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GABA

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of a GABA-A receptor thus leads to efflux of Cl ions from the cell (that is, a depolarizing current). The differential gradient of chloride in immature neurons was shown to be primarily due to the higher concentration of NKCC1 co-transporters relative to KCC2 co-transporters in immature cells. GABAergic interneurons mature faster in the hippocampus and the GABA machinery appears earlier than glutamatergic transmission. Thus, GABA is considered the major excitatory neurotransmitter in many regions of the brain before the
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ions across the membrane of the cell. Whether this chloride flow is depolarizing (makes the voltage across the cell's membrane less negative), shunting (has no effect on the cell's membrane potential), or inhibitory/hyperpolarizing (makes the cell's membrane more negative) depends on the direction of
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GABA is an inhibitory transmitter in the mature brain; its actions were thought to be primarily excitatory in the developing brain. The gradient of chloride was reported to be reversed in immature neurons, with its reversal potential higher than the resting membrane potential of the cell; activation
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of the cell's membrane. Shunting inhibition can "override" the excitatory effect of depolarising GABA, resulting in overall inhibition even if the membrane potential becomes less negative. It was thought that a developmental switch in the molecular machinery controlling the concentration of chloride
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Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P (2017).
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calculations. In the solid state, an extended conformation is found, with a trans conformation at the amino end and a gauche conformation at the carboxyl end. This is due to the packing interactions with the neighboring molecules. In solution, five different conformations, some folded and some
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effects. The conformational flexibility of GABA is important for its biological function, as it has been found to bind to different receptors with different conformations. Many GABA analogues with pharmaceutical applications have more rigid structures in order to control the binding better.
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Experiments on mice have shown that hypothyroidism induced by fluoride poisoning can be halted by administering GABA. The test also found that the thyroid recovered naturally without further assistance after the fluoride had been expelled by the GABA.
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the flow of chloride. When net chloride flows out of the cell, GABA is depolarising; when chloride flows into the cell, GABA is inhibitory or hyperpolarizing. When the net flow of chloride is close to zero, the action of GABA is shunting.
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Xiang YY, Wang S, Liu M, Hirota JA, Li J, Ju W, Fan Y, Kelly MM, Ye B, Orser B, O'Byrne PM, Inman MD, Yang X, Lu WY (July 2007). "A GABAergic system in airway epithelium is essential for mucus overproduction in asthma".
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depends on its environment. In the gas phase, a highly folded conformation is strongly favored due to the electrostatic attraction between the two functional groups. The stabilization is about 50 kcal/mol, according to
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In 1959, it was shown that at an inhibitory synapse on crayfish muscle fibers GABA acts like stimulation of the inhibitory nerve. Both inhibition by nerve stimulation and by applied GABA are blocked by
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Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL (1997). "Sites of alcohol and volatile anaesthetic action on GABA
1001:, are also able to excite their glutamatergic counterparts. In addition to fast-acting phasic inhibition, small amounts of extracellular GABA can induce slow timescale tonic inhibition on neurons. 8253: 8903: 7135: 8840: 7734: 5301:
Boehm SL, Ponomarev I, Jennings AW, Whiting PJ, Rosahl TW, Garrett EM, Blednov YA, Harris RA (2004). "γ-Aminobutyric acid a receptor subunit mutant mice: New perspectives on alcohol actions".
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Obrietan K, Gao XB, Van Den Pol AN (August 2002). "Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism—a positive feedback circuit in developing neurons".
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Pinna G, Costa E, Guidotti A (June 2006). "Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake".
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Purwana I, Zheng J, Li X, Deurloo M, Son DO, Zhang Z, Liang C, Shen E, Tadkase A, Feng ZP, Li Y, Hasilo C, Paraskevas S, Bortell R, Greiner DL, Atkinson M, Prud'homme GJ, Wang Q (2014).
8850: 8825: 9365: 4423:"The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat" 8627: 8642: 6557: 9507: 8908: 8775: 7690: 7660: 9681: 8855: 8888: 4078:
Sequerra, E. B.; Gardino, P.; Hedin-Pereira, C.; de Mello, F. G. (2007-05-11). "Putrescine as an important source of GABA in the postnatal rat subventricular zone".
6255: 1459:) in rats. It is thus suspected that GABA is involved in the synthesis of melatonin and thus might exert regulatory effects on sleep and reproductive functions. 9896: 9859: 9358: 2915:"GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor/Cl channels" 9911: 9548: 9422: 9257: 8928: 8873: 7525: 2491:
Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R (October 2007). "GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations".
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Hosie AM, Wilkins ME, da Silva HM, Smart TG (November 2006). "Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites".
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Rorsman P, Berggren PO, Bokvist K, Ericson H, Möhler H, Ostenson CG, Smith PA (1989). "Glucose-inhibition of glucagon secretion involves activation of GABA
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Majumdar D, Guha S (1988). "Conformation, electrostatic potential and pharmacophoric pattern of GABA (γ-aminobutyric acid) and several GABA inhibitors".
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Soltani N, Qiu H, Aleksic M, Glinka Y, Zhao F, Liu R, Li Y, Zhang N, Chakrabarti R, Ng T, Jin T, Zhang H, Lu WY, Feng ZP, Prud'homme GJ, Wang Q (2011).
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Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E (May 1990). "Neurosteroids act on recombinant human GABAA receptors".
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Szabadics J, Varga C, Molnár G, Oláh S, Barzó P, Tamás G (January 2006). "Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits".
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GABA can promote the replication and survival of β-cells and also promote the conversion of α-cells to β-cells, which may lead to new treatments for
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drugs), or increase the available amount of GABA, typically have relaxing, anti-anxiety, and anti-convulsive effects (with equivalent efficacy to
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W. G. Van der Kloot; J. Robbins (1959). "The effects of GABA and picrotoxin on the junctional potential and the contraction of crayfish muscle".
1433:, can be reached by drugs such as systemically injected GABA. At least one study suggests that orally administered GABA increases the amount of 2012: 5874:
Ramesh SA, Tyerman SD, Xu B, Bose J, Kaur S, Conn V, Domingos P, Ullah S, Wege S, Shabala S, Feijó JA, Ryan PR, Gilliham M, Gillham M (2015).
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Barbin G, Pollard H, Gaïarsa JL, Ben-Ari Y (April 1993). "Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons".
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has no direct effect on the membrane potential of the cell; however, it reduces the effect of any coincident synaptic input by reducing the
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Koh, Wuhyun; Kwak, Hankyul; Cheong, Eunji; Lee, C. Justin (2023-07-26). "GABA tone regulation and its cognitive functions in the brain".
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Kuriyama K, Sze PY (January 1971). "Blood–brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated animals".
8404: 8163: 3592:"Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model" 1107: 9212: 3446:
Yang H, Xing R, Liu S, Yu H, Li P (2016). "γ-Aminobutyric acid ameliorates fluoride-induced hypothyroidism in male Kunming mice".
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Celikyurt IK, Mutlu O, Ulak G, Akar FY, Erden F (2011). "Gabapentin, A GABA analogue, enhances cognitive performance in mice".
3800:"GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5" 9916: 5858: 5585:
Jira, Reinhard; Kopp, Erwin; McKusick, Blaine C.; Röderer, Gerhard; Bosch, Axel; Fleischmann, Gerald. "Chloroacetaldehydes".
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In the developmental stages preceding the formation of synaptic contacts, GABA is synthesized by neurons and acts both as an
1021: 414: 8692: 1479:. GABA is not an alpha amino acid, meaning the amino group is not attached to the alpha carbon. Nor is it incorporated into 6836: 4673:
Herd MB, Belelli D, Lambert JJ (October 2007). "Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors".
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in many countries. It has been traditionally thought that exogenous GABA (i.e., taken as a supplement) does not cross the
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Alongside GABAergic mechanisms, GABA has also been detected in other peripheral tissues including intestines, stomach,
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Bhandage AK, Jin Z, Korol SV, Shen Q, Pei Y, Deng Q, Espes D, Carlsson PO, Kamali-Moghaddam M, Birnir B (April 2018).
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Boehm SL, Ponomarev I, Blednov YA, Harris RA (2006). "From Gene to Behavior and Back Again: New Perspectives on GABA
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Phulera, Swastik; Zhu, Hongtao; Yu, Jie; Claxton, Derek P; Yoder, Nate; Yoshioka, Craig; Gouaux, Eric (2018-07-25).
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immune responses and promote "regulatory" immune responses, such that GABA administration has been shown to inhibit
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Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT (August 2009). "Bioassay-guided fractionation of lemon balm (
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Marín O, Rubenstein JL (November 2001). "A long, remarkable journey: tangential migration in the telencephalon".
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Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review
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Kwakowsky A, Schwirtlich M, Zhang Q, Eisenstat DD, Erdélyi F, Baranyi M, Katarova ZD, Szabó G (December 2007).
2225:"Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA" 763: 8990: 6805: 6291: 2823:"GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition" 1330: 1756: 9834: 9397: 9313: 7155: 7130: 6770: 6645: 6264: 5984:
Park DH, Mirabella R, Bronstein PA, Preston GM, Haring MA, Lim CK, Collmer A, Schuurink RC (October 2010).
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In 1883, GABA was first synthesized, and it was first known only as a plant and microbe metabolic product.
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and adult stages. As the brain develops into adulthood, GABA's role changes from excitatory to inhibitory.
500: 361: 5379:"The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator" 2913:
Maric D, Liu QY, Maric I, Chaudry S, Chang YH, Smith SV, Sieghart W, Fritschy JM, Barker JL (April 2001).
8717: 6368: 1868: 521: 9901: 6704: 5071:"Neurosteroids — Endogenous Regulators of Seizure Susceptibility and Role in the Treatment of Epilepsy" 950: 722: 53: 1763: 1139:. The β-cells secrete GABA along with insulin and the GABA binds to GABA receptors on the neighboring 9729: 9107: 9097: 8523: 7467: 7223: 6910: 6841: 6228: 4917:
Dubrovsky BO (February 2005). "Steroids, neuroactive steroids and neurosteroids in psychopathology".
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Müller EE, Locatelli V, Cocchi D (April 1999). "Neuroendocrine control of growth hormone secretion".
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Chua HC, Chebib M (2017). "GABA a Receptors and the Diversity in their Structure and Pharmacology".
2774:"Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus" 9627: 7160: 5931:
Ramesh SA, Tyerman SD, Gilliham M, Xu B (2016). "γ-Aminobutyric acid (GABA) signalling in plants".
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Belelli D, Lambert JJ (July 2005). "Neurosteroids: endogenous regulators of the GABA(A) receptor".
4646: 3633:"Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis" 1924: 1624: 1253: 1069: 934: 538: 445: 251: 5665:
Singh YN, Singh NN (2002). "Therapeutic potential of kava in the treatment of anxiety disorders".
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Storer, R. James; Ferrante, Antonio (10 October 1997). "Radiochemical Assay of Diamine Oxidase".
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Chapouthier G, Venault P (October 2001). "A pharmacological link between epilepsy and anxiety?".
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Olsen RW, Betz H (2006). "GABA and glycine". In Siegel GJ, Albers RW, Brady S, Price DD (eds.).
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Ffrench-Constant RH, Rocheleau TA, Steichen JC, Chalmers AE (June 1993). "A point mutation in a
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Campagna JA, Miller KW, Forman SA (May 2003). "Mechanisms of actions of inhaled anesthetics".
3903: 2527: 1429:, although certain areas of the brain that have no effective blood–brain barrier, such as the 9389: 8339: 7268: 7185: 6800: 6660: 6650: 6573: 5428:"Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor" 2587: 2444:"The role and the mechanism of γ-aminobutyric acid during central nervous system development" 2194: 1592: 1371: 1213:
In 2018, GABA has shown to regulate secretion of a greater number of cytokines. In plasma of
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Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A (September 2006).
4638: 3533:"Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes" 2554: 1355:, but more current research describes the notion as being unclear pending further research. 1228:. The system is activated by exposure to allergens and may participate in the mechanisms of 9759: 9062: 8582: 8218: 7729: 7195: 7170: 6790: 6785: 6670: 6459: 6077: 5887: 5488: 5256: 5197: 5041: 4760: 4711: 4048: 3544: 3225: 3214:"GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes" 3167: 3108: 2346: 2295: 1434: 1399: 509: 183: 9691: 1116: 8: 9696: 9632: 9112: 9092: 8576: 8213: 7917: 7739: 7630: 6619: 6485: 6479: 6309: 4800:
Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S (December 2005).
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Mellon SH, Griffin LD (2002). "Neurosteroids: biochemistry and clinical significance".
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Schousboe A, Waagepetersen HS (2007). "GABA: Homeostatic and pharmacological aspects".
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are ligand-activated chloride channels: when activated by GABA, they allow the flow of
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Erdö SL, Wolff JR (February 1990). "γ-Aminobutyric acid outside the mammalian brain".
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GABAergic cells. In contrast, GABA exhibits both excitatory and inhibitory actions in
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Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S (2015).
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Besides the nervous system, GABA is also produced at relatively high levels in the
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receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB)".
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Foster AC, Kemp JA (February 2006). "Glutamate- and GABA-based CNS therapeutics".
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neurons, and have chiefly inhibitory action at receptors in the adult vertebrate.
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Proceedings of the National Academy of Sciences of the United States of America
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Krantis, Anthony (2000-12-01). "GABA in the Mammalian Enteric Nervous System".
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also contribute greatly to building up the GABAergic cortical cell population.
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Dimitrijevic N, Dzitoyeva S, Satta R, Imbesi M, Yildiz S, Manev H (2005). "
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The Glutamate/GABA-Glutamine Cycle: Amino Acid Neurotransmitter Homeostasis
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based on studies of mice). Many of the substances below are known to cause
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Vanlersberghe, C; Camu, F (2008). "Etomidate and Other Non-Barbiturates".
