:
2186:
2175:
1989:
1983:
1969:
1964:
1895:
1890:
1843:
1729:
1596:
1576:
1505:
1454:
1444:
1258:
1250:
1183:
1115:
1065:
World Health
Organization model list of essential medicines: 21st list 2019
752:
744:
109:
1142:
2893:
2873:
2858:
2853:
2838:
2796:
2766:
2706:
2676:
2620:
2593:
2466:
2407:
2379:
2369:
2322:
2286:
2202:
2164:
2146:
2141:
2121:
2098:
2069:
2047:
2027:
2017:
1868:
1853:
1833:
1719:
1650:
1636:
1591:
1519:
1496:
1471:
1439:
1382:
1345:
1322:
1307:
1302:
1287:
845:
838:
819:
807:
705:
686:
69:
1073:
882:, and can be given both orally and intravenously. Fludarabine inhibits
348:
2883:
2786:
2781:
2756:
2751:
2741:
2736:
2731:
2701:
2691:
2656:
2651:
2631:
2586:
2574:
2549:
2544:
2534:
2516:
2511:
2501:
2496:
2454:
2442:
2430:
2402:
2389:
2384:
2354:
2317:
2312:
2250:
2245:
2191:
2136:
2088:
2074:
2022:
2009:
1978:
1911:
1900:
1873:
1863:
1858:
1804:
1759:
1754:
1655:
1619:
1551:
1541:
1530:
1514:
1466:
1449:
1425:
1377:
1365:
1317:
902:
Fludarabine was produced by John
Montgomery and Kathleen Hewson of the
857:
783:
551:
359:
2898:
2878:
2833:
2823:
2817:
2721:
2666:
2615:
2539:
2529:
2484:
2471:
2412:
2374:
2302:
2240:
2181:
2170:
2126:
2083:
2042:
2036:
2032:
1994:
1921:
1916:
1906:
1878:
1838:
1799:
1774:
1764:
1724:
1370:
1360:
1355:
1350:
1312:
760:
709:
701:
294:
237:
55:
2807:
2771:
2711:
2479:
2417:
2197:
2093:
2065:
1744:
1581:
849:
767:
693:
666:
662:
408:
339:
94:
574:
1700:
1601:
1415:
1276:
1340:
712:
will likely result in harm to the fetus. Fludarabine is in the
439:
242:
28:
1155:
565:
419:
464:
399:
1087:
1128:
1059:
939:
863:
Fludarabine is associated with the development of severe
1077:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
747:
alone. Fludarabine is used in various combinations with
716:
family of medications and works by interfering with the
725:
2950:
1032:
1006:. The American Society of Health-System Pharmacists.
735:
Fludarabine is highly effective in the treatment of
1035:. Lippincott Williams & Wilkins. p. 2309.
924:
327:
2974:
844:Fludarabine causes anemia, thrombocytopenia and
831:transfusion-associated graft versus host disease
307:
282:
810:, and as a consequence, increases the risk of
3008:World Health Organization essential medicines
1234:
782:regimen, fludarabine is used together with
1241:
1227:
998:
996:
994:
992:
990:
988:
986:
984:
501:
478:
367:
27:
1173:
1149:
1105:
1072:
1028:
387:
961:"Product monograph brand safety updates"
806:Fludarabine is associated with profound
1196:
1122:
981:
739:, producing higher response rates than
474:
347:
74:
2975:
1190:
1053:
833:, an oftentimes fatal complication of
492:
164:
1222:
1067:. Geneva: World Health Organization.
1010:from the original on 21 December 2016
788:granulocyte colony-stimulating factor
447:
427:
177:
60:
692:Common side effects include nausea,
113:
1510:ribonucleotide reductase inhibitors
1094:The New England Journal of Medicine
407:
298:
13:
1676:Ribonucleotide reductase inhibitor
1632:Ribonucleotide reductase inhibitor
1081:
14:
3019:
1435:Dihydrofolate reductase inhibitor
140:
2960:
1201:. New York: Wiley. p. 258.
