20:
229:
Understand how empirical spectral distribution of G predicts the response to selection across phenotypic space. In particular, trait combinations that form a nearly null genetic subspace with little genetic variance respond only inconsistently to selection. They set out a framework for understanding
102:
refers to how much of the phenotypic variance is due to variance in genetic factors. Usually after we know the total amount of genetic variance that is responsible for a trait, we can calculate the trait heritability. Heritability can be used as an important predictor to evaluate if a population can
248:
The development of single-nucleotide polymorphisms (SNPs) mapping helps to explore the genetic variation of complex traits at individual loci. Researchers can quantify the contribution of additive, dominance, and imprinting variance to the total genetic variance by using a SNP regression method.
90:
Additive genetic variance involves the inheritance of a particular allele from your parent and this allele's independent effect on the specific phenotype, which will cause the phenotype deviation from the mean phenotype. Dominance genetic variance refers to the phenotype deviation caused by the
239:
In this research, the researchers use the different relationship models to compare estimates of genetic variance components and the heritability. However, different models may give different estimates of genetic variances. They found that expected genetic variances usually equals the estimated
230:
how the empirical spectral distribution of G may differ from the random expectations that have been developed under random matrix theory (RMT). Using a data set containing a large number of gene expression traits.
86:
Phenotypic variance, usually combines the genotype variance with the environmental variance. Genetic variance has three major components: the additive genetic variance, dominance variance, and epistatic variance.
215:
3. Genetic variance–covariance (G) matrices conveniently summarize the genetic relationships among a suite of traits and are a central parameter in the determination of the multivariate response to selection.
240:
variance times a statistic, Dk, and for the most typical models of relationships, Dk is close to 1, which means most of these models can be used to estimate the genetic variance.
91:
interactions between alternative alleles that control one trait at one specific locus. Epistatic variance involves an interaction between different alleles in different loci.
45:
114:, Involves the proportion of phenotypic variation due to the effects of additive, dominance, and epistatic variance. Narrow-sense heritability, h = V
58:
can be calculated by the genetic variance of the fitness itself. Fisher tried to give a statistical formula about how the change of fitness in a
50:
395:
Blows, M. W.; McGuigan, K. (2015). "The distribution of genetic variance across phenotypic space and the response to selection".
212:) regression method to quantify the contribution of additive, dominance, and imprinting variance to the total genetic variance.
265:
Crow, JF (2002). "Perspective: Here's to Fisher, additive genetic variance, and the fundamental theorem of natural selection".
488:
BLOWS, MW; MCGUIGAN, K. The distribution of genetic variance across phenotypic space and the response to selection.
555:
Lopes, Marcos S., et al. "Estimation of
Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data."
446:
Lande, R (1979). "Quantitative genetic-analysis of multivariate evolution, applied to brain-body size allometry".
385:
Lynch, M., & Walsh, B. Genetics and
Analysis of Quantitative Traits (Sunderland, MA, Sinauer Associates, 1998)
318:
MONNAHAN, PJ; KELLY, JK. Epistasis Is a Major
Determinant of the Additive Genetic Variance in Mimulus guttatus.
278:
596:
209:
163:
The total amount of genetic variance can be divided into several groups, including additive variance (V
601:
376:
Falconer, D. S., & Mackay, T. C. F. Introduction to
Quantitative Genetics (London, Longman, 1996)
581:
497:
327:
225:
1. The distribution of genetic variance across phenotypic space and the response to selection.
122:, refers to the proportion of phenotypic variation that is due to additive genetic values (V
522:
404:
8:
526:
408:
244:
3. Estimation of
Additive, Dominance, and Imprinting Genetic Variance Using Genomic Data
463:
428:
307:
290:
66:. Fisher made no restrictive assumptions in his formula concerning fitness parameters,
538:
493:
471:
420:
323:
294:
282:
205:
data in humans, plants, and livestock species to estimate additive genetic variance.
55:
530:
455:
432:
412:
274:
75:
63:
359:
Hill, W. G., et al. Data and theory point to mainly additive genetic variance for
360:
234:
2. Comparing estimates of genetic variance across different relationship models
202:
576:
571:
534:
511:"Comparing estimates of genetic variance across different relationship models"
590:
341:
Byers, D. (2008) Components of phenotypic variance. Nature
Education 1(1):161
41:
308:
Fisher's
Fundamental Theorem of Natural Selection Revisited by Sabin Lessard
542:
475:
424:
286:
99:
350:
Byers, D. (2008) Components of phenotypic variance. Nature
Education 1(1)
67:
467:
59:
38:
416:
34:
19:
510:
459:
31:
71:
577:
Introduction to genetic variance components and heritability
279:
10.1554/0014-3820(2002)056[1313:phstfa]2.0.co;2
138:) in a population is influenced by genetic variance (V
588:
54:, Fisher postulates that the rate of change of
582:Introduction to quantitative genetic variance
394:
208:2. Using a single-nucleotide polymorphisms (
103:respond to artificial or natural selection.