5061: 5012: 4448: 3424: 3187: 2964:"Excitatory actions of gaba during development: the nature of the nurture" 2891: 2807: 2701: 2553:
Purves D, Fitzpatrick D, Hall WC, Augustine GJ, Lamantia AS, eds. (2007).
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LoTurco JJ, Owens DF, Heath MJ, Davis MB, Kriegstein AR (December 1995).
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of tomatoes. Evidence also suggests a role in cell signalling in plants.
1686: 1605: 1588: 1556: 1540: 1523: 1411: 1333:
neurotransmitter) into GABA (the principal inhibitory neurotransmitter).
1221:
are increased and of those, 16 are inhibited by GABA in the cell assays.
1199: 899: 8273: 6223: 6170:"Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies" 4723: 3046:"GABA regulates stem cell proliferation before nervous system formation" 2772:
Behar TN, Schaffner AE, Scott CA, O'Connell C, Barker JL (August 1998).
2241: 1951:
GABA is also found in plants. It is the most abundant amino acid in the
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Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL (2013).
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if you can. Unsourced or poorly sourced material may be challenged and
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Historically it was thought that exogenous GABA did not penetrate the
1111:
mRNA expression of the embryonic variant of the GABA-producing enzyme
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GABAA Receptors and the Diversity in their Structure and Pharmacology
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The Brain, the Nervous System, and Their Diseases [3 volumes]
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Receptor Subunit Selectivity of Alcohol Actions". In Enna SJ (ed.).
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In 2007, an excitatory GABAergic system was described in the airway
1087:. GABA can influence the development of neural progenitor cells via 809:
Except where otherwise noted, data are given for materials in their
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enzymes catalyze the conversion of 4-aminobutanoic acid (GABA) and
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express receptors for GABA and administration of GABA can suppress
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In 1950, GABA was discovered as an integral part of the mammalian
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Progress in Neuro-Psychopharmacology & Biological Psychiatry
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Toraskar, Mrunmayee; Pratima R.P. Singh; Shashank Neve (2010).
1678: 1311: 1233: 1229: 1165: 986: 982: 877: 870: 294: 121: 5755:
L.) using an in vitro measure of GABA transaminase activity".
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Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors
100: 9087: 8737: 8463: 8313: 7929: 7545: 7109: 6915: 6589: 5983: 5300: 4641:
Basic Neurochemistry: Molecular, Cellular and Medical Aspects
3928: 3153: 1189: 1185: 1112: 1099:, causing cell cycle arrest in the S-phase, limiting growth. 994: 990: 484: 274: 240: 6208:
Clinical disorders known to affect inherited GABA metabolism
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Tian J, Lu Y, Zhang H, Chau CH, Dang HN, Kaufman DL (2004).
1025:
inside the cell changes the functional role of GABA between
526: 112: 9182: 8995: 8677: 8647: 8389: 8379: 8319: 8309: 8305: 7892: 5329: 5073:. In Noebels JL, Avoli M, Rogawski MA, et al. (eds.). 4746: 4370:
Oketch-Rabah HA, Madden EF, Roe AL, Betz JM (August 2021).
3876:
Molecular Orbital Calculations for Amino Acids and Peptides
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Popp A, Urbach A, Witte OW, Frahm C (2009). Reh TA (ed.).
2192: 1192:, albeit at much lower levels than in neurons or β-cells. 8097: 5845:. Vol. 79. New Jersey: Humana Press. p. 91–96. 4701: 4543:. Advances in Pharmacology. Vol. 79. pp. 1–34. 4369: 4321:
Powers ME, Yarrow JF, McCoy SC, Borst SE (January 2008).
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Marescaux, C.; Vergnes, M.; Bernasconi, R. (2013-03-08).
1927:
of GABA and can be converted into GABA by the actions of
1214: 164: 161: 141: 135: 124: 80: 77: 9666: 5750: 4990: 2336: 1252:
group deprotonated and the amino group protonated). Its
5930: 3682:"+ T Cells and Is Immunosuppressive in Type 1 Diabetes" 3211: 2723:
Haydar TF, Wang F, Schwartz ML, Rakic P (August 2000).
2722: 2381: 27:
Main inhibitory neurotransmitter in the mammalian brain
9019: 7477: 6167: 5797: 5186:: adult RNA interference and pharmacological evidence" 4461: 4320: 3993:
Gaba and the Basal Ganglia - from Molecules to Systems
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and muscle cells, and also the stimulation of certain
6168:
Parviz M, Vogel K, Gibson KM, Pearl PL (2014-11-25).
4581: 4462:
Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008).
4285: 4131:"The Metabolism and Functions of γ-Aminobutyric Acid" 3319: 3043: 969:
Neurons that produce GABA as their output are called
138: 127: 103: 5242: 4421:
Balemans MG, Mans D, Smith I, Van Benthem J (1983).
4247: 3897: 3895: 3679: 3483: 3092: 2912: 2588:"The role of GABA in the early neuronal development" 2561:(4th ed.). Sunderland, Mass: Sinauer. pp.  953:
that open or close ion channels via intermediaries (
167: 144: 118: 109: 9528:
Tooltip Vesicular inhibitory amino acid transporter
5873: 5622:"Sleep circuitry and the hypnotic mechanism of GABA 5584: 4799: 4663: 3630: 3488:receptors mediate inhibition of T cell responses". 2821:Ganguly K, Schinder AF, Wong ST, Poo M (May 2001). 2222: 2218: 2216: 413: 158: 132: 115: 97: 94: 83: 74: 5834: 4879: 4672: 4212: 3840: 3728: 3484:Tian J, Chau C, Hales TG, Kaufman DL (1999). "GABA 2525: 2067: 1495:receptor ligands are shown in the following table 1057:(acting on nearby cells) signalling mediator. The 7314: 6263: 5536:Acta Anaesthesiologica Scandinavica. Supplementum 5138: 4630: 3908:. Oxford : Oxford University Press. p. 106. 3892: 2546: 2526:Schousboe, Arne; Sonnewald, Ursula (2016-11-25). 1329:. This process converts glutamate (the principal 9873: 5477:"Absinthe and gamma-aminobutyric acid receptors" 3270: 2387: 2213: 1232:. GABAergic systems have also been found in the 566:InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) 472: 9612: 7334: 7258: 7118: 6124: 4587: 4534: 4532: 4530: 4528: 4526: 3901: 3589: 3479: 3477: 3207: 3205: 2630: 2585: 2286:GABA receptor confers insecticide resistance". 1530:, piperidine-4-sulfonic acid (partial agonist) 965:Release, Reuptake, and Metabolism Cycle of GABA 576:InChI=1/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) 226: 5840: 5588:Ullmann's Encyclopedia of Industrial Chemistry 4842: 3531:Mendu SK, Bhandage A, Jin Z, Birnir B (2012). 2437: 2435: 2013:Succinic semialdehyde dehydrogenase deficiency 1730:Please review the contents of the section and 997:. In mammals, some GABAergic neurons, such as 9897:GABAA receptor positive allosteric modulators 9359: 7438: 6712: 6249: 5533: 5180:Dzitoyeva S, Dimitrijevic N, Manev H (2003). 5068: 4953: 4281: 4279: 3445: 1374:and glutamate. Succinic semialdehyde is then 1239: 7452: 6395: 6057: 6022: 5924: 5867: 5791: 5744: 5701: 5658: 5291: 5173: 4523: 4363: 4241: 4206: 4171: 3984: 3941: 3846: 3624: 3583: 3524: 3474: 3354: 3313: 3264: 3202: 3086: 3037: 3002: 2955: 2906: 2814: 2716: 2624: 2579: 2484: 1150:(which would counteract insulin's effects). 1115:in a coronal brain section of a one-day-old 1102: 692:247.9 °C (478.2 °F; 521.0 K) 682:203.7 °C (398.7 °F; 476.8 K) 9375: 7454: 6028: 5236: 5075:Jasper's Basic Mechanisms of the Epilepsies 4802:"Neurosteroid access to the GABAA receptor" 4414: 4327:Medicine and Science in Sports and Exercise 3631:Tian J, Yong J, Dang H, Kaufman DL (2011). 3396: 3147: 2863: 2765: 2667: 2432: 2330: 2103: 1146:(α-cells) and inhibits them from secreting 1064:GABA regulates the proliferation of neural 9366: 9352: 8702:Tooltip γ-Aminobutyric acid A-rho receptor 7445: 7431: 7251: 6719: 6705: 6256: 6242: 5664: 4538: 4314: 4276: 4177: 4122: 3905:The Biochemical Basis of Neuropharmacology 3772: 3766: 3722: 3044:Wang DD, Kriegstein AR, Ben-Ari Y (2008). 2275: 2099: 2097: 2095: 541: 364: 322: 9860:Glutamate metabolism/transport modulators 7368: 6193: 6150: 6097: 6005: 5952: 5907: 5641: 5510: 5500: 5451: 5402: 5219: 5209: 4916: 4825: 4782: 4772: 4636: 4605: 4479: 4438: 4397: 4387: 4338: 4154: 4128: 3815: 3791: 3705: 3656: 3607: 3566: 3556: 3402: 3379: 3337: 3296: 3247: 3237: 3130: 3120: 3069: 2938: 2838: 2797: 2748: 2691: 2467: 2258: 2240: 2199:. Springer Science & Business Media. 2169: 2159: 508: 9912:Biology of obsessive–compulsive disorder 9760:Valproate semisodium (divalproex sodium) 9671:Tooltip γ-Aminobutyrate aminotransferase 9407: 5474: 3849:Journal of Molecular Structure: THEOCHEM 1677:contains GABAergic compounds, including 1297: 1106: 960: 6127:"A half century of γ-aminobutyric acid" 6063: 5619: 4502: 4034: 3947: 2961: 2092: 1467:Although in chemical terms, GABA is an 537: 450: 342: 14: 9874: 9027:Tooltip γ-Aminobutyric acid B receptor 7485:Tooltip γ-Aminobutyric acid A receptor 5376: 5297:Source unclear. One of the following: 4956:Trends in Endocrinology and Metabolism 4049:10.1152/physiologyonline.2000.15.6.284 1091:(BDNF) expression. GABA activates the 355: 9347: 7426: 6726: 6700: 6237: 4588:Löscher, W.; Rogawski, M. A. (2012). 4468:The Journal of Physiological Sciences 4030: 4028: 3902:Roth RJ, Cooper JR, Bloom FE (2003). 