1049:from the original on 2016-12-20.
535:
532:
526:
873:
801:
796:allogeneic stem cell transplant
730:
622:Key:HBUBKKRHXORPQB-FJFJXFQQSA-N
1572:Thymidylate synthase inhibitor
1462:Thymidylate synthase inhibitor
1022:
953:
597:Fc1nc(c2ncn(c2n1)3O((O)3O)CO)N
541:
520:
153:
1:
1492:Adenosine deaminase inhibitor
1333:Block microtubule disassembly
917:
867:in a proportion of patients.
818:or to use monthly nebulised
737:chronic lymphocytic leukemia
671:chronic lymphocytic leukemia
7:
1131:Hematology and Cell Therapy
1107:10.1056/NEJM200012143432402
904:Southern Research Institute
865:autoimmune hemolytic anemia
10:
3024:
1175:10.1182/blood-2003-05-1449
1029:Helms RA, Quan DJ (2006).
897:
683:acute lymphocytic leukemia
510:Chemical and physical data
2911:
2792:Omacetaxine mepesuccinate
2672:Ciltacabtagene autoleucel
2662:Brexucabtagene autoleucel
2608:
2559:
2339:
2332:
2268:
2222:
2155:
2112:
1949:
1934:
1814:
1784:
1709:
1694:
1665:
1561:
1481:
1424:
1407:
1396:
1332:
1285:
1266:
1199:Drug discovery: a history
1061:World Health Organization
661:used in the treatment of
630:
605:
585:
563:
550:
514:
509:
490:
458:
438:
418:
398:
378:
358:
338:
318:
293:
273:
253:
248:
236:
223:
213:
203:
195:
130:
125:
100:
82:
68:
50:
40:
35:
26:
2844:Talimogene laherparepvec
2777:Nadofaragene firadenovec
2747:Lisocabtagene maraleucel
1696:Topoisomerase inhibitors
1615:DNA polymerase inhibitor
909:
888:ribonucleotide reductase
812:opportunistic infections
2647:Axicabtagene ciloleucel
1251:chemotherapeutic agents
1004:"Fludarabine Phosphate"
792:acute myeloid leukaemia
768:non-Hodgkin's lymphomas
659:chemotherapy medication
657:among others. It is a
2829:Sitimagene ceradenovec
2727:Idecabtagene vicleucel
2292:Methyl aminolevulinate
679:acute myeloid leukemia
675:non-Hodgkin's lymphoma
2303:Porphyrin derivatives
1999:Melphalan flufenamide
1646:Hypomethylating agent
1255:antineoplastic agents
825:Pneumocystis jiroveci
702:low blood cell counts
687:injection into a vein
2632:Asparagine depleters
2561:Receptor antagonists
2475:+abiraterone acetate
886:by interfering with
856:injections to boost
790:in the treatment of
763:in the treatment of
2682:Denileukin diftitox
2582:Retinoid X receptor
2282:Aminolevulinic acid
2104:Triethylenemelamine
1936:Crosslinking of DNA
1667:Deoxyribonucleotide
1606:+gimeracil/oteracil
173:(Prescription only)
149:(Prescription only)
23:
2998:Purine antagonists
2938:Never to phase III
1740:Etirinotecan pegol
1197:Sneader W (2005).
841:blood components.
770:. As part of the
718:duplication of DNA
19:
2948:
2947:
2907:
2906:
2864:Tigilanol tiglate
2341:Enzyme inhibitors
2264:
2263:
2260:
2259:
1960:Nitrogen mustards
1930:
1929:
1690:
1689:
1392:
1391:
1100:(24): 1750–1757.