572:Quantitative genetic variance Youtube video
337:
335:
51:The Genetical Theory of Natural Selection
46:fundamental theorem of natural selection
18:
508:
332:
589:
445:
129:
264:
219:
62:can be attributed to changes in the
196:
13:
14:
613:
565:
549:
502:
482:
439:
106:Broad-sense heritability, H = V
94:
515:Theoretical Population Biology
388:
379:
370:
353:
344:
312:
301:
258:
142:) and environmental sources (V
1:
252:
81:
30:is a concept outlined by the
557:G3: Genes| Genomes| Genetics
171:), and epistatic variance (V
7:
10:
618:
134:The phenotypic variance (V
535:10.1016/j.tpb.2015.08.005
322:. 11, 5, 1-21, May 2015.
509:Legarra, Andres (2016).
201:1. Traditionally, using
167:), dominance variance (V
559:5.12 (2015): 2629-2637.
24:
597:Quantitative genetics
23:Ronald Fisher in 1913
22:
527:2016TPBio.107...26L
409:2015MolEc..24.2056B
48:. In his 1930 book
130:Quantitive formula
56:biological fitness
25:
16:Biological concept
492:. 9, 2056, 2015.
490:Molecular Ecology
417:10.1111/mec.13023
397:Molecular Ecology
367:, e1000008 (2008)
220:Research examples
70:or the number of
609:
602:Sexual selection
560:
553:
547:
546:
506:
500:
486:
480:
479:
443:
437:
436:
403:(9): 2056–2072.
392:
386:
383:
377:
374:
368:
363:. PLoS Genetics
357:
351:
348:
342:
339:
330:
316:
310:
305:
299:
298:
262:
197:Measuring method
64:allele frequency
28:Genetic variance
617:
616:
612:
611:
610:
608:
607:
606:
587:
586:
568:
563:
554:
550:
507:
503:
487:
483:
460:10.2307/2407630
444:
440:
393:
389:
384:
380:
375:
371:
358:
354:
349:
345:
340:
333:
317:
313:
306:
302:
263:
259:
255:
222:
199:
193:
189:
185:
181:
174:
170:
166:
160:
156:
152:
145:
141:
137:
132:
125:
121:
117:
113:
109:
97:
84:
17:
12:
11:
5:
615:
605:
604:
599:
585:
584:
579:
574:
567:
566:External links
564:
562:
561:
548:
501:
481:
454:(1): 402–416.
438:
387:
378:
369:
361:complex traits
352:
343:
331:
311:
300:
256:
254:
251:
221:
218:
198:
195:
191:
187:
183:
179:
172:
168:
164:
158:
154:
150:
143:
139:
135:
131:
128:
123:
119:
115:
111:
107:
96:
93:
83:
80:
15:
9:
6:
4:
3:
2:
614:
603:
600:
598:
595:
594:
592:
583:
580:
578:
575:
573:
570:
569:
558:
552:
544:
540:
536:
532:
528:
524:
520:
516:
512:
505:
499:
495:
491:
485:
477:
473:
469:
465:
461:
457:
453:
449:
442:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
391:
382:
373:
366:
362:
356:
347:
338:
336:
329:
325:
321:
320:PLoS Genetics
315:
309:
304:
296:
292:
288:
284:
280:
276:
273:(7): 1313–6.
272:
268:
261:
257:
250:
246:
245:
241:
237:
235:
231:
227:
226:
217:
213:
211:
206:
204:
194:
176:
161:
147:
127:
104:
101:
92:
88:
79:
77:
73:
69:
65:
61:
57:
53:
52:
47:
43:
42:Ronald Fisher
40:
36:
33:
29:
21:
556:
551:
518:
514:
504:
489:
484:
451:
447:
441:
400:
396:
390:
381:
372:
364:
355:
346:
319:
314:
303:
270:
266:
260:
247:
243:
242:
238:
233:
232:
228:
224:
223:
214:
207:
200:
177:
162:
148:
133:
105:
100:Heritability
98:
95:Heritability
89:
85:
68:mate choices
49:
39:statistician
27:
26:
591:Categories
253:References
82:Definition
78:involved.
60:population
521:: 26–30.
498:0962-1083
448:Evolution
328:1553-7390
295:198157405
267:Evolution
35:biologist
543:26341159
476:28568194
425:25438617
287:12206233
203:pedigree
523:Bibcode
468:2407630
433:2242258
405:Bibcode
72:alleles
44:in his
32:English
541:
496:
474:
466:
431:
423:
326:
293:
285:
464:JSTOR
429:S2CID
291:S2CID
539:PMID
494:ISSN
472:PMID
421:PMID
324:ISSN
283:PMID
76:loci
74:and
37:and
531:doi
519:107
456:doi
413:doi
275:doi
210:SNP
190:+ V
186:+ V
182:= V
175:).
157:+ V
153:= V
126:).
593::
537:.
529:.
517:.
513:.
470:.
462:.
452:33
450:.
427:.
419:.
411:.
401:24
399:.
334:^
289:.
281:.
271:56
269:.
236:.
146:)
118:/V
110:/V
545:.
533::
525::
478:.
458::
435:.
415::
407::
365:4
297:.
277::
192:I
188:D
184:A
180:G
178:V
173:I
169:D
165:A
159:E
155:G
151:P
149:V
144:E
140:G
136:P
124:A
120:P
116:A
112:P
108:G
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