3873: 3775:The Leydig cell in health and disease 2071:CRC Handbook of Chemistry and Physics 569:Key: BTCSSZJGUNDROE-UHFFFAOYSA-N 302: 282: 9332:GABA metabolism/transport modulators 6224:List of GABA neurons on NeuroLex.org 4427:Reproduction, Nutrition, Development 4129:Bown AW, Shelp BJ (September 1997). 2592:GABA in Autism and Related Disorders 2441: 2137: 2135: 2061: 1807:Other GABAergic modulators include: 1699: 1601:Orthosteric (competitive) Antagonist 1425:In general, GABA does not cross the 1302:GABAergic neurons which produce GABA 1032: 977:are a typical example of inhibitory 9448:Deramciclane (EGIS-3886, EGYT-3886) 7728:Positive modulators (abridged; see 6214:Gamma-aminobutyric acid MS Spectrum 5578: 4645:(7th ed.). Elsevier. pp.  4503:Hellier, Jennifer L. (2014-12-16). 1384:succinic semialdehyde dehydrogenase 1306:GABA is primarily synthesized from 1262:extended, are found as a result of 933:in which the receptor is part of a 914: 579:Key: BTCSSZJGUNDROE-UHFFFAOYAC 463: 433: 24: 5630:Journal of Clinical Sleep Medicine 5548:10.1111/j.1399-6576.1995.tb04374.x 5444:10.1523/jneurosci.17-02-00625.1997 4092:10.1016/j.neuroscience.2007.01.062 4025: 3417:10.1111/j.1471-4159.1990.tb01882.x 2931:10.1523/JNEUROSCI.21-07-02343.2001 2790:10.1523/JNEUROSCI.18-16-06378.1998 2741:10.1523/JNEUROSCI.20-15-05764.2000 1486: 1336:GABA can also be synthesized from 1079:GABA also regulates the growth of 25: 9938: 9263:Homotaurine (tramiprosate, 3-APS) 8761:-Chloroacetylcytosine arabinoside 7556:Homotaurine (tramiprosate, 3-APS) 6118: 2132: 2042:Template:GABA receptor modulators 1119:, with the highest expression in 1089:brain-derived neurotrophic factor 876:. Its principal role is reducing 6125:Smart TG, Stephenson FA (2019). 6007:10.1111/j.1365-313X.2010.04327.x 5679:10.2165/00023210-200216110-00002 5395:10.1016/j.neuropharm.2008.06.004 4687:10.1016/j.pharmthera.2007.03.007 3062:10.1111/j.1535-7511.2008.00270.x 2068:Haynes, William M., ed. (2016). 1796: 1704: 817: 803:12,680 mg/kg (mouse, oral) 633: 627: 154: 70: 52: 43: 9617:Tooltip Glutamate decarboxylase 8555:Pentylenetetrazol (pentetrazol) 5977: 5613: 5527: 5468: 5419: 5370: 5132: 5092: 4675:Pharmacology & Therapeutics 4496: 4455: 4071: 3922: 3867: 3673: 3439: 2519: 2030: 1483:as are many alpha-amino acids. 1393: 1293: 1076:and the formation of synapses. 989:activation at synapses between 813:(at 25 °C , 100 kPa). 6965:Norepinephrine (noradrenaline) 5108:Deccan Journal of Pharmacology 5069:Reddy DS, Rogawski MA (2012). 4818:10.1523/JNEUROSCI.4173-05.2005 3158:-receptor chloride channels". 2586:Jelitai M, Madarasz E (2005). 2186: 1972:(GABA-transaminase) deficiency 1732:add the appropriate references 1666:, which then acts via the GABA 1638:Negative allosteric modulators 1591:, and anaesthetics (including 1536:Positive allosteric modulators 1390:as a usable source of energy. 1053:(acting on the same cell) and 869:in the developmentally mature 764:Occupational safety and health 662:white microcrystalline powder 636: 621: 13: 1: 9927:Non-proteinogenic amino acids 9835:Receptor/signaling modulators 9314:Receptor/signaling modulators 8469:Isopregnanolone (sepranolone) 6265:Non-proteinogenic amino acids 6174:Journal of Pediatric Epilepsy 6064:Roberts MR (September 2007). 6043:10.1016/j.tplants.2004.01.006 5620:Lu, J.; Greco, M. A. (2006). 5597:10.1002/14356007.a06_527.pub2 5344:10.1016/S1054-3589(06)54008-6 5101:"STUDY OF GABAERGIC AGONISTS" 4968:10.1016/S1043-2760(01)00503-3 4300:10.1152/physrev.1999.79.2.511 4227:10.1016/S0165-6147(00)01807-1 4001:10.1016/S0079-6123(06)60002-2 3502:10.1016/s0165-5728(98)00264-1 2840:10.1016/S0092-8674(01)00341-5 2600:10.1016/S0074-7742(05)71002-3 2054: 1358: 9917:Peripherally selective drugs 9853:receptor positive modulators 9325:receptor positive modulators 7833:ergoloid (dihydroergotoxine) 6219:Scholarpedia article on GABA 5812:10.1016/j.neulet.2011.01.072 5730:10.1016/j.ejphar.2005.07.016 5481:Proc. Natl. Acad. Sci. U.S.A 5190:Proc. Natl. Acad. Sci. U.S.A 5149:10.1007/978-3-540-74806-9_13 5005:10.1016/0896-6273(90)90202-Q 4845:Nature Reviews. Neuroscience 4340:10.1249/mss.0b013e318158b518 3861:10.1016/0166-1280(88)80084-8 3649:10.3109/08916934.2011.571223 3558:10.1371/journal.pone.0042959 3218:Proc. Natl. Acad. Sci. U.S.A 3122:10.1371/journal.pone.0004371 2962:Ben-Ari Y (September 2002). 2884:10.1016/0304-3940(93)90505-F 2693:10.1016/0896-6273(95)90008-X 2118:10.1016/0028-3908(71)90013-X 1991:Giant depolarizing potential 1970:4-aminobutyrate transaminase 1946: 1869:GABA transaminase inhibitors 1658:GABAergic pro-drugs include 1475:, refers specifically to an 1462: 1406:(known as GABA analogues or 880:excitability throughout the 7: 9380:Tooltip γ-Aminobutyric acid 6558:List of abiotic amino acids 6369:Azetidine-2-carboxylic acid 5990:reduce bacterial virulence" 5432:The Journal of Neuroscience 4931:10.1016/j.pnpbp.2004.11.001 4806:The Journal of Neuroscience 4549:10.1016/bs.apha.2017.03.003 4481:10.2170/physiolsci.rp006208 3773:Payne AH, Hardy MH (2007). 3698:10.1016/j.ebiom.2018.03.019 3609:10.4049/jimmunol.173.8.5298 2390:Nature Reviews Neuroscience 1958: 1717:reliable medical references 951:G protein-coupled receptors 909: 785:or concentration (LD, LC): 10: 9943: 8524:Nonsteroidal antiandrogens 5377:Fisher JL (January 2009). 5114:(2): 56–69. Archived from 4192:10.1016/j.coph.2005.11.005 3381:10.1016/j.cell.2016.11.002 2505:10.1152/physrev.00017.2006 2402:10.1038/s41583-023-00724-7 1662:, which is metabolised to 1270: 1244:GABA is found mostly as a 1240:Structure and conformation 1210:in several animal models. 29: 9907:Glycine receptor agonists 9826: 9804: 9797: 9682:3-Hydrazinopropionic acid 9664: 9610: 9601: 9521: 9405: 9396: 9305: 9008: 8691: 7475: 7466: 7307: 7295: 7241: 7218: 7209: 7108: 7085: 7076: 7056: 6978: 6937: 6928: 6901: 6850: 6824: 6771:Glutamic acid (glutamate) 6766:Aspartic acid (aspartate) 6753: 6744: 6734: 6634: 6582: 6566: 6550: 6472: 6450: 6422: 6382: 6343: 6318: 6290: 6271: 5945:10.1007/s00018-016-2415-7 5315:10.1016/j.bcp.2004.07.023 4894:10.1007/s00213-005-0213-2 3460:10.1016/j.lfs.2015.12.041 3023:10.1152/jn.2002.88.2.1005 2460:10.1007/s12264-008-0109-3 1723:or relies too heavily on 1103:Beyond the nervous system 807: 781: 761: 756: 608: 588: 553: 210: 194: 182: 60: 51: 42: 9842:GABA receptor modulators 9628:3-Mercaptopropionic acid 9412:Tooltip GABA transporter 8073:sulfonmethane (sulfonal) 6955:Epinephrine (adrenaline) 6143:10.1177/2398212819858249 5851:10.1385/0-89603-448-8:91 5303:Biochemical Pharmacology 5247:and glycine receptors". 3962:10.1177/1073858402238515 2442:Li K, Xu E (June 2008). 2161:10.3389/fpsyg.2015.01520 2023: 1851:GABA reuptake inhibitors 1627:(e.g., channel blocker) 1625:Uncompetitive antagonist 935:ligand-gated ion channel 6328:gamma-Aminobutyric acid 5591:. Weinheim: Wiley-VCH. 5475:Olsen RW (April 2000). 5211:10.1073/pnas.0830111100 5054:10.1126/science.2422758 4774:10.1073/pnas.0606544103 3239:10.1073/pnas.1102715108 2359:10.1126/science.1121325 1431:periventricular nucleus 1386:and as such enters the 1370:(α-ketoglutarate) into 1315:glutamate decarboxylase 1217:patients, levels of 26 919:Two general classes of 856:gamma Aminobutyric acid 452:gamma-Aminobutyric+Acid 18:Gamma-aminobutyric acid 9892:GABA receptor agonists 9882:Inhibitory amino acids 8952:5α-Dihydroprogesterone 8499:Morphine-3-glucuronide 8159:Hyenachin (mellitoxin) 8044:Retigabine (ezogabine) 7390:Carbonyl sulfide (COS) 6991:N-Methylphenethylamine 6567:Engineered amino acids 6510:Dihydroxyphenylglycine 6432:2-Aminoisobutyric acid 5502:10.1073/pnas.97.9.4417 2046:GABAA receptor#Ligands 2040:ligands are listed at 1965:3-Aminoisobutyric acid 1941:metabolic intermediate 1933:aldehyde dehydrogenase 1563:(i.e., z-drugs, e.g., 1346:aldehyde dehydrogenase 1303: 1280:central nervous system 1124: 979:central nervous system 966: 947:metabotropic receptors 874:central nervous system 8340:Chlorophenylsilatrane 7131:2-AGE (noladin ether) 6574:Expanded genetic code 4215:Trends Pharmacol. Sci 1925:biochemical precursor 1593:volatile anaesthetics 1400:allosteric modulators 1372:succinic semialdehyde 1301: 1236:and in the eye lens. 1110: 1022:electrical resistance 964: 32:Gaba (disambiguation) 9290:Negative modulators: 9170:Positive modulators: 9063:Arbaclofen placarbil 8949:Negative modulators: 8798:Positive modulators: 8583:Pregnenolone sulfate 8219:17-Phenylandrostenol 8201:Negative modulators: 8086:constituents (e.g., 8056:constituents (e.g., 7918:Neuroactive steroids 7895:constituents (e.g., 7631:Neuroactive steroids 7342:Carbon monoxide (CO) 6460:Carboxyglutamic acid 6137:: 2398212819858249. 