878:Fludarabine is a
835:blood transfusion
741:alkylating agents
706:lung inflammation
698:brain dysfunction
685:. It is given by
648:
647:
576:Interactive image
460:CompTox Dashboard
181:
168:
156:
144:
16:Chemical compound
3015:
2993:Organophosphates
2965:
2964:
2963:
2956:
2869:Tisagenlecleucel
2626:Arsenic trioxide
2337:
2336:
2270:Photosensitizers
2061:Alkyl sulfonates
1975:Cyclophosphamide
1947:
1946:
1886:Anthracenediones
1707:
1706:
1681:Hydroxycarbamide
1422:
1421:
1405:
1404:
1283:
1282:
1243:
1236:
1229:
1220:
1219:
1213:
1212:
1194:
1188:
1187:
1177:
1153:
1147:
1146:
1126:
1120:
1119:
1109:
1085:
1079:
1078:
1076:
1057:
1051:
1050:
1026:
1020:
1019:
1017:
1015:
1000:
979:
978:
976:
974:
957:
951:
950:
948:
946:
936:nctr-crs.fda.gov
928:
852:transfusion, or
749:cyclophosphamide
669:. These include
644:
643:
636:
578:
558:
543:
537:
534:
528:
522:
505:
494:
483:
482:
468:
466:
451:
431:
411:
391:
371:
351:
331:
311:
301:
300:
286:
228:
186:
179:
176:
166:
163:
155:
152:
142:
139:
117:
78:
64:
31:
24:
22:
18:
3023:
3022:
3018:
3017:
3016:
3014:
3013:
3012:
2983:Organofluorides
2973:
2972:
2971:
2961:
2959:
2951:
2949:
2944:
2943:
2928:Clinical trials
2903:
2609:Other/ungrouped
2604:
2555:
2328:
2308:Porfimer sodium
2256:
2218:
2151:
2108:
1938:
1926:
1810:
1780:
1698:
1686:
1661:
1557:
1477:
1413:
1411:antimetabolites
1409:
1408:DNA precursors/
1400:
1398:DNA replication
1388:
1328:
1298:Vinca alkaloids
1274:
1262:
1247:
1217:
1216:
1209:
1195:
1191:
1154:
1150:
1127:
1123:
1086:
1082:
1058:
1054:
1043:
1027:
1023:
1013:
1011:
1002:
1001:
982:
972:
970:
959:
958:
954:
944:
942:
930:
929:
925:
920:
912:
900:
876:
804:
733:
639:
637:
634:(what is this?)
631:
626:
623:
618:
613:
612:
601:
598:
593:
592:
581:
556:
546:
540:
531:
525:
486:
462:
454:
434:
414:
394:
374:
354:
334:
314:
297:
289:
269:
266:
261:
260:
226:
215:Protein binding
205:Bioavailability
197:Pharmacokinetic
191:
184:
121:
85:
46:Fludara, others
17:
12:
11:
5:
3021:
3011:
3010:
3005:
3000:
2995:
2990:
2985:
2970:
2969:
2946:
2945:
2942:
2941:
2940:
2939:
2936:
2925:
2919:
2913:
2912:
2909:
2908:
2905:
2904:
2902:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2815:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2628:
2623:
2618:
2612:
2610:
2606:
2605:
2603:
2602:
2590:
2578:
2565:
2563:
2557:
2556:
2554:
2553:
2547:
2542:
2537:
2532:
2520:
2514:
2509:
2504:
2499:
2488:
2482:
2477:
2469:
2462:PARP inhibitor
2458:
2446:
2434:
2422:
2421:
2420:
2415:
2410:
2405:
2393:
2387:
2382:
2377:
2372:
2358:
2345:
2343:
2334:
2330:
2329:
2327:
2326:
2320:
2315:
2310:
2299:
2294:
2289:
2284:
2278:
2276:
2266:
2265:
2262:
2261:
2258:
2257:
2255:
2254:
2248:
2243:
2238:
2228:
2226:
2220:
2219:
2217:
2216:
2210:
2205:
2194:
2189:
2184:
2179:
2167:
2161:
2159:
2153:
2152:
2150:
2149:
2144:
2139:
2134:
2129:
2124:
2118:
2116:
2114:Platinum-based
2110:
2109:
2107:
2106:
2101:
2096:
2091:
2079:
2078:
2072:
2056:
2055:
2050:
2045:
2040:
2030:
2025:
2013:
2012:
2007:
2002:
1992:
1987:
1981:
1972:
1967:
1955:
1953:
1944:
1932:
1931:
1928:
1927:
1925:
1924:
1919:
1914:
1909:
1904:
1898:
1893:
1882:
1876:
1871:
1866:
1861:
1856:
1851:
1841:
1836:
1829:Anthracyclines
1824:
1822:
1812:
1811:
1809:
1808:
1802:
1790:
1788:
1782:
1781:
1779:
1778:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1715:
1713:
1704:
1692:
1691:
1688:
1687:
1685:
1684:
1671:
1669:
1663:
1662:
1660:
1659:
1653:
1641:
1640:
1627:
1626:
1610:
1609:
1599:
1594:
1589:
1584:
1579:
1567:
1565:
1559:
1558:
1556:
1555:
1549:
1547:Mercaptopurine
1538:
1533:
1528:
1522:
1517:
1501:
1500:
1487:
1485:
1479:
1478:
1476:
1475:
1469:
1458:
1452:
1447:
1442:
1430:
1428:
1419:
1402:
1394:
1393:
1390:
1389:
1387:
1386:
1374:
1368:
1363:
1358:
1353:
1348:
1336:
1334:
1330:
1329:
1327:
1326:
1320:
1315:
1310:
1305:
1293:
1291:
1280:
1264:
1263:
1249:Intracellular
1246:
1245:
1238:
1231:
1223:
1215:
1214:
1207:
1189:
1168:(1): 363–365.
1148:
1137:(3): 113–118.
1121:
1080:
1052:
1041:
1021:
980:
952:
922:
921:
919:
916:
911:
908:
899:
896:
892:DNA polymerase
875:
872:
816:co-trimoxazole
803:
800:
732:
729:
646:
645:
628:
627:
625:
624:
621:
619:
616:
608:
607:
606:
603:
602:
600:
599:
596:
588:
587:
586:
583:
582:
580:
579:
571:
569:
561:
560:
554:
548:
547:
544:
538:
529:
523:
518:
512:
511:
507:
506:
496:
488:
487:
485:
484:
471:
469:
456:
455:
453:
452:
444:
442:
436:
435:
433:
432:
424:
422:
416:
415:
413:
412:
404:
402:
396:
395:
393:
392:
384:
382:
376:
375:
373:
372:
364:
362:
356:
355:
353:
352:
344:
342:
336:
335:
333:
332:
324:
322:
316:
315:
313:
312:
304:
302:
291:
290:
288:
287:
279:
277:
271:
270:
268:
267:
264:
256:
255:
254:
251:
250:
246:
245:
240:
234:
233:
230:
221:
220:
217:
211:
210:
207:
201:
200:
193:
192:
190:
189:
174:
161:
150:
136:
134:
128:
127:
123:
122:
120:
119:
106:
104:
98:
97:
88:
86:administration
80:
79:
72:
66:
65:
58:
48:
47:
44:
38:
37:
33:
32:
15:
9:
6:
4:
3:
2:
3020:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2980:
2978:
2968:
2958:
2957:
2954:
2937:
2935:
2932:
2931:
2929:
2926:
2923:
2920:
2918:
2915:
2914:
2910:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2819:
2816:
2814:
2810:
2809:
2805:
2803:
2802:Tabelecleucel
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2762:Lurbinectedin
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2642:
2638:
2634:
2633:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2613:
2611:
2607:
2600:
2596:
2595:
2591:
2588:
2584:
2583:
2579:
2576:
2572:
2571:
2567:
2566:
2564:
2562:
2558:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2527:
2525:
2521:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2494:
2493:
2489:
2486:
2483:
2481:
2478:
2476:
2473:
2470:
2468:
2464:
2463:
2459:
2456:
2452:
2451:
2447:
2444:
2440:
2439:
2435:
2432:
2428:
2427:
2423:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2400:
2399:
2398:
2394:
2391:
2388:
2386:
2383:
2381:
2378:
2376:
2373:
2371:
2367:
2366:
2363:
2359:
2356:
2352:
2351:
2347:
2346:
2344:
2342:
2338:
2335:
2331:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2305:
2304:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2279:
2277:
2275:
2271:
2267:
2252:
2249:
2247:
2244:
2242:
2239:
2237:
2233:
2230:
2229:
2227:
2225:
2224:Intercalation
2221:
2214:
2211:
2209:
2206:
2204:
2200:
2199:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2177:
2173:
2172:
2168:
2166:
2163:
2162:
2160:
2158:
2154:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2132:Dicycloplatin
2130:
2128:
2125:
2123:
2120:
2119:
2117:
2115:
2111:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2081:
2080:
2076:
2073:
2071:
2067:
2064:
2062:
2058:
2057:
2054:
2051:
2049:
2046:
2044:
2041:
2038:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2015:
2014:
2011:
2008:
2006:
2005:Prednimustine
2003:
2000:
1996:
1993:
1991:
1988:
1985:
1982:
1980:
1976:
1973:
1971:
1968:
1966:
1963:
1961:
1957:
1956:
1954:
1952:
1948:
1945:
1942:
1937:
1933:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1902:
1899:
1897:
1894:
1892:
1888:
1887:
1883:
1880:
1877:
1875:
1872:
1870:
1867:
1865:
1862:
1860:
1857:
1855:
1852:
1849:
1845:
1842:
1840:
1837:
1835:
1831:
1830:
1826:
1825:
1823:
1821:
1820:Intercalation
1817:
1813:
1806:
1803:
1801:
1797:
1796:
1792:
1791:
1789:
1787:
1783:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1722:
1721:
1717:
1716:
1714:
1712:
1708:
1705:
1702:
1697:
1693:
1682:
1678:
1677:
1673:
1672:
1670:
1668:
1664:
1657:
1654:
1652:
1648:
1647:
1643:
1642:
1638:
1634:
1633:
1629:
1628:
1624:
1623:+daunorubicin
1621:
1617:
1616:
1612:
1611:
1607:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1587:Doxifluridine
1585:
1583:
1580:
1578:
1574:
1573:
1569:
1568:
1566:
1564:
1560:
1553:
1550:
1548:
1544:
1543:
1539:
1537:
1536:Rabacfosadine
1534:
1532:
1529:
1526:
1523:
1521:
1518:
1516:
1512:
1511:
1507:
1503:
1502:
1498:
1494:
1493:
1489:
1488:
1486:
1484:
1480:
1473:
1470:
1468:
1464:
1463:
1459:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1437:
1436:
1432:
1431:
1429:
1427:
1423:
1420:
1417:
1412:
1406:
1403:
1399:
1395:
1384:
1380:
1379:
1375:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1343:
1342:
1338:
1337:
1335:
1331:
1324:
1321:
1319:
1316:
1314:
1311:
1309:
1306:
1304:
1300:
1299:
1295:
1294:
1292:
1289:
1284:
1281:
1278:
1273:
1269:
1265:
1260:
1256:
1252:
1244:
1239:
1237:
1232:
1230:
1225:
1224:
1221:
1210:
1208:0-471-89979-8
1204:
1200:
1193:
1185:
1181:
1176:
1171:
1167:
1163:
1159:
1152:
1144:
1140:
1136:
1132:
1125:
1117:
1113:
1108:
1103:
1099:
1095:
1091:
1084:
1075:
1070:
1066:
1062:
1056:
1048:
1044:
1042:9780781757348
1038:
1034:
1033:
1025:
1009:
1005:
999:
997:
995:
993:
991:
989:
987:
985:
969:. 7 July 2016
968:
967:
966:Health Canada
962:
956:
941:
937:
933:
927:
923:
915:
907:
905:
895:
893:
889:
885:
884:DNA synthesis
881:
880:purine analog
871:
868:
866:
861:
859:
855:
851:
847:
842:
840:
836:
832:
828:
826:
821:
817:
813:
809:
799:
797:
793:
789:
785:
781:
780:
775:
774:
769:
766:
762:
758:
757:dexamethasone
754:
750:
746:
742:
738:
728:
726:
721:
719:
715:
714:purine analog
711:
707:
703:
699:
695:
690:
689:or by mouth.