6090:10.4161/psb.2.5.4335 5988:Pseudomonas syringae 5800:Neuroscience Letters 4440:10.1051/rnd:19830114 4262:10.1056/NEJMra021261 1998:, a GABA deficiency 1937:γ-aminobutyraldehyde 1549:neuroactive steroids 1512:Orthosteric Agonist 1435:human growth hormone 1321:(the active form of 1068:, the migration and 1059:ganglionic eminences 201:3-Carboxypropylamine 197:γ-Aminobutanoic acid 188:4-Aminobutanoic acid 184:Preferred IUPAC name 38:γ-Aminobutyric acid 30:For other uses, see 9549:Chicago sky blue 6B 9423:4-Aminovaleric acid 8879:Gabazine (SR-95531) 8869:CGP-36742 (SGS-742) 8577:dihydropicrotoxinin 8302:Bicyclic phosphates 8214:11-Ketoprogesterone 8149:Gabazine (SR-95531) 7974:pyrazolopyrimidines 7347:Hydrogen sulfide (H 7201:Virodhamine (O-AEA) 6620:Aminolevulinic acid 6551:Abiotic amino acids 6486:Aminolevulinic acid 6480:4-Aminobenzoic acid 6310:Diaminopimelic acid 6292:bacterial cell wall 6082:2007PlSiB...2..408R 5933:Cell. Mol. Life Sci 5892:2015NatCo...6.7879R 5843:Polyamine Protocols 5753:Melissa officinalis 5493:2000PNAS...97.4417O 5261:1997Natur.389..385M 5202:2003PNAS..100.5485D 5046:1986Sci...232.1004D 4765:2006PNAS..10314602A 4724:10.1038/nature05324 4716:2006Natur.444..486H 4180:Curr Opin Pharmacol 3549:2012PLoSO...742959M 3230:2011PNAS..10811692S 3172:1989Natur.341..233R 3113:2009PLoSO...4.4371P 2351:2006Sci...311..233S 2300:1993Natur.363..449F 2242:10.7554/eLife.39383 1893:Melissa officinalis 1518:, GABA, gaboxadol ( 1427:blood–brain barrier 1416:anterograde amnesia 1353:blood–brain barrier 1319:pyridoxal phosphate 1208:autoimmune diseases 1121:subventricular zone 1018:Shunting inhibition 893:blood–brain barrier 860:γ-Aminobutyric acid 699:Solubility in water 654: g·mol 264:Beilstein Reference 199:4-Aminobutyric acid 39: 8400:FG-7142 (ZK-31906) 7946:Nonbenzodiazepines 7404:Sulfur dioxide (SO 7315:Cholinergic system 7017:Phenylethanolamine 6996:N-Methyltryptamine 6960:NAS (normelatonin) 6747:inhibitory systems 6745:Major excitatory / 6686:Dehydroamino acids 6646:Encoded (proteins) 6131:Brain Neurosci Adv 6070:Plant Signal Behav 5900:10.1038/ncomms8879 5643:10.5664/jcsm.26527 5141:Modern Anesthetics 4882:Psychopharmacology 4389:10.3390/nu13082742 4147:10.1104/pp.115.1.1 3817:10.1002/dvdy.21361 3374:(1–2): 73–85.e11. 2968:Nat. Rev. Neurosci 2633:Nat. Rev. Neurosci 1929:aldehyde reductase 1815:receptor ligands. 1691:dihydromethysticin 1561:nonbenzodiazepines 1455:(the precursor of 1440:GABA enhances the 1420:retrograde amnesia 1398:Drugs that act as 1304: 1125: 1072:the elongation of 975:Medium spiny cells 967: 889:dietary supplement 887:GABA is sold as a 840:Infobox references 777:Irritant, Harmful 738:4.031 (carboxyl; H 37: 9902:Gamma-Amino acids 9869: 9868: 9822: 9821: 9793: 9792: 9755:Valproate pivoxil 9719: 9692:γ-Acetylenic-GABA 9597: 9596: 9341: 9340: 9301: 9300: 9223:2-Hydroxysaclofen 9004: 9003: 8894:Isonipecotic acid 8259:Anabolic steroids 8229:α5IA (LS-193,268) 8139:Dihydrosecurinine 8024:Pyrazolopyridines 7793:potassium bromide 7791:compounds (e.g., 7754:Anabolic steroids 7732:for a full list): 7586:Isonipecotic acid 7420: 7419: 7416: 7415: 7364: 7363: 7356:Nitric oxide (NO) 7330: 7329: 7303: 7291: 7290: 7287: 7286: 7237: 7236: 7233: 7232: 7104: 7103: 7100: 7099: 7072: 7071: 6986:3-Iodothyronamine 6924: 6923: 6728:Neurotransmitters 6694: 6693: 6656:Non-proteinogenic 6615: 6614: 6594:citric acid cycle 6546: 6545: 6468: 6467: 6446: 6445: 6418: 6417: 6354:ADDA (amino acid) 6320:neurotransmitters 6186:10.3233/PEP-14097 5860:978-0-89603-448-8 5718:Eur. J. Pharmacol 5383:Neuropharmacology 5353:978-0-12-032957-1 5255:(6649): 385–389. 5158:978-3-540-72813-9 4656:978-0-12-088397-4 4607:10.1111/epi.12025 4516:978-1-61069-338-7 4010:978-0-444-52184-2 3915:978-0-19-514008-8 3885:978-0-8176-3893-1 3874:Sapse AM (2000). 3784:978-1-58829-754-9 3339:10.2337/db14-0153 3289:10.2337/db13-0931 2572:978-0-87893-697-7 2539:978-3-319-45096-4 2345:(5758): 233–235. 2206:978-3-7091-9206-1 2106:Neuropharmacology 2078:. pp. 5–88. 2074:(97th ed.). 1921:4-Amino-1-butanol 1805: 1804: 1781: 1656: 1655: 1388:citric acid cycle 1364:GABA transaminase 1259:quantum chemistry 1135:(β-cells) of the 1085:neural stem cells 1033:Brain development 848:Chemical compound 846: 845: 522:CompTox Dashboard 252:Interactive image 16:(Redirected from 9934: 9802: 9801: 9745:Sodium valproate 9717: 9672: 9668: 9640: 9618: 9614: 9608: 9607: 9529: 9525: 9413: 9409: 9403: 9402: 9381: 9377: 9368: 9361: 9354: 9345: 9344: 9048:4-Fluorophenibut 9028: 9024: 9015: 9014: 8884:Gaboxadol (THIP) 8801:Allopregnanolone 8703: 8699: 8434:Fluoroquinolones 8189:Thiocolchicoside 8009:Piperidinediones 7966:imidazopyridines 7922:allopregnanolone 7829:Dihydroergolines 7744:drinking alcohol 7635:allopregnanolone 7551:Gaboxadol (THIP) 7486: 7482: 7473: 7472: 7456: 7447: 7440: 7433: 7424: 7423: 7395:Nitrous oxide (N 7366: 7365: 7335:Gasotransmitters 7332: 7331: 7312: 7311: 7302: 7256: 7255: 7249: 7248: 7216: 7215: 7151:Anandamide (AEA) 7119:Endocannabinoids 7116: 7115: 7083: 7082: 6970:Serotonin (5-HT) 6935: 6934: 6754:Glutamate system 6751: 6750: 6742: 6741: 6721: 6714: 6707: 6698: 6697: 6587: 6586: 6470: 6469: 6452:clotting factors 6448: 6447: 6420: 6419: 6393: 6392: 6258: 6251: 6244: 6235: 6234: 6210: 6197: 6164: 6154: 6112: 6111: 6101: 6061: 6055: 6054: 6031:Trends Plant Sci 6026: 6020: 6019: 6009: 5981: 5975: 5974: 5956: 5939:(9): 1577–1603. 5928: 5922: 5921: 5911: 5871: 5865: 5864: 5838: 5832: 5831: 5795: 5789: 5788: 5769:10.1002/ptr.2712 5748: 5742: 5741: 5705: 5699: 5698: 5662: 5656: 5655: 5645: 5617: 5611: 5610: 5582: 5576: 5575: 5531: 5525: 5524: 5514: 5504: 5472: 5466: 5465: 5455: 5423: 5417: 5416: 5406: 5374: 5368: 5365: 5326: 5309:(8): 1581–1602. 5295: 5289: 5288: 5240: 5234: 5233: 5223: 5213: 5196:(9): 5485–5490. 5177: 5171: 5170: 5136: 5130: 5129: 5127: 5126: 5120: 5105: 5096: 5090: 5086: 5065: 5040:(4753): 1004–7. 5024: 4987: 4950: 4913: 4876: 4839: 4829: 4812:(50): 11605–13. 4796: 4786: 4776: 4743: 4698: 4667: 4661: 4660: 4644: 4634: 4628: 4627: 4609: 4585: 4579: 4578: 4536: 4521: 4520: 4500: 4494: 4493: 4483: 4459: 4453: 4452: 4442: 4418: 4412: 4411: 4401: 4391: 4367: 4361: 4360: 4342: 4318: 4312: 4311: 4283: 4274: 4273: 4245: 4239: 4238: 4210: 4204: 4203: 4175: 4169: 4168: 4158: 4126: 4120: 4119: 4075: 4069: 4068: 4032: 4023: 4022: 3988: 3982: 3981: 3945: 3939: 3938: 3926: 3920: 3919: 3899: 3890: 3889: 3871: 3865: 3864: 3844: 3838: 3837: 3819: 3795: 3789: 3788: 3777:. Humana Press. 3770: 3764: 3763: 3726: 3720: 3719: 3709: 3677: 3671: 3670: 3660: 3628: 3622: 3621: 3611: 3587: 3581: 3580: 3570: 3560: 3528: 3522: 3521: 3481: 3472: 3471: 3443: 3437: 3436: 3400: 3394: 3393: 3383: 3358: 3352: 3351: 3341: 3332:(12): 4197–205. 3317: 3311: 3310: 3300: 3268: 3262: 3261: 3251: 3241: 3209: 3200: 3199: 3180:10.1038/341233a0 3151: 3145: 3144: 3134: 3124: 3090: 3084: 3083: 3073: 3041: 3035: 3034: 3006: 3000: 2999: 2959: 2953: 2952: 2942: 2910: 2904: 2903: 2878:(1–2): 150–154. 2867: 2861: 2860: 2842: 2818: 2812: 2811: 2801: 2769: 2763: 2762: 2752: 2720: 2714: 2713: 2695: 2686:(6): 1287–1298. 2671: 2665: 2664: 2645:10.1038/35097509 2628: 2622: 2621: 2583: 2577: 2576: 2560: 2550: 2544: 2543: 2523: 2517: 2516: 2499:(4): 1215–1284. 2488: 2482: 2481: 2471: 2439: 2430: 2429: 2385: 2379: 2378: 2334: 2328: 2327: 2308:10.1038/363449a0 2294:(6428): 449–51. 2279: 2273: 2272: 2262: 2244: 2220: 2211: 2210: 2190: 2184: 2183: 2173: 2163: 2139: 2130: 2129: 2101: 2090: 2089: 2065: 2048: 2034: 1996:Spastic diplegia 1800: 1799: 1791: 1788: 1782: 1780: 1739: 1708: 1707: 1700: 1664:trichloroethanol 1501:Activity at GABA 1498: 1497: 1477:alpha amino acid 1453:-acetylserotonin 1248:(i.e., with the 1066:progenitor cells 999:chandelier cells 915:Neurotransmitter 902:form of GABA is 867:neurotransmitter 830: 824: 821: 820: 745:10.556 (amino; H 653: 638: 635: 629: 623: 616:Chemical formula 546: 545: 530: 528: 512: 476: 465: 454: 437: 417: 393:Gmelin Reference 376: 368: 357: 346: 326: 306: 286: 254: 230: 205:Piperidinic acid 177: 176: 173: 172: 169: 166: 163: 160: 151: 150: 147: 146: 143: 140: 137: 134: 130: 129: 126: 123: 120: 117: 114: 111: 108: 105: 102: 99: 96: 93: 89: 88: 85: 82: 79: 76: 56: 47: 40: 36: 21: 9942: 9941: 9937: 9936: 9935: 9933: 9932: 9931: 9872: 9871: 9870: 9865: 9852: 9818: 9789: 9735:Rosmarinic acid 9670: 9660: 9638: 9616: 9593: 9527: 9517: 9411: 9392: 9379: 9372: 9342: 9337: 9324: 9297: 9026: 9023: 9000: 8728:Homohypotaurine 8701: 8697: 8687: 8560:Phenylsilatrane 8102:chloral hydrate 8069:Sulfonylalkanes 7958:cyclopyrrolones 7779:Benzodiazepines 7531:Dihydromuscimol 7484: 7481: 7462: 7451: 7421: 7412: 7407: 7398: 7384: 7360: 7350: 7326: 7283: 7229: 7205: 7096: 7068: 7052: 6974: 6930:Biogenic amines 6920: 6897: 6846: 6820: 6746: 6730: 6725: 6695: 6690: 6689: 6671:Secondary amino 6630: 6611: 6578: 6562: 6542: 6464: 6442: 6414: 6378: 6374:Quisqualic acid 6339: 6334:Quisqualic acid 6314: 6286: 6267: 6262: 6121: 6116: 6115: 6062: 6058: 6027: 6023: 5982: 5978: 5929: 5925: 5872: 5868: 5861: 5839: 5835: 5796: 5792: 5749: 5745: 5715: 5706: 5702: 5663: 5659: 5625: 5618: 5614: 5607: 5583: 5579: 5532: 5528: 5473: 5469: 5424: 5420: 5375: 5371: 5354: 5333: 5296: 5292: 5246: 5241: 5237: 5178: 5174: 5159: 5137: 5133: 5124: 5122: 5118: 5103: 5097: 5093: 5089: 4857:10.1038/nrn1703 4759:(39): 14602–7. 4710:(7118): 486–9. 4668: 4664: 4657: 4635: 4631: 4586: 4582: 4559: 4537: 4524: 4517: 4501: 4497: 4460: 4456: 4419: 4415: 4368: 4364: 4319: 4315: 4284: 4277: 4256:(21): 2110–24. 4250:N. Engl. J. Med 4246: 4242: 4211: 4207: 4176: 4172: 4127: 4123: 4076: 4072: 4033: 4026: 4011: 3989: 3985: 3946: 3942: 3927: 3923: 3916: 3900: 3893: 3886: 3872: 3868: 3845: 3841: 3810:(12): 3532–44. 3796: 3792: 3785: 3771: 3767: 3727: 3723: 3678: 3674: 3629: 3625: 3602:(8): 5298–304. 3588: 3584: 3529: 3525: 3490:J. Neuroimmunol 3487: 3482: 3475: 3444: 3440: 3401: 3397: 3359: 3355: 3318: 3314: 3269: 3265: 3224:(28): 11692–7. 3210: 3203: 3166:(6239): 233–6. 3157: 3152: 3148: 3091: 3087: 3042: 3038: 3011:J. Neurophysiol 3007: 3003: 2960: 2956: 2911: 2907: 2868: 2864: 2819: 2815: 2784:(16): 6378–87. 2770: 2766: 2735:(15): 5764–74. 2721: 2717: 2672: 2668: 2629: 2625: 2610: 2584: 2580: 2573: 2551: 2547: 2540: 2524: 2520: 2489: 2485: 2440: 2433: 2386: 2382: 2335: 2331: 2280: 2276: 2221: 2214: 2207: 2191: 2187: 2140: 2133: 2102: 2093: 2086: 2066: 2062: 2057: 2052: 2051: 2039: 2035: 2031: 2026: 1961: 1949: 1814: 1801: 1797: 1792: 1786: 1783: 1740: 1729: 1725:primary sources 1709: 1705: 1669: 1660:chloral hydrate 1545:benzodiazepines 1504: 1494: 1489: 1487:GABAergic drugs 1465: 1396: 1361: 1342:diamine oxidase 1296: 1273: 1242: 1182:urinary bladder 1162:fallopian tubes 1105: 1096: 1070:differentiation 1035: 1008: 944: 931: 917: 912: 904:γ-aminobutyrate 862:) is the chief 849: 842: 837: 836: 835:  ?) 826: 822: 818: 814: 800: 794: 774: 752: 748: 741: 731: 701: 672:1.11 g/mL 651: 641: 632: 626: 618: 604: 601: 596: 595: 584: 581: 580: 577: 571: 570: 567: 561: 560: 549: 531: 524: 515: 495: 479: 466: 440: 420: 407: 395: 386: 349: 329: 309: 289: 266: 257: 244: 233: 220: 206: 204: 202: 200: 198: 190: 189: 157: 153: 131: 90: 73: 69: 35: 28: 23: 22: 15: 12: 11: 5: 9940: 9930: 9929: 9924: 9919: 9914: 9909: 9904: 9899: 9894: 9889: 9887:GABA analogues 9884: 9867: 9866: 9864: 9863: 9856: 9850: 9845: 9838: 9831: 9827: 9824: 9823: 9820: 9819: 9817: 9816: 9810: 9808: 9806:Antivitamin B6 9799: 9795: 9794: 9791: 9790: 9788: 9787: 9778: 9777: 9772: 9767: 9762: 9757: 9752: 9747: 9742: 9732: 9727: 9722: 9714: 9709: 9704: 9699: 9694: 9689: 9684: 9675: 9673: 9662: 9661: 9659: 9658: 9649: 9648: 9643: 9635: 9630: 9621: 9619: 9605: 9599: 9598: 9595: 9594: 9592: 9591: 9586: 9581: 9579:Nipecotic acid 9576: 9571: 9569:N-Butyric acid 9566: 9561: 9556: 9551: 9546: 9544:Bafilomycin A1 9541: 9532: 9530: 9519: 9518: 9516: 9515: 9510: 9505: 9500: 9495: 9490: 9485: 9480: 9478:Nipecotic acid 9475: 9470: 9465: 9460: 9455: 9450: 9445: 9440: 9435: 9430: 9425: 9416: 9414: 9400: 9394: 9393: 9371: 9370: 9363: 9356: 9348: 9339: 9338: 9336: 9335: 9328: 9322: 9317: 9310: 9306: 9303: 9302: 9299: 9298: 9296: 9295: 9286: 9285: 9280: 9275: 9270: 9265: 9260: 9255: 9250: 9245: 9240: 9235: 9230: 9225: 9216: 9215: 9210: 9205: 9200: 9195: 9190: 9185: 9180: 9175: 9166: 9165: 9160: 9155: 9150: 9145: 9143:Sodium oxybate 9140: 9135: 9130: 9125: 9120: 9115: 9110: 9105: 9100: 9095: 9090: 9085: 9080: 9075: 9070: 9065: 9060: 9055: 9050: 9045: 9040: 9038:1,4-Butanediol 9031: 9029: 9021: 9012: 9006: 9005: 9002: 9001: 8999: 8998: 8993: 8988: 8983: 8978: 8964: 8959: 8954: 8945: 8944: 8939: 8931: 8926: 8921: 8916: 8911: 8906: 8901: 8896: 8891: 8886: 8881: 8876: 8871: 8866: 8858: 8853: 8848: 8843: 8838: 8833: 8828: 8819: 8818: 8813: 8808: 8803: 8794: 8793: 8788: 8783: 8778: 8773: 8768: 8763: 8755: 8750: 8745: 8740: 8735: 8730: 8725: 8720: 8715: 8706: 8704: 8695: 8689: 8688: 8686: 8685: 8680: 8675: 8670: 8665: 8660: 8655: 8650: 8645: 8640: 8635: 8630: 8625: 8620: 8615: 8610: 8605: 8600: 8595: 8590: 8585: 8580: 8562: 8557: 8552: 8547: 8521: 8516: 8511: 8506: 8501: 8496: 8491: 8486: 8481: 8476: 8471: 8466: 8461: 8456: 8451: 8446: 8441: 8431: 8426: 8412: 8402: 8397: 8392: 8387: 8382: 8377: 8372: 8367: 8362: 8357: 8352: 8347: 8342: 8337: 8332: 8327: 8322: 8317: 8299: 8294: 8289: 8282:cephalosporins 8271: 8266: 8261: 8256: 8251: 8246: 8241: 8236: 8231: 8226: 8221: 8216: 8211: 8206: 8197: 8196: 8191: 8186: 8181: 8176: 8171: 8166: 8161: 8156: 8151: 8146: 8141: 8136: 8131: 8122: 8121: 8091: 8088:valerenic acid 8081: 8076: 8066: 8061: 8051: 8046: 8041: 8034:Quinazolinones 8031: 8021: 8016: 8006: 8001: 7991: 7986: 7981: 7943: 7938: 7933: 7915: 7910: 7905: 7900: 7890: 7880: 7875: 7870: 7856: 7853:mefenamic acid 7846: 7841: 7836: 7826: 7821: 7816: 7811: 7806: 7796: 7786: 7776: 7766: 7756: 7751: 7737: 7724: 7723: 7718: 7713: 7708: 7698: 7693: 7688: 7683: 7678: 7673: 7668: 7663: 7658: 7653: 7648: 7643: 7638: 7628: 7623: 7618: 7613: 7608: 7598: 7593: 7588: 7583: 7578: 7573: 7568: 7563: 7558: 7553: 7548: 7543: 7538: 7533: 7528: 7523: 7518: 7513: 7503: 7498: 7489: 7487: 7479: 7470: 7464: 7463: 7450: 7449: 7442: 7435: 7427: 7418: 7417: 7414: 7413: 7411: 7410: 7405: 7401: 7396: 7392: 7387: 7382: 7378: 7372: 7370: 7362: 7361: 7359: 7358: 7353: 7348: 7344: 7338: 7336: 7328: 7327: 7325: 7324: 7318: 7316: 7309: 7305: 7304: 7300: 7293: 7292: 7289: 7288: 7285: 7284: 7282: 7281: 7276: 7271: 7265: 7263: 7253: 7246: 7239: 7238: 7235: 7234: 7231: 7230: 7228: 7227: 7219: 7213: 7207: 7206: 7204: 7203: 7198: 7193: 7188: 7183: 7178: 7173: 7168: 7163: 7158: 7153: 7148: 7143: 7138: 7133: 7128: 7122: 7120: 7113: 7106: 7105: 7102: 7101: 7098: 7097: 7095: 7094: 7086: 7080: 7074: 7073: 7070: 7069: 7067: 7066: 7060: 7058: 7054: 7053: 7051: 7050: 7042: 7034: 7029: 7024: 7022:Phenethylamine 7019: 7014: 7006: 6998: 6993: 6988: 6982: 6980: 6976: 6975: 6973: 6972: 6967: 6962: 6957: 6952: 6947: 6941: 6939: 6932: 6926: 6925: 6922: 6921: 6919: 6918: 6913: 6907: 6905: 6899: 6898: 6896: 6895: 6890: 6885: 6880: 6875: 6870: 6865: 6860: 6854: 6852: 6851:Glycine system 6848: 6847: 6845: 6844: 6839: 6834: 6828: 6826: 6822: 6821: 6819: 6818: 6813: 6808: 6803: 6798: 6796:Kynurenic acid 6793: 6788: 6783: 6778: 6773: 6768: 6763: 6757: 6755: 6748: 6739: 6732: 6731: 6724: 6723: 6716: 6709: 6701: 6692: 6691: 6688: 6683: 6678: 6673: 6668: 6663: 6658: 6653: 6648: 6636: 6635: 6632: 6631: 6629: 6628: 6623: 6616: 6613: 6612: 6610: 6609: 6604: 6598: 6596: 6584: 6580: 6579: 6577: 6576: 6570: 6568: 6564: 6563: 6561: 6560: 6554: 6552: 6548: 6547: 6544: 6543: 6541: 6540: 6535: 6532:Hydroxyproline 6529: 6523: 6518: 6513: 6507: 6501: 6495: 6489: 6483: 6476: 6474: 6466: 6465: 6463: 6462: 6456: 6454: 6444: 6443: 6441: 6440: 6438:Enduracididine 6435: 6428: 6426: 6416: 6415: 6413: 6412: 6407: 6401: 6399: 6390: 6380: 6379: 6377: 6376: 6371: 6366: 6361: 6356: 6350: 6348: 6341: 6340: 6338: 6337: 6331: 6324: 6322: 6316: 6315: 6313: 6312: 6307: 6302: 6296: 6294: 6288: 6287: 6285: 6284: 6282:Hydroxyproline 6278: 6276: 6269: 6268: 6261: 6260: 6253: 6246: 6238: 6232: 6231: 6226: 6221: 6216: 6211: 6180:(4): 217–227. 6165: 6120: 6119:External links 6117: 6114: 6113: 6056: 6021: 5976: 5923: 5866: 5859: 5833: 5790: 5763:(8): 1075–81. 5743: 5724:(3): 246–252. 5713: 5700: 5673:(11): 731–43. 5657: 5636:(2): S19–S26. 5623: 5612: 5606:978-3527306732 5605: 5577: 5526: 5467: 5418: 5369: 5367: 5366: 5352: 5331: 5327: 5290: 5244: 5235: 5172: 5157: 5131: 5091: 5088: 5087: 5066: 5025: 4988: 4951: 4914: 4877: 4840: 4797: 4744: 4699: 4669: 4662: 4655: 4629: 4580: 4557: 4522: 4515: 4495: 4474:(5): 317–322. 4454: 4413: 4362: 4313: 4294:(2): 511–607. 4275: 4240: 4205: 4170: 4121: 4086:(2): 489–493. 4070: 4043:(6): 284–290. 4024: 4009: 3983: 3956:(6): 562–573. 3950:Neuroscientist 3940: 3921: 3914: 3891: 3884: 3878:. Birkhäuser. 3866: 3839: 3790: 3783: 3765: 3744:10.1038/nm1604 3721: 3672: 3623: 3582: 3523: 3485: 3473: 3438: 3395: 3353: 3312: 3283:(11): 3760–5. 3263: 3201: 3155: 3146: 3085: 3036: 3017:(2): 1005–15. 3001: 2980:10.1038/nrn920 2974:(9): 728–739. 2954: 2925:(7): 2343–60. 2905: 2872:Neurosci. Lett 2862: 2813: 2764: 2715: 2666: 2639:(11): 780–90. 2623: 2608: 2578: 2571: 2545: 2538: 2518: 2483: 2454:(3): 195–200. 2431: 2396:(9): 523–539. 2380: 2329: 2274: 2212: 2205: 2185: 2131: 2112:(1): 103–108. 2091: 2085:978-1498754286 2084: 2059: 2058: 2056: 2053: 2050: 2049: 2037: 2036:Many more GABA 2028: 2027: 2025: 2022: 2021: 2020: 2015: 2010: 2005: 2003:neuropathology 1993: 1988: 1983: 1978: 1973: 1967: 1960: 1957: 1948: 1945: 1918: 1917: 1899:GABA analogues 1896: 1866: 1848: 1847: 1846: 1835: 1812: 1803: 1802: 1795: 1793: 1712: 1710: 1703: 1667: 1654: 1653: 1640: 1634: 1633: 1628: 1621: 1620: 1603: 1597: 1596: 1538: 1532: 1531: 1513: 1509: 1508: 1505: 1502: 1492: 1488: 1485: 1464: 1461: 1404:GABA receptors 1395: 1392: 1368:2-oxoglutarate 1360: 1357: 1295: 1292: 1272: 1269: 1241: 1238: 1104: 1101: 1094: 1034: 1031: 1006: 959: 958: 942: 938: 929: 916: 913: 911: 908: 882:nervous system 847: 844: 843: 838: 816: 815: 811:standard state 808: 805: 804: 801: 792: 790: 787: 786: 779: 778: 775: 772: 769: 768: 759: 758: 754: 753: 751: 750: 746: 743: 739: 735: 733: 729: 719: 718: 715: 706: 705: 702: 697: 694: 693: 690: 684: 683: 680: 674: 673: 670: 664: 663: 660: 656: 655: 649: 643: 642: 639: 630: 624: 619: 614: 611: 610: 606: 605: 603: 602: 599: 591: 590: 589: 586: 585: 583: 582: 578: 575: 574: 572: 568: 565: 564: 556: 555: 554: 551: 550: 548: 547: 534: 532: 520: 517: 516: 514: 513: 505: 503: 497: 496: 494: 493: 489: 487: 481: 480: 478: 477: 469: 467: 459: 456: 455: 448: 442: 441: 439: 438: 430: 428: 422: 421: 419: 418: 410: 408: 403: 400: 399: 396: 391: 388: 387: 385: 384: 380: 378: 370: 369: 359: 351: 350: 348: 347: 339: 337: 331: 330: 328: 327: 319: 317: 311: 310: 308: 307: 299: 297: 291: 290: 288: 287: 279: 277: 271: 270: 267: 262: 259: 258: 256: 255: 247: 245: 238: 235: 234: 232: 231: 223: 221: 216: 213: 212: 208: 207: 203:Piperidic acid 196: 192: 191: 187: 186: 180: 179: 67: 66:Pronunciation 63: 62: 58: 57: 49: 48: 26: 9: 6: 4: 3: 2: 9939: 9928: 9925: 9923: 9920: 9918: 9915: 9913: 9910: 9908: 9905: 9903: 9900: 9898: 9895: 9893: 9890: 9888: 9885: 9883: 9880: 9879: 9877: 9862: 9861: 9857: 9855: 9854: 9846: 9844: 9843: 9839: 9837: 9836: 9832: 9829: 9828: 9825: 9815: 9812: 9811: 9809: 9807: 9803: 9800: 9796: 9786: 9785:3-Methyl-GABA 9783: 9780: 9779: 9776: 9773: 9771: 9768: 9766: 9765:Valproic acid 9763: 9761: 9758: 9756: 9753: 9751: 9748: 9746: 9743: 9740: 9736: 9733: 9731: 9728: 9726: 9723: 9721: 9715: 9713: 9710: 9708: 9705: 9703: 9700: 9698: 9695: 9693: 9690: 9688: 9685: 9683: 9680: 9677: 9676: 9674: 9669: 9663: 9657: 9656:3-Methyl-GABA 9654: 9651: 9650: 9647: 9646:Semicarbazide 9644: 9642: 9641:-Allylglycine 