688:
684:
680:
676:
672:
668:
664:
660:
656:
652:
642:
635:
629:
620:
615:
614:
611:
604:
595:
594:
591:
584:
577:
573:
572:
570:
567:
562:
555:
553:
549:
519:
517:
513:
508:
504:
500:
497:
495:
493:ECHA InfoCard
489:
481:
477:
476:DTXSID2023060
473:
472:
470:
461:
457:
450:
446:
445:
443:
441:
437:
430:
426:
425:
423:
421:
417:
410:
406:
405:
403:
401:
397:
390:
386:
385:
383:
381:
377:
370:
366:
365:
363:
361:
357:
350:
346:
345:
343:
341:
337:
330:
326:
325:
323:
321:
317:
310:
306:
305:
303:
296:
292:
285:
281:
280:
278:
276:
272:
263:
262:
259:
252:
247:
244:
241:
239:
235:
231:
229:
222:
218:
216:
212:
208:
206:
202:
198:
194:
187:
175:
172:
162:
160:
151:
148:
138:
137:
135:
133:
129:
124:
116:
111:
108:
107:
105:
103:
99:
96:
92:
89:
87:
81:
77:
73:
71:
67:
63:
59:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
3003:Arabinosides
2849:Tazemetostat
2813:Alitretinoin
2806:
2717:Estramustine
2697:Elsamitrucin
2687:Eflornithine
2641:Pegaspargase
2637:Asparaginase
2630:
2599:Testolactone
2592:
2580:
2568:
2522:
2507:Panobinostat
2490:
2460:
2448:
2436:
2424:
2395:
2360:
2348:
2301:
2297:Padeliporfin
2236:Dactinomycin
2232:Streptomyces
2213:Temozolomide
2208:Mitozolomide
2196:
2187:Mitobronitol
2176:Procarbazine
2169:
2157:Nonclassical
2082:
2059:
2053:Streptozocin
2018:Nitrosoureas
2016:
1990:Chlorambucil
1984:Trofosfamide
1970:Chlormethine
1965:Bendamustine
1958:
1896:Mitoxantrone
1891:Losoxantrone
1884:
1844:Daunorubicin
1827:
1793:
1730:Camptothecin
1718:
1674:
1644:
1630:
1613:
1597:Fluorouracil
1577:Capecitabine
1570:
1540:
1524:
1504:
1490:
1460:
1455:Pralatrexate
1445:Methotrexate
1433:
1376:
1339:
1296:
1198:
1192:
1165:
1161:
1151:
1134:
1130:
1124:
1097:
1093:
1083:
1074:10665/325771
1064:
1055:
1031:
1024:
1012:. Retrieved
971:. Retrieved
964:
955:
943:. Retrieved
935:
926:
913:
901:
877:
874:Pharmacology
869:
862:
843:
824:
805:
802:Side effects
778:
772:
753:mitoxantrone
745:chlorambucil
734:
731:Medical uses
722:
691:
654:
650:
649:
638:
632:
225:Elimination
132:Legal status
126:Legal status
2924:from market
2894:Vorasidenib
2874:Trabectedin
2859:Tiazofurine
2854:Tebentafusp
2839:Tagraxofusp
2797:Plitidepsin
2767:Mitoguazone
2707:Epacadostat
2677:Demecolcine
2621:Aflibercept
2594:Sex steroid
2467:Fuzuloparib
2408:Carfilzomib
2380:Palbociclib
2370:Abemaciclib
2323:Verteporfin
2287:Efaproxiral
2203:Dacarbazine
2165:Altretamine
2147:Satraplatin
2142:Oxaliplatin
2122:Carboplatin
2099:Triaziquone
2070:Mannosulfan
2048:Ranimustine