9636: 9634: 9631: 9629: 9626: 9623: 9622: 9620: 9615: 9609: 9606: 9604: 9600: 9590: 9587: 9585: 9582: 9580: 9577: 9575: 9572: 9570: 9567: 9565: 9562: 9560: 9557: 9555: 9552: 9550: 9547: 9545: 9542: 9540: 9537: 9534: 9533: 9531: 9526: 9520: 9514: 9511: 9509: 9506: 9504: 9501: 9499: 9496: 9494: 9491: 9489: 9486: 9484: 9481: 9479: 9476: 9474: 9471: 9469: 9468:Ibotenic acid 9466: 9464: 9461: 9459: 9456: 9454: 9451: 9449: 9446: 9444: 9441: 9439: 9436: 9434: 9431: 9429: 9426: 9424: 9421: 9418: 9417: 9415: 9410: 9404: 9401: 9399: 9395: 9391: 9388: 9384: 9378: 9369: 9364: 9362: 9357: 9355: 9350: 9349: 9346: 9334: 9333: 9329: 9327: 9326: 9318: 9316: 9315: 9311: 9308: 9307: 9304: 9294: 9291: 9288: 9287: 9284: 9281: 9279: 9276: 9274: 9271: 9269: 9266: 9264: 9261: 9259: 9256: 9254: 9251: 9249: 9246: 9244: 9241: 9239: 9236: 9234: 9231: 9229: 9226: 9224: 9221: 9218: 9217: 9214: 9211: 9209: 9206: 9204: 9201: 9199: 9196: 9194: 9191: 9189: 9186: 9184: 9181: 9179: 9176: 9174: 9171: 9168: 9167: 9164: 9161: 9159: 9156: 9154: 9151: 9149: 9146: 9144: 9141: 9139: 9136: 9134: 9131: 9129: 9126: 9124: 9121: 9119: 9116: 9114: 9111: 9109: 9106: 9104: 9101: 9099: 9096: 9094: 9091: 9089: 9086: 9084: 9081: 9079: 9076: 9074: 9071: 9069: 9066: 9064: 9061: 9059: 9056: 9054: 9053:Aceburic acid 9051: 9049: 9046: 9044: 9041: 9039: 9036: 9033: 9032: 9030: 9025: 9016: 9013: 9011: 9007: 8997: 8994: 8992: 8989: 8987: 8984: 8982: 8979: 8976: 8972: 8968: 8965: 8963: 8960: 8958: 8955: 8953: 8950: 8947: 8946: 8943: 8940: 8938: 8936: 8932: 8930: 8927: 8925: 8922: 8920: 8917: 8915: 8912: 8910: 8907: 8905: 8902: 8900: 8897: 8895: 8892: 8890: 8887: 8885: 8882: 8880: 8877: 8875: 8872: 8870: 8867: 8865: 8863: 8859: 8857: 8854: 8852: 8849: 8847: 8844: 8842: 8839: 8837: 8834: 8832: 8829: 8827: 8824: 8821: 8820: 8817: 8814: 8812: 8809: 8807: 8804: 8802: 8799: 8796: 8795: 8792: 8789: 8787: 8784: 8782: 8779: 8777: 8774: 8772: 8769: 8767: 8764: 8762: 8760: 8756: 8754: 8751: 8749: 8746: 8744: 8743:Ibotenic acid 8741: 8739: 8736: 8734: 8731: 8729: 8726: 8724: 8721: 8719: 8716: 8714: 8711: 8708: 8707: 8705: 8700: 8690: 8684: 8681: 8679: 8676: 8674: 8671: 8669: 8666: 8664: 8661: 8659: 8656: 8654: 8651: 8649: 8646: 8644: 8641: 8639: 8636: 8634: 8631: 8629: 8626: 8624: 8621: 8619: 8616: 8614: 8611: 8609: 8606: 8604: 8601: 8599: 8596: 8594: 8591: 8589: 8588:Propybicyphat 8586: 8584: 8581: 8578: 8574: 8570: 8566: 8563: 8561: 8558: 8556: 8553: 8551: 8550:Oenanthotoxin 8548: 8545: 8541: 8537: 8533: 8529: 8525: 8522: 8520: 8517: 8515: 8512: 8510: 8507: 8505: 8502: 8500: 8497: 8495: 8492: 8490: 8487: 8485: 8482: 8480: 8477: 8475: 8472: 8470: 8467: 8465: 8462: 8460: 8459:Iomazenil (I) 8457: 8455: 8452: 8450: 8447: 8445: 8442: 8439: 8438:ciprofloxacin 8435: 8432: 8430: 8427: 8424: 8420: 8419:amentoflavone 8416: 8413: 8410: 8406: 8403: 8401: 8398: 8396: 8393: 8391: 8388: 8386: 8383: 8381: 8378: 8376: 8373: 8371: 8368: 8366: 8363: 8361: 8358: 8356: 8355:Cyclothiazide 8353: 8351: 8348: 8346: 8343: 8341: 8338: 8336: 8333: 8331: 8328: 8326: 8323: 8321: 8318: 8315: 8311: 8307: 8303: 8300: 8298: 8295: 8293: 8290: 8287: 8283: 8279: 8275: 8272: 8270: 8267: 8265: 8262: 8260: 8257: 8255: 8252: 8250: 8247: 8245: 8242: 8240: 8237: 8235: 8232: 8230: 8227: 8225: 8222: 8220: 8217: 8215: 8212: 8210: 8207: 8205: 8202: 8199: 8198: 8195: 8192: 8190: 8187: 8185: 8182: 8180: 8177: 8175: 8172: 8170: 8167: 8165: 8162: 8160: 8157: 8155: 8152: 8150: 8147: 8145: 8144:Famiraprinium 8142: 8140: 8137: 8135: 8132: 8130: 8127: 8124: 8123: 8119: 8115: 8111: 8110:diethyl ether 8107: 8103: 8099: 8095: 8092: 8089: 8085: 8082: 8080: 8077: 8074: 8070: 8067: 8065: 8062: 8059: 8055: 8052: 8050: 8047: 8045: 8042: 8039: 8035: 8032: 8029: 8025: 8022: 8020: 8017: 8014: 8010: 8007: 8005: 8002: 7999: 7995: 7992: 7990: 7987: 7985: 7984:Norfluoxetine 7982: 7979: 7975: 7971: 7967: 7963: 7959: 7955: 7951: 7947: 7944: 7942: 7939: 7937: 7934: 7931: 7927: 7923: 7919: 7916: 7914: 7911: 7909: 7906: 7904: 7901: 7898: 7894: 7891: 7888: 7884: 7881: 7879: 7876: 7874: 7871: 7868: 7864: 7860: 7857: 7854: 7850: 7847: 7845: 7842: 7840: 7837: 7834: 7830: 7827: 7825: 7824:Clomethiazole 7822: 7820: 7819:Chlormezanone 7817: 7815: 7812: 7810: 7809:Carbamazepine 7807: 7804: 7800: 7797: 7794: 7790: 7787: 7784: 7780: 7777: 7774: 7773:phenobarbital 7770: 7767: 7764: 7760: 7757: 7755: 7752: 7749: 7745: 7741: 7738: 7736: 7733: 7731: 7726: 7725: 7722: 7719: 7717: 7714: 7712: 7709: 7706: 7702: 7699: 7697: 7694: 7692: 7689: 7687: 7684: 7682: 7679: 7677: 7676:Quisqualamine 7674: 7672: 7669: 7667: 7664: 7662: 7659: 7657: 7654: 7652: 7649: 7647: 7644: 7642: 7639: 7636: 7632: 7629: 7627: 7624: 7622: 7619: 7617: 7614: 7612: 7611:Methylglyoxal 7609: 7606: 7602: 7599: 7597: 7594: 7592: 7589: 7587: 7584: 7582: 7579: 7577: 7574: 7572: 7569: 7567: 7564: 7562: 7561:Ibotenic acid 7559: 7557: 7554: 7552: 7549: 7547: 7544: 7542: 7539: 7537: 7534: 7532: 7529: 7527: 7524: 7522: 7519: 7517: 7514: 7511: 7510:phenobarbital 7507: 7504: 7502: 7499: 7497: 7494: 7491: 7490: 7488: 7483: 7474: 7471: 7469: 7465: 7461: 7458: 7448: 7443: 7441: 7436: 7434: 7429: 7428: 7425: 7409: 7402: 7400: 7393: 7391: 7388: 7386: 7379: 7377: 7374: 7373: 7371: 7367: 7357: 7354: 7352: 7345: 7343: 7340: 7339: 7337: 7333: 7323: 7322:Acetylcholine 7320: 7319: 7317: 7313: 7310: 7308:Miscellaneous 7306: 7301: 7298: 7294: 7280: 7277: 7275: 7272: 7270: 7267: 7266: 7264: 7261: 7257: 7254: 7250: 7247: 7244: 7240: 7225: 7221: 7220: 7217: 7214: 7212: 7211:Neurosteroids 7208: 7202: 7199: 7197: 7194: 7192: 7189: 7187: 7184: 7182: 7179: 7177: 7174: 7172: 7169: 7167: 7164: 7162: 7159: 7157: 7154: 7152: 7149: 7147: 7144: 7142: 7139: 7137: 7134: 7132: 7129: 7127: 7124: 7123: 7121: 7117: 7114: 7111: 7107: 7092: 7088: 7087: 7084: 7081: 7079: 7078:Neuropeptides 7075: 7065: 7062: 7061: 7059: 7055: 7049: 7047: 7043: 7041: 7039: 7035: 7033: 7030: 7028: 7025: 7023: 7020: 7018: 7015: 7013: 7011: 7007: 7005: 7003: 6999: 6997: 6994: 6992: 6989: 6987: 6984: 6983: 6981: 6977: 6971: 6968: 6966: 6963: 6961: 6958: 6956: 6953: 6951: 6948: 6946: 6943: 6942: 6940: 6936: 6933: 6931: 6927: 6917: 6914: 6912: 6909: 6908: 6906: 6904: 6900: 6894: 6891: 6889: 6886: 6884: 6881: 6879: 6876: 6874: 6871: 6869: 6866: 6864: 6861: 6859: 6856: 6855: 6853: 6849: 6843: 6840: 6838: 6835: 6833: 6830: 6829: 6827: 6823: 6817: 6814: 6812: 6809: 6807: 6804: 6802: 6799: 6797: 6794: 6792: 6789: 6787: 6784: 6782: 6779: 6777: 6774: 6772: 6769: 6767: 6764: 6762: 6759: 6758: 6756: 6752: 6749: 6743: 6740: 6737: 6733: 6729: 6722: 6717: 6715: 6710: 6708: 6703: 6702: 6699: 6687: 6684: 6682: 6681:D-amino acids 6679: 6677: 6674: 6672: 6669: 6667: 6664: 6662: 6659: 6657: 6654: 6652: 6649: 6647: 6643: 6641: 6637: 6633: 6627: 6624: 6621: 6618: 6617: 6608: 6605: 6603: 6600: 6599: 6597: 6595: 6592: 6588: 6585: 6583:Intermediates 6581: 6575: 6572: 6571: 6569: 6565: 6559: 6556: 6555: 6553: 6549: 6539: 6536: 6533: 6530: 6527: 6524: 6522: 6519: 6517: 6514: 6511: 6508: 6505: 6502: 6499: 6498:Penicillamine 6496: 6494:(insectiside) 6493: 6490: 6487: 6484: 6481: 6478: 6477: 6475: 6471: 6461: 6458: 6457: 6455: 6453: 6449: 6439: 6436: 6433: 6430: 6429: 6427: 6425: 6421: 6411: 6408: 6406: 6403: 6402: 6400: 6398: 6397:Beta-peptides 6394: 6391: 6389: 6385: 6381: 6375: 6372: 6370: 6367: 6365: 6362: 6360: 6357: 6355: 6352: 6351: 6349: 6347: 6342: 6335: 6332: 6329: 6326: 6325: 6323: 6321: 6317: 6311: 6308: 6306: 6303: 6301: 6298: 6297: 6295: 6293: 6289: 6283: 6280: 6279: 6277: 6275: 6270: 6266: 6259: 6254: 6252: 6247: 6245: 6240: 6239: 6236: 6230: 6227: 6225: 6222: 6220: 6217: 6215: 6212: 6209: 6205: 6201: 6196: 6191: 6187: 6183: 6179: 6175: 6171: 6166: 6162: 6158: 6153: 6148: 6144: 6140: 6136: 6132: 6128: 6123: 6122: 6109: 6105: 6100: 6095: 6091: 6087: 6083: 6079: 6075: 6071: 6067: 6060: 6052: 6048: 6044: 6040: 6036: 6032: 6025: 6017: 6013: 6008: 6003: 6000:(2): 318–30. 5999: 5995: 5991: 5989: 5980: 5972: 5968: 5964: 5960: 5955: 5950: 5946: 5942: 5938: 5934: 5927: 5919: 5915: 5910: 5905: 5901: 5897: 5893: 5889: 5885: 5881: 5877: 5870: 5862: 5856: 5852: 5848: 5844: 5837: 5829: 5825: 5821: 5817: 5813: 5809: 5805: 5801: 5794: 5786: 5782: 5778: 5774: 5770: 5766: 5762: 5758: 5757:Phytother Res 5754: 5747: 5739: 5735: 5731: 5727: 5723: 5719: 5711: 5704: 5696: 5692: 5688: 5684: 5680: 5676: 5672: 5668: 5661: 5653: 5649: 5644: 5639: 5635: 5631: 5627: 5616: 5608: 5602: 5598: 5594: 5590: 5589: 5581: 5573: 5569: 5565: 5561: 5557: 5553: 5549: 5545: 5541: 5537: 5530: 5522: 5518: 5513: 5508: 5503: 5498: 5494: 5490: 5487:(9): 4417–8. 5486: 5482: 5478: 5471: 5463: 5459: 5454: 5449: 5445: 5441: 5438:(2): 625–34. 5437: 5433: 5429: 5422: 5414: 5410: 5405: 5400: 5396: 5392: 5388: 5384: 5380: 5373: 5363: 5359: 5355: 5349: 5345: 5341: 5337: 5328: 5324: 5320: 5316: 5312: 5308: 5304: 5299: 5298: 5294: 5286: 5282: 5278: 5274: 5270: 5269:10.1038/38738 5266: 5262: 5258: 5254: 5250: 5239: 5231: 5227: 5222: 5217: 5212: 5207: 5203: 5199: 5195: 5191: 5187: 5185: 5176: 5168: 5164: 5160: 5154: 5150: 5146: 5142: 5135: 5121:on 2013-10-16 5117: 5113: 5109: 5102: 5095: 5084: 5080: 5076: 5072: 5067: 5063: 5059: 5055: 5051: 5047: 5043: 5039: 5035: 5031: 5026: 5022: 5018: 5014: 5010: 5006: 5002: 4999:(5): 759–65. 4998: 4994: 4989: 4985: 4981: 4977: 4973: 4969: 4965: 4961: 4957: 4952: 4948: 4944: 4940: 4936: 4932: 4928: 4925:(2): 169–92. 4924: 4920: 4915: 4911: 4907: 4903: 4899: 4895: 4891: 4888:(3): 362–72. 4887: 4883: 4878: 4874: 4870: 4866: 4862: 4858: 4854: 4851:(7): 565–75. 4850: 4846: 4841: 4837: 4833: 4828: 4823: 4819: 4815: 4811: 4807: 4803: 4798: 4794: 4790: 4785: 4780: 4775: 4770: 4766: 4762: 4758: 4754: 4750: 4745: 4741: 4737: 4733: 4729: 4725: 4721: 4717: 4713: 4709: 4705: 4700: 4696: 4692: 4688: 4684: 4680: 4676: 4671: 4670: 4666: 4658: 4652: 4648: 4643: 4642: 4633: 4625: 4621: 4617: 4613: 4608: 4603: 4599: 4595: 4591: 4584: 4576: 4572: 4568: 4564: 4560: 4558:9780128104132 4554: 4550: 4546: 4542: 4535: 4533: 4531: 4529: 4527: 4518: 4512: 4508: 4507: 4499: 4491: 4487: 4482: 4477: 4473: 4469: 4465: 4458: 4450: 4446: 4441: 4436: 4433:(1): 151–60. 4432: 4428: 4424: 4417: 4409: 4405: 4400: 4395: 4390: 4385: 4381: 4377: 4373: 4366: 4358: 4354: 4350: 4346: 4341: 4336: 4333:(1): 104–10. 4332: 4328: 4324: 4317: 4309: 4305: 4301: 4297: 4293: 4289: 4282: 4280: 4271: 4267: 4263: 4259: 4255: 4251: 4244: 4236: 4232: 4228: 4224: 4221:(10): 491–3. 4220: 4216: 4209: 4201: 4197: 4193: 4189: 4185: 4181: 4174: 4166: 4162: 4157: 4152: 4148: 4144: 4140: 4136: 4135:Plant Physiol 4132: 4125: 4117: 4113: 4109: 4105: 4101: 4097: 4093: 4089: 4085: 4081: 4074: 4066: 4062: 4058: 4054: 4050: 4046: 4042: 4038: 4031: 4029: 4020: 4016: 4012: 4006: 4002: 3998: 3994: 3987: 3979: 3975: 3971: 3967: 3963: 3959: 3955: 3951: 3944: 3936: 3932: 3925: 3917: 3911: 3907: 3906: 3898: 3896: 3887: 3881: 3877: 3870: 3862: 3858: 3854: 3850: 3843: 3835: 3831: 3827: 3823: 3818: 3813: 3809: 3805: 3801: 3794: 3786: 3780: 3776: 3769: 3761: 3757: 3753: 3749: 3745: 3741: 3737: 3733: 3725: 3717: 3713: 3708: 3703: 3699: 3695: 3691: 3687: 3683: 3676: 3668: 3664: 3659: 3654: 3650: 3646: 3643:(6): 465–70. 3642: 3638: 3634: 3627: 3619: 3615: 3610: 3605: 3601: 3597: 3593: 3586: 3578: 3574: 3569: 3564: 3559: 3554: 3550: 3546: 3543:(8): e42959. 3542: 3538: 3534: 3527: 3519: 3515: 3511: 3507: 3503: 3499: 3495: 3491: 3480: 3478: 3469: 3465: 3461: 3457: 3453: 3449: 3448:Life Sciences 3442: 3434: 3430: 3426: 3422: 3418: 3414: 3411:(2): 363–72. 3410: 3406: 3399: 3391: 3387: 3382: 3377: 3373: 3369: 3365: 3357: 3349: 3345: 3340: 3335: 3331: 3327: 3323: 3316: 3308: 3304: 3299: 3294: 3290: 3286: 3282: 3278: 3274: 3267: 3259: 3255: 3250: 3245: 3240: 3235: 3231: 3227: 3223: 3219: 3215: 3208: 3206: 3197: 3193: 3189: 3185: 3181: 3177: 3173: 3169: 3165: 3161: 3150: 3142: 3138: 3133: 3128: 3123: 3118: 3114: 3110: 3106: 3102: 3101: 3096: 3089: 3081: 3077: 3072: 3067: 3063: 3059: 3055: 3051: 3050:Epilepsy Curr 3047: 3040: 3032: 3028: 3024: 3020: 3016: 3012: 3005: 2997: 2993: 2989: 2985: 2981: 2977: 2973: 2969: 2965: 2958: 2950: 2946: 2941: 2936: 2932: 2928: 2924: 2920: 2916: 2909: 2901: 2897: 2893: 2889: 2885: 2881: 2877: 2873: 2866: 2858: 2854: 2850: 2846: 2841: 2836: 2833:(4): 521–32. 2832: 2828: 2824: 2817: 2809: 2805: 2800: 2795: 2791: 2787: 2783: 2779: 2775: 2768: 2760: 2756: 2751: 2746: 2742: 2738: 2734: 2730: 2726: 2719: 2711: 2707: 2703: 2699: 2694: 2689: 2685: 2681: 2677: 2670: 2662: 2658: 2654: 2650: 2646: 2642: 2638: 2634: 2627: 2619: 2615: 2611: 2609:9780123668721 2605: 2601: 2597: 2593: 2589: 2582: 2574: 2568: 2564: 2559: 2558: 2549: 2541: 2535: 2531: 2530: 2522: 2514: 2510: 2506: 2502: 2498: 2494: 2487: 2479: 2475: 2470: 2465: 2461: 2457: 2453: 2449: 2448:Neurosci Bull 2445: 2438: 2436: 2427: 2423: 2419: 2415: 2411: 2407: 2403: 2399: 2395: 2391: 2384: 2376: 2372: 2368: 2364: 2360: 2356: 2352: 2348: 2344: 2340: 2333: 2325: 2321: 2317: 2313: 2309: 2305: 2301: 2297: 2293: 2289: 2285: 2278: 2270: 2266: 2261: 2256: 2252: 2248: 2243: 2238: 2234: 2230: 2226: 2219: 2217: 2208: 2202: 2198: 2197: 2189: 2181: 2177: 2172: 2167: 2162: 2157: 2153: 2149: 2148:Front Psychol 2145: 2138: 2136: 2127: 2123: 2119: 2115: 2111: 2107: 2100: 2098: 2096: 2087: 2081: 2077: 2073: 2072: 2064: 2060: 2047: 2043: 2033: 2029: 2019: 2016: 2014: 2011: 2009: 2006: 2004: 2001: 2000:neuromuscular 1997: 1994: 1992: 1989: 1987: 1984: 1982: 1981:GABA receptor 1979: 1977: 1976:GABA analogue 1974: 1971: 1968: 1966: 1963: 1962: 1956: 1954: 1944: 1942: 1939:(GABAL) as a 1938: 1934: 1930: 1926: 1922: 1916: 1912: 1908: 1904: 1900: 1897: 1894: 1890: 1886: 1882: 1878: 1874: 1870: 1867: 1864: 1860: 1856: 1852: 1849: 1844: 1840: 1837:Antagonists: 1836: 1833: 1829: 1825: 1821: 1817: 1816: 1810: 1809: 1808: 1794: 1790: 1779: 1776: 1772: 1769: 1765: 1762: 1758: 1755: 1751: 1748: –  1747: 1743: 1742:Find sources: 1737: 1733: 1727: 1726: 1722: 1718: 1713:This section 1711: 1702: 1701: 1698: 1696: 1692: 1688: 1684: 1683:dihydrokavain 1680: 1676: 1671: 1665: 1661: 1652: 1651:amentoflavone 1648: 1647:oenanthotoxin 1644: 1641: 1639: 1636: 1635: 1632: 1629: 1626: 1623: 1622: 1619: 1615: 1611: 1607: 1604: 1602: 1599: 1598: 1594: 1590: 1586: 1582: 1578: 1574: 1570: 1566: 1562: 1558: 1554: 1550: 1546: 1542: 1539: 1537: 1534: 1533: 1529: 1525: 1521: 1517: 1514: 1511: 1510: 1506: 1500: 1499: 1496: 1484: 1482: 1478: 1474: 1470: 1460: 1458: 1454: 1452: 1447: 1443: 1438: 1436: 1432: 1428: 1423: 1421: 1417: 1413: 1409: 1405: 1401: 1391: 1389: 1385: 1381: 1380:succinic acid 1377: 1373: 1369: 1365: 1356: 1354: 1349: 1347: 1343: 1339: 1334: 1332: 1328: 1324: 1320: 1316: 1313: 1309: 1300: 1291: 1289: 1283: 1281: 1276: 1268: 1265: 1260: 1255: 1251: 1247: 1237: 1235: 1231: 1227: 1222: 1220: 1216: 1211: 1209: 1205: 1201: 1197: 1193: 1191: 1187: 1183: 1179: 1175: 1171: 1167: 1163: 1158: 1156: 1151: 1149: 1145: 1142: 1138: 1134: 1130: 1122: 1118: 1114: 1109: 1100: 1098: 1090: 1086: 1082: 1077: 1075: 1071: 1067: 1062: 1060: 1056: 1052: 1047: 1045: 1044:glutamatergic 1041: 1030: 1028: 1023: 1019: 1014: 1010: 1002: 1000: 996: 992: 988: 984: 980: 976: 972: 963: 956: 952: 948: 945: 939: 936: 932: 926: 925: 924: 922: 921:GABA receptor 907: 905: 901: 896: 894: 890: 885: 883: 879: 875: 872: 868: 865: 861: 857: 853: 841: 834: 829: 812: 806: 802: 798: 789: 788: 784: 780: 776: 771: 770: 766: 765: 760: 755: 744: 737: 736: 734: 728: 724: 721: 720: 716: 714: 713: 708: 707: 704:130 g/100 ml 703: 700: 696: 695: 691: 689: 688:Boiling point 686: 685: 681: 679: 678:Melting point 676: 675: 671: 669: 666: 665: 661: 658: 657: 650: 648: 645: 644: 620: 617: 613: 612: 607: 598: 597: 594: 587: 573: 563: 562: 559: 552: 544: 540: 539:DTXSID6035106 536: 535: 533: 523: 519: 518: 511: 507: 506: 504: 502: 499: 498: 491: 490: 488: 486: 483: 482: 475: 471: 470: 468: 462: 458: 457: 453: 449: 447: 444: 443: 436: 432: 431: 429: 427: 424: 423: 416: 412: 411: 409: 406: 402: 401: 397: 394: 390: 389: 382: 381: 379: 377: 372: 371: 367: 363: 360: 358: 356:ECHA InfoCard 353: 352: 345: 341: 340: 338: 336: 333: 332: 325: 321: 320: 318: 316: 313: 312: 305: 301: 300: 298: 296: 293: 292: 285: 281: 280: 278: 276: 273: 272: 268: 265: 261: 260: 253: 249: 248: 246: 242: 237: 236: 229: 225: 224: 222: 219: 215: 214: 209: 193: 185: 181: 175: 149: 68: 65: 64: 59: 55: 50: 46: 41: 33: 19: 9858: 9847: 9840: 9833: 9781: 9750:Valnoctamide 9720:-Cycloserine 9678: 9652: 9624: 9558: 9535: 9419: 9330: 9319: 9312: 9289: 9220:Antagonists: 9219: 9169: 9034: 9010:Metabotropic 8981:Pregnanolone 8975:picrotoxinin 8948: 8934: 8861: 8831:(S)-4-ACPBPA 8826:(S)-2-MeGABA 8823:Antagonists: 8822: 8797: 8786:Thiomuscimol 8758: 8709: 8573:picrotoxinin 8536:enzalutamide 8532:bicalutamide 8454:Golexanolone 8350:Cloflubicyne 8200: 8126:Antagonists: 8125: 8038:methaqualone 8013:glutethimide 7989:Petrichloral 7950:β-carbolines 7769:Barbiturates 7727: 7711:Thiomuscimol 7516:Beta-Alanine 7506:Barbiturates 7496:(+)-Catechin 7492: 7376:Acetaldehyde 7045: 7037: 7009: 7001: 6979:Trace amines 6638: 6591:Mitochondria 6526:Homocysteine 6506:(Alzheimers) 6488:(metabolism) 6207: 6177: 6173: 6134: 6130: 6076:(5): 408–9. 6073: 6069: 6059: 6037:(3): 110–5. 6034: 6030: 6024: 5997: 5993: 5987: 5979: 5936: 5932: 5926: 5883: 5879: 5869: 5842: 5836: 5806:(2): 124–8. 5803: 5799: 5793: 5760: 5756: 5752: 5746: 5721: 5717: 5709: 5703: 5670: 5666: 5660: 5633: 5629: 5615: 5586: 5580: 5539: 5535: 5529: 5484: 5480: 5470: 5435: 5431: 5421: 5389:(1): 190–7. 5386: 5382: 5372: 5335: 5306: 5302: 5293: 5252: 5248: 5238: 5193: 5189: 5183: 5175: 5140: 5134: 5123:. Retrieved 5116:the original 5111: 5107: 5094: 5074: 5037: 5033: 4996: 4992: 4962:(1): 35–43. 4959: 4955: 4922: 4918: 4885: 4881: 4848: 4844: 4809: 4805: 4756: 4752: 4707: 4703: 4681:(1): 20–34. 4678: 4674: 4665: 4640: 4632: 4597: 4593: 4583: 4540: 4509:. ABC-CLIO. 4505: 4498: 4471: 4467: 4457: 4430: 4426: 4416: 4379: 4375: 4365: 4330: 4326: 4316: 4291: 4288:Physiol. Rev 4287: 4253: 4249: 4243: 4218: 4214: 4208: 4183: 4179: 4173: 4138: 4134: 4124: 4083: 4080:Neuroscience 4079: 4073: 4040: 4036: 3992: 3986: 3953: 3949: 3943: 3934: 3930: 3924: 3904: 3875: 3869: 3852: 3848: 3842: 3807: 3803: 3793: 3774: 3768: 3738:(7): 862–7. 3735: 3731: 3724: 3689: 3686:eBioMedicine 3685: 3675: 3640: 3637:Autoimmunity 3636: 3626: 3599: 3595: 3585: 3540: 3536: 3526: 3493: 3489: 3451: 3447: 3441: 3408: 3405:J. Neurochem 3404: 3398: 3371: 3367: 3356: 3329: 3325: 3315: 3280: 3276: 3266: 3221: 3217: 3163: 3159: 3149: 3107:(2): e4371. 3104: 3098: 3088: 3056:(5): 137–9. 3053: 3049: 3039: 3014: 3010: 3004: 2971: 2967: 2957: 2922: 2918: 2908: 2875: 2871: 2865: 2830: 2826: 2816: 2781: 2777: 2767: 2732: 2728: 2718: 2683: 2679: 2669: 2636: 2632: 2626: 2591: 2581: 2557:Neuroscience 2556: 2548: 2532:. Springer. 