2028:Fotemustine
1869:Pirarubicin
1854:Doxorubicin
1848:+cytarabine
1834:Aclarubicin
1795:Podophyllum
1720:Camptotheca
1651:Azacitidine
1637:Gemcitabine
1592:Floxuridine
1525:Fludarabine
1520:Clofarabine
1506:Halogenated
1497:Pentostatin
1472:Raltitrexed
1440:Aminopterin
1383:Ixabepilone
1378:Epothilones
1346:Cabazitaxel
1323:Vinorelbine
1308:Vincristine
1303:Vinblastine
1288:microtubule
846:neutropenia
822:to prevent
820:pentamidine
808:lymphopenia
651:Fludarabine
559: g·mol
499:100.123.703
429:CHEBI:63599
249:Identifiers
91:Intravenous
70:MedlinePlus
42:Trade names
21:Fludarabine
2977:Categories
2889:Verdinexor
2884:Venetoclax
2787:Oblimersen
2782:Navitoclax
2757:Lucanthone
2752:Lonidamine
2742:Lifileucel
2737:Ivosidenib
2732:Imetelstat
2702:Enasidenib
2692:Elesclomol
2657:Bexarotene
2652:Belzutifan
2587:Bexarotene
2575:Atrasentan
2550:Umbralisib
2545:Idelalisib
2535:Copanlisib
2517:Vorinostat
2512:Romidepsin
2502:Entinostat
2497:Belinostat
2455:Masoprocol
2443:Tiazofurin
2431:Anagrelide
2403:Bortezomib
2390:Seliciclib
2385:Ribociclib
2365:inhibitors
2355:Tipifarnib
2318:Temoporfin
2313:Talaporfin
2251:Plicamycin
2246:Mitomycins
2192:Pipobroman
2171:Hydrazines
2137:Nedaplatin
2089:Carboquone
2084:Aziridines
2075:Treosulfan
2023:Carmustine
2010:Uramustine
1979:Ifosfamide
1951:Alkylating
1912:Bisantrene
1901:Pixantrone
1874:Valrubicin
1864:Idarubicin
1859:Epirubicin
1805:Teniposide
1760:Lurtotecan
1755:Irinotecan
1656:Decitabine
1620:Cytarabine
1563:Pyrimidine
1552:Tioguanine
1542:Thiopurine
1531:Nelarabine
1515:Cladribine
1467:Pemetrexed
1450:Pemetrexed
1426:Folic acid
1366:Paclitaxel
1318:Vinflunine
1014:8 December
918:References
858:neutrophil
839:irradiated
784:cytarabine
564:3D model (
552:Molar mass
449:ChEMBL1568
389:P2K93U8740
360:ChemSpider
320:IUPHAR/BPS
284:21679-14-1
275:CAS Number
258:IUPAC name
2934:Phase III
2922:Withdrawn
2899:Vosaroxin
2879:Veliparib
2834:Sotorasib
2824:Selinexor
2818:Tretinoin
2808:Retinoids
2722:Glasdegib
2667:Celecoxib
2616:Adagrasib
2540:Duvelisib
2530:Alpelisib
2485:Rucaparib
2472:Niraparib
2413:Oprozomib
2375:Alvocidib
2241:Bleomycin
2198:Triazenes
2182:Etoglucid
2127:Cisplatin
2043:Nimustine
2037:Semustine
2033:Lomustine
1995:Melphalan
1922:Menogaril
1917:Crisnatol
1907:Amsacrine
1879:Zorubicin
1839:Amrubicin
1800:Etoposide
1775:Topotecan
1770:Silatecan
1765:Rubitecan
1750:Gimatecan
1735:Cositecan
1725:Belotecan
1401:inhibitor
1371:Tesetaxel
1361:Ortataxel
1356:Larotaxel
1351:Docetaxel
1313:Vindesine
906:in 1968.