2528: 2521: 2496: 2493:Physiol. Rev 2492: 2486: 2451: 2447: 2393: 2389: 2383: 2342: 2338: 2332: 2291: 2287: 2283: 2277: 2232: 2228: 2195: 2188: 2151: 2147: 2109: 2105: 2070: 2063: 2032: 1950: 1935:(ALDH) with 1919: 1892: 1855:deramciclane 1806: 1784: 1774: 1767: 1760: 1753: 1741: 1721:verification 1714: 1672: 1657: 1581:methaqualone 1541:Barbiturates 1490: 1466: 1450: 1439: 1424: 1407: 1397: 1394:Pharmacology 1362: 1350: 1335: 1305: 1294:Biosynthesis 1284: 1277: 1274: 1254:conformation 1243: 1223: 1212: 1204:inflammatory 1200:Immune cells 1198: 1194: 1159: 1152: 1126: 1078: 1063: 1048: 1036: 1003: 985:, mediating 968: 949:, which are 918: 903: 897: 886: 859: 855: 851: 850: 782: 773:Main hazards 762: 726: 711: 485:RTECS number 211:Identifiers 195:Other names 9814:Ginkgotoxin 9782:Activators: 9679:Inhibitors: 9653:Activators: 9625:Inhibitors: 9584:Valinomycin 9536:Inhibitors: 9483:NNC 05-2090 9420:Inhibitors: 9398:Transporter 9293:Compound 14 9123:Lesogaberan 8962:Loreclezole 8899:Loreclezole 8836:(S)-4-ACPCA 8816:Lanthanides 8806:Alphaxolone 8748:Isoguvacine 8658:Terbequinil 8528:apalutamide 8519:Nicardipine 8479:Laudanosine 8286:carbapenems 8278:penicillins 8134:Coriamyrtin 8129:Bicuculline 8118:sevoflurane 8114:paraldehyde 8064:Stiripentol 7941:Niacinamide 7926:cholesterol 7908:Loreclezole 7803:meprobamate 7759:Avermectins 7626:Nefiracetam 7591:Kojic amine 7581:Isomuscimol 7576:Isoguvacine 7381:Ammonia (NH 7252:Nucleosides 7012:-Octopamine 7004:-Octopamine 6916:T-HCA (GHC) 6873:Hypotaurine 6825:GABA system 6776:Glutathione 6676:Imino acids 6640:Amino acids 6500:(chelation) 6300:Lanthionine 5954:2440/124330 4382:(8): 2742. 4186:(1): 7–17. 3931:Experientia 3855:: 125–140. 3692:: 283–294. 3496:(1): 21–8. 2919:J. Neurosci 2778:J. Neurosci 2729:J. Neurosci 1715:needs more 1687:methysticin 1606:bicuculline 1589:stiripentol 1557:niacinamide 1524:isoguvacine 1412:lamotrigine 1317:(GAD) with 1144:alpha cells 1131:-producing 923:are known: 900:carboxylate 797:median dose 783:Lethal dose 767:(OHS/OSH): 659:Appearance 609:Properties 362:100.000.235 284:CHEBI:16865 9876:Categories 9775:Vigabatrin 9770:Valpromide 9739:lemon balm 9725:Phenelzine 9707:Gabaculine 9589:Vigabatrin 9554:Evans blue 9498:SKF-89976A 9458:Gabaculine 9433:Arecaidine 9390:modulators 9383:metabolism 9148:SKF-97,541 9058:Arbaclofen 8967:Picrotoxin 8957:Bilobalide 8633:Suritozole 8623:Sarmazenil 8608:Ro 19-4603 8603:Ro 15-4513 8598:Radequinil 8565:Picrotoxin 8544:nilutamide 8514:Naltrexone 8449:Furosemide 8429:Flumazenil 8423:oroxylin A 8415:Flavonoids 8395:Etbicyphat 8325:Bilobalide 8292:Basmisanil 8179:Sinomenine 8174:Securinine 8169:Pitrazepin 8154:Hydrastine 8106:chloroform 8079:Topiramate 8019:Propanidid 7883:Imidazoles 7878:Flupirtine 7873:Fluoxetine 7867:hispidulin 7859:Flavonoids 7814:Chloralose 7799:Carbamates 7763:ivermectin 7701:Terpenoids 7646:PF-6372865 7501:Bamaluzole 7468:Ionotropic 7460:modulators 7369:Candidates 7243:Nucleobase 7032:Tryptamine 7027:Synephrine 6938:Monoamines 6903:GHB system 6736:Amino acid 6666:Glucogenic 6607:Citrulline 6534:(collagen) 6504:Norleucine 6424:Antibiotic 6364:thialysine 6359:Canavanine 6305:Norleucine 5880:Nat Commun 5710:Drosophila 5184:Drosophila 5125:2019-04-01 4141:(1): 1–5. 4037:Physiology 3596:J. Immunol 2565:, box 6D. 2284:Drosophila 2235:: e39383. 2055:References 2008:Spasticity 1931:(ALR) and 1907:gabapentin 1903:pregabalin 1889:lemon balm 1885:vigabatrin 1877:phenelzine 1873:gabaculine 1859:hyperforin 1818:Agonists: 1757:newspapers 1673:The plant 1670:receptor. 1643:furosemide 1618:flumazenil 1469:amino acid 1442:catabolism 1359:Metabolism 1338:putrescine 1331:excitatory 1323:vitamin B6 1288:picrotoxin 1246:zwitterion 1226:epithelium 1133:beta cells 1117:Wistar rat 1046:synapses. 1040:maturation 955:G proteins 864:inhibitory 647:Molar mass 600:NCCCC(=O)O 510:2ACZ6IPC6I 405:IUPHAR/BPS 315:ChemSpider 239:3D model ( 218:CAS Number 9712:Isoniazid 9574:Nigericin 9539:β-Alanine 9513:Tiagabine 9503:SNAP-5114 9428:β-Alanine 9387:transport 9283:SKF-97541 9278:SCH-50911 9268:Phaclofen 9253:CGP-64213 9248:CGP-55845 9243:CGP-54626 9238:CGP-52432 9233:CGP-46381 9228:CGP-35348 9198:CGP-13501 9173:ADX-71441 9158:Tolgabide 9138:Progabide 9133:Picamilon 9118:Isovaline 9035:Agonists: 8937:-3-ACPBPA 8914:SKF-97541 8864:-3-ACPBPA 8791:Tolgabide 8771:Progabide 8766:Picamilon 8710:Agonists: 8618:RO4938581 8613:RO4882224 8540:flutamide 8474:L-655,708 8444:Flurothyl 8345:Cicutoxin 8330:Bupropion 8297:Bemegride 8274:β-Lactams 8264:Amiloride 8094:Volatiles 8028:etazolate 8004:Phenytoin 7962:zopiclone 7954:abecarnil 7913:Monastrol 7903:Lanthanum 7887:etomidate 7849:Fenamates 7844:Etifoxine 7839:Etazepine 7716:Tolgabide 7666:Progabide 7656:Picamilon 7641:Org 20599 7616:Monastrol 7596:L-838,417 7493:Agonists: 7260:Adenosine 7064:Histamine 7048:-Tyramine 7040:-Tyramine 6883:Sarcosine 6863:β-Alanine 6858:α-Alanine 6661:Ketogenic 6651:Essential 6602:Ornithine 6521:Norvaline 6516:Sarcosine 6410:β-Leucine 6405:β-Alanine 6274:cell wall 5667:CNS Drugs 5556:0515-2720 4600:: 12–25. 4594:Epilepsia 4376:Nutrients 4100:0306-4522 4057:1548-9213 2426:260201740 2410:1471-003X 2251:2050-084X 2076:CRC Press 1947:In plants 1915:progabide 1911:picamilon 1881:valproate 1863:tiagabine 1839:phaclofen 1787:June 2015 1631:cicutoxin 1569:etomidate 1528:progabide 1473:qualifier 1463:Chemistry 1457:melatonin 1446:serotonin 1408:GABAergic 1308:glutamate 1264:solvation 1219:cytokines 1174:testicles 1081:embryonic 1055:paracrine 1051:autocrine 1009:receptors 971:GABAergic 871:mammalian 492:ES6300000 383:200-258-6 375:EC Number 9830:See also 9493:Riluzole 9473:Muscimol 9463:Guvacine 9309:See also 9273:Saclofen 9208:rac-BHFF 9203:GS-39783 9193:CGP-7930 9153:SL 75102 9128:Phenibut 9083:Gabamide 9068:Baclofen 8971:picrotin 8924:SR-95813 8919:SR-95318 8841:2-MeTACA 8753:Muscimol 8683:ZK-93426 8653:TCS-1105 8638:TB-21007 8569:picrotin 8509:Naloxone 8494:Morphine 8489:MaxiPost 8409:fipronil 8405:Fiproles 8375:(+)-DMBB 8370:Dieldrin 8269:Anisatin 8184:SR-42641 8084:Valerian 8058:baicalin 8054:Skullcap 7998:propofol 7978:zaleplon 7970:zolpidem 7863:apigenin 7783:diazepam 7740:Alcohols 7681:SL-75102 7671:Propofol 7651:Phenibut 7621:Muscimol 7605:honokiol 7571:iso-THIP 7566:iso-THAZ 7541:Gabamide 7457:receptor 7299:-derived 7245:-derived 7226:instead. 7181:Oleamide 7112:-derived 7093:instead. 6950:Dopamine 6761:Agmatine 6738:-derived 6538:Hypusine 6492:Canaline 6204:25485164 6161:32166183 6108:19704616 6051:15003233 6016:21070411 5971:19475505 5963:27838745 5918:26219411 5886:: 7879. 5820:21296127 5785:23127112 5777:19165747 5738:16129424 5695:34322458 5687:12383029 5652:17557503 5572:24494744 5542:: 3–14. 5521:10781032 5413:18585399 5362:17175815 5323:17175815 5230:12692303 5167:18175096 5083:22787590 5021:12626366 4984:11605131 4976:11750861 4947:36197603 4939:15694225 4902:16432684 4873:12596378 4865:15959466 4836:16354918 4793:16984997 4732:17108970 4695:17531325 4616:23205959 4575:41704867 4567:28528665 4490:18834560 4408:34444905 4357:24907247 4349:18091016 4308:10221989 4270:12761368 4235:11583788 4200:16377242 4165:12223787 4116:43003476 4108:17395389 4065:11390928 4019:17499106 3978:84891972 3970:12467378 3834:24188696 3826:17969168 3804:Dev. Dyn 3752:17589520 3732:Nat. Med 3716:29627388 3667:21604972 3618:15470076 3577:22927941 3537:PLOS ONE 3510:10227421 3468:26724496 3433:86144218 3390:27916274 3348:25008178 3326:Diabetes 3307:23995958 3277:Diabetes 3258:21709230 3141:19190758 3100:PLoS ONE 3080:18852839 3031:12163549 2988:12209121 2949:11264309 2900:30672030 2849:11371348 2759:10908617 2653:11715055 2618:16512345 2513:17928584 2478:18500393 2418:37495761 2375:40744562 2367:16410524 2269:30044221 2180:26500584 2154:: 1520. 1986:GABA tea 1959:See also 1953:apoplast 1843:saclofen 1832:phenibut 1824:propofol 1820:baclofen 1695:yangonin 1610:gabazine 1585:propofol 1565:zolpidem 1516:Muscimol 1481:proteins 1376:oxidized 1327:cofactor 1310:via the 1250:carboxyl 1155:diabetes 1148:glucagon 1137:pancreas 1097:receptor 1074:neurites 1027:neonatal 1013:chloride 910:Function 878:neuronal 757:Hazards 335:DrugBank 304:ChEMBL96 9564:Glycine 9453:EF-1502 9178:BHF-177 9163:Tolibut 9073:BL-1020 8986:ROD-188 8851:4-ACPAM 8846:3-APMPA 8713:BL-1020 8673:U-93631 8668:Thujone 8593:PWZ-029 8567:(i.e., 8526:(e.g., 8504:MRK-016 8484:Lindane 8436:(e.g., 8417:(e.g., 8407:(e.g., 8276:(e.g., 8254:β-EMGBL 8164:PHP-501 8100:(e.g., 8071:(e.g., 8049:ROD-188 8036:(e.g., 8026:(e.g., 8011:(e.g., 7996:(e.g., 7994:Phenols 7976:(e.g., 7968:(e.g., 7960:(e.g., 7952:(e.g., 7948:(e.g., 7920:(e.g., 7885:(e.g., 7861:(e.g., 7851:(e.g., 7831:(e.g., 7801:(e.g., 7789:Bromide 7781:(e.g., 7771:(e.g., 7761:(e.g., 7742:(e.g., 7735:α-EMTBL 7705:borneol 7703:(e.g., 7686:Taurine 7633:(e.g., 7603:(e.g., 7601:Lignans 7521:BL-1020 7508:(e.g., 7297:Vitamin 7191:RVD-Hpα 7146:AA-5-HT 6893:Taurine 6878:Proline 6868:Glycine 6811:Proline 6781:Glycine 6626:Cystine 6622:(5-ALA) 6528:(heart) 6384:Medical 6336:(toxic) 6195:4256671 6152:7058221 6099:2634229 6078:Bibcode 5994:Plant J 5909:4532832 5888:Bibcode 5828:8303292 5564:8693922 5489:Bibcode 5462:8987785 5453:6573228 5404:2665930 5285:4393717 5277:9311780 5257:Bibcode 5198:Bibcode 5062:2422758 5042:Bibcode 5034:Science 5013:2160838 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Index

Gamma-aminobutyric acid
Gaba (disambiguation)
Simplified structural formula
GABA molecule
/ˈɡæməəˈmnbjuːˈtɪrɪkˈæsɪd/
/ˈɡæbə/
Preferred IUPAC name
CAS Number
56-12-2
JSmol
Interactive image
Beilstein Reference
ChEBI
CHEBI:16865
ChEMBL
ChEMBL96
ChemSpider
116
DrugBank
DB02530
ECHA InfoCard
100.000.235
Edit this at Wikidata
EC Number
Gmelin Reference
IUPHAR/BPS
1067
KEGG
D00058
MeSH

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