827:pneumonia
761:rituximab
710:pregnancy
708:. Use in
238:Excretion
227:half-life
219:19 to 29%
84:Routes of
62:Monograph
56:Drugs.com
2967:Medicine
2772:Mitotane
2712:Eribulin
2480:Olaparib
2418:Ixazomib
2094:Thiotepa
2066:Busulfan
1745:Exatecan
1582:Carmofur
1290:assembly
1253: /
1184:12969985
1116:11114313
1063:(2019).
1047:Archived
1008:Archived
860:counts.
850:platelet
765:indolent
743:such as
694:diarrhea
667:lymphoma
663:leukemia
641:(verify)
340:DrugBank
232:20 hours
102:ATC code
95:by mouth
2988:Purines
1701:S phase
1602:Tegafur
1416:S phase
1341:Taxanes
1277:M phase
1143:9698219
973:3 April
898:History
655:Fludara
557:285.235
516:Formula
349:DB01073
295:PubChem
188:Rx-only
185:WARNING
157::
118:)
112: (
110:L01BB05
76:a692003
2953:Portal
2917:WHO-EM
2526:(Pi3K)
1483:Purine
1286:Block
1205:
1182:
1141:
1114:
1039:
945:22 Oct
779:FLAMSA
704:, and
681:, and
590:SMILES
440:ChEMBL
409:D01907
369:571392
309:657237
243:Kidney
182:
169:
159:â„ž-only
145:
2438:IMPDI
2333:Other
1162:Blood
910:Names
854:G-CSF
610:InChI
566:JSmol
420:ChEBI
2524:PIKI
2492:HDAC
1941:CCNS
1203:ISBN
1180:PMID
1139:PMID
1112:PMID
1037:ISBN
1016:2016
975:2024
947:2023
890:and
786:and
773:FLAG
759:and
665:and
400:KEGG
380:UNII
329:4802
199:data
52:AHFS
2570:ERA
2426:PhI
2397:PrI
2362:CDK
2274:PDT
1272:MIs
1268:SPs
1259:L01
1170:doi
1166:103
1102:doi
1098:343
1069:hdl
940:FDA
776:or
465:EPA
299:CID
209:55%
171:POM
115:WHO
2979::
2930::
2450:LI
2350:FI
1816:II
1786:II
1608:))
1178:.
1164:.
1160:.
1135:40
1133:.
1110:.
1096:.
1092:.
1045:.
983:^
963:.
938:.
934:.
798:.
755:,
751:,
727:.
720:.
700:,
677:,
673:,
530:12
524:10
178:US
165:UK
154:CA
147:S4
141:AU
93:,
2955::
2820:)
2811:(
2643:)
2639:/
2635:(
2601:)
2597:(
2589:)
2585:(
2577:)
2573:(
2552:)
2528:(
2519:)
2495:(
2487:)
2465:(
2457:)
2453:(
2445:)
2441:(
2433:)
2429:(
2392:)
2368:(
2357:)
2353:(
2325:)
2306:(
2272:/
2253:)
2234:(
2215:)
2201:(
2178:)
2174:(
2086::
2077:)
2068:(
2063::
2039:)
2035:(
2020::
2001:)
1997:(
1986:)
1977:(
1962::
1943:)
1939:(
1903:)
1889:(
1881:)
1850:)
1846:(
1832:(
1818:+
1807:)
1798:(
1777:)
1723:(
1711:I
1703:)
1699:(
1683:)
1679:(
1658:)
1649:(
1639:)
1635:(
1625:)
1618:(
1604:(
1575:(
1554:)
1545:(
1527:)
1513:(
1508:/
1499:)
1495:(
1474:)
1465:(
1457:)
1438:(
1418:)
1414:(
1385:)
1381:(
1373:)
1344:(
1325:)
1301:(
1279:)
1275:(
1270:/
1261:)
1257:(
1242:e
1235:t
1228:v
1211:.
1186:.
1172::
1145:.
1118:.
1104::
1071::
1018:.
977:.
949:.
568:)
545:4
542:O
539:5
536:N
533:F
527:H
521:C
467:)
463:(
180::
167::
143::
54:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
